Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DNAH6 DNAH11	7.11e-05	18	91	3	GO:0008569
GeneOntologyMolecularFunction	ATP-dependent activity	DNHD1 IPO8 SPG7 ABCA13 CHTF18 DDX42 SMARCA2 DNAH6 ABCA7 SNRNP200 DNAH11	1.08e-04	614	91	11	GO:0140657
GeneOntologyMolecularFunction	protein serine kinase activity	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	2.53e-04	363	91	8	GO:0106310
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 DNAH6 DNAH11	2.76e-04	28	91	3	GO:0051959
GeneOntologyMolecularFunction	protein kinase activity	ULK3 STK36 DDR2 SIK2 ELP1 DAPK1 MAPK3 CDK14 PSKH2 CDK5	4.02e-04	600	91	10	GO:0004672
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNHD1 DNAH6 DNAH11	6.36e-04	37	91	3	GO:0045505
GeneOntologyMolecularFunction	ATP hydrolysis activity	SPG7 ABCA13 CHTF18 DDX42 DNAH6 ABCA7 SNRNP200 DNAH11	9.11e-04	441	91	8	GO:0016887
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	9.80e-04	446	91	8	GO:0004674
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ULK3 STK36 DDR2 SIK2 ELP1 DAPK1 MAPK3 CDK14 PSKH2 CDK5	1.44e-03	709	91	10	GO:0016773
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	NRIP1 PRAMEF19 PRAMEF18	2.02e-03	55	91	3	GO:0042974
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARHGAP5 ARHGAP40 RALGAPB TBC1D14 RASGEF1C PLEKHG2 ARHGAP45 VAV1	2.20e-03	507	91	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ARHGAP5 ARHGAP40 RALGAPB TBC1D14 RASGEF1C PLEKHG2 ARHGAP45 VAV1	2.20e-03	507	91	8	GO:0030695
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	6.62e-06	9	90	3	GO:0160063
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO2 NOMO3 NOMO1	6.58e-06	9	91	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO2 NOMO3 NOMO1	2.81e-05	14	91	3	GO:0072379
Domain	-	LRRC8C PODNL1 MFHAS1 PRAMEF19 LGI3 TONSL PHLPP1 SLITRK3 CHADL PRAMEF18 TLR8 FBXL4 PHLPP2	6.78e-09	321	93	13	3.80.10.10
Domain	L_dom-like	LRRC8C PODNL1 MFHAS1 PRAMEF19 LGI3 TONSL PHLPP1 SLITRK3 CHADL PRAMEF18 TLR8 FBXL4 PHLPP2	8.77e-09	328	93	13	IPR032675
Domain	Leu-rich_rpt	LRRC8C PODNL1 MFHAS1 LGI3 TONSL PHLPP1 SLITRK3 CHADL TLR8 FBXL4 PHLPP2	1.04e-07	271	93	11	IPR001611
Domain	LRR_1	LRRC8C PODNL1 MFHAS1 LGI3 PHLPP1 SLITRK3 CHADL TLR8 FBXL4 PHLPP2	1.38e-07	219	93	10	PF00560
Domain	LRR_8	LRRC8C PODNL1 MFHAS1 LGI3 PHLPP1 SLITRK3 CHADL TLR8 PHLPP2	1.82e-07	171	93	9	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC8C PODNL1 MFHAS1 LGI3 PHLPP1 SLITRK3 CHADL TLR8 PHLPP2	2.44e-07	177	93	9	IPR003591
Domain	LRR_TYP	LRRC8C PODNL1 MFHAS1 LGI3 PHLPP1 SLITRK3 CHADL TLR8 PHLPP2	2.44e-07	177	93	9	SM00369
Domain	DUF2012	NOMO2 NOMO3 NOMO1	4.76e-07	4	93	3	PF09430
Domain	DUF2012	NOMO2 NOMO3 NOMO1	4.76e-07	4	93	3	IPR019008
Domain	Carb-bd-like_fold	NOMO2 NOMO3 NOMO1	6.57e-06	8	93	3	IPR013784
Domain	LRR	LRRC8C PODNL1 MFHAS1 LGI3 PHLPP1 CHADL TLR8 PHLPP2	7.29e-06	201	93	8	PS51450
Domain	AAA+_ATPase	SPG7 ABCA13 CHTF18 DNAH6 ABCA7 SNRNP200 DNAH11	7.62e-06	144	93	7	IPR003593
Domain	AAA	SPG7 ABCA13 CHTF18 DNAH6 ABCA7 SNRNP200 DNAH11	7.62e-06	144	93	7	SM00382
Domain	CarboxyPept_regulatory_dom	NOMO2 NOMO3 NOMO1	3.30e-05	13	93	3	IPR014766
Domain	-	NOMO2 NOMO3 NOMO1	3.30e-05	13	93	3	2.60.40.1120
Domain	Dynein_HC_stalk	DNHD1 DNAH6 DNAH11	4.18e-05	14	93	3	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH6 DNAH11	4.18e-05	14	93	3	IPR013602
Domain	DHC_N2	DNHD1 DNAH6 DNAH11	4.18e-05	14	93	3	PF08393
Domain	MT	DNHD1 DNAH6 DNAH11	4.18e-05	14	93	3	PF12777
Domain	DHC_fam	DNHD1 DNAH6 DNAH11	5.21e-05	15	93	3	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH6 DNAH11	5.21e-05	15	93	3	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH6 DNAH11	5.21e-05	15	93	3	PF03028
Domain	ALMS_motif	ALMS1 CEP295	7.33e-05	3	93	2	IPR029299
Domain	ALMS_motif	ALMS1 CEP295	7.33e-05	3	93	2	PF15309
Domain	CarboxyPept-like_regulatory	NOMO2 NOMO3 NOMO1	7.73e-05	17	93	3	IPR008969
Domain	ROC_dom	MFHAS1 DAPK1	1.46e-04	4	93	2	IPR020859
Domain	ROC	MFHAS1 DAPK1	1.46e-04	4	93	2	PS51424
Domain	PH_dom-like	PLCH2 PHLPP1 BBS5 PLD1 PLEKHG2 FERMT2 LYST VAV1 PHLPP2	2.72e-04	426	93	9	IPR011993
Domain	P-loop_NTPase	DNHD1 ARHGAP5 SPG7 ABCA13 MFHAS1 CHTF18 DDX42 SMARCA2 DAPK1 DNAH6 ABCA7 SNRNP200 DNAH11	2.86e-04	848	93	13	IPR027417
Domain	-	DNHD1 ARHGAP5 SPG7 ABCA13 MFHAS1 CHTF18 DDX42 SMARCA2 DNAH6 ABCA7 SNRNP200 DNAH11	3.24e-04	746	93	12	3.40.50.300
Domain	Ser/Thr_kinase_AS	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	4.09e-04	357	93	8	IPR008271
Domain	S_TKc	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	4.24e-04	359	93	8	SM00220
Domain	PROTEIN_KINASE_ST	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	4.48e-04	362	93	8	PS00108
Domain	PH	TEX2 PLCH2 PHLPP1 PLD1 PLEKHG2 FERMT2 VAV1	4.78e-04	278	93	7	SM00233
Domain	PH_DOMAIN	PLCH2 PHLPP1 PLD1 PLEKHG2 FERMT2 VAV1 PHLPP2	4.88e-04	279	93	7	PS50003
Domain	PH_domain	TEX2 PLCH2 PHLPP1 PLD1 PLEKHG2 FERMT2 VAV1	4.99e-04	280	93	7	IPR001849
Domain	Protein_kinase_ATP_BS	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	6.06e-04	379	93	8	IPR017441
Domain	Pkinase	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	6.27e-04	381	93	8	PF00069
Domain	Prot_kinase_dom	ULK3 STK36 DDR2 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	7.37e-04	489	93	9	IPR000719
Domain	-	PLCH2 PHLPP1 BBS5 PLD1 PLEKHG2 FERMT2 VAV1 PHLPP2	7.43e-04	391	93	8	2.30.29.30
Domain	PROTEIN_KINASE_DOM	ULK3 STK36 DDR2 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	7.81e-04	493	93	9	PS50011
Domain	PH	PLCH2 PHLPP1 PLD1 PLEKHG2 FERMT2 VAV1	9.98e-04	229	93	6	PF00169
Domain	Cys-rich_flank_reg_C	LGI3 SLITRK3 CHADL TLR8	1.06e-03	90	93	4	IPR000483
Domain	LRRCT	LGI3 SLITRK3 CHADL TLR8	1.06e-03	90	93	4	SM00082
Domain	Kinase-like_dom	ULK3 STK36 DDR2 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	1.51e-03	542	93	9	IPR011009
Domain	ABC_A	ABCA13 ABCA7	1.57e-03	12	93	2	IPR026082
Domain	PROTEIN_KINASE_ATP	ULK3 STK36 SIK2 DAPK1 MAPK3 CDK14 PSKH2 CDK5	2.06e-03	459	93	8	PS00107
Domain	Dynein_heavy_chain_D4_dom	DNAH6 DNAH11	2.15e-03	14	93	2	IPR024317
Domain	IMPORTIN_B_NT	IPO8 IPO13	2.15e-03	14	93	2	PS50166
Domain	AAA_8	DNAH6 DNAH11	2.15e-03	14	93	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH6 DNAH11	2.15e-03	14	93	2	IPR011704
Domain	AAA_5	DNAH6 DNAH11	2.15e-03	14	93	2	PF07728
Domain	IBN_N	IPO8 IPO13	2.47e-03	15	93	2	PF03810
Domain	IBN_N	IPO8 IPO13	2.81e-03	16	93	2	SM00913
Domain	Importin-beta_N	IPO8 IPO13	3.18e-03	17	93	2	IPR001494
Domain	PP2C	PHLPP1 PHLPP2	3.97e-03	19	93	2	PF00481
Domain	PRAME_family	PRAMEF19 PRAMEF18	3.97e-03	19	93	2	IPR026271
Domain	PP2Cc	PHLPP1 PHLPP2	4.40e-03	20	93	2	SM00332
Domain	PPM-type_phosphatase_dom	PHLPP1 PHLPP2	4.40e-03	20	93	2	IPR001932
Domain	-	PHLPP1 PHLPP2	4.40e-03	20	93	2	3.60.40.10
Domain	PPM_2	PHLPP1 PHLPP2	4.40e-03	20	93	2	PS51746
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	ULK3 SIK2 PSKH2	4.94e-03	69	93	3	IPR020636
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP5 ARHGAP40 TEX2 PLD1 ARHGAP45 VAV1	6.23e-05	149	65	6	M41805
Pathway	BIOCARTA_RAC1_PATHWAY	PLD1 VAV1 CDK5	1.17e-04	21	65	3	M8601
Pathway	BIOCARTA_RAC1_PATHWAY	PLD1 VAV1 CDK5	1.17e-04	21	65	3	MM1463
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP5 PLD1 PLEKHG2 FERMT2 ARHGAP45 VAV1	1.99e-04	184	65	6	M41809
Pathway	REACTOME_RHO_GTPASE_CYCLE	ARHGAP5 ARHGAP40 TEX2 SLITRK3 PLD1 PLEKHG2 FERMT2 ARHGAP45 VAV1	2.08e-04	450	65	9	M27078
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO2 NOMO3 NOMO1	1.91e-08	3	94	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO2 NOMO3 NOMO1	1.91e-08	3	94	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO2 NOMO3 NOMO1	7.63e-08	4	94	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO2 NOMO3 NOMO1	7.63e-08	4	94	3	9267806
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO2 NOMO3 NOMO1	1.06e-06	8	94	3	15257293
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TGM4 ARHGAP5 SPG7 TEX2 UBP1 PRAMEF19 DDX42 EXOC3L1 TMEM131 CEP295 PLD1 PRAMEF18 FERMT2 DSE	1.29e-06	1084	94	14	11544199
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO2 NOMO3 NOMO1	1.59e-06	9	94	3	36261522
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNHD1 SELENOV NOP9 ALMS1 PPP6R1 MAPK3 SNRNP200 NOMO3 CDK5 LGALS8 NOMO1	2.03e-06	670	94	11	22990118
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO2 NOMO3 NOMO1	3.11e-06	11	94	3	32820719
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	TRIM72 NOMO2 NOMO3 PHLPP2 NOMO1	4.75e-06	90	94	5	15616553
Pubmed	Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene.	ARHGAP45 ABCA7	7.23e-06	2	94	2	11095984
Pubmed	Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.	PHLPP1 PHLPP2	7.23e-06	2	94	2	24892992
Pubmed	Enhanced diacylglycerol production by phospholipase D activation is responsible for abnormal increase in concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mice.	PLD1 LYST	7.23e-06	2	94	2	24830864
Pubmed	PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble.	PHLPP1 PHLPP2	7.23e-06	2	94	2	36376971
Pubmed	PHLPPing through history: a decade in the life of PHLPP phosphatases.	PHLPP1 PHLPP2	7.23e-06	2	94	2	27913677
Pubmed	Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma.	PHLPP1 PHLPP2	7.23e-06	2	94	2	25793736
Pubmed	Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma.	PHLPP1 PHLPP2	7.23e-06	2	94	2	38602289
Pubmed	Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators.	PHLPP1 PHLPP2	7.23e-06	2	94	2	22183406
Pubmed	Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome.	ARHGAP45 ABCA7	7.23e-06	2	94	2	15593299
Pubmed	ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits.	ALMS1 CEP295	7.23e-06	2	94	2	30421101
Pubmed	Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.	PHLPP1 PHLPP2	7.23e-06	2	94	2	26187040
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NRIP1 HIVEP1 TMTC3 UBP1 SMARCA2 ELP1 CEP295 ARHGAP45 NOMO3 DNAH11	9.12e-06	638	94	10	31182584
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	NOMO2 CDK14 FERMT2 NOMO3 NOMO1	1.27e-05	110	94	5	27889896
Pubmed	Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer.	PHLPP1 PHLPP2	2.16e-05	3	94	2	34663797
Pubmed	Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis.	PHLPP1 PHLPP2	2.16e-05	3	94	2	20513427
Pubmed	Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.	PHLPP1 PHLPP2	2.16e-05	3	94	2	27760826
Pubmed	PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells.	PHLPP1 PHLPP2	2.16e-05	3	94	2	32294598
Pubmed	Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma.	PHLPP1 PHLPP2	2.16e-05	3	94	2	26245343
Pubmed	microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2.	PHLPP1 PHLPP2	2.16e-05	3	94	2	23846336
Pubmed	The identification and characterization of expression of Pftaire-1, a novel Cdk family member, suggest its function in the mouse testis and nervous system.	CDK14 CDK5	2.16e-05	3	94	2	9547506
Pubmed	The phosphatase PHLPP controls the cellular levels of protein kinase C.	PHLPP1 PHLPP2	2.16e-05	3	94	2	18162466
Pubmed	PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.	PHLPP1 PHLPP2	2.16e-05	3	94	2	17386267
Pubmed	Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731.	ALMS1 CEP295	2.16e-05	3	94	2	20844083
Pubmed	Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake.	PLD1 MAPK3	2.16e-05	3	94	2	20231899
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF19 PRAMEF18	2.16e-05	3	94	2	21347312
Pubmed	Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP.	ARHGAP5 CDK5	2.16e-05	3	94	2	19822667
Pubmed	MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2.	PHLPP1 PHLPP2	2.16e-05	3	94	2	24945731
Pubmed	Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.	PHLPP1 PHLPP2	2.16e-05	3	94	2	34348155
Pubmed	SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases.	SIK2 PHLPP2	2.16e-05	3	94	2	33128264
Pubmed	Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL.	PHLPP1 PHLPP2	4.32e-05	4	94	2	26427440
Pubmed	Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells.	PLD1 MAPK3	4.32e-05	4	94	2	20693286
Pubmed	Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.	ARHGAP45 ABCA7	4.32e-05	4	94	2	23571587
Pubmed	A novel cdc2-related protein kinase expressed in the nervous system.	CDK14 CDK5	4.32e-05	4	94	2	9202329
Pubmed	PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth.	PHLPP1 PHLPP2	4.32e-05	4	94	2	21986499
Pubmed	PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.	PHLPP1 PHLPP2	4.32e-05	4	94	2	21804599
Pubmed	Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.	DAPK1 MAPK3	4.32e-05	4	94	2	15616583
Pubmed	PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.	PHLPP1 PHLPP2	4.32e-05	4	94	2	24530606
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IPO8 TMTC3 NOMO2 TEX2 RALGAPB DDX42 PWP2 SIK2 ELP1 TMEM131 PPP6R1 FERMT2 SNRNP200 NOMO1	4.55e-05	1487	94	14	33957083
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMYD4 NOP9 CHTF18 RALGAPB TONSL SIK2 ELP1 PPP6R1 FHIP2A	6.82e-05	650	94	9	38777146
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF19 PRAMEF18	7.19e-05	5	94	2	16159394
Pubmed	Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway.	MAPK3 CDK5	7.19e-05	5	94	2	12491158
Pubmed	CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression.	PLD1 MAPK3	7.19e-05	5	94	2	17627030
Pubmed	Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts.	DDR2 MAPK3	7.19e-05	5	94	2	21335558
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO2 NOMO3 NOMO1	8.14e-05	31	94	3	19136429
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO2 NOMO3 NOMO1	9.84e-05	33	94	3	30783098
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ARHGAP5 IPO8 ALMS1 NOMO2 TMEM131 CEP295 PLEKHG2 AP4M1 FERMT2 FHIP2A	1.05e-04	853	94	10	28718761
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	NRIP1 HIVEP1 UBP1 NCKIPSD PWP2 SMARCA2 CDK5	1.06e-04	398	94	7	35016035
Pubmed	FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages.	FANCC TLR8	1.08e-04	6	94	2	24046015
Pubmed	Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion.	NCKIPSD MAPK3	1.08e-04	6	94	2	14559906
Pubmed	Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.	PHLPP1 PHLPP2	1.08e-04	6	94	2	25216524
Pubmed	FANCI is a negative regulator of Akt activation.	PHLPP1 PHLPP2	1.08e-04	6	94	2	27097374
Pubmed	DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway.	DDR2 MAPK3	1.08e-04	6	94	2	25733533
Pubmed	Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.	ULK3 STK36	1.08e-04	6	94	2	31279575
Pubmed	Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts.	PLD1 MAPK3	1.08e-04	6	94	2	12782152
Pubmed	Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.	PHLPP1 PHLPP2	1.50e-04	7	94	2	19261608
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TEX2 ZFHX2 CEP295 DNAH6	1.74e-04	102	94	4	11214970
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ULK3 NOMO2 DDR2 SIK2 MAPK3 CDK14 LYST NOMO3 CDK5 NOMO1	1.78e-04	910	94	10	36736316
Pubmed	TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.	FANCC TLR8	2.00e-04	8	94	2	19850743
Pubmed	The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.	MAPK3 CDK5	2.00e-04	8	94	2	9614189
Pubmed	N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma.	ARHGAP5 MAPK3	2.00e-04	8	94	2	36354136
Pubmed	The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.	PHLPP1 PHLPP2	2.00e-04	8	94	2	27463890
Pubmed	Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice.	MAPK3 CDK5	2.00e-04	8	94	2	28064242
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	IPO8 SPG7 NOMO2 ELP1 TMEM131 PPP6R1 NOMO3 NOMO1	2.43e-04	606	94	8	36538041
Pubmed	Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.	PHLPP1 PHLPP2	2.57e-04	9	94	2	20605778
Pubmed	Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?	FANCC ELP1	2.57e-04	9	94	2	18264947
Pubmed	Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.	MAPK3 CDK5	3.21e-04	10	94	2	8444355
Pubmed	Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum.	MAPK3 CDK5	3.21e-04	10	94	2	27480591
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALMS1 RALGAPB SIK2 PHLPP1 SNRNP200	3.73e-04	225	94	5	12168954
Pubmed	Genomic analysis of mouse retinal development.	FANCC SPG7 NOMO2 LGI3 TONSL ADGRG1 GREB1 NOMO3 PHLPP2 NOMO1	3.95e-04	1006	94	10	15226823
Pubmed	Proteomic analysis of in vivo phosphorylated synaptic proteins.	LRRC8C MAPK3 CDK5	4.06e-04	53	94	3	15572359
Pubmed	Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury.	TRIM72 CDK5	4.69e-04	12	94	2	36337049
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ARHGAP5 LGI3 DLGAP4 NCKIPSD ELP1 DAPK1 MAPK3 FERMT2 DNAH6 SNRNP200 CDK5 DNAH11	4.76e-04	1431	94	12	37142655
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	UBP1 TBC1D14 NCKIPSD PWP2 SIK2 PPP6R1 AP4M1 FERMT2 FHIP2A FBXL4	5.04e-04	1038	94	10	26673895
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF19 MAPK3 PRAMEF18	5.30e-04	58	94	3	31598710
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIVEP1 ALMS1 TEX2 RALGAPB NCKIPSD SIK2 PLEKHG2 CDK14 LYST	5.46e-04	861	94	9	36931259
Pubmed	RhoG signals in parallel with Rac1 and Cdc42.	PLD1 VAV1	5.53e-04	13	94	2	12376551
Pubmed	The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.	MAPK3 CDK5	5.53e-04	13	94	2	17906618
Pubmed	USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.	PHLPP1 PHLPP2	5.53e-04	13	94	2	28363942
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	LYST LGALS8	6.44e-04	14	94	2	11472062
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH6 DNAH11	6.44e-04	14	94	2	9373155
Pubmed	Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.	NOMO2 NOMO3 NOMO1	6.75e-04	63	94	3	31266804
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	HIVEP1 UBP1 DLGAP4 NCKIPSD SMARCA2 IPO13 NOMO1	8.27e-04	560	94	7	21653829
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ALMS1 TMTC3 NOMO2 TEX2 DDX42 MFSD9 TMEM131 CEP295	8.49e-04	733	94	8	34672954
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LRRC8C ARHGAP5 ZNF592 TBC1D14 CEP295 PPP6R1 SNRNP200 DSE	8.71e-04	736	94	8	29676528
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	SPG7 NOMO2 DLGAP4 TONSL TBC1D14 ELP1 PPP6R1 MAPK3 VAV1 CDK5	9.27e-04	1124	94	10	21900206
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF19 PRAMEF18	9.57e-04	17	94	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF19 PRAMEF18	9.57e-04	17	94	2	37781892
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ARHGAP5 DLGAP4 RALGAPB FERMT2 CDK5 NOMO1	1.01e-03	421	94	6	36976175
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF19 PRAMEF18	1.08e-03	18	94	2	23894331
Pubmed	Functional screen identifies regulators of murine hematopoietic stem cell repopulation.	SMARCA2 ADGRG1	1.08e-03	18	94	2	26880577
Cytoband	20q11.23	ARHGAP40 DLGAP4 RALGAPB	6.14e-05	37	94	3	20q11.23
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLPP1 PLD1 PLEKHG2 FERMT2 VAV1 PHLPP2	3.33e-05	206	54	6	682
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP5 ARHGAP40 ARHGAP45	4.47e-04	50	54	3	721
GeneFamily	ATP binding cassette subfamily A	ABCA13 ABCA7	7.79e-04	14	54	2	805
GeneFamily	Dyneins, axonemal	DNAH6 DNAH11	1.16e-03	17	54	2	536
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PHLPP1 PHLPP2	1.16e-03	17	54	2	701
GeneFamily	Armadillo repeat containing\|Importins	IPO8 IPO13	1.30e-03	18	54	2	596
GeneFamily	PRAME family	PRAMEF19 PRAMEF18	2.32e-03	24	54	2	686
GeneFamily	Cyclin dependent kinases	CDK14 CDK5	2.72e-03	26	54	2	496
GeneFamily	Phospholipases	PLCH2 PLD1	6.98e-03	42	54	2	467
GeneFamily	AAA ATPases	SPG7 CHTF18	1.09e-02	53	54	2	413
Computational	Neighborhood of SUPT4H1	FANCC MAPK3 LYST VAV1	1.35e-04	58	49	4	GCM_SUPT4H1
Computational	Neighborhood of FANCC	FANCC HIVEP1 MAPK3 LYST VAV1	2.58e-04	126	49	5	GCM_FANCC
Disease	Spastic Paraplegia	SPG7 LYST	3.05e-04	9	87	2	C0037772
Disease	Ashkenazi Jewish disorders	FANCC ELP1	4.65e-04	11	87	2	cv:CN118946
Disease	focal segmental glomerulosclerosis	ALMS1 DNAH6	1.00e-03	16	87	2	EFO_0004236
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	DDR2 CEP295 GREB1	1.22e-03	71	87	3	EFO_0004735, EFO_0007965
Disease	Phenyllactate (PLA) measurement	IPO8 DAPK1	1.42e-03	19	87	2	EFO_0021662
Disease	neutrophil percentage of leukocytes	ULK3 HIVEP1 TMTC3 TBC1D14 TMEM131 ARHGAP45 ABCA7	2.19e-03	610	87	7	EFO_0007990
Disease	lissencephaly (implicated_via_orthology)	CDK14 CDK5	2.88e-03	27	87	2	DOID:0050453 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QHKQLQALSHLLPRL	EXOC3L1	126	Q86VI1
PSLRQLKQQAFLLHF	CHTF18	496	Q8WVB6
TQNLQPRIKLKLFGH	DAPK1	681	P53355
LIQNKQLRLLPQEHV	BBS5	146	Q8N3I7
KQLLRHPAFQLLLAL	CATSPER4	86	Q7RTX7
HPAFQLLLALLLVIN	CATSPER4	91	Q7RTX7
ANQQKLLPQFLLHLD	CARNMT1	96	Q8N4J0
NVLHRDLKPQNLLIN	CDK5	121	Q00535
RLAKILQNPITHSLQ	ALMS1	3631	Q8TCU4
NKNFRLILHTKLANP	DNAH11	3576	Q96DT5
PTHNVARLILNLFKN	ABCA13	1201	Q86UQ4
YILHRDLKPQNLLIS	CDK14	251	O94921
AHKQLPSTLFLRLLQ	DNHD1	3021	Q96M86
HAQATKINRLPANLL	DLGAP4	91	Q9Y2H0
LFTLLLQHRSQLLPQ	ABCA7	1746	Q8IZY2
LLSKSQALNVRLHLP	AP4M1	321	O00189
NHDKLIPLLLQLTSR	NOMO3	1176	P69849
LQVALQVLHRKLPQF	NOP9	281	Q86U38
NHDKLIPLLLQLTSR	NOMO2	1176	Q5JPE7
ALQITHRNLKPENLL	PSKH2	176	Q96QS6
PHDISNVLKLYLRQL	ARHGAP45	826	Q92619
LAAPAQLLLEKFLQH	GREB1	1806	Q4ZG55
ELRKLNLSHNQLPAL	MFHAS1	136	Q9Y4C4
QYLLNHRLQILSPVL	MFHAS1	611	Q9Y4C4
PILRLYKHNSQALLL	MFSD9	341	Q8NBP5
IALHLNPRLNIKAFV	LGALS8	226	O00214
TKNRPSFQEIHLLLL	DDR2	836	Q16832
NLTPQQLIDLRHKLN	DDX42	226	Q86XP3
LLVNQHLSLLARKFP	PDCL2	126	Q8N4E4
VPSQNLHLTLALLRL	LENG9	356	Q96B70
QLKQLNLSHGALRFI	PRAMEF18	321	Q5VWM3
NHDKLIPLLLQLTSR	NOMO1	1176	Q15155
NNSLLLHLLKSQTIP	NRIP1	376	P48552
LKNVQRNLILLHPQL	DSE	551	Q9UL01
RKLRINLNLIYDHNP	ELP1	746	O95163
NVLHRDLKPSNLLIN	MAPK3	161	P27361
PSLERLHLQNNLISK	PODNL1	216	Q6PEZ8
LQKNLFIVNPHLRPA	DNAH6	301	Q9C0G6
TRLAHQLPNLQKLFL	FBXL4	526	Q9UKA2
APAQQLIRHLLLNFL	FANCC	481	Q00597
RDLQLLSQFLKHPQK	ADGRG1	181	Q9Y653
LPALKNFQQHILNIL	LYST	601	Q99698
KPNEHILYNLVLRNL	FHIP2A	481	Q5W0V3
QSLHLQKNQLRALPA	CHADL	646	Q6NUI6
QFTPQHKLLRLQLPN	FERMT2	91	Q96AC1
FLQQFLPLHDSLKLL	CEP295	1046	Q9C0D2
PSHVFSLKQLLQRLL	SERHL2	166	Q9H4I8
ILKNLHSLISPYIQQ	IPO13	606	O94829
LFLQNHVFPLLLSNL	IPO8	456	O15397
QLPLLASLIQHQALF	RTL4	231	Q6ZR62
DVLPQTLQRNLHRLK	SMYD4	181	Q8IYR2
PVQLHQLRAQILAYK	SMARCA2	176	P51531
HNLIQLRDFINKPVL	PLD1	1011	Q13393
QLKQLNLSHGTLRFI	PRAMEF19	321	Q5SWL8
VNLRKHLIDQSFLLP	PKDREJ	731	Q9NTG1
LKLLFLNNNLLRTLP	SLITRK3	506	O94933
ETQYLQHRLQKPSLL	SIK2	676	Q9H0K1
YNNLHLLSQVLPRLK	ST6GALNAC5	186	Q9BVH7
LVLNQPLQSYHQLKL	TGM4	46	P49221
LPILRHQGQQLANKL	ARHGAP5	711	Q13017
LLKKSLEQQFPNHLL	SELENOV	281	P59797
NGLLLKQHLVQNPVR	SPG7	76	Q9UQ90
NLLLALNLHLPAADQ	NCKIPSD	556	Q9NZQ3
KHLLCPSFLNQLRQA	STK36	956	Q9NRP7
LNYLSNLLHSIKNPL	COL24A1	1521	Q17RW2
PLQNLQHVNLKAPRL	TBC1D14	26	Q9P2M4
LSLNRLKHIPNEAFL	TLR8	646	Q9NR97
LILHQNIQILKQPFD	ZNF334	196	Q9HCZ1
LKLQQQQLLLPFYLH	ZFHX2	1356	Q9C0A1
PNLKQRLQVLHLLIL	ARHGAP40	376	Q5TG30
LRILHLANNQLQTFP	PHLPP2	646	Q6ZVD8
QLLHKLNVNLPRQRV	PLCH2	196	O75038
LLPVIQFLQKSIQRH	PWP2	841	Q15269
QAQLTPLLRALKLHT	TONSL	1056	Q96HA7
LQALHQKLAALRQGP	RASGEF1C	156	Q8N431
IQQHFLKPLQRFLKP	VAV1	216	P15498
ANLLPKAVHLANLNL	ZNF592	496	Q92610
QRKHQLLGQVLFPLK	SYT15B	291	X6R8R1
NNILLITNASKFHLP	TMEM131	516	Q92545
HARLKTQLPQQKLQL	TRIM72	126	Q6ZMU5
LSLHQKLVQVRNPLN	ZNF780B	796	Q9Y6R6
VQTILKHLQNLFVPR	RALGAPB	116	Q86X10
NRKLLDFLLQPPHLQ	PPP6R1	41	Q9UPN7
NLLRQLAQKVPHKLN	SNRNP200	1866	O75643
KLALVFNIPLHQINQ	UBP1	481	Q9NZI7
TLLLKHRQTLQLQPS	PHLPP1	176	O60346
AQLRHSLPLQSFLLK	PLEKHG2	221	Q9H7P9
FNRALELNPKHKLAL	TMTC3	621	Q6ZXV5
KLNLHLFKQFTQPRN	TEX2	241	Q8IWB9
PLRKFLQLHSQIFLL	USP40	386	Q9NVE5
YLLRQKSLHLPQKDQ	HIVEP1	1946	P15822
RNISHLDLKPQNILL	ULK3	131	Q6PHR2
LLAHQPLAAKRALQA	TMPPE	366	Q6ZT21
QKLQTNAHNRLELPL	LRRC8C	416	Q8TDW0
HLPLLQFLLLNSNKF	LGI3	86	Q8N145
NQLFLLSPHYLRQVK	MMUT	6	P22033