Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal anchor activity	SPTBN4 GAS2L1 GAS2L2	5.51e-05	24	62	3	GO:0008093
GeneOntologyBiologicalProcess	protein localization to microtubule end	GAS2L1 GAS2L2	2.58e-05	3	61	2	GO:1905725
GeneOntologyBiologicalProcess	protein localization to microtubule plus-end	GAS2L1 GAS2L2	2.58e-05	3	61	2	GO:1904825
MousePheno	epididymis epithelium degeneration	BMP8B BMP8A	3.17e-05	3	46	2	MP:0004934
Domain	PRP38	PRPF38B PRPF38A	9.48e-06	2	58	2	IPR005037
Domain	PRP38	PRPF38B PRPF38A	9.48e-06	2	58	2	PF03371
Domain	AUTS2	FBRSL1 AUTS2	2.84e-05	3	58	2	IPR023246
Domain	CH	SPTBN4 GAS2L1 MICALL2 GAS2L2	4.92e-05	65	58	4	SM00033
Domain	CH	SPTBN4 GAS2L1 MICALL2 GAS2L2	6.59e-05	70	58	4	PF00307
Domain	-	SPTBN4 GAS2L1 MICALL2 GAS2L2	6.97e-05	71	58	4	1.10.418.10
Domain	CH	SPTBN4 GAS2L1 MICALL2 GAS2L2	7.77e-05	73	58	4	PS50021
Domain	CH-domain	SPTBN4 GAS2L1 MICALL2 GAS2L2	8.63e-05	75	58	4	IPR001715
Domain	NUT	NUTM2B NUTM2A	9.42e-05	5	58	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	9.42e-05	5	58	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	9.42e-05	5	58	2	PF12881
Domain	GAR	GAS2L1 GAS2L2	1.41e-04	6	58	2	PS51460
Domain	-	GAS2L1 GAS2L2	1.41e-04	6	58	2	3.30.920.20
Domain	GAS_dom	GAS2L1 GAS2L2	1.41e-04	6	58	2	IPR003108
Domain	GAS2	GAS2L1 GAS2L2	1.41e-04	6	58	2	PF02187
Domain	GAS2	GAS2L1 GAS2L2	1.41e-04	6	58	2	SM00243
Domain	Inhibin_asu	BMP8B BMP8A	7.23e-04	13	58	2	IPR002405
Domain	TGFb_propeptide	BMP8B BMP8A	3.40e-03	28	58	2	PF00688
Domain	TGF-b_N	BMP8B BMP8A	3.40e-03	28	58	2	IPR001111
Domain	RRM_1	SETD1A SRSF3 RNPS1 SPEN	3.96e-03	208	58	4	PF00076
Domain	TGF-beta-rel	BMP8B BMP8A	4.43e-03	32	58	2	IPR015615
Domain	TGFb_CS	BMP8B BMP8A	4.43e-03	32	58	2	IPR017948
Domain	RRM	SETD1A SRSF3 RNPS1 SPEN	4.61e-03	217	58	4	SM00360
Domain	RRM_dom	SETD1A SRSF3 RNPS1 SPEN	5.40e-03	227	58	4	IPR000504
Domain	RRM	SETD1A SRSF3 RNPS1 SPEN	5.65e-03	230	58	4	PS50102
Domain	TGFB	BMP8B BMP8A	5.89e-03	37	58	2	SM00204
Domain	TGF-b_C	BMP8B BMP8A	5.89e-03	37	58	2	IPR001839
Domain	TGF_BETA_2	BMP8B BMP8A	5.89e-03	37	58	2	PS51362
Domain	TGF_beta	BMP8B BMP8A	5.89e-03	37	58	2	PF00019
Domain	TGF_BETA_1	BMP8B BMP8A	5.89e-03	37	58	2	PS00250
Domain	-	SETD1A SRSF3 RNPS1 SPEN	6.94e-03	244	58	4	3.30.70.330
Domain	SET	SETD1A KMT5C	7.19e-03	41	58	2	PF00856
Domain	SAM_2	SASH1 SFMBT2	7.89e-03	43	58	2	PF07647
Domain	Nucleotide-bd_a/b_plait	SETD1A SRSF3 RNPS1 SPEN	8.42e-03	258	58	4	IPR012677
Domain	SET	SETD1A KMT5C	8.99e-03	46	58	2	SM00317
Pathway	KEGG_SPLICEOSOME	SRSF3 PRPF40B PRPF38B PRPF38A	2.96e-04	127	36	4	M2044
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	SRRM1 SRSF3 RNPS1	5.22e-04	62	36	3	MM15426
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST	BMP8B BMP8A	6.52e-04	15	36	2	M47824
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	SRRM1 SRSF3 RNPS1	6.55e-04	67	36	3	M27694
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY	BMP8B BMP8A	1.17e-03	20	36	2	M47843
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	SRRM1 SRSF3 RNPS1	1.26e-03	84	36	3	M725
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	SRRM1 SRSF3 RNPS1	1.35e-03	86	36	3	MM15413
Pathway	REACTOME_RHOBTB1_GTPASE_CYCLE	SRRM1 SPEN	1.55e-03	23	36	2	M41817
Pathway	REACTOME_MRNA_SPLICING	SRRM1 SRSF3 RNPS1 PRPF38A	1.65e-03	201	36	4	MM15411
Pathway	REACTOME_RHOBTB1_GTPASE_CYCLE	SRRM1 SPEN	1.83e-03	25	36	2	MM15608
Pathway	REACTOME_MRNA_SPLICING	SRRM1 SRSF3 RNPS1 PRPF38A	2.01e-03	212	36	4	M14033
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SPTBN4 SRRM1 SRSF3 GSE1 PRRC2C PRPF38B PRPF38A SPEN SFMBT2	2.43e-08	361	65	9	26167880
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	BMP8B RGS20 SASH1 CENPA PRICKLE3 SCARF2 SPEN KIFC2	1.86e-07	329	65	8	17474147
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GAS2L1 SETD1A BMP8B PWWP2B MYO9B KMT5C ZNF335 FBRSL1 TP53I13 MARVELD3 SPEN KIFC2	8.50e-07	1105	65	12	35748872
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	3.44e-06	2	65	2	31940275
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	3.44e-06	2	65	2	21277400
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	3.44e-06	2	65	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	3.44e-06	2	65	2	8682296
Pubmed	Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules.	GAS2L1 GAS2L2	3.44e-06	2	65	2	12584248
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SRRM1 PWWP2B GSE1 TTC28 PRPF40B RNPS1 SUDS3 FBRSL1 QSOX2 FBXL6 GJD4	6.47e-06	1116	65	11	31753913
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	1.03e-05	3	65	2	22456610
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	1.03e-05	3	65	2	9076678
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	1.03e-05	3	65	2	10894154
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	1.03e-05	3	65	2	12925636
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	1.03e-05	3	65	2	22579288
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP8B BMP8A	1.03e-05	3	65	2	11784057
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	1.03e-05	3	65	2	25451979
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SRRM1 PWWP2B GSE1 PRICKLE3 RNPS1 ZNF335 PRPF38B PRPF38A SPEN	1.34e-05	774	65	9	15302935
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	GSE1 TTC28 NFATC2IP MYO9B PRRC2C FBRSL1 ZCCHC2 SPEN	1.38e-05	588	65	8	38580884
Pubmed	GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.	GAS2L1 GAS2L2	2.06e-05	4	65	2	24706950
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	2.06e-05	4	65	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	2.06e-05	4	65	2	8843393
Pubmed	Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions.	SRRM1 SRSF3	2.06e-05	4	65	2	10809668
Pubmed	An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.	SRRM1 RNPS1	3.43e-05	5	65	2	12944400
Pubmed	The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.	SRRM1 RNPS1	3.43e-05	5	65	2	11118221
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SPTBN4 FBRSL1 SFMBT2 WNK3	3.96e-05	101	65	4	10997877
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SETD1A SRSF3 GSE1 SUDS3 SPEN FBXL6	4.32e-05	341	65	6	32971831
Pubmed	Interaction network of human early embryonic transcription factors.	SETD1A GSE1 SUDS3 FBRSL1 AUTS2 SPEN	5.07e-05	351	65	6	38297188
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	BMP8B BMP8A	5.13e-05	6	65	2	9878243
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP8B BMP8A	5.13e-05	6	65	2	7605753
Pubmed	The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.	SRSF3 RNPS1	5.13e-05	6	65	2	8617202
Pubmed	The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.	BMP8B BMP8A	7.18e-05	7	65	2	9070944
Pubmed	Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.	BMP8B BMP8A	7.18e-05	7	65	2	12107726
Pubmed	The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction.	SRRM1 RNPS1	9.56e-05	8	65	2	9933612
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1A PRRC2C PRPF38B PRPF38A SPEN	1.09e-04	251	65	5	31076518
Pubmed	Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.	BMP8B BMP8A	1.23e-04	9	65	2	15028287
Pubmed	The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.	SRRM1 RNPS1	1.23e-04	9	65	2	12093754
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	BMP8B BMP8A	1.23e-04	9	65	2	1460021
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SRRM1 SRSF3 RNPS1 PRRC2C FBRSL1 CHD2 PRPF38A SPEN	1.28e-04	807	65	8	22681889
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	SRRM1 SRSF3 AEBP1 RNPS1 PRPF38B	1.51e-04	269	65	5	29511261
Pubmed	Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.	SRRM1 RNPS1	1.53e-04	10	65	2	11546874
Pubmed	Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.	BMP8B BMP8A	1.87e-04	11	65	2	10721728
Pubmed	SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.	SRRM1 SRSF3	1.87e-04	11	65	2	9472028
Pubmed	Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.	SRSF3 AUTS2 PRPF38B	1.98e-04	60	65	3	29055695
Pubmed	Bmp7 regulates germ cell proliferation in mouse fetal gonads.	BMP8B BMP8A	2.65e-04	13	65	2	18391523
Pubmed	Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.	AUTS2 PAX1	2.65e-04	13	65	2	22693459
Pubmed	New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.	BMP8B BMP8A	3.08e-04	14	65	2	11526197
Pubmed	Global comparative transcriptome analysis of cartilage formation in vivo.	BMP8B BMP8A	4.06e-04	16	65	2	19272164
Pubmed	Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance.	EVA1B SCARF2	4.06e-04	16	65	2	27546376
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	SRRM1 SRSF3 RNPS1 PRRC2C PRPF38B PRPF38A SPEN	4.26e-04	731	65	7	29298432
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	GSE1 RNPS1 FBRSL1 PRPF38A SPEN	4.37e-04	339	65	5	30415952
Pubmed	Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.	BMP8B BMP8A	4.59e-04	17	65	2	14736746
Pubmed	Dysfunction of programmed embryo senescence is linked to genetic developmental defects.	BMP8B BMP8A	5.16e-04	18	65	2	37017267
Pubmed	Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.	CACNA1D SRRM3	5.16e-04	18	65	2	33087486
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	AUTS2 CHD2	5.16e-04	18	65	2	30111840
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	MYO9B ADAMTS17 PAPPA QSOX2	5.26e-04	198	65	4	20881960
Pubmed	Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.	SETD1A SUDS3	7.06e-04	21	65	2	12670868
Pubmed	Immunomic analysis of human sarcoma.	AUTS2 PRPF38B	7.06e-04	21	65	2	12601173
Pubmed	CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.	SRRM1 RNPS1 PRPF38A	7.40e-04	94	65	3	37468549
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SRRM1 SETD1A SRSF3 GSE1 RNPS1 KMT5C PRPF38B CHD2 PRPF38A	7.43e-04	1318	65	9	30463901
Pubmed	Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations.	SRRM1 SRSF3 RNPS1	7.86e-04	96	65	3	25948554
Pubmed	A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.	AUTS2 PAPPA	8.48e-04	23	65	2	35065713
Pubmed	UPF2 is a critical regulator of liver development, function and regeneration.	SRRM1 SRSF3	9.24e-04	24	65	2	20657840
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	GSE1 FBRSL1	9.24e-04	24	65	2	33722704
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TTC28 PRRC2C IGSF9B	9.92e-04	104	65	3	10470851
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	SRRM1 RNPS1 PRPF38B	9.92e-04	104	65	3	31365120
Pubmed	ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.	SRRM1 SRSF3 RNPS1	1.08e-03	107	65	3	20508642
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	SRRM1 SRSF3 RNPS1	1.14e-03	109	65	3	12226669
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	PWWP2B SUDS3 ZNF335	1.17e-03	110	65	3	26841866
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SRRM1 RNPS1 SPEN	1.29e-03	114	65	3	31553912
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	SRRM1 SRSF3 RNPS1	1.32e-03	115	65	3	17332742
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	SRRM1 SRSF3 RNPS1 PRPF38B	1.35e-03	255	65	4	15324660
Pubmed	Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.	CACNA1D SHISA6	1.35e-03	29	65	2	23396134
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SRRM1 SRSF3 GSE1 RNPS1 SUDS3 PRRC2C	1.40e-03	655	65	6	35819319
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	GSE1 SPEN	1.45e-03	30	65	2	26593974
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	SRRM1 SRSF3 GSE1 RNPS1 PRRC2C SPEN	1.52e-03	665	65	6	30457570
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	GSE1 NFATC2IP RNPS1 SUDS3	1.61e-03	268	65	4	33640491
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	SRSF3 GSE1 PRPF40B PRRC2C AUTS2	1.66e-03	457	65	5	32344865
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	SRRM1 SETD1A PRICKLE3 RNPS1	1.66e-03	270	65	4	24366813
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SRRM1 GSE1 CENPA PRICKLE3 RNPS1 NUTM2D FBXL6	1.68e-03	925	65	7	28986522
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SPTBN4 PWWP2B SRSF3 FBRSL1 AUTS2 PRPF38B CHD2 IGSF9B SFMBT2	1.74e-03	1489	65	9	28611215
Pubmed	Forkhead box a2 (FOXA2) is essential for uterine function and fertility.	BMP8B BMP8A	1.75e-03	33	65	2	28049832
Pubmed	Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.	BMP8B BMP8A	1.75e-03	33	65	2	32640236
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SETD1A TTC28 PRRC2C CHD2 SPEN	1.86e-03	469	65	5	27634302
Pubmed	Genome-wide association study of smoking behaviours among Bangladeshi adults.	SASH1 USP51	1.86e-03	34	65	2	24665060
Interaction	CLK1 interactions	SPTBN4 SRRM1 SRSF3 RNPS1 PRPF38A SPEN SFMBT2	4.31e-06	219	61	7	int:CLK1
Interaction	TSR3 interactions	GAS2L2 PRICKLE3 RNPS1 FBXL6	1.23e-05	47	61	4	int:TSR3
Interaction	RBM25 interactions	SRRM1 SRSF3 PRPF40B RNPS1 PRPF38A SPEN FBXL6	5.29e-05	323	61	7	int:RBM25
Interaction	SRPK2 interactions	SRRM1 SRSF3 GSE1 RNPS1 PRRC2C PRPF38B CHD2 PRPF38A SPEN FBXL6	5.33e-05	717	61	10	int:SRPK2
Cytoband	10q23.2	NUTM2A NUTM2D	2.81e-04	17	67	2	10q23.2
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	2.10e-04	11	36	2	455
GeneFamily	RNA binding motif containing	SETD1A SRSF3 RNPS1 SPEN	8.21e-04	213	36	4	725
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1A KMT5C	2.08e-03	34	36	2	487
GeneFamily	LIM domain containing	MICALL2 PRICKLE3	6.14e-03	59	36	2	1218
GeneFamily	Sterile alpha motif domain containing	SASH1 SFMBT2	1.33e-02	88	36	2	760
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_1000	SRRM1 SETD1A SRSF3 PRRC2C PRPF38B CHD2	7.93e-05	249	61	6	gudmap_developingGonad_P2_epididymis_1000_k3
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000	SRRM1 SETD1A SRSF3 PRRC2C PRPF38B CHD2	9.84e-05	259	61	6	gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_500	SRRM1 SETD1A SRSF3 PRRC2C CHD2	1.02e-04	162	61	5	gudmap_developingGonad_e16.5_epididymis_500_k2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SASH1 AUTS2 PAPPA SFMBT2 SHISA6	8.35e-06	189	65	5	06c44746fa4f02e6e2b3b635cdf2d8dfef3754d3
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D TTC28 AEBP1 ADAMTS17 PAPPA	9.01e-06	192	65	5	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1D TTC28 AEBP1 AUTS2 PAPPA	9.24e-06	193	65	5	e6b75be08e33c1de079fb5c02f0b4468128b369c
Disease	Ovarian cyst	TTC28 IFNL4	4.47e-05	5	63	2	HP_0000138
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	4.47e-05	5	63	2	C0206630
Disease	PROSTATE CANCER, HEREDITARY, 1	TTC28 MYO9B FBRSL1	2.91e-04	60	63	3	C4722327
Disease	Prostate cancer, familial	TTC28 MYO9B FBRSL1	4.40e-04	69	63	3	C2931456
Disease	mortality	TTC28 AUTS2 PAPPA SFMBT2	5.19e-04	173	63	4	EFO_0004352
Disease	pulse pressure measurement	SPTBN4 CACNA1D TTC28 PRPF40B SYNPO2L FBRSL1 CHD2 MARVELD3 ZCCHC2 QSOX2	6.90e-04	1392	63	10	EFO_0005763
Disease	cognitive function measurement	CACNA1D TTC28 NFATC2IP PRPF40B PRRC2C ZNF335 AUTS2 CHD2 IGSF9B ZCCHC2	8.66e-04	1434	63	10	EFO_0008354
Disease	diabetes mellitus (implicated_via_orthology)	BMP8B BMP8A	1.41e-03	26	63	2	DOID:9351 (implicated_via_orthology)
Disease	mean platelet volume	SRRM1 SRSF3 GSE1 TTC28 PRICKLE3 MYO9B FBRSL1 SRRM3	1.43e-03	1020	63	8	EFO_0004584
Disease	Epilepsy	SETD1A AUTS2 CHD2	1.66e-03	109	63	3	C0014544
Disease	resting heart rate, chronic obstructive pulmonary disease	SYNPO2L BMP8A	1.88e-03	30	63	2	EFO_0000341, EFO_0004351
Disease	Antihypertensive use measurement	CACNA1D SRRM1 MYO9B AUTS2	2.50e-03	265	63	4	EFO_0009927
Disease	SAPHO syndrome	IGSF9B C2CD4C	2.55e-03	35	63	2	EFO_1001164
Disease	mean arterial pressure	CACNA1D NOX5 MYO9B SYNPO2L AUTS2	4.26e-03	499	63	5	EFO_0006340
Disease	autism	MYO9B FBXL6	4.75e-03	48	63	2	EFO_0003758
Disease	serum IgG glycosylation measurement	ADAMTS17 AUTS2 CHD2 MOBP SHISA6	5.19e-03	523	63	5	EFO_0005193
Disease	monoclonal gammopathy	AUTS2 SFMBT2	5.76e-03	53	63	2	EFO_0000203
Disease	urinary albumin to creatinine ratio	RGS20 PRRC2C AUTS2	6.68e-03	179	63	3	EFO_0007778
Disease	forced expiratory volume	CACNA1D SETD1A SCARF2 ADAMTS17 BMP8A QSOX2	6.69e-03	789	63	6	EFO_0004314

Protein segments in the cluster

Peptide	Gene	Start	Entry
PARREPRAVPRATPR	FAM246A	161	A0A494C0Y3
PARREPRAVPRAAPR	FAM246B	161	A0A494C0N9
PRTARPPRRRRRESS	FBRSL1	61	Q9HCM7
RRQKQPRPPPSRRRR	AEBP1	251	Q8IUX7
RKRRRMLRERSPSPP	GSE1	816	Q14687
VPRSRRRPRPRPRAS	AHI1-DT	131	P0C7V0
RRASRRTPRQPPRGP	FBXL6	61	Q8N531
SRRRLTRRAPPEPGP	C2CD4C	276	Q8TF44
LRRPRRRRRPPCAPG	EFCC1	176	Q9HA90
RRRRPRTPPAAPRAR	ADAMTS17	61	Q8TE56
PSRRVKRSRRRPLLP	TP53I13	366	Q8NBR0
RARRSPPPRAARLPR	QSOX2	21	Q6ZRP7
APRPRPRRPRQLTRA	NOX5	216	Q96PH1
PQPRVRPRKRRRPRP	KMT5C	326	Q86Y97
RPRKRRRPRPRRAPV	KMT5C	331	Q86Y97
RRRMRRRPGPPTSPS	GJD4	221	Q96KN9
RRVPRPRPRSGSRPR	CCDC194	196	A0A1B0GVG4
ARSPSPPRRRRLAVP	MICALL2	656	Q8IY33
MSSRSPRPPPRRSRR	KCNK12	1	Q9HB15
PRRTRPPKRRPNHRR	C19orf85	36	A0A1B0GUS0
APSRPRPPRRKRRES	AUTS2	66	Q8WXX7
RRARRDPRAGRPPRP	PAPPA	26	Q13219
QRRRPRSPPPRAPSR	PRICKLE3	496	O43900
PRPPRGSSPRTRARR	PAX1	451	P15863
RPRPRGPAQRRDPRS	EVA1B	56	Q9NVM1
MGPRRRSRKPEAPRR	CENPA	1	P49450
RSRKPEAPRRRSPSP	CENPA	6	P49450
KARRPVPRRTVPKPR	CHD2	176	O14647
DRKPSRIPTPRGPRR	GAS2L1	641	Q99501
RRLRPPTPSSPRPRR	GAS2L2	331	Q8NHY3
PSPIRTPRAVRPLRR	BMP8A	256	Q7Z5Y6
PRRDPPRPSSCARLR	IFNL4	66	K9M1U5
RARPRERDPGRRPHP	MARVELD3	11	Q96A59
PSPIRTPRAVRPLRR	BMP8B	256	P34820
PQPPPRTIKRTRRRL	PWWP2B	141	Q6NUJ5
DSRRSPRRRLLPPTP	CACNA1D	1901	Q01668
RKPRGRRRPDLPAPE	KIFC2	36	Q96AC6
PPAPLARRSPRGRRI	KIFC2	726	Q96AC6
TKARRPPPRPHRRAE	NUTM2A	476	Q8IVF1
TKARRPPPRPHRRAE	NUTM2B	476	A6NNL0
ARRPPPRPHRRAETK	NUTM2D	406	Q5VT03
QEKPRRPRRRGPTRP	SYNPO2L	151	Q9H987
SAPRRRGRRRPRPAP	SRRM3	401	A6NNA2
SPRRRSPVRRRSRSP	RNPS1	276	Q15287
RRPRSPPEPLRVRAR	TMEM200B	31	Q69YZ2
RRPPPEAPRRRLDFS	RGS20	91	O76081
ARERPRRQRPTRPPR	PRRC2C	1416	Q9Y520
TRPPRQDKPPRFRRL	PRRC2C	1426	Q9Y520
QKPLPRERPRRPIRA	SHISA6	351	Q6ZSJ9
PRSERQPRSPPRSER	MOBP	101	Q13875
PRSERQPRSPPRSER	MOBP	111	Q13875
PRSERQPRSPPRSER	MOBP	121	Q13875
PAGSPPRSPRRLLRR	PROSER3	456	Q2NL68
DRRPAGPPREPVRRR	NFATC2IP	96	Q8NCF5
RRSLRSHARRRRPPP	SETD1A	1391	O15047
AKAPSRRRRDCRPPP	ZCCHC2	31	Q9C0B9
AVPSRKRRRGRRPPA	nan	11	P0C880
RRKPRPRPQPRARSR	USP51	101	Q70EK9
TTPRRGRPPKTRRRA	SPEN	1946	Q96T58
RRSPPPRRRSPRRRS	SRSF3	106	P84103
RPRPSPRQARRAEPS	IGSF9B	1176	Q9UPX0
SPRRRKSRSPSPRRR	SRRM1	171	Q8IYB3
PRRRPSPRRRPSPRR	SRRM1	311	Q8IYB3
SPRRRPSPRRRTPPR	SRRM1	316	Q8IYB3
RRRSPSPPPTRRRRS	SRRM1	546	Q8IYB3
RRRRSPSPAPPPRRR	SRRM1	556	Q8IYB3
ACRGKDPTRRPRPRR	SCARF2	466	Q96GP6
RSPRRSLSPRRSPRR	PRPF38B	261	Q5VTL8
GSEPVRRPPPERTRR	SFMBT2	766	Q5VUG0
KRPTRRRRKGRPPQP	SASH1	621	O94885
ELPERTPRPDRPRAR	SPTBN4	2361	Q9H254
TPRPDRPRARDRPKP	SPTBN4	2366	Q9H254
RPRARDRPKPRRRPR	SPTBN4	2371	Q9H254
PSLRPPKRRRRNPSE	PRPF40B	726	Q6NWY9
RRSRSPKRRSPSPRR	PRPF38A	241	Q8NAV1
PKRRSPSPRRERHRS	PRPF38A	246	Q8NAV1
PSPRRERHRSKSPRR	PRPF38A	251	Q8NAV1
TPARSRRRREPESPP	TTC28	16	Q96AY4
RRRPNDPVPIPDKRR	SUDS3	186	Q9H7L9
RLQRPTPSTPRPRRR	ZNF335	336	Q9H4Z2
PRRPRSFKSKLRSRP	WNK3	1586	Q9BYP7
AAPVRRREPPARRPD	MYO9B	2091	Q13459