Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	3.05e-25	431	98	29	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	9.89e-21	884	98	33	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 CHRNA5 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 MST1R OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1 MUSK	6.94e-18	1353	98	36	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8H2 OR8U1 OR6N2 OR8U3 OR8U9 OR8U8	3.84e-05	127	98	6	GO:0005549
GeneOntologyMolecularFunction	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	B4GAT1 B3GNT2	3.53e-04	6	98	2	GO:0008532
GeneOntologyMolecularFunction	LIM domain binding	LDB2 LDB1	8.39e-04	9	98	2	GO:0030274
GeneOntologyBiologicalProcess	sensory perception of smell	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 ADCY3 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1 B3GNT2	1.24e-27	465	96	31	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	6.82e-26	432	96	29	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 ADCY3 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1 B3GNT2	1.72e-25	547	96	31	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 CHRNA5 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 PIEZO2 OR4C15 OR10H2 OR10H1	1.11e-24	582	96	31	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	1.84e-24	485	96	29	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	1.63e-23	524	96	29	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 PIEZO1 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 CHRNA5 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 PIEZO2 OR4C15 OR10H2 OR10H1	4.72e-23	722	96	32	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 ADCY3 OR6X1 CHRNA5 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 PIEZO2 OR4C15 OR10H2 OR10H1 B3GNT2	6.24e-20	1072	96	34	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 TSHB OR8U3 OR2T10 PTGIR ADCY3 OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	2.51e-17	1395	96	35	GO:0007186
Domain	Olfact_rcpt	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	7.88e-25	393	94	28	IPR000725
Domain	7tm_1	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	6.09e-23	677	94	32	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	8.71e-23	685	94	32	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	1.14e-22	691	94	32	PS50262
Domain	GPCR_Rhodpsn	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	1.19e-22	692	94	32	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 AVPR1B OR2G6 OR4D10 OR4D9 OR8S1 OR10H4 OR4D6 OR2T5 OR4D11 OR8U3 OR2T10 PTGIR OR6X1 OR6N1 OR8U9 OR8U8 OPRL1 OR51E2 OR51S1 OR52I1 OR6V1 KISS1R OR4C15 OR10H2 OR10H1	8.65e-21	670	94	30	IPR017452
Domain	PIEZO	PIEZO1 PIEZO2	2.51e-05	2	94	2	PF15917
Domain	Piezo_RRas-bd_dom	PIEZO1 PIEZO2	2.51e-05	2	94	2	IPR031334
Domain	LIM-bd/SEUSS	LDB2 LDB1	2.51e-05	2	94	2	IPR029005
Domain	Piezo	PIEZO1 PIEZO2	2.51e-05	2	94	2	IPR027272
Domain	Piezo_RRas_bdg	PIEZO1 PIEZO2	2.51e-05	2	94	2	PF12166
Domain	Piezo_dom	PIEZO1 PIEZO2	2.51e-05	2	94	2	IPR031805
Domain	ARM-type_fold	COPB1 NOC2L MAP3K1 RYR3 PPP2R1A UPF2 MMS19 WDFY3	3.11e-04	339	94	8	IPR016024
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 ADCY3 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 LDB1 OR10H2 OR10H1	4.55e-26	417	85	31	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR4Q2 OR2G6 OR4D10 OR4D9 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 ADCY3 OR6X1 OR6N1 OR8U9 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 LDB1 OR10H2 OR10H1	1.41e-20	636	85	31	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H2 OR2T29 OR10H5 OR8U1 OR6N2 OR2G6 OR4D10 OR4D9 OR8S1 OR10H4 OR4D6 OR2T5 OR4D11 OR8U3 OR2T10 ADCY3 OR6X1 OR6N1 OR8U8 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	1.44e-20	389	85	26	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T29 OR10H5 OR2J1 OR2T5 OR51E2 OR10H2 OR10H1	1.99e-07	70	85	7	MM14984
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T29 OR10H5 OR2J1 OR2T5 OR51E2 OR10H2 OR10H1	1.47e-04	190	85	7	MM15687
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8H2 OR2T29 OR8U1 OR6N2 OR4D10 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR6X1 OR6N1 OR51E2 OR51S1 OR52I1 OR4C15 OR10H1	9.58e-21	340	100	20	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8H2 OR2T29 OR8U1 OR6N2 OR4D10 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR6X1 OR6N1 OR51E2 OR51S1 OR52I1 OR4C15 OR10H1	9.58e-21	340	100	20	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8H2 OR2T29 OR8U1 OR6N2 OR4D10 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR6X1 OR6N1 OR51E2 OR51S1 OR52I1 OR4C15 OR10H1	1.14e-20	343	100	20	32295537
Pubmed	The human olfactory receptor gene family.	OR8H2 OR10H5 OR6N2 OR4Q2 OR4D10 OR4D9 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR2T10 OR6X1 OR6N1 OR51E2 OR51S1 OR52I1 OR6V1 OR4C15 OR10H2 OR10H1	1.33e-20	541	100	23	14983052
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8H2 OR2T29 OR8U1 OR6N2 OR4D10 OR8S1 OR1F12P OR10H4 OR4D6 OR2J1 OR2T5 OR4D11 OR8U3 OR6X1 OR6N1 OR51E2 OR51S1 OR52I1 OR4C15 OR10H1	1.35e-20	346	100	20	14611657
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR10H5 OR4Q2 OR4D10 OR10H4 OR4D6 OR4D11 OR6N1 OR10H2 OR10H1	1.53e-08	219	100	9	12213199
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR8U3 ADCY3 OR51E2 OR51S1 OR52I1	3.95e-08	33	100	5	17350283
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO1 PIEZO2	8.18e-06	2	100	2	21299953
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO1 PIEZO2	8.18e-06	2	100	2	38395992
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO1 PIEZO2	8.18e-06	2	100	2	37820892
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO1 PIEZO2	8.18e-06	2	100	2	39251883
Pubmed	Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.	ADCY3 OPRL1	8.18e-06	2	100	2	34914639
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO1 PIEZO2	8.18e-06	2	100	2	37975162
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO1 PIEZO2	8.18e-06	2	100	2	28636944
Pubmed	Piezo channels: from structure to function.	PIEZO1 PIEZO2	8.18e-06	2	100	2	25037583
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO1 PIEZO2	8.18e-06	2	100	2	30324494
Pubmed	Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.	LDB2 LDB1	8.18e-06	2	100	2	16815859
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO1 PIEZO2	8.18e-06	2	100	2	21056836
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO1 PIEZO2	8.18e-06	2	100	2	30745454
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO1 PIEZO2	8.18e-06	2	100	2	36717101
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO1 PIEZO2	8.18e-06	2	100	2	26236150
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO1 PIEZO2	8.18e-06	2	100	2	27743844
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO1 PIEZO2	8.18e-06	2	100	2	38928429
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO1 PIEZO2	8.18e-06	2	100	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO1 PIEZO2	8.18e-06	2	100	2	26008989
Pubmed	Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2.	LDB2 LDB1	8.18e-06	2	100	2	10083735
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO1 PIEZO2	8.18e-06	2	100	2	20813920
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO1 PIEZO2	8.18e-06	2	100	2	32142647
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO1 PIEZO2	8.18e-06	2	100	2	34464353
Pubmed	Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.	LDB2 LDB1	8.18e-06	2	100	2	9799849
Pubmed	Cofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.	LDB2 LDB1	2.45e-05	3	100	2	27129775
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM73 TRIM74	2.45e-05	3	100	2	26196062
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO1 PIEZO2	2.45e-05	3	100	2	30726728
Pubmed	Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.	PIEZO1 PIEZO2	2.45e-05	3	100	2	38124148
Pubmed	Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.	LDB2 LDB1	2.45e-05	3	100	2	8918878
Pubmed	Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study.	XRCC2 LIG4	2.45e-05	3	100	2	14578164
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO1 PIEZO2	2.45e-05	3	100	2	29521261
Pubmed	PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.	PIEZO1 PIEZO2	2.45e-05	3	100	2	30361375
Pubmed	Piezo1, a mechanically activated ion channel, is required for vascular development in mice.	PIEZO1 PIEZO2	2.45e-05	3	100	2	24958852
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO1 PIEZO2	2.45e-05	3	100	2	37321223
Pubmed	Polymorphisms in DNA double-strand break repair genes and skin cancer risk.	XRCC2 LIG4	2.45e-05	3	100	2	15126335
Pubmed	The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.	LDB2 LDB1	2.45e-05	3	100	2	19675209
Pubmed	Spire1 and Myosin Vc promote Ca2+-evoked externalization of von Willebrand factor in endothelial cells.	SPIRE1 MYO5C	2.45e-05	3	100	2	35084586
Pubmed	Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.	PIEZO1 PIEZO2	2.45e-05	3	100	2	35650194
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM73 TRIM74	2.45e-05	3	100	2	22872646
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	PIEZO1 PIEZO2	4.89e-05	4	100	2	27893727
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	PIEZO1 PIEZO2	4.89e-05	4	100	2	36574677
Pubmed	B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan.	B4GAT1 B3GNT2	4.89e-05	4	100	2	25279697
Pubmed	Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.	PIEZO1 PIEZO2	4.89e-05	4	100	2	36563677
Pubmed	DNA ligase IV as a new molecular target for temozolomide.	XRCC2 LIG4	4.89e-05	4	100	2	19615340
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	PIEZO1 PIEZO2	8.14e-05	5	100	2	34852225
Pubmed	Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.	TRIM73 TRIM74	8.14e-05	5	100	2	18398435
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	TRIM73 TRIM74	8.14e-05	5	100	2	20049703
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO1 PIEZO2	8.14e-05	5	100	2	36323321
Pubmed	Isl1 and Ldb co-regulators of transcription are essential early determinants of mouse limb development.	LDB2 LDB1	8.14e-05	5	100	2	22411555
Pubmed	Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators.	LDB2 LDB1	8.14e-05	5	100	2	9860983
Pubmed	Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.	MYO1E MYO5C NEDD4	9.78e-05	31	100	3	30642949
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	COPB1 PPP2R1A RNF123 MMS19	1.19e-04	87	100	4	17148452
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR3 MUSK	1.22e-04	6	100	2	26025922
Pubmed	A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.	LDB2 LDB1	1.22e-04	6	100	2	9192866
Pubmed	Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency.	XRCC2 LIG4	1.22e-04	6	100	2	19164512
Pubmed	Variants in DNA double-strand break repair genes and breast cancer susceptibility.	XRCC2 LIG4	1.22e-04	6	100	2	12023982
Pubmed	Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons.	B4GAT1 B3GNT2	1.22e-04	6	100	2	15728829
Pubmed	TRIM50 regulates Beclin 1 proautophagic activity.	TRIM73 TRIM74	1.22e-04	6	100	2	29604308
Pubmed	TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.	TRIM73 TRIM74	1.22e-04	6	100	2	36178239
Pubmed	Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.	XRCC2 LIG4	1.70e-04	7	100	2	16485136
Pubmed	Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.	PIEZO1 PIEZO2	1.70e-04	7	100	2	38733989
Pubmed	Abnormal development of the neuromuscular junction in Nedd4-deficient mice.	NEDD4 MUSK	1.70e-04	7	100	2	19345204
Pubmed	Novel human G-protein-coupled receptors.	OR52I1 OR6V1	1.70e-04	7	100	2	12732197
Pubmed	Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.	TRIM73 TRIM74	1.70e-04	7	100	2	26025256
Pubmed	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.	XRCC2 LIG4	1.70e-04	7	100	2	21974800
Pubmed	Piezo1 and Piezo2 collectively regulate jawbone development.	PIEZO1 PIEZO2	2.27e-04	8	100	2	38619396
Pubmed	Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development.	XRCC2 LIG4	2.27e-04	8	100	2	16777961
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	PIEZO1 PIEZO2	2.27e-04	8	100	2	34112781
Pubmed	The diploid genome sequence of an individual human.	OR8U1 OR8U9	2.27e-04	8	100	2	17803354
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	PIEZO1 PIEZO2	2.27e-04	8	100	2	38228630
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	PIEZO1 PIEZO2	2.27e-04	8	100	2	27161260
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR3 MUSK	2.27e-04	8	100	2	21441923
Pubmed	Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.	XRCC2 LIG4	2.27e-04	8	100	2	15958648
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	NOC2L PPP2R1A NOP58 MED23	2.37e-04	104	100	4	26167872
Pubmed	URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.	POLR1A PPP2R1A NOP58	2.44e-04	42	100	3	27780869
Pubmed	Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.	XRCC2 LIG4	2.91e-04	9	100	2	19127255
Pubmed	Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions.	XRCC2 LIG4	2.91e-04	9	100	2	18579371
Pubmed	Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.	PPP2R1A SIK2	2.91e-04	9	100	2	24841198
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	OR2T29 OR10H5 OR2T5 OR10H2 OR10H1	3.24e-04	205	100	5	12040188
Pubmed	Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.	XRCC2 LIG4	3.63e-04	10	100	2	18990028
Pubmed	Expression of olfactory receptors in the cribriform mesenchyme during prenatal development.	ADCY3 OR51E2	3.63e-04	10	100	2	15261832
Pubmed	Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.	LDB2 LDB1	4.43e-04	11	100	2	11882901
Pubmed	Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells.	LDB2 LDB1	5.30e-04	12	100	2	17991461
Pubmed	RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.	LDB2 LDB1	5.30e-04	12	100	2	10431247
Pubmed	Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex.	LDB2 LDB1	5.30e-04	12	100	2	12619132
Pubmed	Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.	XRCC2 LIG4	7.28e-04	14	100	2	17018785
Pubmed	Cell-fate determination by ubiquitin-dependent regulation of translation.	POLR1A NOP58	7.28e-04	14	100	2	26399832
Pubmed	β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.	ADCY3 B3GNT2	7.28e-04	14	100	2	21525298
Pubmed	Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.	XRCC2 LIG4	7.28e-04	14	100	2	24899707
Pubmed	Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.	MYO1E MYO5C	7.28e-04	14	100	2	8022818
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	AVPR1B NOC2L OR2G6 AADACL3 LINC00862 ID3 OR2T5 DNAJC6 OR6N1 CHD5	7.81e-04	1031	100	10	16710414
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	POLR1A PARP14 LIG4 HELZ ABCC10	7.97e-04	250	100	5	33536335
Pubmed	A vagal reflex evoked by airway closure.	PIEZO1 PIEZO2	9.57e-04	16	100	2	38448588
Pubmed	LDB1 Is Required for the Early Development of the Dorsal Telencephalon and the Thalamus.	LDB2 LDB1	9.57e-04	16	100	2	30873428
Interaction	ABCC10 interactions	SLC17A2 AVPR1B OPRL1 OR10H2 OR10H1 ABCC10	7.71e-09	36	84	6	int:ABCC10
Interaction	SNX14 interactions	SLC17A2 AVPR1B PTGIR OR10H2 OR10H1	5.99e-06	62	84	5	int:SNX14
Cytoband	11q12.1	OR8H2 OR8U1 OR4D10 OR4D9 OR4D6 OR4D11 OR8U3	6.97e-08	161	100	7	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR8H2 OR8U1 OR4D10 OR4D9 OR4D6 OR4D11 OR8U3	1.12e-05	345	100	7	chr11q12
Cytoband	10q24-q25	LDB1 MMS19	2.81e-05	4	100	2	10q24-q25
Cytoband	1q44	OR2T29 OR2G6 OR2T5 OR2T10	1.02e-04	110	100	4	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T29 OR2G6 OR2T5 OR2T10	1.84e-04	128	100	4	chr1q44
Cytoband	1q23.1	OR6N2 OR6N1	4.57e-03	46	100	2	1q23.1
Cytoband	11q11	OR8U8 OR4C15	4.76e-03	47	100	2	11q11
Cytoband	19p13.1	OR10H2 OR10H1	4.96e-03	48	100	2	19p13.1
GeneFamily	Olfactory receptors, family 8	OR8H2 OR8U1 OR8S1 OR8U9 OR8U8	2.02e-06	49	77	5	155
GeneFamily	Olfactory receptors, family 4	OR4Q2 OR4D10 OR4D9 OR4D6 OR4D11 OR4C15	1.84e-05	129	77	6	151
GeneFamily	Olfactory receptors, family 6	OR6N2 OR6X1 OR6N1 OR6V1	6.53e-05	51	77	4	153
GeneFamily	Olfactory receptors, family 2	OR2T29 OR2G6 OR2J1 OR2T5 OR2T10	1.20e-04	113	77	5	149
GeneFamily	Olfactory receptors, family 10	OR10H5 OR10H4 OR10H2 OR10H1	1.79e-04	66	77	4	157
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD4 BCAN SRPX2	1.84e-03	57	77	3	1179
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CNKSR2 STEAP2 PTGIR SRPX2 PIEZO2 MUSK	5.36e-06	200	98	6	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CNKSR2 STEAP2 PTGIR SRPX2 PIEZO2 MUSK	5.36e-06	200	98	6	a510deaada669e690329183e18df02870bd204b3
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CNKSR2 STEAP2 PTGIR SRPX2 PIEZO2 MUSK	5.36e-06	200	98	6	dd4228cbed8a4395166a6332e08d44d88bebe3b9
Disease	MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 13	B4GAT1 B3GNT2	8.79e-06	2	88	2	C3809042
Disease	C-reactive protein measurement	OR8U1 FOLH1 LINC00862 ANXA6 OR8U3 DNAJC6 ADCY3 MAP3K1 OPRL1 MST1R NOP58 MUSK	2.40e-04	1206	88	12	EFO_0004458
Disease	glycosaminoglycan xylosylkinase measurement	B3GNT2 MUSK	3.90e-04	10	88	2	EFO_0801647
Disease	fatty acid measurement, fetal genotype effect measurement, breast milk measurement	SNX29 MUSK	6.71e-04	13	88	2	EFO_0005110, EFO_0007959, EFO_0009092
Disease	fatty acid measurement, breast milk measurement, parental genotype effect measurement	SNX29 MUSK	7.82e-04	14	88	2	EFO_0005110, EFO_0005939, EFO_0009092
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	MYO1E MUSK	7.82e-04	14	88	2	OBA_2045142
Disease	nasopharynx carcinoma (is_implicated_in)	CHRNA5 MST1R	9.00e-04	15	88	2	DOID:9261 (is_implicated_in)
Disease	third ventricle volume measurement	LDB2 LDB1	9.00e-04	15	88	2	EFO_0010335
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	TFAP2D SNX29 LDB2 MST1R LDB1 EIF4E3	1.24e-03	398	88	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	MYO1E MUSK	1.45e-03	19	88	2	OBA_2045140
Disease	non-small cell lung carcinoma	CHRNA5 PIEZO2 MUSK	1.48e-03	75	88	3	EFO_0003060
Disease	total iron binding capacity	SLC17A2 B3GNT2 MUSK	1.66e-03	78	88	3	EFO_0006334
Disease	proprotein convertase subtilisin/kexin type 9 measurement	CNKSR2 MUSK	1.95e-03	22	88	2	EFO_0009312
Disease	cigarettes per day measurement	ADCY3 SNX29 CHRNA5 EIF4E3 MED23 MIA	2.01e-03	438	88	6	EFO_0006525
Disease	level of Phosphatidylethanolamine (16:0_18:2) in blood serum	MYO1E MUSK	2.33e-03	24	88	2	OBA_2045136
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	OR6N2 RYR3	2.33e-03	24	88	2	EFO_0006821, EFO_0006826
Disease	depressive symptom measurement, response to antidepressant	PIEZO1 MUC5B ADCY3	2.34e-03	88	88	3	EFO_0007006, GO_0036276
Disease	smoking cessation	CHRNA5 MST1R EIF4E3 NAA16 MIA	2.92e-03	325	88	5	EFO_0004319

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDPNYLHRMTTLFCI	PPP2R1A	491	P30153
AYVSLFMRHLCEPGA	CHD5	1466	Q8TDI0
TVLAYALSSHCPDMR	B4GAT1	136	O43505
ARVAMHLVCPSRYEA	B4GAT1	151	O43505
RMDDSYCLSALRSPF	GSE1	266	Q14687
SFLHFPCSMRILSAL	AADACL3	386	Q5VUY0
RFMTILCTRSYPHLR	ANXA6	546	P08133
CLDAYRRHDLSLMSH	TFAP2D	136	Q7Z6R9
RCPRALSIHYKSMDI	MUC5B	5131	Q9HC84
HFYCDDMPLLRLTCS	OR8U8	176	P0C7N1
CRMYGAHLASISTPE	BCAN	716	Q96GW7
CESRLHTPMYFLLRN	OR4D11	51	Q8NGI4
HRCILGMLSYTTRLL	ABCC10	766	Q5T3U5
AAMCLGLAHSLSRYR	NOP58	136	Q9Y2X3
SSMAHDRYAAICSPL	OR8H2	116	Q8N162
FLVVCLDSRLHTPMY	OR6N1	46	Q8NGY5
KTSPYCLTRAELMEH	LINC01548	31	A6NM66
SERSLHMPMYLFLCA	OR10H5	51	Q8NGA6
SERSLHTPMYLFLCV	OR10H2	51	O60403
ICHPLHYSTIMALRL	OR1F12P	126	Q8NHA8
LHYTVLMHPRFCRLL	OR2J1	131	Q9GZK6
CKPLHYSSIMNRRLC	OR4C15	126	Q8NGM1
MSRHKTYSLSPRDCL	LDB1	256	Q86U70
EYIKLMHRTSACLPS	NEDD4	411	P46934
LRYHPLSSCLTARLM	MMS19	811	Q96T76
RHYCTMFHTLDKSPL	FNDC9	86	Q8TBE3
MLCLGLTARAHATDY	CFAP65	1611	Q6ZU64
TLRVDCTPLMYSLVH	FOLH1	461	Q04609
LMSRHKTYNLSPRDC	LDB2	216	O43679
YPVLMNHRVCLFLAS	OR2T5	136	Q6IEZ7
AMAFDRYVAICHPLR	OR51E2	116	Q9H255
MSIDRALAICRPLHY	OR51S1	126	Q8NGJ8
AICRPLHYTTVMSRG	OR4Q2	126	P0C623
EEYRMACHNLLPFTS	NAA16	821	Q6N069
LMPAIRACLEHRHSY	COPB1	136	P53618
HSPKRISFLYDCLAM	MED23	71	Q9ULK4
PLLATCACYAAMLRH	KISS1R	216	Q969F8
CESRLHTPMYFLLRN	OR4D6	51	Q8NGJ1
MSFDRYLTICNPLHH	OR6X1	116	Q8NH79
NRLPLCEMHYALDRI	HELZ	596	P42694
FYPLRMHCIRALTLL	NOC2L	451	Q9Y3T9
HFYCDDMPLLRLTCS	OR8U9	176	P0C7N5
TSLPLRCSYHLMRGE	EIF4E3	96	Q8N5X7
LRYNVLMSPRDCAHL	OR10H4	131	Q8NGA5
ICHPLRYSVLMSHRV	OR2T10	126	Q8NGZ9
YPVLMNHRVCLFLAS	OR2T29	136	Q8NH02
CESHLHTPMYFLLRN	OR4D9	51	Q8NGE8
MALDRFVAICHPLRY	OR6V1	116	Q8N148
MRSCPRYHELLREAT	ACP4	156	Q9BZG2
MIISPGRYFLLCHSS	PARP14	471	Q460N5
FSVIRLDAALHTPMY	OR6N2	46	Q8NGY6
ARLSYLLMCLESAVH	GLG1	396	Q92896
PKLLCMRSHVDRYFT	CHRNA5	361	P30532
DCSPLSMFRRHTVYL	LIG4	806	P49917
RECSMPSAYTQHLRE	C19orf71	101	A6NCJ1
PSHRRYLGYMCDLLA	DNAJC6	206	O75061
LPDYREDHAVCSILM	ADCY3	376	O60266
EPLSLLDDMNHCYSR	ID3	36	Q02535
NCMASHLTPAVYARL	CKMT1A	61	P12532
SERSLHTPMYLFLCA	OR10H1	51	Q9Y4A9
FYARLVATLHPCMSD	UPF2	621	Q9HAU5
LQDYMAPDCRFLTIH	MIA	51	Q16674
ILVCCLDSRLHTPMY	OR2G6	46	Q5TZ20
RYIAIMHPRFCASLA	OR2G6	131	Q5TZ20
LTAMSVDRYVAICHP	OPRL1	141	P41146
TMAFDRYVAICKPLH	OR52I1	121	Q8NGK6
CESRLHTPMYFLLHN	OR4D10	51	Q8NGI6
KTLRAMLVYTPCHSL	MAP3K1	656	Q13233
MLVYTPCHSLAERIK	MAP3K1	661	Q13233
HFYCDDMPLLRLTCS	OR8U1	176	Q8NH10
VDPRHLSLVADYMCF	POLR1A	1636	O95602
YLHMLLADRCRLSTF	SNX29	131	Q8TEQ0
RLMAATSCRSLHLYN	RGP1	201	Q92546
LFCRMSVDLALLFPH	LINC00862	76	A6NCI5
IPYFMSEDCEHLIRR	SIK2	236	Q9H0K1
HVAYSLCLPMRRSER	STEAP2	316	Q8NFT2
SGMAYDRHAAICRPL	OR8S1	116	Q8NH09
ICSPLHYSTLMSRRV	OR8U3	126	Q8NH85
TCIHPESYDIAMRFL	SRBD1	826	Q8N5C6
ICSYVDLMLVHSRKP	B3GNT2	366	Q9NY97
MSCASPYVEAKHSRL	CNKSR2	716	Q8WXI2
VSLSYHLDTKVRCPM	TRIM74	41	Q86UV6
LAMTLDRYLAVCHPL	AVPR1B	126	P47901
HTVFCTLTAAMRYEP	WDFY3	686	Q8IZQ1
LTLACKMRQLEPSHY	TIAM2	836	Q8IVF5
YCRQMRCHALPFITS	SRPX2	116	O60687
IVRACSELRHMPYVD	TMEM181	476	Q9P2C4
FAMAVERCLALSHPY	PTGIR	111	P43119
IYCRLSMPVECHSSF	RYR3	1286	Q15413
PEYMVCFLHRLISAL	RNF123	551	Q5XPI4
YRDVMKLCAAHLPTE	SPIRE1	196	Q08AE8
FKIRYPDLHNMVSLC	SUSD4	151	Q5VX71
PDFCSLRYGLALIMH	SLC17A2	11	O00624
VPDFIHCRSYLDMSK	PIEZO2	1276	Q9H5I5
YSTHELCERFARIML	USP25	1031	Q9UHP3
FCIPTEYTMHIERRE	TSHB	21	P01222
EMLYHLTARCILPKS	XRCC2	56	O43543
VSLSYHLDTKVRCPM	TRIM73	41	Q86UV7
LEHTRYPCLDLGAML	PIEZO1	506	Q92508
PNFIHCRSYLDMLKV	PIEZO1	1146	Q92508
LPYMCHGDLLQFIRS	MST1R	1161	Q04912
ERLPSCFDYVMHFLT	SLC8A2	716	Q9UPR5
DLVSTLMKCTPHYIR	MYO1E	571	Q12965
PAHILFMCVRYADSL	MYO5C	1396	Q9NQX4
LYRSEMHLLSVPECS	MUSK	421	O15146