Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	IgM binding	LILRB3 LILRB1 CD22	5.12e-05	11	138	3	GO:0001791
GeneOntologyMolecularFunction	immunoglobulin binding	LILRB3 VWF LILRB1 CD22	1.08e-04	36	138	4	GO:0019865
GeneOntologyMolecularFunction	coreceptor activity	RGMB LILRB3 TMIGD2 LILRB1 CD22	1.41e-04	72	138	5	GO:0015026
GeneOntologyCellularComponent	external side of plasma membrane	CFH IL12RB1 ICOSLG VWF FCRLA LILRB1 KLRC4 CFHR4 CD22 UMODL1 IL21R PKHD1 SCART1 OSMR LY75	2.18e-06	519	140	15	GO:0009897
GeneOntologyCellularComponent	cell surface	CFH IL12RB1 ICOSLG RC3H2 VWF FCRLA LILRB1 KLRC4 CFHR4 TGFB2 CD22 UMODL1 IL21R ANGPTL3 PKHD1 SCART1 OSMR LY75 FERMT2 CTSZ IGSF3	1.60e-05	1111	140	21	GO:0009986
GeneOntologyCellularComponent	side of membrane	CFH IL12RB1 ICOSLG RGMB VWF FCRLA LILRB1 KLRC4 CFHR4 CD22 UMODL1 IL21R PKHD1 SCART1 OSMR LY75 FERMT2	7.92e-05	875	140	17	GO:0098552
MousePheno	abnormal iris stroma morphology	LGR4 TGFB2 FOXF2	7.08e-05	10	120	3	MP:0005208
MousePheno	artery occlusion	CFH CFHR4	7.31e-05	2	120	2	MP:0006134
MousePheno	abnormal hepatic portal vein thrombosis	CFH CFHR4	7.31e-05	2	120	2	MP:0031159
MousePheno	white pupil	CFH CFHR4	7.31e-05	2	120	2	MP:0006242
MousePheno	decreased serum complement activity	CFH CFHR4	7.31e-05	2	120	2	MP:0012553
MousePheno	decreased complement C5 level	CFH CFHR4	7.31e-05	2	120	2	MP:0012609
MousePheno	abnormal complement C5 level	CFH CFHR4	7.31e-05	2	120	2	MP:0012608
MousePheno	abnormal visual acuity	CFH PDE6B CFHR4	1.66e-04	13	120	3	MP:0011832
MousePheno	decreased visual acuity	CFH PDE6B CFHR4	1.66e-04	13	120	3	MP:0006149
MousePheno	abnormal kidney venous thrombosis	CFH CFHR4	2.18e-04	3	120	2	MP:0031161
MousePheno	increased susceptilbility to retina ischemic injury	CFH CFHR4	2.18e-04	3	120	2	MP:0012049
MousePheno	abnormal germ layer development	DSP IFT172 AFDN PISD FERMT2 SMAD1 SMAD5	2.40e-04	144	120	7	MP:0001674
Domain	WD_REPEATS_1	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 HERC2 EIF2A	1.77e-07	278	140	13	PS00678
Domain	WD_REPEATS_2	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 HERC2 EIF2A	1.85e-07	279	140	13	PS50082
Domain	WD_REPEATS_REGION	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 HERC2 EIF2A	1.85e-07	279	140	13	PS50294
Domain	WD40_repeat	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 HERC2	9.97e-07	272	140	12	IPR001680
Domain	-	WDR4 DPH7 IFT172 EML6 CFAP43 SEMA3G DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 EIF2A	1.37e-06	333	140	13	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR4 DPH7 IFT172 EML6 CFAP43 SEMA3G DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 EIF2A	1.46e-06	335	140	13	IPR015943
Domain	WD40_repeat_dom	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80 EIF2A	2.49e-06	297	140	12	IPR017986
Domain	Ig-like_fold	IGSF8 IL12RB1 ICOSLG LILRB3 COL20A1 TMIGD2 LILRA6 SEMA3G FCRLA CMYA5 LILRB1 CD22 UMODL1 IL21R PKHD1 SIGLEC1 OSMR IGSF3	5.70e-06	706	140	18	IPR013783
Domain	WD40	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80	5.73e-06	268	140	11	SM00320
Domain	WD40	WDR4 DPH7 IFT172 EML6 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80	2.61e-05	259	140	10	PF00400
Domain	FAM209	FAM209A FAM209B	5.58e-05	2	140	2	PF15206
Domain	FAM209	FAM209A FAM209B	5.58e-05	2	140	2	IPR027943
Domain	-	IGSF8 IL12RB1 COL20A1 TMIGD2 SEMA3G FCRLA CMYA5 LILRB1 CD22 UMODL1 IL21R PKHD1 SIGLEC1 OSMR IGSF3	1.38e-04	663	140	15	2.60.40.10
Domain	2-Hacid_dh_C	CTBP1 CTBP2	3.31e-04	4	140	2	PF02826
Domain	2-Hacid_dh	CTBP1 CTBP2	3.31e-04	4	140	2	PF00389
Domain	D_2_HYDROXYACID_DH_1	CTBP1 CTBP2	3.31e-04	4	140	2	PS00065
Domain	D_2_HYDROXYACID_DH_2	CTBP1 CTBP2	3.31e-04	4	140	2	PS00670
Domain	D_2_HYDROXYACID_DH_3	CTBP1 CTBP2	3.31e-04	4	140	2	PS00671
Domain	D-isomer_2_OHA_DH_cat_dom	CTBP1 CTBP2	3.31e-04	4	140	2	IPR006139
Domain	D-isomer_DH_CS	CTBP1 CTBP2	3.31e-04	4	140	2	IPR029753
Domain	IG	IGSF8 ICOSLG LILRB3 TMIGD2 LILRA6 SEMA3G FCRLA LILRB1 CD22 SIGLEC1 IGSF3	3.36e-04	421	140	11	SM00409
Domain	Ig_sub	IGSF8 ICOSLG LILRB3 TMIGD2 LILRA6 SEMA3G FCRLA LILRB1 CD22 SIGLEC1 IGSF3	3.36e-04	421	140	11	IPR003599
Domain	Znf_FCS	MBTD1 L3MBTL2	5.50e-04	5	140	2	IPR012313
Domain	TIF_beta_prop-like	WDHD1 EIF2A	5.50e-04	5	140	2	IPR013979
Domain	eIF2A	WDHD1 EIF2A	5.50e-04	5	140	2	PF08662
Domain	D-isomer_DH_NAD-bd	CTBP1 CTBP2	5.50e-04	5	140	2	IPR006140
Domain	ig	LILRB3 TMIGD2 LILRA6 SEMA3G LILRB1 CD22 SIGLEC1	5.81e-04	190	140	7	PF00047
Domain	Immunoglobulin	LILRB3 TMIGD2 LILRA6 SEMA3G LILRB1 CD22 SIGLEC1	5.81e-04	190	140	7	IPR013151
Domain	Sushi	CFH CSMD3 CFHR4 PAPPA	6.19e-04	52	140	4	PF00084
Domain	SEA	TMPRSS6 UMODL1 MUC3A	6.54e-04	23	140	3	PS50024
Domain	SEA_dom	TMPRSS6 UMODL1 MUC3A	6.54e-04	23	140	3	IPR000082
Domain	CCP	CFH CSMD3 CFHR4 PAPPA	7.15e-04	54	140	4	SM00032
Domain	ZF_FCS	MBTD1 L3MBTL2	8.20e-04	6	140	2	PS51024
Domain	SUSHI	CFH CSMD3 CFHR4 PAPPA	8.21e-04	56	140	4	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CSMD3 CFHR4 PAPPA	8.78e-04	57	140	4	IPR000436
Domain	Hematopoietin_rcpt_Gp130_CS	IL12RB1 OSMR	1.14e-03	7	140	2	IPR003529
Domain	IG_LIKE	IGSF8 ICOSLG LILRB3 TMIGD2 LILRA6 SEMA3G FCRLA LILRB1 CD22 SIGLEC1 IGSF3	1.19e-03	491	140	11	PS50835
Domain	ConA-like_dom	COL20A1 LAMA1 CMYA5 NBEAL2 SEL1L3 PAPPA TRIM50	1.33e-03	219	140	7	IPR013320
Domain	Ig-like_dom	IGSF8 ICOSLG LILRB3 TMIGD2 LILRA6 SEMA3G FCRLA LILRB1 CD22 SIGLEC1 IGSF3	1.45e-03	503	140	11	IPR007110
Domain	DWB	SMAD1 SMAD5	1.52e-03	8	140	2	SM00524
Domain	MH2	SMAD1 SMAD5	1.52e-03	8	140	2	PS51076
Domain	MH1	SMAD1 SMAD5	1.52e-03	8	140	2	PS51075
Domain	HEMATOPO_REC_L_F2	IL12RB1 OSMR	1.52e-03	8	140	2	PS01353
Domain	-	SMAD1 SMAD5	1.52e-03	8	140	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD5	1.52e-03	8	140	2	IPR013019
Domain	Dwarfin	SMAD1 SMAD5	1.52e-03	8	140	2	IPR013790
Domain	MH2	SMAD1 SMAD5	1.52e-03	8	140	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD5	1.52e-03	8	140	2	IPR001132
Domain	MBT	MBTD1 L3MBTL2	1.94e-03	9	140	2	SM00561
Domain	MBT	MBTD1 L3MBTL2	1.94e-03	9	140	2	PS51079
Domain	Ig_2	FCRLA LILRB1 CD22 SIGLEC1	2.21e-03	73	140	4	PF13895
Domain	-	VWF COL20A1 CACNA2D4 XRCC6	2.32e-03	74	140	4	3.40.50.410
Domain	MBT	MBTD1 L3MBTL2	2.41e-03	10	140	2	PF02820
Domain	Mbt	MBTD1 L3MBTL2	2.41e-03	10	140	2	IPR004092
Domain	FN3	IL12RB1 COL20A1 CMYA5 UMODL1 IL21R OSMR	2.73e-03	185	140	6	SM00060
Pubmed	Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.	CTBP1 CTBP2 SMAD1 SMAD5	1.89e-08	8	143	4	12714599
Pubmed	Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.	TMPRSS6 SMAD1 SMAD5	6.77e-07	5	143	3	30958854
Pubmed	Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring.	TGFB2 SMAD1 FOXF2 SMAD5	1.89e-06	22	143	4	36314682
Pubmed	Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.	LAMA1 TGFB2 SMAD1 SMAD5	4.47e-06	27	143	4	35894043
Pubmed	Prdm16 is required for normal palatogenesis in mice.	TGFB2 SMAD1 SMAD5	5.61e-06	9	143	3	20007998
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CFH IL12RB1 FCRLA SH2B2 KLRC4 CFHR4 TGFB2 FCGBP CD22 UMODL1 IL21R CTBP1 SIGLEC1 LY75	8.34e-06	824	143	14	20237496
Pubmed	Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.	LGR4 SMAD1 SMAD5	1.10e-05	11	143	3	18651655
Pubmed	Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.	TGFB2 SMAD1 FOXF2 SMAD5	1.15e-05	34	143	4	26120030
Pubmed	Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.	TGFB2 SMAD1 SMAD5	1.46e-05	12	143	3	15923624
Pubmed	Absence of complement factor H reduces physical performance in C57BL6 mice.	CFH CFHR4	1.68e-05	2	143	2	32962822
Pubmed	Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.	CFH CFHR4	1.68e-05	2	143	2	20538999
Pubmed	The interaction between factor H and Von Willebrand factor.	CFH VWF	1.68e-05	2	143	2	23991205
Pubmed	Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.	CFH CFHR4	1.68e-05	2	143	2	4992636
Pubmed	Retinal changes precede visual dysfunction in the complement factor H knockout mouse.	CFH CFHR4	1.68e-05	2	143	2	23844226
Pubmed	Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.	CD22 SIGLEC1	1.68e-05	2	143	2	7925291
Pubmed	Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.	UGT2B15 UGT2B17	1.68e-05	2	143	2	32660355
Pubmed	Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.	CFH CFHR4	1.68e-05	2	143	2	26374608
Pubmed	A gene locus concerned with an antigenic serum substance in Mus musculus.	CFH CFHR4	1.68e-05	2	143	2	4955525
Pubmed	Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells.	CFH CFHR4	1.68e-05	2	143	2	2533512
Pubmed	Complement factor H: spatial and temporal expression and localization in the eye.	CFH CFHR4	1.68e-05	2	143	2	16936129
Pubmed	Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.	CFH CFHR4	1.68e-05	2	143	2	33558624
Pubmed	Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.	CFH CFHR4	1.68e-05	2	143	2	37940659
Pubmed	C-Terminal Binding Protein is Involved in Promoting to the Carcinogenesis of Human Glioma.	CTBP1 CTBP2	1.68e-05	2	143	2	27699603
Pubmed	Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.	CFH CFHR4	1.68e-05	2	143	2	19620346
Pubmed	Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.	CFH CFHR4	1.68e-05	2	143	2	30705315
Pubmed	BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.	SMAD1 SMAD5	1.68e-05	2	143	2	26711875
Pubmed	A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.	CFH CFHR4	1.68e-05	2	143	2	33859044
Pubmed	Regulation of age-related macular degeneration-like pathology by complement factor H.	CFH CFHR4	1.68e-05	2	143	2	25991857
Pubmed	The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.	SMAD1 SMAD5	1.68e-05	2	143	2	11451566
Pubmed	The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.	UGT2B15 UGT2B17	1.68e-05	2	143	2	1909870
Pubmed	Serological survey of complement factor H in common laboratory and wild mice: a new third allotype.	CFH CFHR4	1.68e-05	2	143	2	2522412
Pubmed	MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma.	WDR4 EIF2A	1.68e-05	2	143	2	34244479
Pubmed	Absence of complement factor H alters bone architecture and dynamics.	CFH CFHR4	1.68e-05	2	143	2	30107932
Pubmed	Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.	CFH CFHR4	1.68e-05	2	143	2	34054871
Pubmed	Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.	UGT2B15 UGT2B17	1.68e-05	2	143	2	24121496
Pubmed	Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.	CFH CFHR4	1.68e-05	2	143	2	17562771
Pubmed	Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.	CFH CFHR4	1.68e-05	2	143	2	27397653
Pubmed	Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.	CFH CFHR4	1.68e-05	2	143	2	29392311
Pubmed	The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.	CFH CFHR4	1.68e-05	2	143	2	22174452
Pubmed	Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.	CTBP1 CTBP2	1.68e-05	2	143	2	7479821
Pubmed	Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.	CFH CFHR4	1.68e-05	2	143	2	22875704
Pubmed	Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179.	PDE6B GPR179	1.68e-05	2	143	2	25613321
Pubmed	Local complement factor H protects kidney endothelial cell structure and function.	CFH CFHR4	1.68e-05	2	143	2	34139209
Pubmed	Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.	UGT2B15 UGT2B17	1.68e-05	2	143	2	24267955
Pubmed	Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.	CFH CFHR4	1.68e-05	2	143	2	32849636
Pubmed	Complement factor h is critical in the maintenance of retinal perfusion.	CFH CFHR4	1.68e-05	2	143	2	19541934
Pubmed	Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.	CFH CFHR4	1.68e-05	2	143	2	17921253
Pubmed	The role of complement dysregulation in AMD mouse models.	CFH CFHR4	1.68e-05	2	143	2	24664701
Pubmed	Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.	CFH CFHR4	1.68e-05	2	143	2	26149919
Pubmed	Murine protein H is comprised of 20 repeating units, 61 amino acids in length.	CFH CFHR4	1.68e-05	2	143	2	2940596
Pubmed	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.	CFH CFHR4	1.68e-05	2	143	2	32165615
Pubmed	Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.	UGT2B15 UGT2B17	1.68e-05	2	143	2	22170718
Pubmed	Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness.	PDE6B GPR179	1.68e-05	2	143	2	22325361
Pubmed	Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.	LILRB3 LILRA6	1.68e-05	2	143	2	33526815
Pubmed	Death by color: differential cone loss in the aging mouse retina.	CFH CFHR4	1.68e-05	2	143	2	24929970
Pubmed	Assembly of human C-terminal binding protein (CtBP) into tetramers.	CTBP1 CTBP2	1.68e-05	2	143	2	29700119
Pubmed	Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.	CFH CFHR4	1.68e-05	2	143	2	23436934
Pubmed	Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.	CFH CFHR4	1.68e-05	2	143	2	23469078
Pubmed	Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness.	CFH CFHR4	1.68e-05	2	143	2	15574507
Pubmed	BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.	SMAD1 SMAD5	1.68e-05	2	143	2	32210087
Pubmed	Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.	CFH CFHR4	1.68e-05	2	143	2	23133374
Pubmed	NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).	CTBP1 CTBP2	1.68e-05	2	143	2	33524397
Pubmed	Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.	UGT2B15 UGT2B17	1.68e-05	2	143	2	3105095
Pubmed	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	UGT2B15 UGT2B17	1.68e-05	2	143	2	17848572
Pubmed	Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance.	CTBP1 CTBP2	1.68e-05	2	143	2	20964627
Pubmed	Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding.	CFH CFHR4	1.68e-05	2	143	2	1486806
Pubmed	Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.	CFH CFHR4	1.68e-05	2	143	2	17517971
Pubmed	Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.	CFH CFHR4	1.68e-05	2	143	2	20445496
Pubmed	NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2.	CTBP1 CTBP2	1.68e-05	2	143	2	34997967
Pubmed	BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow.	SMAD1 SMAD5	1.68e-05	2	143	2	23387849
Pubmed	Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.	UGT2B15 UGT2B17	1.68e-05	2	143	2	27496708
Pubmed	High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.	CFH CFHR4	1.68e-05	2	143	2	32737203
Pubmed	Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease.	CFH CFHR4	1.68e-05	2	143	2	16597679
Pubmed	The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status.	CFH VWF	1.68e-05	2	143	2	24014239
Pubmed	Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure.	CTBP1 CTBP2	1.68e-05	2	143	2	10364211
Pubmed	Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.	SMAD1 SMAD5	1.68e-05	2	143	2	8799132
Pubmed	Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.	CFH CFHR4	1.68e-05	2	143	2	25447048
Pubmed	The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.	UGT2B15 UGT2B17	1.68e-05	2	143	2	17698910
Pubmed	Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.	CFH CFHR4	1.68e-05	2	143	2	31354740
Pubmed	Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.	LILRB3 LILRA6	1.68e-05	2	143	2	36449053
Pubmed	CTBP1 and CTBP2 mutations underpinning neurological disorders: a systematic review.	CTBP1 CTBP2	1.68e-05	2	143	2	36331689
Pubmed	Differential spatial expression and subcellular localization of CtBP family members in rodent brain.	CTBP1 CTBP2	1.68e-05	2	143	2	22745816
Pubmed	Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b.	CFH CFHR4	1.68e-05	2	143	2	8615824
Pubmed	BMP signaling dynamics in embryonic orofacial tissue.	SMAD1 SMAD5	1.68e-05	2	143	2	18446813
Pubmed	Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site.	CFH CFHR4	1.68e-05	2	143	2	30642982
Pubmed	Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.	SMAD1 SMAD5	1.68e-05	2	143	2	21723296
Pubmed	Cryo-EM structure of CtBP2 confirms tetrameric architecture.	CTBP1 CTBP2	1.68e-05	2	143	2	33264605
Pubmed	Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.	CFH CFHR4	1.68e-05	2	143	2	29398083
Pubmed	Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro.	SMAD1 SMAD5	1.68e-05	2	143	2	24297369
Pubmed	Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.	CFH CFHR4	1.68e-05	2	143	2	29288229
Pubmed	Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.	CFH CFHR4	1.68e-05	2	143	2	33708358
Pubmed	Siglec-1 and -2 as potential biomarkers in autoimmune disease.	CD22 SIGLEC1	1.68e-05	2	143	2	26752092
Pubmed	Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration.	CFH CFHR4	1.68e-05	2	143	2	28819420
Pubmed	Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.	UGT2B15 UGT2B17	1.68e-05	2	143	2	3117546
Pubmed	Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.	CFH CFHR4	1.68e-05	2	143	2	23799019
Pubmed	Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients.	LILRB3 LILRA6	1.68e-05	2	143	2	19617579
Pubmed	Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.	CTBP1 CTBP2	1.68e-05	2	143	2	24657618
Pubmed	Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.	CFH CFHR4	1.68e-05	2	143	2	24370827
Pubmed	CtBPs promote cell survival through the maintenance of mitotic fidelity.	CTBP1 CTBP2	1.68e-05	2	143	2	19506021
Pubmed	Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.	CFH CFHR4	1.68e-05	2	143	2	25921262
Cytoband	21q22.3	ICOSLG WDR4 UBASH3A UMODL1 TRAPPC10	5.32e-05	128	143	5	21q22.3
Cytoband	19q13.4	LILRB3 LILRA6 LILRB1 ZNF304	1.13e-04	79	143	4	19q13.4
Cytoband	19q13.1	FCGBP CD22 CATSPERG	6.89e-04	55	143	3	19q13.1
Cytoband	4q13	UGT2B15 UGT2B17	9.85e-04	15	143	2	4q13
Cytoband	20q13.31	FAM209A FAM209B	1.12e-03	16	143	2	20q13.31
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	ICOSLG WDR4 SIM2 UBASH3A UMODL1 TRAPPC10	1.23e-03	377	143	6	chr21q22
Cytoband	9q21.32	SPATA31D4 SPATA31D3	1.59e-03	19	143	2	9q21.32
GeneFamily	WD repeat domain containing	WDR4 DPH7 IFT172 EML6 CFAP43 DNAI3 DMXL1 LLGL2 WDHD1 NBEAL2 IFT80	2.18e-07	262	100	11	362
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IGSF8 IL12RB1 ICOSLG LILRB3 LILRA6 LILRB1 CD22 IL21R SIGLEC1 LY75	6.52e-05	394	100	10	471
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CSMD3 CFHR4 PAPPA	2.78e-04	57	100	4	1179
GeneFamily	CD molecules\|Inhibitory leukocyte immunoglobulin like receptors	LILRB3 LILRB1	3.00e-04	5	100	2	1182
GeneFamily	SMAD family	SMAD1 SMAD5	8.30e-04	8	100	2	750
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	MBTD1 L3MBTL2	1.06e-03	9	100	2	1263
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	ICOSLG CD22 SIGLEC1	1.40e-03	40	100	3	592
ToppCell	356C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PALD1 IL12RB1 LILRB3 VWF DSP BEND2 BMX TMEM178A	4.83e-08	159	143	8	0a3a363b30a8c741e1a3e2525725108d03c21776
ToppCell	356C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PALD1 IL12RB1 LILRB3 VWF DSP BEND2 BMX TMEM178A	4.83e-08	159	143	8	299e2162a82e31196d7f3a110c2db622349edfff
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SLCO2B1 TMPRSS6 SLC22A7 CACNA2D4 ANGPTL3 MUC3A ABCG5 ZG16	1.91e-07	190	143	8	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	LILRB3 SLCO2B1 LILRA6 LGR4 SIGLEC1 ARHGAP20 CTSZ	1.32e-06	170	143	7	439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 LGR4 LLGL2 TMEM178A PKHD1 TRIM50 CRISPLD1	1.73e-06	177	143	7	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ZC3H12B SEMA3G BMX CTBP2 OSMR CRISPLD1	2.00e-06	181	143	7	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	lymphoid-B_cell-Naive_B_cell\|lymphoid / Lineage, cell class and subclass	ICOSLG FCRLA LILRB1 SH2B2 CD22 SEL1L3 CTSZ	2.76e-06	190	143	7	b8b05894e811e431d797ac4fa3ccff4963a154e7
ToppCell	lymphoid-B_cell\|lymphoid / Lineage, cell class and subclass	ICOSLG FCRLA LILRB1 SH2B2 CD22 SEL1L3 CTSZ	2.76e-06	190	143	7	c451de643ee08c2ff1093e807c65d724237473c5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 CMYA5 LLGL2 PKHD1 KIAA1958 AFDN PLEKHA7	3.06e-06	193	143	7	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 SIM2 LLGL2 PKHD1 KIAA1958 PLEKHA7	3.17e-06	194	143	7	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 CMYA5 LLGL2 PKHD1 KIAA1958 AFDN PLEKHA7	3.17e-06	194	143	7	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 SIM2 LLGL2 PKHD1 KIAA1958 PLEKHA7	3.39e-06	196	143	7	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 SIM2 LLGL2 PKHD1 KIAA1958 PLEKHA7	3.39e-06	196	143	7	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PSMB11 SIM2 UBASH3A TGFB2 KY FCGBP	3.50e-06	127	143	6	9bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DSP TGFB2 LLGL2 PLA2G4B NBEAL2 PKHD1 IFT80	3.75e-06	199	143	7	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DSP TGFB2 LLGL2 PLA2G4B NBEAL2 PKHD1 IFT80	3.87e-06	200	143	7	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ICOSLG EML6 FCRLA DMXL1 FARP2 CD22 SEL1L3	3.87e-06	200	143	7	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB3 SLCO2B1 LILRA6 LILRB1 TRIM50 SIGLEC1 CTSZ	3.87e-06	200	143	7	a1ae299cf77580a6d1a728ee591888b6d70a19d6
ToppCell	COVID-19_Severe-B_cell\|World / disease group, cell group and cell class	ICOSLG FCRLA BMX CD22 ARHGAP20 ZNF304	8.77e-06	149	143	6	9a9fcbf7e8a6811958f3fd2d36315e19ab2b1127
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSP KLF1 PKHD1 ZFHX2 PLEKHA7 IGSF3	1.18e-05	157	143	6	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	10x5'-blood-Lymphocytic_B-ABC_aged-B_memory\|blood / Manually curated celltypes from each tissue	LGR4 FCRLA FARP2 CD22 SEL1L3 ZFHX2	1.51e-05	164	143	6	0424b23fc540580e7c15c50a7a03dff7c25014fa
ToppCell	Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, Lineage and Cell Type	FCRLA SIM2 TGFB2 CD22 SEL1L3 PAPPA	1.73e-05	168	143	6	5b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PALD1 DSP BMX TLL1 SMAD1 IGSF3	1.73e-05	168	143	6	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 PLCXD2 FCRLA UBASH3A CD22 IL21R	1.73e-05	168	143	6	68ef5d1043fca804032669bf990edf110d65cf63
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PALD1 DSP BMX TLL1 SMAD1 IGSF3	1.73e-05	168	143	6	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	CFAP43 CMYA5 DNAI3 TGFB2 UGT2B17 PLEKHA7	1.92e-05	171	143	6	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLCO2B1 LILRA6 LGR4 TMEM178A SIGLEC1 ARHGAP20	1.92e-05	171	143	6	7c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 FCRLA CMYA5 WDHD1 CD22 IL21R	1.92e-05	171	143	6	a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 FCRLA CMYA5 WDHD1 CD22 IL21R	1.92e-05	171	143	6	43d8fd9b9546e84a652564fe96b514b34b06262b
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH VWF TGFB2 BMX TLL1 CRISPLD1	1.98e-05	172	143	6	fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH VWF TGFB2 BMX TLL1 CRISPLD1	1.98e-05	172	143	6	745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CFH VWF SEMA3G BMX OSMR	2.16e-05	104	143	5	5d9cd14e53a2f1060e528abf6c0694be9d72c356
ToppCell	severe-B_memory\|World / disease stage, cell group and cell class	ICOSLG EML6 LGR4 FCRLA CD22 SEL1L3	2.26e-05	176	143	6	4e5c6b1aa5ffd13593a6bcd1e1253c1737c5c2b4
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH VWF TGFB2 BMX TLL1 CRISPLD1	2.33e-05	177	143	6	6f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSP SLCO2B1 LLGL2 NBEAL2 PKHD1 IFT80	2.33e-05	177	143	6	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF ZC3H12B SEMA3G BMX OSMR CRISPLD1	2.56e-05	180	143	6	67c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell	3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF SH2B2 TLL1 SCART1 OSMR FERMT2	2.72e-05	182	143	6	d996ceb77c83591df4cef144ca72862f31d9777f
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DSP FCRLA LILRB1 SH2B2 DMXL1 CD22	2.81e-05	183	143	6	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ACSS1 LAMA1 LGR4 SIM2 USP2	2.81e-05	183	143	6	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GAD1 VWF TGFB2 BMX TLL1 NME1	2.90e-05	184	143	6	3b0389c3a5a16697de860e98ebc48ed39ede646f
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 VWF SEMA3G BMX OSMR CRISPLD1	2.98e-05	185	143	6	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ACSS1 LAMA1 LGR4 SIM2 USP2	2.98e-05	185	143	6	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRB3 SLCO2B1 LILRA6 LILRB1 IL21R CTSZ	3.08e-05	186	143	6	bec4767eaca28e41da373274704895eba75063e2
ToppCell	21-Trachea-Epithelial-Goblet-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	CFH FCGBP ASB11 TLL1 UGT2B15 SPDEF	3.08e-05	186	143	6	f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ACSS1 LAMA1 LGR4 SIM2 USP2	3.17e-05	187	143	6	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH VWF SEMA3G BMX OSMR LY75	3.17e-05	187	143	6	698ae9eefa8ba97fea8ea61e4e868edd194de03b
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Endo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH VWF SEMA3G BMX OSMR LY75	3.17e-05	187	143	6	ed8816433d1086a634892502898255b487a2d4a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 SIM2 FCGBP SEL1L3 PKHD1	3.17e-05	187	143	6	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF SEMA3G TGFB2 BMX OSMR CRISPLD1	3.17e-05	187	143	6	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH VWF SEMA3G BMX OSMR LY75	3.17e-05	187	143	6	d8b09398400a178b03e641af1476c4dac0c6e82a
ToppCell	droplet-Fat-Mat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCXD2 FCRLA CD22 IL21R PAPPA ZG16	3.27e-05	188	143	6	d4113d0aaeefe6e07026cd02cd53ebc13a41a7ac
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ICOSLG EML6 FCRLA CD22 SEL1L3 AFDN	3.27e-05	188	143	6	229108e7e3db49e1cfd747d69e338394139d95b3
ToppCell	droplet-Fat-Mat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCXD2 FCRLA CD22 IL21R PAPPA ZG16	3.27e-05	188	143	6	c9ed37e71eda66659bf4dd4dbbe4e852eefb8339
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DSP LLGL2 FCGBP SEL1L3 PKHD1 PLEKHA7	3.27e-05	188	143	6	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DSP LAMA1 LLGL2 SEL1L3 PKHD1 UGT2B17	3.36e-05	189	143	6	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 LLGL2 PKHD1 TRIM50 FERMT2	3.36e-05	189	143	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 LLGL2 PKHD1 TRIM50 FERMT2	3.36e-05	189	143	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ACSS1 CMYA5 ASB11 GSG1L PLEKHA7	3.36e-05	189	143	6	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRD5A1 ADGRB2 LGR4 CMYA5 GSG1L CRISPLD1	3.36e-05	189	143	6	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 LAMA1 LGR4 SIM2 LLGL2 TRIM50	3.36e-05	189	143	6	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ACSS1 CMYA5 ASB11 GSG1L PLEKHA7	3.36e-05	189	143	6	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRD5A1 ADGRB2 LGR4 CMYA5 GSG1L CRISPLD1	3.36e-05	189	143	6	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 SIM2 FCGBP SEL1L3 PKHD1	3.46e-05	190	143	6	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ACSS1 LAMA1 LGR4 SIM2 TRIM50	3.46e-05	190	143	6	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	390C-Myeloid-Macrophage\|390C / Donor, Lineage, Cell class and subclass (all cells)	LILRB3 SLCO2B1 LILRA6 FCGBP SIGLEC1 CTSZ	3.46e-05	190	143	6	f933d971f092c4e56e9f670a9205b688c8b1ca28
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 LGR4 SIM2 FCGBP SEL1L3 PKHD1	3.46e-05	190	143	6	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PALD1 GAD1 VWF BMX TLL1 SMAD1	3.46e-05	190	143	6	6b704deeb44e1ffa10e604d0e5612b022f6cd9a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EML6 LAMA1 CFAP43 SIM2 SEL1L3 PKHD1	3.57e-05	191	143	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	healthy_donor-Lymphocytic-B_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ICOSLG DSP EML6 FCRLA CD22 SEL1L3	3.67e-05	192	143	6	7d9e5772b6e531b50ed4e4d6304ef11235f27f37
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSS1 LAMA1 SIM2 USP2 FCGBP PKHD1	3.67e-05	192	143	6	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	healthy_donor-Lymphocytic-B_cell-\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ICOSLG DSP EML6 FCRLA CD22 SEL1L3	3.67e-05	192	143	6	975312f9d6cede4d4f5b737e481e5c73accc8c50
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CSMD3 KLF1 UMODL1 PKHD1 SPDEF ABCG5	3.78e-05	193	143	6	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSP EML6 LLGL2 FCGBP SEL1L3 SPDEF	3.78e-05	193	143	6	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 SIM2 LLGL2 PKHD1 AFDN PLEKHA7	3.78e-05	193	143	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 SIM2 LLGL2 PKHD1 AFDN PLEKHA7	3.78e-05	193	143	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 CMYA5 LLGL2 PKHD1 KIAA1958 PLEKHA7	3.78e-05	193	143	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSP EML6 LLGL2 FCGBP SEL1L3 SPDEF	3.78e-05	193	143	6	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 SIM2 LLGL2 PKHD1 AFDN PLEKHA7	3.89e-05	194	143	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAD1 ACSS1 LGR4 SIM2 USP2 IGSF3	4.01e-05	195	143	6	3123e02d2894c83962ba402085b5e6422ebf8c73
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 SIM2 LLGL2 PKHD1 AFDN PLEKHA7	4.01e-05	195	143	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DSP CALCOCO1 TGFB2 BMX SUMF1 IGSF3	4.12e-05	196	143	6	a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 LLGL2 TMEM178A TRIM50 FERMT2 IGSF3	4.12e-05	196	143	6	f40d10ea7714067585493fdc89744714aa427de8
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DSP CALCOCO1 TGFB2 BMX SUMF1 IGSF3	4.12e-05	196	143	6	b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LILRB3 SLCO2B1 LILRA6 LILRB1 SIGLEC1 CTSZ	4.12e-05	196	143	6	7026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH VWF DSP SEMA3G SMAD1 FOXF2	4.12e-05	196	143	6	ed818de15f84f7f28bd06fd69d7876710da232a0
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH VWF DSP SEMA3G BMX FOXF2	4.24e-05	197	143	6	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RGMB DSP IFT172 LGR4 LLGL2 UGT2B17	4.24e-05	197	143	6	c0250509836f1be04f5e54386191d7bb1e1da652
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH VWF DSP SEMA3G BMX FOXF2	4.24e-05	197	143	6	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	NS-moderate-d_16-33-Myeloid-Non-resident_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ICOSLG SLCO2B1 LILRA6 LILRB1 SIGLEC1 CTSZ	4.36e-05	198	143	6	11a7a553de6786c1e8288251ba0d5c898505c158
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	DSP LLGL2 PLA2G4B NBEAL2 PKHD1 IFT80	4.36e-05	198	143	6	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	LILRB3 SLCO2B1 LILRA6 FCGBP SIGLEC1 CTSZ	4.48e-05	199	143	6	fb63885273d906a85fef178d859d20a311eb8a72
ToppCell	mild-B_memory\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EML6 FCRLA DMXL1 CD22 SEL1L3 UGT2B17	4.48e-05	199	143	6	e6ac9a0959b0de2c6a99298feb7715aa80ade1dd
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DSP TGFB2 LLGL2 PLA2G4B PKHD1 IFT80	4.48e-05	199	143	6	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DSP TGFB2 LLGL2 PLA2G4B PKHD1 IFT80	4.48e-05	199	143	6	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	mild-B_memory\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EML6 FCRLA SH2B2 CD22 SEL1L3 UGT2B17	4.48e-05	199	143	6	025bb65629d9e20c374e8f1ba08c36d1bb569190
ToppCell	wk_08-11-Hematologic\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	LILRB3 SLCO2B1 LILRA6 LILRB1 KLF1 SIGLEC1	4.48e-05	199	143	6	edc9afd7be8543cb93a2bb874a14aad0417dfa92
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH TGFB2 FCGBP TLL1 SEL1L3 DTX2	4.61e-05	200	143	6	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	CFH DSP LGR4 CMYA5 FCGBP SPDEF	4.61e-05	200	143	6	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DSP TGFB2 LLGL2 PLA2G4B PKHD1 IFT80	4.61e-05	200	143	6	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ICOSLG DSP FCRLA DMXL1 CD22 SEL1L3	4.61e-05	200	143	6	222789b897e2a683bbfd1d00b6fd8705015d90df
Disease	DNA repair protein RAD51 homolog 4 measurement	CFH UGT2B15 UGT2B17	1.54e-05	11	136	3	EFO_0801531
Disease	c3d:C3 ratio	CFH CFHR4	2.11e-05	2	136	2	EFO_0008543
Disease	pleckstrin homology domain-containing family A member 7 measurement	CFH PLEKHA7	2.11e-05	2	136	2	EFO_0801891
Disease	immunoglobulin superfamily member 8 measurement	IGSF8 CFH	2.11e-05	2	136	2	EFO_0802622
Disease	Night blindness, congenital stationary	PDE6B GPR179 CACNA2D4	6.21e-05	17	136	3	C0339535
Disease	sialoadhesin measurement	CFH SIGLEC1	6.31e-05	3	136	2	EFO_0020740
Disease	calnexin measurement	CFH CFHR4	6.31e-05	3	136	2	EFO_0801444
Disease	cholic acid glucuronide measurement	UGT2B15 UGT2B17	6.31e-05	3	136	2	EFO_0800574
Disease	complement factor H-related protein 4A measurement	CFH CFHR4	6.31e-05	3	136	2	EFO_0600057
Disease	histone-lysine N-methyltransferase 2D measurement	CFH CFHR4	6.31e-05	3	136	2	EFO_0801683
Disease	squamous cell carcinoma (is_marker_for)	CFH NME1 XRCC6	8.79e-05	19	136	3	DOID:1749 (is_marker_for)
Disease	coagulation factor measurement	CFH VWF CFHR4	1.03e-04	20	136	3	EFO_0004634
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR4	1.26e-04	4	136	2	EFO_0803292
Disease	X-25937 measurement	UGT2B15 UGT2B17	1.26e-04	4	136	2	EFO_0800937
Disease	interleukin-9 measurement	CFH SMAD5	1.26e-04	4	136	2	EFO_0802663
Disease	kallikrein-5 measurement	CFH CFHR4	1.26e-04	4	136	2	EFO_0020515
Disease	alcohol use disorder (implicated_via_orthology)	GAD1 DRD3 KDM5A ANGPTL3 CTBP1 CTBP2	2.97e-04	195	136	6	DOID:1574 (implicated_via_orthology)
Disease	leukocyte immunoglobulin-like receptor subfamily B member 3 measurement	LILRB3 LILRA6	3.13e-04	6	136	2	EFO_0802705
Disease	complement C1s subcomponent measurement	CFH CFHR4	3.13e-04	6	136	2	EFO_0008091
Disease	leukocyte immunoglobulin-like receptor subfamily A member 6 measurement	LILRB3 LILRA6	3.13e-04	6	136	2	EFO_0801767
Disease	Seckel syndrome (implicated_via_orthology)	WDR4 ATR	4.36e-04	7	136	2	DOID:0050569 (implicated_via_orthology)
Disease	X-24574 measurement	UGT2B15 UGT2B17	4.36e-04	7	136	2	EFO_0800897
Disease	Angle Closure Glaucoma	FERMT2 PLEKHA7	4.36e-04	7	136	2	C0017605
Disease	deoxycholic acid glucuronide measurement	UGT2B15 UGT2B17	5.80e-04	8	136	2	EFO_0800575
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR4	7.43e-04	9	136	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR4	7.43e-04	9	136	2	cv:C0019061
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFH CFHR4	7.43e-04	9	136	2	EFO_0801766
Disease	Fuchs endothelial corneal dystrophy	CFH GATD1	9.26e-04	10	136	2	Orphanet_98974
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	UGT2B15 UGT2B17	9.26e-04	10	136	2	EFO_0022090
Disease	primary angle closure glaucoma	FERMT2 PLEKHA7	1.13e-03	11	136	2	EFO_1001506
Disease	Jeune thoracic dystrophy	IFT172 IFT80	1.13e-03	11	136	2	C0265275
Disease	hemopexin measurement	CFH CFHR4	1.13e-03	11	136	2	EFO_0008149
Disease	Gastrointestinal Stromal Sarcoma	STK36 IFT172 C2CD3	1.34e-03	47	136	3	C3179349
Disease	Night blindness, congenital stationary, type 1	PDE6B GPR179	1.35e-03	12	136	2	C3501847
Disease	Night Blindness, Congenital Stationary, Type 1A	PDE6B GPR179	1.35e-03	12	136	2	C3495587
Disease	visceral heterotaxy (is_implicated_in)	PKD1L1 GDF1	1.35e-03	12	136	2	DOID:0050545 (is_implicated_in)
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)	PDE6B GPR179	1.35e-03	12	136	2	C1864877
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	PDE6B GPR179	1.35e-03	12	136	2	C1850362
Disease	X-Linked Csnb	PDE6B GPR179	1.35e-03	12	136	2	C3711543
Disease	diffuse large B-cell lymphoma (is_implicated_in)	CD22 IL21R	1.35e-03	12	136	2	DOID:0050745 (is_implicated_in)
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A	PDE6B GPR179	1.35e-03	12	136	2	C1848172
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 UGT2B17	1.35e-03	12	136	2	EFO_0800291
Disease	complement factor H-related protein 4 measurement	CFH CFHR4 PTAR1	1.51e-03	49	136	3	EFO_0600091
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	PALD1 PKHD1	1.59e-03	13	136	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD5	1.59e-03	13	136	2	DOID:0050787 (implicated_via_orthology)
Disease	Cone-rod synaptic disorder, congenital nonprogressive	PDE6B GPR179	1.59e-03	13	136	2	C4041558
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	UGT2B15 UGT2B17	1.59e-03	13	136	2	EFO_0800293
Disease	X-19141 measurement	UGT2B15 UGT2B17	1.59e-03	13	136	2	EFO_0800799
Disease	icos ligand measurement	CFH ICOSLG	1.59e-03	13	136	2	EFO_0020460
Disease	Gastrointestinal Stromal Tumors	STK36 IFT172 C2CD3	1.60e-03	50	136	3	C0238198
Disease	Ciliopathies	GDF1 PKHD1 AIPL1 IFT80	1.71e-03	110	136	4	C4277690
Disease	Saldino-Noonan Syndrome	IFT172 C2CD3	1.85e-03	14	136	2	C0036069
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 UGT2B17	1.85e-03	14	136	2	EFO_0800283
Disease	Dyskinesia, Medication-Induced	GAD1 DRD3	2.13e-03	15	136	2	C0751088
Disease	Situs ambiguus	PKD1L1 GDF1	2.13e-03	15	136	2	C0266642
Disease	Dyskinesia, Drug-Induced	GAD1 DRD3	2.13e-03	15	136	2	C0013386
Disease	hepcidin:transferrin saturation ratio	TMPRSS6 EML6	2.13e-03	15	136	2	EFO_0007902
Disease	Cocaine-Related Disorders	GAD1 DRD3 SMAD1 SMAD5	2.14e-03	117	136	4	C0236736
Disease	intraocular pressure measurement	ADGRB2 TGFB2 TLL1 PKHD1 HERC2 ARHGAP20 FERMT2 PLEKHA7	2.55e-03	509	136	8	EFO_0004695
Disease	alpha-L-iduronidase measurement	PDE6B CTBP1	2.74e-03	17	136	2	EFO_0020139
Disease	Cocaine Abuse	GAD1 DRD3 SMAD1 SMAD5	2.88e-03	127	136	4	C0009171
Disease	serum hepcidin measurement	TMPRSS6 EML6	3.07e-03	18	136	2	EFO_0004504
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 UGT2B17	3.07e-03	18	136	2	EFO_0800288
Disease	Chronic myeloproliferative disorder	WDR4 ATR	3.43e-03	19	136	2	C1292778
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	FAM209A FAM209B	3.43e-03	19	136	2	EFO_0007044, EFO_0020106
Disease	carotid artery disease (is_marker_for)	VWF PAPPA	3.43e-03	19	136	2	DOID:3407 (is_marker_for)
Disease	etiocholanolone glucuronide measurement	UGT2B15 UGT2B17	3.43e-03	19	136	2	EFO_0800362
Disease	breast carcinoma (is_marker_for)	SRD5A1 AFDN NME1	3.55e-03	66	136	3	DOID:3459 (is_marker_for)
Disease	glaucoma (is_marker_for)	CFH HEPH	3.79e-03	20	136	2	DOID:1686 (is_marker_for)
Disease	response to COVID-19 vaccine, SARS-CoV-2 neutralizing antibody measurement	FAM209B GSG1L	3.79e-03	20	136	2	EFO_0803359, EFO_0803362
Disease	androsterone glucuronide measurement	UGT2B15 UGT2B17	3.79e-03	20	136	2	EFO_0800317
Disease	Cocaine Dependence	GAD1 DRD3 SMAD1 SMAD5	3.98e-03	139	136	4	C0600427
Disease	Retinal Degeneration	PDE6B IFT80	4.18e-03	21	136	2	C0035304
Disease	Seckel syndrome	WDR4 ATR	4.59e-03	22	136	2	C0265202
Disease	X-24947 measurement	UGT2B15 UGT2B17	4.59e-03	22	136	2	EFO_0800910

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGSYWCVCHQEAPAT	UMODL1	286	Q5DID0
INGTTDPHCASWDYS	ADGRB2	866	O60241
RLVTDPDSGLCSHYW	AFDN	801	P55196
PDSGLCSHYWGAIIR	AFDN	806	P55196
PYHVTICEIWGEESS	FAM209A	156	Q5JX71
LSIDSCWVGSFYCPH	CATSPERG	276	Q6ZRH7
PYHTVWDCDFSTGKI	ACSS1	86	Q9NUB1
WYSIAHPSVICTDDK	ADAL	281	Q6DHV7
WTPTSDLYIGCEEGH	CFAP43	261	Q8NDM7
EFWCDTIHTGVYPIL	AIPL1	86	Q9NZN9
HPYPHSRDCDWTITV	CSMD3	1606	Q7Z407
ICTPHAAWYSEQASI	CTBP1	311	Q13363
LICTPHTAWYSEQAS	CTBP2	316	P56545
PQYCGSCWAHASTSA	CTSZ	86	Q9UBR2
ICTSAASYPGVFEWD	C2orf78	116	A6NCI8
WHDVSVYLGLTNCPS	CCDC62	461	Q6P9F0
PGCTLWEAYANLHTA	BMX	141	P51813
FHTGIWYSCEEELSG	GSG1L	101	Q6UXU4
HVYCDVISGSPWTLI	ANGPTL3	271	Q9Y5C1
YGGISDCWADRSPLH	ASB11	56	Q8WXH4
FETPSGSYWDHIHCT	CFH	361	P08603
CVSWHPTIYGLIAVS	DNAI3	341	Q8IWG1
CLLYGGDCSHWTESI	DMXL1	276	Q9Y485
DHLSHYSPWSCGTIG	RC3H2	831	Q9HBD1
PGDVIGYVVDWCDHT	OSMR	551	Q99650
AVLECDGHTYSLRWP	PALD1	551	Q9ULE6
SWLPFAIYCVVGSHE	GPR6	291	P46095
CYEFLWGPRAHAETS	MAGEA11	381	P43364
VSCHSDGSYCQWPVS	LLGL2	246	Q6P1M3
DGSDWFCYHATSPSI	MBTD1	426	Q05BQ5
PGWYSNTHLCDLNST	GPR179	286	Q6PRD1
GPSTDGLDWFCYHAS	L3MBTL2	466	Q969R5
DGLGTWHPYSATVCS	DTX2	26	Q86UW9
AHSACVTAAGDLYTW	HERC2	4101	O95714
PLTLNHEGYWEGSCS	KY	616	Q8NBH2
AGHCPEWTVVFDLSA	GDF1	121	P27539
DPHDCSAYTGWTGIA	LANCL2	96	Q9NS86
WASPAVTSLESAACH	BEND2	181	Q8NDZ0
PTTYDTWCGVAHGCT	GAD1	26	Q99259
ESSHSWLSGPLCVMY	OR51I2	21	Q9H344
YSTDTHWFSGPRCEV	MUC3A	3206	Q02505
DHWALASGLPSYVAE	PDE6B	336	P35913
PYHVTICKIWGEESS	FAM209B	156	Q5JX69
WAPEDHRYITVSGCL	NKAIN2	126	Q5VXU1
SCYLGDHISDGAWDP	LMLN2	66	A0A1B0GTW7
DEDHSGPWCATTLNY	LY75	186	O60449
RPEGYWSDCGTQSAH	LGR4	891	Q9BXB1
CYGAHNLSSEWSAPS	LILRA6	296	Q6PI73
CYGAHNLSSEWSAPS	LILRB3	296	O75022
RFSCWYDADLSPAGH	PGAM4	21	Q8N0Y7
SDCYVTLWLPTACSH	PLA2G4B	31	P0C869
SGWEHVSRSDACVLY	PSMB11	231	A5LHX3
IDLSEGISQHAWYPC	PAPPA	1056	Q13219
WTAPSFCAEHAYSSA	KDM5A	1391	P29375
HYQTIQEAGDWCVPS	PDK2	381	Q15119
SPGTNCAEAYHSWAD	IFT172	1491	Q9UG01
CLQHSYAGAWAVSPE	ICOSLG	281	O75144
HLCGDTNYAWPTAEI	PCCB	446	P05166
WVFDSYSLTGPSVCE	GATD1	141	Q8NB37
CGMLSLPWIYSHSDD	ATR	591	Q13535
QDSGTYSCHVEEWLP	IGSF3	911	O75054
GTYHCTAAEWIQDPD	IGSF8	266	Q969P0
GWTTAEELYSCSDDH	IFT80	21	Q9P2H3
RTHTGEKPYACTWEG	KLF1	301	Q13351
PHQTDSWIGSAYVDL	C2CD3	1506	Q4AC94
DHYVATTEFLWSVPC	CENPL	231	Q8N0S6
TSHTLPDSLVYGADW	DPH7	326	Q9BTV6
TWQPSAGATHYLVRC	COL20A1	486	Q9P218
ECQAWGDPHYVTLDG	FCGBP	2071	Q9Y6R7
AECQAWGDPHYVTLD	FCGBP	3271	Q9Y6R7
TAECQAWGDPHYVTL	FCGBP	4471	Q9Y6R7
QIPTASEDHSGSYWC	FCRLA	226	Q7L513
HPDLALAGDWIYCIT	CACNA2D4	676	Q7Z3S7
SGPVCTHYTQVVWAT	CRISPLD1	161	Q9H336
GEELPSCGQHYWETT	CMYA5	3936	Q8N3K9
SCGQHYWETTVTDCP	CMYA5	3941	Q8N3K9
PYGSHRETQTECEWT	DSP	1946	P15924
IFSSVCYWTLGLHPE	ABCG5	481	Q9H222
IVCGEDGWSHLPTCY	CFHR4	191	Q92496
DGWSHLPTCYNSSEN	CFHR4	196	Q92496
ECSWQYEGPTAGVSH	IL12RB1	61	P42701
GELFDHGLDSWSCVY	SELENOI	121	Q9C0D9
WSPEVPSTLEVYSCH	IL21R	306	Q9HBE5
CKGASSYITHIDWDS	EML6	1121	Q6ZMW3
TYFAWCPDGEHILTA	EIF2A	361	Q9BY44
GCYADGTWELSVHVT	FERMT2	11	Q96AC1
HPASLYSWEDGDCSH	GUSBP1	71	Q15486
YSWEDGDCSHQSLGP	GUSBP1	76	Q15486
SDNEWSVPHCFTIYA	FARP2	811	O94887
VPCSQGWEYDHSEFS	SLC22A7	111	Q9Y694
ACVRDYHTFVWSSVP	CALCOCO1	56	Q9P1Z2
HCGHCPEEWITYSNS	KLRC4	116	O43908
DDPGATLRYHWECAT	PKD1L1	811	Q8TDX9
TLRYHWECATAGSPA	PKD1L1	816	Q8TDX9
FEHPETLYAWEGACV	CD22	26	P20273
ILPWHAGTYSCVAEN	CD22	386	P20273
QTCHVSPELYSATTW	DRD3	356	P35462
AIECHSPYTSPAAHW	FOXF2	326	Q12947
IPGSIFSSDLYDHWV	ARHGAP20	441	Q9P2F6
WPGYTLETANTQCHE	RGMB	346	Q6NW40
IVAHAEAASWYSCGP	CARS2	66	Q9HA77
EAASWYSCGPTVYDH	CARS2	71	Q9HA77
YERCWSHSNEESFSP	SEL1L3	1026	Q68CR1
DLIDSYPGHETLWCH	PTAR1	301	Q7Z6K3
SYTHCIWRVSVTPGE	TLL1	371	O43897
RCYGAHNLSSEWSAP	LILRB1	296	Q8NHL6
GLWFHPEELVDYTSC	NME1	131	P15531
LPADVEHGYSWSIFC	TMEM178A	246	Q8NBL3
ICYGHASSCPWDETT	LAMA1	271	P25391
SLPEVSFADSAWHCV	NBEAL2	666	Q6ZNJ1
HAPTDADPACLTWIY	HEPH	171	Q9BQS7
ADPACLTWIYHSHVD	HEPH	176	Q9BQS7
VGRDTLPEHWSYGVC	PLEKHA7	6	Q6IQ23
STLPASGECQWHYAN	SIM2	481	Q14190
KGIDHSCPASSEFSW	SPATA31D4	341	Q6ZUB0
IWSEDGCIYPATIAS	SMN1	101	Q16637
LQGSTPCVHSVWYSI	PKHD1	926	P08F94
PCVHSVWYSIDGDIN	PKHD1	931	P08F94
PTEAEWEYSCRGGLH	SUMF1	226	Q8NBK3
PYDHTADLWSVGCIL	STK36	176	Q9NRP7
GAEYHRQDVTSTPCW	SMAD5	421	Q99717
GAEYHRQDVTSTPCW	SMAD1	421	Q15797
CHSSVYIWPSSDINT	UFSP2	56	Q9NUQ7
CAGACPYLWSSDTQH	TGFB2	346	P61812
GHGSDYSLSEVLWVC	XRCC6	136	P12956
KGIDHSCPASSEFSW	SPATA31D3	341	P0C874
ESPDHLGYWTVCELL	TICRR	221	Q7Z2Z1
PVSLNHSGAYVCWAA	TMIGD2	101	Q96BF3
HSGAYVCWAAVEIPE	TMIGD2	106	Q96BF3
SPAACEERHGAFWSY	ZFHX2	196	Q9C0A1
VLYGWTDHSACSPVC	VWF	281	P04275
ISDLHYLSPSGCTFW	RNF19A	336	Q9NV58
LAIPGSHDSFSYWVD	PLCXD2	51	Q0VAA5
EYITPCHAGCSSWVV	SLCO2B1	511	O94956
PGAIHYCASTSEESW	SPDEF	221	O95238
WHPTCGRISYTDAEG	WDHD1	281	O75717
GDYHCFHSPTDWTVS	PISD	261	Q9UG56
HCEGTESYLWNCPVS	SCART1	396	Q4G0T1
ACWSDSPGQHYFSSL	SH2B2	536	O14492
HLPQAAWSDAGVYTC	SIGLEC1	291	Q9BZZ2
CQVHTGVPEGTSYRW	SIGLEC1	916	Q9BZZ2
RWSDYTLHLPTGSDV	TMEM168	621	Q9H0V1
QHASWDPLPCTTDSY	ZC3H12B	726	Q5HYM0
RCSPKSGHDTVSWYQ	TRBV5-6	41	A0A599
SCTVGVWAAYDPVHK	ZFYVE1	216	Q9HBF4
DAIGLHWDVYPSSCS	ZG16	151	O60844
SHCAVYADDWVTDPR	SRD5A1	136	P18405
AWDGASCTHYRPSLG	SEMA3G	541	Q9NS98
VSWAAAPHSIESFCL	WDR4	171	P57081
ESPVCTSGWYHLAEA	TTC37	301	Q6PGP7
ATLGFWCEAEHEAPS	ZNF304	51	Q9HCX3
GSCGKVLVWPTEYSH	UGT2B15	21	P54855
DHKVSIDCPWSIYST	TRAPPC10	921	P48553
YCRSPGTGEWHTFND	USP2	561	O75604
YPILDTCWHERGSNS	TRIM50	451	Q86XT4
GSCGKVLVWPTEYSH	UGT2B17	21	O75795
CSWHLTVPSLDYGLA	TMPRSS6	366	Q8IU80
IPLGHSCQWTAALYS	UBASH3A	256	P57075
YHWPLTATCRAGSQE	KIAA1958	56	Q8N8K9