Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin filament binding

FLII MACF1 FLNC ACTN4

2.32e-04227274GO:0051015
DomainCH

EHBP1 MACF1 FLNC ACTN4

2.57e-0665284SM00033
DomainCH

EHBP1 MACF1 FLNC ACTN4

3.46e-0670284PF00307
Domain-

EHBP1 MACF1 FLNC ACTN4

3.66e-06712841.10.418.10
DomainCH

EHBP1 MACF1 FLNC ACTN4

4.10e-0673284PS50021
DomainCH-domain

EHBP1 MACF1 FLNC ACTN4

4.56e-0675284IPR001715
DomainActinin_actin-bd_CS

MACF1 FLNC ACTN4

5.24e-0623283IPR001589
DomainACTININ_2

MACF1 FLNC ACTN4

5.24e-0623283PS00020
DomainACTININ_1

MACF1 FLNC ACTN4

5.24e-0623283PS00019
DomainSpectrin

MACF1 ACTN4

5.38e-0423282PF00435
DomainSpectrin_repeat

MACF1 ACTN4

8.58e-0429282IPR002017
DomainSpectrin/alpha-actinin

MACF1 ACTN4

1.05e-0332282IPR018159
DomainSPEC

MACF1 ACTN4

1.05e-0332282SM00150
DomainEFh

MACF1 ACTN4 ZZEF1

1.67e-03158283SM00054
DomainEF_HAND_2

MACF1 ACTN4 ZZEF1

4.87e-03231283PS50222
DomainEF_hand_dom

MACF1 ACTN4 ZZEF1

4.93e-03232283IPR002048
Domain-

MACF1 ACTN4 ZZEF1

6.83e-032612831.10.238.10
DomainEF-hand-dom_pair

MACF1 ACTN4 ZZEF1

8.85e-03287283IPR011992
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

IPO5 EIF5B TUBB6 FLII MACF1 FLNC ACTN4 UBXN1 ZZEF1 PPP4R3A

1.05e-071455281022863883
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

BLM EIF5B SNX27 TUBB6 FLII MACF1 FLNC ACTN4 UBXN1

7.03e-07135328929467282
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

BLM IPO5 EIF5B TUBB6 FLII FLNC

2.30e-0649428626831064
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

IPO5 EIF5B TUBB6 MACF1 FLNC ACTN4 ZZEF1

2.73e-0680728730575818
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

IPO5 EIF5B SNX27 FLNC ACTN4

7.50e-0634428530333137
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

BLM IPO5 EIF5B MACF1 FLNC ACTN4

1.13e-0565328622586326
Pubmed

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

SNX27 MACF1 PDE4DIP

1.26e-05562839455484
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

IPO5 EIF5B TUBB6 FLII MACF1 FLNC ACTN4

1.29e-05102428724711643
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

FLII MACF1 FLNC ACTN4

1.63e-0519128433762435
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

IPO5 EIF5B TUBB6 MACF1 FLNC ACTN4

1.78e-0570728619738201
Pubmed

The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes.

TUBB6 FLNC ACTN4 UBXN1

2.45e-0521228423463506
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

IPO5 EIF5B TUBB6 FLII MACF1 FLNC ACTN4

2.72e-05114928735446349
Pubmed

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

IPO5 TUBB6 FLII FLNC ACTN4

3.29e-0546828536042349
Pubmed

Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.

TUBB6 MACF1 FLNC ACTN4

3.66e-0523528428378594
Pubmed

A human MAP kinase interactome.

EHBP1 MACF1 FLNC ACTN4 PPP4R3A

3.93e-0548628520936779
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

EHBP1 EIF5B MACF1 PDZRN3 PPP4R3A

4.21e-0549328515368895
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

IPO5 MACF1 FLNC ACTN4 PDE4DIP

4.37e-0549728523414517
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

EIF5B TUBB6 FLII PDZRN3

4.66e-0525028433536335
Pubmed

Filamin C is Essential for mammalian myocardial integrity.

FLNC ACTN4

5.65e-051428236706168
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

IPO5 TUBB6 ACTN4

8.06e-0510428336055981
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

IPO5 EIF5B TUBB6 FLII MACF1 ACTN4 UBXN1

1.01e-04141528728515276
Pubmed

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.

FLII ACTN4

1.06e-041928216105984
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

IPO5 SNX27 FLII MACF1 FLNC ACTN4 PDE4DIP

1.09e-04143128737142655
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

IPO5 EIF5B TUBB6 ACTN4 PPP4R3A

1.42e-0463828533239621
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

SNX27 TUBB6 FLII ACTN4 UBXN1

1.51e-0464728526618866
Pubmed

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

IPO5 MACF1 FLNC ACTN4

1.54e-0434128429791485
Pubmed

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.

EHBP1 CXCR2

1.56e-042328220468071
Pubmed

PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.

PPP4R3A PDE4DIP

1.71e-042428224710276
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

TUBB6 FLII MACF1 FLNC

1.90e-0436028433111431
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

IPO5 EIF5B PDE4DIP CAPN6

1.96e-0436328414691545
Pubmed

Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.

MACF1 PDE4DIP

2.17e-042728218685082
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

IPO5 MACF1 PDE4DIP

2.43e-0415128317043677
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

BLM MACF1 PDE4DIP

2.47e-0415228334299191
Pubmed

UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.

IPO5 TUBB6 MACF1

2.62e-0415528334921745
Pubmed

Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.

FLNC PDE4DIP

3.25e-04332828681137
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

SNX27 PDZRN3

3.45e-043428230726710
Pubmed

Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.

EIF5B MACF1

3.87e-043628216097034
Pubmed

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

SNX27 PDZRN3

3.87e-043628226053890
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

IPO5 EIF5B ACTN4

3.99e-0417928336261009
Pubmed

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

IPO5 ACTN4 UBXN1

4.47e-0418628314744259
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

BLM EHBP1 TUBB6 ACTN4 UBXN1 PDE4DIP

4.87e-04129328615342556
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

IPO5 EIF5B EDEM3 MACF1 ACTN4 UBXN1

4.95e-04129728633545068
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

TUBB6 MACF1 FLNC ACTN4 UBXN1

5.14e-0484428525963833
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

SNX27 MACF1 PDE4DIP

5.28e-0419728336604605
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

BLM EHBP1 EIF5B SNX27 ACTN4 PPP4R3A

5.45e-04132128627173435
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

EIF5B TUBB6 FLNC ACTN4

5.51e-0447728431300519
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

IPO5 EIF5B FLII

5.68e-0420228333005030
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

SNX27 MACF1 ACTN4 UBXN1

5.69e-0448128428190767
Pubmed

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

FLII ACTN4

6.06e-044528222114352
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

IPO5 EIF5B MACF1 PPP4R3A

6.47e-0449828436634849
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

BLM EIF5B FLII CDCA5

6.72e-0450328416964243
Pubmed

RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.

FLII ACTN4

7.48e-045028230413534
Pubmed

Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.

IPO5 EIF5B FLNC

7.77e-0422528331478661
InteractionST13 interactions

EIF5B MACF1 ACTN4 OLFM2 CXCR2

5.47e-06195275int:ST13
GeneFamilyPDZ domain containing

SNX27 PDZRN3

9.84e-031521821220
GeneFamilyEF-hand domain containing

MACF1 ZZEF1

1.97e-02219182863
CoexpressionHOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP

IPO5 FLII ACTN4 CDCA5

2.05e-05153284M5588
CoexpressionHOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP

IPO5 FLII ACTN4 CDCA5

2.16e-05155284MM1259
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

FLNC ACTN4 PDZRN3 PDE4DIP

5.71e-061892840a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OLFM2 GALNT3 CDCA5

4.34e-05109283e3696d84da1dcd15f15d0434ea9d1955f2af22d6
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendendrocytes_NG2_cells_(Tnr-Cspg5)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OLFM2 GALNT3 CDCA5

4.34e-051092836678036ff66c825a18d2506e33be421c27cf82e1
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendendrocytes_NG2_cells_(Tnr-Cspg5)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OLFM2 GALNT3 CDCA5

4.34e-0510928387f647cfebbb7de725e434cc27058e1c6accbb90
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P3|Entopeduncular / BrainAtlas - Mouse McCarroll V32

OLFM2 GALNT3 CDCA5

4.34e-05109283c9d1e69f9841135f4d114563a293a69a8ba5f965
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ACTN4 CDCA5 SPRYD3

1.14e-04151283def98dc2a8226295b62de2b7f1b587e03a4f038c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MACF1 FLNC ACTN4

1.14e-04151283b545823113a3450c5f841f7de48bf0937593544f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MACF1 FLNC ACTN4

1.14e-041512830cc2f4aec3dae4603fa831f22c40f897e68b34e2
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC OLFM2 PDZRN3

1.33e-041592837cda111bb98f1241989e49d490bdf51a712ea589
ToppCelldroplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC PDZRN3 CAPN6

1.62e-0417028310e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BLM TUBB6 CDCA5

1.73e-04174283c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCelldroplet-Marrow-nan-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBB6 ZZEF1 PDE4DIP

1.73e-0417428355cc8300489d11322724159ec7d0e1d32a702e91
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Neutrophil|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BLM CXCR2 SPRYD3

1.79e-04176283676839d07450b313222622e0ffd305c732cbad6d
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MACF1 PPP4R3A CXCR2

1.82e-04177283d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MACF1 PPP4R3A CXCR2

1.82e-04177283f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

MACF1 PPP4R3A CXCR2

1.82e-04177283936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MACF1 PPP4R3A CXCR2

1.82e-04177283d5aeda113afaa2425874394610344570c9078478
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

BLM OLFM2 PPP4R3A

1.82e-0417728336b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

MACF1 PPP4R3A CXCR2

1.82e-041772836978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM FLNC TAGAP

1.85e-0417828341745a589567ca5ea6d06331f4c8da03595b5f5c
ToppCellASK440-Epithelial-Transformed_epithelium|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

EHBP1 FLNC CYB5RL

1.85e-0417828386f1741636ed3e85bb4a65f84949b718fc38c290
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM FLNC TAGAP

1.85e-04178283eb940dd64c973f68bcaad6069d3bd56383329db5
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TUBB6 FLNC PDZRN3

1.95e-04181283fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLNC PDZRN3 PDE4DIP

1.95e-04181283719eb532453ab7cd7893726885bc75d74a10b21e
ToppCellCOVID-19_Mild-NK_activated|COVID-19_Mild / Disease condition and Cell class

MACF1 PPP4R3A CXCR2

2.01e-0418328322bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TUBB6 FLNC CYB5RL

2.04e-04184283968afa6b5ba84169377a24c150bb68749fa674d9
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

FLNC PDZRN3 PDE4DIP

2.04e-04184283ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TUBB6 FLNC CYB5RL

2.04e-0418428315cbddea9efb2346a2028d77edfe9ba32923568f
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TUBB6 FLNC CYB5RL

2.04e-041842830087c605c161fd8a39aa394f51994a04e8353bf1
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TUBB6 FLNC CYB5RL

2.04e-04184283920f95625978132c2b6c76654ef6298244103e2d
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TUBB6 FLNC CYB5RL

2.04e-041842831a4297b9d3cc4744bea0408fd5ee7b33ba2a1d78
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

MACF1 PPP4R3A CXCR2

2.04e-04184283791f1bcb954aadc63d4117c400537d036f68734d
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

EHBP1 FLII PHF13

2.04e-04184283d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLNC PDZRN3 PDE4DIP

2.08e-04185283549eeb521c3985bff396ea0f202db21822efa51f
ToppCelldroplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BLM CDCA5 ANAPC15

2.18e-041882830ec2a1b0505501ba18f10a5fce68c306a6292419
ToppCellASK454-Endothelial-Lymphatic|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ZZEF1 ANAPC15 SPRYD3

2.21e-04189283316c857dec9383823e09f966bca62d52d933b141
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

FLNC ACTN4 PDE4DIP

2.25e-0419028393c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BLM TUBB6 CDCA5

2.25e-0419028331de1727822e9818652946dfb962daee77ffad68
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BLM TUBB6 CDCA5

2.28e-04191283f764cc21fef87ebad765011098f647ae1bdf6158
ToppCellNS-moderate-d_0-4-Lymphoid|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

BLM TAGAP CDCA5

2.32e-04192283905217dcfc843d3469e9e71bd33707863b14cc82
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLNC OLFM2 CAPN6

2.35e-0419328302dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FLNC TAS2R50 CAPN6

2.35e-041932833d85c28f6ebdcb15e875ad01d52d6c138fbf8525
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MACF1 ACTN4 GALNT3

2.39e-0419428324837a27b0041fe8c348225fa8b09b127d743603
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TUBB6 FLNC CYB5RL

2.39e-04194283937ee85ffd50869b60f0f6e91017ab77e8b24c0b
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BLM TUBB6 CDCA5

2.42e-04195283926eb3fc5d028be936885bea0654a77db3107234
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC PDZRN3 CAPN6

2.46e-041962835159d8625d80c20eb28157b2603c8bde9d377a35
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC PDZRN3 CAPN6

2.46e-041962836b5b7dbcb2cce8a736e44145a01290905876a5e9
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TUBB6 MACF1 CAPN6

2.46e-04196283028a06ed92f1c058dcbeacd335625bf529e87a7b
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BLM TUBB6 CDCA5

2.46e-0419628373f951f7712e0aa3323676b9a4b7944d21d347c4
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO5 FLNC ACTN4

2.50e-041972835bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TUBB6 FLNC CYB5RL

2.54e-041982835d42f4fda2081ea3e9f62a00e7eea702e0d0be7d
ToppCellhealthy_donor-Lymphocytic-ILC-NK_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

MACF1 ACTN4 CXCR2

2.54e-04198283d7053a898e04478c577381085f615edaad3cdc5b
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLNC PDZRN3 CAPN6

2.54e-04198283e9f434bfd072e590fe44d518057ee5aa653038f3
ToppCellhealthy_donor-Lymphocytic-ILC|healthy_donor / Disease condition, Lineage, Cell class and subclass

MACF1 ACTN4 CXCR2

2.54e-04198283aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLNC OLFM2 CAPN6

2.54e-0419828355e583321f60c95898d93cd0d2615c6692db52ec
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TUBB6 FLNC CYB5RL

2.54e-0419828399d6a64f3410dae3019161feef20a8f06081a24b
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC PDZRN3 CAPN6

2.54e-04198283cbb63b255bdc92a557c5db1f08f7766ed9346607
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_ventral_progenitors|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.57e-04199283446cd7d960812519fe2b8e434578ef0b668c75ce
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLNC OLFM2 CAPN6

2.57e-04199283e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCellControl-NK|Control / Disease condition and Cell class

MACF1 ACTN4 CXCR2

2.57e-04199283f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

TUBB6 MACF1 CDCA5

2.57e-041992837ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLNC OLFM2 CAPN6

2.57e-04199283801887db51ac5dc5b068808ff75e3a46643398e9
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.61e-04200283cea58274efbe7f9e3c3ef9fbb768ebfb917e21d9
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells-Neuroepithelial_cell|5w / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.61e-04200283c865efaaaecccbf9c833d6c1cbe85809a3ec306d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Stem_cells|GW12 / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.61e-042002830bba93f1271dac704dddcdea8cb0f84a7ac6f42a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating-cycling_ventral_progenitors|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.61e-042002839359faa749f41aaef70b4874f20b4eed2dc12cc2
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells|5w / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.61e-042002832ee167b8bddd11fd5b1f61f87fcdf757aee3193e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Stem_cells-Neuroepithelial_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

BLM TUBB6 CDCA5

2.61e-04200283c9479452ab8c51139522383f745f02171ebbd7e2
ComputationalActin cytoskeleton binding.

FLII MACF1 FLNC ACTN4

4.21e-0730234MODULE_524
ComputationalGenes in the cancer module 419.

FLII MACF1 FLNC ACTN4

7.08e-0734234MODULE_419
ComputationalNeighborhood of MAP4K4

IPO5 SNX27 MACF1 PDE4DIP

4.42e-04172234GCM_MAP4K4
DrugCorynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

IPO5 EHBP1 MACF1 GPATCH3 PDE4DIP

3.31e-061912854811_DN
DrugNS-5

ACTN4 GALNT3

5.22e-059282CID000194622
DrugBepridil hydrochloride [74764-40-2]; Up 200; 10uM; MCF7; HT_HG-U133A

CYB5RL GPATCH3 ZZEF1 PDE4DIP

8.22e-051902842629_UP
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A

EHBP1 SNX27 EDEM3 PDE4DIP

8.39e-051912846644_DN
DrugIsoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; PC3; HT_HG-U133A

UBXN1 ZZEF1 PPP4R3A CXCR2

8.74e-051932844226_DN
DrugLetrozole [112809-51-5]; Down 200; 14uM; PC3; HT_HG-U133A

UBXN1 ZZEF1 PPP4R3A CXCR2

8.74e-051932844240_DN
Drugcalmidazolium chloride; Down 200; 5uM; MCF7; HT_HG-U133A_EA

EHBP1 EDEM3 CYB5RL PDZRN3

8.91e-05194284906_DN
Drugcolchicine; Down 200; 1uM; SKMEL5; HG-U133A

EIF5B TUBB6 GPATCH3 ZZEF1

9.09e-05195284630_DN
DrugHydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; HL60; HG-U133A

IPO5 EDEM3 MACF1 CYB5RL

9.28e-051962841775_DN
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; MCF7; HT_HG-U133A

EHBP1 EDEM3 FLNC PDE4DIP

9.28e-051962843534_DN
DrugPhenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; HL60; HG-U133A

EIF5B FLII GPATCH3 ZZEF1

9.46e-051972841602_DN
DrugMethacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A

EIF5B MACF1 PDZRN3 PPP4R3A

9.46e-051972847321_DN
DrugDyclonine hydrochloride [536-43-6]; Up 200; 12.2uM; PC3; HT_HG-U133A

EIF5B CYB5RL UBXN1 PDE4DIP

9.65e-051982847261_UP
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A

EDEM3 MACF1 PPP4R3A PDE4DIP

9.65e-051982842297_DN
DrugRonidazole [7681-76-7]; Up 200; 20uM; MCF7; HT_HG-U133A

FLNC UBXN1 CXCR2 PDE4DIP

9.65e-051982843557_UP
DrugCatechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; PC3; HT_HG-U133A

UBXN1 GALNT3 ZZEF1 CXCR2

9.84e-051992844255_DN
DrugGlutethimide, para-amino [125-84-8]; Down 200; 17.2uM; MCF7; HT_HG-U133A

IPO5 MACF1 PPP4R3A PDE4DIP

9.84e-051992847421_DN
DrugAmethopterin (R,S) [59-05-2]; Up 200; 8.8uM; PC3; HT_HG-U133A

UBXN1 ZZEF1 CXCR2 PDE4DIP

9.84e-051992846654_UP
DrugChlorthalidone [77-36-1]; Up 200; 11.8uM; HL60; HG-U133A

SNX27 FLII ACTN4 PPP4R3A

9.84e-051992841581_UP
DrugBromperidol [10457-90-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

IPO5 FLII ACTN4 PDE4DIP

9.84e-051992842872_DN
DrugNetilmicin sulfate [56931-57-2]; Down 200; 2.8uM; MCF7; HT_HG-U133A

IPO5 EIF5B GPATCH3 PDE4DIP

1.00e-042002846005_DN
DiseaseDrugs used in diabetes use measurement

MACF1 ZZEF1 PPP4R3A

1.43e-03255263EFO_0009924
DiseaseHeadache

SNX27 MACF1

1.46e-0364262HP_0002315
Diseasecortical thickness

EHBP1 FLII MACF1 ACTN4 PPP4R3A

2.57e-031113265EFO_0004840
Diseasemitochondrial DNA measurement

EDEM3 PDZRN3 CXCR2

2.93e-03328263EFO_0006312
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

EDEM3 MACF1 ZZEF1

3.92e-03364263EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasebody fat percentage

EDEM3 MACF1 ZZEF1

8.81e-03488263EFO_0007800
DiseaseCarcinoma

BLM ACTN4

9.14e-03164262C0007097

Protein segments in the cluster

PeptideGeneStartEntry
EDDEDMQDMDEMNDY

ANAPC15

81

P60006
DEWAAAMNAEFEAAE

CDCA5

231

Q96FF9
GSMGDYMAQEDDWDR

ACTN4

26

O43707
WMDDDRNDFLDDLHM

PDZRN3

511

Q9UPQ7
SWGGFSDMDFMVDES

OLFM2

316

O95897
EDEEEMWFNTDEDDM

PPP4R3A

676

Q6IN85
MWFNTDEDDMEDGEA

PPP4R3A

681

Q6IN85
LMEEWNEDLDGMEGF

FLII

896

Q13045
DWNEDIEAFEMMEKD

EDEM3

916

Q9BZQ6
DFDEQTADDWDVDMS

GPATCH3

351

Q96I76
MEDFNMESDSFEDFW

CXCR2

1

P25025
YSISMPMWEDEDDED

FLNC

141

Q14315
MMAEREEDDDTEEAW

CYB5RL

1

Q6IPT4
FEEDERWIMMEAEGE

MACF1

321

O94854
MMVDLEEDEDWANAD

IPO5

311

O00410
QDMENMSDDDGWEFV

IPO5

646

O00410
INDWDDMDDFDTSET

BLM

151

P54132
DEEMEIWGGENIEMS

GALNT3

381

Q14435
GRNTEEEEAMMQEWF

EHBP1

1106

Q8NDI1
VMSDDGEFWMSLEDF

CAPN6

316

Q9Y6Q1
VANMDESMWAEEYEG

TAS2R50

146

P59544
EEWMGALEMQDEEDR

TAGAP

176

Q8N103
EDTEDAGLDDWEAMA

EIF5B

496

O60841
GNDEDIMVDSDDDSW

PHF13

216

Q86YI8
EDDSVMMVDSYEDEW

SPRYD3

206

Q8NCJ5
HWFTGEGMDEMEFTE

TUBB6

396

Q9BUF5
WDEMQRWDTDEEGMA

SNX27

471

Q96L92
MDWLMEHEDDPDVDE

UBXN1

36

Q04323
NSEWMDECQDGMFEA

ZZEF1

1736

O43149
EQMGEAMSDGWEIEE

PDE4DIP

1061

Q5VU43