Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	ANXA5 PKD1L3 ITPR1 ITPR3 TRPV4 TRPM8 CNGA3	8.95e-06	151	97	7	GO:0015085
GeneOntologyMolecularFunction	cytoskeletal protein binding	ANK2 MYO1D CENPE MYO9B GMFG RABGAP1 CLSTN1 CCDC61 TULP1 MYO5C LLGL2 EGFR SNX6 TRPV4 MARK2 CORO7 CNGA3	2.00e-05	1099	97	17	GO:0008092
GeneOntologyMolecularFunction	calcium channel activity	PKD1L3 ITPR1 ITPR3 TRPV4 TRPM8 CNGA3	3.95e-05	129	97	6	GO:0005262
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR3	6.98e-05	3	97	2	GO:0005220
GeneOntologyMolecularFunction	enzyme activator activity	ERCC6 MYO9B ITSN1 SIPA1L3 GMFG CASP1 RABGAP1 DDOST TBC1D8 LLGL2 EGFR MARK2	7.95e-05	656	97	12	GO:0008047
GeneOntologyMolecularFunction	adenylyltransferase activity	OAS1 PAPSS2 PAPOLG	4.53e-04	31	97	3	GO:0070566
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	ITPR1 ITPR3 TRPM8	4.53e-04	31	97	3	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	ITPR1 ITPR3 CNGA3	5.45e-04	33	97	3	GO:0005217
GeneOntologyMolecularFunction	microfilament motor activity	MYO1D MYO9B MYO5C	8.29e-04	38	97	3	GO:0000146
GeneOntologyMolecularFunction	actin filament binding	MYO1D MYO9B TULP1 MYO5C EGFR TRPV4	8.44e-04	227	97	6	GO:0051015
GeneOntologyMolecularFunction	enzyme regulator activity	ERCC6 MYO9B ANXA5 ITSN1 SIPA1L3 GMFG CASP1 OAS1 RABGAP1 ARHGEF17 DDOST TBC1D8 LLGL2 EGFR MARK2 SOS2	1.27e-03	1418	97	16	GO:0030234
GeneOntologyMolecularFunction	alcohol binding	GRAMD1A ITPR1 ITPR3 GRAMD1B	1.55e-03	102	97	4	GO:0043178
GeneOntologyCellularComponent	actin cytoskeleton	MYO1D NCKAP1 MYO9B ITSN1 SIPA1L3 DDR2 GMFG CDC42BPB MYO5C LLGL2 TRPV4 MARK2	1.30e-05	576	96	12	GO:0015629
GeneOntologyCellularComponent	mitotic cohesin complex	STAG1 STAG2	4.32e-04	7	96	2	GO:0030892
GeneOntologyCellularComponent	anchoring junction	ANK2 NCKAP1 ANXA5 SIPA1L3 DDR2 CDH19 AQP4 CDC42BPB FAT2 LLGL2 EGFR TRPV4 RPL8	5.13e-04	976	96	13	GO:0070161
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR3	7.36e-04	9	96	2	GO:0031095
GeneOntologyCellularComponent	postsynapse	RPL27A ANK2 SYN3 NCKAP1 MYO9B ITSN1 CLSTN1 HNRNPD ITPR1 GRID2IP SNX6 MARK2 RPL8	7.60e-04	1018	96	13	GO:0098794
GeneOntologyCellularComponent	cohesin complex	STAG1 STAG2	1.12e-03	11	96	2	GO:0008278
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR3	1.12e-03	11	96	2	GO:0031094
GeneOntologyCellularComponent	smooth endoplasmic reticulum	MYO1D ITPR1 HSD3B2	1.23e-03	46	96	3	GO:0005790
GeneOntologyCellularComponent	smooth endoplasmic reticulum membrane	ITPR1 HSD3B2	1.34e-03	12	96	2	GO:0030868
GeneOntologyCellularComponent	endoplasmic reticulum-plasma membrane contact site	GRAMD1A GRAMD1B	1.58e-03	13	96	2	GO:0140268
GeneOntologyCellularComponent	cell-cell junction	ANK2 ANXA5 SIPA1L3 CDH19 AQP4 CDC42BPB FAT2 LLGL2 TRPV4	1.59e-03	591	96	9	GO:0005911
Domain	-	BZW2 NOM1 BZW1	5.73e-05	15	96	3	1.25.40.180
Domain	MIF4-like	BZW2 NOM1 BZW1	5.73e-05	15	96	3	IPR016021
Domain	GRAM	GRAMD1A TBC1D8 GRAMD1B	7.02e-05	16	96	3	SM00568
Domain	DUF4782	GRAMD1A GRAMD1B	7.82e-05	3	96	2	IPR031968
Domain	InsP3_rcpt-bd	ITPR1 ITPR3	7.82e-05	3	96	2	IPR000493
Domain	VAST	GRAMD1A GRAMD1B	7.82e-05	3	96	2	PS51778
Domain	DUF4782	GRAMD1A GRAMD1B	7.82e-05	3	96	2	PF16016
Domain	SCD	STAG1 STAG2	1.56e-04	4	96	2	PS51425
Domain	SCD	STAG1 STAG2	1.56e-04	4	96	2	IPR020839
Domain	STAG	STAG1 STAG2	1.56e-04	4	96	2	PF08514
Domain	STAG	STAG1 STAG2	1.56e-04	4	96	2	IPR013721
Domain	GRAM	GRAMD1A TBC1D8 GRAMD1B	1.89e-04	22	96	3	PF02893
Domain	GRAM	GRAMD1A TBC1D8 GRAMD1B	1.89e-04	22	96	3	IPR004182
Domain	Ion_trans_dom	ITPR1 ITPR3 TRPV4 TRPM8 CNGA3	3.05e-04	114	96	5	IPR005821
Domain	Ion_trans	ITPR1 ITPR3 TRPV4 TRPM8 CNGA3	3.05e-04	114	96	5	PF00520
Domain	RIH_assoc-dom	ITPR1 ITPR3	3.87e-04	6	96	2	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR3	3.87e-04	6	96	2	PF08709
Domain	RIH_assoc	ITPR1 ITPR3	3.87e-04	6	96	2	PF08454
Domain	RIH_dom	ITPR1 ITPR3	3.87e-04	6	96	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR3	3.87e-04	6	96	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR3	3.87e-04	6	96	2	IPR015925
Domain	-	ITPR1 ITPR3	3.87e-04	6	96	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR3	3.87e-04	6	96	2	PF01365
Domain	eIF5C	BZW2 BZW1	5.40e-04	7	96	2	SM00515
Domain	Carb_sulfotransferase-rel	CHST10 CHST11	5.40e-04	7	96	2	IPR018011
Domain	W2	BZW2 BZW1	5.40e-04	7	96	2	PF02020
Domain	W2	BZW2 BZW1	5.40e-04	7	96	2	PS51363
Domain	W2_domain	BZW2 BZW1	5.40e-04	7	96	2	IPR003307
Domain	Myosin_head_motor_dom	MYO1D MYO9B MYO5C	9.74e-04	38	96	3	IPR001609
Domain	MYOSIN_MOTOR	MYO1D MYO9B MYO5C	9.74e-04	38	96	3	PS51456
Domain	Myosin_head	MYO1D MYO9B MYO5C	9.74e-04	38	96	3	PF00063
Domain	MYSc	MYO1D MYO9B MYO5C	9.74e-04	38	96	3	SM00242
Domain	MIR	ITPR1 ITPR3	1.15e-03	10	96	2	PF02815
Domain	MIR_motif	ITPR1 ITPR3	1.15e-03	10	96	2	IPR016093
Domain	MIR	ITPR1 ITPR3	1.15e-03	10	96	2	PS50919
Domain	MIR	ITPR1 ITPR3	1.15e-03	10	96	2	SM00472
Domain	NTP_transf_2	OAS1 PAPOLG	1.40e-03	11	96	2	PF01909
Domain	Polymerase_NTP_transf_dom	OAS1 PAPOLG	1.40e-03	11	96	2	IPR002934
Domain	Sulfotransfer_2	CHST10 CHST11	1.67e-03	12	96	2	PF03567
Domain	Sulfotransferase	CHST10 CHST11	1.67e-03	12	96	2	IPR005331
Domain	ARM-type_fold	STAG1 BZW2 KPNA6 ITPR1 NOM1 BZW1 STAG2	1.83e-03	339	96	7	IPR016024
Domain	POU	POU6F2 POU6F1	2.99e-03	16	96	2	SM00352
Domain	POU_dom	POU6F2 POU6F1	2.99e-03	16	96	2	IPR000327
Domain	Pou	POU6F2 POU6F1	2.99e-03	16	96	2	PF00157
Domain	POU_1	POU6F2 POU6F1	2.99e-03	16	96	2	PS00035
Domain	POU_2	POU6F2 POU6F1	2.99e-03	16	96	2	PS00465
Domain	POU_3	POU6F2 POU6F1	2.99e-03	16	96	2	PS51179
Domain	POU	POU6F2 POU6F1	3.38e-03	17	96	2	IPR013847
Domain	DH_1	ITSN1 ARHGEF17 SOS2	4.18e-03	63	96	3	PS00741
Domain	RhoGEF	ITSN1 ARHGEF17 SOS2	5.18e-03	68	96	3	SM00325
Domain	RhoGEF	ITSN1 ARHGEF17 SOS2	5.62e-03	70	96	3	PF00621
Domain	DH_2	ITSN1 ARHGEF17 SOS2	5.62e-03	70	96	3	PS50010
Domain	IQ	MYO1D MYO9B MYO5C	5.84e-03	71	96	3	PF00612
Domain	-	ITSN1 ARHGEF17 SOS2	5.84e-03	71	96	3	1.20.900.10
Domain	DH-domain	ITSN1 ARHGEF17 SOS2	5.84e-03	71	96	3	IPR000219
Pathway	KEGG_GAP_JUNCTION	ITPR1 ITPR3 GUCY1A2 EGFR MAP3K2 SOS2	5.40e-06	90	70	6	M4013
Pubmed	Defining the membrane proteome of NK cells.	RPL27A CENPE ERAP1 BZW2 MYO9B ANXA5 KPNA6 CHST11 DDOST ALG2 ITPR1 ITPR3 PAPOLG GRAMD1B BZW1 CORO7 STAG2 RPL8	3.55e-09	1168	97	18	19946888
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RPL27A ANK2 SYN3 MYO1D NCKAP1 ITSN1 SIPA1L3 ARHGEF17 AQP4 CDC42BPB HNRNPD ALG2 GRAMD1B GUCY1A2 MARK2 CORO7 HSPA4 RPL8	7.87e-08	1431	97	18	37142655
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RPL27A ANK2 NCKAP1 BZW2 ZC3H18 HNRNPD DDOST TBC1D8 EGFR BZW1 MARK2 HSPA4 RPL8	8.98e-08	708	97	13	39231216
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	RPL27A MYO1D NCKAP1 BZW2 ANXA5 CDC42BPB HNRNPD DDOST EGFR HSPA4 RPL8	6.88e-07	580	97	11	35676659
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ANK2 USP11 ITSN1 GRAMD1A PLXNB2 CDC42BPB CCDC61 DDOST ITPR1 ITPR3 TBC1D8 GRAMD1B EGFR SNX6 MARK2 HSPA4 RPL8	7.19e-07	1487	97	17	33957083
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MYO1D CENPE MYO9B USP11 ITSN1 KPNA6 ZC3H18 RABGAP1 PAPOLG TBC1D8 SMG7	7.87e-07	588	97	11	38580884
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RPL27A MYO1D BZW2 SIPA1L3 GRAMD1A KPNA6 CDC42BPB CCDC61 DDOST ITPR1 ITPR3 SMG7 EGFR SNX6	1.29e-06	1049	97	14	27880917
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	HSPE1 RPL27A UFSP2 MYO1D BZW2 ZC3H18 PLXNB2 DDOST ITPR1 ITPR3	1.50e-06	503	97	10	36217030
Pubmed	MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.	EGFR MAP3K2 SOS2	1.75e-06	9	97	3	19289468
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	HSPE1 RPL27A NCKAP1 BZW2 USP11 KPNA6 RABGAP1 GMPR2 PAPSS2 HNRNPD SNX6 NANS BZW1 HERC4 HSPA4 RPL8	2.62e-06	1455	97	16	22863883
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HSPE1 RPL27A HIGD2A MYO1D CENPE USP11 GRAMD1A RABGAP1 PLXNB2 HNRNPD DDOST ITPR1 ITPR3 SNX6 NOM1 MARK2	3.74e-06	1496	97	16	32877691
Pubmed	USP13 interacts with cohesin and regulates its ubiquitination in human cells.	STAG1 HSPA4 STAG2	4.54e-06	12	97	3	33334891
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RPL27A MYO1D MYO9B ANXA5 PLXNB2 HNRNPD DDOST MYO5C ITPR3 MARK2 HSPA4 STAG2 RPL8	5.49e-06	1024	97	13	24711643
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	HSPE1 RPL27A ANXA5 KPNA6 HNRNPD DDOST SNX6 HSPA4 STAG2	6.17e-06	463	97	9	34901782
Pubmed	AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4.	AQP4 TRPV4	7.70e-06	2	97	2	38735619
Pubmed	STAG Mutations in Cancer.	STAG1 STAG2	7.70e-06	2	97	2	31421907
Pubmed	Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.	STAG1 STAG2	7.70e-06	2	97	2	32778134
Pubmed	The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.	ITPR1 ITPR3	7.70e-06	2	97	2	15890645
Pubmed	Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae.	STAG1 STAG2	7.70e-06	2	97	2	22715410
Pubmed	Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.	STAG1 STAG2	7.70e-06	2	97	2	28430577
Pubmed	The absence of AQP4/TRPV4 complex substantially reduces acute cytotoxic edema following ischemic injury.	AQP4 TRPV4	7.70e-06	2	97	2	36568889
Pubmed	Immunohistochemical Expression of Caspase1 and Epidermal Growth Factor Receptor in Invasive Breast Carcinoma and Their Biological and Prognostic Associations.	CASP1 EGFR	7.70e-06	2	97	2	39068588
Pubmed	The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea.	TRPV4 TRPM8	7.70e-06	2	97	2	36517318
Pubmed	Cholinergic augmentation of insulin release requires ankyrin-B.	ANK2 ITPR1	7.70e-06	2	97	2	20234002
Pubmed	Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.	ANK2 ITPR1	7.70e-06	2	97	2	14722080
Pubmed	TRPV4-AQP4 interactions 'turbocharge' astroglial sensitivity to small osmotic gradients.	AQP4 TRPV4	7.70e-06	2	97	2	26760501
Pubmed	New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D.	MYO1D EGFR	7.70e-06	2	97	2	34459138
Pubmed	An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes.	AQP4 TRPV4	7.70e-06	2	97	2	21262839
Pubmed	Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism.	AQP4 TRPV4	7.70e-06	2	97	2	28925524
Pubmed	Evaluation of AQP4/TRPV4 Channel Co-expression, Microvessel Density, and its Association with Peritumoral Brain Edema in Intracranial Meningiomas.	AQP4 TRPV4	7.70e-06	2	97	2	33538957
Pubmed	Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.	BZW2 BZW1	7.70e-06	2	97	2	36333315
Pubmed	Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.	STAG1 STAG2	7.70e-06	2	97	2	24324008
Pubmed	Granule neuron precursor cell proliferation is regulated by NFIX and intersectin 1 during postnatal cerebellar development.	ITSN1 NFIX	7.70e-06	2	97	2	30511336
Pubmed	The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins.	AQP4 TRPV4	7.70e-06	2	97	2	26413835
Pubmed	Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.	ITPR1 ITPR3	7.70e-06	2	97	2	7559486
Pubmed	Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.	ITPR1 ITPR3	7.70e-06	2	97	2	20843799
Pubmed	GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature.	EGFR TRPV4	7.70e-06	2	97	2	25572823
Pubmed	TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia.	AQP4 TRPV4	7.70e-06	2	97	2	26424896
Pubmed	STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.	STAG1 STAG2	7.70e-06	2	97	2	34648034
Pubmed	Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.	ITPR1 ITPR3	7.70e-06	2	97	2	8663526
Pubmed	Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.	STAG1 STAG2	7.70e-06	2	97	2	29649003
Pubmed	Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.	STAG1 STAG2	7.70e-06	2	97	2	27341316
Pubmed	Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor.	ANK2 ITPR3	7.70e-06	2	97	2	18275062
Pubmed	Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.	STAG1 STAG2	7.70e-06	2	97	2	28691904
Pubmed	Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.	ITPR1 ITPR3	7.70e-06	2	97	2	1374893
Pubmed	Proteolytic cleavage of epidermal growth factor receptor by caspases.	CASP1 EGFR	7.70e-06	2	97	2	11226410
Pubmed	Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.	STAG1 STAG2	7.70e-06	2	97	2	22415365
Pubmed	Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.	BZW2 BZW1	7.70e-06	2	97	2	29470543
Pubmed	Ankyrin B modulates the function of Na,K-ATPase/inositol 1,4,5-trisphosphate receptor signaling microdomain.	ANK2 ITPR1	7.70e-06	2	97	2	18303017
Pubmed	Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.	STAG1 STAG2	7.70e-06	2	97	2	19822671
Pubmed	Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.	ITPR1 ITPR3	7.70e-06	2	97	2	20813840
Pubmed	STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.	STAG1 STAG2	7.70e-06	2	97	2	32467316
Pubmed	Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.	STAG1 STAG2	7.70e-06	2	97	2	32294612
Pubmed	Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.	STAG1 STAG2	7.70e-06	2	97	2	31495782
Pubmed	Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis.	USP11 EGFR	7.70e-06	2	97	2	36581018
Pubmed	Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.	GRAMD1A GRAMD1B	7.70e-06	2	97	2	32719109
Pubmed	Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.	ITPR1 ITPR3	7.70e-06	2	97	2	14707143
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NCKAP1 BZW2 GRAMD1A KPNA6 CLSTN1 PLXNB2 DDOST ITPR3 BZW1 CORO7 HSPA4 STAG2	1.25e-05	942	97	12	31073040
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	HSPE1 MYO1D NCKAP1 BZW2 USP11 KPNA6 PKD1L3 PAPSS2 CDC42BPB DDOST NOM1 BZW1 MARK2 MAP3K2	1.31e-05	1284	97	14	17353931
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HSPE1 NCKAP1 ERAP1 KPNA6 ARHGEF17 PLXNB2 CDC42BPB DDOST EGFR SNX6 CDYL BZW1 HERC4 HSPA4	1.46e-05	1297	97	14	33545068
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	HSPE1 RPL27A NCKAP1 ANXA5 HNRNPD DDOST NOM1 HSPA4 RPL8 MAP3K2 SOS2	1.52e-05	803	97	11	36517590
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	HSPE1 BZW2 ANXA5 RABGAP1 MARK2 HSPA4 STAG2	1.69e-05	288	97	7	23383273
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	HSPE1 ANK2 MYO1D ANXA5 KPNA6 ITPR3 EGFR	1.69e-05	288	97	7	38496616
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	HSPE1 GAD2 RPL27A ANK2 SYN3 NCKAP1 GRAMD1A RABGAP1 AQP4 CDC42BPB ITPR1 GRAMD1B RPL8	1.70e-05	1139	97	13	36417873
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO9B CDC42BPB MYO5C ITPR3 EGFR MAGEC1	2.27e-05	202	97	6	33005030
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR3	2.31e-05	3	97	2	10874040
Pubmed	Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.	ANK2 ITPR1	2.31e-05	3	97	2	26168218
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR3	2.31e-05	3	97	2	20395455
Pubmed	Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.	ITSN1 EGFR	2.31e-05	3	97	2	16914641
Pubmed	Regulating ankyrin dynamics: Roles of sigma-1 receptors.	ANK2 ITPR3	2.31e-05	3	97	2	11149946
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR3	2.31e-05	3	97	2	17437169
Pubmed	Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.	BZW2 BZW1	2.31e-05	3	97	2	34260931
Pubmed	A yeast three-hybrid method to clone ternary protein complex components.	EGFR SOS2	2.31e-05	3	97	2	8923966
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR3	2.31e-05	3	97	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR3	2.31e-05	3	97	2	36350267
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR3	2.31e-05	3	97	2	11413485
Pubmed	An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.	EGFR SNX6	2.31e-05	3	97	2	18523162
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	2.31e-05	3	97	2	26009177
Pubmed	Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.	STAG1 STAG2	2.31e-05	3	97	2	23874961
Pubmed	Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.	TRPV4 TRPM8	2.31e-05	3	97	2	29175331
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR3	2.31e-05	3	97	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR3	2.31e-05	3	97	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR3	2.31e-05	3	97	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR3	2.31e-05	3	97	2	24904548
Pubmed	Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.	ITPR1 ITPR3	2.31e-05	3	97	2	18250332
Pubmed	Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.	TRPV4 TRPM8	2.31e-05	3	97	2	26207981
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR3	2.31e-05	3	97	2	9858485
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR3	2.31e-05	3	97	2	9808793
Pubmed	TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model.	AQP4 TRPV4	2.31e-05	3	97	2	28639721
Pubmed	Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.	STAG1 STAG2	2.31e-05	3	97	2	38742641
Pubmed	Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.	ITPR1 ITPR3	2.31e-05	3	97	2	22992961
Pubmed	Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.	STAG1 STAG2	2.31e-05	3	97	2	24335498
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR3	2.31e-05	3	97	2	18194433
Pubmed	Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.	ITPR1 ITPR3	2.31e-05	3	97	2	12032348
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR3	2.31e-05	3	97	2	27777977
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR3	2.31e-05	3	97	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR3	2.31e-05	3	97	2	18241669
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR3	2.31e-05	3	97	2	19068129
Pubmed	Absence of innate MyD88 signaling promotes inducible allograft acceptance.	RAG1 CASP1	2.31e-05	3	97	2	17015716
Pubmed	Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.	ITPR1 ITPR3	2.31e-05	3	97	2	12421829
Interaction	CALM1 interactions	HSPE1 GAD2 MYO1D STAG1 MYO9B ANXA5 GRAMD1A ARHGEF17 ITPR1 GRAMD1B EGFR SNX6 TRPV4 HSPA4	1.35e-06	626	95	14	int:CALM1
Interaction	KCNA3 interactions	RPL27A ANK2 MYO1D NCKAP1 BZW2 ZC3H18 HNRNPD DDOST MYO5C PAPOLG TBC1D8 EGFR BZW1 MARK2 HSPA4 RPL8	2.90e-06	871	95	16	int:KCNA3
Interaction	CDH5 interactions	CHST10 UFSP2 MYO1D MYO9B MYO5C EGFR	1.28e-05	109	95	6	int:CDH5
Interaction	CITED1 interactions	STAG1 MYO9B USP11 STAG2	2.72e-05	37	95	4	int:CITED1
Interaction	PFN1 interactions	HSPE1 ANK2 MYO9B ANXA5 ITSN1 ZC3H18 RABGAP1 MYO5C GRID2IP SMG7 SNX6	2.76e-05	509	95	11	int:PFN1
Interaction	VCP interactions	HSPE1 RPL27A ERCC6 SYN3 MYO1D BZW2 USP11 ANXA5 RABGAP1 HNRNPD DDOST ITPR1 ITPR3 EGFR MARK2 CORO7 HSPA4 STAG2 RPL8	3.43e-05	1435	95	19	int:VCP
Interaction	SYNPO interactions	NCKAP1 CENPE SIPA1L3 ARHGEF17 MYO5C ITPR1 ITPR3	3.48e-05	192	95	7	int:SYNPO
Cytoband	19q13.13	SIPA1L3 GRAMD1A	4.56e-04	15	97	2	19q13.13
Cytoband	2q11.2	CHST10 TBC1D8 CNGA3	4.91e-04	72	97	3	2q11.2
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	GRAMD1A TBC1D8 GRAMD1B	1.29e-05	13	66	3	1146
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR3	3.93e-05	3	66	2	297
GeneFamily	Cohesin complex	STAG1 STAG2	3.62e-04	8	66	2	1060
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MYO1D CENPE ITPR1 ITPR3 NOM1	5.19e-04	181	66	5	694
GeneFamily	Cadherin related	CLSTN1 FAT2	1.72e-03	17	66	2	24
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN1 ARHGEF17 SOS2	1.80e-03	66	66	3	722
GeneFamily	POU class homeoboxes and pseudogenes	POU6F2 POU6F1	3.16e-03	23	66	2	523
GeneFamily	Transient receptor potential cation channels	TRPV4 TRPM8	4.67e-03	28	66	2	249
GeneFamily	Zinc fingers CCCH-type	ZC3H18 ZC3H6	7.23e-03	35	66	2	73
GeneFamily	Sulfotransferases, membrane bound	CHST10 CHST11	8.05e-03	37	66	2	763
Coexpression	GSE17186_BLOOD_VS_CORD_BLOOD_CD21HIGH_TRANSITIONAL_BCELL_DN	CHST10 PYROXD1 RRM2B GRAMD1A POU6F1 PAPOLG GRAMD1B	9.75e-06	200	97	7	M7186
Coexpression	BROWNE_HCMV_INFECTION_14HR_DN	ERCC6 CENPE CASP1 PAPSS2 ARHGEF17 AQP4 EGFR HSPA4	1.26e-05	290	97	8	M13251
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	STAG1 NCKAP1 CENPE MYO9B ITSN1 DDR2 RABGAP1 ITPR1 EGFR CDYL HERC4 STAG2 SOS2	1.63e-05	856	97	13	M4500
Coexpression	AMIT_EGF_RESPONSE_480_HELA	MYO9B CHST11 ITPR3 GRAMD1B EGFR CDYL	3.38e-05	164	97	6	M8729
Coexpression	GSE3920_IFNA_VS_IFNB_TREATED_ENDOTHELIAL_CELL_DN	MYO1D ITSN1 CASP1 ITPR1 GRAMD1B LLGL2	3.62e-05	166	97	6	M6701
Coexpression	GARY_CD5_TARGETS_DN	STAG1 ERAP1 CASP1 OAS1 CHST11 HNRNPD BZW1 HSPA4 SP140	3.78e-05	440	97	9	M13893
Coexpression	HOLLMANN_APOPTOSIS_VIA_CD40_DN	RAG1 BZW2 ANXA5 GMFG CASP1 RPL8 SP140	6.19e-05	267	97	7	M6663
Coexpression	LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q	ANK2 GRAMD1A RABGAP1 ALG2 NANS	7.25e-05	116	97	5	M8411
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	MYO9B ITSN1 CLSTN1 ARHGEF17 PLXNB2 ITPR1 ITPR3	7.62e-05	276	97	7	M3063
Coexpression	OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN	HIGD2A ERAP1 RABGAP1 SMG7 MAP3K2 SP140 SOS2	8.52e-05	281	97	7	M7089
Coexpression	GSE3982_MAC_VS_NEUTROPHIL_UP	HSPE1 MYO1D ERAP1 DDOST BZW1 RPL8	9.62e-05	198	97	6	M5491
Coexpression	GSE3982_EOSINOPHIL_VS_CENT_MEMORY_CD4_TCELL_DN	HIGD2A SYN3 KPNA6 RABGAP1 ITPR3 LTBP3	9.62e-05	198	97	6	M5419
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH2_UP	SIPA1L3 RABGAP1 ITPR3 LLGL2 SNX6 LTBP3	9.89e-05	199	97	6	M4526
Coexpression	GSE28783_ANTI_MIR33_VS_UNTREATED_ATHEROSCLEROSIS_MACROPHAGE_DN	CHST10 CENPE ARHGEF17 ITPR1 GUCY1A2 SOS2	9.89e-05	199	97	6	M8352
Coexpression	GSE29949_CD8_POS_DC_SPLEEN_VS_MONOCYTE_BONE_MARROW_DN	RPL27A PYROXD1 ITPR1 GRAMD1B STAG2 SP140	9.89e-05	199	97	6	M8415
Coexpression	GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_DN	HSPE1 STAG1 ANXA5 NANS CORO7 SOS2	9.89e-05	199	97	6	M4310
Coexpression	GSE19198_CTRL_VS_IL21_TREATED_TCELL_6H_UP	BZW2 ITSN1 GMFG PAPSS2 SNX6 QTRT1	1.02e-04	200	97	6	M7221
Coexpression	GSE18893_TCONV_VS_TREG_24H_CULTURE_UP	ANXA5 ITSN1 CDC42BPB ITPR1 GRAMD1B NFIX	1.02e-04	200	97	6	M7290
Coexpression	GOLDRATH_IMMUNE_MEMORY	NCKAP1 RRM2B POU6F1 SOS2	1.07e-04	66	97	4	M10845
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	RPL27A ERAP1 MYO9B GRAMD1A GMFG CASP1 CPA3 KPNA6 CHST11 ZC3H6 ITPR1 PAPOLG BZW1 STAG2 MAP3K2 SP140	1.12e-04	1492	97	16	M40023
Coexpression	GOLDRATH_IMMUNE_MEMORY	NCKAP1 RRM2B POU6F1 SOS2	1.27e-04	69	97	4	MM621
Coexpression	GSE9946_MATURE_STIMULATORY_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_DN	ANK2 ARHGEF17 EGFR TRPV4 HSD3B2	1.59e-04	137	97	5	M429
Coexpression	HAN_SATB1_TARGETS_UP	MYO1D PYROXD1 CASP1 OAS1 CDH19 PAPSS2 PLXNB2 ITPR1	1.84e-04	425	97	8	M9639
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MYO1D NCKAP1 CLSTN1 PLXNB2 FAT2 LLGL2 EGFR NFIX	1.36e-08	200	97	8	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYO1D PAPSS2 AQP4 MYO5C LLGL2 EGFR APOL6 LTBP3	1.36e-08	200	97	8	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYO1D NCKAP1 CLSTN1 PLXNB2 FAT2 LLGL2 EGFR NFIX	1.36e-08	200	97	8	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1D SIPA1L3 AQP4 MYO5C LLGL2 EGFR APOL6	1.79e-07	187	97	7	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PLXNB2 AQP4 MYO5C LLGL2 EGFR APOL6 LTBP3	2.55e-07	197	97	7	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYO1D PAPSS2 AQP4 MYO5C LLGL2 EGFR LTBP3	2.73e-07	199	97	7	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 ERCC6 SIPA1L3 POU6F1 TBC1D8 GRAMD1B	2.58e-06	178	97	6	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	MYO1D SIPA1L3 PAPSS2 AQP4 MYO5C LLGL2	3.23e-06	185	97	6	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	healthy_donor-Myeloid-Monocytic-CD16+_Monocyte\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	4.24e-06	194	97	6	ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PGM2L1 AQP4 EGFR NFIX LTBP3 CNGA3	4.24e-06	194	97	6	08fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell	myeloid-CD16+_Monocyte\|World / Lineage and Cell class	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	4.50e-06	196	97	6	225c102e0a2047425a7125eba1d2359159c50409
ToppCell	BLOOD--(3)_Non_classical_monocytes\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ANXA5 DDR2 CASP1 OAS1 PLXNB2 TBC1D8	4.50e-06	196	97	6	b5ce99e27c9e87be52c10c022a665bf4df0e8b05
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PLXNB2 AQP4 EGFR NFIX LTBP3	4.50e-06	196	97	6	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	control-Myeloid-CD16_Monocytes\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPL27A ANXA5 OAS1 PAPSS2 PLXNB2 RPL8	4.63e-06	197	97	6	cdb2866d5a8fbf39847309124479ad49c88852d4
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	4.77e-06	198	97	6	3bc3dbd178043deadd7eef413b2761dc003abd6e
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	4.77e-06	198	97	6	9b47585653aaebd033c9b7bba93c7a7c35a4d60e
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	4.77e-06	198	97	6	8b5d30312bbcabc6911ff03e5028766d77203dff
ToppCell	Control-Myeloid-Non-classical_Monocyte\|Control / Disease group, lineage and cell class	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	4.77e-06	198	97	6	ae0a51e63e2751a6d9dc0c8a3852680949173523
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ANK2 NCKAP1 DDR2 EGFR NFIX LTBP3	4.91e-06	199	97	6	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	PLXNB2 AQP4 MYO5C LLGL2 APOL6 LTBP3	5.05e-06	200	97	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	MS-Multiple_Sclerosis-Myeloid-CD16+_Monocyte\|Multiple_Sclerosis / Disease, condition lineage and cell class	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	5.05e-06	200	97	6	add2f9fbada3a68662edc8c756af90cdc380295b
ToppCell	Control-Control-Myeloid-CD16+_Monocyte\|Control / Disease, condition lineage and cell class	ANXA5 CASP1 OAS1 PAPSS2 PLXNB2 TBC1D8	5.05e-06	200	97	6	8dd124a5aca897652ea68efbfc5a167b4cf31aef
ToppCell	ASK454-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	GRAMD1A CPA3 PAPSS2 AQP4 LTBP3	1.88e-05	149	97	5	078792d5272f1881757dc47daa96e87449cf5d34
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITSN1 ALG2 ITPR1 TBC1D8 EGFR	4.17e-05	176	97	5	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITSN1 ALG2 ITPR1 TBC1D8 EGFR	4.17e-05	176	97	5	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1D AQP4 MYO5C LLGL2 EGFR	4.76e-05	181	97	5	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-DC3\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HSPE1 ANXA5 CASP1 DDOST NANS	5.02e-05	183	97	5	c6cac433ea7a3d60728efdc7051e09e01bb3ade5
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	MYO1D AQP4 MYO5C LLGL2 EGFR	5.02e-05	183	97	5	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1D AQP4 MYO5C LLGL2 EGFR	5.15e-05	184	97	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1D AQP4 MYO5C LLGL2 EGFR	5.15e-05	184	97	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	droplet-Mammary_Gland-nan-3m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPE1 RPL27A GRAMD1A GMFG RPL8	5.28e-05	185	97	5	02a2cbae9238c6c1e80b9a52a575e3b22f0eebb4
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1D AQP4 MYO5C LLGL2 EGFR	5.42e-05	186	97	5	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	5.42e-05	186	97	5	310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	MYO1D PAPSS2 AQP4 MYO5C LLGL2	5.56e-05	187	97	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	POU6F2 ITSN1 SIPA1L3 ITPR1 CDYL	5.70e-05	188	97	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	RRM2B AQP4 ITPR3 C16orf89 NFIX	5.85e-05	189	97	5	2d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	GMFG RABGAP1 ARHGEF17 GUCY1A2 SNX6	5.85e-05	189	97	5	f4865b7db16de15120504147a8016ac522ad242a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	5.99e-05	190	97	5	56cc761e50fddfb5366391518b4d8e16589b6b42
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	CCDC61 ITPR3 ZNF587 MARK2 HSPA4	5.99e-05	190	97	5	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	5.99e-05	190	97	5	25d4b591f75c26e404a34c42f1742d580af6598d
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAG1 HSPE1 GMFG MYO5C ITPR1	6.15e-05	191	97	5	40813c397f533c2f4a6359a77757f736b6d9e07d
ToppCell	facs-Heart-LV-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 ARHGEF17 ITPR1 GUCY1A2 EGFR	6.15e-05	191	97	5	b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 CDH19 ARHGEF17 ITPR1 GUCY1A2	6.15e-05	191	97	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	6.30e-05	192	97	5	f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPE1 RPL27A BZW2 AQP4 RPL8	6.30e-05	192	97	5	448b71c965e1b7addc6bccbcd6047cefda3d5b5a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	6.30e-05	192	97	5	690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCell	facs-Trachea-nan-3m-Epithelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP4 MYO5C C16orf89 FAT2 LLGL2	6.61e-05	194	97	5	3701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCell	facs-Trachea-nan-3m-Epithelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP4 MYO5C C16orf89 FAT2 LLGL2	6.61e-05	194	97	5	65f9bf126be26114c2c3f4c46d48318986212a92
ToppCell	10x5'v1-week_14-16-Myeloid_DC-DC-DC2\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	HIGD2A ANXA5 CASP1 DDOST RPL8	6.61e-05	194	97	5	a0cfc8c1cdc0722db39170e4417615b6e6b85041
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	6.61e-05	194	97	5	6ac759828c41ffa974ee82842162caa959351dd1
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC-DC2\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HSPE1 ANXA5 CASP1 DDOST NANS	6.61e-05	194	97	5	833c695779edc94690b08814b0dedcf00ae082cd
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CHST11 PAPSS2 EGFR	6.61e-05	194	97	5	5d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	AQP4 MYO5C ITPR3 C16orf89 LLGL2	6.78e-05	195	97	5	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	10x5'-blood-Myeloid_Monocytic-Nonclassical_monocytes\|blood / Manually curated celltypes from each tissue	ANXA5 OAS1 PAPSS2 PLXNB2 TBC1D8	6.78e-05	195	97	5	88d65c7c3a28922c125bd9f7c403a55d7d4d83a9
ToppCell	control-Non-classical_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANXA5 CASP1 OAS1 PAPSS2 TBC1D8	6.94e-05	196	97	5	1d71a5be652dd3281aba4f984f6ef84c993c5f63
ToppCell	Multiple_Sclerosis-Myeloid-CD16_Mono\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ANXA5 CASP1 OAS1 PLXNB2 TBC1D8	6.94e-05	196	97	5	83011b56780295dff5ded57064b07dcd2f19ea26
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST11 PAPSS2 ITPR3 TRPV4 BZW1	7.11e-05	197	97	5	8786125b669d5d0b15e12df0ade6b319f09f7333
ToppCell	10x5'-bone_marrow-Myeloid_Monocytic-Nonclassical_monocytes\|bone_marrow / Manually curated celltypes from each tissue	ANXA5 OAS1 PAPSS2 PLXNB2 TBC1D8	7.11e-05	197	97	5	dcf1e74b7c21466d38d68f44d404bce14ade2805
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANXA5 CASP1 OAS1 PLXNB2 TBC1D8	7.28e-05	198	97	5	cbbdd44dfa95370c0fbaa65ba71d86bfee0ea379
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	PAPSS2 AQP4 MYO5C LLGL2 LTBP3	7.28e-05	198	97	5	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	mild-Myeloid-CD16_Monocytes\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPL27A ANXA5 PAPSS2 PLXNB2 RPL8	7.28e-05	198	97	5	ba97ff6e9d400b53ad013dce54afd7154a0f4fc9
ToppCell	Healthy-Non-classical_Monocyte\|Healthy / disease group, cell group and cell class	ANXA5 CASP1 OAS1 PLXNB2 TBC1D8	7.28e-05	198	97	5	394e5fa8998c46c6f7cd57b53f347d2029c75ae1
ToppCell	Healthy-Non-classical_Monocyte\|World / disease group, cell group and cell class	ANXA5 CASP1 OAS1 PLXNB2 TBC1D8	7.28e-05	198	97	5	4fd27a9fb3758c94ed9f0a726296e92b0625da44
ToppCell	Control_saline-Epithelial_alveolar-AT_1\|Control_saline / Treatment groups by lineage, cell group, cell type	PAPSS2 AQP4 MYO5C LLGL2 LTBP3	7.28e-05	198	97	5	9b161285df7a4e51618f3517cfc5b8221ba55786
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANXA5 CASP1 OAS1 PLXNB2 TBC1D8	7.28e-05	198	97	5	7d8fade2583c07a33dd83057cbce08e9fc77987a
ToppCell	Control_saline-Epithelial_alveolar\|Control_saline / Treatment groups by lineage, cell group, cell type	AQP4 MYO5C C16orf89 LLGL2 LTBP3	7.28e-05	198	97	5	532b7ef4ad46fe35ad2c6bdf89f70a17f1a2e2e2
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANXA5 CASP1 OAS1 PLXNB2 TBC1D8	7.28e-05	198	97	5	165d60b111a17d517a420c434733eefb98da240d
ToppCell	C_03\|World / shred on cell type and cluster	HIGD2A BZW2 DDR2 CASP1 DDOST	7.46e-05	199	97	5	1ae1c7152a49a5484e715a1e084f6e02bdbcaca3
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MYO1D AQP4 MYO5C LLGL2 LTBP3	7.46e-05	199	97	5	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	VE-CD4-antiviral_CD4\|VE / Condition, Cell_class and T cell subcluster	CASP1 OAS1 SNX6 APOL6 SP140	7.46e-05	199	97	5	056a0538ca5e825ae6195b4c76c208708a014533
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AQP4 MYO5C LLGL2 APOL6 LTBP3	7.46e-05	199	97	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	severe-Myeloid-CD14_Monocytes_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPL27A HIGD2A ANXA5 PLXNB2 RPL8	7.64e-05	200	97	5	271afd2571a60240e827eaeb62fee0fc3f93c099
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PGM2L1 AQP4 EGFR NFIX QTRT1	7.64e-05	200	97	5	4c20102de2ff7a38e5bff5c65e9fbd0d0310a302
ToppCell	Lung_Parenchyma-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	AQP4 MYO5C ITPR3 C16orf89 LLGL2	7.64e-05	200	97	5	c2bde99b3bc7a8740441c1a0c1394892b940b857
ToppCell	COVID-19\|World / group, cell type (main and fine annotations)	HSPE1 RPL27A CHST11 APOL6 RPL8	7.64e-05	200	97	5	ac38a468559c33ee00152735ce6e408f3f48df84
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MYO1D AQP4 MYO5C LLGL2 LTBP3	7.64e-05	200	97	5	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ITSN1 DDR2 ITPR1 NFIX LTBP3	7.64e-05	200	97	5	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GAD2 DDR2 CHST11 PAPSS2 EGFR	7.64e-05	200	97	5	862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	AQP4 MYO5C ITPR3 C16orf89 LLGL2	7.64e-05	200	97	5	3ff9abd5e07780a59d5571da906fa15f00a1d5c2
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GAD2 DDR2 CHST11 PAPSS2 EGFR	7.64e-05	200	97	5	a91345f268f13170c27309333603eb82400c9947
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DDR2 CDH19 ARHGEF17 GUCY1A2 LTBP3	7.64e-05	200	97	5	67dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GAD2 DDR2 CHST11 PAPSS2 EGFR	7.64e-05	200	97	5	d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	AQP4 MYO5C ITPR3 C16orf89 LLGL2	7.64e-05	200	97	5	9970e9bde6aa2ff3aef60dcb065ff15b7463e147
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	DDR2 CDH19 ARHGEF17 PLXNB2 GUCY1A2	7.64e-05	200	97	5	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Thalamus / BrainAtlas - Mouse McCarroll V32	ITPR3 C16orf89 TRPV4 SP140	2.04e-04	133	97	4	29b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MYO9B ITSN1 PAPOLG TBC1D8	2.16e-04	135	97	4	b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UFSP2 PKD1L3 HNRNPD MYO5C	2.35e-04	138	97	4	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RPL27A AQP4 NANS RPL8	2.35e-04	138	97	4	615822e542f12aa83df1561e262b8d72bdefc60e
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-Lgr5+_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD2 RPL27A BZW2 RPL8	2.42e-04	139	97	4	c300f953ff9c5e820ff16bcd9942d279b37b79db
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD2 RPL27A BZW2 RPL8	2.42e-04	139	97	4	95b19d7459d9b54162cf01d278462245d34802d5
ToppCell	(00)_Basal\|World / shred by cell type and Timepoint	RPL27A CLSTN1 FAT2 RPL8	3.15e-04	149	97	4	49e39206f37cee124ca4763c79425b805e50624b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_GGT8P\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 DDR2 CPA3 EGFR	4.03e-04	159	97	4	72678dfedc152f524fac14ddb31d4fed1528d52a
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ITPR3 C16orf89 TRPV4 SP140	4.13e-04	160	97	4	04714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCell	Club-club-13\|World / Class top	DDR2 MYO5C C16orf89 NANS	4.32e-04	162	97	4	7d18f05a65ac715e62d610df9cc4a26539340dee
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	CENPE RRM2B HNRNPD NANS	4.43e-04	163	97	4	c1a98d6776b685f20dde049715233e5c73ce3244
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GAD2 DDR2 EGFR NFIX	4.53e-04	164	97	4	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5C C16orf89 LLGL2 TRPV4	4.53e-04	164	97	4	cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5C C16orf89 LLGL2 TRPV4	4.53e-04	164	97	4	5dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5C C16orf89 LLGL2 TRPV4	4.53e-04	164	97	4	f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCell	facs-Kidney-nan-24m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 BZW2 GMFG SP140	4.85e-04	167	97	4	3c4183a8225bae37b9f5341ebd1b95409ced2022
Drug	Heliotrine [303-33-3]; Up 200; 12.8uM; PC3; HT_HG-U133A	GAD2 MYO9B OAS1 HNRNPD PAPOLG FCF1 EGFR MARK2 SOS2	1.53e-07	197	96	9	3717_UP
Drug	Picrotoxinin [17617-45-7]; Down 200; 13.6uM; HL60; HT_HG-U133A	CHST11 ITPR1 FCF1 CDYL QTRT1 HSPA4 MAP3K2 SOS2	1.33e-06	188	96	8	2161_DN
Drug	Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A	FCF1 SMG7 NFIX PRR14L HERC4 HSPA4 MAP3K2 SOS2	1.38e-06	189	96	8	4271_DN
Drug	Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; PC3; HT_HG-U133A	MYO9B AQP4 ITPR1 ITPR3 FCF1 EGFR APOL6 TRPV4	1.62e-06	193	96	8	3708_UP
Drug	9 mM of H	GAD2 ITPR1 ITPR3	4.01e-06	8	96	3	CID000130464
Drug	decanamide	RAG1 GAD2 MYO1D MYO9B EGFR MARK2 SOS2	5.46e-06	161	96	7	CID000075347
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	ITSN1 CASP1 HNRNPD GRAMD1B HERC4 HSPA4 SOS2	8.42e-06	172	96	7	1159_UP
Drug	aerobactin	STAG1 ARHGEF17 PAPOLG NANS	8.56e-06	31	96	4	CID000123762
Drug	R 478	ITPR1 ITPR3 HSPA4	1.17e-05	11	96	3	CID000084223
Drug	Isocaffeine	ITPR1 ITPR3	1.76e-05	2	96	2	CID000001326
Drug	adenophostin B	ITPR1 ITPR3	1.76e-05	2	96	2	CID000656722
Drug	benzene 1,2,4-trisphosphate	ITPR1 ITPR3	1.76e-05	2	96	2	CID000192376
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	RABGAP1 FCF1 NFIX CDYL PRR14L HERC4 SOS2	1.84e-05	194	96	7	4312_DN
Drug	Allantoin [97-59-6]; Down 200; 25.2uM; PC3; HT_HG-U133A	NCKAP1 SIPA1L3 CASP1 FCF1 EGFR APOL6 SOS2	1.96e-05	196	96	7	5052_DN
Drug	Nifenazone [2139-47-1]; Down 200; 13uM; PC3; HT_HG-U133A	ITSN1 CASP1 KPNA6 CHST11 HNRNPD QTRT1 MAP3K2	1.96e-05	196	96	7	7314_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A	CHST10 STAG1 ITPR1 PAPOLG SMG7 QTRT1 HERC4	2.10e-05	198	96	7	6332_DN
Drug	Acetohexamide [968-81-0]; Down 200; 12.4uM; PC3; HT_HG-U133A	CHST10 UFSP2 MYO1D NCKAP1 CDC42BPB CDYL SOS2	2.24e-05	200	96	7	1829_DN
Drug	Carteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	POU6F2 SIPA1L3 OAS1 RABGAP1 ITPR3 GUCY1A2 APOL6	2.24e-05	200	96	7	4176_UP
Drug	Calcium	ANXA5 POU6F1 CDC42BPB HNRNPD ALG2 ITPR1 ITPR3 EGFR TRPV4 TRPM8	4.42e-05	493	96	10	ctd:D002118
Drug	5-deoxy-5-fluoro-myo-inositol	ITPR1 ITPR3	5.26e-05	3	96	2	CID000195110
Drug	N-ethylmaleimide	GAD2 SYN3 MYO1D MYO9B CASP1 CPA3 MYO5C PAPOLG EGFR HSPA4	5.96e-05	511	96	10	CID000004362
Drug	isradipine	GAD2 PKD1L3 ITPR1 ITPR3 HSPA4	6.58e-05	100	96	5	CID000003784
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	CASP1 PAPSS2 HNRNPD GRAMD1B MARK2 HERC4	8.44e-05	170	96	6	1167_UP
Drug	lavendustin A	CASP1 PKD1L3 ITPR1 ITPR3 EGFR CNGA3	8.72e-05	171	96	6	CID000003894
Drug	17-DMAG; Up 200; 0.1uM; HL60; HT_HG-U133A	CASP1 PAPSS2 HNRNPD MYO5C HERC4 HSPA4	9.59e-05	174	96	6	2673_UP
Drug	CHEBI:697555	ITPR1 ITPR3	1.05e-04	4	96	2	CID009578246
Drug	geldanamycin; Up 200; 1uM; PC3; HT_HG-U133A	OAS1 POU6F1 HNRNPD GRAMD1B FAT2 SMG7	1.12e-04	179	96	6	4452_UP
Drug	Ac-devd-amc	ANXA5 CASP1 HSPA4	1.21e-04	23	96	3	CID000001992
Drug	poly(G	STAG1 GMPR2 HNRNPD PAPOLG STAG2	1.23e-04	114	96	5	CID000439502
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; HL60; HT_HG-U133A	ITSN1 CASP1 HNRNPD MYO5C HSPA4 SOS2	1.23e-04	182	96	6	1160_UP
Drug	IAA-94	ANXA5 PKD1L3 ITPR1 ITPR3	1.29e-04	61	96	4	CID000003667
Drug	Rapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A	CASP1 OAS1 RABGAP1 GUCY1A2 EGFR TRPV4	1.34e-04	185	96	6	4445_UP
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A	FCF1 SMG7 NFIX PRR14L HERC4 SOS2	1.55e-04	190	96	6	4307_DN
Drug	Flunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT_HG-U133A	RABGAP1 FCF1 NFIX PRR14L HERC4 SOS2	1.60e-04	191	96	6	4303_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A	FCF1 SMG7 NFIX PRR14L HERC4 SOS2	1.60e-04	191	96	6	4283_DN
Drug	Selegiline hydrochloride [14611-52-0]; Down 200; 17.8uM; MCF7; HT_HG-U133A	GAD2 MYO9B ARHGEF17 FCF1 MARK2 HERC4	1.69e-04	193	96	6	4146_DN
Drug	Oxantel pamoate [68813-55-8]; Down 200; 6.6uM; MCF7; HT_HG-U133A	UFSP2 CASP1 FCF1 CDYL QTRT1 MAP3K2	1.74e-04	194	96	6	2632_DN
Drug	Midodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; PC3; HT_HG-U133A	OAS1 PAPSS2 ITPR1 EGFR PRR14L HSPA4	1.74e-04	194	96	6	2087_DN
Drug	Parbendazole [14255-87-9]; Up 200; 16.2uM; PC3; HT_HG-U133A	OAS1 POU6F1 ARHGEF17 ITPR3 SMG7 TRPV4	1.74e-04	194	96	6	3799_UP
Drug	Furazolidone [67-45-8]; Down 200; 17.8uM; MCF7; HT_HG-U133A	ERAP1 MYO9B RABGAP1 ITPR1 SMG7 SOS2	1.74e-04	194	96	6	4178_DN
Drug	AC1L4NPY	STAG1 STAG2	1.74e-04	5	96	2	CID000160495
Drug	Sa-6	STAG1 STAG2	1.74e-04	5	96	2	CID000056560
Drug	erionite	CASP1 EGFR	1.74e-04	5	96	2	ctd:C083174
Drug	L-ester	ANXA5 CASP1 EGFR	1.76e-04	26	96	3	CID000467321
Drug	Ticlopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; MCF7; HT_HG-U133A	GAD2 MYO9B SIPA1L3 ITPR1 HERC4 SOS2	1.79e-04	195	96	6	4155_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A	ARHGEF17 FCF1 SMG7 MARK2 MAP3K2 SOS2	1.84e-04	196	96	6	5425_DN
Drug	Benzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; HL60; HT_HG-U133A	ERAP1 ITSN1 MYO5C PAPOLG FCF1 QTRT1	1.84e-04	196	96	6	6155_DN
Drug	quercetin dihydrate; Up 200; 1uM; MCF7; HG-U133A	ITSN1 KPNA6 ARHGEF17 ITPR3 SMG7 MARK2	1.84e-04	196	96	6	283_UP
Drug	Tolnaftate [2398-96-1]; Up 200; 13uM; MCF7; HT_HG-U133A	NCKAP1 PAPSS2 HERC4 HSPA4 MAP3K2 SOS2	1.84e-04	196	96	6	4805_UP
Drug	Dipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	CHST10 MYO9B SIPA1L3 CDC42BPB EGFR MAP3K2	1.84e-04	196	96	6	7124_DN
Drug	Benzthiazide [91-33-8]; Up 200; 9.2uM; PC3; HT_HG-U133A	RAG1 ERAP1 CASP1 SMG7 GUCY1A2 SOS2	1.84e-04	196	96	6	6607_UP
Drug	Trioxsalen [3902-71-4]; Down 200; 17.6uM; HL60; HT_HG-U133A	ANK2 SIPA1L3 GRAMD1B CDYL QTRT1 SOS2	1.84e-04	196	96	6	2516_DN
Drug	pyrithione zinc	HSPE1 ANXA5 CASP1 HSPA4	1.86e-04	67	96	4	ctd:C010423
Drug	Isoxicam [34552-84-6]; Up 200; 12uM; MCF7; HT_HG-U133A	NCKAP1 CASP1 ITPR1 CDYL HSPA4 MAP3K2	1.89e-04	197	96	6	1698_UP
Drug	Nisoxetine hydrochloride [57754-86-6]; Up 200; 13uM; HL60; HT_HG-U133A	GAD2 ERAP1 SIPA1L3 POU6F1 GRAMD1B GUCY1A2	1.89e-04	197	96	6	3117_UP
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	CHST10 MYO9B SMG7 GUCY1A2 EGFR SOS2	1.89e-04	197	96	6	4764_DN
Drug	Famotidine [76824-35-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CHST10 SIPA1L3 PAPOLG CDYL HSPA4 SOS2	1.89e-04	197	96	6	1529_DN
Drug	Triamterene [396-01-0]; Down 200; 15.8uM; PC3; HT_HG-U133A	ITSN1 CHST11 ITPR1 PAPOLG SMG7 NFIX	1.94e-04	198	96	6	7307_DN
Drug	Clindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; PC3; HT_HG-U133A	GAD2 POU6F2 ITSN1 SIPA1L3 QTRT1 SOS2	1.94e-04	198	96	6	5815_UP
Drug	Amoxapine [14028-44-5]; Down 200; 12.8uM; HL60; HG-U133A	STAG1 CASP1 MYO5C SMG7 SNX6 HSPA4	1.94e-04	198	96	6	2013_DN
Drug	ICI 182,780; Up 200; 0.01uM; HL60; HT_HG-U133A	ITSN1 OAS1 FCF1 APOL6 MARK2 SOS2	2.00e-04	199	96	6	1179_UP
Drug	Diphemanil methylsulfate [62-97-5]; Up 200; 10.2uM; HL60; HG-U133A	STAG1 ITSN1 CASP1 ITPR1 SNX6 QTRT1	2.00e-04	199	96	6	1994_UP
Drug	Dobutamine hydrochloride [49745-95-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CHST10 ERAP1 MYO9B AQP4 ITPR1 EGFR	2.00e-04	199	96	6	3206_UP
Drug	0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A	PAPOLG SMG7 NFIX PRR14L MARK2 SOS2	2.00e-04	199	96	6	4334_UP
Drug	Trimethoprim [738-70-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A	ERAP1 SIPA1L3 RABGAP1 ARHGEF17 SMG7 HERC4	2.05e-04	200	96	6	4701_DN
Disease	Adenocarcinoma of lung (disorder)	RPL27A BZW2 ANXA5 DDR2 AQP4 EGFR	5.58e-05	206	95	6	C0152013
Disease	hearing threshold measurement, pure tone hearing measurement	TBC1D8 TRPV4	1.02e-04	5	95	2	EFO_0007617, EFO_0007618
Disease	Large cell carcinoma of lung	DDR2 CDC42BPB MAP3K2	1.50e-04	32	95	3	C0345958
Disease	Neurodevelopmental Disorders	ANK2 NCKAP1 CDC42BPB ITPR1	2.36e-04	93	95	4	C1535926
Disease	Dupuytren Contracture	POU6F2 MYO1D DDR2 TULP1	4.18e-04	108	95	4	EFO_0004229
Disease	Bone Diseases	TRPV4 LTBP3	4.54e-04	10	95	2	C0005940
Disease	hypertension	MYO1D ERAP1 MYO9B OAS1 PLXNB2 SOS2	4.83e-04	307	95	6	EFO_0000537
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR3	6.63e-04	12	95	2	DOID:1441 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	PLXNB2 TULP1 ITPR1 ITPR3 CORO7	6.67e-04	215	95	5	DOID:9970 (implicated_via_orthology)
Disease	Neoplasm of lung	ERCC6 EGFR	9.10e-04	14	95	2	cv:C0024121
Disease	Lung cancer	ERCC6 EGFR	9.10e-04	14	95	2	cv:C0242379
Disease	LUNG CANCER	ERCC6 EGFR	9.10e-04	14	95	2	211980
Disease	Status Epilepticus	RRM2B CASP1 AQP4	1.39e-03	68	95	3	C0038220
Disease	Alzheimer's disease (is_marker_for)	ANXA5 CASP1 AQP4 ITPR1 HSD3B2	1.48e-03	257	95	5	DOID:10652 (is_marker_for)
Disease	transient cerebral ischemia (biomarker_via_orthology)	ERCC6 ANK2 AQP4 ITPR1	1.69e-03	157	95	4	DOID:224 (biomarker_via_orthology)
Disease	response to COVID-19 vaccine, SARS-CoV-2 neutralizing antibody measurement	GUCY1A2 EGFR	1.88e-03	20	95	2	EFO_0803359, EFO_0803362
Disease	Disproportionate short stature	DDR2 PAPSS2 TRPV4	1.99e-03	77	95	3	C0878659
Disease	Headache, HbA1c measurement	DDR2 HSPA4	2.07e-03	21	95	2	EFO_0004541, HP_0002315
Disease	Hodgkins lymphoma	ERAP1 PAPOLG MAGEC1	2.38e-03	82	95	3	EFO_0000183
Disease	Carcinoma of lung	ERCC6 EGFR	2.48e-03	23	95	2	C0684249
Disease	blood zinc measurement	SYN3 SIPA1L3	2.48e-03	23	95	2	EFO_0007584
Disease	triacylglycerol 56:4 measurement	SYN3 MAGEC1	2.70e-03	24	95	2	EFO_0010431
Disease	bilirubin measurement	STAG1 PYROXD1 MYO9B SIPA1L3 TRPM8 SOS2	3.09e-03	442	95	6	EFO_0004570

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFCPDVEFKRRFKEA	AQP4	251	P55087
TRKRDEKEKFEPTVF	BZW2	16	Q9Y6E2
KAFRPELREEFSKLQ	HSD3B2	36	P26439
RALRFDPTAFVKAKE	CCDC61	341	Q9Y6R9
FSRRVKRREKQFPDS	C16orf89	306	Q6UX73
FKTRKRDEKERFDPT	BZW1	16	Q7L1Q6
IFLREFPRLKEDLKG	APOL6	41	Q9BWW8
FRKFLPLFDRVLVER	HSPE1	6	P61604
RLIFLFRQDPSEEKK	CLSTN1	426	O94985
RSEIDLFNIRKEFRK	ANXA5	276	P08758
FLTNRVLKDPKQRRF	ERCC6	981	Q03468
EDFRKLFSKLPEAER	GRAMD1A	91	Q96CP6
EDFRKLFKQLPDTER	GRAMD1B	96	Q3KR37
KLFRVRSFEKTPEEA	RAG1	31	P15918
ETFVSLVRKNREPRF	ITPR3	616	Q14573
RVAKEARPAFLKFLE	ARHGEF17	1176	Q96PE2
FKENRLPLFVKVRDT	ANK2	1406	Q01484
KFFRVQLPKRYRSEE	RABGAP1	781	Q9Y3P9
FISPFAKDRENARKI	PAPSS2	121	O95340
ERRILEAKQKGFVPF	GAD2	316	Q05329
NTPRVVDRFVEFLKR	KPNA6	121	O60684
KDIRPEFREDFVLTI	NFIX	81	Q14938
FPVIFRKAREFIEIL	MAGEC1	946	O60732
KIRFQESEERPKLFE	HSPA4	686	P34932
PVRERLKRDLFQFNK	LLGL2	11	Q6P1M3
DPELTEKLRKFRFRK	GMFG	11	O60234
DTFVSLVRKNREPRF	ITPR1	616	Q14643
FDELQRPFEEKLKKR	NLRP10	251	Q86W26
KDVAVEEFPRKLLTF	DDR2	551	Q16832
VAFRLPRVRKEFFQD	CORO7	811	P57737
EPAFKASFSIKIRRE	ERAP1	196	Q9NZ08
RPRKLDFFRSEKELN	PLXNB2	21	O15031
PFRREKEVSIFLQLR	FAT2	541	Q9NYQ8
ITVFRLPQKEARFKA	OR52A1	226	Q9UKL2
KSIFERLRNFDSPKE	PGM2L1	501	Q6PCE3
IVLEPRKSDFFINKR	HERC4	21	Q5GLZ8
RDFLKRIFVEAKLRP	MAP3K2	591	Q9Y2U5
EIREFAKNFKIRRLS	POU6F1	146	Q14863
EHFVEFVKDVRKRFP	GMPR2	136	Q9P2T1
RSKRRFVFKVPEEER	CDC42BPB	1551	Q9Y5S2
RERAFSVKFEVQAPR	OAS1	111	P00973
EFVRIDPFVRTFLKK	DDOST	356	P39656
VVFRDPYRFKKRTEL	RPL8	61	P62917
NPESFKEKFVRKTRE	HIGD2A	31	Q9BW72
AVKFIVRKFPAVETR	NCKAP1	56	Q9Y2A7
VEKFIRLESTFKDPR	PAPOLG	661	Q9BWT3
DSRPKFRELIIEFSK	EGFR	956	P00533
IIRRVFEKFVASPLA	CERS3	51	Q8IU89
IFIPKKHRARFDEVV	GRID2IP	196	A4D2P6
IAPVRFDREKVFRVK	CPA3	16	P15088
FDREKVFRVKPQDEK	CPA3	21	P15088
VEEIFRKVRFSFEQP	CASP1	366	P29466
SKRKFIDDRRDQPFD	CDYL	311	Q9Y232
KYRVALRIAKDPRFE	FCF1	116	Q9Y324
LPVTFEDKKRENFER	ITSN1	346	Q15811
LEEDPVTKERTFKRF	CNPY1	6	Q3B7I2
ALARERFKVVFAPVI	LTBP3	56	Q9NS15
EKEEFREAKPRSLRF	MARK2	681	Q7KZI7
RRKQILFPEKSEDFR	CDH19	621	Q9H159
KIKKFPDREFLLRVS	CENPE	116	Q02224
RVLEFQDFTVPRKRR	PRR14L	2086	Q5THK1
PVIVKAKFFSRRAEE	RPL27A	121	P46776
LKREESFTFIPRSRE	GUCY1A2	666	P33402
KRRGFCFITFKEEEP	HNRNPD	221	Q14103
KVVSRSFKPDFILVR	SYN3	151	O14994
IKVFREAFLSDRKLF	SOS2	221	Q07890
RTSIVEKRFPDFVRD	QTRT1	361	Q9BXR0
LEEIREFAKAFKIRR	POU6F2	481	P78424
PLREKLEEQFKRLLF	SMG7	271	Q92540
DRVFIPVSKRELFSF	PKD1L3	856	Q7Z443
FRKSDVFRDFLLAKV	SIPA1L3	786	O60292
SELEFKFNRKALERP	NANS	56	Q9NR45
KVVEFSELDKPRVRF	NOM1	766	Q5C9Z4
RARVKEKFSPEAFTE	ALG2	391	Q9H553
RPKRATEKFEEFLAI	CNBD1	126	Q8NA66
FIVRDPFERLISAFK	CHST10	186	O43529
KFLFVREPFERLVSA	CHST11	181	Q9NPF2
PEVRFNRLLKFSRLF	CNGA3	271	Q16281
RFIQFEPEEDIKRKF	UFSP2	86	Q9NUQ7
IRDPKKREFLFNAIE	RRM2B	146	Q7LG56
TVYARFLRDPEAKKR	TULP1	86	O00294
DDFRKIPSLFEIVVK	ZC3H6	421	P61129
EVRSLPKTDRFFKKV	UBTFL1	201	P0CB47
EFRILKKKSFTFPRD	PYROXD1	271	Q8WU10
SKNRRERTELKPDFF	STAG2	1201	Q8N3U4
EPEKFREALVKFEAR	TBC1D8	136	O95759
RKLRVSQEPFVFREF	ZNF587	161	Q96SQ5
RKLRVSQEPFVFREF	ZNF417	161	Q8TAU3
RELFPKLELFTNRFK	STAG1	361	Q8WVM7
ELIDFKTRRVAAFRK	SNX6	361	Q9UNH7
PIFRFFRENKVEIAS	SP140	41	Q13342
LIKDRPKFVRLFLEN	TRPM8	466	Q7Z2W7
FSREKLDTLVEFPIR	USP11	836	P51784
ILDIERSFPVFLRKA	TRPV4	741	Q9HBA0
TIRKEQEPDFEEKRF	ZC3H18	316	Q86VM9
PKVLRRFEEALQTIF	MYO1D	766	O94832
IDDFEKRVTPSFVRK	MYO5C	1676	Q9NQX4
EPFFIRCIRSNAEKK	MYO9B	846	Q13459