Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

ARID1A CHD6

4.46e-0437172GO:0140658
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

FOXA2 HOXD10 IRF4 STAT6

1.09e-03560174GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

FOXA2 HOXD10 IRF4 STAT6

1.13e-03566174GO:0001216
GeneOntologyMolecularFunctiontranscription coactivator activity

ARID1A IRF4 SS18L1

2.01e-03303173GO:0003713
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

ARID1A IRF4 IRS1 SS18L1 ATG2B

2.26e-031160175GO:0030674
GeneOntologyMolecularFunctionchromatin binding

ARID1A FOXA2 HOXD10 CHD6

3.01e-03739174GO:0003682
GeneOntologyMolecularFunctiontranscription factor binding

ARID1A FOXA2 CHD6 STAT6

3.22e-03753174GO:0008134
GeneOntologyMolecularFunctionmolecular adaptor activity

ARID1A IRF4 IRS1 SS18L1 ATG2B

4.45e-031356175GO:0060090
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

ARID1A CHD6

5.13e-03127172GO:0008094
GeneOntologyMolecularFunctiontranscription coregulator binding

CHD6 STAT6

6.20e-03140172GO:0001221
GeneOntologyBiologicalProcesscell fate commitment

FOXA2 HOXD10 IRF4 STAT6

8.38e-05338154GO:0045165
GeneOntologyBiologicalProcesscellular response to reactive nitrogen species

CCNA2 STAT6

9.31e-0520152GO:1902170
GeneOntologyBiologicalProcessT-helper cell lineage commitment

IRF4 STAT6

1.71e-0427152GO:0002295
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell lineage commitment

IRF4 STAT6

2.27e-0431152GO:0043373
GeneOntologyBiologicalProcessalpha-beta T cell lineage commitment

IRF4 STAT6

2.57e-0433152GO:0002363
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

FOXA2 HOXD10 IRF4 CHD6 SS18L1 STAT6

2.73e-041390156GO:0045944
GeneOntologyBiologicalProcessCD4-positive or CD8-positive, alpha-beta T cell lineage commitment

IRF4 STAT6

2.90e-0435152GO:0043369
GeneOntologyBiologicalProcesschromatin organization

ARID1A FOXA2 IRF4 CHD6 SS18L1

3.19e-04896155GO:0006325
GeneOntologyBiologicalProcessneuron fate specification

FOXA2 HOXD10

4.18e-0442152GO:0048665
GeneOntologyBiologicalProcessT cell lineage commitment

IRF4 STAT6

4.18e-0442152GO:0002360
GeneOntologyBiologicalProcessprotein-DNA complex organization

ARID1A FOXA2 IRF4 CHD6 SS18L1

5.27e-04999155GO:0071824
GeneOntologyBiologicalProcesscell-cell adhesion mediated by cadherin

FOXA2 PLEKHA7

5.93e-0450152GO:0044331
GeneOntologyBiologicalProcesspositive T cell selection

IRF4 STAT6

6.66e-0453152GO:0043368
GeneOntologyCellularComponentchromatin

ARID1A FOXA2 HOXD10 IRF4 CHD6 SS18L1 STAT6

1.94e-051480147GO:0000785
GeneOntologyCellularComponentnBAF complex

ARID1A SS18L1

4.97e-0516142GO:0071565
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

ARID1A SS18L1

1.83e-0396142GO:0070603
GeneOntologyCellularComponentATPase complex

ARID1A SS18L1

3.28e-03129142GO:1904949
GeneOntologyCellularComponentprotein kinase complex

IRS1 CCNA2

5.61e-03170142GO:1902911
GeneOntologyCellularComponenttranscription regulator complex

FOXA2 HOXD10 STAT6

6.64e-03596143GO:0005667
Domain-

FOXA2 IRF4

1.64e-022181721.10.10.10
DomainPH

PLEKHA7 IRS1

1.80e-02229172PF00169
DomainWHTH_DNA-bd_dom

FOXA2 IRF4

2.00e-02242172IPR011991
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_PIGMENTATION

ARID1A IRF4 SS18L1

6.89e-0642133M48237
PathwayPID_IL4_2PATHWAY

IRF4 IRS1 STAT6

2.47e-0564133M28
PathwayBIOCARTA_IL4_PATHWAY

IRS1 STAT6

4.30e-0511132MM1413
PathwayBIOCARTA_IL4_PATHWAY

IRS1 STAT6

4.30e-0511132M5415
PathwayREACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION

ARID1A IRF4 SS18L1

8.07e-0595133M48268
PathwayWP_FOXA2_PATHWAY

FOXA2 IRS1

1.63e-0421132M42579
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

ARID1A IRF4 SS18L1

2.39e-04137133M48232
PathwaySIG_IL4RECEPTOR_IN_B_LYPHOCYTES

IRS1 STAT6

2.72e-0427132M1718
PathwayWP_IL7_SIGNALING_PATHWAY

IRS1 CCNA2

6.94e-0443132MM15864
PathwayWP_ID_SIGNALING_PATHWAY

IRS1 CCNA2

9.38e-0450132MM15817
PathwayWP_IL4_SIGNALING

IRS1 STAT6

1.09e-0354132M39720
PathwayWP_TH17_CELL_DIFFERENTIATION_PATHWAY

IRF4 STAT6

1.78e-0369132M45541
Pubmed

Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation.

IRF4 STAT6

2.25e-07217223254356
Pubmed

IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.

IRF4 STAT6

6.74e-07317227653687
Pubmed

Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins.

FOXA2 STAT6

6.74e-07317225287927
Pubmed

Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.

IRF4 STAT6

6.74e-07317210601358
Pubmed

Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins.

IRF4 STAT6

1.35e-06417211342629
Pubmed

Transcriptional regulation of macrophage polarization: enabling diversity with identity.

IRF4 STAT6

2.25e-06517222025054
Pubmed

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.

IRF4 STAT6

2.25e-06517227760338
Pubmed

Th9 cell development requires a BATF-regulated transcriptional network.

IRF4 STAT6

2.25e-06517224216482
Pubmed

IL-4/IL-13 signaling beyond JAK/STAT.

IRS1 STAT6

4.72e-06717210856136
Pubmed

Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization.

IRF4 STAT6

8.08e-06917234795444
Pubmed

Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo.

FOXA2 CCNA2

1.23e-051117218224709
Pubmed

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

FOXA2 STAT6

1.48e-051217219369400
Pubmed

Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

ARID1A SS18L1

2.35e-051517223785148
Pubmed

Geminin is required for Hox gene regulation to pattern the developing limb.

FOXA2 HOXD10

3.05e-051717232450229
Pubmed

Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity.

FOXA2 HOXD10

3.83e-051917227453501
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

ARID1A CHD6 SS18L1

5.86e-0515717330186101
Pubmed

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

ARID1A SS18L1

9.06e-052917219279220
Pubmed

CRL4AMBRA1 is a master regulator of D-type cyclins.

IRS1 CCNA2

9.70e-053017233854235
Pubmed

Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.

FOXA2 HOXD10

1.18e-043317218662545
Pubmed

A protein interaction landscape of breast cancer.

ARID1A PLEKHA7 IRS1 CCNA2

2.16e-0463417434591612
Pubmed

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

FOXA2 IRS1

3.29e-045517222581228
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

ARID1A SS18L1

4.59e-046517226655900
Pubmed

Human transcription factor protein interaction networks.

ARID1A IRF4 CHD6 SS18L1 CCNA2

4.76e-04142917535140242
InteractionIRF4 interactions

ARID1A IRF4 STAT6

4.72e-0585173int:IRF4
InteractionSS18 interactions

ARID1A IRF4 SS18L1

5.23e-0588173int:SS18
InteractionEN2 interactions

FOXA2 HOXD10

6.06e-0514172int:EN2
InteractionDPF1 interactions

ARID1A IRF4 SS18L1

6.58e-0595173int:DPF1
InteractionCREBBP interactions

ARID1A HOXD10 SS18L1 CCNA2 STAT6

1.05e-04599175int:CREBBP
InteractionETS1 interactions

ARID1A SS18L1 STAT6

1.35e-04121173int:ETS1
InteractionBCL7A interactions

ARID1A IRF4 SS18L1

1.42e-04123173int:BCL7A
InteractionPAX7 interactions

ARID1A CHD6 SS18L1

1.45e-04124173int:PAX7
InteractionHOXB13 interactions

FOXA2 IRF4

1.99e-0425172int:HOXB13
InteractionNCOA1 interactions

ARID1A FOXA2 STAT6

2.35e-04146173int:NCOA1
InteractionARID2 interactions

ARID1A IRF4 SS18L1

2.70e-04153173int:ARID2
InteractionARID1B interactions

ARID1A IRF4 SS18L1

4.14e-04177173int:ARID1B
InteractionGATA2 interactions

ARID1A CHD6 CCNA2

5.82e-04199173int:GATA2
InteractionFEV interactions

ARID1A CHD6 SS18L1

6.17e-04203173int:FEV
InteractionEP300 interactions

ARID1A HOXD10 IRF4 SS18L1 CCNA2 STAT6

7.09e-041401176int:EP300
CytobandEnsembl 112 genes in cytogenetic band chr14q32

SERPINA10 ATG2B

1.83e-02566172chr14q32
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHA7 IRS1

1.07e-02206142682
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-5|TCGA-Stomach / Sample_Type by Project: Shred V9

HOXD10 SERPINA10 SS18L1

2.84e-05159173c40fe552da3abdb1df87e9e1647468dc038bec0a
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HOXD10 IRF4 RNF44

3.23e-051661733b67064a5149e72f895344d938c64b8ff65247f5
ToppCellmild_COVID-19_(asymptomatic)-Plasmablast|World / disease group, cell group and cell class (v2)

IRF4 IRS1 CCNA2

3.29e-05167173f26ae4de4804a3486502e3df37eabf3dfca688f5
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell|E16.5-samps / Age Group, Lineage, Cell class and subclass

FOXA2 PLEKHA7 SERPINA10

3.47e-051701735a64e05c263df915085988d881808221e2c0f2e2
Drug6-mercaptopurine monohydrate; Down 200; 10uM; PC3; HG-U133A

FOXA2 IRS1 SS18L1 CCNA2

8.76e-06195164667_DN
DiseaseSquamous cell carcinoma of the head and neck

HOXD10 IRS1 CCNA2

2.84e-0652163C1168401
DiseaseGranulomatous Slack Skin

ARID1A IRF4

6.33e-0522162C0376407
DiseaseLymphoma, T-Cell, Cutaneous

ARID1A IRF4

6.93e-0523162C0079773
Diseasegastric adenocarcinoma (is_marker_for)

ARID1A STAT6

1.03e-0428162DOID:3717 (is_marker_for)
DiseaseHyperinsulinism

FOXA2 IRS1

1.03e-0428162C0020459
DiseaseCarcinoma, Transitional Cell

ARID1A CHD6

2.23e-0441162C0007138
DiseaseNeuroblastoma

ARID1A CHD6

2.94e-0447162C0027819
Diseaseasthma, age at onset

IRF4 STAT6

6.52e-0470162EFO_0004847, MONDO_0004979
Diseaseage of onset of childhood onset asthma

IRF4 STAT6

1.12e-0392162OBA_2001015
Diseasecreatinine measurement

ARID1A HOXD10 PLEKHA7 CCNA2

1.69e-03995164EFO_0004518
Diseasesporadic amyotrophic lateral sclerosis

ARID1A HOXD10

2.57e-03140162EFO_0001357
DiseaseBladder Neoplasm

ARID1A CHD6

2.57e-03140162C0005695
DiseaseMalignant neoplasm of urinary bladder

ARID1A CHD6

2.60e-03141162C0005684
Diseaselung non-small cell carcinoma (is_marker_for)

ARID1A FOXA2

3.71e-03169162DOID:3908 (is_marker_for)
Diseasetype 2 diabetes mellitus (is_implicated_in)

FOXA2 IRS1

3.80e-03171162DOID:9352 (is_implicated_in)
DiseaseProstatic Neoplasms

ARID1A IRS1 CHD6

4.14e-03616163C0033578
DiseaseMalignant neoplasm of prostate

ARID1A IRS1 CHD6

4.14e-03616163C0376358
Diseasemosquito bite reaction size measurement

TAAR2 STAT6

5.77e-03212162EFO_0008378
Diseaseneutrophil percentage of granulocytes

IRF4 STAT6

6.64e-03228162EFO_0007994
Diseaseeosinophil percentage of granulocytes

IRF4 STAT6

6.98e-03234162EFO_0007996
Diseasebasophil count, eosinophil count

IRF4 STAT6

7.39e-03241162EFO_0004842, EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
GSEPMYWSSFMTSSM

ATG2B

111

Q96BY7
SMAGMINPQGPPYSM

ARID1A

936

O14497
MSMSHPYTMTTPYPS

IRF4

146

Q15306
GPQMSYGTMSYSTEM

BEND2

396

Q8NDZ0
GYMMMSPSGGCSPDI

IRS1

661

P35568
LIYPSMFLSPGMGMA

CHD6

2621

Q8TD26
SASMYMPPPSADMGT

HOXD10

31

P28358
MPPPSADMGTYGMQT

HOXD10

36

P28358
MLPYYTAQSSPAMGM

GARIN6

6

Q8NEG0
YPMDGSFESPHTMDM

CCNA2

146

P20248
GSMNMSSYVGAGMSP

FOXA2

61

Q9Y261
MGGLAPYANMNSMSP

FOXA2

121

Q9Y261
MGYNSDSPMGSMTPF

SAMD8

86

Q96LT4
SMPSMGYMTHTVSAP

PLEKHA7

631

Q6IQ23
SQGSSMMGQRPMAPY

SS18L1

221

O75177
MVPSYDLGMAPDSSM

STAT6

666

P42226
PYFLSMLPMSPTAMG

RNF44

306

Q7L0R7
TTLFMAGFFTPGSMM

TAAR2

211

Q9P1P5
GNMVFSPFGMSLAMT

SERPINA10

96

Q9UK55