Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA2 CHRNA3 CHRNB3	3.91e-06	17	37	3	GO:0022848
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRNA2 CHRNA3 CHRNB3	1.01e-05	23	37	3	GO:0015464
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	CHRNA2 CHRNA3 CHRNB3	6.87e-05	43	37	3	GO:0005231
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRNA2 CHRNA3 CHRNB3	1.60e-04	57	37	3	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	CHRNA2 CHRNA3 CHRNB3	1.86e-04	60	37	3	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	CHRNA2 CHRNA3 CHRNB3	2.36e-04	65	37	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	CHRNA2 CHRNA3 CHRNB3	2.36e-04	65	37	3	GO:0022824
GeneOntologyMolecularFunction	acetylcholine binding	CHRNA3 CHRNB3	2.57e-04	13	37	2	GO:0042166
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRNA2 CHRNA3 CHRNB3	3.61e-04	75	37	3	GO:0098960
GeneOntologyMolecularFunction	G protein-coupled receptor binding	FZD1 NUP85 HOMER3 YARS1 STAT3	3.72e-04	337	37	5	GO:0001664
GeneOntologyMolecularFunction	channel activity	SLC12A6 CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	3.73e-04	525	37	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC12A6 CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	3.77e-04	526	37	6	GO:0022803
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	CHRNA2 CHRNA3 CHRNB3	3.90e-04	77	37	3	GO:0005230
GeneOntologyMolecularFunction	monoatomic cation channel activity	CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	4.03e-04	343	37	5	GO:0005261
GeneOntologyMolecularFunction	Wnt receptor activity	FZD1 FZD10	4.46e-04	17	37	2	GO:0042813
GeneOntologyMolecularFunction	chemokine receptor binding	NUP85 YARS1 STAT3	4.52e-04	81	37	3	GO:0042379
GeneOntologyMolecularFunction	neurotransmitter receptor activity	CHRNA2 CHRNA3 CHRNB3	8.37e-04	100	37	3	GO:0030594
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC12A6 CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	1.28e-03	664	37	6	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion channel activity	CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	1.49e-03	459	37	5	GO:0005216
GeneOntologyMolecularFunction	Wnt-protein binding	FZD1 FZD10	1.81e-03	34	37	2	GO:0017147
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	CHRNA2 CHRNA3 CHRNB3	2.20e-03	140	37	3	GO:0099094
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC12A6 CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	3.12e-03	793	37	6	GO:0015075
GeneOntologyMolecularFunction	gated channel activity	CHRNA2 CHRNA3 CHRNB3 CACNA2D3	3.29e-03	334	37	4	GO:0022836
GeneOntologyMolecularFunction	CCR chemokine receptor binding	NUP85 STAT3	4.83e-03	56	37	2	GO:0048020
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CHRNA2 CHRNA3 CHRNB3	5.42e-03	193	37	3	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	CHRNA2 CHRNA3 CHRNB3	5.74e-03	197	37	3	GO:0022834
GeneOntologyBiologicalProcess	postsynaptic signal transduction	CHRNA2 CHRNA3 STAT3 CHRNB3	7.77e-06	69	38	4	GO:0098926
GeneOntologyBiologicalProcess	membrane depolarization	CHRNA2 CHRNA3 CHRNB3 SCN8A	7.13e-05	121	38	4	GO:0051899
GeneOntologyBiologicalProcess	synaptic transmission, cholinergic	CHRNA2 CHRNA3 CHRNB3	7.25e-05	44	38	3	GO:0007271
GeneOntologyBiologicalProcess	acetylcholine receptor signaling pathway	CHRNA2 CHRNA3 CHRNB3	1.13e-04	51	38	3	GO:0095500
GeneOntologyBiologicalProcess	cellular response to acetylcholine	CHRNA2 CHRNA3 CHRNB3	1.27e-04	53	38	3	GO:1905145
GeneOntologyBiologicalProcess	response to acetylcholine	CHRNA2 CHRNA3 CHRNB3	1.49e-04	56	38	3	GO:1905144
GeneOntologyBiologicalProcess	response to nicotine	CHRNA2 CHRNA3 CHRNB3	1.66e-04	58	38	3	GO:0035094
GeneOntologyBiologicalProcess	regulation of skeletal muscle satellite cell proliferation	PAXBP1 STAT3	2.55e-04	13	38	2	GO:0014842
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRNA2 CHRNA3 CHRNB3	4.44e-06	18	38	3	GO:0005892
GeneOntologyCellularComponent	monoatomic ion channel complex	CHRNA2 CHRNA3 CHRNB3 CACNA2D3 SCN8A	5.78e-04	378	38	5	GO:0034702
GeneOntologyCellularComponent	dopaminergic synapse	CHRNA3 CHRNB3	7.26e-04	22	38	2	GO:0098691
Domain	Nicotinic_acetylcholine_rcpt	CHRNA2 CHRNA3 CHRNB3	3.94e-06	16	37	3	IPR002394
Domain	Acetylcholine_rcpt_TM	CHRNA2 CHRNA3 CHRNB3	1.23e-05	23	37	3	IPR027361
Domain	-	CHRNA2 CHRNA3 CHRNB3	1.23e-05	23	37	3	1.20.120.370
Domain	Neurotransmitter_ion_chnl_CS	CHRNA2 CHRNA3 CHRNB3	9.59e-05	45	37	3	IPR018000
Domain	Neur_chan_memb	CHRNA2 CHRNA3 CHRNB3	1.02e-04	46	37	3	PF02932
Domain	Neur_chan_LBD	CHRNA2 CHRNA3 CHRNB3	1.09e-04	47	37	3	PF02931
Domain	Neur_channel	CHRNA2 CHRNA3 CHRNB3	1.09e-04	47	37	3	IPR006201
Domain	Neur_chan_lig-bd	CHRNA2 CHRNA3 CHRNB3	1.09e-04	47	37	3	IPR006202
Domain	NEUROTR_ION_CHANNEL	CHRNA2 CHRNA3 CHRNB3	1.09e-04	47	37	3	PS00236
Domain	Neurotrans-gated_channel_TM	CHRNA2 CHRNA3 CHRNB3	1.09e-04	47	37	3	IPR006029
Domain	-	CHRNA2 CHRNA3 CHRNB3	1.09e-04	47	37	3	2.70.170.10
Domain	Frizzled	FZD1 FZD10	2.08e-04	11	37	2	IPR000539
Domain	Frizzled	FZD1 FZD10	2.08e-04	11	37	2	PF01534
Domain	Frizzled	FZD1 FZD10	2.08e-04	11	37	2	SM01330
Domain	TIL	MUC19 BMPER	2.49e-04	12	37	2	PF01826
Domain	C8	MUC19 BMPER	2.49e-04	12	37	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC19 BMPER	2.94e-04	13	37	2	IPR014853
Domain	C8	MUC19 BMPER	2.94e-04	13	37	2	SM00832
Domain	TIL_dom	MUC19 BMPER	3.42e-04	14	37	2	IPR002919
Domain	VWFD	MUC19 BMPER	4.50e-04	16	37	2	PS51233
Domain	VWD	MUC19 BMPER	4.50e-04	16	37	2	SM00216
Domain	VWF_type-D	MUC19 BMPER	4.50e-04	16	37	2	IPR001846
Domain	VWD	MUC19 BMPER	4.50e-04	16	37	2	PF00094
Domain	Frizzled/SFRP	FZD1 FZD10	4.50e-04	16	37	2	IPR015526
Domain	CTCK_1	MUC19 CCN6	5.73e-04	18	37	2	PS01185
Domain	FRI	FZD1 FZD10	7.09e-04	20	37	2	SM00063
Domain	-	FZD1 FZD10	7.83e-04	21	37	2	1.10.2000.10
Domain	CT	MUC19 CCN6	8.60e-04	22	37	2	SM00041
Domain	Frizzled_dom	FZD1 FZD10	1.03e-03	24	37	2	IPR020067
Domain	FZ	FZD1 FZD10	1.03e-03	24	37	2	PS50038
Domain	Fz	FZD1 FZD10	1.03e-03	24	37	2	PF01392
Domain	Cys_knot_C	MUC19 CCN6	1.11e-03	25	37	2	IPR006207
Domain	CTCK_2	MUC19 CCN6	1.11e-03	25	37	2	PS01225
Domain	VWC	MUC19 BMPER	2.57e-03	38	37	2	SM00214
Domain	VWFC_2	MUC19 BMPER	2.57e-03	38	37	2	PS50184
Domain	VWF_dom	MUC19 BMPER	3.13e-03	42	37	2	IPR001007
Domain	GPCR_2-like	FZD1 FZD10	6.29e-03	60	37	2	IPR017981
Domain	GPCR_2_secretin-like	FZD1 FZD10	6.29e-03	60	37	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	FZD1 FZD10	6.49e-03	61	37	2	PS50261
Domain	TSP_1	CCN6 ADAMTS7	6.91e-03	63	37	2	PF00090
Domain	TSP1	CCN6 ADAMTS7	7.34e-03	65	37	2	SM00209
Domain	TSP1_rpt	CCN6 ADAMTS7	7.34e-03	65	37	2	IPR000884
Domain	TSP1	CCN6 ADAMTS7	7.34e-03	65	37	2	PS50092
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA3 CHRNB3	5.85e-07	9	28	3	M27597
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA3 CHRNB3	5.85e-07	9	28	3	MM15313
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA3 CHRNB3	1.15e-06	11	28	3	M883
Pathway	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA3 CHRNB3	1.53e-06	12	28	3	M48008
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA3 CHRNB3	1.53e-06	12	28	3	MM15312
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA2 CHRNA3 CHRNB3	2.52e-06	14	28	3	M757
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA2 CHRNA3 CHRNB3	3.14e-06	15	28	3	MM14704
Pathway	REACTOME_INTERLEUKIN_35_SIGNALLING	IL12RB2 STAT3	1.36e-04	9	28	2	MM15580
Pathway	KEGG_MEDICUS_REFERENCE_IL12_23_TO_JAK_STAT_SIGNALING_PATHWAY	IL12RB2 STAT3	1.70e-04	10	28	2	M47907
Pathway	REACTOME_INTERLEUKIN_35_SIGNALLING	IL12RB2 STAT3	2.48e-04	12	28	2	M27860
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	FZD1 FZD10	3.41e-04	14	28	2	M47834
Pathway	REACTOME_INTERLEUKIN_12_FAMILY_SIGNALING	IL12RB2 STAT3	4.49e-04	16	28	2	MM15127
Pathway	KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY	FZD1 FZD10	4.49e-04	16	28	2	M47823
Pathway	REACTOME_NEURONAL_SYSTEM	HOMER3 CHRNA2 CHRNA3 CHRNB3 CACNA2D3	4.61e-04	335	28	5	MM14503
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO	FZD1 FZD10	6.37e-04	19	28	2	M47833
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	CHRNA2 CHRNA3 CHRNB3 CACNA2D3	7.53e-04	211	28	4	MM14502
Pathway	REACTOME_NEURONAL_SYSTEM	HOMER3 CHRNA2 CHRNA3 CHRNB3 CACNA2D3	1.16e-03	411	28	5	M735
Pathway	PID_IL27_PATHWAY	IL12RB2 STAT3	1.20e-03	26	28	2	M36
Pathway	PID_WNT_SIGNALING_PATHWAY	FZD1 FZD10	1.39e-03	28	28	2	M77
Pubmed	Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.	CHRNA2 CHRNA3 CHRNB3	4.20e-08	7	38	3	1505988
Pubmed	Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.	CHRNA2 CHRNA3 CHRNB3	1.01e-07	9	38	3	8906617
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRNA2 CHRNA3 CHRNB3	1.44e-07	10	38	3	10336173
Pubmed	Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.	CHRNA2 CHRNA3 CHRNB3	1.44e-07	10	38	3	20736995
Pubmed	Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.	CHRNA2 CHRNA3 CHRNB3	1.97e-07	11	38	3	12225896
Pubmed	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	CHRNA2 CHRNA3 CHRNB3	2.63e-07	12	38	3	20584212
Pubmed	Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.	CHRNA2 CHRNA3 CHRNB3	4.34e-07	14	38	3	19059502
Pubmed	Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.	CHRNA2 CHRNA3 CHRNB3	5.43e-07	15	38	3	8838678
Pubmed	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.	CHRNA2 CHRNA3 CHRNB3	6.67e-07	16	38	3	19259974
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRNA2 CHRNA3 CHRNB3	1.15e-06	19	38	3	17373692
Pubmed	A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor.	CHRNA3 CHRNB3	1.16e-06	2	38	2	9624109
Pubmed	Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.	CHRNA3 CHRNB3	1.16e-06	2	38	2	24057674
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	PHF2 PAXBP1 CHERP STAG1	2.19e-06	84	38	4	26299517
Pubmed	The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors.	CHRNA3 CHRNB3	3.48e-06	3	38	2	12912995
Pubmed	Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.	CHRNA2 CHRNB3	3.48e-06	3	38	2	23943838
Pubmed	Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes.	CHRNA3 CHRNB3	3.48e-06	3	38	2	11118490
Pubmed	Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate.	CHRNA2 CHRNA3	6.96e-06	4	38	2	29688589
Pubmed	Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.	CHRNA3 CHRNB3	6.96e-06	4	38	2	20840187
Pubmed	IL-6/Stat3 suppresses osteogenic differentiation in ossification of the posterior longitudinal ligament via miR-135b-mediated BMPER reduction.	BMPER STAT3	6.96e-06	4	38	2	36305971
Pubmed	Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.	CHRNA3 CHRNB3	1.16e-05	5	38	2	20418888
Pubmed	Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.	CHRNA3 CHRNB3	1.16e-05	5	38	2	25031416
Pubmed	Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.	CHRNA2 CHRNB3	1.16e-05	5	38	2	9193799
Pubmed	Nicotinic acetylcholine receptors: from structure to brain function.	CHRNA2 CHRNB3	1.16e-05	5	38	2	12783266
Pubmed	Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions.	CHRNA2 CHRNA3	1.74e-05	6	38	2	10095079
Pubmed	Myocilin is a modulator of Wnt signaling.	FZD1 FZD10	2.43e-05	7	38	2	19188438
Pubmed	Interleukin-35 induces regulatory B cells that suppress autoimmune disease.	IL12RB2 STAT3	2.43e-05	7	38	2	24743305
Pubmed	Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.	CHRNA3 CHRNB3	2.43e-05	7	38	2	9009220
Pubmed	Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.	CHRNA2 CHRNB3	2.43e-05	7	38	2	20231857
Pubmed	Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.	FZD1 FZD10	2.43e-05	7	38	2	15923619
Pubmed	Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.	CHRNA2 CHRNB3	3.24e-05	8	38	2	17559419
Pubmed	Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.	ARID2 SUPT16H	3.24e-05	8	38	2	20599239
Pubmed	Sources of energy for gating by neurotransmitters in acetylcholine receptor channels.	CHRNA2 CHRNA3	4.16e-05	9	38	2	22647603
Pubmed	The composition and signaling of the IL-35 receptor are unconventional.	IL12RB2 STAT3	4.16e-05	9	38	2	22306691
Pubmed	Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.	CHRNA2 CHRNB3	4.16e-05	9	38	2	19228980
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD1 FZD10	4.16e-05	9	38	2	9707618
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD10	5.20e-05	10	38	2	15245425
Pubmed	Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission.	CHRNA3 CHRNB3	6.35e-05	11	38	2	29791835
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD10	6.35e-05	11	38	2	24860427
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD1 FZD10	6.35e-05	11	38	2	30978219
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD10	6.35e-05	11	38	2	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD10	6.35e-05	11	38	2	17576136
Pubmed	Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.	IL12RB2 STAT3	7.62e-05	12	38	2	30759395
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	FZD1 FZD10	9.00e-05	13	38	2	21246654
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	CCN6 NUP85 RUNDC3B YARS1 SUPT16H	1.02e-04	431	38	5	33660365
Pubmed	Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development.	CHRNA3 CHRNB3	1.05e-04	14	38	2	23213462
Pubmed	Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.	CHRNA2 CHRNA3 CHRNB3	1.12e-04	85	38	3	25131634
Pubmed	Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.	CCN6 FZD10	1.21e-04	15	38	2	11597177
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PHF2 DNHD1 DENND4A PAXBP1 CHERP POLE YARS1 SUPT16H	1.27e-04	1425	38	8	30948266
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	MUC19 STAT3	1.38e-04	16	38	2	19068216
Pubmed	Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.	CHRNA3 CHRNB3	1.38e-04	16	38	2	8630490
Pubmed	Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall.	FZD1 FZD10	1.56e-04	17	38	2	25727890
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD1 FZD10	1.56e-04	17	38	2	28733458
Pubmed	Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor.	CHRNA2 CHRNA3	1.76e-04	18	38	2	2338144
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD1 FZD10	1.96e-04	19	38	2	21623369
Pubmed	Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.	FZD1 FZD10	2.65e-04	22	38	2	27913639
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD10	2.65e-04	22	38	2	17064353
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	CHRNA2 CHRNA3 CHRNB3	2.95e-04	118	38	3	19156168
Pubmed	Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.	MUC19 STAT3	4.32e-04	28	38	2	18587394
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD10	4.63e-04	29	38	2	18364260
Pubmed	Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.	IL12RB2 STAT3	4.63e-04	29	38	2	20716621
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PHF2 PAXBP1 CHERP NUP85 YARS1 STAT3 SUPT16H	4.97e-04	1318	38	7	30463901
Pubmed	Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.	MUC19 STAT3	5.30e-04	31	38	2	21072187
Pubmed	Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear.	FZD1 FZD10	6.01e-04	33	38	2	24727668
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD1 FZD10	7.15e-04	36	38	2	24151333
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	FZD1 FZD10	7.56e-04	37	38	2	35831952
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	FZD1 FZD10	7.56e-04	37	38	2	18800919
Pubmed	Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.	CHRNA3 CHRNB3 SCN8A	7.97e-04	166	38	3	19906978
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	FZD1 FZD10	7.97e-04	38	38	2	21041481
Pubmed	Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.	FZD1 BMPER	7.97e-04	38	38	2	22833126
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	CHERP NUP85 POLE SUPT16H	9.34e-04	400	38	4	35013556
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	CHERP ARID2 SUPT16H	1.04e-03	182	38	3	26527279
Cytoband	12q12	MUC19 ARID2	7.04e-04	47	38	2	12q12
Cytoband	Ensembl 112 genes in cytogenetic band chr12q12	MUC19 ARID2	1.26e-03	63	38	2	chr12q12
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA2 CHRNA3 CHRNB3	2.05e-06	16	29	3	173
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD10	1.35e-04	11	29	2	286
Coexpression	GSE16385_UNTREATED_VS_12H_IL4_TREATED_MACROPHAGE_UP	CCN6 LRGUK ASPHD2 RNF183 WDFY2	8.58e-06	199	37	5	M7959
Coexpression	HEVNER_CORTEX_CAUDAL_SUBVENTRICULAR_ZONE	FZD1 CHRNA3 STAT3	2.28e-05	39	37	3	MM441
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CHRNA3 GLCE CHRNB3 CACNA2D3	1.20e-05	166	38	4	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1-Inhibitory_Neuron.Gad1Gad2_Sst.Grm1_(Interneuron,_OLM3_(CA1_enriched?))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADAMTS7 CHRNA2 CHRNB3	1.41e-05	55	38	3	10e98fc862d89141512bdebae1231ef1a82105b0
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1-Inhibitory_Neuron.Gad1Gad2_Sst.Grm1_(Interneuron,_OLM3_(CA1_enriched?))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADAMTS7 CHRNA2 CHRNB3	1.41e-05	55	38	3	a55d3edca2dd9ca7a703b2b3a5941b30b5f0a6df
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADAMTS7 CHRNA2 CHRNB3	1.41e-05	55	38	3	bac333ea3914a49376105dd977a0b8493b0d2001
ToppCell	COVID-19-lung-RBC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SELP DENND4A CHRNA2 EPB42	1.47e-05	175	38	4	4c35292ad2ac712ba7516f27dd6eac6ba8fdd163
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPRASP1 PAXBP1 STAG1 SUPT16H	1.51e-05	176	38	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP IL12RB2 RNF183	4.87e-05	83	38	3	3aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP IL12RB2 RNF183	4.87e-05	83	38	3	70804dd63221dd5ed26068ec1b50f11875abbc50
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP IL12RB2 RNF183	4.87e-05	83	38	3	c1818411438f53aec76afead5c8caab701b95d39
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP IL12RB2 RNF183	4.87e-05	83	38	3	1e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DNHD1 RXFP3 CHRNB3	9.82e-05	105	38	3	c7528276fee8f6d2cb4639069bc87413b0288025
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DNHD1 RXFP3 CHRNB3	9.82e-05	105	38	3	7bcf3345a21a1ade717128be127e9fe12ae40011
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DNHD1 RXFP3 CHRNB3	9.82e-05	105	38	3	62e89b92bb8c5187ab0205aebd018b4178710bb0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RXFP3 CHRNA2 GLCE	1.22e-04	113	38	3	feb3c6a7723263d58e5ce020a0097fedfcf78ca8
ToppCell	VE-CD4-CD8_1\|VE / Condition, Cell_class and T cell subcluster	DNHD1 LRGUK YARS1	1.57e-04	123	38	3	bc0f509716bb71d6e3fa343f4920ecb80eb62794
ToppCell	facs-Aorta-Heart-3m-Myeloid-professional_antigen_presenting_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRGUK NCOA4 CHRNB3	2.25e-04	139	38	3	292533e04178dd36d57377562077f9deb2cb9746
ToppCell	facs-Aorta-Heart-3m-Myeloid-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRGUK NCOA4 CHRNB3	2.25e-04	139	38	3	22a769d5195ed761ef333ef542746e1ba617a698
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FZD1 MUC19 BMPER	2.50e-04	144	38	3	1c001a5a3bbe4ecbce8305f8b260e933033550dd
ToppCell	TCGA-Adrenal\|World / Sample_Type by Project: Shred V9	RXFP3 CHRNA3 CACNA2D3	2.55e-04	145	38	3	522ad2bc90b8ec326fcbc7b2250b09566efeeca2
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Glra3\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHRNA2 GLCE CACNA2D3	2.65e-04	147	38	3	50e86860a94be103092c40e39a172eac92372f0d
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ASPHD2 HOMER3 EPB42	2.81e-04	150	38	3	b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCell	facs-Heart-LV-18m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP DENND4A NCOA4	2.87e-04	151	38	3	771224e0d6fccfa4225b3adccd7bc22a89a40793
ToppCell	facs-Heart-LV-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP DENND4A NCOA4	2.87e-04	151	38	3	5893a51585a65f1902cf85124a5ed9f02b4eb82a
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNHD1 IL12RB2 GLCE	2.87e-04	151	38	3	7270b8bbfae659e110bd9d513b602120b25de3dd
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC19 CHRNB3 CACNA2D3	3.40e-04	160	38	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC19 CHRNB3 CACNA2D3	3.40e-04	160	38	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RXFP3 CHRNA2 GLCE	3.46e-04	161	38	3	dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NCOA4 ADAMTS7 POLE	3.78e-04	166	38	3	49103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP3 HOMER3 CHRNB3	3.85e-04	167	38	3	d26e4cea67177975ba15f393e8521be91e148ac9
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP RUNDC3B SCN8A	3.99e-04	169	38	3	780fb0050852626062a729dd1b82b0cf61e7e9ca
ToppCell	COVID-19-lung-RBC\|lung / Disease (COVID-19 only), tissue and cell type	SELP CHRNA2 EPB42	4.13e-04	171	38	3	0e8d63c8fbccdda4f1ef00de00667a50464b104b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPHD2 GLCE CHRNB3	4.20e-04	172	38	3	cecfe5cf20f317ea01b4604789e07a14481c4cd6
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC12A6 GPRASP1 ASPHD2	4.27e-04	173	38	3	efb8072475000888efe088d00e870c56ffad4172
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SLC12A6 GPRASP1 ASPHD2	4.34e-04	174	38	3	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SELP NCOA4 EPB42	4.41e-04	175	38	3	c33317d8d60ea88ec326daf91dfd3416a62f9938
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RXFP3 RUNDC3B CHRNA3	4.49e-04	176	38	3	116741fef5895ca85057d2d31eca9eba5764ab44
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RXFP3 RUNDC3B CHRNA3	4.49e-04	176	38	3	5b707f58d164ee7a6a527dd5d053472ce9a631c1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHRNA2 WDFY2 CACNA2D3	4.56e-04	177	38	3	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 LRGUK RNF183	4.64e-04	178	38	3	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 LRGUK RNF183	4.64e-04	178	38	3	6178706db4a855d72abc156537604d575624df56
ToppCell	wk_20-22-Hematologic-Meg-ery\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SELP NCOA4 EPB42	4.87e-04	181	38	3	d0637f9ccec5dba4997520b27287989522e04f96
ToppCell	wk_15-18-Hematologic-Meg-ery-Definitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DENND4A NCOA4 EPB42	4.95e-04	182	38	3	93841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	DENND4A NCOA4 EPB42	4.95e-04	182	38	3	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SELP NCOA4 EPB42	4.95e-04	182	38	3	e5e16abf4d3bd5a97e7c573b99f7a3d9a5add120
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD1 GPRASP1 BMPER	5.03e-04	183	38	3	5377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCell	wk_08-11-Epithelial-PNS-PCP4+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHRNA3 CACNA2D3 SCN8A	5.11e-04	184	38	3	eac2a9089913f33a961ba11519b53645790f2056
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD10 CHRNA3 CACNA2D3	5.19e-04	185	38	3	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCN6 BMPER CACNA2D3	5.19e-04	185	38	3	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Control-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	SLC12A6 IL12RB2 STAT3	5.19e-04	185	38	3	e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND4A NCOA4 EPB42	5.19e-04	185	38	3	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCN6 BMPER CACNA2D3	5.19e-04	185	38	3	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-Treg\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC12A6 IL12RB2 DENND4A	5.19e-04	185	38	3	a86a3a1a187a4d8d7762bc6d3dcb22c982178d22
ToppCell	PCW_10-12-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SELP NCOA4 EPB42	5.27e-04	186	38	3	1c39ced3b32dba2832991284720b6c5f508a2e73
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	NCOA4 STAG1 ARID2	5.27e-04	186	38	3	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_reticulocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DENND4A NCOA4 EPB42	5.27e-04	186	38	3	bf8ca7135c05d772aa3f5960b419a13aef3936ae
ToppCell	Multiple_Sclerosis-Other\|Multiple_Sclerosis / Disease, Lineage and Cell Type	SELP NCOA4 EPB42	5.36e-04	187	38	3	ca6f53e841fd016804e6e8ccf0199877b0e5cbdd
ToppCell	COPD\|World / Disease state, Lineage and Cell class	IL12RB2 DENND4A STAT3	5.52e-04	189	38	3	53577632683686dc493a5a3fdc01887ec5c320f2
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 ASPHD2 CACNA2D3	5.69e-04	191	38	3	9d3fa8d8138700640cc7927521c7635299df697d
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	SLC12A6 IL12RB2 STAT3	5.69e-04	191	38	3	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 ASPHD2 CACNA2D3	5.69e-04	191	38	3	d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	SELP BMPER ADAMTS7	5.87e-04	193	38	3	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FZD1 ASPHD2 CACNA2D3	5.87e-04	193	38	3	2b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND4A STAG1 EPB42	5.87e-04	193	38	3	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GPRASP1 RUNDC3B SCN8A	5.87e-04	193	38	3	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FZD1 ASPHD2 CACNA2D3	5.87e-04	193	38	3	90cfc34c2d0d7c70f071703d35db1d6037961481
ToppCell	Megakaryocytic-erythropoietic\|World / Lineage, cell class and subclass	SELP NCOA4 EPB42	5.87e-04	193	38	3	805c2e2e5d8a9df5ce796d5c0206d6493ab53c88
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FZD10 BMPER	5.87e-04	193	38	3	03678162648bd5b1d65a5450b60c8863edbf95c7
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FZD10 BMPER	5.87e-04	193	38	3	59b8186d0221fba06a16157e9d148399ed801f38
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DENND4A NCOA4 EPB42	5.87e-04	193	38	3	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DENND4A NCOA4 EPB42	5.87e-04	193	38	3	305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FZD10 BMPER	5.87e-04	193	38	3	dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DENND4A NCOA4 EPB42	5.87e-04	193	38	3	dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	SELP BMPER ADAMTS7	5.87e-04	193	38	3	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-Unfolded_protein_responsible_cell\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	LRGUK NCOA4 EPB42	6.05e-04	195	38	3	9873de83b67e9645112897d3391c2d9afaa9970e
ToppCell	10x3'2.3-week_12-13-Hematopoietic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SELP NCOA4 EPB42	6.14e-04	196	38	3	05b437af66cb43ba098ea93a02dc2f7430bf8c1b
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SELP SLC12A6 IL12RB2	6.23e-04	197	38	3	54fb7197db3c0dc87a1114e1ab1d2bfafd564b35
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD1 BMPER ADAMTS7	6.23e-04	197	38	3	236a40eb6c08e1d179cf0fb5450b032975c5f6b6
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega\|Control_saline / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.32e-04	198	38	3	1a39a98beef68e1e6d3adc25270a3336fcc5baf4
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|Control_saline / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.32e-04	198	38	3	dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RNF183 EPB42 SCN8A	6.32e-04	198	38	3	28ada093cec552262731194a04a4b9ff93186c3b
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SELP IL12RB2 STAT3	6.32e-04	198	38	3	03423d6c614440b9c738f75ac3f5a6941719a279
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary\|Control_saline / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.32e-04	198	38	3	cfc2a860bae883299987d3e374d0476ca20e1bdd
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.41e-04	199	38	3	565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.41e-04	199	38	3	284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCell	control-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FZD1 ASPHD2 CACNA2D3	6.41e-04	199	38	3	31825ba336603fe940dea6022e18ec25af110f4c
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.41e-04	199	38	3	f894c88ecc7fd0edca28587801fa59352d10f750
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.41e-04	199	38	3	6c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.41e-04	199	38	3	2b754670fe77c2301afcdcfc73a1e52cc0cd1de3
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	PAXBP1 CHRNA3 STAT3	6.51e-04	200	38	3	4db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	PAXBP1 CHRNA3 STAT3	6.51e-04	200	38	3	d46a19274c2836ce7494790ce513764dedcadc79
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	f100edfd2b3b742458cbbf34de9c403c4d272d3c
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	fa1eaf008b54bdf7bbcdec8134460c5f64490de9
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	f99e214eb680fd82a33f2b1524fbfca265d1cc42
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	d85074b362b11e5a523a5325d203a61aa2759a7a
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary\|LPS_only / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	ce8281c9556a1f64f8ca8a029110077d4ef5b35e
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_only / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	83c4181c083b364f0d3a89ae7a0504781fa9fa9f
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_only / Treatment groups by lineage, cell group, cell type	DENND4A NCOA4 EPB42	6.51e-04	200	38	3	f15baf287ec467664c23faa53fdea45257f7b9d0
Computational	AcetylCholine receptors.	CHRNA2 CHRNA3 CHRNB3	4.49e-06	14	26	3	MODULE_328
Computational	Genes in the cancer module 267.	CHRNA2 CHRNA3 CHRNB3	5.61e-06	15	26	3	MODULE_267
Drug	Dns-C6-Cho	CHRNA2 CHRNA3 CHRNB3	6.46e-07	11	37	3	CID000124728
Drug	AC1L9NC9	CHRNA2 CHRNA3 CHRNB3	6.46e-07	11	37	3	CID000449642
Drug	dihydronereistoxin	CHRNA2 CHRNA3 CHRNB3	6.46e-07	11	37	3	CID000121232
Drug	bipinnatin-B	CHRNA2 CHRNA3 CHRNB3	6.46e-07	11	37	3	CID000127363
Drug	LJP 1082	CHRNA2 CHRNA3 CHRNB3	6.46e-07	11	37	3	CID003037609
Drug	AC1L9P8C	CHRNA2 CHRNA3 CHRNB3	8.60e-07	12	37	3	CID000450864
Drug	SureCN373116	CHRNA2 CHRNA3 CHRNB3	8.60e-07	12	37	3	CID010085732
Drug	nereistoxin	CHRNA2 CHRNA3 CHRNB3	1.12e-06	13	37	3	CID000015401
Drug	1-acetyl-4-methylpiperazine methiodide	CHRNA2 CHRNA3 CHRNB3	1.12e-06	13	37	3	CID004392675
Drug	C-toxiferine-I	CHRNA2 CHRNA3 CHRNB3	1.12e-06	13	37	3	CID005089093
Drug	bipinnatin-C	CHRNA2 CHRNA3 CHRNB3	1.12e-06	13	37	3	CID000129977
Drug	bipinnatin-A	CHRNA2 CHRNA3 CHRNB3	1.12e-06	13	37	3	CID000196603
Drug	2,3-dichlorooctafluorobutane	CHRNA2 CHRNA3 CHRNB3	1.42e-06	14	37	3	CID000078982
Drug	LNF 209	CHRNA2 CHRNA3 CHRNB3	1.42e-06	14	37	3	CID000132666
Drug	aa373	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID000191672
Drug	anatoxin-a hydrochloride	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID000135265
Drug	(-)-pictamine	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID006918623
Drug	(-)-lepadin B	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID006918624
Drug	SAD-128	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID000162008
Drug	UB-165	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID004694339
Drug	N-methylcytisine	CHRNA2 CHRNA3 CHRNB3	1.77e-06	15	37	3	CID000234566
Drug	Hexamethonium	CHRNA2 CHRNA3 STAT3	2.18e-06	16	37	3	ctd:D018738
Drug	3-(trifluoromethyl)-3-(m-iodophenyl)diazirine	CHRNA2 CHRNA3 CHRNB3	2.18e-06	16	37	3	CID000123866
Drug	AC1L2SVN	CHRNA2 CHRNA3 CHRNB3	2.18e-06	16	37	3	CID000127922
Drug	benzoquinonium	CHRNA2 CHRNA3 CHRNB3	2.18e-06	16	37	3	CID000009393
Drug	PNU-282,987	CHRNA2 CHRNA3 CHRNB3	2.18e-06	16	37	3	CID004655349
Drug	Nsc36388	CHRNA2 CHRNA3 CHRNB3	2.64e-06	17	37	3	CID000014954
Drug	AC1O8PVM	CHRNA2 CHRNA3 CHRNB3	3.17e-06	18	37	3	CID000004989
Drug	benzetimide	CHRNA2 CHRNA3 CHRNB3	3.17e-06	18	37	3	CID000021846
Drug	ABT-594	CHRNA2 CHRNA3 CHRNB3	3.17e-06	18	37	3	CID003075702
Drug	AC1LCVGE	CHRNA2 CHRNA3 CHRNB3	3.17e-06	18	37	3	CID000656712
Drug	AC1L9P88	CHRNA2 CHRNA3 CHRNB3	3.76e-06	19	37	3	CID000450860
Drug	isoarecolone	CHRNA2 CHRNA3 CHRNB3	3.76e-06	19	37	3	CID000146970
Drug	beta-erythroidine	CHRNA2 CHRNA3 CHRNB3	3.76e-06	19	37	3	CID000010074
Drug	perhydrohistrionicotoxin	CHRNA2 CHRNA3 CHRNB3	3.76e-06	19	37	3	CID000107881
Drug	PNU-120596	CHRNA2 CHRNA3 CHRNB3	3.76e-06	19	37	3	CID000311434
Drug	4-(N-maleimido)benzyltrimethylammonium	CHRNA2 CHRNA3 CHRNB3	3.76e-06	19	37	3	CID000162425
Drug	AC1Q5X7V	CHRNA2 CHRNA3 CHRNB3	4.42e-06	20	37	3	CID000050190
Drug	3-(2-azetidinylmethoxy)pyridine	CHRNA2 CHRNA3 CHRNB3	4.42e-06	20	37	3	CID000001962
Drug	Dichloride, Alcuronium	CHRNA2 CHRNA3 CHRNB3	4.42e-06	20	37	3	CID003032788
Drug	dinotefuran	CHRNA2 CHRNA3 CHRNB3	5.15e-06	21	37	3	CID000197701
Drug	meproadifen	CHRNA2 CHRNA3 CHRNB3	5.15e-06	21	37	3	CID000189752
Drug	suberyldicholine	CHRNA2 CHRNA3 CHRNB3	5.96e-06	22	37	3	CID000123989
Drug	AR-R17779	CHRNA2 CHRNA3 CHRNB3	5.96e-06	22	37	3	CID005310971
Drug	histrionicotoxin	CHRNA2 CHRNA3 CHRNB3	5.96e-06	22	37	3	CID005282247
Drug	clothianidin	CHRNA2 CHRNA3 CHRNB3	5.96e-06	22	37	3	CID000213027
Drug	AC1L3BL8	CHRNA2 CHRNA3 CHRNB3	6.84e-06	23	37	3	CID000086457
Drug	alpha-conotoxin ImI	CHRNA2 CHRNA3 CHRNB3	6.84e-06	23	37	3	CID000133011
Drug	CID6325740	CHRNA2 CHRNA3 CHRNB3	6.84e-06	23	37	3	CID006325740
Drug	ABT-418	CHRNA2 CHRNA3 CHRNB3	6.84e-06	23	37	3	CID000119380
Drug	alpha-conotoxin SI	CHRNA2 CHRNA3 CHRNB3	6.84e-06	23	37	3	CID000163979
Drug	Skpymrfamide	CHRNA2 CHRNA3 CHRNB3	6.84e-06	23	37	3	CID000132661
Drug	procyclidine	CHRNA2 CHRNA3 CHRNB3	7.81e-06	24	37	3	CID000004919
Drug	AC1L2IZE	CHRNA2 CHRNA3 CHRNB3	7.81e-06	24	37	3	CID000072928
Drug	intruder	CHRNA2 CHRNA3 CHRNB3	7.81e-06	24	37	3	CID000213021
Drug	anabaseine	CHRNA2 CHRNA3 CHRNB3	7.81e-06	24	37	3	CID000018985
Drug	anabasine	CHRNA2 CHRNA3 CHRNB3	8.87e-06	25	37	3	CID000002181
Drug	varenicline	CHRNA2 CHRNA3 CHRNB3	8.87e-06	25	37	3	CID000170361
Drug	PrBCM	CHRNA2 CHRNA3 CHRNB3	8.87e-06	25	37	3	CID000037396
Drug	pempidine	CHRNA2 CHRNA3 CHRNB3	8.87e-06	25	37	3	CID000006603
Drug	benzquinamide	CHRNA2 CHRNA3 CHRNB3	1.00e-05	26	37	3	CID000002342
Drug	beta-eudesmol	CHRNA2 CHRNA3 CHRNB3	1.00e-05	26	37	3	CID000091457
Drug	curarine	CHRNA2 CHRNA3 CHRNB3	1.00e-05	26	37	3	CID000198004
Drug	imidazolidine	CHRNA2 CHRNA3 CHRNB3	1.00e-05	26	37	3	CID000449488
Drug	methylcarbamylcholine	CHRNA2 CHRNA3 CHRNB3	1.12e-05	27	37	3	CID000004136
Drug	nornicotine	CHRNA2 CHRNA3 CHRNB3	1.12e-05	27	37	3	CID000000412
Drug	echothiophate	CHRNA2 CHRNA3 CHRNB3	1.26e-05	28	37	3	CID000010547
Drug	pentolinium	CHRNA2 CHRNA3 CHRNB3	1.26e-05	28	37	3	CID000005849
Drug	bromoacetylcholine bromide	CHRNA2 CHRNA3 CHRNB3	1.40e-05	29	37	3	CID000204966
Drug	BAS 012416453; Down 200; 38uM; PC3; HT_HG-U133A	PHF2 DENND4A STAG1 HOMER3 GLCE	1.49e-05	194	37	5	6876_DN
Drug	vecuronium	CHRNA2 CHRNA3 CHRNB3	1.56e-05	30	37	3	CID000039764
Drug	methylenedioxydimethylamphetamine	CHRNA2 CHRNA3 CHRNB3	1.56e-05	30	37	3	CID000551630
Drug	Tiaprofenic acid [33005-95-7]; Down 200; 15.4uM; PC3; HT_HG-U133A	PHF2 RUNDC3B HOMER3 POLE SCN8A	1.60e-05	197	37	5	4091_DN
Drug	AC1L1JK6	CHRNA2 CHRNA3 CHRNB3	1.72e-05	31	37	3	CID000005077
Drug	quinuclidine	CHRNA2 CHRNA3 CHRNB3	1.72e-05	31	37	3	CID000007527
Drug	tetramisole	CHRNA2 CHRNA3 STAT3 CHRNB3	1.84e-05	97	37	4	CID000003913
Drug	S)-cotinine	SELP CHRNA2 CHRNA3 CHRNB3	1.84e-05	97	37	4	CID000000408
Drug	M3/M4	CHRNA2 CHRNA3 CHRNB3	1.90e-05	32	37	3	CID000486507
Drug	tropicamide	CHRNA2 CHRNA3 CHRNB3	1.90e-05	32	37	3	CID000005593
Drug	decamethonium	CHRNA2 CHRNA3 CHRNB3	2.08e-05	33	37	3	CID000002968
Drug	methamidophos	CHRNA2 CHRNA3 CHRNB3	2.08e-05	33	37	3	CID000004096
Drug	cytisine	CHRNA2 CHRNA3 CHRNB3	2.08e-05	33	37	3	CID000010235
Drug	GTS-21	CHRNA2 CHRNA3 CHRNB3	2.28e-05	34	37	3	CID005310985
Drug	thiacloprid	CHRNA2 CHRNA3 CHRNB3	2.28e-05	34	37	3	CID000115224
Drug	l-Lobeline	CHRNA2 CHRNA3 CHRNB3	2.28e-05	34	37	3	CID000003945
Drug	gallamine	CHRNA2 CHRNA3 CHRNB3	2.49e-05	35	37	3	CID000003450
Drug	(+/-)-Epibatidine	CHRNA2 CHRNA3 CHRNB3	2.49e-05	35	37	3	CID000001204
Drug	atracurium	CHRNA2 CHRNA3 CHRNB3	2.49e-05	35	37	3	CID000047319
Drug	EPTC	CHRNA2 CHRNA3 CHRNB3	2.49e-05	35	37	3	CID000012968
Drug	midazolam	SELP CHRNA2 CHRNA3 CHRNB3	2.70e-05	107	37	4	CID000004192
Drug	PhTX-343	CHRNA2 CHRNA3 CHRNB3	2.72e-05	36	37	3	CID000159548
Drug	HHSiD	CHRNA2 CHRNA3 CHRNB3	2.95e-05	37	37	3	CID000003602
Drug	1,2-dichlorohexafluorocyclobutane	CHRNA2 CHRNA3 CHRNB3	2.95e-05	37	37	3	CID000009643
Drug	tiotropium	CHRNA2 CHRNA3 CHRNB3	2.95e-05	37	37	3	CID000060830
Drug	O585	CHRNA2 CHRNA3 CHRNB3	2.95e-05	37	37	3	CID000107646
Drug	Laurdan	CHRNA2 CHRNA3 CHRNB3	3.20e-05	38	37	3	CID000104983
Drug	NSC-293162	CHRNA2 CHRNA3 CHRNB3	3.20e-05	38	37	3	CID000004675
Drug	methylatropine	CHRNA2 CHRNA3 CHRNB3	3.74e-05	40	37	3	CID000005860
Drug	decamethonium	CHRNA2 CHRNA3	3.84e-05	6	37	2	ctd:C033019
Drug	QX-222	CHRNA2 CHRNA3 CHRNB3	4.34e-05	42	37	3	CID000005014
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHRNA2 CHRNA3 CHRNB3	9.24e-07	16	36	3	DOID:3635 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	HOMER3 CHRNA2 CHRNA3 ARID2 CHRNB3	3.82e-06	195	36	5	DOID:1574 (implicated_via_orthology)
Disease	cigarettes per day measurement	PHF2 STAG1 ADAMTS7 CHRNA2 CHRNA3 CHRNB3	1.38e-05	438	36	6	EFO_0006525
Disease	systemic scleroderma, Crohn's disease	IL12RB2 STAT3	1.44e-05	5	36	2	EFO_0000384, EFO_0000717
Disease	smoking cessation	STAG1 ADAMTS7 CHRNA2 CHRNA3 CHRNB3	4.48e-05	325	36	5	EFO_0004319
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	CHRNA3 CHRNB3	9.48e-05	12	36	2	C1861063
Disease	nicotine dependence	CHRNA3 CHRNB3 CACNA2D3	1.19e-04	78	36	3	EFO_0003768
Disease	Neurodevelopmental Disorders	PHF2 CACNA2D3 SCN8A	2.01e-04	93	36	3	C1535926
Disease	atherosclerosis (biomarker_via_orthology)	SELP STAT3	2.71e-04	20	36	2	DOID:1936 (biomarker_via_orthology)
Disease	response to radiation, Hematuria	CCN6 CACNA2D3	3.60e-04	23	36	2	GO_0009314, HP_0000790
Disease	Sjogren's syndrome (is_marker_for)	SELP MUC19	3.93e-04	24	36	2	DOID:12894 (is_marker_for)
Disease	Depressive disorder	SELP CHRNA2 STAT3 CHRNB3	4.15e-04	289	36	4	C0011581
Disease	colorectal cancer (implicated_via_orthology)	POLE STAT3	6.16e-04	30	36	2	DOID:9256 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SVWPENTMCAKFQFT	EPB42	641	P16452
PFDRQNCSMKFGSWT	CHRNB3	161	Q05901
QNCTMKFGSWSYDKA	CHRNA3	171	P32297
RKPGQNFMCLWQSCK	ARID2	1626	Q68CP9
PFDQQNCKMKFGSWT	CHRNA2	191	Q15822
KPNDWTVPKGCFMAN	GLCE	246	O94923
QAQCGQYHKWPMKAA	DNHD1	3401	Q96M86
SFCKWQKSINMKGDA	ADAMTS7	316	Q9UKP4
FCKVDKNLNNSMWGS	DENND4A	176	Q7Z401
CLQGKANWMAFVAPS	IL12RB2	616	Q99665
PNMTFTKTSQKFGQW	HOMER3	66	Q9NSC5
GKNMFWYQQKLGSSP	IGLV11-55	51	A0A075B6I3
VNSKKNQMYFDWGPG	NUP85	16	Q9BW27
AFANSWEMMSCPKGN	MUC19	976	Q7Z5P9
CWSFPMGQKTKGSSN	LRGUK	41	Q96M69
FNKPGANCQRKMAWQ	POLE	656	Q07864
CFPKQWFMNLKGERT	PAXBP1	831	Q9Y5B6
QKFKSPMNTSWCSFN	NCOA4	521	Q13772
QFDCPNEGSFKWKML	CCN6	316	O95389
KCSPIMEQFNFKWPD	FZD10	116	Q9ULW2
QGCEALMNKFGFQWP	FZD1	196	Q9UP38
LMNKFGFQWPDTLKC	FZD1	201	Q9UP38
YKAFSNCSLPQGWKM	ASPHD2	206	Q6ICH7
CKFGNKIFQDGEMWS	BMPER	301	Q8N8U9
GKNWMFSNAKSPPHC	CHERP	176	Q8IWX8
NLKWMACANKGFFTQ	CACNA2D3	406	Q8IZS8
KPIAMNCSNLWGNFS	SELP	711	P16109
INNMTVPSKLWGFFC	SLC12A6	396	Q9UHW9
TNNKSCFWAEKEPCM	GPRASP1	671	Q5JY77
PPFLMDENSWFNKCK	RUNDC3B	256	Q96NL0
ENALDFKWPFGKAMC	RXFP3	141	Q9NSD7
CIAQWKQTNFMTKLG	YARS1	501	P54577
TQFPNFETACWYMGK	PHF2	361	O75151
CWNPFNNTFHTPKML	RNF183	16	Q96D59
KFPGEFMKSWNDCLN	SUPT16H	141	Q9Y5B9
SCQKCDQPFFWNFKQ	WDFY2	286	Q96P53
WAKFCKENMAGKGFS	STAT3	546	P40763
CVFMTFSNPPDWSKN	SCN8A	146	Q9UQD0
MPGPQWKKFRSNFCE	STAG1	166	Q8WVM7