Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved SA node cell action potential	CACNA1D CACNA1G	8.58e-06	2	59	2	GO:0086059
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1D CACNA1F CACNA1G	8.71e-06	14	59	3	GO:0008331
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1D CACNA1G	8.53e-05	5	59	2	GO:0086007
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1D CACNA1F CACNA1G	3.40e-04	46	59	3	GO:0005245
GeneOntologyBiologicalProcess	membrane depolarization during SA node cell action potential	CACNA1D CACNA1G	7.73e-05	5	58	2	GO:0086046
GeneOntologyBiologicalProcess	heme O biosynthetic process	ALAS1 UROD	2.76e-04	9	58	2	GO:0048034
GeneOntologyBiologicalProcess	heme O metabolic process	ALAS1 UROD	2.76e-04	9	58	2	GO:0048033
GeneOntologyBiologicalProcess	heme B metabolic process	ALAS1 UROD	2.76e-04	9	58	2	GO:0046492
GeneOntologyBiologicalProcess	protoporphyrinogen IX biosynthetic process	ALAS1 UROD	2.76e-04	9	58	2	GO:0006782
GeneOntologyBiologicalProcess	heme B biosynthetic process	ALAS1 UROD	2.76e-04	9	58	2	GO:0006785
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1D CACNA1F CACNA1G	3.34e-04	48	58	3	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1D CACNA1F CACNA1G	3.34e-04	48	58	3	GO:1902656
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell signaling	CACNA1D CACNA1G	3.45e-04	10	58	2	GO:0086018
GeneOntologyBiologicalProcess	SA node cell action potential	CACNA1D CACNA1G	3.45e-04	10	58	2	GO:0086015
GeneOntologyBiologicalProcess	heme a metabolic process	ALAS1 UROD	3.45e-04	10	58	2	GO:0046160
GeneOntologyBiologicalProcess	heme A biosynthetic process	ALAS1 UROD	3.45e-04	10	58	2	GO:0006784
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell communication	CACNA1D CACNA1G	4.21e-04	11	58	2	GO:0086070
GeneOntologyBiologicalProcess	protoporphyrinogen IX metabolic process	ALAS1 UROD	4.21e-04	11	58	2	GO:0046501
MousePheno	neuron degeneration	CACNA1D CACNA1F INPP4A PCARE CACNA1G DRAM2 RTBDN HERC2 ASIC3	6.10e-06	391	48	9	MP:0003224
MousePheno	neurodegeneration	CACNA1D CACNA1F INPP4A PCARE CACNA1G DRAM2 RTBDN HERC2 ASIC3	2.57e-05	468	48	9	MP:0002229
Domain	VDCCAlpha1	CACNA1D CACNA1F CACNA1G	3.36e-06	10	58	3	IPR002077
Domain	CAC1F_C	CACNA1D CACNA1F	2.84e-05	3	58	2	IPR031688
Domain	CAC1F_C	CACNA1D CACNA1F	2.84e-05	3	58	2	PF16885
Domain	VDCC_L_a1su	CACNA1D CACNA1F	5.66e-05	4	58	2	IPR005446
Domain	VDCC_a1su_IQ	CACNA1D CACNA1F	1.97e-04	7	58	2	IPR014873
Domain	GPHH	CACNA1D CACNA1F	1.97e-04	7	58	2	PF16905
Domain	GPHH_dom	CACNA1D CACNA1F	1.97e-04	7	58	2	IPR031649
Domain	Ca_chan_IQ	CACNA1D CACNA1F	1.97e-04	7	58	2	SM01062
Domain	Ca_chan_IQ	CACNA1D CACNA1F	1.97e-04	7	58	2	PF08763
Domain	-	SLIT2 FBXL13 LINGO3 FBXO33 LRRN4 NLRP6	4.70e-04	321	58	6	3.80.10.10
Domain	L_dom-like	SLIT2 FBXL13 LINGO3 FBXO33 LRRN4 NLRP6	5.26e-04	328	58	6	IPR032675
Domain	Channel_four-helix_dom	CACNA1D CACNA1F CACNA1G	7.38e-04	57	58	3	IPR027359
Domain	-	CACNA1D CACNA1F CACNA1G	7.38e-04	57	58	3	1.20.120.350
Domain	Cys-rich_flank_reg_C	SLIT2 LINGO3 LRRN4	2.76e-03	90	58	3	IPR000483
Domain	LRRCT	SLIT2 LINGO3 LRRN4	2.76e-03	90	58	3	SM00082
Domain	LRR_1	SLIT2 FBXL13 LINGO3 LRRN4	4.76e-03	219	58	4	PF00560
Domain	AAA	FIGNL2 PSMC2	4.99e-03	34	58	2	PS00674
Domain	Ion_trans_dom	CACNA1D CACNA1F CACNA1G	5.35e-03	114	58	3	IPR005821
Domain	Ion_trans	CACNA1D CACNA1F CACNA1G	5.35e-03	114	58	3	PF00520
Domain	PRY	TRIM21 RNF39	7.54e-03	42	58	2	PF13765
Domain	SAM_2	PPFIBP1 ANKS1A	7.89e-03	43	58	2	PF07647
Domain	PRY	TRIM21 RNF39	9.76e-03	48	58	2	SM00589
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1D CACNA1F CACNA1G	2.40e-05	23	35	3	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1D CACNA1F CACNA1G	3.11e-05	25	35	3	M47948
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1D CACNA1F	8.93e-05	6	35	2	M47762
Pathway	WP_HEME_BIOSYNTHESIS	ALAS1 UROD	2.13e-04	9	35	2	M39470
Pathway	KEGG_MEDICUS_REFERENCE_HEME_BIOSYNTHESIS	ALAS1 UROD	2.13e-04	9	35	2	M47606
Pathway	WP_HEMESYNTHESIS_DEFECTS_AND_PORPHYRIAS	ALAS1 UROD	2.13e-04	9	35	2	M45555
Pathway	WP_HEME_BIOSYNTHESIS	ALAS1 UROD	2.13e-04	9	35	2	MM15895
Pathway	BIOCARTA_AHSP_PATHWAY	ALAS1 UROD	4.59e-04	13	35	2	M19553
Pathway	REACTOME_HEME_BIOSYNTHESIS	ALAS1 UROD	4.59e-04	13	35	2	MM14720
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1D CACNA1F	5.35e-04	14	35	2	M47692
Pathway	REACTOME_HEME_BIOSYNTHESIS	ALAS1 UROD	5.35e-04	14	35	2	M27059
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1D CACNA1F ADRB3 CACNA1G	9.48e-04	178	35	4	M2890
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1D CACNA1F CACNA1G	1.62e-07	7	59	3	12900400
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1D CACNA1F CACNA1G	2.58e-07	8	59	3	28330839
Pubmed	Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity.	CACNA1D CACNA1G	2.83e-06	2	59	2	33144668
Pubmed	C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.	CACNA1D CACNA1F	2.83e-06	2	59	2	16921373
Pubmed	Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.	CACNA1D CACNA1F	2.83e-06	2	59	2	25966695
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1D CACNA1G	8.48e-06	3	59	2	24966091
Pubmed	Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.	CACNA1D CACNA1G	8.48e-06	3	59	2	21406960
Pubmed	Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia.	CACNA1D CACNA1G	8.48e-06	3	59	2	32555258
Pubmed	Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.	CACNA1D CACNA1F	8.48e-06	3	59	2	26024096
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1D CACNA1F	1.69e-05	4	59	2	20937870
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1D CACNA1G	2.82e-05	5	59	2	12060068
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1D CACNA1F CACNA1G	3.75e-05	38	59	3	30786075
Pubmed	Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.	ADRB3 SIGLEC1	5.91e-05	7	59	2	21282381
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	ZBTB32 TRIM21 FBXO33 KLHL18	9.12e-05	138	59	4	28786561
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	THEM6 DNAJC10 MRPL44 RARS2 ALAS1 HERC2	9.88e-05	438	59	6	32628020
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1F CACNA1G	1.01e-04	9	59	2	16382099
Pubmed	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain.	HERC2 ANKS1A	1.26e-04	10	59	2	29097665
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1D CACNA1F	1.54e-04	11	59	2	18809727
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	THEM6 RIN1 PPFIBP1 RARS2 HERC2 UROD TBCD	2.10e-04	719	59	7	35337019
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	ZSWIM8 METTL25B DNAJC10 INPP4A TRIM21	2.67e-04	336	59	5	31253590
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1D CACNA1F	2.93e-04	15	59	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1D CACNA1F	2.93e-04	15	59	2	24453333
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SLIT2 THEM6 RIN1 GPAA1 PPFIBP1 PCARE FANCL FAM53C TBCD	3.64e-04	1321	59	9	27173435
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1D CACNA1G	3.79e-04	17	59	2	27725084
Pubmed	TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.	TRIM21 HERC2	4.25e-04	18	59	2	34729304
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	PSMC2 HERC2	4.75e-04	19	59	2	24743594
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	DNAJC10 PSMC2 RARS2 TRIM21 HERC2	4.85e-04	383	59	5	29331416
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	RIN1 MRPL44 TRIM21 TBCD	4.87e-04	214	59	4	22199357
Pubmed	Functional proteomics mapping of a human signaling pathway.	INPP4A PSMC2 FAM161B HERC2 SKIL TBCD	4.93e-04	591	59	6	15231748
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLIT2 ZSWIM8 DNAJC10 RARS2 SIGLEC1 SKIL FAM53C UNC80	5.70e-04	1116	59	8	31753913
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	TRIM21 HERC2	5.82e-04	21	59	2	37422473
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	FANCL TRIM21	6.39e-04	22	59	2	24981174
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	CACNA1F PCARE RTBDN ASIC3	6.69e-04	233	59	4	32290105
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	CCDC142 THEM6 DNAJC10 C1QTNF1 DRAM2	8.17e-04	430	59	5	16303743
Pubmed	Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.	ZBTB32 KLHL18	9.66e-04	27	59	2	30404837
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	MRPL44 ALAS1 HERC2 KLHL18 ANKS1A	1.00e-03	450	59	5	16751776
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SLIT2 ZSWIM8 DNAJC10 INPP4A HERC2	1.27e-03	475	59	5	31040226
Pubmed	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	PSMC2 HERC2	1.62e-03	35	59	2	30257870
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	ZSWIM8 PSMC2 TRIM21	1.69e-03	138	59	3	23438482
Cytoband	17q22	CACNA1G HSF5	1.48e-03	44	59	2	17q22
GeneFamily	Calcium voltage-gated channel subunits	CACNA1D CACNA1F CACNA1G	1.99e-05	26	37	3	253
Drug	Cinnarizine	CACNA1D CACNA1F CACNA1G	1.37e-06	9	59	3	DB00568
Drug	Mibefradil	CACNA1D CACNA1F CACNA1G	2.69e-06	11	59	3	DB01388
Drug	PAME	FANCL DMPK	6.60e-06	2	59	2	CID000016365
Drug	Verapamil	CACNA1D CACNA1F CACNA1G	9.04e-06	16	59	3	DB00661
Drug	N-methylprotoporphyrin	ALAS1 SIGLEC1 UROD	2.13e-05	21	59	3	CID000119311
Disease	porphyria (biomarker_via_orthology)	ALAS1 UROD	3.54e-06	2	56	2	DOID:13268 (biomarker_via_orthology)
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1D CACNA1F	2.12e-05	4	56	2	DOID:0060173 (implicated_via_orthology)
Disease	Cone-Rod Dystrophy 2	CACNA1F DRAM2	1.39e-03	29	56	2	C3489532
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1D CACNA1F	2.14e-03	36	56	2	DOID:11723 (implicated_via_orthology)
Disease	Mental Retardation, Psychosocial	INPP4A CACNA1G TBCD	2.36e-03	139	56	3	C0025363
Disease	Profound Mental Retardation	INPP4A CACNA1G TBCD	2.36e-03	139	56	3	C0020796
Disease	Mental deficiency	INPP4A CACNA1G TBCD	2.36e-03	139	56	3	C0917816
Disease	Malignant Head and Neck Neoplasm	FANCL UROD	3.18e-03	44	56	2	C0278996

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPRELARRLLCPSAQ	URAD	131	A6NGE7
RCPFREPQSILRALD	ABCG4	596	Q9H172
ELIRCLQQRAAPSRP	C1orf216	211	Q8TAB5
LREPRLRRIFCQPAD	CCDC142	406	Q17RM4
PPRFSQLRCQDLLSQ	ANKS1A	841	Q92625
AARSSPAQPRLCQRL	ADRB3	386	P13945
PLLRCPSQRLLDRVV	DIPK2B	171	Q9H7Y0
LPRSRSQTCLPELLR	INPP4A	846	Q96PE3
QRSPRALFCLTLANP	CACNA1F	66	O60840
CELTLQPLRRFPLDA	UROD	66	P06132
RALARLVLRLNAPLC	GPAA1	11	O43292
RRCPFLSRVPQAFLQ	ALAS1	6	P13196
INNFEPNCLRRRPSD	PPFIBP1	781	Q86W92
PLLPLLQRFQSIICR	HERC2	336	O95714
LRICLRVSPAEQPRL	FBXO33	111	Q7Z6M2
VFLELIRACRLPPRI	GPATCH3	201	Q96I76
PCPINNERTRLLSRD	DRAM2	251	Q6UX65
FFRPCRLLPTKNNVR	NOL6	261	Q9H6R4
LSRNRIRCLNPGDLA	LINGO3	61	P0C6S8
FLLRTANLRHPQRPC	FAM161B	401	Q96MY7
PLENPCQGRARLLLT	METTL25B	241	Q96FB5
LCNINPLRRSRLTPN	ASIC3	91	Q9UHC3
RDFIQRLLCPPETRL	DMPK	311	Q09013
NIRLPLCRPQFLSDR	KLHL18	226	O94889
RPSQDQGLPASRCLR	C1QTNF1	61	Q9BXJ1
LLRNRCFLPENFSLP	CACNA1G	236	O43497
PLQNCDPIESRLRKR	EFCAB6	1306	Q5THR3
LNVLRLNFRGCLLRP	FBXL13	221	Q8NEE6
RLLQAAFAAARCRPP	FIGNL2	471	A6NMB9
PPCRALLPELRRASN	DNAJC10	481	Q8IXB1
RNLPRSRSQPCDLDA	FAM53C	266	Q9NYF3
RPARALFCLSLNNPI	CACNA1D	101	Q01668
PRLQGDLRNLCRLAR	NLRP6	436	P59044
LANRNLERLPGCLPR	LRRN4	61	Q8WUT4
LCALNPLPFLRRTAS	PCARE	1181	A6NGG8
FRLRLLGVRQAQPLC	RTBDN	101	Q9BSG5
VQLLLSDCPPDRLRR	PIF1	101	Q9H611
RDIRFELLARLCPNS	PSMC2	366	P35998
RRAIACQLSRVLNLP	RARS2	6	Q5T160
CRPPNRFQRLLITSA	HSF5	146	Q4G112
FQKELERQRLLRCPP	MRPL44	41	Q9H9J2
SQTERLPPCQLLRRE	RIN1	276	Q13671
RLPCAVLRARLLQPR	THEM6	26	Q8WUY1
AQRLCNALLRPRTFP	SKIL	226	P12757
RRSLSLNRLLLVPCP	SPATA5L1	91	Q9BVQ7
ASLLRQCPLLLPQNR	FANCL	6	Q9NW38
LPRSFDNCPRVRLRA	GNRHR2	161	Q96P88
IADQLERRFIPRPLC	UNC80	2876	Q8N2C7
PTRPACLLRQALFAL	TAS1R1	626	Q7RTX1
RPFQCDLCRKRFLQP	ZSCAN5B	381	A6NJL1
LILSYNRLRCIPPRT	SLIT2	806	O94813
LLLCRVDSDPPARLQ	SIGLEC1	621	Q9BZZ2
CPVCRQRFLLKNLRP	TRIM21	51	P19474
RRCFPARAPLLRVAL	TMEM87B	16	Q96K49
VLDPALSPQRRRELC	ZSWIM8	431	A7E2V4
RNRLCDLLGVPRPQL	TBCD	1171	Q9BTW9
RLVQLAARLRPALCD	ZBTB32	16	Q9Y2Y4
CFRRPDNLSLALPVT	WSCD2	236	Q2TBF2
AELLQDICRRRPPLA	VMAC	101	Q2NL98
LPCPRRSLRSNVRLA	RNF39	136	Q9H2S5