Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium channel inhibitor activity

NEDD4 NEDD4L

1.90e-058172GO:0019871
GeneOntologyMolecularFunctionsodium channel regulator activity

NEDD4 NEDD4L

6.32e-0444172GO:0017080
GeneOntologyMolecularFunctionion channel inhibitor activity

NEDD4 NEDD4L

7.52e-0448172GO:0008200
GeneOntologyMolecularFunctionchannel inhibitor activity

NEDD4 NEDD4L

8.16e-0450172GO:0016248
GeneOntologyMolecularFunctiontransporter inhibitor activity

NEDD4 NEDD4L

8.49e-0451172GO:0141110
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor internalization

LRP1 NEDD4 NEDD4L

4.17e-0639173GO:0099149
GeneOntologyBiologicalProcesspostsynaptic endocytosis

LRP1 NEDD4 NEDD4L

9.45e-0651173GO:0140239
GeneOntologyBiologicalProcesspostsynaptic neurotransmitter receptor internalization

LRP1 NEDD4 NEDD4L

9.45e-0651173GO:0098884
GeneOntologyBiologicalProcessneurotransmitter receptor internalization

LRP1 NEDD4 NEDD4L

1.40e-0558173GO:0099590
GeneOntologyBiologicalProcessregulation protein catabolic process at postsynapse

NEDD4 NEDD4L

2.87e-0510172GO:0140252
GeneOntologyBiologicalProcessregulation protein catabolic process at synapse

NEDD4 NEDD4L

5.78e-0514172GO:0140250
GeneOntologyBiologicalProcessregulation of receptor internalization

LRP1 NEDD4 NEDD4L

6.14e-0595173GO:0002090
GeneOntologyBiologicalProcessnegative regulation of sodium ion transmembrane transporter activity

NEDD4 NEDD4L

7.62e-0516172GO:2000650
GeneOntologyBiologicalProcessnegative regulation of sodium ion transmembrane transport

NEDD4 NEDD4L

8.63e-0517172GO:1902306
GeneOntologyBiologicalProcessnegative regulation of sodium ion transport

NEDD4 NEDD4L

1.46e-0422172GO:0010766
GeneOntologyBiologicalProcessregulation of receptor-mediated endocytosis

LRP1 NEDD4 NEDD4L

2.67e-04156173GO:0048259
GeneOntologyBiologicalProcessregulation of protein catabolic process

LRP1 SF3B3 NEDD4 NEDD4L

2.90e-04407174GO:0042176
GeneOntologyBiologicalProcessregulation of postsynaptic membrane neurotransmitter receptor levels

LRP1 NEDD4 NEDD4L

3.09e-04164173GO:0099072
GeneOntologyBiologicalProcessreceptor internalization

LRP1 NEDD4 NEDD4L

4.20e-04182173GO:0031623
GeneOntologyBiologicalProcessapoptotic cell clearance

RAB14 LRP1

7.05e-0448172GO:0043277
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process

LRP1 NEDD4 NEDD4L

8.08e-04228173GO:0045732
GeneOntologyBiologicalProcessprotein monoubiquitination

NEDD4 NEDD4L

8.92e-0454172GO:0006513
GeneOntologyBiologicalProcessregulation of sodium ion transmembrane transporter activity

NEDD4 NEDD4L

9.94e-0457172GO:2000649
DomainHECT

NEDD4 NEDD4L

2.70e-0427172PF00632
DomainHECTc

NEDD4 NEDD4L

2.70e-0427172SM00119
DomainHECT_dom

NEDD4 NEDD4L

2.70e-0427172IPR000569
DomainHECT

NEDD4 NEDD4L

2.70e-0427172PS50237
DomainWW

NEDD4 NEDD4L

8.23e-0447172PF00397
DomainWW

NEDD4 NEDD4L

8.58e-0448172SM00456
DomainWW_DOMAIN_2

NEDD4 NEDD4L

9.68e-0451172PS50020
DomainWW_DOMAIN_1

NEDD4 NEDD4L

9.68e-0451172PS01159
DomainWW_dom

NEDD4 NEDD4L

1.01e-0352172IPR001202
DomainC2

NEDD4 NEDD4L

6.20e-03131172PF00168
DomainC2

NEDD4 NEDD4L

6.76e-03137172SM00239
DomainC2

NEDD4 NEDD4L

7.24e-03142172PS50004
Domain-

NEDD4 NEDD4L

7.85e-031481722.60.40.150
DomainC2_dom

NEDD4 NEDD4L

9.56e-03164172IPR000008
DomainSH3_1

NEBL SH3PXD2A

9.56e-03164172PF00018
DomainSH3

NEBL SH3PXD2A

1.62e-02216172PS50002
DomainSH3

NEBL SH3PXD2A

1.62e-02216172SM00326
DomainSH3_domain

NEBL SH3PXD2A

1.67e-02220172IPR001452
Pubmed

Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

NEBL NEDD4 NEDD4L

2.22e-072517323873930
Pubmed

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

NEDD4 NEDD4L

2.25e-07217211502596
Pubmed

Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

NEDD4 NEDD4L

2.25e-07217223262292
Pubmed

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

NEDD4 NEDD4L

2.25e-07217237962894
Pubmed

Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.

NEDD4 NEDD4L

2.25e-07217219602703
Pubmed

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

NEDD4 NEDD4L

2.25e-07217211149908
Pubmed

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.

NEDD4 NEDD4L

2.25e-07217231802037
Pubmed

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

NEDD4 NEDD4L

6.74e-07317211779188
Pubmed

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

NEDD4 NEDD4L

6.74e-07317218498246
Pubmed

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

NEDD4 NEDD4L

6.74e-07317221852580
Pubmed

The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.

NEDD4 NEDD4L

6.74e-07317222361880
Pubmed

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

NEDD4 NEDD4L

6.74e-07317215217910
Pubmed

Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.

NEDD4 NEDD4L

6.74e-07317212729930
Pubmed

Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.

NEDD4 NEDD4L

6.74e-07317219423771
Pubmed

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

NEDD4 NEDD4L

6.74e-07317212050153
Pubmed

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

NEDD4 NEDD4L

6.74e-07317220730100
Pubmed

Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1.

NEDD4 NEDD4L

6.74e-07317226823285
Pubmed

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.

NEDD4 NEDD4L

6.74e-07317223686771
Pubmed

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

NEDD4 NEDD4L

6.74e-07317215677482
Pubmed

The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.

NEDD4 NEDD4L

1.35e-06417227466427
Pubmed

SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.

NEDD4 NEDD4L

1.35e-06417228608480
Pubmed

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.

NEDD4 NEDD4L

1.35e-06417217544362
Pubmed

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

NEDD4 NEDD4L

1.35e-06417220026598
Pubmed

C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.

NEDD4 NEDD4L

1.35e-06417231357244
Pubmed

Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.

NEDD4 NEDD4L

1.35e-06417229897283
Pubmed

NEDD4-2 associates with gamma(c) and regulates its degradation rate.

NEDD4 NEDD4L

1.35e-06417219615332
Pubmed

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

NEDD4 NEDD4L

1.35e-06417222024150
Pubmed

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

NEDD4 NEDD4L

1.35e-06417211696533
Pubmed

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.

NEDD4 NEDD4L

1.35e-06417221463633
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

NEDD4 NEDD4L

2.25e-06517215548568
Pubmed

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

NEDD4 NEDD4L

2.25e-06517225157163
Pubmed

Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

NEDD4 NEDD4L

2.25e-06517230287686
Pubmed

An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.

NEDD4 NEDD4L

2.25e-06517218687683
Pubmed

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.

NEDD4 NEDD4L

2.25e-06517227793840
Pubmed

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

NEDD4 NEDD4L

2.25e-06517222385262
Pubmed

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

NEDD4 NEDD4L

2.25e-06517221478478
Pubmed

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.

NEDD4 NEDD4L

2.25e-06517231867777
Pubmed

A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline.

NEDD4 NEDD4L

2.25e-06517236002265
Pubmed

The ESCRT pathway and HIV-1 budding.

NEDD4 NEDD4L

2.25e-06517219143627
Pubmed

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.

NEDD4 NEDD4L

2.25e-06517219706893
Pubmed

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.

NEDD4 NEDD4L

2.25e-06517219617352
Pubmed

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

NEDD4 NEDD4L

2.25e-06517225631046
Pubmed

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.

NEDD4 NEDD4L

2.25e-06517218577513
Pubmed

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

NEDD4 NEDD4L

2.25e-06517217289006
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

NEDD4 NEDD4L

3.37e-06617215252135
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

NEDD4 NEDD4L

3.37e-06617237156795
Pubmed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

NEDD4 NEDD4L

3.37e-06617227445338
Pubmed

Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.

NEDD4 NEDD4L

3.37e-06617216701206
Pubmed

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

NEDD4 NEDD4L

3.37e-06617226854353
Pubmed

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

NEDD4 NEDD4L

3.37e-06617229964046
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

NEDD4 NEDD4L

3.37e-06617211748237
Pubmed

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

NEDD4 NEDD4L

4.72e-06717230587574
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

NEDD4 NEDD4L

4.72e-06717211046148
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

NEDD4 NEDD4L

4.72e-06717223644597
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

NEDD4 NEDD4L

4.72e-06717220051513
Pubmed

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

NEDD4 NEDD4L

4.72e-06717220086093
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

NEDD4 NEDD4L

4.72e-06717224831002
Pubmed

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

NEDD4 NEDD4L

4.72e-06717216337426
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

NEDD4 NEDD4L

6.29e-06817211244092
Pubmed

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.

NEDD4 NEDD4L

6.29e-06817224036464
Pubmed

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

NEDD4 NEDD4L

6.29e-06817217719543
Pubmed

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.

NEDD4 NEDD4L

8.08e-06917218981174
Pubmed

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

NEDD4 NEDD4L

8.08e-06917215496141
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

NEDD4 NEDD4L

1.01e-051017225092867
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

NEDD4 NEDD4L

1.23e-051117222773947
Pubmed

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.

NEDD4 NEDD4L

1.23e-051117221505443
Pubmed

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

NEDD4 NEDD4L

1.23e-051117225963657
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

NEDD4 NEDD4L

1.75e-051317215123669
Pubmed

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

NEDD4 NEDD4L

1.75e-051317223146885
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

NEDD4 NEDD4L

2.35e-051517223236378
Pubmed

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

NEDD4 NEDD4L

2.69e-051617221920314
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

NEDD4 NEDD4L

3.05e-051717228292929
Pubmed

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

RAB14 SF3B3 NEDD4 NEDD4L

3.37e-0539217433144569
Pubmed

Wrapping up the bad news: HIV assembly and release.

NEDD4 NEDD4L

3.42e-051817223305486
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

NEDD4 NEDD4L

3.83e-051917221572392
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SETDB1 GPATCH8 NEDD4 NEDD4L

3.90e-0540717412693553
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

NEDD4 NEDD4L

4.70e-052117237005481
Pubmed

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

NEDD4 NEDD4L

4.70e-052117229416926
Pubmed

EG-1 interacts with c-Src and activates its signaling pathway.

NEBL NEDD4L

5.16e-052217216964398
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

NEDD4 NEDD4L

7.26e-052617226949039
Pubmed

NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.

NEDD4 NEDD4L

7.84e-052717228931009
Pubmed

Functional proteomics mapping of a human signaling pathway.

LRP1 SETDB1 NEDD4 NEDD4L

1.65e-0459117415231748
Pubmed

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

SETDB1 PSME4

1.91e-04421727584044
Pubmed

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

SH3PXD2A NEDD4L

2.94e-04521729455477
Pubmed

USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.

RAB14 NEDD4L

4.18e-046217231340145
Pubmed

A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.

CRYBB1 GABRR2

4.45e-046417220889312
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

GPATCH8 NEDD4 NEDD4L

4.47e-0431317338270169
Pubmed

TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.

NEDD4 NEDD4L

4.88e-046717235670107
InteractionSCN3A interactions

LRP1 NEDD4 NEDD4L

2.77e-0716173int:SCN3A
InteractionPRRG4 interactions

NEBL NEDD4 NEDD4L

4.47e-0639173int:PRRG4
InteractionPRRG3 interactions

NEDD4 NEDD4L

6.69e-065172int:PRRG3
InteractionCYYR1 interactions

NEDD4 NEDD4L

1.87e-058172int:CYYR1
InteractionMS4A10 interactions

NEDD4 NEDD4L

3.00e-0510172int:MS4A10
InteractionPRRG2 interactions

NEDD4 NEDD4L

3.00e-0510172int:PRRG2
InteractionTMEM252 interactions

NEDD4 NEDD4L

3.67e-0511172int:TMEM252
InteractionILDR1 interactions

NEDD4 NEDD4L

3.67e-0511172int:ILDR1
InteractionSLC38A3 interactions

SETDB1 NEDD4

3.67e-0511172int:SLC38A3
InteractionSCN10A interactions

NEDD4 NEDD4L

3.67e-0511172int:SCN10A
InteractionGRIA1 interactions

LRP1 NEDD4 NEDD4L

4.89e-0586173int:GRIA1
InteractionMYCT1 interactions

MYCT1 NEDD4

5.20e-0513172int:MYCT1
InteractionMOB3A interactions

NEDD4 NEDD4L

6.06e-0514172int:MOB3A
InteractionPRRG1 interactions

NEDD4 NEDD4L

6.99e-0515172int:PRRG1
InteractionPRR16 interactions

NEDD4 NEDD4L

7.98e-0516172int:PRR16
InteractionSUSD6 interactions

NEDD4 NEDD4L

7.98e-0516172int:SUSD6
InteractionNDFIP1 interactions

MYCT1 NEDD4 NEDD4L

8.86e-05105173int:NDFIP1
InteractionTMEM255A interactions

NEDD4 NEDD4L

9.04e-0517172int:TMEM255A
InteractionTMEM92 interactions

NEDD4 NEDD4L

9.04e-0517172int:TMEM92
InteractionTMEM174 interactions

NEDD4 NEDD4L

1.02e-0418172int:TMEM174
InteractionRASL11B interactions

NEDD4 NEDD4L

1.14e-0419172int:RASL11B
InteractionSCN2A interactions

NEDD4 NEDD4L

1.14e-0419172int:SCN2A
InteractionCLIC2 interactions

NEDD4 NEDD4L

1.26e-0420172int:CLIC2
InteractionSCN8A interactions

NEDD4 NEDD4L

1.26e-0420172int:SCN8A
InteractionSKIL interactions

LRP1 SETDB1 NEDD4

1.29e-04119173int:SKIL
InteractionKCNQ1 interactions

NEDD4 NEDD4L

1.39e-0421172int:KCNQ1
InteractionSCGB1D2 interactions

MYCT1 NEDD4L

1.39e-0421172int:SCGB1D2
InteractionSCN9A interactions

NEDD4 NEDD4L

1.39e-0421172int:SCN9A
InteractionSLC22A8 interactions

NEDD4 NEDD4L

1.53e-0422172int:SLC22A8
InteractionSCNN1G interactions

NEDD4 NEDD4L

1.53e-0422172int:SCNN1G
InteractionEXOC5 interactions

RAB14 CRYBB1 SETDB1

1.56e-04127173int:EXOC5
InteractionGBA1 interactions

RAB14 SETDB1 NEDD4

1.79e-04133173int:GBA1
InteractionLUC7L2 interactions

SETDB1 SF3B3 GPATCH8 NEDD4

1.84e-04353174int:LUC7L2
InteractionKCNAB1 interactions

NEDD4 NEDD4L

1.99e-0425172int:KCNAB1
InteractionSLC22A6 interactions

NEDD4 NEDD4L

2.50e-0428172int:SLC22A6
InteractionTHAP8 interactions

RAB14 SETDB1

2.50e-0428172int:THAP8
InteractionSCNN1B interactions

NEDD4 NEDD4L

2.50e-0428172int:SCNN1B
InteractionFBXL15 interactions

NEDD4 NEDD4L

2.68e-0429172int:FBXL15
InteractionSCN1A interactions

NEDD4 NEDD4L

2.68e-0429172int:SCN1A
InteractionMBL2 interactions

LRP1 PSME4

4.38e-0437172int:MBL2
InteractionPIP4P2 interactions

NEDD4 NEDD4L

4.38e-0437172int:PIP4P2
InteractionN4BP1 interactions

NEDD4 NEDD4L

4.62e-0438172int:N4BP1
InteractionIL2RG interactions

NEDD4 NEDD4L

4.87e-0439172int:IL2RG
InteractionTRMT44 interactions

LRP1 SF3B3

5.13e-0440172int:TRMT44
InteractionSRMS interactions

NEDD4 NEDD4L

5.13e-0440172int:SRMS
InteractionMT2A interactions

NEBL NEDD4L

5.39e-0441172int:MT2A
InteractionAPBB1 interactions

LRP1 SF3B3 NEDD4L

5.49e-04195173int:APBB1
InteractionWBP1 interactions

NEDD4 NEDD4L

5.65e-0442172int:WBP1
InteractionAURKC interactions

NEDD4 NEDD4L

5.93e-0443172int:AURKC
InteractionSGK2 interactions

NEDD4 NEDD4L

5.93e-0443172int:SGK2
InteractionPRKX interactions

NEDD4 NEDD4L

6.78e-0446172int:PRKX
InteractionSCN5A interactions

NEDD4 NEDD4L

7.08e-0447172int:SCN5A
InteractionLRP3 interactions

NEDD4 NEDD4L

7.08e-0447172int:LRP3
InteractionXIRP2 interactions

NEBL NEDD4L

7.38e-0448172int:XIRP2
InteractionMAPKAPK3 interactions

NEDD4 NEDD4L

8.01e-0450172int:MAPKAPK3
InteractionERG interactions

SETDB1 SF3B3 NEDD4

8.11e-04223173int:ERG
InteractionARRDC3 interactions

GPATCH8 NEDD4 NEDD4L

8.21e-04224173int:ARRDC3
InteractionPMEPA1 interactions

NEDD4 NEDD4L

8.33e-0451172int:PMEPA1
InteractionSIVA1 interactions

NEDD4 NEDD4L

8.66e-0452172int:SIVA1
InteractionTNFRSF19 interactions

NEDD4 NEDD4L

9.00e-0453172int:TNFRSF19
InteractionNPC2 interactions

LRP1 NEDD4L

9.00e-0453172int:NPC2
InteractionTGFB1I1 interactions

NEDD4 NEDD4L

9.00e-0453172int:TGFB1I1
InteractionCAMK1D interactions

NEDD4 NEDD4L

9.34e-0454172int:CAMK1D
InteractionNDFIP2 interactions

NEDD4 NEDD4L

1.00e-0356172int:NDFIP2
InteractionSMAD6 interactions

NEDD4 NEDD4L

1.00e-0356172int:SMAD6
InteractionRAB39B interactions

RAB14 LRP1

1.00e-0356172int:RAB39B
InteractionNUTM1 interactions

NEBL PSME4

1.04e-0357172int:NUTM1
InteractionMAPK8IP1 interactions

LRP1 NEDD4

1.08e-0358172int:MAPK8IP1
InteractionLDLRAD4 interactions

NEDD4 NEDD4L

1.11e-0359172int:LDLRAD4
InteractionTBC1D7 interactions

NEDD4 NEDD4L

1.15e-0360172int:TBC1D7
InteractionKIFC3 interactions

NEBL NEDD4 NEDD4L

1.15e-03252173int:KIFC3
InteractionKCNAB2 interactions

NEDD4 NEDD4L

1.23e-0362172int:KCNAB2
InteractionLGR4 interactions

SF3B3 NEDD4 NEDD4L

1.29e-03262173int:LGR4
InteractionSCNN1A interactions

NEDD4 NEDD4L

1.31e-0364172int:SCNN1A
InteractionAP1G2 interactions

SF3B3 NEDD4

1.39e-0366172int:AP1G2
InteractionLAPTM5 interactions

NEDD4 NEDD4L

1.43e-0367172int:LAPTM5
InteractionMARK2 interactions

SH3PXD2A NEDD4 NEDD4L

1.47e-03274173int:MARK2
InteractionPSME1 interactions

SETDB1 GPATCH8 PSME4

1.47e-03274173int:PSME1
InteractionARRDC1 interactions

NEDD4 NEDD4L

1.48e-0368172int:ARRDC1
InteractionATG14 interactions

SETDB1 PSME4

1.52e-0369172int:ATG14
InteractionMAP3K2 interactions

NEDD4 NEDD4L

1.70e-0373172int:MAP3K2
InteractionAICDA interactions

NEDD4 NEDD4L

1.70e-0373172int:AICDA
InteractionTMEM171 interactions

NEDD4 NEDD4L

1.84e-0376172int:TMEM171
InteractionLITAF interactions

NEDD4 NEDD4L

1.89e-0377172int:LITAF
InteractionSGK1 interactions

NEDD4 NEDD4L

2.04e-0380172int:SGK1
InteractionCUEDC1 interactions

NEDD4 NEDD4L

2.14e-0382172int:CUEDC1
InteractionWBP2 interactions

NEDD4 NEDD4L

2.14e-0382172int:WBP2
InteractionMAP3K3 interactions

NEDD4 NEDD4L

2.24e-0384172int:MAP3K3
InteractionAKT3 interactions

NEDD4 NEDD4L

2.29e-0385172int:AKT3
InteractionENTREP1 interactions

NEDD4 NEDD4L

2.35e-0386172int:ENTREP1
ToppCellCOPD-Epithelial-Goblet|World / Disease state, Lineage and Cell class

NEBL MUC16 NEDD4L

4.53e-05186173d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYCT1 FAM181B NEDD4

4.60e-05187173dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1 FAM181B

4.60e-05187173e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

NEBL MUC16 CFAP65

4.90e-05191173ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell(4)_Endothelial_cells-(41)_EC-arteriolar|World / Cell class and subclass of bone marrow stroma cells in homeostatis

NEBL MYCT1 FAM181B

4.90e-05191173718c83046668a7c33bd8319b45c56f8edb34cfe7
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

NEBL MUC16 CFAP65

4.90e-051911736228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1 FAM181B

4.98e-05192173c0498baa2556e1597c00df2e75efadeb14bd34ef
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1 FAM181B

4.98e-05192173144503af50274eaed5cf6effa892c640eab28663
ToppCellCOPD-Epithelial-Goblet|COPD / Disease state, Lineage and Cell class

NEBL MUC16 NEDD4L

4.98e-0519217393b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1 FAM181B

4.98e-05192173c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1 FAM181B

4.98e-05192173cb906b10cad76e978c5c0b966215368ebef30e51
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYCT1 NEDD4 NEDD4L

5.06e-05193173e1d546165dcc2392f540162206852c4717d7306f
ToppCellEC-Arteriolar_ECs|World / Lineage and Cell class

NEBL MYCT1 FAM181B

5.13e-0519417338f0c52de252101d4bc8633af80002061635e487
ToppCellNS-critical-d_07-13|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NEBL MUC16 NEDD4L

5.45e-05198173a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCellTracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEBL MUC16 NEDD4L

5.54e-05199173ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCellBronchial-10x5prime-Epithelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEBL MUC16 NEDD4L

5.62e-05200173d3ee5f79513e2ac02ad3329b59e6290d457c44d2
ToppCellTracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SH3PXD2A GPATCH8 NEDD4

5.62e-0520017324e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCellBronchus_Control_(B.)-Epithelial-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

NEBL MUC16 NEDD4L

5.62e-05200173f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Man1a_(Man1a)|Hippocampus / BrainAtlas - Mouse McCarroll V32

IL12B GABRR2

4.17e-0480172d42b72ef822f731ff5ff1d04216e91f414c5556e
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Man1a_(Man1a)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

IL12B GABRR2

4.17e-0480172d3ee8fc9b2cb47ee476f4cd8b9fcba14cb9ca759
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB14 NEDD4

7.44e-04107172c41bc8810df67158f0ae9f6015c965a8ebd96965
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB14 NEDD4

7.44e-0410717260b272f5c89bea8a2714f870e18b7ac89a4a4bf6
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B FAM181B

8.30e-04113172ec4b89e727e1b921b9cb17443774955b95814dd4
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM181B CFAP65

8.89e-04117172f3c77b234e461566aac81ede0ef84008c9a9f51e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MUC16 CFAP65

1.13e-03132172694b79dc31b8d7ef3c01962916d25980b76da33e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MUC16 CFAP65

1.13e-0313217236bb06f9e97a8abbea4d06beff9e38641a5f0ff2
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-5|TCGA-Adrenal / Sample_Type by Project: Shred V9

FAM181B CFAP65

1.16e-03134172d4b175257c47916ed90cdb5c555c2b26530ce8d5
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRR2 CFAP65

1.21e-031371724dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRR2 CFAP65

1.21e-03137172c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|367C / Donor, Lineage, Cell class and subclass (all cells)

CRYBB1 MUC16

1.29e-03141172e409da87da5a38ba4d0ccc5e3f8bd89f480f9dab
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CRYBB1 MUC16

1.34e-031441723ba7f8bd6d1c551048403c94693d63e60f7cbbb7
ToppCellSubstantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBB1 IL12B

1.45e-03150172edbc1d29d213bf5908592135700e0d80e123c923
ToppCellSubstantia_nigra-Hematopoietic-MICROGLIA|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBB1 IL12B

1.45e-03150172d44c02402e59a45e40b8fffbe71284032b5e7c92
ToppCellSubstantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBB1 IL12B

1.45e-0315017201c526e1e3007e71e416c317549fddd2919b14e9
ToppCellSubstantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBB1 IL12B

1.45e-03150172b7f5bf9af7ed50aad4da1c71d37b8b9709e6ce85
ToppCellSubstantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBB1 IL12B

1.45e-03150172e020dbcf85c0ba7ad667b8bbeb6bbcfc135c9bb7
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

MUC16 NEDD4L

1.47e-031511728216462e723fec2797387929dde095370947e10a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL NEDD4L

1.49e-03152172655d47efe0608d729801f1f01668e84c1bc0675f
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB14 NEDD4

1.51e-0315317288ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB14 NEDD4

1.51e-03153172553dff9688a1996d8f4ba16e60c683593d781389
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM181B CFAP65

1.51e-0315317220786807bba3bcd70ce744f8b6454e064199ed9f
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRYBB1 GABRR2

1.53e-03154172ec56b7fb88e39041416c384f371c767f3b4e92fa
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL FAM181B

1.53e-031541721e32969bee810adaf2d560f0824a16227df513d8
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high|E18.5-samps / Age Group, Lineage, Cell class and subclass

MUC16 MYCT1

1.53e-03154172212c340a096a3a9669d1aebd61c045cf1402a868
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SH3PXD2A MYCT1

1.57e-031561726c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

MUC16 CFAP65

1.57e-0315617210d191e29b16cae8238e8df6c0ff38882253f34e
ToppCelldroplet-Heart-nan-3m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1

1.59e-03157172d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NEBL MUC16

1.59e-03157172c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B MYCT1

1.61e-03158172f41ee21e5888359d817be1e3a902c132cb68e350
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B MYCT1

1.61e-03158172d689feb7f612aef170da76fcf14abf2dd589082b
ToppCellfacs-Brain_Myeloid-Cerebellum-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B MYCT1

1.61e-03158172829ff3df46f173f2ff1c435e9bce35425e603b42
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NEBL NEDD4L

1.63e-03159172e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NEBL NEDD4L

1.63e-031591728680b054622f573a82b1625fb93c2d5db81d1034
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM181B CFAP65

1.65e-031601726c89a2e4189e4f2b6b09b66c6aae6653785ab2f8
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 SH3PXD2A

1.65e-031601720544bc465af208da448858d6e174ff56f2e08a46
ToppCellCiliated_cells-B-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

MUC16 CFAP65

1.69e-031621725319603f7ba3f48126dcf2ba9ae604be11bf2577
ToppCellnormal-na-Lymphocytic_B-B_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

MUC16 NEDD4L

1.69e-03162172ae292318d339305932457bb0e91430594f7a3dfa
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

NEBL LRP1

1.71e-03163172f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellfacs-Marrow-T_cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.71e-0316317230cd95d4f37bd54c1fde54960cb005db58bdd30c
ToppCellfacs-Marrow-T_cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.71e-03163172ab934cb986495adfc8dbe5a276577f2a8fb6ee03
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL12B MYCT1

1.73e-031641728f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL12B MYCT1

1.73e-03164172a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL12B MYCT1

1.73e-031641721a1795969673232191425dde84ab24ee6a98143f
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

NEBL LRP1

1.73e-03164172519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SH3PXD2A MYCT1

1.73e-03164172d2218d50e0e2d19f919dcb460b3840687c082810
ToppCelldroplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12B NEDD4L

1.73e-0316417278de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12B NEDD4L

1.75e-03165172c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM181B CFAP65

1.77e-03166172f0912ce0df5ede3bc5e7c99ccfe4decc16c6064e
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NEBL CFAP65

1.77e-03166172eb9c81fa7573de7aff6670e7dad313f02129809f
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL FAM181B

1.80e-03167172cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.80e-03167172a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCellfacs-Brain_Myeloid-Hippocampus-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.80e-031671720e746483773bde6582874a33591ab2a578d724eb
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.80e-031671727f3224af9b30082b927a822b91f96e0c88151b4e
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages|bone_marrow / Manually curated celltypes from each tissue

LRP1 CRYBB1

1.82e-031681728ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|390C / Donor, Lineage, Cell class and subclass (all cells)

CRYBB1 GABRR2

1.82e-031681722082b15fc7935a211f1c61506b305af5501a21ad
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MUC16 NEDD4L

1.82e-03168172e870d2e69316406f45112ed0bf324b24f902a99e
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CFAP65

1.82e-0316817295416f352801ce42cc317565e7dfb00478c593e1
ToppCellControl|World / group, cell type (main and fine annotations)

NEBL NEDD4L

1.82e-03168172a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM181B CFAP65

1.82e-03168172100ab6d36592b61f4db9f8cb90c48afac016d679
ToppCell10x5'-GI_small-bowel-Myeloid_Mac-Macrophage|GI_small-bowel / Manually curated celltypes from each tissue

LRP1 IL12B

1.82e-03168172d5b746d6083c2c8155a0ea345ea368bf6617d5ca
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MUC16 NEDD4L

1.82e-03168172403aba73a0f9ffb32252288d075fad8a588ca440
ToppCelldroplet-Heart-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NEDD4

1.84e-031691722e5bb6437bc9c614e337c5ffb6f6457cd9fc7f4c
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NEBL MUC16

1.84e-0316917240b557549fe08c5dc9dba359af35993d68d1640a
ToppCellfacs-Lung-Endomucin-24m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCT1 FAM181B

1.84e-03169172d2862a7ddee6d7a65d84ef9d0800ba6f4690973f
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL FAM181B

1.84e-0316917230141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCT1 FAM181B

1.84e-031691728dba7546adc6b1345933eec81fc77fc9611fae60
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 CFAP65

1.84e-0316917214aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1

1.86e-0317017250c6c571591aa4b218caefe5778c570c809f567e
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

NEBL NEDD4L

1.86e-03170172e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellfacs-Marrow-B-cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NEDD4L

1.86e-031701726e82e41acd1299aa549a32ac036b39754abdf376
ToppCelldroplet-Spleen-nan-21m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.86e-0317017203cb4e508356f85372a588c8d1c6babf2a012683
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.86e-03170172b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCellCOVID-19_Convalescent-Hematopoietic_SC|COVID-19_Convalescent / Disease group, lineage and cell class

CRYBB1 MYCT1

1.86e-031701728a73d5334eed1cd9fdcc3ebeae0bdf9f945c228a
ToppCellfacs-Marrow-B-cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NEDD4L

1.86e-0317017218cd941bf3ca7cc0b6af1317bd2619d283353de0
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1

1.86e-031701728fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NEBL NEDD4L

1.86e-03170172a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL MYCT1

1.86e-031701723232db50b1a40f861e981a1b9c9073b81af9f832
ToppCelldroplet-Spleen-nan-21m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 CRYBB1

1.88e-031711729498c35b2a2c3a339dc8c5d49c8ec20d8ad52753
ToppCellPBMC-Convalescent-Hematopoietic-HSPC|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CRYBB1 MYCT1

1.88e-03171172172db31a37b72fb87fe5f0f79da51866b90dd1ad
ToppCellPBMC-Convalescent-Hematopoietic-HSPC-HSPC|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CRYBB1 MYCT1

1.88e-031711722031797d579ce373921affad70da6e50eec13664
DrugLiothyronine [6893-02-3]; Down 200; 6.2uM; PC3; HT_HG-U133A

NEBL LRP1 GABRR2 SETDB1

1.16e-051961746602_DN
DrugKhellin [82-02-0]; Down 200; 15.4uM; PC3; HT_HG-U133A

NEBL LRP1 IL12B SETDB1

1.21e-051981746641_DN
DrugDiethylcarbamazine citrate [1642-54-2]; Up 200; 10.2uM; PC3; HT_HG-U133A

NEBL IL12B GABRR2 MYCT1

1.23e-051991745066_UP
Diseaseunipolar depression, age at onset

GABRR2 SH3PXD2A NEDD4L

1.55e-0640173EFO_0003761, EFO_0004847
DiseaseLiddle syndrome (implicated_via_orthology)

NEDD4 NEDD4L

1.87e-064172DOID:0050477 (implicated_via_orthology)
DiseaseSchizophrenia

LRP1 IL12B SH3PXD2A SETDB1 CFAP65

1.09e-04883175C0036341
Diseaseautistic disorder (is_implicated_in)

GABRR2 SETDB1

2.65e-0442172DOID:12849 (is_implicated_in)
DiseaseMalignant mesothelioma

IL12B SETDB1

1.77e-03109172C0345967
DiseaseParoxysmal atrial fibrillation

NEBL SH3PXD2A

3.59e-03156172C0235480
DiseasePersistent atrial fibrillation

NEBL SH3PXD2A

3.59e-03156172C2585653
Diseasefamilial atrial fibrillation

NEBL SH3PXD2A

3.59e-03156172C3468561
DiseaseAtrial Fibrillation

NEBL SH3PXD2A

3.77e-03160172C0004238
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

SF3B3 NEDD4L

8.20e-03239172EFO_0010934
Diseaseasthma, response to diisocyanate

SH3PXD2A NEDD4L

9.71e-03261172EFO_0006995, MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
YPRWNTWSSSYRSDR

CRYBB1

121

P53674
YDITRRSTYNHLSSW

RAB14

91

P61106
HRSWISTTSSYNRRY

MUC16

12026

Q8WXI7
STTSSYNRRYWTPAT

MUC16

12031

Q8WXI7
GRSYYVDHNSRTTTW

NEDD4

781

P46934
TLYWTSYTTSTITRH

LRP1

2296

Q07954
RSQYSWTITYSLLSH

CFAP65

1071

Q6ZU64
STTAHSWQRSRSYSR

GPATCH8

976

Q9UKJ3
SAGYSRTAYSSLWRS

FAM181B

396

A6NEQ2
ISVRAQDRYYSSSWS

IL12B

306

P29460
TSRLAFYSSTGWYNR

GABRR2

236

P28476
WSSSRRSRSSYTHGL

MYCT1

106

Q8N699
FSTSSVWRSYATRRQ

SETDB1

916

Q15047
TWSDSTSQTIYRRYS

SH3PXD2A

31

Q5TCZ1
RSSSWHARYTVLTYL

PSME4

1651

Q14997
SSRSWLSYSYQSRFH

SF3B3

716

Q15393
YRRHWSRSHSSSTFG

NEBL

876

O76041
TYYVNHNNRTTTWTR

NEDD4L

401

Q96PU5