Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2B2 ATP2B3 ATP2B4	1.08e-05	11	82	3	GO:0005388
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN8A	2.35e-05	14	82	3	GO:0031402
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A KCNJ8 SCN2A	4.35e-05	17	82	3	GO:0099508
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	KCNJ8 ATP2B2 ATP2B3 ATP2B4 ABCC10	8.63e-05	109	82	5	GO:0042626
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	KCNJ8 ATP2B2 ATP2B3 ATP2B4	1.23e-04	62	82	4	GO:0019829
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN8A	1.62e-04	26	82	3	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN8A	1.62e-04	26	82	3	GO:0031420
GeneOntologyMolecularFunction	calmodulin binding	CAMKK1 SCN2A ATP2B2 ATP2B3 ATP2B4 IQCG	3.69e-04	230	82	6	GO:0005516
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP2B2 ATP2B3 ATP2B4	4.32e-04	36	82	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP2B2 ATP2B3 ATP2B4	4.32e-04	36	82	3	GO:0015662
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1F SCN1A KCNJ8 SCN2A SCN8A ATP2B2 ATP2B3 ATP2B4	6.43e-04	465	82	8	GO:0046873
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	KCNJ8 ATP2B2 ATP2B3 ATP2B4 ABCC10	8.34e-04	178	82	5	GO:0015399
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN8A	1.28e-03	52	82	3	GO:0005272
GeneOntologyBiologicalProcess	heart contraction	NPPA SCN1A KCNJ8 SCN2A SCN8A ATP2B2 ATP2B3 ATP2B4	2.23e-05	298	81	8	GO:0060047
GeneOntologyBiologicalProcess	heart process	NPPA SCN1A KCNJ8 SCN2A SCN8A ATP2B2 ATP2B3 ATP2B4	2.89e-05	309	81	8	GO:0003015
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN8A	3.80e-05	17	82	3	GO:0001518
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	6.32e-05	20	82	3	GO:0033268
GeneOntologyCellularComponent	synaptic membrane	NLGN3 SCN1A KCNJ8 SCN2A SCN8A RNF10 HIP1R ATP2B2 ATP2B3 ATP2B4	9.29e-05	583	82	10	GO:0097060
GeneOntologyCellularComponent	myofibril	FLNC SCN1A KCNJ8 ANKRD1 SCN8A DCTN4 ATP2B4	9.90e-05	273	82	7	GO:0030016
GeneOntologyCellularComponent	presynaptic membrane	SCN1A KCNJ8 SCN2A SCN8A ATP2B2 ATP2B3 ATP2B4	1.08e-04	277	82	7	GO:0042734
GeneOntologyCellularComponent	contractile muscle fiber	FLNC SCN1A KCNJ8 ANKRD1 SCN8A DCTN4 ATP2B4	1.44e-04	290	82	7	GO:0043292
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	1.97e-04	29	82	3	GO:0043194
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN8A	1.97e-04	29	82	3	GO:0034706
GeneOntologyCellularComponent	presynaptic active zone membrane	KCNJ8 SCN8A ATP2B2 ATP2B4	2.52e-04	78	82	4	GO:0048787
GeneOntologyCellularComponent	sarcomere	FLNC SCN1A ANKRD1 SCN8A DCTN4 ATP2B4	4.42e-04	249	82	6	GO:0030017
GeneOntologyCellularComponent	I band	FLNC SCN1A ANKRD1 SCN8A ATP2B4	4.95e-04	166	82	5	GO:0031674
GeneOntologyCellularComponent	parallel fiber to Purkinje cell synapse	SCN8A ATP2B2 ATP2B3	6.41e-04	43	82	3	GO:0098688
GeneOntologyCellularComponent	excitatory synapse	NLGN3 SCN8A ATP2B2 ATP2B3	8.35e-04	107	82	4	GO:0060076
GeneOntologyCellularComponent	sarcolemma	FLNC SCN1A KCNJ8 SCN2A ATP2B4	9.12e-04	190	82	5	GO:0042383
GeneOntologyCellularComponent	neuronal cell body	CACNA1F NLGN3 NPPA HMCN2 G3BP1 AGER SCN1A SCN8A HIP1R ATP2B2	1.56e-03	835	82	10	GO:0043025
GeneOntologyCellularComponent	presynaptic active zone	KCNJ8 SCN8A ATP2B2 ATP2B4	2.31e-03	141	82	4	GO:0048786
GeneOntologyCellularComponent	cation channel complex	CACNA1F SCN1A KCNJ8 SCN2A SCN8A	2.32e-03	235	82	5	GO:0034703
GeneOntologyCellularComponent	Z disc	FLNC SCN1A SCN8A ATP2B4	2.96e-03	151	82	4	GO:0030018
GeneOntologyCellularComponent	fibrillar center	AGER ANKRD1 RREB1 POLR1G	3.32e-03	156	82	4	GO:0001650
GeneOntologyCellularComponent	cell body	CACNA1F NLGN3 NPPA HMCN2 G3BP1 AGER SCN1A SCN8A HIP1R ATP2B2	3.38e-03	929	82	10	GO:0044297
GeneOntologyCellularComponent	T-tubule	SCN1A SCN2A ATP2B4	3.71e-03	79	82	3	GO:0030315
GeneOntologyCellularComponent	cytoplasmic dynein complex	NUDCD3 DCTN4	3.97e-03	24	82	2	GO:0005868
Domain	NUT	NUTM2B NUTM2A NUTM2F NUTM2G	1.72e-09	5	82	4	IPR024310
Domain	NUT_N	NUTM2B NUTM2A NUTM2F NUTM2G	1.72e-09	5	82	4	IPR024309
Domain	NUT	NUTM2B NUTM2A NUTM2F NUTM2G	1.72e-09	5	82	4	PF12881
Domain	ATP_Ca_trans_C	ATP2B2 ATP2B3 ATP2B4	3.25e-07	4	82	3	IPR022141
Domain	ATP_Ca_trans_C	ATP2B2 ATP2B3 ATP2B4	3.25e-07	4	82	3	PF12424
Domain	P-type_ATPase_IIB	ATP2B2 ATP2B3 ATP2B4	3.25e-07	4	82	3	IPR006408
Domain	Na_trans_cytopl	SCN1A SCN2A SCN8A	1.62e-06	6	82	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN8A	1.62e-06	6	82	3	IPR024583
Domain	Na_channel_asu	SCN1A SCN2A SCN8A	9.57e-06	10	82	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN8A	9.57e-06	10	82	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN8A	9.57e-06	10	82	3	PF06512
Domain	Mt_Rho_GTPase	RHOT2 RHOT1	1.90e-05	2	82	2	IPR021181
Domain	EF_assoc_2	RHOT2 RHOT1	1.90e-05	2	82	2	PF08356
Domain	EF_assoc_1	RHOT2 RHOT1	1.90e-05	2	82	2	PF08355
Domain	EF_hand_assoc_2	RHOT2 RHOT1	1.90e-05	2	82	2	IPR013567
Domain	EF_hand_assoc_1	RHOT2 RHOT1	1.90e-05	2	82	2	IPR013566
Domain	MIRO_dom	RHOT2 RHOT1	1.90e-05	2	82	2	IPR020860
Domain	MIRO	RHOT2 RHOT1	1.90e-05	2	82	2	PS51423
Domain	Utp14	UTP14A UTP14C	1.90e-05	2	82	2	PF04615
Domain	SSU_processome_Utp14	UTP14A UTP14C	1.90e-05	2	82	2	IPR006709
Domain	-	ATP2B2 ATP2B3 ATP2B4	4.38e-05	16	82	3	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2B2 ATP2B3 ATP2B4	4.38e-05	16	82	3	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2B2 ATP2B3 ATP2B4	5.31e-05	17	82	3	IPR006068
Domain	Cation_ATPase_C	ATP2B2 ATP2B3 ATP2B4	5.31e-05	17	82	3	PF00689
Domain	Cation_ATPase_N	ATP2B2 ATP2B3 ATP2B4	6.35e-05	18	82	3	PF00690
Domain	Cation_ATPase_N	ATP2B2 ATP2B3 ATP2B4	6.35e-05	18	82	3	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2B2 ATP2B3 ATP2B4	7.51e-05	19	82	3	IPR004014
Domain	Channel_four-helix_dom	CACNA1F SCN1A SCN2A SCN8A	1.14e-04	57	82	4	IPR027359
Domain	-	CACNA1F SCN1A SCN2A SCN8A	1.14e-04	57	82	4	1.20.120.350
Domain	IQ	SCN1A SCN2A SCN8A IQCG	4.44e-04	81	82	4	SM00015
Domain	ATPase_P-typ_cyto_domN	ATP2B2 ATP2B3 ATP2B4	4.82e-04	35	82	3	IPR023299
Domain	P_typ_ATPase	ATP2B2 ATP2B3 ATP2B4	5.25e-04	36	82	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP2B2 ATP2B3 ATP2B4	5.25e-04	36	82	3	IPR018303
Domain	ATPASE_E1_E2	ATP2B2 ATP2B3 ATP2B4	5.25e-04	36	82	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2B2 ATP2B3 ATP2B4	5.69e-04	37	82	3	IPR008250
Domain	E1-E2_ATPase	ATP2B2 ATP2B3 ATP2B4	5.69e-04	37	82	3	PF00122
Domain	BROMODOMAIN_1	BRD8 BRD9 ASH1L	5.69e-04	37	82	3	PS00633
Domain	Bromodomain	BRD8 BRD9 ASH1L	6.16e-04	38	82	3	PF00439
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN8A IQCG	6.62e-04	90	82	4	IPR000048
Domain	IQ	SCN1A SCN2A SCN8A IQCG	7.49e-04	93	82	4	PS50096
Domain	BROMODOMAIN_2	BRD8 BRD9 ASH1L	7.71e-04	41	82	3	PS50014
Domain	BROMO	BRD8 BRD9 ASH1L	8.28e-04	42	82	3	SM00297
Domain	Bromodomain	BRD8 BRD9 ASH1L	8.28e-04	42	82	3	IPR001487
Domain	-	BRD8 BRD9 ASH1L	8.28e-04	42	82	3	1.20.920.10
Domain	Hydrolase_3	ATP2B2 ATP2B3	8.38e-04	10	82	2	PF08282
Domain	BAH	TNRC18 ASH1L	1.02e-03	11	82	2	SM00439
Domain	BAH	TNRC18 ASH1L	1.02e-03	11	82	2	PF01426
Domain	BAH	TNRC18 ASH1L	1.02e-03	11	82	2	PS51038
Domain	BAH_dom	TNRC18 ASH1L	1.02e-03	11	82	2	IPR001025
Domain	Roc	RHOT2 RHOT1	1.44e-03	13	82	2	PF08477
Domain	MIRO-like	RHOT2 RHOT1	1.44e-03	13	82	2	IPR013684
Domain	Ion_trans_dom	CACNA1F SCN1A SCN2A SCN8A	1.60e-03	114	82	4	IPR005821
Domain	Ion_trans	CACNA1F SCN1A SCN2A SCN8A	1.60e-03	114	82	4	PF00520
Domain	EF-hand-dom_pair	CACNA1F SCN1A SCN8A RHOT2 RHOT1 NIN	1.65e-03	287	82	6	IPR011992
Domain	VWC_out	FRAS1 MUC2	3.10e-03	19	82	2	SM00215
Domain	IQ	SCN1A SCN8A IQCG	3.76e-03	71	82	3	PF00612
Domain	HAD-like_dom	ATP2B2 ATP2B3 ATP2B4	5.07e-03	79	82	3	IPR023214
Domain	-	HIP1R STAM	5.78e-03	26	82	2	1.25.40.90
Domain	ENTH_VHS	HIP1R STAM	7.16e-03	29	82	2	IPR008942
Domain	PSI	ATRN PLXNB1	8.67e-03	32	82	2	PF01437
Domain	Plexin_repeat	ATRN PLXNB1	8.67e-03	32	82	2	IPR002165
Pathway	REACTOME_CARDIAC_CONDUCTION	NPPA SCN1A SCN2A ASPH SCN8A ATP2B2 ATP2B3 ATP2B4	3.56e-08	130	55	8	M27454
Pathway	REACTOME_MUSCLE_CONTRACTION	NPPA SCN1A SCN2A ASPH SCN8A ATP2B2 ATP2B3 ATP2B4	1.10e-06	203	55	8	M5485
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2B2 ATP2B3 ATP2B4	1.21e-05	12	55	3	M27326
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2B2 ATP2B3 ATP2B4	1.98e-05	14	55	3	MM15052
Pathway	WP_RETT_SYNDROME	HIVEP2 SCN1A SCN2A SCN8A	3.55e-05	48	55	4	M39759
Pathway	REACTOME_CARDIAC_CONDUCTION	NPPA ASPH ATP2B2 ATP2B3 ATP2B4	4.92e-05	103	55	5	MM15196
Pathway	REACTOME_ION_HOMEOSTASIS	ASPH ATP2B2 ATP2B3 ATP2B4	5.67e-05	54	55	4	M27460
Pathway	REACTOME_ION_HOMEOSTASIS	ASPH ATP2B2 ATP2B3 ATP2B4	5.67e-05	54	55	4	MM15202
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2B2 ATP2B3 ATP2B4	1.54e-04	27	55	3	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2B2 ATP2B3 ATP2B4	1.72e-04	28	55	3	M924
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN8A	1.72e-04	28	55	3	M45519
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN8A	2.34e-04	31	55	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN2A SCN8A	2.57e-04	32	55	3	M27455
Pathway	REACTOME_MIRO_GTPASE_CYCLE	RHOT2 RHOT1	3.10e-04	7	55	2	MM15689
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	ATP2B2 ATP2B3 ATP2B4	3.66e-04	36	55	3	M39831
Pathway	REACTOME_MIRO_GTPASE_CYCLE	RHOT2 RHOT1	4.12e-04	8	55	2	M41837
Pathway	REACTOME_MUSCLE_CONTRACTION	NPPA ASPH ATP2B2 ATP2B3 ATP2B4	4.48e-04	165	55	5	MM15026
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1F PDGFRB ATP2B2 ATP2B3 ATP2B4	6.33e-04	178	55	5	M2890
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	AGER SCN8A MMP19	7.58e-04	46	55	3	M46450
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP2B2 ATP2B3 ATP2B4	1.28e-03	55	55	3	M971
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP2B2 ATP2B3 ATP2B4	1.42e-03	57	55	3	MM15643
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	1.36e-08	3	84	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	1.36e-08	3	84	3	28518218
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	1.36e-08	3	84	3	17928448
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	12209837
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN8A	5.43e-08	4	84	3	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN8A	5.43e-08	4	84	3	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN8A	5.43e-08	4	84	3	29578003
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	12784250
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	5.43e-08	4	84	3	21156207
Pubmed	Calcium pumps of plasma membrane and cell interior.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	15101689
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	8245032
Pubmed	Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	10577388
Pubmed	Structural organization, ion transport, and energy transduction of P-type ATPases.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	8634322
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	7989379
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	11152753
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	36130203
Pubmed	Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.	ATP2B2 ATP2B3 ATP2B4	5.43e-08	4	84	3	10434059
Pubmed	Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.	ATP2B2 ATP2B3 ATP2B4	1.35e-07	5	84	3	17938178
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN8A	2.70e-07	6	84	3	23652591
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	ATP2B2 ATP2B3 ATP2B4	2.70e-07	6	84	3	12767889
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	4.72e-07	7	84	3	25818041
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2B2 ATP2B3 ATP2B4	7.54e-07	8	84	3	10951186
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN8A	1.13e-06	9	84	3	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN8A	1.13e-06	9	84	3	15746173
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1F ATP2B2 ATP2B3 ATP2B4	2.19e-06	38	84	4	30786075
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SART1 BRD8 PTPN14 HMCN2 RSF1 BRD9 ASH1L RHOT2 RREB1 POLR1G ANKHD1 RHOT1 NIN	2.70e-06	1116	84	13	31753913
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN8A	2.94e-06	12	84	3	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN8A	3.82e-06	13	84	3	15123669
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	5.76e-06	2	84	2	29649454
Pubmed	Testosterone suppresses spermatogenesis in juvenile spermatogonial depletion (jsd ) mice.	UTP14A UTP14C	5.76e-06	2	84	2	11466222
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	5.76e-06	2	84	2	37901435
Pubmed	Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.	RHOT2 RHOT1	5.76e-06	2	84	2	19098100
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	5.76e-06	2	84	2	26410685
Pubmed	Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.	RHOT2 RHOT1	5.76e-06	2	84	2	24256248
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	5.76e-06	2	84	2	10827969
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	5.76e-06	2	84	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	5.76e-06	2	84	2	35348308
Pubmed	PTPN14 aggravates neointimal hyperplasia via boosting PDGFRβ signaling in smooth muscle cells.	PTPN14 PDGFRB	5.76e-06	2	84	2	39191789
Pubmed	Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice.	UTP14A UTP14C	5.76e-06	2	84	2	14500567
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	5.76e-06	2	84	2	15760941
Pubmed	Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice.	UTP14A UTP14C	5.76e-06	2	84	2	11415997
Pubmed	Restoration of spermatogenesis and fertility in azoospermic mutant mice by suppression and reelevation of testosterone followed by intracytoplasmic sperm injection.	UTP14A UTP14C	5.76e-06	2	84	2	11751268
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	5.76e-06	2	84	2	1317301
Pubmed	Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.	HIVEP3 HIVEP2	5.76e-06	2	84	2	20404140
Pubmed	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.	RHOT2 RHOT1	5.76e-06	2	84	2	31562315
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	5.76e-06	2	84	2	33096315
Pubmed	Potential novel markers in IBD and CRC diagnostics. Are MMP-19 and RAGE promising candidates?	AGER MMP19	5.76e-06	2	84	2	35352707
Pubmed	Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively.	ATP2B2 ATP2B3	5.76e-06	2	84	2	8187550
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	5.76e-06	2	84	2	31439038
Pubmed	Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation.	UTP14A UTP14C	5.76e-06	2	84	2	1346141
Pubmed	Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis.	RHOT2 RHOT1	5.76e-06	2	84	2	12482879
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	5.76e-06	2	84	2	17805013
Pubmed	Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.	RHOT2 RHOT1	5.76e-06	2	84	2	33132189
Pubmed	Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment.	UTP14A UTP14C	5.76e-06	2	84	2	10499552
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	5.76e-06	2	84	2	26311622
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	5.76e-06	2	84	2	33411788
Pubmed	Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.	ATP2B2 ATP2B4	5.76e-06	2	84	2	1313367
Pubmed	Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.	ATP2B3 ATP2B4	5.76e-06	2	84	2	1531651
Pubmed	Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution.	RHOT2 RHOT1	5.76e-06	2	84	2	29311115
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	5.76e-06	2	84	2	31943325
Pubmed	shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.	UTP14A UTP14C	5.76e-06	2	84	2	25790000
Pubmed	Defect in germ cells, not in supporting cells, is the cause of male infertility in the jsd mutant mouse: proliferation of spermatogonial stem cells without differentiation.	UTP14A UTP14C	5.76e-06	2	84	2	11168646
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	5.76e-06	2	84	2	15249644
Pubmed	Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.	ATP2B2 ATP2B4	5.76e-06	2	84	2	22252018
Pubmed	Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.	HIVEP3 HIVEP2	5.76e-06	2	84	2	2247438
Pubmed	Plasma membrane Ca²⁺-ATPases can shape the pattern of Ca²⁺ transients induced by store-operated Ca²⁺ entry.	ATP2B2 ATP2B4	5.76e-06	2	84	2	25690014
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	5.76e-06	2	84	2	21377452
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	5.76e-06	2	84	2	18601978
Pubmed	Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.	RHOT2 RHOT1	5.76e-06	2	84	2	30513825
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	5.76e-06	2	84	2	19465131
Pubmed	Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice.	UTP14A UTP14C	5.76e-06	2	84	2	9354954
Pubmed	The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.	RHOT2 RHOT1	5.76e-06	2	84	2	32948353
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	5.76e-06	2	84	2	37665666
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	5.76e-06	2	84	2	17881658
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	5.76e-06	2	84	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	5.76e-06	2	84	2	23735284
Pubmed	Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.	ATP2B2 ATP2B4	5.76e-06	2	84	2	16216224
Pubmed	Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.	UTP14A UTP14C	5.76e-06	2	84	2	21733828
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 FLNC FRAS1 TNRC18 HIVEP2 SCN8A HIP1R RHOT2 ANKHD1 BCL2L13 ABCC10 CD276	1.37e-05	1105	84	12	35748872
Pubmed	Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice.	UTP14A UTP14C	1.73e-05	3	84	2	3401545
Pubmed	Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.	SCN1A SCN2A	1.73e-05	3	84	2	28784306
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	1.73e-05	3	84	2	32185219
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	1.73e-05	3	84	2	22456610
Pubmed	Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.	RHOT2 RHOT1	1.73e-05	3	84	2	30856164
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A	1.73e-05	3	84	2	12610651
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	1.73e-05	3	84	2	32005694
Pubmed	The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b.	UTP14A UTP14C	1.73e-05	3	84	2	15289605
Pubmed	Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.	TACC2 STAM	1.73e-05	3	84	2	25884766
Pubmed	Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.	RHOT2 RHOT1	1.73e-05	3	84	2	26259702
Pubmed	An X-to-autosome retrogene is required for spermatogenesis in mice.	UTP14A UTP14C	1.73e-05	3	84	2	15258580
Pubmed	Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.	RHOT2 RHOT1	1.73e-05	3	84	2	30111583
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A	1.73e-05	3	84	2	23859570
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A	1.73e-05	3	84	2	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A	1.73e-05	3	84	2	17544618
Pubmed	Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.	UTP14A UTP14C	1.73e-05	3	84	2	17291484
Pubmed	Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.	SCN2A SCN8A	1.73e-05	3	84	2	16033895
Pubmed	Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.	SCN2A SCN8A	1.73e-05	3	84	2	29991598
Pubmed	Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.	UTP14A UTP14C	1.73e-05	3	84	2	30910870
Pubmed	Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.	SCN1A SCN8A	1.73e-05	3	84	2	24704313
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	3.58e-06	8	82	3	int:SCN4B
Interaction	CYP2B6 interactions	ATP2B2 ATP2B3 ATP2B4	3.58e-06	8	82	3	int:CYP2B6
Interaction	LILRB4 interactions	ATP2B2 ATP2B3 ATP2B4 CD276	4.84e-06	28	82	4	int:LILRB4
Interaction	C17orf78 interactions	ATP2B2 ATP2B3 ATP2B4	1.39e-05	12	82	3	int:C17orf78
Interaction	HSD17B6 interactions	ATP2B2 ATP2B3 ATP2B4	2.85e-05	15	82	3	int:HSD17B6
Interaction	RHOT2 interactions	BRD8 SECISBP2 TACC2 RHOT2 BCL2L13 ATP2B2 MTFR1L RHOT1	4.86e-05	321	82	8	int:RHOT2
Interaction	DHX40 interactions	ZNF462 BRD8 G3BP1 UTP14A RREB1 RBM20 NIN	6.98e-05	249	82	7	int:DHX40
Cytoband	Ensembl 112 genes in cytogenetic band chr6p24	TXNDC5 RREB1 TFAP2A	2.96e-04	70	84	3	chr6p24
Cytoband	2q24.3	SCN1A SCN2A	3.90e-04	16	84	2	2q24.3
Cytoband	10q23.2	NUTM2A NUTM2D	4.42e-04	17	84	2	10q23.2
Cytoband	5q33.1	G3BP1 PDGFRB	1.04e-03	26	84	2	5q33.1
GeneFamily	ATPases Ca2+ transporting	ATP2B2 ATP2B3 ATP2B4	1.46e-06	9	48	3	1209
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN8A	1.46e-06	9	48	3	1203
GeneFamily	Miro like atypical Rho GTPases\|EF-hand domain containing	RHOT2 RHOT1	6.90e-06	2	48	2	392
Coexpression	GSE17301_CTRL_VS_48H_IFNA2_STIM_CD8_TCELL_DN	HIVEP2 AGER BRD9 SCN8A TENM1 RHOT2 PLXNB1	3.02e-06	196	83	7	M8034
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F FRAS1 NRK SCN2A TENM1 SPAG17	1.35e-06	184	84	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F FRAS1 NRK SCN2A TENM1 SPAG17	1.35e-06	184	84	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F FRAS1 NRK SCN2A TENM1 SPAG17	1.35e-06	184	84	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNC PTPN14 KCNJ8 SCN2A ATP2B4 IPO11	1.62e-06	190	84	6	e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNC PTPN14 KCNJ8 SCN2A ATP2B4 IPO11	1.62e-06	190	84	6	f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNC PTPN14 KCNJ8 SCN2A ATP2B4 IPO11	1.62e-06	190	84	6	b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 SCN1A SCN2A SCN8A ATP2B2 ATP2B4	1.77e-06	193	84	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	droplet-Heart-HEART-1m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PTPN14 SCN1A NRK GARIN2 IPO11	1.77e-06	193	84	6	d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 SCN1A SCN2A SCN8A ATP2B2 ATP2B4	1.77e-06	193	84	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 SCN1A SCN2A SCN8A ATP2B2 ATP2B4	1.77e-06	193	84	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 NLGN3 SCN1A SCN2A HIP1R TACC2	2.12e-06	199	84	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NUTM2E FRAS1 SCN2A TACC2 TFAP2A	1.24e-05	158	84	5	7960337d87afecf2692ab65e5991f052ceddfacc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SCN2A HIP1R SPAG17 TFAP2A	1.76e-05	170	84	5	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	facs-Kidney-nan-24m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PDGFRB ANKRD1 PPIP5K1 MMP19	2.32e-05	180	84	5	f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	FLNC ANKRD1 TACC2 ATP2B4 RBM20	2.44e-05	182	84	5	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A SCN2A SCN8A ATP2B2 ATP2B3	2.57e-05	184	84	5	7d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HMCN2 AGER KCNJ8 TFAP2A	2.67e-05	91	84	4	f59908093416ca7b3ca27019d71c79acbdea18cb
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HMCN2 AGER KCNJ8 TFAP2A	2.67e-05	91	84	4	104d2ab9fe5cc404388c32fafb34e421c2e138be
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HMCN2 AGER KCNJ8 TFAP2A	2.67e-05	91	84	4	78e2e65beb15bf1e251974c72fbcfab817492772
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 SCN1A SCN2A SCN8A ATP2B4	2.71e-05	186	84	5	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMKK1 SCN2A ASPH ATP2B2 ATP2B3	2.78e-05	187	84	5	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	droplet-Lung-nan-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PTPN14 KCNJ8 ATP2B4 IPO11	2.85e-05	188	84	5	a6ed43fdd42d681c9fbb2fb368947ab7e41d8d7c
ToppCell	droplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PTPN14 KCNJ8 ATP2B4 IPO11	2.85e-05	188	84	5	54550313db78b3b5b572fa1e67092c8f6f33aab5
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FLNC AGER ANKRD1 MMP19	2.91e-05	93	84	4	af489f0dd76c3c1a84d164283149f550a7ece91c
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FLNC AGER ANKRD1 MMP19	2.91e-05	93	84	4	c1d0afcfa37c2dcbb12189b4ce56ae7c4bb7ba30
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FLNC AGER ANKRD1 MMP19	2.91e-05	93	84	4	0ea74c2820372d60d3804bf2c8bb0d03733dff98
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 PTPN14 NRK ATP2B4 IPO11	2.93e-05	189	84	5	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	FLNC ANKRD1 TACC2 ATP2B4 RBM20	2.93e-05	189	84	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 PTPN14 NRK ATP2B4 IPO11	2.93e-05	189	84	5	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	FLNC ANKRD1 TACC2 ATP2B4 RBM20	3.00e-05	190	84	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SCN2A SCN8A TENM1 ATP2B2 ATP2B3	3.00e-05	190	84	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	droplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PTPN14 NRK GARIN2 IPO11	3.08e-05	191	84	5	4bfdf44d4402a42530d30c89d94946acdda4321b
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SCN2A SCN8A TENM1 ATP2B2 ATP2B3	3.16e-05	192	84	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	NPPA FRAS1 ANKRD1 TACC2 RBM20	3.32e-05	194	84	5	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	ANKRD1 MACROD2 TACC2 ATP2B4 RBM20	3.40e-05	195	84	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGER SCN1A KCNJ8 MACROD2 TACC2	3.40e-05	195	84	5	3e24570def013d5b0b1ef1d7a5ced7dfd922590b
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FLNC PTPN14 HMCN2 PDGFRB NRK	3.48e-05	196	84	5	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NLGN3 SCN1A SCN2A HIP1R TACC2	3.48e-05	196	84	5	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NLGN3 SCN1A SCN2A HIP1R TACC2	3.48e-05	196	84	5	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	CACNA1F SCN1A ASPH PROCA1 PLXNB1	3.57e-05	197	84	5	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 SCN1A SCN2A SCN8A ATP2B2	3.65e-05	198	84	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 SCN1A SCN2A SCN8A ATP2B2	3.65e-05	198	84	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNA1F FRAS1 AGER ANKRD1 PLXNB1	3.65e-05	198	84	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 NLGN3 SCN1A HIP1R TACC2	3.74e-05	199	84	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNA1F FRAS1 AGER ANKRD1 PLXNB1	3.74e-05	199	84	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 NLGN3 SCN1A HIP1R TACC2	3.74e-05	199	84	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Inmt_(Inmt)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	8.13e-05	121	84	4	5035e071033cb76a7fc0128716755b14821e8f05
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Inmt_(Inmt)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	8.13e-05	121	84	4	c96115bd33455296378a257583b49442d00b39ca
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	AGER NRK MMP19 TFAP2A	8.67e-05	123	84	4	28be15b759c152662b29c323b1cc3f02f7830dbe
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FLNC HMCN2 MMP19 TFAP2A	9.51e-05	126	84	4	f1f24b06d301c266226d1a59dd28585f5ac68f29
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FLNC HMCN2 MMP19 TFAP2A	9.51e-05	126	84	4	fe6900eb37e4f09465a1276586c73dd38545fa2a
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_TIP\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FLNC HMCN2 MMP19 TFAP2A	9.51e-05	126	84	4	3d507f829882d043f633db2612b76936e2042445
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-6\|TCGA-Lung / Sample_Type by Project: Shred V9	PRAM1 HMCN2 SCN1A PRX	9.51e-05	126	84	4	b49b15ba1458488f98d54e87100257a12ee34076
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FLNC HMCN2 MMP19 TFAP2A	9.51e-05	126	84	4	1ac4cc747e466bc79e33b97608b19ad29a7a6a41
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FLNC HMCN2 MMP19 TFAP2A	9.51e-05	126	84	4	2de551d7a8765afec1da8852727c79fec90f45f8
ToppCell	Control-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1F ANKRD1 AP3B2 RBM20	9.81e-05	127	84	4	556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	1.04e-04	129	84	4	856255fbfc7f95642000cfd7704141b2388f7c5c
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	1.21e-04	134	84	4	b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	HMCN2 PDGFRB KCNJ8 TFAP2A	1.24e-04	135	84	4	e908aacb72a8c340f06cf5b4a6b70c2faac4d027
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	NLGN3 HMCN2 SCN2A IQCG	1.31e-04	137	84	4	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 SCN1A TENM1 ATP2B3	1.63e-04	145	84	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	ANKRD1 MACROD2 TACC2 SPAG17	1.91e-04	151	84	4	8216462e723fec2797387929dde095370947e10a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NLGN3 SCN1A SCN2A TACC2	2.11e-04	155	84	4	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 PTPN14 MACROD2 PLXNB1	2.22e-04	157	84	4	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	2.33e-04	159	84	4	92049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNC PTPN14 SCN1A IPO11	2.44e-04	161	84	4	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNC PTPN14 SCN1A IPO11	2.44e-04	161	84	4	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNC PTPN14 SCN1A IPO11	2.44e-04	161	84	4	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNC PTPN14 SCN1A IPO11	2.50e-04	162	84	4	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIVEP3 NRK SCN2A MACROD2	2.50e-04	162	84	4	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	2.68e-04	165	84	4	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	2.68e-04	165	84	4	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	wk_20-22-Hematologic-Myeloid-GMP\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PRAM1 PROCA1 URB2 RREB1	2.74e-04	166	84	4	d96e88e73a40205f32cebd7e54ca1ff09ee1e7e8
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FLNC NRK MMP19 TFAP2A	2.87e-04	168	84	4	26aa96b2b547d11941cb803995ea3d302ee0518c
ToppCell	P28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NLGN3 TNRC18 AGER POLR1G	2.87e-04	168	84	4	8c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCell	367C-Epithelial_cells-Epithelial-B_(AT2)\|367C / Donor, Lineage, Cell class and subclass (all cells)	AGER SCN1A MACROD2 TACC2	2.87e-04	168	84	4	e20e1936573fdde78426d7a4eb45c458d5c4dbb4
ToppCell	367C-Epithelial_cells-Epithelial-B_(AT2)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	AGER SCN1A MACROD2 TACC2	2.87e-04	168	84	4	16b517e3159ad6e6d25fd48f7d5f46e77b2b318d
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 ATP2B3 TFAP2A PRX	3.14e-04	172	84	4	c0bda7153e02bee7d0326138cc684151c404c2a1
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB AGER KCNJ8 PLXNB1	3.21e-04	173	84	4	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1F FRAS1 TXNDC5 SCN8A	3.21e-04	173	84	4	b335ca2a247156eba821943b2b9fc9922230b409
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB AGER KCNJ8 PLXNB1	3.21e-04	173	84	4	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	Pericytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	NLGN3 FLNC NPPA PDGFRB	3.35e-04	175	84	4	ddf721023a7afc8085c5de17aa254a6575444c0f
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLNC ANKRD1 ATP2B4 RBM20	3.42e-04	176	84	4	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLGN3 FLNC KCNJ8 NRK	3.50e-04	177	84	4	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SCN2A TENM1 TFAP2A PLXNB1	3.50e-04	177	84	4	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 PTPN14 MACROD2 PLXNB1	3.57e-04	178	84	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPPA NRK ANKRD1 PROCA1	3.57e-04	178	84	4	5fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 PTPN14 AGER ANKRD1	3.65e-04	179	84	4	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 NRK SCN2A TFAP2A	3.65e-04	179	84	4	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	FRAS1 PTPN14 MACROD2 TFAP2A	3.65e-04	179	84	4	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	SCN1A ASPH MACROD2 TACC2	3.72e-04	180	84	4	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PTPN14 AGER ANKRD1	3.72e-04	180	84	4	6327c938a4f99df9fee714e44f15ea4a4a63ae15
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SCN2A HIP1R TFAP2A	3.72e-04	180	84	4	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PDGFRB ANKRD1 MMP19	3.80e-04	181	84	4	c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC PDGFRB ANKRD1 MMP19	3.80e-04	181	84	4	0ec9621a078d004bbd25a587757d24b5cf162959
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 SCN2A MMP19 CD276	3.80e-04	181	84	4	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NUTM2E SCN2A TACC2 TFAP2A	3.80e-04	181	84	4	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SCN2A STAM TFAP2A	3.80e-04	181	84	4	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMCN2 SCN2A NUTM2D ATP2B4	3.80e-04	181	84	4	beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	FRAS1 PTPN14 MACROD2 TFAP2A	3.96e-04	183	84	4	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
Drug	1sqc	ATP2B2 ATP2B3 ATP2B4	5.50e-06	10	83	3	CID000444279
Drug	2,5-dimethylquinone	ATP2B2 ATP2B3 ATP2B4	7.55e-06	11	83	3	CID000008718
Drug	1vyq	ATP2B2 ATP2B3 ATP2B4	1.00e-05	12	83	3	CID004369390
Drug	Ro 46861	ATP2B2 ATP2B3 ATP2B4	1.00e-05	12	83	3	CID000003128
Drug	8-hydroxycoumarin	ATP2B2 ATP2B3 ATP2B4	1.30e-05	13	83	3	CID000122783
Drug	p-hydroxyhippuric acid	ATP2B2 ATP2B3 ATP2B4	1.65e-05	14	83	3	CID000151012
Drug	AC1L88YH	ATP2B2 ATP2B3 ATP2B4	3.06e-05	17	83	3	CID000374551
Disease	Neurodevelopmental Disorders	HIVEP3 PPM1D SCN1A SCN2A SCN8A ASH1L PLXNB1	7.06e-09	93	81	7	C1535926
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B2 ATP2B3 ATP2B4	3.96e-07	6	81	3	DOID:0050429 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN8A	2.36e-06	10	81	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN8A	2.36e-06	10	81	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN8A	4.31e-06	12	81	3	DOID:0060170 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	2.23e-05	3	81	2	cv:C5575231
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN3 PDGFRB SCN1A SCN2A ASH1L	6.35e-05	152	81	5	DOID:0060041 (implicated_via_orthology)
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	7.40e-05	5	81	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.11e-04	6	81	2	C0334488
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	1.11e-04	6	81	2	C0220669
Disease	childhood onset asthma, age at onset, environmental tobacco smoke exposure measurement	MACROD2 NIN	1.11e-04	6	81	2	EFO_0004847, EFO_0008361, MONDO_0005405
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	1.55e-04	7	81	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	1.55e-04	7	81	2	C0751057
Disease	infection	RSF1 MACROD2	2.65e-04	9	81	2	EFO_0000544
Disease	Febrile Convulsions	SCN1A SCN2A	2.65e-04	9	81	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	2.65e-04	9	81	2	C3502809
Disease	uveitis	TNRC18 POLR1G	2.65e-04	9	81	2	EFO_1001231
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP3 HIVEP2 AGER	5.24e-04	57	81	3	DOID:10652 (implicated_via_orthology)
Disease	juvenile polyposis syndrome (implicated_via_orthology)	HIVEP3 HIVEP2	5.69e-04	13	81	2	DOID:0050787 (implicated_via_orthology)
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	5.69e-04	13	81	2	C0751122
Disease	sporadic amyotrophic lateral sclerosis	MACROD2 ATP2B2 TFAP2A ATP2B4	6.09e-04	140	81	4	EFO_0001357
Disease	bipolar I disorder	MACROD2 ANKHD1 ATP2B2 ATP2B4	6.25e-04	141	81	4	EFO_0009963
Disease	MMR-related febrile seizures	SCN1A SCN2A	7.64e-04	15	81	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	8.71e-04	16	81	2	C0393706
Disease	iritis	TNRC18 POLR1G	9.85e-04	17	81	2	EFO_1000997
Disease	Atrial Fibrillation	ZNF462 KCNJ8 HIP1R RBM20	1.00e-03	160	81	4	C0004238
Disease	bipolar disorder	HIVEP2 SCN2A MACROD2 ANKHD1 ATP2B2 ATP2B4 CD276	1.05e-03	577	81	7	MONDO_0004985
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	1.11e-03	18	81	2	HP_0002373
Disease	chronic kidney disease (is_marker_for)	NPPA AGER	1.37e-03	20	81	2	DOID:784 (is_marker_for)
Disease	Intellectual Disability	ZNF462 HIVEP2 PDGFRB SCN1A SCN8A ASH1L	1.46e-03	447	81	6	C3714756
Disease	Epilepsy, Cryptogenic	SCN1A SCN2A SCN8A	1.51e-03	82	81	3	C0086237
Disease	Awakening Epilepsy	SCN1A SCN2A SCN8A	1.51e-03	82	81	3	C0751111
Disease	Aura	SCN1A SCN2A SCN8A	1.51e-03	82	81	3	C0236018
Disease	Infiltrating duct carcinoma of female breast	PDGFRB NRK	1.51e-03	21	81	2	C3165106
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A	1.66e-03	22	81	2	DOID:2030 (implicated_via_orthology)
Disease	sciatic neuropathy (biomarker_via_orthology)	NLGN3 PDGFRB KCNJ8	2.59e-03	99	81	3	DOID:11446 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ADPEIPVQVTQDIEP	URB2	1211	Q14146
EPTEVEEVVPALEPT	BCL2L13	391	Q9BXK5
EVVPPQVLSEPNEEA	NPPA	56	P01160
EEQEPPILQPEIEIP	ASH1L	861	Q9NR48
VPLVEVQDPVEVPSG	CCDC116	106	Q8IYX3
EPAEPEPVISGAEIV	BRD8	511	Q9H0E9
NEDTAVEEPVPEVVP	BRD9	246	Q9H8M2
VEEPVPEVVPVQVET	BRD9	251	Q9H8M2
VVKEPEPEIITEPVD	ANKRD1	106	Q15327
IEEVPHVEDPGINIP	TFAP2A	156	P05549
TGAVEEPAEVPVPEQ	ACSF3	176	Q4G176
AVEVQVPEDPVVALV	CD276	246	Q5ZPR3
ITEVTAPPEDNPVED	ASPH	276	Q12797
CVVGIEDPVRPEVPE	ATP2B2	701	Q01814
VVGIEDPVRPEVPEA	ATP2B3	676	Q16720
AVVGIEDPVRPEVPD	ATP2B4	666	P23634
EEAPDPSVRNVEVPE	AP3B2	646	Q13367
TDIEIIPEIPETLEP	IQCG	41	Q9H095
EPVPLEEVQLVVEPE	AGER	231	Q15109
IVEPDIPELEEIVPI	RBM20	921	Q5T481
LDEVIPPPDEEEVTV	CACNA1F	1566	O60840
QEPLLPEDQEPEVAE	ABCC10	201	Q5T3U5
DDNPQDVVIEIIDPP	FRAS1	1246	Q86XX4
PEGEVVPIHQLDIPV	KCNJ8	236	Q15842
EDIFPVTPPELEETI	LRIF1	726	Q5T3J3
KEPVPVPVQEIEIDS	NUDCD3	106	Q8IVD9
VPPVLEPVEFQNDVV	HMCN2	3411	Q8NDA2
KNEPVVFPEEPEISE	CAMKK1	366	Q8N5S9
IVPERDGNETVPEVV	ATRN	206	O75882
EEPKVTEDEEPPTEQ	IPO11	901	Q9UI26
VVVEARVECEPPPDT	PLXNB1	961	O43157
EEVPPRAEEITIPAD	RHOT1	31	Q8IXI2
EEEETELPTVPPVPT	MMP19	266	Q99542
QPDVVCEDPEEEVAP	MUC2	201	Q02817
VPQVIAPEEIVDPNV	FLNC	231	Q14315
EETEVEVPELPSVPL	MTFR1L	191	Q9H019
QIVVEPEPTAEEKPS	PPM1D	26	O15297
PVIDGDVIPDDPEIL	NLGN3	376	Q9NZ94
PVVVIPEEAPEDEEP	HIP1R	301	O75146
PPEPTDRAVIEQEVR	CC2D2A	621	Q9P2K1
EPEQEPVSEIQEEKP	G3BP1	201	Q13283
PVSEIQEEKPEPVLE	G3BP1	206	Q13283
PEVPEIQECPIAQES	GEMIN7	36	Q9H840
QVPEPEGQLEEPTLE	FAM166B	146	A8MTA8
IEPAQAVDEVEPLPE	DCTN4	216	Q9UJW0
IIPPQEPDFSEDQEE	RSF1	981	Q96T23
EEEEEEESKPPIPTQ	PROCA1	176	Q8NCQ7
ATIVDDVEVAPVPEP	NEURL4	681	Q96JN8
EPEPQLELQVEPEPE	PDGFRB	1071	P09619
DAVIVEQPEVIPLTE	MACROD2	361	A1Z1Q3
TKVPEEIPPEVVQEY	NUTM2A	506	Q8IVF1
TKVPEEIPPEVVQEY	NUTM2B	506	A6NNL0
VPEEIPPEVVQEYVD	NUTM2D	436	Q5VT03
TKVPEEIPPEVVQEY	NUTM2E	506	B1AL46
VPEEIPPEVVQEYVD	NUTM2F	386	A1L443
VPEEIPPEVVQEYVD	NUTM2G	371	Q5VZR2
FVEVPEESPKQPSEV	NRK	1171	Q7Z2Y5
VTDLPENEVPEVPDV	GARIN2	246	Q8N9W8
PEVTVIEPLDEEARP	NIN	121	Q8N4C6
EEVPPRAEEITIPAD	RHOT2	31	Q8IXI1
QDRQPEDIPQVPDEI	PRAM1	491	Q96QH2
EEEEEEAPESVPQIP	PTPN14	711	Q15678
TVEPETEVVGPELPD	POLR1G	396	O15446
TVQEPPRIEDAEEFP	SECISBP2	396	Q96T21
IVPELQVVQEEIPIP	TENM1	1006	Q9UKZ4
EVEPEPVLQETLDVP	SPAG17	1206	Q6Q759
APVEEQPVVEPEETL	SCN1A	1161	P35498
QPVVEPEETLEPEAC	SCN1A	1166	P35498
EDVEQEVPIEPPSAT	ANKHD1	1496	Q8IWZ3
EAKEEPVEVPVAVPV	TNRC18	1256	O15417
TVPQVQREEPAPEEA	UTP14C	481	Q5TAP6
QEEKPPETPAEVVES	RREB1	1441	Q92766
VRSPEVVVDDEVPGP	SPDYE4	21	A6NLX3
VEIVTPQLPAVEIEE	PRX	901	Q9BXM0
LPLVEEEEAVSEPEP	RNF10	446	Q8N5U6
QPEVEPEESLEPEAC	SCN2A	1156	Q99250
PNIQVPEILVTEEPD	HIVEP3	851	Q5T1R4
PEILVTEEPDRPDTE	HIVEP3	856	Q5T1R4
PEVEEVPVEQPEEYL	SCN8A	1141	Q9UQD0
DDVQVETIEPEPEPA	STAM	286	Q92783
ETPPVKETQQEPDEE	TACC2	2146	O95359
QVQREEPAPEEEEPL	UTP14A	486	Q9BVJ6
RVSEVEEEKEPVPQP	SART1	446	O43290
QLQPPPLEPEEEEEV	ZNF853	306	P0CG23
EEEPTEPIIEVPTSF	ZNF462	741	Q96JM2
QTLNEEPVTPEPEVE	TXNDC5	166	Q8NBS9
VPVTDTEVETVEPPP	ZNF800	181	Q2TB10
TEVETVEPPPVEIVT	ZNF800	186	Q2TB10
VEPPPVEIVTDEVAP	ZNF800	191	Q2TB10
IQVPEIRVTEEPDKP	HIVEP2	886	P31629
EDEVPPEPQIIVGIC	PPIP5K1	46	Q6PFW1
VEVGSPAEEIPEEVI	PPIP5K1	1366	Q6PFW1