Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of immature T cell proliferation in thymus	TMEM131L RIPK2	1.90e-04	17	25	2	GO:0033084
GeneOntologyBiologicalProcess	regulation of immature T cell proliferation	TMEM131L RIPK2	2.13e-04	18	25	2	GO:0033083
GeneOntologyBiologicalProcess	basic amino acid transmembrane transport	SLC7A4 SLC11A1	2.38e-04	19	25	2	GO:1990822
GeneOntologyBiologicalProcess	immature T cell proliferation in thymus	TMEM131L RIPK2	2.38e-04	19	25	2	GO:0033080
GeneOntologyBiologicalProcess	positive regulation of T-helper 1 type immune response	SLC11A1 RIPK2	2.64e-04	20	25	2	GO:0002827
GeneOntologyBiologicalProcess	immature T cell proliferation	TMEM131L RIPK2	2.64e-04	20	25	2	GO:0033079
GeneOntologyBiologicalProcess	basic amino acid transport	SLC7A4 SLC11A1	3.21e-04	22	25	2	GO:0015802
Domain	K_chnl_volt-dep_ERG	KCNH6 KCNH2	6.03e-06	3	27	2	IPR003967
Domain	Plakophilin/d_Catenin	CTNND2 PKP4	4.21e-05	7	27	2	IPR028435
Domain	PAS_9	KCNH6 KCNH2	8.99e-05	10	27	2	PF13426
Domain	K_chnl_volt-dep_EAG/ELK/ERG	KCNH6 KCNH2	1.81e-04	14	27	2	IPR003938
Domain	PAS-assoc_C	KCNH6 KCNH2	5.45e-04	24	27	2	IPR000700
Domain	PAS	KCNH6 KCNH2	5.92e-04	25	27	2	PF00989
Domain	PAS_fold	KCNH6 KCNH2	5.92e-04	25	27	2	IPR013767
Domain	PAC	KCNH6 KCNH2	6.40e-04	26	27	2	SM00086
Domain	PAC	KCNH6 KCNH2	6.40e-04	26	27	2	PS50113
Domain	PAC	KCNH6 KCNH2	6.40e-04	26	27	2	IPR001610
Domain	Arm	CTNND2 PKP4	9.12e-04	31	27	2	PF00514
Domain	CNMP_BINDING_1	KCNH6 KCNH2	9.72e-04	32	27	2	PS00888
Domain	CNMP_BINDING_2	KCNH6 KCNH2	9.72e-04	32	27	2	PS00889
Domain	cNMP	KCNH6 KCNH2	1.10e-03	34	27	2	SM00100
Domain	PAS	KCNH6 KCNH2	1.10e-03	34	27	2	IPR000014
Domain	PAS	KCNH6 KCNH2	1.10e-03	34	27	2	PS50112
Domain	cNMP_binding	KCNH6 KCNH2	1.10e-03	34	27	2	PF00027
Domain	cNMP-bd_dom	KCNH6 KCNH2	1.16e-03	35	27	2	IPR000595
Domain	CNMP_BINDING_3	KCNH6 KCNH2	1.16e-03	35	27	2	PS50042
Domain	cNMP-bd-like	KCNH6 KCNH2	1.37e-03	38	27	2	IPR018490
Domain	ARM	CTNND2 PKP4	1.52e-03	40	27	2	SM00185
Domain	ARM_REPEAT	CTNND2 PKP4	1.52e-03	40	27	2	PS50176
Domain	Armadillo	CTNND2 PKP4	2.09e-03	47	27	2	IPR000225
Domain	-	KCNH6 KCNH2	2.18e-03	48	27	2	2.60.120.10
Domain	RmlC-like_jellyroll	KCNH6 KCNH2	2.46e-03	51	27	2	IPR014710
Domain	-	BTAF1 CTNND2 PKP4	3.93e-03	222	27	3	1.25.10.10
Domain	ARM-like	BTAF1 CTNND2 PKP4	6.76e-03	270	27	3	IPR011989
Domain	Ion_trans_dom	KCNH6 KCNH2	1.17e-02	114	27	2	IPR005821
Domain	Ion_trans	KCNH6 KCNH2	1.17e-02	114	27	2	PF00520
Domain	ARM-type_fold	BTAF1 CTNND2 PKP4	1.26e-02	339	27	3	IPR016024
Pubmed	Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family.	CTNND2 PKP4	5.80e-07	2	27	2	9342840
Pubmed	PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071.	CTNND2 PKP4	1.74e-06	3	27	2	10896674
Pubmed	HERG K(+) currents in human prolactin-secreting adenoma cells.	KCNH6 KCNH2	1.74e-06	3	27	2	12634931
Pubmed	Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.	KCNH6 KCNH2	1.74e-06	3	27	2	35818223
Pubmed	Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.	KCNH6 KCNH2	1.74e-06	3	27	2	14643686
Pubmed	PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.	CTNND2 PKP4	3.48e-06	4	27	2	19706687
Pubmed	Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.	CTNND2 PKP4	5.80e-06	5	27	2	9721216
Pubmed	Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.	CTNND2 PKP4	5.80e-06	5	27	2	10037471
Pubmed	DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.	CTNND2 PKP4	1.22e-05	7	27	2	25009281
Pubmed	The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.	CTNND2 PKP4	1.62e-05	8	27	2	11821434
Pubmed	Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.	KCNH6 KCNH2	2.60e-05	10	27	2	26503718
Pubmed	Complex transcription and splicing of odorant receptor genes.	OR2H1 OR2H2	3.18e-05	11	27	2	12637542
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR2H1 OR2H2	4.50e-05	13	27	2	14506126
Pubmed	p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.	CTNND2 PKP4	1.45e-04	23	27	2	25523391
Pubmed	Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.	KCNH6 KCNH2	1.86e-04	26	27	2	31138815
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	CTNND2 PKP4	2.01e-04	27	27	2	24550280
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	USP22 DDB2	3.02e-04	33	27	2	11564863
Pubmed	Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.	PKP4 FRZB	3.60e-04	36	27	2	15745951
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCNH6 KCNH2	4.45e-04	40	27	2	16382104
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	BTAF1 USP22 PKP4	4.88e-04	199	27	3	31146259
Pubmed	Proteome-wide analysis of phospho-regulated PDZ domain interactions.	CTNND2 PKP4	4.90e-04	42	27	2	30126976
Pubmed	DNA sequence and analysis of human chromosome 8.	CHRNA2 RIPK2	6.40e-04	48	27	2	16421571
Cytoband	2q35	SLC11A1 CFAP65	9.98e-04	79	27	2	2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	SLC11A1 CFAP65	2.63e-03	129	27	2	chr2q35
GeneFamily	Potassium voltage-gated channels	KCNH6 KCNH2	7.14e-04	40	18	2	274
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CTNND2 PKP4	8.25e-04	43	18	2	409
GeneFamily	Olfactory receptors, family 2	OR2H1 OR2H2	5.55e-03	113	18	2	149
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KCNH6 SLC7A4 CTNND2 SYT10	4.41e-06	184	27	4	9e5f98f9113e5e38bdadba6d9d2c346177fb35fe
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNH6 INHBE SLC7A4 CFAP65	4.51e-06	185	27	4	2088e82e0febdcf05618d3db913d00e2e87812f4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM131L TGFBR3 SYT10 FRZB	4.51e-06	185	27	4	e87e6e097dc29ece8aea671935bde281b99b93ea
ToppCell	11.5-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	KCNH6 SLC7A4 KCNH2 CFAP65	5.12e-06	191	27	4	c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 CTNND2 SYT10 KCNH2	5.33e-06	193	27	4	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KCNH6 SLC7A4 CTNND2 CFAP65	5.33e-06	193	27	4	8603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CTNND2 SYT10 KCNH2 FRZB	5.78e-06	197	27	4	3a0e97bfebe82f9687d518baaad7f20d0ffea8a1
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	KCNH6 SYT10 CFAP65	3.47e-05	105	27	3	339e53aaa2b5255f248e0993268f6acd63762084
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	INHBE SLC11A1 FSCN3	9.06e-05	145	27	3	2eebf2294c53f081d3b0169071388e477a195218
ToppCell	PCW_13-14-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CTNND2 COL20A1 SYT10	1.13e-04	156	27	3	8353f98e7d393d4299ed1da8f66cfbc7176df1b5
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNH6 FSCN3 CFAP65	1.33e-04	165	27	3	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNH6 CHRNA2 CFAP65	1.40e-04	168	27	3	0f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TMEM131L TMEM94 ICE2	1.48e-04	171	27	3	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM131L SYT10 CHRNA2	1.48e-04	171	27	3	f6047dee2be0b09ad4d48f97369111bc92e89b35
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNH6 CHRNA2 CFAP65	1.48e-04	171	27	3	fa5cc720bd0045d0307439be547b41d56def5b43
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC7A4 SYT10 FRZB	1.58e-04	175	27	3	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 SYT10 KCNH2	1.63e-04	177	27	3	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-2_PVALB_TAC1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TGFBR3 SYT10 FRZB	1.66e-04	178	27	3	1985271984e6747941c8d2097d9c58f0260f021a
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|343B / Donor, Lineage, Cell class and subclass (all cells)	DENND6B TMEM131L TMEM94	1.66e-04	178	27	3	ec6364432d37a32f5152d36d89f5e96dddb72a9d
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	KCNH6 CTNND2 KCNH2	1.77e-04	182	27	3	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 SYT10 KCNH2	1.80e-04	183	27	3	6b5eef96b28911c752a8b6c0975918c4572cec38
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 SYT10 KCNH2	1.80e-04	183	27	3	af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 SYT10 KCNH2	1.83e-04	184	27	3	5cfc19ffb9f074bdf0d81c86e212a708ec141631
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNH6 CTNND2 SYT10	1.86e-04	185	27	3	a34663974868e267495240c0d5c06e390f57b08b
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNH6 CTNND2 SYT10	1.86e-04	185	27	3	b52e6adfecac93210c27c1d321a5951d54846c40
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNH6 CTNND2 SYT10	1.86e-04	185	27	3	522030941687a268ec2520248df1817b57744a19
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TGFBR3 SYT10 KCNH2	1.89e-04	186	27	3	cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CTNND2 COL20A1 SYT10	1.89e-04	186	27	3	cf96f880e6e22189593ce1357c55e65c34644559
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNH6 CTNND2 KCNH2	1.89e-04	186	27	3	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	15-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	KCNH6 KCNH2 CFAP65	1.92e-04	187	27	3	a7d2f30fe0f19e63d44603ece9890acd11b45e52
ToppCell	droplet-Lung-LUNG-1m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A4 SYT10 CFAP65	1.92e-04	187	27	3	6288da8cdd450c58df00ebcfcc118f01fab7e610
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNH6 CTNND2 KCNH2	1.95e-04	188	27	3	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KCNH6 CTNND2 CFAP65	2.01e-04	190	27	3	2375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KCNH6 SLC7A4 CFAP65	2.01e-04	190	27	3	5f1863bce9400b7c932f0e4d0e012ec4e8d7e555
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KCNH6 SLC7A4 CFAP65	2.04e-04	191	27	3	19832ddd559a353e1618fe853d79e3edfec6dcda
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KCNH6 SLC7A4 CFAP65	2.08e-04	192	27	3	4d3a1c267739b1479217144656986972fc86db43
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KCNH6 CTNND2 CFAP65	2.11e-04	193	27	3	aa10924b203c71e65fdbd2b90ba131dbd362d8b1
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CTNND2 KIAA0825 PKP4	2.11e-04	193	27	3	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CTNND2 KIAA0825 PKP4	2.11e-04	193	27	3	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CTNND2 KIAA0825 PKP4	2.14e-04	194	27	3	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH6 CTNND2 CFAP65	2.14e-04	194	27	3	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 SYT10 KCNH2	2.17e-04	195	27	3	eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFBR3 SYT10 KCNH2	2.17e-04	195	27	3	44f67437ea65d530133a0240b17f9860d9cc0e99
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KCNH6 SLC7A4 CFAP65	2.17e-04	195	27	3	5f33ece997f074598b4201ff74f592ee07c86a06
ToppCell	11.5-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	KCNH6 SLC7A4 CFAP65	2.17e-04	195	27	3	eda6ebe52c48bd6a9044886e75f584f46c2556e7
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTNND2 COL20A1 SYT10	2.24e-04	197	27	3	bb35a2b7320fda92e9cd42f536b7bd54e3a73a32
ToppCell	proximal-Epithelial-Neuroendocrine\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNH6 SYT10 CHRNA2	2.27e-04	198	27	3	5dea6078488d584513c0bdbf5bba54877310b54a
ToppCell	proximal-Epithelial-Neuroendocrine-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNH6 SYT10 CHRNA2	2.27e-04	198	27	3	00ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCell	proximal-3-Epithelial-Neuroendocrine\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNH6 SYT10 CHRNA2	2.27e-04	198	27	3	a6bc043faf68468d46bac441cf7447c236c7bae4
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.31e-04	199	27	3	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTNND2 COL20A1 SYT10	2.31e-04	199	27	3	1761669ec514fdb4175042f11b9a31fa5687fc2b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC7A4 SYT10 CHRNA2	2.34e-04	200	27	3	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	USP22 KIAA0825 PKP4	2.34e-04	200	27	3	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC7A4 SYT10 CHRNA2	2.34e-04	200	27	3	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC7A4 SYT10 CHRNA2	2.34e-04	200	27	3	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFBR3 SYT10 KCNH2	2.34e-04	200	27	3	87827041663013f5e7273168dc8709d69840e7ce
Drug	N-(1-(2,3-dimethoxyphenyl)-4-methyl-3-penten-1-yl)-1-(5-bromofurfuryl)-1-piperidyl-4-amine	KCNH6 KCNH2	1.35e-06	2	27	2	ctd:C531033
Drug	NS1643	KCNH6 KCNH2	8.11e-06	4	27	2	CID010177784
Drug	Doxazosin	KCNH6 KCNH2	2.03e-05	6	27	2	DB00590
Drug	Prazosin	KCNH6 KCNH2	2.03e-05	6	27	2	DB00457
Drug	Terazosin	KCNH6 KCNH2	2.03e-05	6	27	2	DB01162
Drug	Miconazole	KCNH6 KCNH2	3.78e-05	8	27	2	DB01110
Drug	miocamycin	INHBE CTNND2 PKP4	4.63e-05	59	27	3	CID005282188
Drug	Ibutilide	KCNH6 KCNH2	6.06e-05	10	27	2	DB00308
Drug	WAY-123,398	KCNH6 KCNH2	6.06e-05	10	27	2	CID000132160
Drug	carbanilide	KCNH6 KCNH2	7.40e-05	11	27	2	CID000007595
Drug	Graveoline [485-61-0]; Up 200; 14.4uM; PC3; HT_HG-U133A	CTNND2 CHRNA2 FSCN3 PKP4	7.54e-05	193	27	4	4276_UP
Drug	Yohimbinic acid monohydrate [27801-27-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	KCNH2 FSCN3 PKP4 FRZB	7.69e-05	194	27	4	4082_UP
Drug	Nomifensine maleate [32795-47-4]; Up 200; 11.2uM; PC3; HT_HG-U133A	KCNH6 CTNND2 FSCN3 RIPK2	8.00e-05	196	27	4	5863_UP
Drug	Tinidazole [19387-91-8]; Up 200; 16.2uM; PC3; HT_HG-U133A	KCNH6 CTNND2 CHRNA2 FSCN3	8.00e-05	196	27	4	4548_UP
Drug	Beclomethasone dipropionate [5534-09-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A	INHBE SLC11A1 KCNH2 FSCN3	8.16e-05	197	27	4	4403_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; PC3; HT_HG-U133A	INHBE SLC11A1 PKP4 FRZB	8.16e-05	197	27	4	4285_UP
Drug	PNU-0230031 [267429-39-0]; Up 200; 1uM; MCF7; HT_HG-U133A	TGFBR3 SLC11A1 KCNH2 CHRNA2	8.16e-05	197	27	4	4757_UP
Drug	Cephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A	SLC11A1 KCNH2 CHRNA2 FRZB	8.32e-05	198	27	4	5615_UP
Drug	malonate	KCNH6 SLC11A1 KCNH2 CHRNA2	1.03e-04	209	27	4	CID000000867
Drug	thioridazine	KCNH6 INHBE KCNH2	1.11e-04	79	27	3	CID000005452
Drug	fluoxetine	KCNH6 INHBE KCNH2 CHRNA2	1.36e-04	225	27	4	CID000003386
Drug	Doxepin	INHBE KCNH2	1.61e-04	16	27	2	ctd:D004316
Drug	Zimeldine	INHBE KCNH2	1.82e-04	17	27	2	ctd:D015031
Drug	Sotalol	INHBE KCNH2	2.05e-04	18	27	2	ctd:D013015
Drug	MK-499	KCNH6 KCNH2	2.29e-04	19	27	2	CID000127718
Drug	Hdba	KCNH6 KCNH2	2.29e-04	19	27	2	CID000003896
Drug	ether-a	KCNH6 KCNH2	3.08e-04	22	27	2	CID000501025
Drug	Clarithromycin	INHBE KCNH2	3.08e-04	22	27	2	ctd:D017291
Drug	Flecainide	INHBE KCNH2	4.32e-04	26	27	2	ctd:D005424
Drug	SB-505124	TGFBR3 INHBE	5.02e-04	28	27	2	CID009858940
Drug	Perhexiline	INHBE KCNH2	5.39e-04	29	27	2	ctd:D010480
Drug	Loratadine	INHBE KCNH2	5.77e-04	30	27	2	ctd:D017336
Drug	Pentamidine	INHBE KCNH2	6.99e-04	33	27	2	ctd:D010419
Drug	pentamidine	INHBE KCNH2	6.99e-04	33	27	2	CID000004735
Drug	XE991	KCNH6 KCNH2	6.99e-04	33	27	2	CID000656732
Drug	NSC15627	SLC11A1 KCNH2	7.42e-04	34	27	2	CID000002073
Drug	1,2-dichlorohexafluorocyclobutane	KCNH2 CHRNA2	8.79e-04	37	27	2	CID000009643
Drug	Thioridazine	INHBE KCNH2	8.79e-04	37	27	2	ctd:D013881
Drug	mM Q	KCNH6 KCNH2	1.08e-03	41	27	2	CID000445446
Drug	K-K-K	KCNH6 INHBE KCNH2	1.14e-03	175	27	3	CID000003823
Disease	short QT syndrome (implicated_via_orthology)	KCNH6 KCNH2	2.24e-06	3	26	2	DOID:0050793 (implicated_via_orthology)
Disease	long QT syndrome (implicated_via_orthology)	KCNH6 KCNH2	3.35e-05	10	26	2	DOID:2843 (implicated_via_orthology)
Disease	heart conduction disease (implicated_via_orthology)	KCNH6 KCNH2	3.64e-04	32	26	2	DOID:10273 (implicated_via_orthology)
Disease	Ulcerative Colitis	SLC11A1 RIPK2	1.41e-03	63	26	2	C0009324
Disease	Nonorganic psychosis	KCNH6 KCNH2	1.69e-03	69	26	2	C0349204
Disease	Psychotic Disorders	KCNH6 KCNH2	3.57e-03	101	26	2	C0033975
Disease	sleep duration, high density lipoprotein cholesterol measurement	DDB2 TMEM94	5.08e-03	121	26	2	EFO_0004612, EFO_0005271
Disease	Neoplastic Cell Transformation	CTNND2 KCNH2	6.65e-03	139	26	2	C0007621
Disease	Schizophrenia	KCNH6 CTNND2 KCNH2 CFAP65	7.05e-03	883	26	4	C0036341
Disease	autism spectrum disorder (implicated_via_orthology)	CTNND2 PKP4	7.90e-03	152	26	2	DOID:0060041 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	KCNH6 KCNH2	9.04e-03	163	26	2	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LWHPSVVKPYLTLLA	PKP4	821	Q99569
ARPGLWLYTHPLIKL	CASTOR1	16	Q8WTX7
HPLRLKLSPSYHWLE	CHRNA2	391	Q15822
STLHLPHWGYILLLL	SLC7A4	501	O43246
PFFIKTLQHWPHILR	DENND6B	336	Q8NEG7
LWHPSIVKPYLTLLS	CTNND2	841	Q9UQB3
QPLHYATIIHPRLCW	OR2H2	126	O95918
SLHYDLWTILPPKLA	KIAA0825	641	Q8IV33
TKPAILKPQHLTWYR	CFAP65	566	Q6ZU64
QAPRIHRWTILHYSP	KCNH2	391	Q12809
APRIHRWTILHYSPF	KCNH6	241	Q9H252
LYHARLWLHVLPTLP	INHBE	121	P58166
HLYYPKVPRTVLWLT	SLC11A1	126	P49279
HLTPIKAAWHPRYNL	DDB2	336	Q92466
WVPLDPSLLLPYHIH	ICE2	906	Q659A1
TVLVPRVWPFLHHTI	BTAF1	516	O14981
SWTPAPRHPLKYLIV	COL20A1	396	Q9P218
WTPRPALHVHVILYS	FSCN3	136	Q9NQT6
QPLHYATIIHPRLCW	OR2H1	126	Q9GZK4
LYPKPEALVHLLHRW	TMEM131L	626	A2VDJ0
RSPHIPYKLLHLVWT	USP22	236	Q9UPT9
HVHRTKPLWRKSPLT	TMEM94	1251	Q12767
PILIKYRHSWPENLA	FRZB	121	Q92765
LLHRKTEYPDVAWPL	RIPK2	106	O43353
AKHWMLHFPRITYPL	TMEM168	636	Q9H0V1
AYHRKPITHWHPLLE	SYT10	486	Q6XYQ8
SPHPLVWHLKTERLA	TGFBR3	106	Q03167