Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	KDEL sequence binding	KDELR2 KDELR3 KDELR1	1.45e-07	3	106	3	GO:0005046
GeneOntologyMolecularFunction	ER retention sequence binding	KDELR2 KDELR3 KDELR1	1.44e-06	5	106	3	GO:0046923
GeneOntologyMolecularFunction	microfilament motor activity	MYH10 MYO7A MYO9B MYH14	4.82e-05	38	106	4	GO:0000146
GeneOntologyMolecularFunction	melanocyte-stimulating hormone receptor activity	MC1R MC3R	8.35e-05	3	106	2	GO:0004980
GeneOntologyMolecularFunction	ATP-dependent activity	DHX16 MYH10 MYO7A MYO9B WRN DNAH7 ABCA5 MYH14 ERCC6L2 ABCD4 ATP11C ATP11A	1.01e-04	614	106	12	GO:0140657
GeneOntologyMolecularFunction	transporter activity	ANO2 SLC29A3 GRAMD1A ANKH RYR2 KCNH4 ITPR3 TMEM184A ABCA5 SLC50A1 SCN1A SLC5A6 SLC25A38 ABCD4 ATP11C KCNS3 ATP11A MFSD5	1.42e-04	1289	106	18	GO:0005215
GeneOntologyMolecularFunction	phosphatidylserine flippase activity	ATP11C ATP11A	2.76e-04	5	106	2	GO:0140346
GeneOntologyMolecularFunction	melanocortin receptor activity	MC1R MC3R	4.13e-04	6	106	2	GO:0004977
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH10 MYO7A MYO9B DNAH7 MYH14	4.17e-04	118	106	5	GO:0003774
GeneOntologyMolecularFunction	aminophospholipid flippase activity	ATP11C ATP11A	5.76e-04	7	106	2	GO:0015247
GeneOntologyMolecularFunction	phosphatidylethanolamine flippase activity	ATP11C ATP11A	5.76e-04	7	106	2	GO:0090555
GeneOntologyMolecularFunction	lipid transporter activity	ANO2 GRAMD1A ABCA5 ABCD4 ATP11C ATP11A	6.27e-04	196	106	6	GO:0005319
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP11C ATP11A	9.81e-04	9	106	2	GO:0090556
GeneOntologyMolecularFunction	calmodulin binding	MYH10 MYO7A MYO9B RYR2 RIT1 MYH14	1.43e-03	230	106	6	GO:0005516
GeneOntologyMolecularFunction	pyrophosphatase activity	DHX16 RAB19 MYO9B WRN DOLPP1 DNAH7 RIT1 ABCA5 ABCD4 ATP11C ATP11A RAB37	1.64e-03	839	106	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DHX16 RAB19 MYO9B WRN DOLPP1 DNAH7 RIT1 ABCA5 ABCD4 ATP11C ATP11A RAB37	1.66e-03	840	106	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DHX16 RAB19 MYO9B WRN DOLPP1 DNAH7 RIT1 ABCA5 ABCD4 ATP11C ATP11A RAB37	1.66e-03	840	106	12	GO:0016818
GeneOntologyMolecularFunction	cAMP response element binding protein binding	SIK1 CREBBP	1.78e-03	12	106	2	GO:0008140
GeneOntologyBiologicalProcess	protein retention in ER lumen	KDELR2 KDELR3 KDELR1	1.05e-05	9	105	3	GO:0006621
GeneOntologyBiologicalProcess	maintenance of protein localization in endoplasmic reticulum	KDELR2 KDELR3 KDELR1	5.58e-05	15	105	3	GO:0035437
GeneOntologyBiologicalProcess	actin filament-based movement	MYH10 MYO7A MYO9B RYR2 MYH14 SCN1A	1.33e-04	153	105	6	GO:0030048
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	PGAP3 SAMD8 PIGU PIGQ ST3GAL6 CYP4F22	1.53e-04	157	105	6	GO:0046467
GeneOntologyBiologicalProcess	siRNA-mediated post-transcriptional gene silencing	AGO1 AGO4	1.53e-04	4	105	2	GO:0140766
GeneOntologyBiologicalProcess	siRNA-mediated gene silencing by mRNA destabilization	AGO1 AGO4	1.53e-04	4	105	2	GO:0090625
GeneOntologyBiologicalProcess	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	KDELR2 KDELR3 PLPP3 KDELR1	1.53e-04	53	105	4	GO:0006890
GeneOntologyBiologicalProcess	protein lipidation	PGAP3 ATG13 PIGU PIGQ HHAT	1.67e-04	101	105	5	GO:0006497
GeneOntologyBiologicalProcess	membrane lipid metabolic process	PGAP3 SAMD8 PIGU PIGQ ST3GAL6 PLPP3 CYP4F22	1.72e-04	229	105	7	GO:0006643
GeneOntologyBiologicalProcess	lipoprotein biosynthetic process	PGAP3 ATG13 PIGU PIGQ HHAT	2.09e-04	106	105	5	GO:0042158
GeneOntologyCellularComponent	endoplasmic reticulum membrane	RNF121 KDELR2 KDELR3 OR8K1 PGAP3 SAMD8 ATG13 GRAMD1A DOLPP1 PIGU RYR2 TBC1D20 ITPR3 PIGQ LMF2 PLPP3 VKORC1L1 HHAT KDELR1 ABCD4 TM7SF2 CYP4F22 ATP11C ATP11A CYP4F3 HSD17B3 RNF145	1.83e-10	1293	106	27	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	RNF121 KDELR2 KDELR3 OR8K1 PGAP3 SAMD8 ATG13 GRAMD1A DOLPP1 PIGU RYR2 TBC1D20 ITPR3 PIGQ LMF2 PLPP3 VKORC1L1 HHAT KDELR1 ABCD4 TM7SF2 CYP4F22 ATP11C ATP11A CYP4F3 HSD17B3 RNF145	2.03e-10	1299	106	27	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	RNF121 KDELR2 KDELR3 OR8K1 PGAP3 SAMD8 ATG13 GRAMD1A DOLPP1 PIGU RYR2 TBC1D20 ITPR3 PIGQ LMF2 PLPP3 VKORC1L1 HHAT KDELR1 ABCD4 TM7SF2 CYP4F22 ATP11C ATP11A CYP4F3 HSD17B3 RNF145	3.26e-10	1327	106	27	GO:0042175
GeneOntologyCellularComponent	myosin II filament	MYH10 MYH14	7.62e-05	3	106	2	GO:0097513
GeneOntologyCellularComponent	COPI-coated vesicle membrane	KDELR2 KDELR3 KDELR1	1.16e-04	19	106	3	GO:0030663
GeneOntologyCellularComponent	myosin complex	MYH10 MYO7A MYO9B MYH14	2.29e-04	59	106	4	GO:0016459
GeneOntologyCellularComponent	Golgi membrane	RNF121 KDELR2 KDELR3 PGAP3 SAMD8 TBC1D20 ST3GAL6 PLPP3 ABCA5 SLC50A1 HHAT KDELR1	2.94e-04	721	106	12	GO:0000139
GeneOntologyCellularComponent	germinal vesicle	OOSP2 AURKA	3.77e-04	6	106	2	GO:0042585
GeneOntologyCellularComponent	chromosome passenger complex	AURKA AURKC	3.77e-04	6	106	2	GO:0032133
GeneOntologyCellularComponent	COPI-coated vesicle	KDELR2 KDELR3 KDELR1	6.19e-04	33	106	3	GO:0030137
GeneOntologyCellularComponent	cluster of actin-based cell projections	MYH10 MYO7A CDH23 ITPR3 MYH14 SLC5A6	9.68e-04	223	106	6	GO:0098862
GeneOntologyCellularComponent	RISC-loading complex	AGO1 AGO4	1.12e-03	10	106	2	GO:0070578
Domain	ER_ret_rcpt	KDELR2 KDELR3 KDELR1	1.78e-07	3	106	3	IPR000133
Domain	ER_lumen_recept	KDELR2 KDELR3 KDELR1	1.78e-07	3	106	3	PF00810
Domain	ER_LUMEN_RECEPTOR_1	KDELR2 KDELR3 KDELR1	1.78e-07	3	106	3	PS00951
Domain	ER_LUMEN_RECEPTOR_2	KDELR2 KDELR3 KDELR1	1.78e-07	3	106	3	PS00952
Domain	IQ	MYH10 MYO7A MYO9B MYH14 SCN1A	5.18e-05	71	106	5	PF00612
Domain	Myosin_head_motor_dom	MYH10 MYO7A MYO9B MYH14	6.24e-05	38	106	4	IPR001609
Domain	MYOSIN_MOTOR	MYH10 MYO7A MYO9B MYH14	6.24e-05	38	106	4	PS51456
Domain	Myosin_head	MYH10 MYO7A MYO9B MYH14	6.24e-05	38	106	4	PF00063
Domain	MYSc	MYH10 MYO7A MYO9B MYH14	6.24e-05	38	106	4	SM00242
Domain	Aur	AURKA AURKC	9.54e-05	3	106	2	IPR030616
Domain	IQ	MYH10 MYO7A MYO9B MYH14 SCN1A	9.74e-05	81	106	5	SM00015
Domain	IQ_motif_EF-hand-BS	MYH10 MYO7A MYO9B MYH14 SCN1A	1.60e-04	90	106	5	IPR000048
Domain	IQ	MYH10 MYO7A MYO9B MYH14 SCN1A	1.87e-04	93	106	5	PS50096
Domain	Argonaute_N	AGO1 AGO4	1.90e-04	4	106	2	IPR032474
Domain	Argonaute_Mid_dom	AGO1 AGO4	1.90e-04	4	106	2	IPR032473
Domain	ArgoL2	AGO1 AGO4	1.90e-04	4	106	2	IPR032472
Domain	ArgoN	AGO1 AGO4	1.90e-04	4	106	2	PF16486
Domain	ArgoMid	AGO1 AGO4	1.90e-04	4	106	2	PF16487
Domain	ArgoL2	AGO1 AGO4	1.90e-04	4	106	2	PF16488
Domain	DUF1785	AGO1 AGO4	3.16e-04	5	106	2	SM01163
Domain	Melcrt_ACTH_rcpt	MC1R MC3R	4.72e-04	6	106	2	IPR001671
Domain	RIH_assoc	RYR2 ITPR3	4.72e-04	6	106	2	PF08454
Domain	ArgoL1	AGO1 AGO4	4.72e-04	6	106	2	PF08699
Domain	RIH_assoc-dom	RYR2 ITPR3	4.72e-04	6	106	2	IPR013662
Domain	RIH_dom	RYR2 ITPR3	4.72e-04	6	106	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR3	4.72e-04	6	106	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR3	4.72e-04	6	106	2	IPR015925
Domain	ArgoL1	AGO1 AGO4	4.72e-04	6	106	2	IPR014811
Domain	-	RYR2 ITPR3	4.72e-04	6	106	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 ITPR3	4.72e-04	6	106	2	PF01365
Domain	Ins145_P3_rec	RYR2 ITPR3	4.72e-04	6	106	2	PF08709
Domain	Ion_trans_dom	RYR2 KCNH4 ITPR3 SCN1A KCNS3	4.81e-04	114	106	5	IPR005821
Domain	Ion_trans	RYR2 KCNH4 ITPR3 SCN1A KCNS3	4.81e-04	114	106	5	PF00520
Domain	PIWI	AGO1 AGO4	8.74e-04	8	106	2	PS50822
Domain	Piwi	AGO1 AGO4	8.74e-04	8	106	2	SM00950
Domain	Piwi	AGO1 AGO4	8.74e-04	8	106	2	IPR003165
Domain	Piwi	AGO1 AGO4	8.74e-04	8	106	2	PF02171
Domain	P-loop_NTPase	DHX16 RAB19 MYH10 MYO7A MYO9B WRN DNAH7 RIT1 ABCA5 MYH14 ERCC6L2 ABCD4 RAB37	1.02e-03	848	106	13	IPR027417
Domain	PAZ	AGO1 AGO4	1.12e-03	9	106	2	PS50821
Domain	PAZ	AGO1 AGO4	1.12e-03	9	106	2	SM00949
Domain	PAZ_dom	AGO1 AGO4	1.12e-03	9	106	2	IPR003100
Domain	PAZ	AGO1 AGO4	1.12e-03	9	106	2	PF02170
Domain	DEAH_ATP_HELICASE	DHX16 WRN ERCC6L2	1.30e-03	38	106	3	PS00690
Domain	MIR	RYR2 ITPR3	1.39e-03	10	106	2	PS50919
Domain	MIR	RYR2 ITPR3	1.39e-03	10	106	2	PF02815
Domain	MIR	RYR2 ITPR3	1.39e-03	10	106	2	SM00472
Domain	MIR_motif	RYR2 ITPR3	1.39e-03	10	106	2	IPR016093
Domain	-	WRN AGO1 AGO4	2.40e-03	47	106	3	3.30.420.10
Domain	P_typ_ATPase_c	ATP11C ATP11A	2.78e-03	14	106	2	IPR032630
Domain	P-type_ATPase_N	ATP11C ATP11A	2.78e-03	14	106	2	IPR032631
Domain	P-type_ATPase_IV	ATP11C ATP11A	2.78e-03	14	106	2	IPR006539
Domain	PhoLip_ATPase_C	ATP11C ATP11A	2.78e-03	14	106	2	PF16212
Domain	PhoLip_ATPase_N	ATP11C ATP11A	2.78e-03	14	106	2	PF16209
Domain	Myosin_N	MYH10 MYH14	3.19e-03	15	106	2	PF02736
Domain	Myosin_N	MYH10 MYH14	3.19e-03	15	106	2	IPR004009
Domain	-	DOLPP1 PLPP3	4.60e-03	18	106	2	1.20.144.10
Domain	Myosin_tail_1	MYH10 MYH14	4.60e-03	18	106	2	PF01576
Domain	Myosin_tail	MYH10 MYH14	4.60e-03	18	106	2	IPR002928
Domain	acidPPc	DOLPP1 PLPP3	4.60e-03	18	106	2	SM00014
Domain	Myosin-like_IQ_dom	MYH10 MYH14	5.12e-03	19	106	2	IPR027401
Domain	-	MYH10 MYH14	5.12e-03	19	106	2	4.10.270.10
Domain	P_Acid_Pase_2/haloperoxidase	DOLPP1 PLPP3	5.67e-03	20	106	2	IPR000326
Domain	PAP2	DOLPP1 PLPP3	5.67e-03	20	106	2	PF01569
Pubmed	A molecular specificity code for the three mammalian KDEL receptors.	KDELR2 KDELR3 KDELR1	2.75e-08	3	106	3	18086916
Pubmed	Cell-type-specific differences in KDEL receptor clustering in mammalian cells.	KDELR2 KDELR3 KDELR1	2.75e-08	3	106	3	32645101
Pubmed	The dynamic organisation of the secretory pathway.	KDELR2 KDELR3 KDELR1	2.75e-08	3	106	3	9118249
Pubmed	Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.	ATP11C ATP11A MERTK	1.10e-07	4	106	3	30355768
Pubmed	Defining the membrane proteome of NK cells.	MYO9B EIF3E AGPS PIGU YWHAG NUP205 ITPR3 LMF2 AGO4 MYH14 NISCH EIF3L ATP11A IFT122 MFSD5	2.65e-06	1168	106	15	19946888
Pubmed	Mutation analysis of the MYO7A and CDH23 genes in Japanese patients with Usher syndrome type 1.	MYO7A CDH23	9.20e-06	2	106	2	20844544
Pubmed	Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis.	MC1R MC3R	9.20e-06	2	106	2	32029712
Pubmed	A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.	KDELR2 KDELR1	9.20e-06	2	106	2	25682866
Pubmed	Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.	AURKA AURKC	9.20e-06	2	106	2	35255953
Pubmed	The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment.	AGO1 AGO4	9.20e-06	2	106	2	33233493
Pubmed	Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.	MC1R MC3R	9.20e-06	2	106	2	26112010
Pubmed	Structure of human glycosylphosphatidylinositol transamidase.	RNF121 PIGU	9.20e-06	2	106	2	35165458
Pubmed	Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.	AURKA AURKC	9.20e-06	2	106	2	35218477
Pubmed	Identification of Coding Variants in 10q22.1 Associated with Vitiligo in the Chinese Han Population.	SLC29A3 CDH23	9.20e-06	2	106	2	38546281
Pubmed	Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.	RYR2 ITPR3	9.20e-06	2	106	2	24285081
Pubmed	Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation.	MYO7A CDH23	9.20e-06	2	106	2	14648237
Pubmed	[Usher type I syndrome in children: genotype/phenotype correlation and cochlear implant benefits].	MYO7A CDH23	9.20e-06	2	106	2	18323324
Pubmed	KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover.	KDELR2 KDELR1	9.20e-06	2	106	2	30760704
Pubmed	Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.	MYO7A CDH23	9.20e-06	2	106	2	14609561
Pubmed	The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties.	MC1R MC3R	9.20e-06	2	106	2	21703408
Pubmed	Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.	RYR2 ITPR3	9.20e-06	2	106	2	18586264
Pubmed	Laminin stimulates and guides axonal outgrowth via growth cone myosin II activity.	MYH10 MYH14	9.20e-06	2	106	2	15880105
Pubmed	Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition.	MYH10 MYH14	9.20e-06	2	106	2	22025714
Pubmed	Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice.	MYO7A CDH23	9.20e-06	2	106	2	12121736
Pubmed	Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.	MC1R MC3R	9.20e-06	2	106	2	12626592
Pubmed	Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells.	AGO1 AGO4	9.20e-06	2	106	2	26995025
Pubmed	Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis.	MYH10 MYH14	9.20e-06	2	106	2	20861308
Pubmed	X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase.	ATP11C ATP11A	9.20e-06	2	106	2	15533723
Pubmed	Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes.	ATP11C ATP11A	9.20e-06	2	106	2	36162506
Pubmed	Melanocortin receptors form constitutive homo- and heterodimers.	MC1R MC3R	9.20e-06	2	106	2	15582585
Pubmed	Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.	MYO7A MYO9B MYH14	9.77e-06	14	106	3	8022818
Pubmed	SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.	MYH10 EIF3E YWHAG MYH14 EIF3L	1.11e-05	95	106	5	33863777
Pubmed	Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.	MYO7A MC1R HPS3	1.22e-05	15	106	3	18715234
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ATG13 EIF3E SIK1 CREBBP YWHAG PIGQ AURKA AURKC AGO1 AGO4 EIF3L MERTK	2.22e-05	910	106	12	36736316
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MYO7A MC3R PIGU RFX1 DNAH7 CREBBP RYR2 ITPR3 SYPL1 SPEN	2.64e-05	638	106	10	31182584
Pubmed	Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis.	MYH10 MYH14	2.76e-05	3	106	2	15774463
Pubmed	Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss.	MYO7A CDH23	2.76e-05	3	106	2	23770805
Pubmed	Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice.	MYO7A CDH23	2.76e-05	3	106	2	17050716
Pubmed	Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.	AURKA AURKC	2.76e-05	3	106	2	34636397
Pubmed	Survey of the frequency of USH1 gene mutations in a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%.	MYO7A CDH23	2.76e-05	3	106	2	16679490
Pubmed	Increased alpha-melanocyte-stimulating hormone (alpha-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis.	MC1R MC3R	2.76e-05	3	106	2	19889022
Pubmed	Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells.	MYO7A CDH23	2.76e-05	3	106	2	14578428
Pubmed	Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.	MYO7A CDH23	2.76e-05	3	106	2	20639393
Pubmed	Evidence indicating that the TM4, EL2, and TM5 of the melanocortin 3 receptor Do not participate in ligand binding.	MC1R MC3R	2.76e-05	3	106	2	8954958
Pubmed	Deregulation of Aurora kinase gene expression in human testicular germ cell tumours.	AURKA AURKC	2.76e-05	3	106	2	20629650
Pubmed	Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II.	MYH10 MYH14	2.76e-05	3	106	2	20685736
Pubmed	Differential Selective Pressures Experienced by the Aurora Kinase Gene Family.	AURKA AURKC	2.76e-05	3	106	2	29283376
Pubmed	SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.	AURKA AURKC	2.76e-05	3	106	2	19649632
Pubmed	Molecular cloning of a novel melanocortin receptor.	MC1R MC3R	2.76e-05	3	106	2	8463333
Pubmed	SAR156497, an exquisitely selective inhibitor of aurora kinases.	AURKA AURKC	2.76e-05	3	106	2	25369539
Pubmed	Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family.	MYH10 MYH14	2.76e-05	3	106	2	14594953
Pubmed	Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation.	WRN CREBBP	2.76e-05	3	106	2	18203716
Pubmed	Gene expression of Aurora kinases in prostate cancer and nodular hyperplasia tissues.	AURKA AURKC	2.76e-05	3	106	2	23075505
Pubmed	Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.	AURKA AURKC	2.76e-05	3	106	2	32452402
Pubmed	The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse.	MYO7A CDH23	2.76e-05	3	106	2	13336002
Pubmed	Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.	MYH10 MYH14	2.76e-05	3	106	2	15177565
Pubmed	Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.	AURKA AURKC	2.76e-05	3	106	2	28359584
Pubmed	Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis.	AURKA AURKC	2.76e-05	3	106	2	30415701
Pubmed	The aurora kinases in cell cycle and leukemia.	AURKA AURKC	2.76e-05	3	106	2	24632603
Pubmed	An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.	MYH10 PTPRA	2.76e-05	3	106	2	25631816
Pubmed	Characterization of three full-length human nonmuscle myosin II paralogs.	MYH10 MYH14	2.76e-05	3	106	2	24072716
Pubmed	Aurora A, centrosome structure, and the centrosome cycle.	AURKA AURKC	2.76e-05	3	106	2	19774610
Pubmed	Regulation of spindle and chromatin dynamics during early and late stages of oocyte maturation by aurora kinases.	AURKA AURKC	2.76e-05	3	106	2	18353803
Pubmed	Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.	AGO1 AGO4	2.76e-05	3	106	2	19946268
Pubmed	Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development.	AURKA AURKC	2.76e-05	3	106	2	31521144
Pubmed	Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development.	AURKA AURKC	2.76e-05	3	106	2	12434334
Pubmed	Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.	MYH10 MYH14	2.76e-05	3	106	2	15845534
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KDELR2 KDELR3 MYH10 SIK1 PEX11A YWHAG RYR2 NUP205 MYH14 KDELR1 ATP11C ATP11A IFT122 SIPA1L2 SPEN	3.21e-05	1442	106	15	35575683
Pubmed	Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping.	MYH10 MYH14	5.50e-05	4	106	2	18697221
Pubmed	Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.	MYO7A CDH23	5.50e-05	4	106	2	16481439
Pubmed	Novel binding motif of ACTH analogues at the melanocortin receptors.	MC1R MC3R	5.50e-05	4	106	2	19743876
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO1 AGO4	5.50e-05	4	106	2	23748378
Pubmed	Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.	AGO1 AGO4	5.50e-05	4	106	2	15260970
Pubmed	The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.	EIF3E EIF3L	5.50e-05	4	106	2	11590142
Pubmed	SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.	SIK1 CREBBP	5.50e-05	4	106	2	17468767
Pubmed	Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane.	ATP11C ATP11A	5.50e-05	4	106	2	25315773
Pubmed	Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.	MC1R MC3R	5.50e-05	4	106	2	15470082
Pubmed	Slicing-independent RISC activation requires the argonaute PAZ domain.	AGO1 AGO4	5.50e-05	4	106	2	22795694
Pubmed	ATP-dependent human RISC assembly pathways.	AGO1 AGO4	5.50e-05	4	106	2	19966796
Pubmed	Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.	AGO1 AGO4	5.50e-05	4	106	2	18771919
Pubmed	A Requirement for Argonaute 4 in Mammalian Antiviral Defense.	AGO1 AGO4	5.50e-05	4	106	2	32049003
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TTC9B GRAMD1A PIGU TBC1D20 PTPRA NISCH SLC5A6 NGEF KDELR1 TM7SF2	5.55e-05	697	106	10	28298427
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO1 AGO4	9.15e-05	5	106	2	12526743
Pubmed	Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.	MYH10 MYH14	9.15e-05	5	106	2	19439495
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO1 AGO4	9.15e-05	5	106	2	19393748
Pubmed	Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin.	MYO7A CDH23	9.15e-05	5	106	2	12588794
Pubmed	Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development.	MYH10 MYH14	9.15e-05	5	106	2	33871354
Pubmed	Interactions in the network of Usher syndrome type 1 proteins.	MYO7A CDH23	9.15e-05	5	106	2	15590703
Pubmed	Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.	MYO7A CDH23	9.15e-05	5	106	2	20332152
Pubmed	Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.	MYH10 MYH14	9.15e-05	5	106	2	25006807
Pubmed	Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population.	MYO7A CDH23	9.15e-05	5	106	2	15660226
Pubmed	Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells.	MYO7A CDH23	9.15e-05	5	106	2	16219682
Pubmed	Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells.	MYH10 MYO7A	9.15e-05	5	106	2	17615572
Pubmed	ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons.	MYH10 MYO9B	9.15e-05	5	106	2	30123108
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO1 AGO4	9.15e-05	5	106	2	16036130
Pubmed	The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.	AGO1 AGO4	9.15e-05	5	106	2	12414724
Pubmed	Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes.	MYO7A CDH23	9.15e-05	5	106	2	22381527
Pubmed	Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis.	MC1R MC3R	9.15e-05	5	106	2	12865302
Pubmed	Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium.	ATP11C ATP11A	9.15e-05	5	106	2	26567335
Pubmed	The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.	AGO1 AGO4	9.15e-05	5	106	2	19324964
Cytoband	19p13.1	MYO9B RFX1 SSBP4	1.92e-04	48	106	3	19p13.1
GeneFamily	Melanocortin receptors	MC1R MC3R	1.82e-04	5	78	2	236
GeneFamily	Argonaute/PIWI family	AGO1 AGO4	5.06e-04	8	78	2	408
GeneFamily	Eukaryotic translation initiation factor 3	EIF3E EIF3L	1.39e-03	13	78	2	1121
GeneFamily	Myosin heavy chains	MYH10 MYH14	1.86e-03	15	78	2	1098
GeneFamily	ATPase phospholipid transporting	ATP11C ATP11A	1.86e-03	15	78	2	1210
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGU PIGQ	3.66e-03	21	78	2	680
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	RNF121 KDELR2 PIGU ANKH ITPR3 LMF2 SLC50A1 NISCH SLC5A6 CD151 ATP11A TTC13 MFSD5	3.42e-06	681	105	13	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	RNF121 KDELR2 PIGU ANKH ITPR3 LMF2 SLC50A1 NISCH SLC5A6 CD151 ATP11A TTC13 MFSD5	4.82e-06	703	105	13	MM1055
Coexpression	GSE360_L_DONOVANI_VS_T_GONDII_MAC_UP	KDELR2 KDELR3 MYO7A KIAA0232 DNAH7 ST3GAL6 MFSD5	1.59e-05	199	105	7	M5233
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA0232 ECM2 TEK HHAT SLC25A38 CD151	3.37e-06	172	105	6	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDELR2 KDELR3 SAMD8 FCGBP ST3GAL6 SLC50A1	5.28e-06	186	105	6	32d30f08b20a0a28e38b37bd52ab26d1d43736ce
ToppCell	metastatic_Lymph_Node-Epithelial_cells-Malignant_cells\|Epithelial_cells / Location, Cell class and cell subclass	KDELR2 ITPR3 KDELR1 CD151 ATP11A RNF145	7.99e-06	200	105	6	b16da9c342f9ff5ed4983c65b7d3b59123a594cd
Disease	X-linked infantile spasms	SIK1 PIGQ SCN1A	2.22e-06	8	102	3	C4552072
Disease	Global developmental delay	SZT2 PIGU TBC1D20 PIGQ AGO1 SLC5A6	7.07e-06	133	102	6	C0557874
Disease	Developmental delay (disorder)	SZT2 TBC1D20 PIGQ SLC5A6	8.14e-06	37	102	4	C0424605
Disease	Early infantile epileptic encephalopathy with suppression bursts	SIK1 PIGQ SCN1A	2.17e-05	16	102	3	C0393706
Disease	Cerebral atrophy	PIGU SLC5A6	7.07e-05	4	102	2	C0235946
Disease	Usher syndrome, type 1A	MYO7A CDH23	1.18e-04	5	102	2	C2931205
Disease	USHER SYNDROME, TYPE IB (disorder)	MYO7A CDH23	1.18e-04	5	102	2	C1848638
Disease	USHER SYNDROME, TYPE IA, FORMERLY	MYO7A CDH23	1.18e-04	5	102	2	C1848639
Disease	USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY	MYO7A CDH23	1.18e-04	5	102	2	C1848640
Disease	Usher syndrome type 1	MYO7A CDH23	1.18e-04	5	102	2	cv:C1568247
Disease	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1	SIK1 SCN1A	1.76e-04	6	102	2	C3463992
Disease	beta-hydroxybutyric acid measurement	KCNS3 MERTK	1.76e-04	6	102	2	EFO_0010465
Disease	Usher Syndrome, Type I	MYO7A CDH23	1.76e-04	6	102	2	C1568247
Disease	obsolete_red blood cell distribution width	KDELR2 MYO9B KIAA0232 SPTB CDH23 ANKRD6 ZBTB24 PIGQ PTPRA EIF3L ATP11C ATP11A SSBP4 RAB37	2.22e-04	1347	102	14	EFO_0005192
Disease	Hereditary retinal dystrophy	MYO7A CDH23	2.46e-04	7	102	2	C0154860
Disease	Usher syndrome	MYO7A CDH23	2.46e-04	7	102	2	cv:C0271097
Disease	Aqueductal Stenosis	MYH10 IFT122	3.27e-04	8	102	2	C2936786
Disease	vascular endothelial growth factor receptor 3 measurement	GPR15 ST3GAL6	5.23e-04	10	102	2	EFO_0008315
Disease	Intellectual Disability	PIGU YWHAG ZBTB24 TBC1D20 AGO1 SCN1A SLC5A6	9.37e-04	447	102	7	C3714756
Disease	succinylcarnitine measurement	DOLPP1 PTPRA	1.38e-03	16	102	2	EFO_0020020
Disease	exercise test	WRN RYR2	2.16e-03	20	102	2	EFO_0004328
Disease	Nonsyndromic genetic hearing loss	MYO7A CDH23 MYH14	2.35e-03	76	102	3	cv:C5680182
Disease	Nonsyndromic Deafness	MYO7A CDH23 MYH14	2.81e-03	81	102	3	C3711374
Disease	longitudinal BMI measurement	CALCR HHAT KCNS3	2.91e-03	82	102	3	EFO_0005937

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSLLAFHYGLYFYTV	ABCA5	1086	Q8WWZ7
IRLGLALNYSVFYYE	YWHAG	171	P61981
HEYVILYRIYFGEVQ	ATG13	146	O75143
LYNYFHDARRVYLIL	AURKC	106	Q9UQB9
LYGYFHDATRVYLIL	AURKA	196	O14965
YVLYYLAIVGHSLSI	CALCR	146	P30988
IYYIFDSYIRRAIVH	GPR15	301	P49685
AYYARLVAFRARYHL	AGO1	801	Q9UL18
HRAAYEGHYLALKYL	ASB15	281	Q8WXK1
RTAVYHEILIGYLEY	CREBBP	1446	Q92793
LILGFSVAYAFYYLS	ABHD3	36	Q8WU67
TEHLHRLYFRGRAYY	ABCD4	116	O14678
YYARLVAFRARYHLV	AGO4	806	Q9HCK5
YVLAYHYRKRGVHLA	ANO2	101	Q9NQ90
YIRVRKAITAGYFYH	DHX16	936	O60231
VFYSILAIHYFRALA	CDH23	2881	Q9H251
DYFYTAHRYCILGLA	GRAMD1A	471	Q96CP6
HEFRAYQLYTLYRGK	ANKRD6	386	Q9Y2G4
YYRSAHAAIIAYDLT	RAB19	86	A4D1S5
THAYYRDAQALLLLY	RAB37	96	Q96AX2
AHELFYSILLFDLIY	ITPR3	2336	Q14573
DRYISIFYALRYHSI	MC1R	141	Q01726
RVRTHLYGSLLYYLQ	NUP205	1416	Q92621
RIHTYVYEFIYLVRD	OOSP2	61	Q86WS3
LVYLRYAYSLGEHYN	OTUD6A	256	Q7L8S5
IFSTVHGLYKDRYAY	IFT122	351	Q9HBG6
VAFLVSYSRVYLLYH	DOLPP1	146	Q86YN1
YGDLHTYLLYSRLET	MERTK	676	Q12866
AVFLILYKELYYRHI	EIF3L	126	Q9Y262
VLHNLRERYYSGLIY	MYH14	121	Q7Z406
TITTHYLFFLGLYRA	KDELR3	146	O43731
YLFFLGLYRALYLAN	KDELR3	151	O43731
IYTRYVLSLLLHDSY	KIAA0232	56	Q92628
AFDHYIAICYPLRYT	OR52B4	121	Q8NGK2
HLVRFYFLTRVYSEY	PCED1A	106	Q9H1Q7
EYLLRRGDALQAHYY	KCNH4	581	Q9UQ05
FRYVLNFYYTGKLHV	KCNS3	76	Q9BQ31
FHVLSTDYSYGLVYL	LCN10	116	Q6JVE6
FYAFLRREYYLTHGL	PIGU	406	Q9H490
GVSHLLPYFYLLYFT	TM7SF2	366	O76062
LYLTSLPFLIHYYAS	OXGR1	81	Q96P68
ELALYLLASLGFHFY	HHAT	6	Q5VTY9
TDFGLRVAYDLVYYV	FCGBP	2561	Q9Y6R7
ILRYYYYIHHGIDTD	DNAH7	161	Q8WXX0
HTLIAYSDLGYYIIN	ANKH	101	Q9HCJ1
HGFRQEYLDTLYRYA	EIF3E	121	P60228
VSFYGAYHSLRELFL	ECM2	601	O94769
DRYVTIFYALRYHSI	MC3R	141	P41968
HQQILLYIDFLYYLT	CYP4F3	236	Q08477
DYQREGTRFLYGHYI	ERCC6L2	136	Q5T890
YLFALGVYRTLYLFN	KDELR1	151	P24390
FLLEIIAGILAYAYY	CD151	101	P48509
FYSGAFQRLLLTHYV	HSD17B3	286	P37058
GYYDLLIDIHLSSYA	RYR2	1701	Q92736
TITTHYLFFLGLYRA	KDELR2	146	P33947
YLFFLGLYRALYLVN	KDELR2	151	P33947
RLHHYLDFIYYRSAD	CYP4F22	246	Q6NT55
LYQHYYFLEGQIAIL	MFSD5	66	Q6N075
VLHNLKDRYYSGLIY	MYH10	101	P35580
YVFIYQALLEHYLYG	PTPRA	491	P18433
LGLVYLIYYEESLHH	OR52N5	51	Q8NH56
YNFTLADILLYYGLH	EEF1E1	111	O43324
ADILLYYGLHRFIVD	EEF1E1	116	O43324
VSYLSLIRFDYGYNL	PGAP3	211	Q96FM1
AALLLYVGYTSLYLD	SYPL1	131	Q16563
LGLTVYHRAFLLYSF	SZT2	336	Q5T011
YHRAFLLYSFLRSGE	SZT2	341	Q5T011
GLYLLLSRLEYARYY	SLC29A3	246	Q9BZD2
FLGLHNLEYLYLEYN	SLITRK6	431	Q9H5Y7
IAFYITTRLFLYYHT	SAMD8	351	Q96LT4
KYERGLIFYINHSLY	HPS3	601	Q969F9
LAVYGLLAYGTVHYF	LMF2	321	Q9BU23
AILAIITGEFYRIYY	PLPP3	96	O14495
SFGSFHLIRLLYDEY	RFX1	871	P22670
LSLLLLGDHQYYVYF	TMEM184A	106	Q6ZMB5
FYRLHLTSAYEYLEL	SLC5A6	121	Q9Y289
IIALLTFHIYCFYVY	PIGQ	391	Q9BRB3
IVYRYAADHFSVYIT	NGEF	351	Q8N5V2
IIEHIDLGAYYYRKF	SIPA1L2	476	Q9P2F8
VAIFLSAVFLYYVLH	ST3GAL6	6	Q9Y274
YNHFAAIYYLLLERL	SIK1B	331	A0A0B4J2F2
YNHFAAIYYLLLERL	SIK1	331	P57059
YFFLRHLSITDLGYS	OR8K1	66	Q8NGG5
LYAATDAYAGFIIYR	WRN	211	Q14191
HYYYSLLLSLVRDLY	PEX11A	126	O75192
YYLTYILLHLVGEVS	SLF2	1086	Q8IX21
YGYESIYAALRSIYH	SLC25A38	156	Q96DW6
SRYHYFLEGFLDALL	SCN1A	321	P35498
IAYIRDLALEYYVLG	AGPS	511	O00116
HGHFYYIRISELVQY	ATP11A	871	P98196
GHLYYVRIAHLVQYF	ATP11C	866	Q8NB49
LYRHRGTLYFISEDY	TTC13	251	Q8NBP0
LAEYYGLYRDLFHGA	MRPL38	151	Q96DV4
ELFQEYRYGDIRTYH	SPEN	3301	Q96T58
AYRYYIDDVFHALVR	RIT1	166	Q92963
LALYVYEYLLHIGAQ	SSBP4	21	Q9BWG4
FLLIKRSGYREYEHY	STAP1	31	Q9ULZ2
GAALQTLYILAYLHY	SLC50A1	76	Q9BRV3
AVYFVLHDGLRRYFS	NISCH	1186	Q9Y2I1
SLLFYGLYYGVLERD	RNF121	181	Q9H920
QLLAASYDLHRYFYT	SPTB	1791	P11277
SYDLHRYFYTGAEIL	SPTB	1796	P11277
ACEHRGYLYLAIEYA	TEK	891	Q02763
VVGSLYLAYILYFVL	VKORC1L1	121	Q8N0U8
TFGILLEFIYTGYLH	ZBTB24	86	O43167
HYYQGYHDIVVTFLL	TBC1D20	141	Q96BZ9
TRAGLYYLYCQVHFD	TNFSF12	156	O43508
YLYFLTALLLYAGHQ	RNF145	81	Q96MT1
FYHLGDYARALRYLQ	TTC9B	181	Q8N6N2
QSLYLHRYYFEVEIF	TRIM16L	206	Q309B1
LIRYRDHLIYTYTGS	MYO7A	86	Q13402
DERNYHVFYYLLLGV	MYO9B	331	Q13459