Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP2 VLDLR LRP12 LRP1B

9.75e-0916324GO:0005041
GeneOntologyMolecularFunctioncalcium ion binding

DNER LRP2 VLDLR THBS1 THBS2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

1.21e-087493211GO:0005509
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP2 VLDLR LRP12 LRP1B

3.19e-0821324GO:0030228
GeneOntologyMolecularFunctionrecombination hotspot binding

PRDM9 PRDM7

2.49e-062322GO:0010844
GeneOntologyMolecularFunctioncargo receptor activity

LRP2 VLDLR LRP12 LRP1B

1.00e-0585324GO:0038024
GeneOntologyMolecularFunctionNotch binding

DNER NOTCH1 JAG1

1.07e-0527323GO:0005112
GeneOntologyMolecularFunctionglycosaminoglycan binding

SEMA5A THBS1 THBS2 IGFALS SLIT3

6.28e-05268325GO:0005539
GeneOntologyMolecularFunctionsulfur compound binding

SEMA5A THBS1 THBS2 IGFALS SLIT3

1.51e-04323325GO:1901681
GeneOntologyMolecularFunctionRoundabout binding

IGFALS SLIT3

1.63e-0412322GO:0048495
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

PRDM9 PRDM7

1.92e-0413322GO:0046975
GeneOntologyMolecularFunctionheparin binding

THBS1 THBS2 IGFALS SLIT3

2.41e-04192324GO:0008201
GeneOntologyMolecularFunctioninsulin-like growth factor binding

LRP2 IGFALS

4.18e-0419322GO:0005520
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

PRDM9 PRDM7

4.64e-0420322GO:0042800
GeneOntologyMolecularFunctionsemaphorin receptor binding

SEMA5A SEMA5B

6.16e-0423322GO:0030215
GeneOntologyMolecularFunctionchemorepellent activity

SEMA5A SEMA5B

9.83e-0429322GO:0045499
GeneOntologyMolecularFunctionlipoprotein particle binding

VLDLR THBS1

1.43e-0335322GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

VLDLR THBS1

1.43e-0335322GO:0071814
GeneOntologyMolecularFunctiongrowth factor binding

LRP2 THBS1 IGFALS

1.96e-03156323GO:0019838
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

PRDM9 PRDM7

2.26e-0344322GO:0140938
GeneOntologyMolecularFunctionsignaling receptor regulator activity

SEMA5A LYPD1 SEMA5B JAG1 TG

2.78e-03616325GO:0030545
GeneOntologyMolecularFunctionproteoglycan binding

SEMA5A THBS1

3.02e-0351322GO:0043394
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

PRDM9 PRDM7

5.31e-0368322GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

PRDM9 PRDM7

5.46e-0369322GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

PRDM9 PRDM7

5.77e-0371322GO:0042054
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

OBSL1 LRP2 VLDLR SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

1.16e-077483210GO:0048667
GeneOntologyBiologicalProcessneuron projection morphogenesis

OBSL1 LRP2 VLDLR SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

2.21e-078023210GO:0048812
GeneOntologyBiologicalProcessaxon guidance

LRP2 SEMA5A IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

2.24e-07285327GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LRP2 SEMA5A IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

2.29e-07286327GO:0097485
GeneOntologyBiologicalProcesscardiac septum morphogenesis

LRP2 NOTCH1 NOTCH2 JAG1 SLIT3

2.45e-0789325GO:0060411
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

OBSL1 LRP2 VLDLR SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

2.69e-078193210GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

OBSL1 LRP2 VLDLR SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

2.91e-078263210GO:0048858
GeneOntologyBiologicalProcesssemi-lunar valve development

NOTCH1 NOTCH2 JAG1 SLIT3

1.04e-0650324GO:1905314
GeneOntologyBiologicalProcessnegative chemotaxis

SEMA5A IGFALS SEMA5B SLIT3

1.13e-0651324GO:0050919
GeneOntologyBiologicalProcessaxonogenesis

LRP2 SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

1.80e-06566328GO:0007409
GeneOntologyBiologicalProcesscardiac septum development

LRP2 NOTCH1 NOTCH2 JAG1 SLIT3

1.88e-06134325GO:0003279
GeneOntologyBiologicalProcessneuron projection development

OBSL1 LRP2 VLDLR SEMA5A LRP12 NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

2.01e-0612853211GO:0031175
GeneOntologyBiologicalProcessheart valve morphogenesis

NOTCH1 NOTCH2 JAG1 SLIT3

2.66e-0663324GO:0003179
GeneOntologyBiologicalProcesspulmonary valve morphogenesis

NOTCH1 NOTCH2 JAG1

3.80e-0620323GO:0003184
GeneOntologyBiologicalProcessaxon development

LRP2 SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

4.58e-06642328GO:0061564
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

LRP2 NOTCH1 NOTCH2 JAG1 SLIT3

4.62e-06161325GO:0003206
GeneOntologyBiologicalProcessheart valve development

NOTCH1 NOTCH2 JAG1 SLIT3

6.28e-0678324GO:0003170
GeneOntologyBiologicalProcesspulmonary valve development

NOTCH1 NOTCH2 JAG1

6.71e-0624323GO:0003177
GeneOntologyBiologicalProcesscellular response to tumor cell

NOTCH1 NOTCH2

6.99e-063322GO:0071228
GeneOntologyBiologicalProcessneuron development

OBSL1 LRP2 VLDLR SEMA5A LRP12 NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

7.06e-0614633211GO:0048666
GeneOntologyBiologicalProcesscell morphogenesis

OBSL1 LRP2 VLDLR SEMA5A NTNG2 IGFALS SEMA5B NOTCH1 NOTCH2 SLIT3

8.13e-0611943210GO:0000902
GeneOntologyBiologicalProcessregulation of endothelial cell chemotaxis

SEMA5A THBS1 NOTCH1

8.61e-0626323GO:2001026
GeneOntologyBiologicalProcessheart morphogenesis

LRP2 THBS1 NOTCH1 NOTCH2 JAG1 SLIT3

8.74e-06321326GO:0003007
GeneOntologyBiologicalProcesschemotaxis

LRP2 SEMA5A THBS1 IGFALS SEMA5B NOTCH1 SLIT3

1.17e-05517327GO:0006935
GeneOntologyBiologicalProcesstaxis

LRP2 SEMA5A THBS1 IGFALS SEMA5B NOTCH1 SLIT3

1.20e-05519327GO:0042330
GeneOntologyBiologicalProcessoutflow tract morphogenesis

LRP2 THBS1 NOTCH1 JAG1

1.32e-0594324GO:0003151
GeneOntologyBiologicalProcesspositive regulation of reciprocal meiotic recombination

PRDM9 PRDM7

1.40e-054322GO:0010845
GeneOntologyBiologicalProcessregulation of reciprocal meiotic recombination

PRDM9 PRDM7

1.40e-054322GO:0010520
GeneOntologyBiologicalProcesscardiac chamber development

LRP2 NOTCH1 NOTCH2 JAG1 SLIT3

1.76e-05212325GO:0003205
GeneOntologyBiologicalProcessendothelial cell chemotaxis

SEMA5A THBS1 NOTCH1

2.15e-0535323GO:0035767
GeneOntologyBiologicalProcessaortic valve morphogenesis

NOTCH1 JAG1 SLIT3

2.98e-0539323GO:0003180
GeneOntologyBiologicalProcessinhibition of neuroepithelial cell differentiation

NOTCH1 JAG1

3.48e-056322GO:0002085
GeneOntologyBiologicalProcessciliary body morphogenesis

NOTCH2 JAG1

3.48e-056322GO:0061073
GeneOntologyBiologicalProcesspulmonary artery morphogenesis

LRP2 JAG1

3.48e-056322GO:0061156
GeneOntologyBiologicalProcesspositive regulation of nervous system development

OBSL1 LRP2 SEMA5A THBS2 NOTCH1 NOTCH2

3.87e-05418326GO:0051962
GeneOntologyBiologicalProcessregulation of nervous system development

OBSL1 LRP2 SEMA5A THBS2 NOTCH1 NOTCH2 TG

3.94e-05625327GO:0051960
GeneOntologyBiologicalProcessnegative regulation of endothelial cell chemotaxis

THBS1 NOTCH1

4.87e-057322GO:2001027
GeneOntologyBiologicalProcessaortic valve development

NOTCH1 JAG1 SLIT3

4.92e-0546323GO:0003176
GeneOntologyBiologicalProcessepithelial cell differentiation involved in kidney development

NOTCH1 NOTCH2 JAG1

5.25e-0547323GO:0035850
GeneOntologyBiologicalProcessnegative regulation of chemotaxis

SEMA5A THBS1 NOTCH1

7.97e-0554323GO:0050922
GeneOntologyBiologicalProcessatrioventricular node development

NOTCH1 NOTCH2

8.34e-059322GO:0003162
GeneOntologyBiologicalProcesspositive regulation of cardiac epithelial to mesenchymal transition

NOTCH1 JAG1

8.34e-059322GO:0062043
GeneOntologyBiologicalProcesscell differentiation involved in kidney development

NOTCH1 NOTCH2 JAG1

9.38e-0557323GO:0061005
GeneOntologyBiologicalProcessendocardial cushion development

THBS1 NOTCH1 JAG1

9.88e-0558323GO:0003197
GeneOntologyBiologicalProcessglomerular epithelial cell development

NOTCH2 JAG1

1.04e-0410322GO:0072310
GeneOntologyBiologicalProcesscoronary artery morphogenesis

LRP2 NOTCH1

1.04e-0410322GO:0060982
GeneOntologyBiologicalProcesspodocyte development

NOTCH2 JAG1

1.04e-0410322GO:0072015
GeneOntologyBiologicalProcessdistal tubule development

NOTCH1 JAG1

1.04e-0410322GO:0072017
GeneOntologyBiologicalProcesscardiac ventricle development

LRP2 NOTCH1 JAG1 SLIT3

1.08e-04161324GO:0003231
GeneOntologyBiologicalProcessheart development

OBSL1 LRP2 THBS1 NOTCH1 NOTCH2 JAG1 SLIT3

1.32e-04757327GO:0007507
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

OBSL1 LRP2 SEMA5A NOTCH1 NOTCH2

1.99e-04354325GO:0050769
GeneOntologyBiologicalProcessmorphogenesis of an epithelial sheet

NOTCH1 NOTCH2 JAG1

2.04e-0474323GO:0002011
GeneOntologyBiologicalProcessnegative regulation of cell-substrate adhesion

THBS1 NOTCH1 JAG1

2.04e-0474323GO:0010812
GeneOntologyBiologicalProcessleft/right axis specification

NOTCH1 NOTCH2

2.10e-0414322GO:0070986
GeneOntologyBiologicalProcessregulation of cardiac epithelial to mesenchymal transition

NOTCH1 JAG1

2.10e-0414322GO:0062042
GeneOntologyBiologicalProcessblood vessel morphogenesis

LRP2 SEMA5A THBS1 THBS2 NOTCH1 NOTCH2 JAG1

2.11e-04817327GO:0048514
GeneOntologyBiologicalProcessendocytosis

DNER LRP2 VLDLR LRP12 THBS1 LRP1B ARFGAP1

2.27e-04827327GO:0006897
GeneOntologyBiologicalProcessglomerulus development

NOTCH1 NOTCH2 JAG1

2.30e-0477323GO:0032835
GeneOntologyBiologicalProcessregulation of timing of cell differentiation

NOTCH1 JAG1

2.42e-0415322GO:0048505
GeneOntologyBiologicalProcesscirculatory system development

OBSL1 LRP2 SEMA5A THBS1 THBS2 NOTCH1 NOTCH2 JAG1 SLIT3

2.50e-041442329GO:0072359
GeneOntologyBiologicalProcessmesenchyme development

SEMA5A THBS1 SEMA5B NOTCH1 JAG1

2.51e-04372325GO:0060485
GeneOntologyBiologicalProcesskidney development

LRP2 NOTCH1 NOTCH2 JAG1 PYGO1

2.51e-04372325GO:0001822
GeneOntologyBiologicalProcesspositive regulation of neural precursor cell proliferation

LRP2 NOTCH1 NOTCH2

2.57e-0480323GO:2000179
GeneOntologyBiologicalProcessaorta development

LRP2 NOTCH1 JAG1

2.57e-0480323GO:0035904
GeneOntologyBiologicalProcessneuroendocrine cell differentiation

NOTCH1 JAG1

2.76e-0416322GO:0061101
GeneOntologyBiologicalProcessrenal system development

LRP2 NOTCH1 NOTCH2 JAG1 PYGO1

2.97e-04386325GO:0072001
GeneOntologyBiologicalProcessNotch signaling pathway

DNER NOTCH1 NOTCH2 JAG1

3.00e-04210324GO:0007219
GeneOntologyBiologicalProcessregulation of development, heterochronic

NOTCH1 JAG1

3.13e-0417322GO:0040034
GeneOntologyBiologicalProcesscardiac ventricle morphogenesis

LRP2 NOTCH1 JAG1

3.40e-0488323GO:0003208
GeneOntologyBiologicalProcessneural crest cell development

SEMA5A SEMA5B JAG1

3.52e-0489323GO:0014032
GeneOntologyBiologicalProcessventricular septum development

LRP2 NOTCH1 SLIT3

3.76e-0491323GO:0003281
GeneOntologyBiologicalProcessartery morphogenesis

LRP2 NOTCH1 JAG1

3.88e-0492323GO:0048844
GeneOntologyBiologicalProcessblood vessel development

LRP2 SEMA5A THBS1 THBS2 NOTCH1 NOTCH2 JAG1

4.60e-04929327GO:0001568
GeneOntologyBiologicalProcessresponse to muramyl dipeptide

NOTCH1 JAG1

4.81e-0421322GO:0032495
GeneOntologyBiologicalProcesscardiac right ventricle morphogenesis

NOTCH1 JAG1

4.81e-0421322GO:0003215
GeneOntologyBiologicalProcessstem cell development

SEMA5A SEMA5B JAG1

5.10e-04101323GO:0048864
GeneOntologyBiologicalProcesspodocyte differentiation

NOTCH2 JAG1

5.28e-0422322GO:0072112
GeneOntologyBiologicalProcessglomerular epithelial cell differentiation

NOTCH2 JAG1

5.28e-0422322GO:0072311
GeneOntologyBiologicalProcessaxon extension involved in axon guidance

SEMA5A SLIT3

5.28e-0422322GO:0048846
GeneOntologyBiologicalProcessrenal filtration cell differentiation

NOTCH2 JAG1

5.28e-0422322GO:0061318
GeneOntologyBiologicalProcessneuron projection extension involved in neuron projection guidance

SEMA5A SLIT3

5.28e-0422322GO:1902284
GeneOntologyBiologicalProcessneural crest cell differentiation

SEMA5A SEMA5B JAG1

5.55e-04104323GO:0014033
GeneOntologyBiologicalProcessanimal organ morphogenesis

LRP2 THBS1 NTNG2 CHRNA9 NOTCH1 NOTCH2 JAG1 SLIT3

5.59e-041269328GO:0009887
GeneOntologyBiologicalProcessglomerular epithelium development

NOTCH2 JAG1

5.78e-0423322GO:0072010
GeneOntologyBiologicalProcessvasculature development

LRP2 SEMA5A THBS1 THBS2 NOTCH1 NOTCH2 JAG1

5.92e-04969327GO:0001944
GeneOntologyBiologicalProcesstranscytosis

LRP2 TG

6.30e-0424322GO:0045056
GeneOntologyBiologicalProcessnephron tubule development

NOTCH1 NOTCH2 JAG1

6.54e-04110323GO:0072080
GeneOntologyBiologicalProcessangiogenesis

SEMA5A THBS1 THBS2 NOTCH1 NOTCH2 JAG1

6.76e-04708326GO:0001525
GeneOntologyBiologicalProcessdetection of light stimulus involved in visual perception

SEMA5A SEMA5B

6.84e-0425322GO:0050908
GeneOntologyBiologicalProcessdetection of light stimulus involved in sensory perception

SEMA5A SEMA5B

6.84e-0425322GO:0050962
GeneOntologyBiologicalProcesspositive regulation of Ras protein signal transduction

NOTCH1 NOTCH2

6.84e-0425322GO:0046579
GeneOntologyBiologicalProcesspositive regulation of meiotic nuclear division

PRDM9 PRDM7

7.40e-0426322GO:0045836
GeneOntologyBiologicalProcesspositive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

THBS1 NOTCH1 NOTCH2

7.44e-04115323GO:0090100
GeneOntologyBiologicalProcessrenal tubule development

NOTCH1 NOTCH2 JAG1

7.63e-04116323GO:0061326
GeneOntologyBiologicalProcessatrioventricular valve morphogenesis

NOTCH1 SLIT3

8.60e-0428322GO:0003181
GeneOntologyBiologicalProcesspositive regulation of smooth muscle cell differentiation

NOTCH1 NOTCH2

8.60e-0428322GO:0051152
GeneOntologyBiologicalProcessresponse to abiotic stimulus

LRP2 VLDLR SEMA5A THBS1 CHRNA9 SEMA5B NOTCH1 TG

8.88e-041361328GO:0009628
GeneOntologyBiologicalProcessglomerulus vasculature development

NOTCH1 NOTCH2

9.87e-0430322GO:0072012
GeneOntologyBiologicalProcessnephron epithelium development

NOTCH1 NOTCH2 JAG1

1.02e-03128323GO:0072009
GeneOntologyBiologicalProcesskidney vasculature development

NOTCH1 NOTCH2

1.05e-0331322GO:0061440
GeneOntologyCellularComponentreceptor complex

LRP2 VLDLR CHRNA9 LRP1B NOTCH1 NOTCH2

2.20e-04581326GO:0043235
GeneOntologyCellularComponentclathrin-coated pit

LRP2 VLDLR LRP12

2.47e-0480323GO:0005905
DomainEGF_CA

DNER LRP2 VLDLR THBS1 THBS2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

6.70e-171223211SM00179
DomainEGF-like_Ca-bd_dom

DNER LRP2 VLDLR THBS1 THBS2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

8.06e-171243211IPR001881
DomainEGF

DNER LRP2 VLDLR THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

9.66e-171263211PF00008
DomainEGF_3

DNER LRP2 VLDLR THBS1 THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

2.15e-152353212PS50026
DomainEGF

DNER LRP2 VLDLR THBS1 THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

2.15e-152353212SM00181
DomainEGF-like_dom

DNER LRP2 VLDLR THBS1 THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

4.31e-152493212IPR000742
DomainEGF_1

DNER LRP2 VLDLR THBS1 THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

5.74e-152553212PS00022
DomainEGF-like_CS

DNER LRP2 VLDLR THBS1 THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

7.59e-152613212IPR013032
DomainEGF_2

DNER LRP2 VLDLR THBS1 THBS2 NTNG2 LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

9.11e-152653212PS01186
DomainEGF_Ca-bd_CS

DNER LRP2 VLDLR LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

4.78e-1497329IPR018097
DomainEGF_CA

DNER LRP2 VLDLR LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

5.78e-1499329PS01187
DomainEGF-type_Asp/Asn_hydroxyl_site

DNER LRP2 VLDLR LRP1B F9 NOTCH1 NOTCH2 JAG1 SLIT3

1.09e-13106329IPR000152
DomainEGF_CA

LRP2 VLDLR THBS1 THBS2 LRP1B NOTCH1 NOTCH2 JAG1

1.39e-1286328PF07645
DomainASX_HYDROXYL

DNER LRP2 VLDLR LRP1B F9 NOTCH1 NOTCH2 JAG1

4.80e-12100328PS00010
DomainGrowth_fac_rcpt_

DNER LRP2 VLDLR LRP1B NOTCH1 NOTCH2 JAG1 SLIT3

1.75e-10156328IPR009030
DomainEGF_extracell

DNER LRP2 NTNG2 LRP1B NOTCH1 JAG1

7.22e-1060326IPR013111
DomainEGF_2

DNER LRP2 NTNG2 LRP1B NOTCH1 JAG1

7.22e-1060326PF07974
DomainhEGF

DNER NOTCH1 NOTCH2 JAG1

1.41e-0728324PF12661
DomainLDLR_class-A_CS

LRP2 VLDLR LRP12 LRP1B

6.21e-0740324IPR023415
DomainLdl_recept_a

LRP2 VLDLR LRP12 LRP1B

1.01e-0645324PF00057
Domain-

LRP2 VLDLR LRP12 LRP1B

1.10e-06463244.10.400.10
DomainLDLRA_1

LRP2 VLDLR LRP12 LRP1B

1.31e-0648324PS01209
DomainLDrepeatLR_classA_rpt

LRP2 VLDLR LRP12 LRP1B

1.42e-0649324IPR002172
DomainLDLa

LRP2 VLDLR LRP12 LRP1B

1.42e-0649324SM00192
DomainLDLRA_2

LRP2 VLDLR LRP12 LRP1B

1.42e-0649324PS50068
DomainLdl_recept_b

LRP2 VLDLR LRP1B

1.64e-0614323PF00058
DomainLDLRB

LRP2 VLDLR LRP1B

1.64e-0614323PS51120
DomainLY

LRP2 VLDLR LRP1B

2.05e-0615323SM00135
DomainLDLR_classB_rpt

LRP2 VLDLR LRP1B

2.05e-0615323IPR000033
DomainTSP_1

SEMA5A THBS1 THBS2 SEMA5B

3.94e-0663324PF00090
DomainTSP1

SEMA5A THBS1 THBS2 SEMA5B

4.46e-0665324SM00209
DomainTSP1_rpt

SEMA5A THBS1 THBS2 SEMA5B

4.46e-0665324IPR000884
DomainTSP1

SEMA5A THBS1 THBS2 SEMA5B

4.46e-0665324PS50092
DomainDUF3454

NOTCH1 NOTCH2

8.52e-063322PF11936
DomainDUF3454_notch

NOTCH1 NOTCH2

8.52e-063322IPR024600
DomainDUF3454

NOTCH1 NOTCH2

8.52e-063322SM01334
DomainNOD

NOTCH1 NOTCH2

1.70e-054322PF06816
DomainNotch

NOTCH1 NOTCH2

1.70e-054322IPR008297
DomainNODP

NOTCH1 NOTCH2

1.70e-054322PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH2

1.70e-054322IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH2

1.70e-054322IPR010660
DomainNOD

NOTCH1 NOTCH2

1.70e-054322SM01338
DomainNODP

NOTCH1 NOTCH2

1.70e-054322SM01339
DomainLNR

NOTCH1 NOTCH2

2.83e-055322PS50258
DomainTSP3

THBS1 THBS2

2.83e-055322PS51234
DomainTSP_CTER

THBS1 THBS2

2.83e-055322PS51236
Domain-

THBS1 THBS2

2.83e-0553224.10.1080.10
DomainThrombospondin_C

THBS1 THBS2

2.83e-055322IPR008859
DomainTSP_C

THBS1 THBS2

2.83e-055322PF05735
DomainThrombospondin_3_rpt

THBS1 THBS2

2.83e-055322IPR017897
DomainTSP_3

THBS1 THBS2

2.83e-055322PF02412
DomainThrombospondin_3-like_rpt

THBS1 THBS2

2.83e-055322IPR003367
DomainTSP_type-3_rpt

THBS1 THBS2

2.83e-055322IPR028974
DomainVWC

THBS1 THBS2 JAG1

3.70e-0538323SM00214
Domain-

LRP2 VLDLR LRP1B

4.00e-05393232.120.10.30
DomainVWF_dom

THBS1 THBS2 JAG1

5.01e-0542323IPR001007
DomainNotch_dom

NOTCH1 NOTCH2

5.94e-057322IPR000800
DomainNotch

NOTCH1 NOTCH2

5.94e-057322PF00066
DomainNL

NOTCH1 NOTCH2

5.94e-057322SM00004
Domain6-blade_b-propeller_TolB-like

LRP2 VLDLR LRP1B

6.60e-0546323IPR011042
DomainSSXRD

PRDM9 PRDM7

7.91e-058322PF09514
DomainSSXRD_motif

PRDM9 PRDM7

7.91e-058322IPR019041
DomainLaminin_G

THBS1 THBS2 SLIT3

1.32e-0458323IPR001791
DomainKRAB_RELATED

PRDM9 PRDM7

1.55e-0411322PS50806
DomainKrueppel-associated_box-rel

PRDM9 PRDM7

2.19e-0413322IPR003655
DomainSemaphorin

SEMA5A SEMA5B

5.30e-0420322IPR027231
Domain-

THBS1 THBS2 SLIT3

5.68e-04953232.60.120.200
DomainTSPN

THBS1 THBS2

7.04e-0423322SM00210
DomaincEGF

LRP2 LRP1B

9.01e-0426322IPR026823
DomaincEGF

LRP2 LRP1B

9.01e-0426322PF12662
DomainVWC

THBS1 THBS2

1.05e-0328322PF00093
DomainSEMA

SEMA5A SEMA5B

1.28e-0331322PS51004
DomainSema

SEMA5A SEMA5B

1.28e-0331322SM00630
DomainSemap_dom

SEMA5A SEMA5B

1.28e-0331322IPR001627
DomainSema

SEMA5A SEMA5B

1.28e-0331322PF01403
DomainPlexin_repeat

SEMA5A SEMA5B

1.37e-0332322IPR002165
DomainPSI

SEMA5A SEMA5B

1.37e-0332322PF01437
DomainVWFC_1

THBS1 THBS2

1.73e-0336322PS01208
DomainVWFC_2

THBS1 THBS2

1.92e-0338322PS50184
DomainPSI

SEMA5A SEMA5B

2.57e-0344322IPR016201
DomainPSI

SEMA5A SEMA5B

2.81e-0346322SM00423
DomainSET

PRDM9 PRDM7

2.81e-0346322SM00317
DomainSET_dom

PRDM9 PRDM7

3.31e-0350322IPR001214
DomainSET

PRDM9 PRDM7

3.31e-0350322PS50280
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

SEMA5A THBS1 THBS2 SEMA5B NOTCH1 NOTCH2

4.38e-0968296M27303
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DNER NOTCH1 NOTCH2 JAG1

2.45e-0727294M39545
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

SEMA5A THBS1 THBS2 SEMA5B NOTCH1 NOTCH2

3.84e-07143296M27275
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

SEMA5A THBS1 THBS2 SEMA5B

1.13e-0639294M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

SEMA5A THBS1 THBS2 SEMA5B

1.13e-0639294MM15165
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH2 JAG1

1.70e-0612293M47532
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH2 JAG1

2.21e-0613293M47423
PathwayPID_NOTCH_PATHWAY

DNER NOTCH1 NOTCH2 JAG1

6.08e-0659294M17
PathwayREACTOME_DISEASES_OF_METABOLISM

SEMA5A THBS1 THBS2 SEMA5B NOTCH1 NOTCH2

9.88e-06250296M27554
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

DNER NOTCH1 JAG1

3.38e-0531293M592
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH2

4.07e-055292M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH2

6.10e-056292M27068
PathwayREACTOME_O_LINKED_GLYCOSYLATION

SEMA5A THBS1 THBS2 SEMA5B

6.92e-05109294MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

SEMA5A THBS1 THBS2 SEMA5B

7.43e-05111294M27416
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

NOTCH1 JAG1

8.53e-057292M27199
PathwayWP_NOTCH_SIGNALING_WP268

NOTCH1 NOTCH2 JAG1

1.05e-0445293M39571
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

DNER LRP2 VLDLR LRP12 LRP1B ACOX3

1.05e-04381296M48063
PathwayWP_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH2 JAG1

1.12e-0446293MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH2 JAG1

1.19e-0447293M7946
PathwayWP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM

VLDLR NOTCH1 JAG1

2.13e-0457293M48326
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH2

2.22e-0411292M47865
PathwayWP_NOTCH_SIGNALING_WP61

NOTCH1 NOTCH2 JAG1

2.60e-0461293M39540
PathwayBIOCARTA_HES_PATHWAY

NOTCH1 NOTCH2

2.66e-0412292MM1562
PathwayBIOCARTA_HES_PATHWAY

NOTCH1 NOTCH2

2.66e-0412292M22042
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH2

2.66e-0412292M47533
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH2

3.14e-0413292M47534
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

NOTCH1 JAG1

3.66e-0414292M27808
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

NOTCH1 JAG1

4.22e-0415292M27202
PathwayWP_AXON_GUIDANCE

NTNG2 SEMA5B SLIT3

4.24e-0472293M48335
PathwayREACTOME_SIGNALING_BY_NOTCH1

DNER NOTCH1 JAG1

4.60e-0474293M616
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

OBSL1 SEMA5A THBS1 THBS2 LYPD1 NTNG2 SEMA5B F9 ANO8 ARFGAP1

4.72e-0414752910M19806
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

NOTCH1 JAG1

4.82e-0416292M47424
PathwayWP_AMPLIFICATION_AND_EXPANSION_OF_ONCOGENIC_PATHWAYS_AS_METASTATIC_TRAITS

NOTCH1 JAG1

5.45e-0417292M39443
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

NOTCH1 JAG1

5.45e-0417292M39389
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH2

6.13e-0418292M614
PathwayWP_NEPHROGENESIS

NOTCH2 JAG1

6.13e-0418292M40045
PathwayREACTOME_SIGNALING_BY_NOTCH4

NOTCH1 NOTCH2 JAG1

6.21e-0482293M594
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH2 JAG1

6.21e-0482293MM15922
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

NOTCH1 NOTCH2

7.59e-0420292M27881
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

NOTCH2 JAG1

9.20e-0422292M27210
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH1 NOTCH2

1.10e-0324292M11190
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH2

1.49e-0328292M6177
PathwayREACTOME_SIGNALING_BY_NOTCH

DNER NOTCH1 NOTCH2 JAG1

1.52e-03246294M10189
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

NOTCH1 NOTCH2 JAG1

1.78e-03118293M39852
PathwayPID_INTEGRIN_A4B1_PATHWAY

THBS1 THBS2

2.07e-0333292M277
PathwayREACTOME_SIGNALING_BY_NOTCH2

NOTCH2 JAG1

2.07e-0333292M604
PathwayWP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT

NOTCH1 NOTCH2

2.20e-0334292M39390
PathwayKEGG_AXON_GUIDANCE

SEMA5A SEMA5B SLIT3

2.30e-03129293M5539
PathwayWP_NEOVASCULARIZATION_PROCESSES

NOTCH1 JAG1

2.60e-0337292M39506
PathwayREACTOME_SIGNALING_BY_NOTCH

NOTCH1 JAG1

2.89e-0339292MM14604
PathwayWP_MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS

THBS1 THBS2

3.50e-0343292M39565
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP2 LRP12

3.83e-0345292MM15344
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

NOTCH1 NOTCH2 JAG1

4.30e-03161293M39770
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP2 LRP12

4.35e-0348292M27642
PathwayREACTOME_SIGNALING_BY_NOTCH3

NOTCH1 JAG1

4.53e-0349292M618
PathwayWP_PRIMARY_OVARIAN_INSUFFICIENCY

PRDM9 NOTCH2 TG

5.33e-03174293M48058
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

SEMA5A THBS1 THBS2 LYPD1 SEMA5B F9 ANO8 ARFGAP1

5.66e-031389298MM15307
PathwayREACTOME_SIGNALING_BY_PDGF

THBS1 THBS2

6.08e-0357292MM14713
PathwayREACTOME_SIGNALING_BY_PDGF

THBS1 THBS2

6.29e-0358292M2049
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

NOTCH1 JAG1

6.29e-0358292M29616
PathwayWP_MARKERS_OF_KIDNEY_CELL_LINEAGE

NOTCH1 JAG1

6.50e-0359292M46460
PathwayWP_DYRK1A_INVOLVEMENT_REGARDING_CELL_PROLIFERATION_IN_BRAIN_DEVELOPMENT

DNER NOTCH1

7.16e-0362292M45532
Pubmed

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells.

VLDLR THBS1 THBS2

7.07e-10332318032585
Pubmed

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.

NOTCH1 NOTCH2 JAG1

7.07e-10332314726396
Pubmed

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.

NOTCH1 NOTCH2 JAG1 SLIT3

2.26e-091932425691540
Pubmed

Thrombospondin 2 potentiates notch3/jagged1 signaling.

THBS1 THBS2 JAG1

2.83e-09432319147503
Pubmed

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes.

NOTCH1 NOTCH2 JAG1

2.83e-09432322390640
Pubmed

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.

NOTCH1 NOTCH2 JAG1

2.83e-09432330226866
Pubmed

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.

NOTCH1 NOTCH2 JAG1

2.83e-09432310551863
Pubmed

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.

NOTCH1 NOTCH2 JAG1

2.83e-09432324398584
Pubmed

Functional diversity of notch family genes in fetal lung development.

NOTCH1 NOTCH2 JAG1

7.07e-09532315064243
Pubmed

The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.

NOTCH1 NOTCH2 JAG1

7.07e-09532311713346
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

NOTCH1 NOTCH2 JAG1

7.07e-09532315882997
Pubmed

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.

NOTCH1 NOTCH2 JAG1

7.07e-09532327118257
Pubmed

Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice.

NOTCH1 NOTCH2 JAG1

7.07e-09532335064244
Pubmed

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.

NOTCH1 NOTCH2 JAG1

1.41e-08632310958687
Pubmed

Characterization of Notch receptor expression in the developing mammalian heart and liver.

NOTCH1 NOTCH2 JAG1

1.41e-08632312244553
Pubmed

Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.

NOTCH1 NOTCH2 JAG1

1.41e-08632322526456
Pubmed

Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors.

NOTCH1 NOTCH2 JAG1

1.41e-08632315226394
Pubmed

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.

VLDLR NOTCH1 NOTCH2

1.41e-08632318957219
Pubmed

Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura.

NOTCH1 NOTCH2 JAG1

1.41e-08632319603167
Pubmed

Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4.

NOTCH1 NOTCH2 JAG1

1.41e-0863239108364
Pubmed

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

NOTCH1 NOTCH2 JAG1

1.41e-08632331071093
Pubmed

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

NOTCH1 NOTCH2 JAG1

2.47e-08732310383933
Pubmed

Human ligands of the Notch receptor.

NOTCH1 NOTCH2 JAG1

2.47e-08732310079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

NOTCH1 NOTCH2 JAG1

2.47e-08732312846471
Pubmed

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.

NOTCH1 NOTCH2 JAG1

2.47e-08732324711412
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

LRP2 VLDLR LRP1B NOTCH1 NOTCH2

3.54e-0810132523382219
Pubmed

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.

NOTCH1 NOTCH2 JAG1

3.95e-08832319914235
Pubmed

Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.

NOTCH1 NOTCH2 JAG1

3.95e-08832322156581
Pubmed

P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.

NOTCH1 NOTCH2 JAG1

3.95e-08832322652674
Pubmed

Notch1 and Jagged1 expression by the developing pulmonary vasculature.

NOTCH1 NOTCH2 JAG1

3.95e-08832312242716
Pubmed

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis.

NOTCH1 NOTCH2 JAG1

3.95e-08832315465493
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

NOTCH1 NOTCH2 JAG1

3.95e-0883239858718
Pubmed

High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.

NOTCH1 NOTCH2 JAG1

3.95e-08832315068794
Pubmed

Notch/Delta expression in the developing mouse lung.

NOTCH1 NOTCH2 JAG1

3.95e-08832311044610
Pubmed

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.

LRP2 NOTCH1 NOTCH2 JAG1

5.27e-084032423362348
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

NOTCH1 NOTCH2 JAG1

5.92e-08932311118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

NOTCH1 NOTCH2 JAG1

5.92e-08932316245338
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

NOTCH1 NOTCH2 JAG1

8.45e-081032323665443
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

NOTCH1 NOTCH2 JAG1

8.45e-081032324015274
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

NOTCH1 NOTCH2 JAG1

1.16e-071132315499562
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

NOTCH1 NOTCH2 JAG1

1.16e-071132310878608
Pubmed

Defects in somite formation in lunatic fringe-deficient mice.

NOTCH1 NOTCH2 JAG1

1.16e-07113239690472
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

NOTCH1 NOTCH2 JAG1

1.16e-07113239187150
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

NOTCH1 NOTCH2 JAG1

1.16e-071132312866128
Pubmed

Notch signaling promotes nephrogenesis by downregulating Six2.

NOTCH1 NOTCH2 JAG1

1.55e-071232327633993
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

NOTCH1 NOTCH2 JAG1

1.55e-071232315465494
Pubmed

Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development.

NOTCH1 NOTCH2 JAG1

1.55e-071232332147304
Pubmed

Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression.

NOTCH1 NOTCH2 JAG1

1.55e-071232314732396
Pubmed

Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.

NOTCH1 NOTCH2 JAG1

1.55e-071232317572911
Pubmed

Node and midline defects are associated with left-right development in Delta1 mutant embryos.

NOTCH1 NOTCH2 JAG1

2.01e-071332312441287
Pubmed

Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.

NOTCH1 NOTCH2 JAG1

2.01e-071332331202705
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

NOTCH1 NOTCH2 JAG1

2.01e-071332311578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

NOTCH1 NOTCH2 JAG1

2.01e-071332320558824
Pubmed

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

NOTCH1 NOTCH2 JAG1

2.56e-071432323806616
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP2 VLDLR LRP1B

2.56e-071432315082773
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

NOTCH1 NOTCH2 JAG1

2.56e-071432314757642
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

THBS1 THBS2 NOTCH1 JAG1

2.59e-075932421421844
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

NOTCH1 NOTCH2 JAG1

3.19e-071532312971992
Pubmed

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.

NOTCH1 NOTCH2 JAG1

3.19e-071532312167404
Pubmed

COUP-TFI controls Notch regulation of hair cell and support cell differentiation.

NOTCH1 NOTCH2 JAG1

3.19e-071532316914494
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

NOTCH1 NOTCH2 JAG1

3.93e-071632312617809
Pubmed

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

NOTCH1 NOTCH2 JAG1

3.93e-071632317229764
Pubmed

Notch gene expression during pancreatic organogenesis.

NOTCH1 NOTCH2 JAG1

3.93e-071632310842072
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

NOTCH1 NOTCH2 JAG1

3.93e-071632317273555
Pubmed

The Cellular Prion Protein Controls Notch Signaling in Neural Stem/Progenitor Cells.

NOTCH1 NOTCH2 JAG1

3.93e-071632327641601
Pubmed

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.

NOTCH1 NOTCH2 JAG1

3.93e-071632320007915
Pubmed

Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.

NOTCH1 NOTCH2 JAG1

3.93e-071632319185577
Pubmed

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice.

NOTCH1 NOTCH2 JAG1

3.93e-071632332161758
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

NOTCH1 NOTCH2 JAG1

4.77e-071732318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

NOTCH1 NOTCH2 JAG1

4.77e-071732315821257
Pubmed

Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens.

NOTCH1 NOTCH2 JAG1

4.77e-071732330059908
Pubmed

Notch signalling controls pancreatic cell differentiation.

NOTCH1 NOTCH2 JAG1

4.77e-071732310476967
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP2 LRP12 THBS1 PRDM7

5.49e-077132433541421
Pubmed

Notch Signaling Pathway in Tooth Shape Variations throughout Evolution.

NOTCH1 NOTCH2 JAG1

5.72e-071832336899896
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

NOTCH1 NOTCH2 JAG1

5.72e-071832318093989
Pubmed

Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development.

NOTCH1 NOTCH2 JAG1

5.72e-071832328455376
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

NOTCH1 NOTCH2 JAG1

5.72e-071832315689374
Pubmed

Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation.

NOTCH1 NOTCH2 JAG1

5.72e-071832329113990
Pubmed

Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development.

NOTCH1 NOTCH2 JAG1

6.79e-071932321302255
Pubmed

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

NOTCH1 NOTCH2 JAG1

6.79e-071932320335360
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

NOTCH1 NOTCH2 JAG1

6.79e-071932316518823
Pubmed

Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.

LRP2 NOTCH1 JAG1

6.79e-071932334667084
Pubmed

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation.

NOTCH1 NOTCH2 JAG1

6.79e-071932322675211
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

SEMA5A THBS1 THBS2 SEMA5B

6.85e-077532420637190
Pubmed

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.

NOTCH1 NOTCH2 JAG1

7.98e-072032323314057
Pubmed

Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.

NOTCH1 JAG1 SLIT3

7.98e-072032329961574
Pubmed

Up-regulated expression of Notch1 and Jagged1 in human colon adenocarcinoma.

NOTCH1 JAG1

8.20e-07232221145176
Pubmed

A role for notch signaling in human corneal epithelial cell differentiation and proliferation.

NOTCH1 NOTCH2

8.20e-07232217652726
Pubmed

Induced thrombospondin expression in the mouse pancreas during pancreatic injury.

THBS1 THBS2

8.20e-07232216181801
Pubmed

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.

NOTCH1 NOTCH2

8.20e-07232224508387
Pubmed

Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.

THBS1 THBS2

8.20e-07232217620335
Pubmed

Clinical role of Notch signaling pathway in intraductal papillary mucinous neoplasm of the pancreas.

NOTCH1 NOTCH2

8.20e-07232225041344
Pubmed

Notch controls generation and function of human effector CD8+ T cells.

NOTCH1 NOTCH2

8.20e-07232223380742
Pubmed

Human cytomegalovirus infection modulates thrombospondins 1 and 2 in primary fetal astrocytes.

THBS1 THBS2

8.20e-07232223660684
Pubmed

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

NOTCH1 NOTCH2

8.20e-07232225866967
Pubmed

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking.

NOTCH1 NOTCH2

8.20e-07232232423029
Pubmed

Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.

THBS1 THBS2

8.20e-07232239122122
Pubmed

Studies on sporadic non-syndromic thoracic aortic aneurysms: 1. Deregulation of Jagged/Notch 1 homeostasis and selection of synthetic/secretor phenotype smooth muscle cells.

NOTCH1 JAG1

8.20e-07232229708032
Pubmed

Differential Notch1 and Notch2 expression and frequent activation of Notch signaling in gastric cancers.

NOTCH1 NOTCH2

8.20e-07232221466361
Pubmed

Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.

THBS1 THBS2

8.20e-07232234425286
InteractionIGFL3 interactions

LRP2 VLDLR LRP12 LRP1B NOTCH1 NOTCH2

1.82e-0975326int:IGFL3
InteractionNTN5 interactions

LRP2 LRP1B NOTCH1 NOTCH2

5.44e-0824324int:NTN5
InteractionJAG1 interactions

THBS1 NOTCH1 NOTCH2 JAG1

5.09e-0741324int:JAG1
InteractionSEC61B interactions

LRP2 VLDLR TMEM201 VEZT LRP1B NOTCH1 NOTCH2 ANO8 ARFGAP1

1.95e-06763329int:SEC61B
InteractionTHBS2 interactions

THBS1 THBS2 SLIT3

3.46e-0619323int:THBS2
InteractionMFNG interactions

NOTCH1 NOTCH2 JAG1

1.04e-0527323int:MFNG
InteractionDYRK1A interactions

OBSL1 LRP2 TRIM66 VLDLR THBS1 LRP1B NOTCH2

2.07e-05552327int:DYRK1A
InteractionDLK2 interactions

LRP2 VEZT NOTCH1

2.51e-0536323int:DLK2
InteractionJAG2 interactions

LYPD1 NOTCH1 NOTCH2 JAG1

2.69e-05110324int:JAG2
InteractionZDHHC15 interactions

LRP2 LRP12 THBS1 PRDM7

4.43e-05125324int:ZDHHC15
InteractionNOTCH2 interactions

OBSL1 TRIM66 LYPD1 NOTCH1 NOTCH2 JAG1

4.71e-05423326int:NOTCH2
InteractionTHBS1 interactions

LRP2 THBS1 THBS2 JAG1

4.72e-05127324int:THBS1
InteractionDKK2 interactions

LRP2 LRP1B NOTCH1

6.38e-0549323int:DKK2
InteractionFOXD4L6 interactions

LRP1B NOTCH1 NOTCH2

6.38e-0549323int:FOXD4L6
InteractionDNER interactions

DNER NOTCH1

6.80e-058322int:DNER
InteractionZNF408 interactions

LRP2 VLDLR LRP1B NOTCH2

7.90e-05145324int:ZNF408
InteractionLRP2 interactions

LRP2 THBS1 LRP1B TG

9.98e-05154324int:LRP2
InteractionZFP41 interactions

LRP2 LRP1B NOTCH2

1.00e-0457323int:ZFP41
InteractionANKRD36B interactions

LRP2 VLDLR LRP1B

1.17e-0460323int:ANKRD36B
InteractionSLIT3 interactions

THBS2 SLIT3

1.33e-0411322int:SLIT3
InteractionFBN2 interactions

TRIM66 THBS1 NOTCH2

1.49e-0465323int:FBN2
InteractionZNF611 interactions

OBSL1 NOTCH2

1.60e-0412322int:ZNF611
InteractionLGALS1 interactions

LRP2 THBS1 NOTCH1 NOTCH2 JAG1

1.64e-04332325int:LGALS1
InteractionRNASE4 interactions

LRP1B NOTCH2

2.20e-0414322int:RNASE4
InteractionIGSF5 interactions

NOTCH1 NOTCH2

2.20e-0414322int:IGSF5
InteractionTG interactions

LRP2 TG

2.20e-0414322int:TG
InteractionLFNG interactions

NOTCH1 NOTCH2

2.20e-0414322int:LFNG
InteractionAPBB1 interactions

LRP2 F9 NOTCH1 JAG1

2.47e-04195324int:APBB1
InteractionSEMA5B interactions

OBSL1 SEMA5B

2.53e-0415322int:SEMA5B
InteractionTRIM66 interactions

TRIM66 VLDLR VEZT NOTCH2

2.99e-04205324int:TRIM66
InteractionMAML2 interactions

NOTCH1 NOTCH2

3.27e-0417322int:MAML2
InteractionTIMP3 interactions

LRP2 LRP1B NOTCH2

3.89e-0490323int:TIMP3
InteractionMDK interactions

OBSL1 LRP2 NOTCH2

4.02e-0491323int:MDK
InteractionCCN6 interactions

NOTCH1 NOTCH2

4.11e-0419322int:CCN6
InteractionFBXO2 interactions

LRP2 LRP1B NOTCH1 NOTCH2 JAG1

4.40e-04411325int:FBXO2
InteractionMAML3 interactions

NOTCH1 NOTCH2

4.56e-0420322int:MAML3
InteractionZNF224 interactions

LRP2 LRP1B

4.56e-0420322int:ZNF224
InteractionEGFL6 interactions

LRP2 LRP1B

5.03e-0421322int:EGFL6
InteractionCASR interactions

NOTCH1 NOTCH2

5.53e-0422322int:CASR
InteractionDTX4 interactions

NOTCH1 NOTCH2

5.53e-0422322int:DTX4
InteractionWNT2 interactions

NOTCH1 NOTCH2

6.05e-0423322int:WNT2
InteractionSYT1 interactions

LRP2 VLDLR LRP1B

6.11e-04105323int:SYT1
InteractionDAB1 interactions

LRP2 VLDLR NOTCH1

6.45e-04107323int:DAB1
InteractionLRP5 interactions

THBS1 LYPD1 F9

6.81e-04109323int:LRP5
InteractionNOTCH3 interactions

NOTCH1 NOTCH2 JAG1

7.56e-04113323int:NOTCH3
InteractionTMEM268 interactions

TMEM201 CHRNA9

8.36e-0427322int:TMEM268
InteractionTNFAIP6 interactions

LRP2 THBS1

8.36e-0427322int:TNFAIP6
InteractionSULF2 interactions

LRP2 LRP1B NOTCH2

8.79e-04119323int:SULF2
InteractionFEZF1 interactions

LRP2 LRP1B

9.00e-0428322int:FEZF1
InteractionPLXNA4 interactions

SEMA5A SEMA5B

9.00e-0428322int:PLXNA4
InteractionZNF517 interactions

LRP2 LRP1B

9.65e-0429322int:ZNF517
InteractionGLI4 interactions

LRP2 LRP1B NOTCH2

1.01e-03125323int:GLI4
InteractionCFC1 interactions

THBS1 NOTCH1 NOTCH2

1.04e-03126323int:CFC1
Cytoband2q21.2

LYPD1 LRP1B

4.26e-05143222q21.2
GeneFamilyLow density lipoprotein receptors

LRP2 VLDLR LRP12 LRP1B

9.55e-1013214634
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM9 PRDM7

1.73e-04172121197
GeneFamilyImmunoglobulin like domain containing|Semaphorins

SEMA5A SEMA5B

2.41e-0420212736
GeneFamilyPHD finger proteins

TRIM66 PYGO1

4.84e-039021288
CoexpressionBRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS

NOTCH1 NOTCH2 JAG1

9.22e-088323M9884
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

NOTCH1 NOTCH2 JAG1

9.16e-0716323M2207
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

NOTCH1 NOTCH2 JAG1

9.16e-0716323MM1296
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 THBS2 NTNG2 IGFALS SLIT3

3.35e-06191325MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

THBS1 THBS2 NTNG2 IGFALS SLIT3

3.80e-06196325M3008
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL2A

OBSL1 LRP2 LYPD1 SEMA5B NOTCH1 NOTCH2 JAG1

6.51e-06600327M39055
CoexpressionHALLMARK_NOTCH_SIGNALING

NOTCH1 NOTCH2 JAG1

8.00e-0632323M5903
CoexpressionNABA_CORE_MATRISOME

THBS1 THBS2 NTNG2 IGFALS SLIT3

1.79e-05270325MM17057
CoexpressionNABA_CORE_MATRISOME

THBS1 THBS2 NTNG2 IGFALS SLIT3

1.96e-05275325M5884
CoexpressionNABA_MATRISOME

SEMA5A THBS1 THBS2 NTNG2 IGFALS SEMA5B F9 SLIT3

2.15e-051008328MM17056
CoexpressionNABA_MATRISOME

SEMA5A THBS1 THBS2 NTNG2 IGFALS SEMA5B F9 SLIT3

2.44e-051026328M5889
CoexpressionFOROUTAN_PRODRANK_TGFB_EMT_UP

THBS1 CHRNA9 JAG1 ARFGAP1

7.40e-05185324M42503
CoexpressionVERRECCHIA_RESPONSE_TO_TGFB1_C4

THBS1 THBS2

7.89e-0511322M566
CoexpressionHEBERT_MATRISOME_TNBC_BONE_METASTASIS

THBS1 F9

7.89e-0511322M47997
CoexpressionWU_APOPTOSIS_BY_CDKN1A_NOT_VIA_TP53

VEZT F9

7.89e-0511322M6312
CoexpressionFOROUTAN_TGFB_EMT_UP

THBS1 CHRNA9 JAG1 ARFGAP1

8.55e-05192324M42501
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

THBS1 THBS2 NOTCH2 SLIT3

1.00e-04200324M5930
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL2B

OBSL1 LRP2 LYPD1 NOTCH1 NOTCH2

1.79e-04439325M39054
CoexpressionMOREIRA_RESPONSE_TO_TSA_DN

NOTCH1 NOTCH2

2.18e-0418322M3506
CoexpressionBENPORATH_SOX2_TARGETS

OBSL1 LRP2 THBS2 LYPD1 NOTCH1 ANO8

2.30e-04734326M3835
CoexpressionLIM_MAMMARY_STEM_CELL_UP

SEMA5A THBS1 TMEM201 JAG1 SLIT3

2.67e-04479325M2573
CoexpressionBRAUNE_GEIST_20_GENE_NOTCH_SIG_BREAST_CANCER

SEMA5B JAG1

2.71e-0420322M48357
CoexpressionBOQUEST_STEM_CELL_UP

THBS2 LRP1B NOTCH2 SLIT3

2.77e-04261324M1834
CoexpressionLIM_MAMMARY_STEM_CELL_UP

SEMA5A THBS1 TMEM201 JAG1 SLIT3

2.78e-04483325MM1082
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5

LRP2 SEMA5A JAG1

3.09e-04108323M1281
CoexpressionCLIMENT_BREAST_CANCER_COPY_NUMBER_UP

JAG1 TG

3.60e-0423322M13910
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5

LRP2 SEMA5A JAG1

4.01e-04118323MM536
CoexpressionFOROUTAN_INTEGRATED_TGFB_EMT_UP

THBS1 CHRNA9 JAG1

4.21e-04120323M42505
CoexpressionLU_TUMOR_ANGIOGENESIS_UP

NOTCH1 JAG1

4.26e-0425322M9946
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_VASCULAR_SMC_1_CELL

SEMA5A SEMA5B JAG1

4.64e-04124323M45686
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN

THBS1 NOTCH1 NOTCH2

5.94e-04135323M5825
CoexpressionNABA_MATRISOME_METASTATIC_COLORECTAL_LIVER_METASTASIS

THBS2 IGFALS

6.15e-0430322M47990
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL2C

DNER LYPD1 LRP1B NOTCH1

6.34e-04325324M39053
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500

LRP2 VLDLR SEMA5A NOTCH1 NOTCH2 JAG1

2.50e-05398326gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_500

LRP2 VLDLR SEMA5A NOTCH2 JAG1 SLIT3

5.35e-05456326gudmap_kidney_P0_JuxtaGlom_Ren1_500
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000

OBSL1 MGAM VLDLR SEMA5A THBS2 SLIT3 ARFGAP1

1.54e-04799327gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlasEB blastocyst_vs_EB bone marrow-Confounder_removed-fold2.0_adjp0.05

DNER THBS2 LYPD1 SEMA5B JAG1

1.54e-04345325PCBC_ratio_EB blastocyst_vs_EB bone marrow_cfr-2X-p05
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#3

DNER LRP2 SEMA5A LYPD1 LRP1B SLIT3 PYGO1 TG

1.68e-041094328ratio_EB_vs_SC_2500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000

DNER SEMA5A LRP12 THBS1 VEZT JAG1 PYGO1

2.03e-04836327gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_top-relative-expression-ranked_500

DNER MGAM VLDLR SEMA5A THBS2

2.89e-04395325gudmap_developingGonad_P2_epididymis_500
CoexpressionAtlasDevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_top-relative-expression-ranked_100

SEMA5A THBS1 THBS2

2.92e-0486323gudmap_developingKidney_e15.5_Pelvic Mesenchyme_100
CoexpressionAtlasDevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#2_top-relative-expression-ranked_100

SEMA5A THBS1

2.95e-0417322gudmap_developingKidney_e15.5_Pelvic Mesenchyme_100_k2
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_500

OBSL1 MGAM VLDLR SEMA5A THBS2

3.21e-04404325gudmap_developingGonad_e18.5_epididymis_500
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

LRP2 VLDLR SEMA5A THBS1 NOTCH2 JAG1 SLIT3

3.30e-04905327gudmap_kidney_P0_JuxtaGlom_Ren1_1000
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_2500_k-means-cluster#2

DNER LRP2 SEMA5A THBS2 LYPD1 SLIT3 PYGO1

4.45e-04951327Arv_EB-LF_2500_K2
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

SEMA5A THBS1 THBS2 JAG1 SLIT3

4.99e-04445325GSM777043_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_500

DNER SEMA5A LRP12 PYGO1

5.13e-04249324gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500_k3
CoexpressionAtlasStromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2

SEMA5A THBS1 THBS2 JAG1 SLIT3

5.41e-04453325GSM777067_500
CoexpressionAtlasStromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4

SEMA5A THBS1 THBS2 JAG1 SLIT3

5.52e-04455325GSM777055_500
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_EmbryoidBody_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000

DNER LRP2 SEMA5A SEMA5B LRP1B SLIT3 PYGO1

5.53e-04986327PCBC_EB_fibroblast_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_EmbryoidBody_top-relative-expression-ranked_1000

DNER LRP2 LYPD1 SEMA5B LRP1B SLIT3 PYGO1

5.80e-04994327PCBC_EB_1000
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

SEMA5A THBS2 SEMA5B JAG1 SLIT3

2.10e-07186325cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

SEMA5A THBS1 THBS2 JAG1 SLIT3

2.16e-07187325464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VLDLR SEMA5A SEMA5B JAG1 SLIT3

2.28e-07189325d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

SEMA5A THBS2 SEMA5B JAG1 SLIT3

2.40e-0719132578c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A LYPD1 SEMA5B JAG1 SLIT3

2.53e-0719332547d189bac0ef4df2f5c6dd987e46aca85bd7e2af
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DNER SEMA5A LYPD1 SEMA5B

4.52e-061553243b8def9e8f66511736ea37f259511f7c8b7743af
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THBS2 SEMA5B NOTCH2 SLIT3

6.67e-061713244ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNER VLDLR THBS2 LYPD1

6.67e-0617132415cb4670ff4234ac46aea8a5911138d6913c4482
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA5A SEMA5B JAG1 SLIT3

7.14e-06174324015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA5A SEMA5B JAG1 SLIT3

7.81e-06178324066dbc4cc2083c549d98122ed44707127f34d582
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THBS2 F9 JAG1 SLIT3

8.71e-06183324b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VLDLR SEMA5A SEMA5B SLIT3

8.90e-061843244d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A LYPD1 SEMA5B SLIT3

9.29e-061863240b2ce9b8a4382d583240647217ad5e2d3fa555c1
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A SEMA5B JAG1 SLIT3

9.29e-061863244780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A LYPD1 SEMA5B JAG1

9.29e-06186324db4d9ac89cc1e55062ba888b3410b773340595dd
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THBS2 SEMA5B JAG1 SLIT3

9.29e-06186324a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS1 THBS2 LRP1B SLIT3

9.29e-061863247582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SEMA5A SEMA5B JAG1 SLIT3

9.49e-061873241aebf6fab40b96f2f5feb77a302bb805838fccf3
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LYPD1 SEMA5B JAG1 SLIT3

9.49e-06187324d52f7bc0afcdc366b20d199ab33c4ec60ed22a68
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A LYPD1 SEMA5B SLIT3

9.69e-061883240a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEMA5A SEMA5B JAG1 SLIT3

9.89e-061893249c2492c38f27e4c699b40680652e4c64911cce52
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

9.89e-06189324e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA5A THBS2 SEMA5B JAG1

1.01e-051903247df63e5e0dd395676f4fc18cad0d8b2428390943
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LYPD1 SEMA5B JAG1 SLIT3

1.01e-05190324a7f6c38bbf451f166febb21e6719d4afced4035e
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THBS2 SEMA5B JAG1 SLIT3

1.01e-0519032473d94fbae92029745989a8712eed8b99fd84c193
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SEMA5A SEMA5B JAG1 SLIT3

1.01e-05190324d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA5A THBS2 SEMA5B JAG1

1.01e-05190324140aca04c044cd7a93f81ff1631b00b5216d2cb1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DNER SEMA5A THBS1 THBS2

1.01e-051903244f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

1.01e-0519032445df8fee00f8949937863159d7aa042e72748d9b
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

1.01e-05190324d60395739458d7f47a3350ade751fe3819500320
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

1.03e-05191324b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNER THBS2 LYPD1 SLIT3

1.03e-051913249f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

SEMA5A SEMA5B JAG1 SLIT3

1.03e-05191324fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LYPD1 SEMA5B JAG1 SLIT3

1.03e-05191324239c1e68eb1cbe3e137a99fbd6eeb8d64c919ffd
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

1.05e-05192324162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LYPD1 SEMA5B JAG1 SLIT3

1.05e-05192324dee97f650ae6f4d07a142ade402aae1905791a22
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SEMA5A SEMA5B JAG1 SLIT3

1.05e-05192324a7d08416f07f29ad920168a3b52ddf992f263bf4
ToppCellLPS-IL1RA-Stromal_mesenchymal|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

1.05e-051923244e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA5A THBS1 THBS2 SLIT3

1.05e-05192324ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SEMA5A THBS2 SEMA5B JAG1

1.07e-05193324000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNER THBS1 THBS2 SLIT3

1.07e-05193324261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SEMA5A SEMA5B JAG1 SLIT3

1.07e-05193324ba6eb29478d16589172f48f9992e5116328c81d6
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNER THBS2 LYPD1 SLIT3

1.07e-05193324051f61156b0e2e95292b2d8377faf3190b50f264
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

OBSL1 SEMA5A LYPD1 NOTCH2

1.10e-051943247c6c0376603e5fcb64814fd6204d153629c2fbf5
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A LYPD1 SEMA5B JAG1

1.10e-051943247a7406c3b021aeafde423d20290c681c3e8ea0a6
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNER SEMA5A THBS2 SLIT3

1.10e-05194324439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell18-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

SEMA5A SEMA5B JAG1 SLIT3

1.12e-05195324e0ee7905499ee1a1ca7b1184e2713028cf156985
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNER THBS1 THBS2 SLIT3

1.12e-05195324fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A LYPD1 SEMA5B JAG1

1.12e-051953249b3fa1d42ec5aa2911f27a99cd8b57714c6bd604
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SEMA5A SEMA5B JAG1 SLIT3

1.14e-0519632440cae477b3906623d1f2a4c630279e710499ce80
ToppCellwk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DNER SEMA5A THBS2 SEMA5B

1.14e-05196324eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS2 SEMA5B JAG1 SLIT3

1.16e-051973246668f0da54f3bf96769275e668cd57e00b8a5ef9
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

THBS2 SEMA5B NOTCH1 NOTCH2

1.16e-051973249d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

THBS2 SEMA5B NOTCH1 NOTCH2

1.16e-0519732461749ccafeb938c310cff1de5ff924a1c794325a
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OBSL1 THBS2 LRP1B SLIT3

1.16e-0519732417344464fdcc5ba0c03959696b97c195f11e644c
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-Pericytes-Pericyte|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A SEMA5B JAG1 SLIT3

1.16e-05197324452be45f4aac8459dd860493171f5f715368d663
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNER THBS1 THBS2 SLIT3

1.16e-05197324ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS2 SEMA5B JAG1 SLIT3

1.16e-051973247c275a2ac24a9a4f83fceda93a067e754837102f
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OBSL1 THBS2 LRP1B SLIT3

1.16e-051973243bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell5'-Adult-Appendix-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNER THBS1 THBS2 SLIT3

1.16e-05197324b11a5d909942a4299cbc0b27332b1a3f66f3bccd
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OBSL1 THBS2 LRP1B SLIT3

1.16e-051973245b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP2 SEMA5A THBS1 THBS2

1.19e-05198324be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellwk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNER SEMA5A THBS1 THBS2

1.21e-051993248de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCellBronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA5A LYPD1 SEMA5B SLIT3

1.21e-0519932478a9b26215874a46a910a4b93a51fcac1a597618
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A SEMA5B LRP1B SLIT3

1.24e-052003247b845aabfbdfe893acc9334a5707833761bed60b
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A SEMA5B LRP1B SLIT3

1.24e-05200324e3051dcf9b5c8e4dc71a8080b7a7aafea46f2b2b
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A SEMA5B LRP1B SLIT3

1.24e-052003240638273fc0910f47fe7a0b6d9a8639b0e9976d13
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO--|Neuronal / cells hierarchy compared to all cells using T-Statistic

SEMA5A SEMA5B LRP1B SLIT3

1.24e-052003241ce9599cc9d8158e8842ca56f35fa7809c234849
ToppCellControl-Neutrophil|Control / Disease condition and Cell class

MGAM PRDM7 PYGO1

1.00e-04126323450c01d89714feee6529680ec3ce69067a54b37c
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MGAM PRDM7 PYGO1

1.00e-04126323730fc6dc740613b55e40e85334fa30330aa81c3b
ToppCellControl-Neutrophil-|Control / Disease condition and Cell class

MGAM PRDM7 PYGO1

1.00e-0412632365fff5ec2296272e94f44546606587833191dd82
ToppCellControl-Myeloid_G-Neutrophil|Control / Disease group, lineage and cell class

MGAM PRDM7 PYGO1

1.03e-04127323d4af23d621b546785a077c367c3a66c59749fc15
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MGAM PRDM7 PYGO1

1.05e-041283239b3c57d559a5ed8d590dd89b64a57a3227d8c684
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MGAM PRDM7 PYGO1

1.05e-0412832358639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MGAM PRDM7 PYGO1

1.10e-04130323cd6d8d646345b01ff0f04f776330a05b82e63bc9
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VLDLR THBS1 TG

1.43e-04142323a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VLDLR THBS1 TG

1.43e-04142323d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SEMA5A SEMA5B LRP1B

1.85e-0415532377fdae85d36efb776db977eb424b32487ef222e4
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A NTNG2 NOTCH1

1.92e-04157323c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

SEMA5B JAG1 SLIT3

1.96e-041583238d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SEMA5A SEMA5B SLIT3

1.96e-0415832384c0a215dabf697ada036c2b9592d0c61b5077de
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

SEMA5B JAG1 SLIT3

2.03e-04160323fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS2 NTNG2 SLIT3

2.07e-04161323a7e09cf2ca6cd70d40d08440fe9c5ab9befa1b79
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS2 NTNG2 SLIT3

2.07e-0416132308920a716f6ec62538e361211455a30ad726d7be
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP2 TRIM66 PYGO1

2.07e-041613231f4614ae15bd2fc08e555cea4d0152c4a940d048
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

OBSL1 MGAM JAG1

2.07e-041613233e5a125a25d55bf27652f456239b00b315d54d91
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CHRNA9 SEMA5B SLIT3

2.14e-0416332351dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DNER SEMA5A LRP12

2.14e-04163323bba830a302919c8b33f914a8839877fc21dd28a0
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DNER SEMA5A LRP12

2.18e-0416432308819970174a3eb4eee8e1e675075828665b845e
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 SEMA5B NOTCH1

2.18e-04164323f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A JAG1 SLIT3

2.22e-04165323cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A JAG1 SLIT3

2.22e-041653234f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

THBS2 LYPD1 SLIT3

2.26e-041663237c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

THBS2 LYPD1 SLIT3

2.26e-041663237286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 NTNG2 SLIT3

2.30e-04167323805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 NTNG2 SLIT3

2.30e-0416732331cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS2 NTNG2 SLIT3

2.30e-041673233acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

LRP2 LYPD1 SLIT3

2.34e-04168323a086c306be430adf0632ba53e98cd8014d2de330
ToppCelldroplet-Heart-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR LYPD1 NOTCH2

2.38e-041693232e5bb6437bc9c614e337c5ffb6f6457cd9fc7f4c
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMEM201 SEMA5B PYGO1

2.38e-041693232833a8a7094e4d407eb923f2bc59b9b112c6bae4
DrugFlucytosine [2022-85-7]; Up 200; 31uM; MCF7; HT_HG-U133A

LRP2 LRP12 F9 NOTCH2 JAG1

8.26e-062003256450_UP
Drugmonatepil

LRP2 LRP12 LRP1B

8.99e-0629323CID000060810
Drugglycovir

MGAM TG

1.15e-054322CID000060807
Drugvs 261

MGAM TG

1.15e-054322CID000380111
Drugbasic brown 1

DNER TG

1.15e-054322CID000013981
Drugsodium cholate

LRP2 LRP12 THBS1 LRP1B ACOX3 JAG1

1.95e-05408326CID000000303
DrugChr 5

LRP2 VLDLR THBS1 TG

2.76e-05125324CID006448119
Drugbeidellite

DNER MGAM

2.86e-056322CID006367228
DrugPMDETA

MGAM THBS1

2.86e-056322CID000018196
DrugN-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester

NOTCH1 NOTCH2 JAG1

3.21e-0544323ctd:C419410
Drug8-hydroxyquinoline aluminum

DNER MGAM

4.00e-057322CID000090594
Drug17alpha-estradiol

LRP2 VLDLR LRP12 THBS1 IGFALS CHRNA9 LRP1B F9 JAG1

5.42e-051303329CID000000450
Drugtripchlorolide

MGAM JAG1

6.85e-059322CID000159588
Drug25-hydroxycholesterol

LRP2 LRP12 LRP1B NOTCH2

7.24e-05160324CID000065094
Drugprobucol

LRP2 VLDLR LRP12 LRP1B

7.60e-05162324CID000004912
DrugAC1NRBPT

IGFALS F9 JAG1 TG

7.60e-05162324CID005288571
Drug2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine

NOTCH1 JAG1

8.55e-0510322ctd:C028145
Drugiodide

LRP2 VLDLR LRP12 CHRNA9 F9 TG

8.73e-05534326CID000024841
DrugBouin's solution

DNER LRP2 TG

9.01e-0562323CID000124013
Drugflurbiprofen

CHRNA9 F9 NOTCH2 TG

9.37e-05171324CID000003394
Drugnapabucasin

NOTCH1 NOTCH2 JAG1

9.91e-0564323ctd:C000621033
Drugspinel

DNER MGAM

1.04e-0411322CID000159367
DrugWithaferin A [5119-48-2]; Up 200; 1uM; MCF7; HT_HG-U133A

OBSL1 VLDLR LRP12 VEZT

1.05e-041763243902_UP
DrugEpi Lovastatin

LRP2 VLDLR LRP12 THBS1 LRP1B

1.06e-04341325CID000003962
DrugAC1L9K10

MGAM JAG1

1.25e-0412322CID000446726
Drug1,4-dichlorobut-2-ene

DNER MGAM

1.25e-0412322CID000015122
Drugrhamnose

MGAM THBS1 NOTCH2 JAG1 TG

1.29e-04356325CID000000840
DrugWithaferin A [5119-48-2]; Down 200; 1uM; PC3; HT_HG-U133A

THBS1 LYPD1 CHRNA9 VEZT

1.30e-041863243819_DN
Drug2b1g

LRP2 F9 TG

1.35e-0471323CID011963491
Drugcast 3

MGAM THBS1

1.48e-0413322CID000072360
Drugsepiolite

DNER MGAM

1.48e-0413322CID000061797
Drug23 p

DNER MGAM

1.48e-0413322CID006335913
DrugCyproterone acetate [427-51-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

SEMA5A THBS1 VEZT NOTCH1

1.52e-041943244470_DN
DrugNalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A

LRP12 PRDM9 VEZT TG

1.55e-041953242225_UP
DrugFamprofazone [22881-35-2]; Up 200; 10.6uM; HL60; HT_HG-U133A

LRP2 SEMA5A THBS1 VEZT

1.59e-041963242174_UP
DrugAmyleine hydrochloride [532-59-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A

SEMA5A THBS1 THBS2 IGFALS

1.59e-041963244169_UP
DrugCarbimazole [22232-54-8]; Down 200; 21.4uM; HL60; HT_HG-U133A

OBSL1 VEZT NOTCH2 ACOX3

1.59e-041963242437_DN
DrugHydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A

THBS1 CHRNA9 VEZT F9

1.62e-041973242889_UP
Druggentamicin

LRP2 MGAM F9 JAG1

1.65e-04198324CID000003467
DrugNiacin [59-67-6]; Up 200; 32.4uM; PC3; HT_HG-U133A

SEMA5A NOTCH2 ACOX3 TG

1.65e-041983246702_UP
DrugGlimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A

LYPD1 NOTCH2 ACOX3 JAG1

1.65e-041983242809_DN
DrugMepenzolate bromide [76-90-4]; Up 200; 9.6uM; PC3; HT_HG-U133A

LRP2 SEMA5A CHRNA9 SLIT3

1.65e-041983243748_UP
DrugHeptaminol hydrochloride [543-15-7]; Up 200; 22uM; PC3; HT_HG-U133A

VLDLR SEMA5A THBS1 JAG1

1.65e-041983247313_UP
DrugMetronidazole [443-48-1]; Up 200; 23.4uM; PC3; HT_HG-U133A

VLDLR SEMA5A LRP12 CHRNA9

1.68e-041993244023_UP
DrugMethiothepin maleate [19728-88-2]; Up 200; 8.4uM; PC3; HT_HG-U133A

LRP12 THBS1 LYPD1 VEZT

1.68e-041993246312_UP
DrugLidoflazine [3416-26-0]; Down 200; 8.2uM; PC3; HT_HG-U133A

LRP2 SEMA5A VEZT NOTCH1

1.68e-041993245804_DN
DrugTomatidine [77-59-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A

VLDLR LRP12 LYPD1 JAG1

1.71e-042003247166_UP
Drugscopolamine

LRP2 CHRNA9 F9 TG

1.71e-04200324CID000005184
DrugTiCl4

DNER MGAM

1.72e-0414322CID000024193
Druganad

NOTCH2 JAG1

1.99e-0415322CID005287574
Drugepicholesterol

LRP2 VLDLR LRP12 CHRNA9 LRP1B ACOX3

2.26e-04636326CID000000304
Drug5-aza-2'-deoxycytidine

THBS1 IGFALS LRP1B F9 JAG1 SLIT3

2.30e-04638326CID000016886
Drugdiethyl malate

SEMA5A THBS1 THBS2

2.38e-0486323ctd:C058705
Druggemfibrozil

VLDLR F9 ACOX3 TG

2.55e-04222324CID000003463
Drugfagomine

MGAM THBS1

2.57e-0417322CID000072259
DrugLMWH

LRP2 LRP12 THBS1 THBS2 CHRNA9 F9

2.83e-04663326CID000000772
DrugL0074

DNER JAG1

2.89e-0418322CID005360046
Drugsodium ethoxide

ACOX3 TG

2.89e-0418322CID002723922
Drugsiderite

DNER MGAM

2.89e-0418322CID000011248
Drug3,3',4,4',5,5'-hexabromobiphenyl

ACOX3 JAG1

2.89e-0418322CID000104942
DrugTEOS

DNER LYPD1

3.22e-0419322CID000006517
Drug3-hydroxy-3-methylglutaryl-CoA

VLDLR THBS1 F9 ACOX3

3.27e-04237324CID000000084
Drugvitamin E

LRP2 VLDLR LRP12 CHRNA9 LRP1B

3.49e-04441325CID000002116
Drugstearylamine

DNER F9

3.58e-0420322CID000015792
Drugtectochrysin

MGAM TG

3.58e-0420322CID005281954
Drugsilver hydride

MGAM JAG1

3.58e-0420322CID000139654
Drugmangrove

LRP2 LRP12 CHRNA9 LRP1B ACOX3

4.57e-04468325CID000000965
Drugmagnesium oxide

DNER MGAM

4.75e-0423322CID000014792
Drugsterol

LRP2 VLDLR LRP12 ACOX3

4.99e-04265324CID000001107
Drugdestomycin A

MGAM PRDM9 PRDM7

5.18e-04112323CID000003659
Drugmanganese tetroxide

DNER MGAM

5.18e-0424322CID000014825
Drugclioquinol

LRP2 F9 TG

5.45e-04114323CID000002788
Drugpitavastatin

LRP2 LRP12 LRP1B

5.45e-04114323CID005282451
Drugzeolites

DNER MGAM

5.63e-0425322CID006432059
Drug1-piperidinocyclohexanecarbonitrile

NOTCH2 SLIT3

5.63e-0425322CID000062529
Drugphthalocyanine

MGAM LYPD1

5.63e-0425322CID000168374
DrugSi-O

DNER MGAM

5.63e-0425322CID000066241
Drughydrotalcite

DNER MGAM

6.09e-0426322CID000071749
Drugdihydrolipoamide

MGAM NOTCH2 TG

6.18e-04119323CID000000663
DrugAC1Q5HK6

MGAM IGFALS CHRNA9 NOTCH2 TG

6.23e-04501325CID000003640
Drugcoelenterazine

DNER IGFALS

6.57e-0427322CID000002830
DrugAC1Q5PO8

MGAM ACOX3

7.07e-0428322CID000000642
Drugibuprofen

THBS1 F9 NOTCH2 TG

7.37e-04294324CID000003672
Druglithium chromate

MGAM THBS1 F9 TG

7.55e-04296324CID000026627
Drugtetrahydroaldosterone-3-glucuronide

LRP2 LRP12

7.59e-0429322CID000167918
Drugtroglitazone

LRP2 MGAM VLDLR LRP12 LRP1B

7.76e-04526325CID000005591
Drugenzacamene

VLDLR NOTCH2 JAG1

7.82e-04129323ctd:C038939
Drugphosphine;hydrate

DNER MGAM

8.12e-0430322CID000445832
Drug2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

THBS1 THBS2

8.68e-0431322ctd:C577942
DrugAC1NRAS8

SLIT3 TG

9.25e-0432322CID005288068
DrugNIPS

DNER F9

9.25e-0432322CID000196875
DrugSureCN2418015

MGAM THBS2

9.25e-0432322CID009884138
Drugoctylmethoxycinnamate

VLDLR NOTCH2 JAG1

9.70e-04139323ctd:C118580
Drugpropan

DNER MGAM

9.83e-0433322CID000006334
DrugR625

DNER MGAM

9.83e-0433322CID000072375
Drugbiphenylene

THBS1 THBS2

1.04e-0334322CID000009214
DrugZrO2

DNER MGAM

1.11e-0335322CID000062395
DrugIamin

IGFALS TG

1.11e-0335322CID000073587
Drugbenzamidine

LRP2 IGFALS F9

1.14e-03147323CID000002332
Drugezetimibe

LRP2 LRP12 LRP1B

1.14e-03147323CID000150311
DiseaseHepatic ductular hypoplasia

NOTCH2 JAG1

1.14e-062322C2930797
DiseaseAlagille syndrome (is_implicated_in)

NOTCH2 JAG1

1.14e-062322DOID:9245 (is_implicated_in)
DiseaseAlagille Syndrome

NOTCH2 JAG1

1.14e-062322C0085280
DiseaseArteriohepatic dysplasia

NOTCH2 JAG1

1.14e-062322cv:C0085280
DiseaseAlagille Syndrome 2

NOTCH2 JAG1

1.14e-062322C1857761
DiseaseAlagille Syndrome 1

NOTCH2 JAG1

1.14e-062322C1956125
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH2

2.38e-057322DOID:3620 (implicated_via_orthology)
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH2

2.38e-057322DOID:299 (implicated_via_orthology)
Diseaseautoimmune thyroiditis (is_implicated_in)

LRP2 TG

7.47e-0512322DOID:7188 (is_implicated_in)
DiseaseGlioblastoma

NOTCH1 NOTCH2 JAG1

8.66e-0579323C0017636
DiseaseGiant Cell Glioblastoma

NOTCH1 NOTCH2 JAG1

1.04e-0484323C0334588
DiseaseBenign neoplasm of bladder

NOTCH1 NOTCH2

1.19e-0415322C0154017
DiseaseNeoplasm of uncertain or unknown behavior of bladder

NOTCH1 NOTCH2

1.19e-0415322C0496930
DiseaseCarcinoma in situ of bladder

NOTCH1 NOTCH2

1.19e-0415322C0154091
DiseaseMicroangiopathy, Diabetic

THBS1 THBS2

1.35e-0416322C0025945
DiseaseDiabetic Angiopathies

THBS1 THBS2

1.35e-0416322C0011875
DiseaseCarcinoma of bladder

NOTCH1 NOTCH2

1.72e-0418322C0699885
DiseaseGlioblastoma Multiforme

NOTCH1 NOTCH2 JAG1

2.37e-04111323C1621958
DiseaseCarcinoma, Pancreatic Ductal

NOTCH1 JAG1

3.10e-0424322C0887833
Diseasecongenital heart disease (is_implicated_in)

NOTCH1 JAG1

3.10e-0424322DOID:1682 (is_implicated_in)
DiseaseSchizophrenia

LRP2 VLDLR THBS1 NTNG2 JAG1 SLIT3

3.29e-04883326C0036341
DiseaseDwarfism

IGFALS TG

3.37e-0425322C0013336
DiseasePilocytic Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0334583
DiseaseCerebral Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0750935
DiseaseIntracranial Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0750936
DiseaseAstrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0004114
DiseaseJuvenile Pilocytic Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0280783
DiseaseDiffuse Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0280785
DiseaseGrade I Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C1704230
DiseaseSubependymal Giant Cell Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0205768
DiseaseMixed oligoastrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0547065
DiseaseChildhood Cerebral Astrocytoma

NOTCH1 NOTCH2

3.37e-0425322C0338070
Diseasecorpus collosum mid-posterior volume measurement

VLDLR JAG1

3.37e-0425322EFO_0010300
DiseaseGemistocytic astrocytoma

NOTCH1 NOTCH2

3.64e-0426322C0334581
DiseaseProtoplasmic astrocytoma

NOTCH1 NOTCH2

3.64e-0426322C0334580
DiseaseFibrillary Astrocytoma

NOTCH1 NOTCH2

3.64e-0426322C0334582
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH2

3.64e-0426322DOID:1319 (implicated_via_orthology)
DiseaseAnaplastic astrocytoma

NOTCH1 NOTCH2

3.93e-0427322C0334579
Diseasecorpus callosum mid-anterior volume measurement

JAG1 TG

3.93e-0427322EFO_0010297
DiseaseChild Development Disorders, Specific

LRP2 ARFGAP1

4.54e-0429322C0085997
DiseaseChild Development Deviations

LRP2 ARFGAP1

4.54e-0429322C0085996
Diseasecolorectal cancer (implicated_via_orthology)

NOTCH1 NOTCH2

4.86e-0430322DOID:9256 (implicated_via_orthology)
DiseaseDevelopmental Disabilities

LRP2 ARFGAP1

4.86e-0430322C0008073
Diseaseintestinal cancer (implicated_via_orthology)

NOTCH1 NOTCH2

5.54e-0432322DOID:10155 (implicated_via_orthology)
Diseasepack-years measurement, systolic blood pressure

LRP2 LRP1B

6.25e-0434322EFO_0006335, EFO_0006526
Diseasecervical cancer

NOTCH1 NOTCH2

6.25e-0434322C4048328
DiseaseUterine Cervical Neoplasm

NOTCH1 NOTCH2

6.63e-0435322C0007873
DiseaseLymphoma

NOTCH1 NOTCH2

8.66e-0440322C0024299
DiseaseBreast adenocarcinoma

NOTCH1 NOTCH2

9.10e-0441322C0858252
DiseaseDiaphragmatic Hernia

LRP2 SLIT3

9.10e-0441322C0019284
DiseaseNeoplasm of uncertain or unknown behavior of breast

NOTCH1 NOTCH2

9.10e-0441322C0496956

Protein segments in the cluster

PeptideGeneStartEntry
RDDNDPNCTYEGDNN

ACOX3

441

O15254
CEGDDCQPPAYTYNN

IGFALS

566

P35858
QDENNVCFECGAFNP

ARFGAP1

16

Q8N6T3
CQGKNPQEAESYCAQ

CHRNA9

406

Q9UGM1
QAVCENQPLDDICDY

ANO8

226

Q9HCE9
RPEDQGTYCCQAGQD

OBSL1

1871

O75147
GVNCEYEVDECQNQP

NOTCH2

1181

Q04721
YEVDECQNQPCQNGG

NOTCH2

1186

Q04721
GQNCEENIDDCPGNN

NOTCH1

251

P46531
DRCNYQNHCPNGSDE

LRP12

431

Q9Y561
EDNVNPCGDDAYCNQ

LRP1B

3806

Q9NZR2
DCYPDENGDSAENCT

MGAM

1861

O43451
YVDGDQCESNPCLNG

F9

91

P00740
GADENDCQYPTCEQL

LRP2

136

P98164
NDCQDGSDEHACNYP

LRP2

206

P98164
NDCGDNSDENPTYCT

LRP2

2846

P98164
PSGFYQDENCGQQED

PASD1

621

Q8IV76
EPQDDDYLYCEMCQN

PRDM9

196

Q9NQV7
YQCEEFQLNNDCSSP

LYPD1

26

Q8N2G4
CICNEGYEGPNCEQA

DNER

121

Q8NFT8
GAYCETNINDCSQNP

JAG1

661

P78504
CYPNVCDDDQLLCQN

NTNG2

451

Q96CW9
YPCGICTNEVNDDQD

PYGO1

341

Q9Y3Y4
EPQDDDYLYCEMCQN

PRDM7

196

Q9NQW5
ENGPDCAGCNVEYQS

SEMA5A

681

Q13591
SPCDQYECQNGAQCI

SLIT3

1121

O75094
GDRCDNCPYNHNPDQ

THBS1

771

P07996
NCPYNHNPDQADTDN

THBS1

776

P07996
PYQCEECGRAFNDNA

ZNF19

216

P17023
PCVGDAAEYQDCNPQ

SEMA5B

891

Q9P283
DCPHCEQYNGFQENG

TMEM201

66

Q5SNT2
DDGHQNNQDNCPYIS

THBS2

866

P35442
CYQCESEDEPQADGS

VEZT

691

Q9HBM0
EMEYDCENACYNQPG

TRIM66

1021

O15016
QDSGDYAPVQCDVQQ

TG

121

P01266
CPSGYNVEENGRDCQ

VLDLR

736

P98155