Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	CTPase activity	ENTPD7 ENTPD4	8.09e-05	6	47	2	GO:0043273
GeneOntologyMolecularFunction	UDP phosphatase activity	ENTPD7 ENTPD4	1.93e-04	9	47	2	GO:0045134
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	RIPK1 LRRK2	3.53e-04	12	47	2	GO:0004706
GeneOntologyMolecularFunction	GDP phosphatase activity	ENTPD7 ENTPD4	3.53e-04	12	47	2	GO:0004382
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH5 DNAH14	8.10e-04	18	47	2	GO:0008569
GeneOntologyMolecularFunction	nucleoside diphosphate phosphatase activity	ENTPD7 ENTPD4	1.00e-03	20	47	2	GO:0017110
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	RIPK1 LRRK2	1.83e-03	27	47	2	GO:0004709
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH5 DNAH14	1.97e-03	28	47	2	GO:0051959
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	PDE5A PTPN3 ABHD13 PPP5C RNASE13 VARS1 APTX	2.63e-03	807	47	7	GO:0016788
GeneOntologyBiologicalProcess	UDP catabolic process	ENTPD7 ENTPD4	1.52e-05	3	47	2	GO:0006256
GeneOntologyBiologicalProcess	pyrimidine nucleoside diphosphate catabolic process	ENTPD7 ENTPD4	1.52e-05	3	47	2	GO:0009140
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside diphosphate catabolic process	ENTPD7 ENTPD4	1.52e-05	3	47	2	GO:0009195
GeneOntologyBiologicalProcess	UDP metabolic process	ENTPD7 ENTPD4	1.06e-04	7	47	2	GO:0046048
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside diphosphate metabolic process	ENTPD7 ENTPD4	1.06e-04	7	47	2	GO:0009193
GeneOntologyBiologicalProcess	pyrimidine nucleoside diphosphate metabolic process	ENTPD7 ENTPD4	1.81e-04	9	47	2	GO:0009138
Domain	ZINC_FINGER_C2H2_2	ZNF814 ZC3H7A ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B APTX	2.54e-07	775	46	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF814 ZC3H7A ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B APTX	2.61e-07	777	46	12	PS00028
Domain	Znf_C2H2-like	ZNF814 ZC3H7A ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B APTX	3.38e-07	796	46	12	IPR015880
Domain	Znf_C2H2	ZNF814 ZC3H7A ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B APTX	3.81e-07	805	46	12	IPR007087
Domain	ZnF_C2H2	ZNF814 ZC3H7A ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B APTX	3.97e-07	808	46	12	SM00355
Domain	-	ZNF814 ZNF793 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B	3.47e-05	679	46	9	3.30.160.60
Domain	zf-C2H2	ZNF814 ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF682 ZNF587B	4.07e-05	693	46	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF814 ZNF793 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B	4.11e-05	694	46	9	IPR013087
Domain	GDA1_CD39	ENTPD7 ENTPD4	1.65e-04	8	46	2	PF01150
Domain	GDA1_CD39_NTPASE	ENTPD7 ENTPD4	1.65e-04	8	46	2	PS01238
Domain	GDA1_CD39_NTPase	ENTPD7 ENTPD4	1.65e-04	8	46	2	IPR000407
Domain	KRAB	ZNF814 ZNF793 ZNF418 ZNF548 ZNF682 ZNF587B	2.33e-04	358	46	6	PS50805
Domain	KRAB	ZNF814 ZNF793 ZNF418 ZNF548 ZNF682 ZNF587B	2.33e-04	358	46	6	PF01352
Domain	KRAB	ZNF814 ZNF793 ZNF418 ZNF548 ZNF682 ZNF587B	2.74e-04	369	46	6	SM00349
Domain	KRAB	ZNF814 ZNF793 ZNF418 ZNF548 ZNF682 ZNF587B	2.78e-04	370	46	6	IPR001909
Domain	-	PLA2R1 BSPH1	4.55e-04	13	46	2	2.10.10.10
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH14	5.30e-04	14	46	2	IPR024317
Domain	FN_type2_col-bd	PLA2R1 BSPH1	5.30e-04	14	46	2	IPR000562
Domain	FN2_2	PLA2R1 BSPH1	5.30e-04	14	46	2	PS51092
Domain	fn2	PLA2R1 BSPH1	5.30e-04	14	46	2	PF00040
Domain	Dynein_HC_stalk	DNAH5 DNAH14	5.30e-04	14	46	2	IPR024743
Domain	FN2_1	PLA2R1 BSPH1	5.30e-04	14	46	2	PS00023
Domain	FN2	PLA2R1 BSPH1	5.30e-04	14	46	2	SM00059
Domain	MT	DNAH5 DNAH14	5.30e-04	14	46	2	PF12777
Domain	AAA_8	DNAH5 DNAH14	5.30e-04	14	46	2	PF12780
Domain	DHC_fam	DNAH5 DNAH14	6.11e-04	15	46	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH14	6.11e-04	15	46	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH14	6.11e-04	15	46	2	PF03028
Domain	zf-C2H2_6	ZNF814 ZBTB41 ZNF418 ZNF548 ZNF682	1.01e-03	314	46	5	PF13912
Domain	RICIN	PLA2R1 GALNT17	2.15e-03	28	46	2	SM00458
Domain	RICIN_B_LECTIN	PLA2R1 GALNT17	2.15e-03	28	46	2	PS50231
Domain	Ricin_B_lectin	PLA2R1 GALNT17	2.47e-03	30	46	2	IPR000772
Domain	Kringle-like	PLA2R1 BSPH1	2.81e-03	32	46	2	IPR013806
Domain	ig	KIR2DL1 KIR2DL2 KIR3DS1	1.14e-02	190	46	3	PF00047
Domain	Immunoglobulin	KIR2DL1 KIR2DL2 KIR3DS1	1.14e-02	190	46	3	IPR013151
Pathway	REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS	ENTPD7 ENTPD4	1.39e-04	8	32	2	M27737
Pathway	REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS	ENTPD7 ENTPD4	1.39e-04	8	32	2	MM15486
Pubmed	Natural killer cells and immune surveillance.	KIR2DL1 KIR2DL2 KIR3DS1	3.79e-07	11	47	3	18830515
Pubmed	[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].	KIR2DL1 KIR2DL2 KIR3DS1	3.79e-07	11	47	3	19664392
Pubmed	Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.	KIR2DL1 KIR2DL2 KIR3DS1	5.05e-07	12	47	3	20371502
Pubmed	Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.	KIR2DL1 KIR2DL2 KIR3DS1	5.05e-07	12	47	3	19181658
Pubmed	Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.	KIR2DL1 KIR2DL2 KIR3DS1	5.05e-07	12	47	3	19936734
Pubmed	[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].	KIR2DL1 KIR2DL2 KIR3DS1	6.55e-07	13	47	3	18687225
Pubmed	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	KIR2DL1 KIR2DL2 KIR3DS1	6.55e-07	13	47	3	19934297
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DL1 KIR2DL2 KIR3DS1	6.55e-07	13	47	3	19120281
Pubmed	Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.	KIR2DL1 KIR2DL2 KIR3DS1	8.33e-07	14	47	3	19875891
Pubmed	Multiple sclerosis associates with LILRA3 deletion in Spanish patients.	KIR2DL1 KIR2DL2 KIR3DS1	8.33e-07	14	47	3	19421224
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.	KIR2DL1 KIR2DL2 KIR3DS1	8.33e-07	14	47	3	15896204
Pubmed	[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].	KIR2DL1 KIR2DL2 KIR3DS1	8.33e-07	14	47	3	19489269
Pubmed	Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.	KIR2DL1 KIR2DL2 KIR3DS1	8.33e-07	14	47	3	18945962
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	20082646
Pubmed	Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	19926642
Pubmed	Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	19850842
Pubmed	Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	20207982
Pubmed	Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	19493232
Pubmed	[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	20356536
Pubmed	Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	20643584
Pubmed	Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.	KIR2DL1 KIR2DL2 KIR3DS1	1.04e-06	15	47	3	19326408
Pubmed	Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	19897003
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	19000141
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	20670355
Pubmed	Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	19527230
Pubmed	Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	20652381
Pubmed	Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	18668235
Pubmed	Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	19279038
Pubmed	No association of KIR genes with Behcet's disease.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	17868255
Pubmed	A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	18643961
Pubmed	Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	19309280
Pubmed	Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	20331834
Pubmed	HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.	KIR2DL1 KIR2DL2 KIR3DS1	1.28e-06	16	47	3	20210919
Pubmed	Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	19032228
Pubmed	The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	20173784
Pubmed	The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	20173792
Pubmed	Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	20483367
Pubmed	[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	19968064
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	19218127
Pubmed	KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	19169284
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	20878400
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	20650299
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	19450876
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DL1 KIR2DL2 KIR3DS1	1.55e-06	17	47	3	19761533
Pubmed	Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.	RABGEF1 CRBN	1.79e-06	2	47	2	27601648
Pubmed	KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals.	KIR2DL1 KIR2DL2	1.79e-06	2	47	2	31519864
Pubmed	Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.	KIR2DL1 KIR2DL2 KIR3DS1	1.86e-06	18	47	3	19630074
Pubmed	Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.	KIR2DL1 KIR2DL2 KIR3DS1	1.86e-06	18	47	3	20519398
Pubmed	Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.	KIR2DL1 KIR2DL2 KIR3DS1	1.86e-06	18	47	3	19046302
Pubmed	Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.	KIR2DL1 KIR2DL2 KIR3DS1	1.86e-06	18	47	3	19846535
Pubmed	Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.	KIR2DL1 KIR2DL2 KIR3DS1	1.86e-06	18	47	3	20580654
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.	KIR2DL1 KIR2DL2 KIR3DS1	1.86e-06	18	47	3	20210918
Pubmed	KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.	KIR2DL1 KIR2DL2 KIR3DS1	2.21e-06	19	47	3	18571006
Pubmed	Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.	KIR2DL1 KIR2DL2 KIR3DS1	2.21e-06	19	47	3	18778326
Pubmed	Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.	KIR2DL1 KIR2DL2 KIR3DS1	2.21e-06	19	47	3	20600442
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná.	KIR2DL1 KIR2DL2 KIR3DS1	2.21e-06	19	47	3	18848853
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DL1 KIR2DL2 KIR3DS1	2.59e-06	20	47	3	20193031
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DL1 KIR2DL2 KIR3DS1	2.59e-06	20	47	3	20426625
Pubmed	Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.	KIR2DL1 KIR2DL2 KIR3DS1	3.02e-06	21	47	3	19861144
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DL1 KIR2DL2 KIR3DS1	3.50e-06	22	47	3	20492596
Pubmed	A human MAP kinase interactome.	ZC3H7A ZNF106 GTF2A1 PTPN3 ZNF142 RIPK1 ZNF418	3.87e-06	486	47	7	20936779
Pubmed	Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus.	KIR2DL2 KIR3DS1	5.36e-06	3	47	2	16698433
Pubmed	Activating KIR/HLA-I combinations as a risk factor of adult B-ALL.	KIR2DL1 KIR3DS1	5.36e-06	3	47	2	38262874
Pubmed	Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.	KIR2DL1 KIR2DL2	5.36e-06	3	47	2	15879158
Pubmed	Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.	VARS1 LRRK2	5.36e-06	3	47	2	34382495
Pubmed	[Effect of demethylation treatment on the expression of inhibitory receptor KIR gene in NK-92MI cell line].	KIR2DL1 KIR2DL2	5.36e-06	3	47	2	19549382
Pubmed	Immunogenetic characteristics of patients with autoimmune gastritis.	KIR2DL1 KIR2DL2 KIR3DS1	8.25e-06	29	47	3	20082482
Pubmed	B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression.	KIR2DL1 KIR2DL2	1.07e-05	4	47	2	20056126
Pubmed	HLA-C and KIR genes in hepatitis C virus infection.	KIR2DL1 KIR2DL2	1.07e-05	4	47	2	16571411
Pubmed	High-throughput genotyping of KIR2DL2/L3, KIR3DL1/S1, and their HLA class I ligands using real-time PCR.	KIR2DL2 KIR3DS1	1.07e-05	4	47	2	19522772
Pubmed	[Analysis of HLA-Cw, KIR2D genetic variations in 2 Chinese populations].	KIR2DL1 KIR2DL2	1.07e-05	4	47	2	18543232
Pubmed	Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general.	KIR2DL1 KIR2DL2	1.07e-05	4	47	2	25037176
Pubmed	[Distribution of immunoglobulin like receptor gene in Han population in China and the impact thereof on the HLA-identical sibling hematopoietic stem cell transplantation].	KIR2DL1 KIR2DL2	1.07e-05	4	47	2	18269867
Pubmed	Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).	KIR2DL1 KIR2DL2	1.07e-05	4	47	2	26542066
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DL1 KIR2DL2 KIR3DS1	1.47e-05	35	47	3	19683555
Pubmed	The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.	RIPK1 LRRK2	1.78e-05	5	47	2	19176810
Pubmed	KIR gene in ethnic and Mestizo populations from Mexico.	KIR2DL2 KIR3DS1	1.78e-05	5	47	2	16698429
Pubmed	Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.	KIR2DL1 KIR2DL2	1.78e-05	5	47	2	16112031
Pubmed	Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters.	KIR2DL1 KIR2DL2	1.78e-05	5	47	2	12121272
Pubmed	Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus.	KIR2DL1 KIR2DL2	1.78e-05	5	47	2	18755860
Pubmed	Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis.	KIR2DL1 KIR3DS1	1.78e-05	5	47	2	16508981
Pubmed	Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.	KIR2DL1 KIR2DL2	1.78e-05	5	47	2	18322206
Pubmed	Killer cell immunoglobulin-like receptor genotypes in Japanese patients with type 1 diabetes.	KIR2DL1 KIR3DS1	1.78e-05	5	47	2	17990989
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	ZNF106 TOPORS RPL3	1.89e-05	38	47	3	28680062
Pubmed	Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis.	KIR2DL2 KIR3DS1	2.67e-05	6	47	2	17882223
Pubmed	Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.	KIR2DL1 KIR2DL2	3.74e-05	7	47	2	14607943
Pubmed	Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.	KIR2DL1 KIR2DL2	3.74e-05	7	47	2	11169255
Pubmed	Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.	KIR2DL1 KIR3DS1	3.74e-05	7	47	2	9430220
Pubmed	KIR haplotype content at the allele level in 77 Northern Irish families.	KIR2DL2 KIR3DS1	4.98e-05	8	47	2	17200871
Pubmed	Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.	KIR2DL1 KIR2DL2	4.98e-05	8	47	2	20935224
Pubmed	A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.	KIR2DL1 KIR2DL2	4.98e-05	8	47	2	15730517
Pubmed	Human diversity in killer cell inhibitory receptor genes.	KIR2DL1 KIR3DS1	4.98e-05	8	47	2	9430221
Pubmed	NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.	KIR2DL1 KIR2DL2	4.98e-05	8	47	2	18681957
Pubmed	Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.	KIR2DL1 KIR2DL2	6.40e-05	9	47	2	7749980
Pubmed	Alternatively spliced forms of human killer inhibitory receptors.	KIR2DL2 KIR3DS1	6.40e-05	9	47	2	8662091
Pubmed	Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.	BRCA2 APTX	6.40e-05	9	47	2	19861517
Pubmed	Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.	KIR2DL1 KIR3DS1	6.40e-05	9	47	2	18340360
Pubmed	Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.	KIR2DL2 KIR3DS1	7.99e-05	10	47	2	21206914
Pubmed	Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.	KIR2DL1 KIR2DL2	7.99e-05	10	47	2	12559621
Pubmed	Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.	RIPK1 LRRK2	7.99e-05	10	47	2	29891719
Interaction	KIR2DL2 interactions	KIR2DL1 KIR2DL2 KIR3DS1	2.93e-06	13	45	3	int:KIR2DL2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF814 ZNF793 KIR2DL1 PPP5C ZNF418 ZNF548 BSPH1 ZNF587B	2.58e-05	1192	47	8	chr19q13
Cytoband	19q13.4	KIR2DL1 KIR2DL2 KIR3DS1	7.53e-05	79	47	3	19q13.4
Cytoband	19q13.43	ZNF814 ZNF418 ZNF548	1.00e-04	87	47	3	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr6p25	RIPK1 F13A1	4.05e-03	92	47	2	chr6p25
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF814 ZNF793 ZNF106 ZBTB41 ZNF142 ZNF418 ZNF548 ZNF618 ZNF682 ZNF587B	6.83e-07	718	35	10	28
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL1 KIR2DL2 KIR3DS1	5.32e-06	18	35	3	620
GeneFamily	Dyneins, axonemal	DNAH5 DNAH14	4.86e-04	17	35	2	536
ToppCell	MS-CD8-proli_CD4\|MS / Condition, Cell_class and T cell subcluster	RABGEF1 ABHD13 ZBTB41 RWDD2B ZNF587B	9.30e-07	172	46	5	0b6dd257110b3f17fa71ab18a165b091a9d5ae9a
Disease	acquired immunodeficiency syndrome (is_implicated_in)	KIR2DL1 KIR3DS1	7.77e-05	9	44	2	DOID:635 (is_implicated_in)
Disease	selenium measurement, response to dietary selenium supplementation	ZC3H7A DNAH5	4.06e-04	20	44	2	EFO_0006331, EFO_0600021
Disease	coagulation factor measurement	ZBTB41 F13A1	4.06e-04	20	44	2	EFO_0004634
Disease	Strabismus	DNAH5 ZNF618	8.60e-04	29	44	2	HP_0000486
Disease	serum IgG glycosylation measurement	GTF2A1 RPL3 CRBN CYFIP2 APTX	1.05e-03	523	44	5	EFO_0005193
Disease	urate measurement, bone density	PAPPA-AS1 ZNF618 ENTPD4 CRBN DNAH14	2.21e-03	619	44	5	EFO_0003923, EFO_0004531
Disease	diastolic blood pressure change measurement	PPP5C CRBN	2.54e-03	50	44	2	EFO_0006945
Disease	idiopathic osteonecrosis of the femoral head	FBXO25 RIPK1	2.75e-03	52	44	2	EFO_1001930
Disease	susceptibility to bacterial meningitis measurement	DNAH5 CRBN	2.75e-03	52	44	2	EFO_0008411
Disease	pulmonary hypertension (implicated_via_orthology)	PDE5A NOX1	2.96e-03	54	44	2	DOID:6432 (implicated_via_orthology)
Disease	complement factor H-related protein 1 measurement	ZBTB41 GALNT17	3.18e-03	56	44	2	EFO_0600054
Disease	protein-glutamine gamma-glutamyltransferase e measurement	PTPN3 CYFIP2	3.64e-03	60	44	2	EFO_0020690
Disease	Crohn's disease	PLA2R1 PPP5C RPL3 LRRK2	4.17e-03	441	44	4	EFO_0000384
Disease	inflammatory bowel disease	PLA2R1 PPP5C RPL3 LRRK2	4.44e-03	449	44	4	EFO_0003767

Protein segments in the cluster

Peptide	Gene	Start	Entry
WCYKNKFLSYRKISQ	ABHD13	241	Q7L211
CLKNKKHWNSFNTEY	APTX	286	Q7Z2E3
KYQKRKFHCANLTSW	CRBN	226	Q96SW2
VKWYKSHKLSQHCIR	PAPPA-AS1	31	Q5QFB9
SKCWREEYHKARQKQ	RABGEF1	36	Q9UJ41
FNMLNYRSCKNLWKS	PTPN3	286	P26045
SIWYKFQCADHNLKT	NOX1	416	Q9Y5S8
FFLLHRWCSNKKNAA	KIR2DL2	261	P43627
HRLKYQCFKSAWMYQ	ENTPD7	471	Q9NQZ7
SVKKNYRKNVAYHNW	PDE5A	601	O76074
CKYSKKHWKSRENNN	COIL	126	P38432
EACYKALTWHRKNKH	LRRK2	351	Q5S007
VNSKLTKDSVWNYHC	F13A1	361	P00488
RQLWKKLCQYHFAEK	FBXO25	266	Q8TCJ0
YSWKLVHPTDKFCNK	CYFIP2	411	Q96F07
HQYYAKVKAIWGTKC	IL20RA	106	Q9UHF4
SHSFNWRKANKYQLC	CCSER2	61	Q9H7U1
KSKARHKWCSLNKTY	BSPH1	61	Q075Z2
CSLTKNFNKDRIWKY	BSPH1	116	Q075Z2
HQWAKTLKYREACKD	BRCA2	1561	P51587
ALRKSLKCKNFQWYL	GALNT17	436	Q6IS24
TRHLQYKWNEKQKLC	DNAH14	1101	Q0VDD8
FFLLHRWCSNKKNAA	KIR2DL1	261	P43626
TSMDCFKRYNHIWQK	DNAH5	1136	Q8TE73
YRHFCNKLWNATKFA	VARS1	946	P26640
SDECKRRFYKNWHKS	RPL3	111	P39023
FRTNKPKYCKNLSWS	PKDREJ	1636	Q9NTG1
QWYKDQKKLHRKCAY	PPP5C	196	P53041
ADLHRLKYQCFKSAW	ENTPD4	481	Q9Y227
LFFLLHRWCSNKKKC	KIR3DS1	356	Q14943
KHWKNCARKLGFTQS	RIPK1	596	Q13546
NRNCYKLQKEEKTWH	PLA2R1	386	Q13018
VCQYDKIHRSKNKWK	GTF2A1	336	P52655
HAPWKAIQKFCKYSD	RNASE13	76	Q5GAN3
KSFSQKSCLNKHWRT	ZNF793	346	Q6ZN11
QYWSCVTQKHTKLAK	ZNF618	891	Q5T7W0
GEKVWQKYKATFHQC	ZBTB41	656	Q5SVQ8
KAFNWCSSLTKHKRI	ZNF682	236	O95780
WIYSHHIYNKCKRKN	RWDD2B	191	P57060
HIYNKCKRKNILEWA	RWDD2B	196	P57060
KNRKYCSAKARHSWT	ZC3H7A	726	Q8IWR0
KQKLHRCEAWGNKLY	ZNF587B	116	E7ETH6
INKYIDSKSLNWKHC	ZMYM6	961	O95789
HKFCFRCVQEWSKNK	TOPORS	121	Q9NS56
KQKLHRCEAWGNKLY	ZNF418	106	Q8TF45
CGKFFRYNSNLIKHW	ZNF548	426	Q8NEK5
DCAYSTKNRQKITWH	ZNF142	1456	P52746
KSNKSNKYSHDRYNW	ZNF106	266	Q9H2Y7
KQKLHRCEAWGNKLY	ZNF814	116	B7Z6K7