Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS12 PAPPA2 MST1 USP49 LPA MMP23B PLAT MST1L ADAM32 ADAMTSL2 PROC

5.02e-074307411GO:0004175
GeneOntologyMolecularFunctionpeptidase activity

ADAMTS12 PAPPA2 MST1 USP49 LPA MMP23B PLAT MST1L ADAM32 ADAMTSL2 PROC

2.74e-056547411GO:0008233
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS12 PAPPA2 MMP23B ADAM32 ADAMTSL2

8.34e-05120745GO:0004222
GeneOntologyMolecularFunctionserine-type endopeptidase activity

MST1 LPA PLAT MST1L PROC

7.01e-04190745GO:0004252
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS12 PAPPA2 MMP23B ADAM32 ADAMTSL2

8.82e-04200745GO:0008237
GeneOntologyMolecularFunctionserine-type peptidase activity

MST1 LPA PLAT MST1L PROC

1.03e-03207745GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

MST1 LPA PLAT MST1L PROC

1.14e-03212745GO:0017171
GeneOntologyBiologicalProcessalpha-beta T cell activation

IL12RB1 RASAL3 GIMAP5 PRKCZ FUT7 STOML2 CLEC2B

1.57e-05227737GO:0046631
GeneOntologyCellularComponentextracellular matrix

ADAMTS12 MST1 SBSPON PRG2 LPA MMP23B LAMA3 PLAT ADAMTSL2 OTOG

1.02e-046567410GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS12 MST1 SBSPON PRG2 LPA MMP23B LAMA3 PLAT ADAMTSL2 OTOG

1.04e-046587410GO:0030312
DomainKringle

MST1 LPA PLAT MST1L

4.92e-0717734IPR000001
DomainKringle_CS

MST1 LPA PLAT MST1L

4.92e-0717734IPR018056
DomainKRINGLE_2

MST1 LPA PLAT MST1L

4.92e-0717734PS50070
DomainKringle

MST1 LPA PLAT MST1L

4.92e-0717734PF00051
DomainKRINGLE_1

MST1 LPA PLAT MST1L

4.92e-0717734PS00021
DomainKR

MST1 LPA PLAT MST1L

4.92e-0717734SM00130
DomainKringle-like

MST1 LPA PLAT MST1L

7.11e-0632734IPR013806
DomainEGF-like_dom

JAG2 MEGF8 LAMA3 PLAT ADAM32 PROC OTOG

5.30e-05249737IPR000742
DomainPeptidase_S1A

MST1 LPA PLAT MST1L PROC

8.03e-05113735IPR001314
DomainTRYPSIN_DOM

MST1 LPA PLAT MST1L PROC

8.72e-05115735PS50240
DomainTryp_SPc

MST1 LPA PLAT MST1L PROC

9.47e-05117735SM00020
DomainTrypsin

MST1 LPA PLAT MST1L PROC

1.11e-04121735PF00089
DomainTrypsin_dom

MST1 LPA PLAT MST1L PROC

1.11e-04121735IPR001254
DomainPeptidase_S1_PA

MST1 LPA PLAT MST1L PROC

1.20e-04123735IPR009003
DomainPAN_AP

MST1 MST1L

1.50e-045732SM00473
DomainK_chnl_volt-dep_KCNQ

KCNQ5 KCNQ4

1.50e-045732IPR003937
DomainK_chnl_volt-dep_KCNQ_C

KCNQ5 KCNQ4

1.50e-045732IPR013821
DomainKCNQ_channel

KCNQ5 KCNQ4

1.50e-045732PF03520
DomainPSI

MEGF8 SEMA3G PLXNA1

2.62e-0432733PF01437
DomainPlexin_repeat

MEGF8 SEMA3G PLXNA1

2.62e-0432733IPR002165
DomainMetalloPept_cat_dom

ADAMTS12 PAPPA2 MMP23B ADAM32

2.85e-0481734IPR024079
Domain-

ADAMTS12 PAPPA2 MMP23B ADAM32

2.85e-04817343.40.390.10
DomainVG_K_chnl

KCNG2 KCNQ5 KCNQ4

2.87e-0433733IPR028325
DomainPAN

MST1 MST1L

3.12e-047732PS50948
DomainAPC_su10/DOC_dom

MYCBP2 CUL9

3.12e-047732IPR004939
DomainPan_app

MST1 MST1L

3.12e-047732IPR003609
DomainDOC

MYCBP2 CUL9

3.12e-047732PS51284
DomainCullin_CS

CUL1 CUL9

3.12e-047732IPR016157
DomainPAN_1

MST1 MST1L

3.12e-047732PF00024
DomainAPC10

MYCBP2 CUL9

3.12e-047732SM01337
DomainANAPC10

MYCBP2 CUL9

3.12e-047732PF03256
DomainEGF_3

JAG2 MEGF8 PLAT ADAM32 PROC OTOG

3.14e-04235736PS50026
DomainEGF

JAG2 MEGF8 LAMA3 PLAT ADAM32 PROC

3.14e-04235736SM00181
DomainCullin_Nedd8

CUL1 CUL9

4.16e-048732PF10557
DomainCullin_Nedd8

CUL1 CUL9

4.16e-048732SM00884
DomainCullin_neddylation_domain

CUL1 CUL9

4.16e-048732IPR019559
DomainEGF_1

JAG2 MEGF8 LAMA3 PLAT ADAM32 PROC

4.84e-04255736PS00022
DomainCullin_homology

CUL1 CUL9

5.33e-049732IPR016158
DomainEGF-like_CS

JAG2 MEGF8 LAMA3 PLAT ADAM32 PROC

5.47e-04261736IPR013032
DomainEGF_2

JAG2 MEGF8 LAMA3 PLAT ADAM32 PROC

5.93e-04265736PS01186
DomainCullin

CUL1 CUL9

6.64e-0410732PF00888
DomainCULLIN_2

CUL1 CUL9

6.64e-0410732PS50069
DomainCullin_N

CUL1 CUL9

6.64e-0410732IPR001373
DomainCULLIN_1

CUL1 CUL9

6.64e-0410732PS01256
DomainPSI

MEGF8 SEMA3G PLXNA1

6.76e-0444733IPR016201
DomainPSI

MEGF8 SEMA3G PLXNA1

7.71e-0446733SM00423
DomainIon_trans_dom

CACNA1F KCNG2 KCNQ5 KCNQ4

1.04e-03114734IPR005821
DomainIon_trans

CACNA1F KCNG2 KCNQ5 KCNQ4

1.04e-03114734PF00520
DomainTSP_1

ADAMTS12 SBSPON ADAMTSL2

1.92e-0363733PF00090
DomainTSP1

ADAMTS12 SBSPON ADAMTSL2

2.10e-0365733SM00209
DomainTSP1_rpt

ADAMTS12 SBSPON ADAMTSL2

2.10e-0365733IPR000884
DomainTSP1

ADAMTS12 SBSPON ADAMTSL2

2.10e-0365733PS50092
DomainVWC_out

JAG2 OTOG

2.47e-0319732SM00215
DomainPLAC

ADAMTS12 ADAMTSL2

2.47e-0319732PS50900
DomainPLAC

ADAMTS12 ADAMTSL2

2.47e-0319732IPR010909
DomainLIM

MICALL1 LIMK2 LHX6

2.49e-0369733PF00412
Domain-

MICALL1 LIMK2 LHX6

2.60e-03707332.10.110.10
DomainZnf_LIM

MICALL1 LIMK2 LHX6

2.71e-0371733IPR001781
DomainLIM_DOMAIN_1

MICALL1 LIMK2 LHX6

2.71e-0371733PS00478
DomainLIM_DOMAIN_2

MICALL1 LIMK2 LHX6

2.71e-0371733PS50023
DomainLIM

MICALL1 LIMK2 LHX6

2.71e-0371733SM00132
DomainADAM_spacer1

ADAMTS12 ADAMTSL2

3.61e-0323732IPR010294
DomainADAM_spacer1

ADAMTS12 ADAMTSL2

3.61e-0323732PF05986
DomainIQ

IQCF5 XKR7 IQCF1

3.93e-0381733SM00015
DomainPeptidase_M12B_ADAM-TS

ADAMTS12 ADAMTSL2

3.93e-0324732IPR013273
DomainIQ_motif_EF-hand-BS

IQCF5 XKR7 IQCF1

5.28e-0390733IPR000048
DomainEGF_LAM_2

MEGF8 LAMA3

6.11e-0330732PS50027
DomainEGF_LAM_1

MEGF8 LAMA3

6.11e-0330732PS01248
DomainEGF_Ca-bd_CS

JAG2 MEGF8 PROC

6.49e-0397733IPR018097
DomainSema

SEMA3G PLXNA1

6.51e-0331732SM00630
PathwayPID_AMB2_NEUTROPHILS_PATHWAY

MST1 LPA PLAT PRKCZ

1.89e-0541554M159
PathwayREACTOME_SIGNALING_BY_MST1

MST1 MST1L

2.22e-046552MM15492
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS12 SBSPON NUS1 CHSY1 ADAMTSL2

2.32e-04143555M27275
PathwayBIOCARTA_MSP_PATHWAY

MST1 MST1L

3.10e-047552MM1580
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

FFAR1 PLCB3

4.12e-048552M27356
PathwayWP_MIR302367_PROMOTING_CARDIOMYOCYTE_PROLIFERATION

MST1 MST1L

4.12e-048552MM15986
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

FFAR1 PLCB3

4.12e-048552MM15100
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 SBSPON ADAMTSL2

4.65e-0439553M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 SBSPON ADAMTSL2

4.65e-0439553MM15165
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNG2 KCNQ5 KCNQ4

5.39e-0441553MM14546
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNG2 KCNQ5 KCNQ4

6.21e-0443553M1056
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

FFAR1 PLCB3

8.04e-0411552M27317
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

FFAR1 PLCB3

8.04e-0411552MM15035
PathwayWP_1P36_COPY_NUMBER_VARIATION_SYNDROME

MMP23B PEX2 C1orf159 PRKCZ

9.43e-04112554M48072
PathwayBIOCARTA_FIBRINOLYSIS_PATHWAY

LPA PLAT

9.62e-0412552MM1398
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MICALL1 LIMK2 INTS12 KCNQ5 MEGF8 MYCBP2 WEE1 PRMT5 ARFGAP1 LYST DOP1A OTOG

3.56e-07861761236931259
Pubmed

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.

MST1 MST1L

4.71e-06276229760744
Pubmed

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.

KCNQ5 KCNQ4

4.71e-06276218536747
Pubmed

Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.

MST1 MST1L

4.71e-0627628393443
Pubmed

Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.

PRG2 PRKCZ

4.71e-06276211222751
Pubmed

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.

MST1 MST1L

4.71e-06276227609031
Pubmed

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.

MST1 MST1L

4.71e-06276224980820
Pubmed

Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP2) Affinity and Signaling Sensitivities in Smooth Muscle Cells.

KCNQ5 KCNQ4

4.71e-06276231871302
Pubmed

Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.

MST1 MST1L

4.71e-06276231206688
Pubmed

Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.

MST1 MST1L

4.71e-06276210728827
Pubmed

Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.

MST1 MST1L

4.71e-06276216961763
Pubmed

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.

MST1 MST1L

4.71e-06276239253972
Pubmed

Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.

MST1 MST1L

4.71e-06276232017081
Pubmed

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.

MST1 MST1L

4.71e-06276230708325
Pubmed

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

MST1 MST1L

4.71e-06276224409221
Pubmed

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.

MST1 MST1L

4.71e-06276227696525
Pubmed

Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.

MST1 MST1L

4.71e-0627628340069
Pubmed

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.

MST1 MST1L

4.71e-0627629486989
Pubmed

Inactivation as a new regulatory mechanism for neuronal Kv7 channels.

KCNQ5 KCNQ4

4.71e-06276217237198
Pubmed

Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.

KCNQ5 KCNQ4

4.71e-06276219389803
Pubmed

Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.

MST1 MST1L

4.71e-06276233887258
Pubmed

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.

KCNQ5 KCNQ4

4.71e-06276223408425
Pubmed

HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.

MST1 MST1L

4.71e-06276225938541
Pubmed

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

FFAR1 PRKCZ

1.41e-05376222820510
Pubmed

Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.

LPA PLAT

1.41e-05376216818777
Pubmed

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.

MST1 MST1L

1.41e-05376210225971
Pubmed

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.

MST1 MST1L

1.41e-05376238430683
Pubmed

Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.

MST1 MST1L

1.41e-05376212538524
Pubmed

Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.

LPA PLAT

1.41e-05376224612416
Pubmed

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.

MST1 MST1L

1.41e-05376219339990
Pubmed

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.

MST1 MST1L

1.41e-05376226698664
Pubmed

Feedback-regulated transcriptional repression of FBXO31 by c-Myc triggers ovarian cancer tumorigenesis.

CUL1 FBXO31

1.41e-05376234706096
Pubmed

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.

MST1 MST1L

1.41e-05376230063115
Pubmed

Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.

MST1 MST1L

1.41e-05376227218122
Pubmed

Limk2 mediates semaphorin signalling in cortical interneurons migrating through the subpallium.

LIMK2 LHX6

1.41e-05376223519094
Pubmed

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

LPA PLAT

1.41e-05376215630096
Pubmed

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.

MST1 MST1L

1.41e-05376217395874
Pubmed

Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation.

LPA PLAT

1.41e-05376217717150
Pubmed

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

MST1 MST1L

1.41e-05376224852423
Pubmed

Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.

KCNQ5 KCNQ4

1.41e-05376218786918
Pubmed

Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.

KCNQ5 KCNQ4

1.41e-05376224297175
Pubmed

Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.

LPA PLAT

1.41e-05376216330749
Pubmed

Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes.

LPA PLAT

1.41e-05376210559390
Pubmed

Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.

KCNQ5 KCNQ4

1.41e-05376217519950
Pubmed

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.

MST1 MST1L

1.41e-05376227496379
Pubmed

Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.

MST1 MST1L

1.41e-05376212804176
Pubmed

Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.

MST1 MST1L

1.41e-05376212606483
Pubmed

Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.

KCNQ5 KCNQ4

1.41e-05376226969140
Pubmed

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

LPA PLAT

1.41e-05376224196407
Pubmed

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.

MST1 MST1L

1.41e-05376236623453
Pubmed

Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.

MST1 MST1L

1.41e-05376237184367
Pubmed

CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.

MST1 MST1L

1.41e-05376238288506
Pubmed

The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.

MST1 MST1L

1.41e-0537628545120
Pubmed

Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.

MST1 MST1L

1.41e-05376225049204
Pubmed

The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.

LPA PLAT

1.41e-05376214988509
Pubmed

Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.

MST1 MST1L

1.41e-0537621832957
Pubmed

Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.

MST1 MST1L

1.41e-05376225183307
Pubmed

MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.

MST1 MST1L

1.41e-05376235525373
Pubmed

MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.

MST1 MST1L

1.41e-05376227510910
Pubmed

Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior.

LPA PLAT

1.41e-05376212524546
Pubmed

Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.

MST1 MST1L

1.41e-05376231976559
Pubmed

Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.

MST1 MST1L

1.41e-05376232468668
Pubmed

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus.

LPA PLAT

1.41e-0537628987777
Pubmed

Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.

MST1 MST1L

1.41e-05376229127009
Pubmed

The hippocampal laminin matrix is dynamic and critical for neuronal survival.

LPA PLAT

1.41e-05376212857855
Pubmed

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.

MST1 MST1L

1.41e-05376227465533
Pubmed

Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5.

LAMA3 PLAT

1.41e-05376210956663
Pubmed

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

MST1 MST1L

1.41e-05376230771091
Pubmed

Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injury.

LPA PLAT

1.41e-05376219220707
Pubmed

MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.

MST1 MST1L

1.41e-05376234967918
Pubmed

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.

MST1 MST1L

1.41e-05376238898027
Pubmed

WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.

MST1 MST1L

1.41e-05376232045478
Pubmed

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.

MST1 MST1L

1.41e-05376227940445
Pubmed

Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior.

LPA PLAT

1.41e-05376215522965
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MICALL1 JAG2 KLF10 MEGF8 MYCBP2 ZBTB4 CHSY1 CUL9 ZBTB42 LYST PLXNA1

2.75e-051105761135748872
Pubmed

Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice.

LPA PLAT

2.82e-05476221931850
Pubmed

Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.

LPA PLAT

2.82e-05476219210287
Pubmed

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.

MST1 MST1L

2.82e-05476221078906
Pubmed

MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.

MST1 MST1L

2.82e-05476236618429
Pubmed

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.

LPA PLAT

2.82e-05476212070304
Pubmed

Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.

MST1 MST1L

2.82e-05476235715527
Pubmed

Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.

LPA PLAT

2.82e-05476215486301
Pubmed

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.

MST1 MST1L

2.82e-05476225074980
Pubmed

OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.

MST1 MST1L

2.82e-05476227825852
Pubmed

FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex.

CUL1 FBXO31

2.82e-05476216357137
Pubmed

Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.

LPA PLAT

2.82e-05476217301181
Pubmed

MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.

MST1 MST1L

2.82e-05476228527887
Pubmed

Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injury.

LPA PLAT

2.82e-05476218042398
Pubmed

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.

MST1 MST1L

2.82e-05476225133611
Pubmed

LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.

MST1 MST1L

2.82e-05476232627655
Pubmed

Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.

MST1 MST1L

2.82e-05476234515499
Pubmed

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

LPA PLAT

2.82e-05476216763560
Pubmed

Tissue plasminogen activator and plasminogen are critical for osmotic homeostasis by regulating vasopressin secretion.

LPA PLAT

2.82e-05476220175210
Pubmed

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.

MST1 MST1L

2.82e-05476222412158
Pubmed

Functional role of Mst1/Mst2 in embryonic stem cell differentiation.

MST1 MST1L

2.82e-05476224224013
Pubmed

Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

MST1 MST1L

2.82e-05476226903296
Pubmed

Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.

MST1 MST1L

2.82e-05476223527007
Pubmed

Plasmin is essential in preventing periodontitis in mice.

LPA PLAT

2.82e-05476221704601
Pubmed

A cell-intrinsic role for Mst1 in regulating thymocyte egress.

MST1 MST1L

2.82e-05476219692642
Pubmed

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.

MST1 MST1L

2.82e-05476228480597
Cytoband3p21.2

IQCF5 IQCF1

4.54e-04197623p21.2
Cytoband9p24.1

MLANA PLPP6

1.47e-03347629p24.1
CytobandEnsembl 112 genes in cytogenetic band chr3p21

IQCF5 MST1 IQCF1 SEMA3G

1.91e-03316764chr3p21
GeneFamilyPotassium voltage-gated channels

KCNG2 KCNQ5 KCNQ4

1.94e-0440513274
GeneFamilyCullins

CUL1 CUL9

2.16e-0485121032
CoexpressionNABA_MATRISOME

ADAMTS12 PAPPA2 MST1 MEGF8 SBSPON PRG2 LPA MMP23B LAMA3 PLAT MST1L SEMA3G ADAM32 PLXNA1 ADAMTSL2 CLEC2B OTOG

2.92e-0910267417M5889
CoexpressionNABA_MATRISOME

ADAMTS12 PAPPA2 MST1 MEGF8 SBSPON PRG2 LPA MMP23B LAMA3 PLAT MST1L SEMA3G ADAM32 PLXNA1 ADAMTSL2 OTOG

1.68e-0810087416MM17056
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS12 PAPPA2 MST1 MEGF8 LPA MMP23B PLAT MST1L SEMA3G ADAM32 PLXNA1 ADAMTSL2 CLEC2B

1.66e-077517413M5885
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS12 PAPPA2 MST1 MEGF8 LPA MMP23B PLAT MST1L SEMA3G ADAM32 PLXNA1 ADAMTSL2

1.01e-067387412MM17058
CoexpressionNABA_ECM_REGULATORS

ADAMTS12 PAPPA2 LPA MMP23B PLAT ADAM32 ADAMTSL2

5.00e-06238747M3468
CoexpressionNABA_ECM_REGULATORS

ADAMTS12 PAPPA2 LPA MMP23B PLAT ADAM32 ADAMTSL2

5.58e-06242747MM17062
CoexpressionCAIRO_LIVER_DEVELOPMENT_DN

MST1 PRG2 LPA MST1L LYST PROC

5.96e-05239746MM1274
ToppCellfacs-Lung-24m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 KCNQ5 GIMAP5 PRMT5 CHSY1 C1orf159

2.93e-0715776634eb1cbdb023d3e23b2e1695c9c327c21ef1c870
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ5 GIMAP5 PRMT5 CHSY1 C1orf159 PTPN18

2.93e-07157766071f10d749b590b75a07ab3c7b00956dc7cda4da
ToppCellfacs-Lung-24m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 KCNQ5 GIMAP5 PRMT5 CHSY1 C1orf159

2.93e-07157766fc0c222124f59c94d60335f849554eaa4062f8c7
ToppCellfacs-Lung-24m-Hematologic-Lymphocytic_NK_ILC|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 KCNQ5 GIMAP5 PRMT5 CHSY1 C1orf159

2.93e-0715776640b08ace1d9ea7951886f5fed76ac57e9175436b
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ5 GIMAP5 PRMT5 CHSY1 C1orf159 PTPN18

2.93e-07157766af110085dad5d26b0b7068a78f104ba784fa8564
ToppCell11.5-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

JAG2 FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

1.07e-06196766509ddea8d6e1d0b832f69490ab8a736af4ca19a8
ToppCell11.5-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

JAG2 FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

1.07e-06196766e7d55933e23599122e20498548abf5b30fc25c8f
ToppCell18-Distal-Endothelial-Endothelial|Distal / Age, Tissue, Lineage and Cell class

JAG2 FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

1.14e-06198766efd3af3c0b4ab29605331ecdcb7a52cba38e6028
ToppCell18-Distal-Endothelial|Distal / Age, Tissue, Lineage and Cell class

JAG2 FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

1.14e-06198766ee657a84928d54eb7a9a66c7acb19a7c119d6423
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 FRY EXOC3L1 SEMA3G RGS3 ADAMTSL2

1.17e-061997660602e2b2aa56d106da63bd342a38bef437b4d496
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 RASAL3 GIMAP5 CHSY1 PTPN18

5.88e-061507651f83e3be3f94aefe991a3ccd292c2d11ddef858e
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 RASAL3 GIMAP5 CHSY1 PTPN18

5.88e-06150765cd666db614bc1b43d71e8eb7bf38cae4d580be80
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 RASAL3 GIMAP5 CHSY1 PTPN18

5.88e-06150765f6ed3e7b36014d1e429b255b0027d89865e1ac07
ToppCellfacs-GAT-Fat-18m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASAL3 KCNQ5 GIMAP5 CHSY1 PTPN18

7.81e-06159765796e63f6052189106359a4e01eae3e466bf1d593
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 RASAL3 GIMAP5 CHSY1 PTPN18

9.91e-06167765895844a45721988788d01120eb880603ba3ca139
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 RASAL3 GIMAP5 CHSY1 PTPN18

9.91e-06167765cde82e3dacf347226a78873b166608b7851b34d4
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB1 RASAL3 GIMAP5 CHSY1 PTPN18

9.91e-061677656f54a699d9266c5f09ed890a11b403a6c8476fc1
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1F IL12RB1 RASAL3 GIMAP5 LYST

1.02e-0516876519d2c763b50e7168dfa7449fc407489b055526c2
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1F IL12RB1 RASAL3 GIMAP5 LYST

1.02e-05168765fa198bd53b2d640d9a8684783bf5ca23314caae2
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PRKCZ PTPN18

1.28e-05176765e2b4be7d4f31a78d7862c0fd629dd9cc84589193
ToppCelldroplet-Bladder-nan-24m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASAL3 GIMAP5 PRG2 FUT7 PTPN18

1.28e-051767650089b50d607f4d2f18639fab0f3fc779227baa7a
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PRKCZ PTPN18

1.28e-05176765299075e65ca86564e1c0b06058bd4371a60a3bcd
ToppCellNS-moderate-d_16-33-Myeloid-pDC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNG2 ICOSLG MMP23B FUT7 PROC

1.42e-05180765144818e69613296cde43f29cb8c20899c670b319
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1F SBSPON LAMA3 HEATR5A PRKCZ

1.46e-05181765b45b11428d13950369347e051d4d517efb2bd4fd
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRG2 NUS1 LAMA3 SEMA3G RGS3

1.46e-05181765709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|390C / Donor, Lineage, Cell class and subclass (all cells)

MST1 FLYWCH1 FBXO31 ZBTB42 PLPP6

1.67e-05186765064b6047215597465bb51a8a1547ef5a226552f9
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MST1 FLYWCH1 FBXO31 ZBTB42 PLPP6

1.75e-051887652c4e791df69a9df29922f9117e5cac7787c129ce
ToppCellPCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

JAG2 EXOC3L1 SEMA3G LHX6 CLEC2B

1.85e-051907659a2244c3973aee7270646bf00db7727edb9decc5
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

JAG2 EXOC3L1 SEMA3G LHX6 CLEC2B

1.99e-051937654f38aae346ea3b4258744e9dc1e5aeb4fea13d06
ToppCell15-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

JAG2 GIMAP5 EXOC3L1 SEMA3G LHX6

2.04e-05194765ac0e48b0c09a7f57d30dff321b0c30a4c5e16ad9
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

JAG2 EXOC3L1 SEMA3G LHX6 CLEC2B

2.04e-051947658c88a0ddd61ad900426e312ca4ab13061c0380b8
ToppCell15-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

JAG2 GIMAP5 EXOC3L1 SEMA3G LHX6

2.04e-05194765f3851337a2d17f4acef2cd812a766eb0b503748b
ToppCell10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

JAG2 XKR7 EXOC3L1 SEMA3G LHX6

2.04e-051947658a4be91414a2e69dd410aa75791f16008204c9a1
ToppCellPCW_05-06-Endothelial-Endothelial_mature|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

JAG2 EXOC3L1 SEMA3G LHX6 CLEC2B

2.09e-0519576554fde2cfa51ab3a2d48d2426494ca6f0ce77f725
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 PAPPA2 SBSPON MMP23B PLAT

2.09e-05195765d32716a12014522492becbde1088dc1106308490
ToppCell11.5-Distal-Endothelial|Distal / Age, Tissue, Lineage and Cell class

FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

2.09e-05195765efdede0f476883ffddd247fa7bc6449e7932613e
ToppCell11.5-Distal-Endothelial-Endothelial|Distal / Age, Tissue, Lineage and Cell class

FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

2.09e-051957651e9b52b201ab6c78f536609e2afe1d680c71a6e7
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON MMP23B LAMA3 PRKCZ PLXNA1

2.09e-0519576568f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCellAT1_cells|World / lung cells shred on cell class, cell subclass, sample id

SBSPON MMP23B LAMA3 PRKCZ PLXNA1

2.09e-05195765792d6a49b0a875a00569071183d195287a9925c5
ToppCellPCW_07-8.5-Endothelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

JAG2 EXOC3L1 SEMA3G LHX6 CLEC2B

2.09e-05195765f2cc94d5e1652203ca38bea57f37d3deec73ef04
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON MMP23B LAMA3 PRKCZ PLXNA1

2.09e-051957652a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 PAPPA2 SBSPON MMP23B PLAT

2.09e-05195765b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-Early_cap|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

JAG2 EXOC3L1 SEMA3G LHX6 CLEC2B

2.14e-051967650f00aac6dac699507ce336020b2e96fd192de0be
ToppCell15-Distal-Endothelial-Endothelial|Distal / Age, Tissue, Lineage and Cell class

FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

2.14e-05196765fda2dd3895bf6ae39fcce2050e4878750f5f5b71
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON MMP23B LAMA3 PRKCZ PLXNA1

2.14e-05196765eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell15-Distal-Endothelial|Distal / Age, Tissue, Lineage and Cell class

FRY GIMAP5 EXOC3L1 LHX6 CLEC2B

2.14e-0519676503245aca5cb97fd5c3f8a986efff7131ccd40e34
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 INTS12 KCNQ5 SBSPON LAMA3

2.20e-05197765f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 EXOC3L1 PLAT SEMA3G ADAMTSL2

2.20e-05197765c29ed0e706999d4c2b93e6e3bf46c42aeceb4813
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CUL1 BPTF MYCBP2 ZBTB4 PTPN18

2.25e-0519876576d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 EXOC3L1 SEMA3G RGS3 ADAMTSL2

2.30e-05199765463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CACNA1F SBSPON LAMA3 HEATR5A PLXNA1

2.36e-05200765ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 CHSY1 PLAT SEMA3G LHX6

2.36e-05200765cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-7|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

ADAMTS12 CHSY1 ZC3H11B RGS3

6.64e-05127764c4809d8502f460370f824719d69b13b400a2b202
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

GIMAP5 LAMA3 EXOC3L1 ZBTB42

7.94e-0513376429b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)|Thalamus / BrainAtlas - Mouse McCarroll V32

GIMAP5 LAMA3 SEMA3G ZBTB42

1.02e-0414276458bfff3284ae21150e4619511bd58622c16c5dde
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--|Thalamus / BrainAtlas - Mouse McCarroll V32

GIMAP5 LAMA3 SEMA3G ZBTB42

1.02e-041427645fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-|Thalamus / BrainAtlas - Mouse McCarroll V32

GIMAP5 LAMA3 SEMA3G ZBTB42

1.02e-0414276416f9945e835c3506b12d904778560d065a50f059
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CACNA1F WEE1 ADAM32 ADAMTSL2

1.11e-04145764b17699f7f98d2361a4d26c26f52db05e7ff69dff
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB1 RASAL3 PROC OTOG

1.14e-04146764a5c84ad44d6ffb25028a4fd5454fd5de81b16a5e
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB1 RASAL3 PROC OTOG

1.14e-041467648133037881c15e75637fc616091a7055488dd5fc
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB1 RASAL3 PROC OTOG

1.30e-04151764b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCellfacs-GAT-Fat-3m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 CHSY1

1.30e-041517643d07b79ecbcfad13116f0f2b039bd181a7ffe853
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_CCDC184|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNG2 LAMA3 EXOC3L1 PLAT

1.43e-041557640d7410092b2e8bab7aa9181b9780b9331e483b17
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASL10A ARL14EPL SEMA3G ADAMTSL2

1.54e-04158764f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASL10A ARL14EPL SEMA3G ADAMTSL2

1.54e-041587648c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellsevere_COVID-19-pDC|World / disease group, cell group and cell class (v2)

CACNA1F FUT7 PLXNA1 PROC

1.58e-04159764e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCellsevere_COVID-19-pDC|severe_COVID-19 / disease group, cell group and cell class (v2)

CACNA1F FUT7 PLXNA1 PROC

1.58e-04159764ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCelldroplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 KCNQ5 GIMAP5 CHSY1

1.70e-04162764ccba6d8d644fe56060ad388ec3a062b7e3b9f086
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MLANA AMHR2 LAMA3 TMEM213

1.70e-0416276434b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCellMild-Lymphoid-NK-innate_T|Mild / Condition, Lineage, Cell class and cell subclass

USP49 RASAL3 ZC3H11B PLAT

1.70e-04162764bd218e41b2eadc3bba4c7ac3e34a014f6ad8b1bf
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNQ4 NUS1 PTPN18 ZBTB42

1.70e-0416276480619a93c57fe16daf91dc571874ef9ac888953d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 WEE1 LAMA3 LYST

1.70e-04162764373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MLANA AMHR2 LAMA3 TMEM213

1.74e-0416376456b8668dbf06faa6866ec71f29b92907b73f074d
ToppCelldroplet-Kidney-nan-24m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PTPN18

1.74e-04163764d18fee517e0daed51f89703f94f218567c83cb03
ToppCelldroplet-Kidney-nan-24m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PTPN18

1.74e-04163764f4a6e28ad3c1fcbf62ed9b2bf09f65d2ab0b31d1
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 CHSY1

1.74e-04163764a0315855c354e830e109d41bd6e3396488aa8de9
ToppCelldroplet-Fat-Scat-18m-Lymphocytic-T_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PTPN18

1.74e-04163764b1a38985d0560dbc6ca66f711d52a208303860ca
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 CHSY1

1.78e-04164764a59078c8f88e416e940c9b15151ce7de1bbe987e
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL12RB1 RASAL3 MCF2L2 CLEC2B

1.78e-0416476474bf6080abd9191e3db8ee892fce84f1dcc4b775
ToppCelldroplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 GIMAP5 CHSY1 PTPN18

1.78e-04164764c2cd4e4b88cc1b80a9494f59d31339007ff824c1
ToppCelldroplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 GIMAP5 CHSY1 PTPN18

1.78e-04164764d4d08353c7322f97ea07dd583b08661d635fff20
ToppCelldroplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASAL3 GIMAP5 CHSY1 PTPN18

1.82e-0416576488745bf7ecb0f7fc93077cea20171d40535dd56b
ToppCellLPS-antiTNF-Endothelial-Mes-Like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCNQ4 LHX6 PLPP6 ADAMTSL2

1.86e-041667643b750d4023a0a09d86113aae5a97d84391f7b482
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRY KCNQ4 LPA PTPN18

1.95e-041687648072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellNS-moderate-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNG2 MMP23B FUT7 PROC

1.95e-04168764d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCellfacs-Liver-Non-hepatocytes-24m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASAL3 GIMAP5 CHSY1 PTPN18

1.95e-041687641254c66f0cd53ef3b913933c0b0648d091da07e9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 LIMK2 ZBTB42 RGS3

2.00e-04169764c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON PRKCZ FUT7 PTPN18

2.04e-041707642b5b1f8d13b9806b76b44a53f47a23dd9ff09808
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON PRKCZ FUT7 PTPN18

2.04e-0417076443c48267d8291c88263148a36fbb63c27f0e4f1c
ToppCellfacs-GAT-Fat-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQCF5 RASAL3 GIMAP5 PTPN18

2.14e-04172764a9f0ccaca0d83bfec79e3251e346a165c34c242b
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PRKCZ

2.14e-041727644d04df9776394ea156ed5822f92ae74fdefbaa3d
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ADAMTS12 IL12RB1 GIMAP5 SBSPON

2.14e-04172764c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB1 RASAL3 GIMAP5 PTPN18

2.14e-041727644bdcf1ae2a1cfba0272c54072e37fb7958904321
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PRKCZ

2.14e-041727643acf35b774ebc0f9e96299d0bd3e9d03bbf6b90c
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 RASL10A FRY SEMA3G

2.18e-04173764ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

AMHR2 FRY PRG2 PLAT

2.18e-041737641e4afa020fae682521335b440ccd33c16f37156f
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 RASL10A FRY SEMA3G

2.18e-0417376422200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCellAT1_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

WEE1 LAMA3 PRKCZ PLXNA1

2.18e-04173764b29816427428c7053017477f59b828bf1357f3b2
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PTPN18

2.23e-04174764986e591d3d46009e53548dfa1f2126cf31063ef4
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB1 RASAL3 GIMAP5 PTPN18

2.23e-04174764785be49a2dbbb1dff0fbced1b48b942c2f4a508d
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; HL60; HT_HG-U133A

MICALL1 IL12RB1 ICOSLG LIMK2 PLCB3 PRKCZ DOP1A

3.72e-061987472730_DN
DiseaseThromboembolism

LPA PLAT PROC

3.15e-0612733C0040038
DiseaseDeep Vein Thrombosis

LPA PLAT PROC

1.87e-0521733C0149871
DiseaseVenous Thrombosis

LPA PLAT PROC

1.87e-0521733C0042487
DiseaseVenous Thromboembolism

PLAT PROC

1.67e-048732C1861172
Diseaseantiphospholipid syndrome (is_implicated_in)

PLAT PROC

1.67e-048732DOID:2988 (is_implicated_in)
Diseasedisseminated intravascular coagulation (is_marker_for)

PLAT PROC

2.68e-0410732DOID:11247 (is_marker_for)
Diseaselong QT syndrome (implicated_via_orthology)

KCNQ5 KCNQ4

2.68e-0410732DOID:2843 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ5 KCNQ4

4.63e-0413732DOID:0112202 (implicated_via_orthology)
Diseaseemployment status

PRG2 ADAM32

6.21e-0415732EFO_0005241
DiseaseLiver Cirrhosis, Experimental

FRY LIMK2 ACBD4 ZBTB4 CHSY1 PLAT PTPN18 RGS3

6.47e-04774738C0023893
Diseasehair colour measurement

ADAMTS12 MLANA PLAT LYST RGS3 PLXNA1 PROC

8.19e-04615737EFO_0007822
Diseasesexual dimorphism measurement

PAPPA2 USP49 BPTF LPA ZBTB4 CHSY1 ZC3H11B PLCB3 PROC

1.59e-031106739EFO_0021796
Diseaseinflammatory bowel disease (implicated_via_orthology)

MST1 MST1L

1.75e-0325732DOID:0050589 (implicated_via_orthology)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

LPA ZC3H11B PLCB3

2.33e-03106733EFO_0008317, EFO_0008596
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

BPTF LPA ZC3H11B PLCB3

2.34e-03224734EFO_0004530, EFO_0008317

Protein segments in the cluster

PeptideGeneStartEntry
CREIENGRKRCERYW

PTPN18

131

Q99952
QSVCERTGRFCRDFW

EXOC3L1

561

Q86VI1
GPECRCNRRWVYDAI

ARL14EPL

121

P0DKL9
WGQFEHYRRACRRCR

ACBD4

231

Q8NC06
TYGIWICLECSGRHR

ARFGAP1

36

Q8N6T3
DYVARWFEECCRRTL

DOP1A

436

Q5JWR5
CGRDRNNKYVFCGWR

ADAM32

531

Q8TC27
DRCQNWYHGRCVGIL

BPTF

2886

Q12830
STTCGLGAYWRRVEC

ADAMTS12

1326

P58397
RAIRCLYSRCCFGIW

AMHR2

51

Q16671
RCFSCRSAAERDRWI

RASAL3

271

Q86YV0
RRLYSGPWRSCEEVC

RGS3

66

P49796
VRIIQAYWRCRSCAS

IQCF1

151

Q8N6M8
AYWRCRSCASRGFIK

IQCF1

156

Q8N6M8
NDPRLVWYCARCTRQ

INTS12

201

Q96CB8
RCRRAVKSNACYWAV

CACNA1F

521

O60840
LLIGCWYCRRRNGYR

MLANA

41

Q16655
DRCCTGYNQRRWRPA

LAMA3

331

Q16787
CVWCNGEEYRGAVDR

MST1L

161

Q2TV78
YRTVNETWHGSCFRC

LIMK2

26

P53671
VYWTCRDQARMGCRS

FLYWCH1

536

Q4VC44
RCQEVIGFGRSCWSR

JAG2

861

Q9Y219
IIRIWSAGCCCRYRG

KCNQ5

176

Q9NR82
CCCRYRGWQGRFRFA

KCNQ4

156

P56696
RARAIWQECQDCAYF

MCF2L2

721

Q86YR7
IWRRRCREEYGVCEN

FBXO31

106

Q5XUX0
FECGWCVAERRCSLR

PLXNA1

826

Q9UIW2
AYWGIDEARLERCCL

KCNG2

106

Q9UJ96
YAVCTIGGRWLEERC

PEX2

106

P28328
IWRRCCRAASAAVLA

NUS1

36

Q96E22
TDWRERFCAICDRYP

FUT7

311

Q11130
RWAYARCPDVDECRL

MEGF8

1066

Q7Z7M0
RTCGEGYQFRVVRCW

ADAMTSL2

636

Q86TH1
INDCRRGCYFVLDWL

LAS1L

166

Q9Y4W2
CARCGRQIYASDWVR

LHX6

131

Q9UPM6
GALLAWCRRQCEGYR

MICALL1

6

Q8N3F8
WCRRQCEGYRGVEIR

MICALL1

11

Q8N3F8
WCVRQRYCRLLNAVR

IQCF5

81

A8MTL0
LVRECERRYCAFNNW

GIMAP5

176

Q96F15
VCRDRCLQHSYAGAW

ICOSLG

276

O75144
AWFTCRRCYRGNLVS

PRG2

121

P13727
DCRSGWEGRFCQREV

PROC

121

P04070
SVEMYRQALLWGCRC

PLCB3

346

Q01970
DCRLQGRCYSWNRRD

PAPPA2

611

Q9BXP8
GRCYSWNRRDGLCHV

PAPPA2

616

Q9BXP8
RWATRVFAAECVCRI

HEATR5A

1216

Q86XA9
AFRRPCYSWGVCAAI

FFAR1

116

O14842
CARAWRELSERACCF

LINC00473

86

A8K010
ICAYLNRHWVRRECD

CUL1

136

Q13616
RDPGVRWEYCNLTQC

LPA

91

P08519
RDPGVRWEYCNLTQC

LPA

661

P08519
TVREGQTICVRFWRC

PRMT5

591

O14744
RDGTCIIWDLNRLCY

LYST

3636

Q99698
RCYRISSDRYECSWQ

IL12RB1

51

P42701
CSWKGCERRFARSDE

KLF10

401

Q13118
CRRTCLFYTIRAQAW

CUL9

1311

Q8IWT3
SYTRDCATWVNVVCR

FRY

2196

Q5TBA9
CVWCNGEEYRGAVDR

MST1

191

P26927
GCYRRWNADGSASCV

C1orf159

86

Q96HA4
ATWCRALAEYARACA

OTOG

386

Q6ZRI0
ALVRRGWRCGYLECS

RASL10A

146

Q92737
VCASWARRGFCDARR

MMP23B

261

O75900
IGGSTWYLVCDRCRE

MYCBP2

3291

O75592
GRCVRRFAGVQCVWS

CHSY1

256

Q86X52
AATARCYTERKWICR

CLEC2B

131

Q92478
CRRRKRTYWNDSCGE

WEE1

251

P30291
LRSNRVEYCWCNSGR

PLAT

61

P00750
ASAYRRRCCRLCIWL

XKR7

166

Q5GH72
CFARGWRLDRVYGTC

SBSPON

36

Q8IVN8
WRLDRVYGTCFCDQA

SBSPON

41

Q8IVN8
RAEACEREGFCWNGR

USP49

321

Q70CQ1
EVWHTGERRYQCIFC

ZBTB4

356

Q9P1Z0
INQAADCWGIRCLRY

STOML2

161

Q9UJZ1
LYCLCRSDSWAGREV

PLPP6

151

Q8IY26
VCTLWQEGRCFRRVC

ZC3H11B

36

A0A1B0GTU1
ACRWCERRFTQSGDL

ZBTB42

391

B2RXF5
ECGRCFRQRWSLAVH

ZNF689

461

Q96CS4
RVDEYCERVWCRGTT

SEMA3G

721

Q9NS98
RCCRTGVDEYGWIAA

TMEM213

61

A2RRL7
SGCVYLCSRWRLAAD

TMEM272

171

A0A1B0GTI8
RAYCGQCSERIWGLA

PRKCZ

141

Q05513