Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbohydrate binding	CLEC4F GUSB CLN5 GYS1 CLEC4G PKD1 LMAN2 PKD1L2 KLRG1	2.39e-06	310	75	9	GO:0030246
GeneOntologyMolecularFunction	monosaccharide binding	CLEC4F CLN5 GYS1 CLEC4G LMAN2	2.91e-05	95	75	5	GO:0048029
GeneOntologyMolecularFunction	D-mannose binding	CLN5 CLEC4G LMAN2	1.40e-04	27	75	3	GO:0005537
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	PRMT2 JMJD1C MED13	2.80e-04	34	75	3	GO:0046966
MousePheno	kidney medulla cyst	NPHS1 PKD1 ACE	2.27e-05	14	57	3	MP:0011307
Domain	-	CLEC4F CLEC4G PKD1 HAPLN4 PKD1L2 KLRG1	2.74e-06	97	76	6	3.10.100.10
Domain	C-type_lectin-like/link	CLEC4F CLEC4G PKD1 HAPLN4 PKD1L2 KLRG1	3.08e-06	99	76	6	IPR016186
Domain	CTDL_fold	CLEC4F CLEC4G PKD1 HAPLN4 PKD1L2 KLRG1	4.85e-06	107	76	6	IPR016187
Domain	NCK	NCK1 NCK2	1.63e-05	2	76	2	IPR017304
Domain	C_TYPE_LECTIN_1	CLEC4F CLEC4G PKD1 PKD1L2 KLRG1	1.85e-05	80	76	5	PS00615
Domain	Lectin_C	CLEC4F CLEC4G PKD1 PKD1L2 KLRG1	2.35e-05	84	76	5	PF00059
Domain	CLECT	CLEC4F CLEC4G PKD1 PKD1L2 KLRG1	2.35e-05	84	76	5	SM00034
Domain	C_TYPE_LECTIN_2	CLEC4F CLEC4G PKD1 PKD1L2 KLRG1	2.48e-05	85	76	5	PS50041
Domain	C-type_lectin-like	CLEC4F CLEC4G PKD1 PKD1L2 KLRG1	2.63e-05	86	76	5	IPR001304
Domain	SH3_1	PPP1R13B PRMT2 NCK1 ARHGEF4 PPP1R13L NCK2	5.50e-05	164	76	6	PF00018
Domain	REJ	PKD1 PKD1L2	9.75e-05	4	76	2	PS51111
Domain	ROC_dom	MFHAS1 LRRK1	9.75e-05	4	76	2	IPR020859
Domain	ROC	MFHAS1 LRRK1	9.75e-05	4	76	2	PS51424
Domain	REJ_dom	PKD1 PKD1L2	9.75e-05	4	76	2	IPR014010
Domain	PKD/REJ-like	PKD1 PKD1L2	2.43e-04	6	76	2	IPR002859
Domain	REJ	PKD1 PKD1L2	2.43e-04	6	76	2	PF02010
Domain	SH3	PPP1R13B PRMT2 NCK1 ARHGEF4 PPP1R13L NCK2	2.49e-04	216	76	6	SM00326
Domain	SH3	PPP1R13B PRMT2 NCK1 ARHGEF4 PPP1R13L NCK2	2.49e-04	216	76	6	PS50002
Domain	SH3_domain	PPP1R13B PRMT2 NCK1 ARHGEF4 PPP1R13L NCK2	2.74e-04	220	76	6	IPR001452
Domain	SH3_9	PRMT2 NCK1 PPP1R13L NCK2	2.87e-04	78	76	4	PF14604
Domain	PKD_channel	PKD1 PKD1L2	8.78e-04	11	76	2	PF08016
Domain	PKD1_2_channel	PKD1 PKD1L2	8.78e-04	11	76	2	IPR013122
Domain	Roc	MFHAS1 LRRK1	1.24e-03	13	76	2	PF08477
Domain	MIRO-like	MFHAS1 LRRK1	1.24e-03	13	76	2	IPR013684
Domain	SEA	MUC3B MUC3A	1.44e-03	14	76	2	SM00200
Domain	LH2	PKD1 PKD1L2	2.40e-03	18	76	2	SM00308
Domain	PLAT	PKD1 PKD1L2	3.26e-03	21	76	2	PS50095
Domain	-	PKD1 PKD1L2	3.26e-03	21	76	2	2.60.60.20
Domain	PLAT	PKD1 PKD1L2	3.26e-03	21	76	2	PF01477
Domain	PLAT/LH2_dom	PKD1 PKD1L2	3.26e-03	21	76	2	IPR001024
Domain	Quino_amine_DH_bsu	WDR6 LRRK1	3.58e-03	22	76	2	IPR011044
Domain	SEA	MUC3B MUC3A	3.91e-03	23	76	2	PS50024
Domain	SEA_dom	MUC3B MUC3A	3.91e-03	23	76	2	IPR000082
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	NPHS1 NCK1 NCK2	4.15e-06	9	53	3	MM14966
Pathway	REACTOME_DISEASES_OF_METABOLISM	POMT2 GUSB GYS1 NUS1 CFP MUC3A ALG12	3.90e-05	250	53	7	M27554
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	NPHS1 NCK1 NCK2	8.43e-05	23	53	3	M913
Pathway	REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN	DTX4 IRF3	1.38e-04	5	53	2	MM14942
Pathway	REACTOME_IRF3_MEDIATED_ACTIVATION_OF_TYPE_1_IFN	DTX4 IRF3	1.38e-04	5	53	2	M26979
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	POMT2 NUS1 CFP MUC3A ALG12	1.94e-04	143	53	5	M27275
Pathway	PID_NEPHRIN_NEPH1_PATHWAY	NPHS1 NCK1 NCK2	2.09e-04	31	53	3	M193
Pathway	REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES	DTX4 IRF3	2.88e-04	7	53	2	MM14706
Pathway	REACTOME_RHOV_GTPASE_CYCLE	WDR6 NCK1 NCK2	3.56e-04	37	53	3	M41819
Pathway	REACTOME_RHOV_GTPASE_CYCLE	WDR6 NCK1 NCK2	3.56e-04	37	53	3	MM15610
Pathway	REACTOME_RHOU_GTPASE_CYCLE	WDR6 NCK1 NCK2	4.17e-04	39	53	3	MM15607
Pathway	REACTOME_RHOU_GTPASE_CYCLE	WDR6 NCK1 NCK2	4.49e-04	40	53	3	M41816
Pathway	WP_GENES_CONTROLLING_NEPHROGENESIS	NPHS1 NCK1 NCK2	5.96e-04	44	53	3	M39891
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	DTX4 IRF3	1.05e-03	13	53	2	MM14931
Pathway	REACTOME_ACTIVATION_OF_RAC1	NCK1 NCK2	1.05e-03	13	53	2	M6322
Pathway	REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN	DTX4 IRF3	1.05e-03	13	53	2	M27240
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	PPP1R13B PPP1R13L	1.23e-03	14	53	2	M27638
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	PPP1R13B PPP1R13L	1.23e-03	14	53	2	MM15341
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	DTX4 IRF3	1.41e-03	15	53	2	M27229
Pathway	WP_ALANINE_AND_ASPARTATE_METABOLISM	ADSL CARNS1	1.41e-03	15	53	2	MM15960
Pathway	REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES	DTX4 IRF3	1.61e-03	16	53	2	M27045
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TO_ACTIN_SIGNALING_PATHWAY	NCK1 NCK2	1.82e-03	17	53	2	M47728
Pubmed	Nck proteins maintain the adult glomerular filtration barrier.	NPHS1 NCK1 NCK2	1.22e-08	3	81	3	19443634
Pubmed	Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.	NPHS1 NCK1 NCK2	4.86e-08	4	81	3	16525419
Pubmed	Fine tuning of the threshold of T cell selection by the Nck adapters.	NCK1 NCK2	5.36e-06	2	81	2	21078909
Pubmed	Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.	MUC3B MUC3A	5.36e-06	2	81	2	12958310
Pubmed	Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration.	NCK1 NCK2	5.36e-06	2	81	2	19242519
Pubmed	[A uNick protein].	NCK1 NCK2	5.36e-06	2	81	2	21880263
Pubmed	Nck adaptor proteins modulate differentiation and effector function of T cells.	NCK1 NCK2	5.36e-06	2	81	2	25995205
Pubmed	Nck adaptor proteins control the organization of neuronal circuits important for walking.	NCK1 NCK2	5.36e-06	2	81	2	18093944
Pubmed	Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.	NCK1 NCK2	5.36e-06	2	81	2	19596797
Pubmed	Nck influences preosteoblastic/osteoblastic migration and bone mass.	NCK1 NCK2	5.36e-06	2	81	2	26621720
Pubmed	Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.	MUC3B MUC3A	5.36e-06	2	81	2	10973822
Pubmed	MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region.	MUC3B MUC3A	5.36e-06	2	81	2	9334251
Pubmed	Molecular cloning of cDNAs derived from a novel human intestinal mucin gene.	MUC3B MUC3A	5.36e-06	2	81	2	2393399
Pubmed	Phase transitions of multivalent proteins can promote clustering of membrane receptors.	NPHS1 NCK1	5.36e-06	2	81	2	25321392
Pubmed	Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease.	MUC3B MUC3A	5.36e-06	2	81	2	11289722
Pubmed	Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.	NCK1 NCK2	5.36e-06	2	81	2	20709959
Pubmed	Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice.	NCK1 NCK2	5.36e-06	2	81	2	36035930
Pubmed	Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.	NPHS1 NCK1	5.36e-06	2	81	2	18212058
Pubmed	Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.	NCK1 NCK2	5.36e-06	2	81	2	37479911
Pubmed	The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.	NCK1 NCK2	5.36e-06	2	81	2	16636066
Pubmed	The MUC3 gene encodes a transmembrane mucin and is alternatively spliced.	MUC3B MUC3A	5.36e-06	2	81	2	10405327
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	WDR6 RRS1 GUSB NUS1 YLPM1 NCK1 PPP1R13L JMJD1C VARS1 NCK2	7.94e-06	733	81	10	34672954
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	PPP1R13B NCK1 ARHGEF4 NCK2	9.14e-06	56	81	4	22745667
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	CROCCP3 HAPLN4 PKD1L2 CCDC85A	1.46e-05	63	81	4	11572484
Pubmed	Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation.	NCK1 NCK2	1.60e-05	3	81	2	14676213
Pubmed	Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.	NPHS1 NCK1	1.60e-05	3	81	2	16543952
Pubmed	ASPP: a new family of oncogenes and tumour suppressor genes.	PPP1R13B PPP1R13L	1.60e-05	3	81	2	17211478
Pubmed	Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.	NCK1 NCK2	1.60e-05	3	81	2	33917227
Pubmed	ASPP--Apoptotic specific regulator of p53.	PPP1R13B PPP1R13L	1.60e-05	3	81	2	16139958
Pubmed	Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.	PPP1R13B PPP1R13L	1.60e-05	3	81	2	22552744
Pubmed	Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector.	NCK1 NCK2	1.60e-05	3	81	2	25482634
Pubmed	Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.	MUC3B MUC3A	1.60e-05	3	81	2	18163520
Pubmed	A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.	PPP1R13B PPP1R13L	1.60e-05	3	81	2	27177208
Pubmed	A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.	NCK1 NCK2	1.60e-05	3	81	2	29911835
Pubmed	Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.	NCK1 NCK2	1.60e-05	3	81	2	27033705
Pubmed	Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.	NCK1 NCK2	1.60e-05	3	81	2	16769879
Pubmed	Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin.	MUC3B MUC3A	1.60e-05	3	81	2	10512748
Pubmed	Selective role of Nck1 in atherogenic inflammation and plaque formation.	NCK1 NCK2	1.60e-05	3	81	2	32427580
Pubmed	Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.	NCK1 NCK2	1.60e-05	3	81	2	11240126
Pubmed	Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons.	NCK1 NCK2	1.60e-05	3	81	2	14517291
Pubmed	Nck-2 interacts with focal adhesion kinase and modulates cell motility.	NCK1 NCK2	1.60e-05	3	81	2	11950595
Pubmed	Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.	NCK1 NCK2	1.60e-05	3	81	2	31638742
Pubmed	Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells.	NCK1 NCK2	1.60e-05	3	81	2	17906149
Pubmed	The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.	NCK1 NCK2	1.60e-05	3	81	2	19371741
Pubmed	The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.	NCK1 NCK2	3.20e-05	4	81	2	1333047
Pubmed	NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.	DTX4 IRF3	3.20e-05	4	81	2	22388039
Pubmed	Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.	NCK1 NCK2	3.20e-05	4	81	2	18765673
Pubmed	Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.	NCK1 NCK2	3.20e-05	4	81	2	12110186
Pubmed	Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.	NCK1 NCK2	3.20e-05	4	81	2	17617578
Pubmed	Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.	NCK1 NCK2	3.20e-05	4	81	2	23913047
Pubmed	The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.	NCK1 NCK2	3.20e-05	4	81	2	12637565
Pubmed	NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.	NCK1 NCK2	3.20e-05	4	81	2	25913325
Pubmed	Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions.	NCK1 NCK2	3.20e-05	4	81	2	22074159
Pubmed	Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.	NCK1 NCK2	5.33e-05	5	81	2	9737977
Pubmed	The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.	NCK1 NCK2	5.33e-05	5	81	2	12808099
Pubmed	Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.	NCK1 NCK2	5.33e-05	5	81	2	12147689
Pubmed	The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.	PPP1R13B PPP1R13L	5.33e-05	5	81	2	21513714
Pubmed	Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.	NPHS1 NCK1	5.33e-05	5	81	2	17923684
Pubmed	Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models.	PPP1R13B PPP1R13L	5.33e-05	5	81	2	32828017
Pubmed	A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.	NCK1 NCK2	5.33e-05	5	81	2	35294890
Pubmed	Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.	NCK1 NCK2	5.33e-05	5	81	2	22454526
Pubmed	Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.	PKD1 NCK2	5.33e-05	5	81	2	20856870
Pubmed	Network organization of the human autophagy system.	ADSL HTRA2 TMEM160 GYS1 YLPM1 VARS1 TEDC1	7.36e-05	437	81	7	20562859
Pubmed	Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.	NCK1 NCK2	7.99e-05	6	81	2	24287595
Pubmed	Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.	NCK1 NCK2	7.99e-05	6	81	2	16835242
Pubmed	Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.	PPP1R13B PPP1R13L	7.99e-05	6	81	2	23088536
Pubmed	High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.	NCK1 NCK2	7.99e-05	6	81	2	1409582
Pubmed	Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.	NCK1 NCK2	7.99e-05	6	81	2	17803907
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1R13B PPP1R13L	7.99e-05	6	81	2	21998301
Pubmed	Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.	NCK1 NCK2	7.99e-05	6	81	2	12091389
Pubmed	Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration.	NCK1 NCK2	7.99e-05	6	81	2	25691664
Pubmed	Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.	NCK1 NCK2	1.12e-04	7	81	2	12074588
Pubmed	Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients.	NPHS1 ACE	1.12e-04	7	81	2	19520069
Pubmed	The DNA sequence and analysis of human chromosome 14.	POMT2 DHRS7 YLPM1 PPP1R13B	1.35e-04	111	81	4	12508121
Pubmed	Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.	NCK1 NCK2	1.49e-04	8	81	2	26659946
Pubmed	Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.	NCK1 NCK2	1.49e-04	8	81	2	10026169
Pubmed	Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.	NCK1 NCK2	1.91e-04	9	81	2	10428862
Pubmed	The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε.	DTX4 IRF3	1.91e-04	9	81	2	34908452
Pubmed	The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.	NCK1 NCK2	1.91e-04	9	81	2	11557983
Pubmed	Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.	NCK1 NCK2	1.91e-04	9	81	2	15110774
Pubmed	Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.	PKD1 PKD1L2	2.38e-04	10	81	2	16805797
Pubmed	Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.	NPHS1 NCK1	2.38e-04	10	81	2	22840396
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LPIN3 MFHAS1 RRS1 PKD1 TMEM187 LRRK1 ARHGEF4 PRRT4 MED13 NCK2	2.45e-04	1105	81	10	35748872
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LMF2 KIDINS220 GHDC DHRS7 TM9SF1 NUS1 LMAN2 VARS1 SEMA4C	3.45e-04	942	81	9	31073040
Pubmed	Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts.	PPP1R13B DIDO1	4.79e-04	14	81	2	26201719
Pubmed	Protein phosphatase 1α interacting proteins in the human brain.	YLPM1 PPP1R13B PPP1R13L	5.24e-04	67	81	3	22321011
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	TMPRSS9 WDR6 RRS1 NUS1 IRF3 LMAN2 NCK1 CARNS1 TEDC1	6.15e-04	1021	81	9	26760575
Pubmed	USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.	WDR6 PRMT2 VARS1	6.73e-04	73	81	3	30224337
Pubmed	JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.	WDR6 IRF3	8.00e-04	18	81	2	33684176
Pubmed	Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation.	GUSB CLN5	8.93e-04	19	81	2	29514215
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	NCK1 LRRK1 NCK2	9.11e-04	81	81	3	20697350
Pubmed	Identification and proteomic profiling of exosomes in human urine.	PKD1 ACE	1.09e-03	21	81	2	15326289
Pubmed	Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.	NPHS1 PKD1	1.09e-03	21	81	2	27591083
Pubmed	Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.	CLEC4G PKD1 GIMAP1 VARS1	1.20e-03	198	81	4	27480124
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	HTRA2 MFHAS1 WDR6 YLPM1 LMAN2 PPP1R13L MED13 NCK2	1.38e-03	922	81	8	27609421
Pubmed	IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.	TMEM160 UQCR11	1.43e-03	24	81	2	25863250
Pubmed	Defining the membrane proteome of NK cells.	LMF2 KIDINS220 GHDC GUSB DHRS7 GYS1 TAP1 ALG12 MED13	1.58e-03	1168	81	9	19946888
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WDR6 YLPM1 PPP1R13B DIDO1 NCK1 JMJD1C	1.80e-03	549	81	6	38280479
Pubmed	Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.	LMF2 MFHAS1 DIDO1 LRRK1	2.08e-03	230	81	4	29513927
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	WDR6 GYS1 YLPM1 PPP1R13B ATP10B PPP1R13L	2.23e-03	573	81	6	28330616
Interaction	MAP4K1 interactions	WDR6 DTX4 IRF3 NCK1 LRRK1 CUL7 NCK2	5.97e-07	130	76	7	int:MAP4K1
GeneFamily	Dolichyl D-mannosyl phosphate dependent mannosyltransferases\|Phosphatidylinositol glycan anchor biosynthesis	POMT2 ALG12	3.00e-04	9	53	2	430
GeneFamily	C-type lectin domain family	CLEC4F CLEC4G KLRG1	3.52e-04	47	53	3	494
GeneFamily	CD molecules\|Mucins	MUC3B MUC3A	1.71e-03	21	53	2	648
Coexpression	GSE22432_PDC_VS_TGFB1_TREATEDCOMMON_DC_PROGENITOR_DN	ARHGAP6 KIDINS220 CFP LRRK1 CARNS1 TAP1 JMJD1C	2.69e-06	200	80	7	M7833
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	POMT2 LMF2 MFHAS1 GUSB TM9SF1 TAF1C LMAN2 ALG12 VARS1 FBXL6 SEMA4C	6.92e-06	681	80	11	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	POMT2 LMF2 MFHAS1 GUSB TM9SF1 TAF1C LMAN2 ALG12 VARS1 FBXL6 SEMA4C	9.32e-06	703	80	11	MM1055
Coexpression	GSE27786_LIN_NEG_VS_ERYTHROBLAST_UP	KIDINS220 DNLZ HTRA2 NCK1 UQCR11 JMJD1C	3.44e-05	200	80	6	M4790
Disease	Albuminuria	NPHS1 NCK1 ACE NCK2	4.85e-07	24	79	4	C0001925
Disease	Proteinuria	NPHS1 GUSB NCK1 NCK2	5.42e-06	43	79	4	C0033687
Disease	Autistic Disorder	ADSL TAF1C CUL7 ACE JMJD1C	6.89e-04	261	79	5	C0004352
Disease	allergic disease (is_implicated_in)	ACE TAP1	7.27e-04	15	79	2	DOID:1205 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 ACE	8.29e-04	16	79	2	DOID:0110861 (implicated_via_orthology)
Disease	ankylosing spondylitis (is_implicated_in)	ACE TAP1	1.18e-03	19	79	2	DOID:7147 (is_implicated_in)
Disease	nephrotic syndrome (implicated_via_orthology)	NPHS1 ACE	1.88e-03	24	79	2	DOID:1184 (implicated_via_orthology)
Disease	lipid measurement, intermediate density lipoprotein measurement	HAPLN4 KLRG1 JMJD1C	2.21e-03	96	79	3	EFO_0004529, EFO_0008595
Disease	Nephrotic Syndrome	NCK1 NCK2	2.38e-03	27	79	2	C0027726
Disease	phospholipid measurement, intermediate density lipoprotein measurement	HAPLN4 KLRG1 JMJD1C	2.41e-03	99	79	3	EFO_0004639, EFO_0008595
Disease	lysophosphatidylcholine 18:2 measurement	AFDN-DT CCDC85A	2.56e-03	28	79	2	EFO_0010361

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLVEWWAQERGWRLA	C1orf167	951	Q5SNV9
RQTTADWWWGERAGC	PRMT2	61	P55345
EDLLWAWEGWRDKAG	ACE	781	P12821
DRWAWRHRYGAQGRW	AFDN-DT	186	Q9Y6Z5
ATNREWWWGRVADGE	ARHGEF4	226	Q9NR80
LSGWRWRGRQAWRLH	CARNS1	166	A5YM72
EWRGRWSDGSQEWEE	CAPN13	281	Q6MZZ7
APRPRSAEDWWWDRL	FBXL6	16	Q8N531
SAEDWWWDRLAPRGS	FBXL6	21	Q8N531
WAEWQGRRPEWELTD	DHRS7	36	Q9Y394
AVVVWEWLNEHGRWR	DTX4	6	Q9Y2E6
RKDESETEWWWARLG	PPP1R13B	1051	Q96KQ4
ETEWWWARLGDREGY	PPP1R13B	1056	Q96KQ4
DSSWHRWQWRVRDGF	ATP10B	6	O94823
LAAWLRHEWARFIWL	ALG12	161	Q9BV10
GLVWATDWRLILDWV	UQCR11	31	O14957
WLSMRWGWDPRRAAC	KCNK6	156	Q9Y257
RERRWDRGEAWWGAE	ARL10	36	Q8N8L6
SRPRVLLRWWLGWRQ	NPHS1	366	O60500
PRKGGRWWFSWRRRD	LPIN3	521	Q9BQK8
WLVDRARVGSRWTWL	KANSL1L	371	A0AUZ9
GGRREGESWNWAWVL	KIDINS220	546	Q9ULH0
MAAEGWIWRWGWGRR	LMAN2	1	Q12907
NERLWLLDDSKSWWR	NCK1	26	P16333
NERLWLLDDSKTWWR	NCK2	26	O43639
AQRLWLSWWDSARLG	MFHAS1	676	Q9Y4C4
WCLAVWRGWGAREFD	LRRK1	1981	Q38SD2
ERWESGRGWRSWRAG	JMJD1C	26	Q15652
RSGWWGGQRRGRSWD	MUC3A	3251	Q02505
GSQRRLQWTWLGWAE	CUL7	1441	Q14999
LRVRFGTWNWIWRRC	NUS1	26	Q96E22
WGALVWAATWQRRRL	GHDC	41	Q8N2G8
LGRRRWLSRNTWGPW	FAM157C	256	P0CG43
GEWDSWGEWSPCIRR	CFP	316	P27918
QDREWWIGLTWNLAR	PKD1L2	81	Q7Z442
RLGDAGWLDWQRERW	ARHGAP6	941	O43182
GWLDWQRERWQIWEL	ARHGAP6	946	O43182
GEALRAWRASWRLSW	FCSK	516	Q8N0W3
VQRRPWGAWLSARLW	GIMAP1	251	Q8WWP7
GWSLRAWRALGGIRW	HTRA2	11	O43464
GLLALLSALGWLWWR	IGLON5	321	A6NGN9
CWIGLRNNSGWRWED	KLRG1	131	Q96E93
AGRRRAWAWGWRRSS	DNLZ	36	Q5SXM8
ISQDWRLRHFVGWVW	GUSB	86	P08236
RGGRRSAWVRNWCVW	AWAT1	61	Q58HT5
RNWSRERDWDRPREW	DIDO1	2121	Q9BTC0
EKGWGSRARRVLQWW	CCDC85A	456	Q96PX6
RRPVEAGSAEWTWGW	FAM167A-AS1	36	Q96KT0
AWRDGLDWCNAGWLR	HAPLN4	201	Q86UW8
ASAWALERWKGELWD	GYS1	121	P13807
GWNRRWRGRAWRAPY	CROCCP3	246	Q8IVE0
TVLRRDGPEETDWWW	PPP1R13L	786	Q8WUF5
PDWRAWWQRSLSLAR	ISM1	156	B1AKI9
GRWRVLRLGAWARWL	PKD1	3926	P98161
GLALWRAGQWLWAQR	IRF3	271	Q14653
SEWWGRQRRGRSWDQ	MUC3B	1166	Q9H195
MWLDRRGWLRVLGHW	RPUSD2	1	Q8IZ73
IREWCISRQLWWGHR	VARS1	716	P26640
AWGSRRFEAVGWWAL	POMT2	46	Q9UKY4
LSALWRWTQVRGWLR	LMF2	381	Q9BU23
MRSRVLWGAARWLWP	MTRF1L	1	Q9UGC7
LWGAARWLWPRRAVG	MTRF1L	6	Q9UGC7
LGEAWAGRGAAWWER	TAF1C	721	Q15572
FRTWRQLWLWLAEAE	ADSL	36	P30566
EEWLGRAGLRWTWAR	SFT2D3	41	Q587I9
RVWAVGLSRWAVLWL	TAP1	56	Q03518
RDQRPGRRELWIFWW	MED13	71	Q9UHV7
GRRELWIFWWGEDPS	MED13	76	Q9UHV7
AARLWGLGIGAEVWW	SEMA4C	11	Q9C0C4
SWSWIPGLGRDRDAW	SSC5D	581	A1L4H1
RGRASWCWALALLWL	CLN5	21	O75503
WIGLTDRGTEGSWRW	CLEC4F	526	Q8N1N0
WGRWVHWSRRPLFLA	CLEC4G	21	Q6UXB4
SRHRSWWRERWPGCL	NKAIN4	101	Q8IVV8
RAWRAGRRYDGSWTW	TMEM240	116	Q5SV17
LVWDEVSGQWRRRWG	RRS1	131	Q15050
AVLAWRRSELVFWRW	TEDC1	311	Q86SX3
WREGEDAEWRETARW	SLC4A10	126	Q6U841
GEWPWQVSLWLRRRE	TMPRSS9	836	Q7Z410
DWAEARARWGLAWEA	PRRT4	351	C9JH25
WTWAVEWLGDELERR	USP9Y	2416	O00507
SDWIWDARWLEGNIA	WDR6	116	Q9NNW5
HDGDRRGPWWDDWER	YLPM1	1256	P49750
WLRLWTQWRRAAVLD	TMEM187	101	Q14656
MGGGWWWARAARLAR	TMEM160	1	Q9NX00
GEDYRWWWRSVLSVG	TM9SF1	526	O15321