Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	translation activator activity	DAZ4 DAZ1 DAZ3 DAZ2	4.63e-07	15	88	4	GO:0008494
GeneOntologyBiologicalProcess	female meiosis II	DAZ4 DAZ1 DAZ3 DAZ2	4.61e-09	6	88	4	GO:0007147
GeneOntologyBiologicalProcess	meiosis II	DAZ4 DAZ1 DAZ3 DAZ2	4.61e-09	6	88	4	GO:0007135
GeneOntologyBiologicalProcess	meiosis II cell cycle process	DAZ4 DAZ1 DAZ3 DAZ2	4.61e-09	6	88	4	GO:0061983
GeneOntologyBiologicalProcess	regulation of meiotic nuclear division	DAZ4 DAZ1 DAZ3 DAZ2 KNL1	1.35e-06	45	88	5	GO:0040020
GeneOntologyBiologicalProcess	female meiotic nuclear division	DAZ4 MEIKIN DAZ1 DAZ3 DAZ2	2.80e-06	52	88	5	GO:0007143
GeneOntologyBiologicalProcess	positive regulation of meiotic nuclear division	DAZ4 DAZ1 DAZ3 DAZ2	4.30e-06	26	88	4	GO:0045836
GeneOntologyBiologicalProcess	positive regulation of translational initiation	DAZ4 DAZ1 DAZ3 DAZ2	6.77e-06	29	88	4	GO:0045948
GeneOntologyBiologicalProcess	3'-UTR-mediated mRNA stabilization	DAZ4 DAZ1 DAZ3 DAZ2	8.91e-06	31	88	4	GO:0070935
GeneOntologyBiologicalProcess	positive regulation of reproductive process	DAZ4 RNASE10 DAZ1 DAZ3 DAZ2 KNL1	1.14e-05	118	88	6	GO:2000243
GeneOntologyBiologicalProcess	cellular process involved in reproduction in multicellular organism	ERCC1 SPAM1 KMT2D ANGPT2 DAZ4 DAZ1 CFAP57 DAZ3 DAZ2 VPS13B KNL1	1.48e-05	527	88	11	GO:0022412
GeneOntologyBiologicalProcess	positive regulation of meiotic cell cycle	DAZ4 DAZ1 DAZ3 DAZ2	1.83e-05	37	88	4	GO:0051446
GeneOntologyBiologicalProcess	regulation of meiotic cell cycle	DAZ4 DAZ1 DAZ3 DAZ2 KNL1	2.66e-05	82	88	5	GO:0051445
GeneOntologyBiologicalProcess	negative regulation of mRNA catabolic process	A1CF DAZ4 DAZ1 DAZ3 DAZ2	3.54e-05	87	88	5	GO:1902373
GeneOntologyBiologicalProcess	germ cell development	ERCC1 KMT2D ANGPT2 DAZ4 DAZ1 CFAP57 DAZ3 DAZ2 VPS13B KNL1	3.91e-05	482	88	10	GO:0007281
GeneOntologyBiologicalProcess	regulation of translational initiation	DAZ4 PPP1R15B DAZ1 DAZ3 DAZ2	4.39e-05	91	88	5	GO:0006446
GeneOntologyBiologicalProcess	female gamete generation	ERCC1 KMT2D DAZ4 MEIKIN DAZ1 DAZ3 DAZ2	4.75e-05	223	88	7	GO:0007292
GeneOntologyBiologicalProcess	oocyte maturation	DAZ4 DAZ1 DAZ3 DAZ2	4.80e-05	47	88	4	GO:0001556
GeneOntologyBiologicalProcess	regulation of translation	NMNAT2 POLDIP3 INPP5E DAZ4 PPP1R15B SHMT2 DAZ1 TNRC6C DAZ3 DAZ2	4.81e-05	494	88	10	GO:0006417
GeneOntologyBiologicalProcess	oogenesis	ERCC1 KMT2D DAZ4 DAZ1 DAZ3 DAZ2	5.53e-05	156	88	6	GO:0048477
GeneOntologyBiologicalProcess	oocyte development	KMT2D DAZ4 DAZ1 DAZ3 DAZ2	6.58e-05	99	88	5	GO:0048599
GeneOntologyBiologicalProcess	negative regulation of RNA catabolic process	A1CF DAZ4 DAZ1 DAZ3 DAZ2	7.23e-05	101	88	5	GO:1902369
GeneOntologyBiologicalProcess	oocyte differentiation	KMT2D DAZ4 DAZ1 DAZ3 DAZ2	7.94e-05	103	88	5	GO:0009994
GeneOntologyBiologicalProcess	regulation of exosomal secretion	HGS STAM ATP9A	8.12e-05	20	88	3	GO:1903541
GeneOntologyBiologicalProcess	negative regulation of mRNA metabolic process	A1CF DAZ4 DAZ1 DAZ3 DAZ2	1.34e-04	115	88	5	GO:1903312
GeneOntologyBiologicalProcess	exosomal secretion	HGS STAM ATP9A	1.42e-04	24	88	3	GO:1990182
GeneOntologyBiologicalProcess	extracellular exosome biogenesis	HGS STAM ATP9A	1.61e-04	25	88	3	GO:0097734
GeneOntologyBiologicalProcess	negative regulation of GTPase activity	AMOT LRCH1 PLXNB3	2.04e-04	27	88	3	GO:0034260
GeneOntologyBiologicalProcess	extracellular vesicle biogenesis	HGS STAM ATP9A	2.04e-04	27	88	3	GO:0140112
GeneOntologyBiologicalProcess	translational initiation	DAZ4 PPP1R15B DAZ1 DAZ3 DAZ2	2.55e-04	132	88	5	GO:0006413
GeneOntologyBiologicalProcess	positive regulation of nuclear division	DAZ4 DAZ1 DAZ3 DAZ2	2.98e-04	75	88	4	GO:0051785
GeneOntologyBiologicalProcess	positive chemotaxis	ANGPT2 PTPRJ KDR PLXNB3	2.98e-04	75	88	4	GO:0050918
GeneOntologyBiologicalProcess	response to BMP	TGFBR3 HIVEP1 SKOR1 KDR TWSG1 ALPI	3.18e-04	215	88	6	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	TGFBR3 HIVEP1 SKOR1 KDR TWSG1 ALPI	3.18e-04	215	88	6	GO:0071773
GeneOntologyBiologicalProcess	mRNA stabilization	DAZ4 DAZ1 DAZ3 DAZ2	3.30e-04	77	88	4	GO:0048255
GeneOntologyBiologicalProcess	vesicle organization	SEC24D USO1 HGS SEC24B STAM TFG VPS13B KNL1	3.96e-04	415	88	8	GO:0016050
GeneOntologyBiologicalProcess	coronary vasculature morphogenesis	TGFBR3 ARID2 SEC24B	4.08e-04	34	88	3	GO:0060977
GeneOntologyBiologicalProcess	positive regulation of translation	POLDIP3 DAZ4 DAZ1 DAZ3 DAZ2	4.73e-04	151	88	5	GO:0045727
GeneOntologyBiologicalProcess	RNA stabilization	DAZ4 DAZ1 DAZ3 DAZ2	5.49e-04	88	88	4	GO:0043489
GeneOntologyBiologicalProcess	meiotic nuclear division	DAZ4 MEIKIN DAZ1 DAZ3 DAZ2 KNL1	5.70e-04	240	88	6	GO:0140013
GeneOntologyBiologicalProcess	regulation of reproductive process	DAZ4 RNASE10 DAZ1 DAZ3 DAZ2 KNL1	7.21e-04	251	88	6	GO:2000241
GeneOntologyBiologicalProcess	positive regulation of BMP signaling pathway	TGFBR3 KDR TWSG1	7.64e-04	42	88	3	GO:0030513
GeneOntologyBiologicalProcess	coronary artery morphogenesis	ARID2 SEC24B	7.92e-04	10	88	2	GO:0060982
GeneOntologyBiologicalProcess	positive regulation of cellular component biogenesis	EPHB3 SYNPO2 ERCC1 RESF1 PTPRJ PIEZO1 HGS KDR STAM	8.40e-04	582	88	9	GO:0044089
GeneOntologyBiologicalProcess	regulation of nuclear division	DAZ4 DAZ1 DAZ3 DAZ2 KNL1	8.53e-04	172	88	5	GO:0051783
GeneOntologyBiologicalProcess	gamete generation	ERCC1 KMT2D ANGPT2 DAZ4 MEIKIN DAZ1 CFAP57 DAZ3 DAZ2 HERPUD2 VPS13B KNL1	9.26e-04	982	88	12	GO:0007276
GeneOntologyBiologicalProcess	COPII-coated vesicle budding	SEC24D SEC24B TFG	9.35e-04	45	88	3	GO:0090114
GeneOntologyBiologicalProcess	meiotic cell cycle process	DAZ4 MEIKIN DAZ1 DAZ3 DAZ2 KNL1	1.01e-03	268	88	6	GO:1903046
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT2 PCDHGB4 CDH23 IGSF21 PLXNB3	1.24e-03	187	88	5	GO:0007156
GeneOntologyCellularComponent	ESCRT-0 complex	HGS STAM	5.36e-05	3	89	2	GO:0033565
Domain	RRM_1	A1CF POLDIP3 DAZ4 RBM14 DAZ1 TNRC6C DAZ3 DAZ2	5.21e-06	208	86	8	PF00076
Domain	RRM	A1CF POLDIP3 DAZ4 RBM14 DAZ1 TNRC6C DAZ3 DAZ2	7.12e-06	217	86	8	SM00360
Domain	RRM_dom	A1CF POLDIP3 DAZ4 RBM14 DAZ1 TNRC6C DAZ3 DAZ2	9.89e-06	227	86	8	IPR000504
Domain	RRM	A1CF POLDIP3 DAZ4 RBM14 DAZ1 TNRC6C DAZ3 DAZ2	1.09e-05	230	86	8	PS50102
Domain	ZF_CCHC_HIVEP	HIVEP3 HIVEP1	2.10e-05	2	86	2	PS51811
Domain	Nucleotide-bd_a/b_plait	A1CF POLDIP3 DAZ4 RBM14 DAZ1 TNRC6C DAZ3 DAZ2	2.49e-05	258	86	8	IPR012677
Domain	-	A1CF POLDIP3 DAZ4 DAZ1 TNRC6C DAZ3 DAZ2	1.33e-04	244	86	7	3.30.70.330
Domain	Sec23/24_helical_dom	SEC24D SEC24B	3.11e-04	6	86	2	IPR006900
Domain	Sec23_24_beta_S	SEC24D SEC24B	3.11e-04	6	86	2	IPR012990
Domain	zf-Sec23_Sec24	SEC24D SEC24B	3.11e-04	6	86	2	PF04810
Domain	Sec23_trunk	SEC24D SEC24B	3.11e-04	6	86	2	PF04811
Domain	Sec23_helical	SEC24D SEC24B	3.11e-04	6	86	2	PF04815
Domain	Sec23_BS	SEC24D SEC24B	3.11e-04	6	86	2	PF08033
Domain	Sec23/24_trunk_dom	SEC24D SEC24B	3.11e-04	6	86	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC24D SEC24B	3.11e-04	6	86	2	IPR006895
Domain	VHS	HGS STAM	7.39e-04	9	86	2	PF00790
Domain	VHS	HGS STAM	7.39e-04	9	86	2	PS50179
Domain	RFX_DNA_binding	ARID2 RFX1	7.39e-04	9	86	2	PF02257
Domain	DNA-bd_RFX	ARID2 RFX1	7.39e-04	9	86	2	IPR003150
Domain	VHS	HGS STAM	7.39e-04	9	86	2	SM00288
Domain	VHS_dom	HGS STAM	7.39e-04	9	86	2	IPR002014
Domain	RFX_DBD	ARID2 RFX1	7.39e-04	9	86	2	PS51526
Domain	RNAse_Pc	RNASE2 RNASE10	1.12e-03	11	86	2	SM00092
Domain	RNaseA	RNASE2 RNASE10	1.58e-03	13	86	2	PD000535
Domain	Gelsolin	SEC24D SEC24B	1.84e-03	14	86	2	PF00626
Domain	Gelsolin-like_dom	SEC24D SEC24B	1.84e-03	14	86	2	IPR007123
Domain	RNaseA	RNASE2 RNASE10	2.12e-03	15	86	2	IPR001427
Domain	RNaseA_domain	RNASE2 RNASE10	2.12e-03	15	86	2	IPR023412
Domain	RnaseA	RNASE2 RNASE10	2.12e-03	15	86	2	PF00074
Domain	-	RNASE2 RNASE10	2.12e-03	15	86	2	3.10.130.10
Domain	UIM	HGS STAM	3.06e-03	18	86	2	PF02809
Domain	UIM	HGS STAM	4.16e-03	21	86	2	SM00726
Domain	Znf_FYVE_PHD	TRIM66 KMT2D HGS KAT6B	4.75e-03	147	86	4	IPR011011
Domain	PHD	TRIM66 KMT2D KAT6B	5.01e-03	75	86	3	PF00628
Domain	ADF-H/Gelsolin-like_dom	SEC24D SEC24B	5.42e-03	24	86	2	IPR029006
Domain	-	SEC24D SEC24B	5.42e-03	24	86	2	3.40.20.10
Domain	UIM	HGS STAM	5.42e-03	24	86	2	PS50330
Domain	Znf_PHD-finger	TRIM66 KMT2D KAT6B	5.79e-03	79	86	3	IPR019787
Domain	UIM_dom	HGS STAM	5.87e-03	25	86	2	IPR003903
Pathway	WP_OVARIAN_INFERTILITY	DAZ4 DAZ1 DAZ3 DAZ2	2.06e-05	35	66	4	MM15948
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY	PTPRJ HGS STAM	1.23e-04	21	66	3	MM15347
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY	PTPRJ HGS STAM	1.23e-04	21	66	3	M27645
Pubmed	Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	15066457
Pubmed	Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	7670487
Pubmed	Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	11694340
Pubmed	The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	9321470
Pubmed	Polymorphic expression of DAZ proteins in the human testis.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	19223287
Pubmed	Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	11095434
Pubmed	Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	26232607
Pubmed	[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	11688365
Pubmed	Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	12752250
Pubmed	A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	11883873
Pubmed	Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	10936047
Pubmed	[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	16963411
Pubmed	Partial DAZ deletions in a family with five infertile brothers.	DAZ4 DAZ1 DAZ3 DAZ2	4.01e-11	4	89	4	12801575
Pubmed	Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	23579190
Pubmed	Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	22021443
Pubmed	The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	9288969
Pubmed	The dazzle in germ cell differentiation.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	20008336
Pubmed	Co-culture of spermatogonial stem cells with sertoli cells in the presence of testosterone and FSH improved differentiation via up-regulation of post meiotic genes.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	23456578
Pubmed	Isolation of a mouse homolog of the human DAZ (Deleted in Azoospermia) gene.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	8679003
Pubmed	In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	10903443
Pubmed	Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	9143498
Pubmed	Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	22699882
Pubmed	A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	8845845
Pubmed	DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	11058556
Pubmed	AZFc partial deletions in Chilean men with severe spermatogenic failure.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	17416365
Pubmed	Dazl promotes germ cell differentiation from embryonic stem cells.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	19783541
Pubmed	Retinoic acid regulates germ cell differentiation in mouse embryonic stem cells through a Smad-dependent pathway.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	22293198
Pubmed	DAZL protein expression in mouse preimplantation embryo.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	17761180
Pubmed	Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	19468308
Pubmed	Partial rescue of the Dazl knockout mouse by the human DAZL gene.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	12200456
Pubmed	Nature of the spermatogenic arrest in Dazl -/- mice.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	11514340
Pubmed	Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	11089564
Pubmed	Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	23298641
Pubmed	DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	22223682
Pubmed	A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	10393944
Pubmed	The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	8968756
Pubmed	A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	8968755
Pubmed	DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	30380414
Pubmed	Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	26411291
Pubmed	Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	23223451
Pubmed	Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	34985827
Pubmed	Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	11804965
Pubmed	Expression profiling of the developing testis in wild-type and Dazl knockout mice.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	14648873
Pubmed	The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	8896558
Pubmed	Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	9700189
Pubmed	Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	21270429
Pubmed	Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.	DAZ4 DAZ1 DAZ3 DAZ2	2.00e-10	5	89	4	8661148
Pubmed	Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	15066460
Pubmed	DAZL binds to the transcripts of several Tssk genes in germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	18452650
Pubmed	A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	24086306
Pubmed	DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	19247806
Pubmed	DAZL is a master translational regulator of murine spermatogenesis.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	31355046
Pubmed	The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	23417416
Pubmed	The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	32170089
Pubmed	Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	16278232
Pubmed	Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	20157580
Pubmed	A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	17219433
Pubmed	Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	28496037
Pubmed	DAZL regulates Tet1 translation in murine embryonic stem cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	26077710
Pubmed	The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	16001084
Pubmed	Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is Mis-Expressed in Azoospermia Mice.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	32962040
Pubmed	Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	17526644
Pubmed	Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	1869307
Pubmed	A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	11390979
Pubmed	BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	27632217
Pubmed	The mouse male germ cell-specific gene Tpx-1: molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	1638086
Pubmed	Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.99e-10	6	89	4	14611632
Pubmed	Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.	DAZ4 MEIKIN DAZ1 DAZ3 DAZ2	8.17e-10	18	89	5	34075040
Pubmed	Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	10857750
Pubmed	The RNA-binding specificity of the mouse Dazl protein.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	11410654
Pubmed	Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	15081113
Pubmed	Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	22699423
Pubmed	Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	11604102
Pubmed	The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	9588208
Pubmed	DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	26826184
Pubmed	Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.	DAZ4 DAZ1 DAZ3 DAZ2	1.39e-09	7	89	4	16946704
Pubmed	Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	10951504
Pubmed	Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	32339196
Pubmed	Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	33749946
Pubmed	Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	23204224
Pubmed	Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	29883445
Pubmed	A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	10823932
Pubmed	Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	22621333
Pubmed	DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	32686646
Pubmed	A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men.	DAZ4 DAZ1 DAZ3 DAZ2	2.78e-09	8	89	4	11869379
Pubmed	Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.	DAZ4 DAZ1 DAZ3 DAZ2	5.00e-09	9	89	4	16310179
Pubmed	Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	5.00e-09	9	89	4	20159962
Pubmed	A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.	DAZ4 DAZ1 DAZ3 DAZ2	5.00e-09	9	89	4	26378784
Pubmed	Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.	DAZ4 DAZ1 DAZ3 DAZ2	5.00e-09	9	89	4	19695304
Pubmed	The epigenetic modifications and the anterior to posterior characterization of meiotic entry during mouse oogenesis.	DAZ4 DAZ1 DAZ3 DAZ2	5.00e-09	9	89	4	28235998
Pubmed	Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	10601091
Pubmed	Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	31234534
Pubmed	Tesmin transcription is regulated differently during male and female meiosis.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	14648882
Pubmed	MAX controls meiotic entry in sexually undifferentiated germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	38433229
Pubmed	Knockout mouse model and gametogenic failure.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	9922113
Pubmed	SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	23810942
Pubmed	The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.	DAZ4 DAZ1 DAZ3 DAZ2	8.31e-09	10	89	4	12837688
Pubmed	NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells.	DAZ4 DAZ1 DAZ3 DAZ2	1.30e-08	11	89	4	34401671
Pubmed	ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.	KIF23 DAZ4 DAZ1 DAZ3 DAZ2	1.58e-08	31	89	5	31657143
Pubmed	High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia.	DAZ4 DAZ1 DAZ2	1.62e-08	3	89	3	11870237
Interaction	KLF3 interactions	KMT2D HIVEP1 ATXN1 ARID2 QSER1 SAP130 GATAD2B PRDM2	5.90e-06	228	86	8	int:KLF3
Interaction	FHL2 interactions	A1CF BMP2K ATXN1 AMOT ZFR QSER1 RFX1 SAP130 GATAD2B KNL1	7.18e-06	396	86	10	int:FHL2
Interaction	EPHA8 interactions	EPHB3 USO1 PPP1R15B HGS SEC24B STAM TFG	7.93e-06	169	86	7	int:EPHA8
Interaction	ASF1A interactions	KIF23 KMT2D HIVEP1 ARID2 QSER1 SAP130 GATAD2B PRDM2	1.12e-05	249	86	8	int:ASF1A
Interaction	METTL27 interactions	A1CF ATXN1 HGS TFG	1.64e-05	36	86	4	int:METTL27
Interaction	CEBPA interactions	RPGRIP1 KMT2D HIVEP1 RESF1 POLDIP3 ARID2 TLN1 RBM14 ZFR QSER1 MED13L RFX1 SAP130 GATAD2B PCM1 PRDM2 KNL1	1.71e-05	1245	86	17	int:CEBPA
Interaction	GATAD1 interactions	ATXN1 SHMT2 QSER1 HERPUD2 SAP130 GATAD2B	2.07e-05	131	86	6	int:GATAD1
Interaction	SP7 interactions	KMT2D HIVEP1 ATXN1 ARID2 ZFR QSER1 RFX1 SAP130	4.68e-05	304	86	8	int:SP7
Interaction	NFIX interactions	KMT2D HIVEP1 ATXN1 ARID2 QSER1 RFX1 SAP130	5.30e-05	227	86	7	int:NFIX
Interaction	IFITM3 interactions	SEC24D KIF23 PTPRJ POLDIP3 UFD1 HGS SEC24B RBM14 STAM PACSIN2	6.55e-05	513	86	10	int:IFITM3
Interaction	BAG2 interactions	TRIM66 KIF23 ATXN1 AMOT TLN1 HGS QSER1 STAM RFX1 VPS13B KNL1	6.65e-05	622	86	11	int:BAG2
Interaction	SEC31A interactions	SEC24D KIF23 ATXN1 SEC24B SHMT2 STAM TFG	6.77e-05	236	86	7	int:SEC31A
Interaction	FGFR2 interactions	EPHB3 POLDIP3 HGS ITSN2 SEC24B RBM14 STAM	7.33e-05	239	86	7	int:FGFR2
Interaction	EGR2 interactions	KMT2D HIVEP1 RESF1 ATXN1 ARID2 QSER1	9.17e-05	171	86	6	int:EGR2
Interaction	BICD1 interactions	SYNPO2 HGS ITSN2 SEC24B TNRC6C PCM1 ALPI	9.70e-05	250	86	7	int:BICD1
Interaction	EN1 interactions	KMT2D HIVEP1 ATXN1 QSER1 SAP130	1.08e-04	110	86	5	int:EN1
Interaction	CEP55 interactions	KIF23 AMOT HGS RBM14 TNRC6C TFG PCM1	1.12e-04	256	86	7	int:CEP55
Interaction	IFITM1 interactions	SEC24D KIF23 PTPRJ HGS SEC24B RBM14 STAM TFG	1.38e-04	355	86	8	int:IFITM1
Interaction	MED28 interactions	POLR2J SHMT2 MAGI3 STAM MED13L	1.39e-04	116	86	5	int:MED28
Interaction	TBXT interactions	KMT2D HIVEP1 ATXN1 QSER1 SAP130	1.39e-04	116	86	5	int:TBXT
Interaction	HNF1B interactions	KMT2D HIVEP1 ATXN1 ARID2 QSER1 SAP130	1.63e-04	190	86	6	int:HNF1B
Interaction	NLRP13 interactions	KIF23 SHMT2	1.78e-04	5	86	2	int:NLRP13
Interaction	KLF5 interactions	KMT2D HIVEP1 ATXN1 POLDIP3 ARID2 QSER1	1.88e-04	195	86	6	int:KLF5
Interaction	TLE3 interactions	KMT2D HIVEP1 ATXN1 ARID2 RBM14 STAM SAP130 KNL1	2.04e-04	376	86	8	int:TLE3
Interaction	CCDC18 interactions	GALK2 AMOT TNRC6C PCM1	2.04e-04	68	86	4	int:CCDC18
Interaction	GATA2 interactions	KMT2D HIVEP1 ATXN1 ARID2 QSER1 SAP130	2.10e-04	199	86	6	int:GATA2
Interaction	FEV interactions	KMT2D HIVEP1 ATXN1 ARID2 QSER1 RFX1	2.34e-04	203	86	6	int:FEV
Interaction	BRCA1 interactions	RPGRIP1 ERCC1 KIF23 HIVEP1 USO1 MICAL2 TLN1 SEC24B POLR2J RBM14 ZFR TNRC6C TFG GATAD2B KNL1	2.39e-04	1249	86	15	int:BRCA1
Interaction	BET1 interactions	USO1 POLDIP3 HGS SEC24B RBM14 STAM TFG VPS13B	2.39e-04	385	86	8	int:BET1
Cytoband	Yq11.223	DAZ4 DAZ1 DAZ3 DAZ2	3.38e-05	93	89	4	Yq11.223
GeneFamily	RNA binding motif containing	A1CF POLDIP3 DAZ4 RBM14 DAZ1 DAZ3 DAZ2	7.26e-06	213	61	7	725
GeneFamily	ESCRT-0	HGS STAM	3.35e-05	3	61	2	1115
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D TNRC6C MAML3	7.97e-05	25	61	3	775
GeneFamily	Ribonuclease A family	RNASE2 RNASE10	8.53e-04	13	61	2	723
GeneFamily	Cadherin related	FAT2 CDH23	1.47e-03	17	61	2	24
GeneFamily	PHD finger proteins	TRIM66 KMT2D KAT6B	3.49e-03	90	61	3	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D PRDM2	5.86e-03	34	61	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RPGRIP1 ITSN2	6.55e-03	36	61	2	823
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	HIVEP3 TGFBR3 KMT2D RESF1 PTPRJ NFATC2 ATXN1 ARID2 PIEZO1 DOCK9 PPP1R15B TLN1 ITSN2 ZFR TNRC6C HERPUD2 KAT6B VPS13B GATAD2B PCM1 PRDM2	1.98e-08	1492	89	21	M40023
Coexpression	TESAR_JAK_TARGETS_MOUSE_ES_D3_DN	DAZ4 DAZ1 DAZ3 DAZ2	6.02e-08	12	89	4	MM742
Coexpression	SASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN	DAZ4 DAZ1 DAZ3 DAZ2	6.02e-08	12	89	4	MM781
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TGFBR3 SEC24D KIF23 HIVEP1 GALK2 BMP2K ATXN1 MICAL2 DOCK9 ITSN2 SEC24B STAM MED13L KAT6B VPS13B	1.82e-07	856	89	15	M4500
Coexpression	WAGSCHAL_EHMT2_TARGETS_UP	DAZ4 DAZ1 DAZ3 DAZ2	1.05e-06	23	89	4	MM1293
Coexpression	MATZUK_SPERMATOGONIA	DAZ4 DAZ1 DAZ3 DAZ2	3.64e-06	31	89	4	MM765
Coexpression	CHEN_ETV5_TARGETS_TESTIS	DAZ4 DAZ1 DAZ3 DAZ2	4.71e-06	33	89	4	MM701
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	FAT2 KIF23 MICAL2 DOCK9 ZNF264 MED13L KAT6B VPS13B	8.49e-06	300	89	8	M8702
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	FAT2 KIF23 MICAL2 DOCK9 KAT6B VPS13B	1.03e-05	145	89	6	M1810
Coexpression	GSE21033_1H_VS_24H_POLYIC_STIM_DC_UP	HIVEP3 NFATC2 ARID2 SEC24B MAGI3 QSER1	1.87e-05	161	89	6	M7728
Coexpression	GSE13887_RESTING_VS_ACT_CD4_TCELL_UP	NFATC2 MICAL2 RNASE10 LCT GATAD2B	3.41e-05	108	89	5	M478
Coexpression	GSE32533_WT_VS_MIR17_KO_ACT_CD4_TCELL_DN	MAN2B2 RESF1 SEC24B LMBRD2 KAT6B PCM1	5.78e-05	197	89	6	M8464
Coexpression	GSE14769_UNSTIM_VS_360MIN_LPS_BMDM_DN	HIVEP3 KMT2D USO1 POLDIP3 RNASE10 DAZ2	6.29e-05	200	89	6	M3510
Coexpression	GSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_6H_UP	TGFBR3 NFATC2 ATXN1 PIEZO1 TLN1 SHMT2	6.29e-05	200	89	6	M6514
Coexpression	SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP	SYNPO2 KIF23 HIVEP1 ANGPT2 TWSG1 QSER1 KNL1	8.22e-05	305	89	7	M19875
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	HIVEP3 PTPRJ ATXN1 MAGI3 MED13L MAML3 VPS13B	1.36e-07	196	89	7	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HIVEP3 ANGPT2 BMP2K MICAL2 PIEZO1 KDR	1.77e-06	182	89	6	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HIVEP3 ANGPT2 BMP2K MICAL2 PIEZO1 KDR	1.77e-06	182	89	6	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HIVEP3 ANGPT2 BMP2K MICAL2 PIEZO1 KDR	1.77e-06	182	89	6	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Lymphatic\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	TGFBR3 NMNAT2 ANGPT2 PIEZO1 DOCK9 KDR	2.97e-06	199	89	6	88f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFBR3 NMNAT2 ANGPT2 PIEZO1 DOCK9 KDR	2.97e-06	199	89	6	64b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	PTPRJ ATXN1 MAGI3 MED13L MAML3 VPS13B	2.97e-06	199	89	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFBR3 NMNAT2 ANGPT2 PIEZO1 DOCK9 KDR	2.97e-06	199	89	6	2b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 PTPRJ BMP2K MED13L IGSF21 MAML3	3.06e-06	200	89	6	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 PTPRJ BMP2K MED13L IGSF21 MAML3	3.06e-06	200	89	6	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 PTPRJ BMP2K MED13L IGSF21 MAML3	3.06e-06	200	89	6	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 PTPRJ BMP2K MED13L IGSF21 MAML3	3.06e-06	200	89	6	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 PTPRJ BMP2K MED13L IGSF21 MAML3	3.06e-06	200	89	6	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 PTPRJ BMP2K MED13L IGSF21 MAML3	3.06e-06	200	89	6	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RPGRIP1 KMT2D KDR QSER1 TNRC6C	1.36e-05	152	89	5	0652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	BMP2K PPP1R15B TFG LRCH1 PRDM2	1.91e-05	163	89	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	Control-T/NK_proliferative\|World / Disease group and Cell class	KIF23 MAGI3 LTBR ATP9A KNL1	2.27e-05	169	89	5	fca735cbb55fce4d32dc6632a39acea1d16b87ab
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	RNASE2 MEIKIN LCT IGSF21 KNL1	2.61e-05	174	89	5	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NMNAT2 ANGPT2 KDR LRRC70 PLXNB3	2.83e-05	177	89	5	b1775e05c28883a15c56628028770bc59d3233fb
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TGFBR3 ANGPT2 AMOT DOCK9 KDR	2.99e-05	179	89	5	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK9 RNASE10 KDR LRRC70 CFAP57	3.07e-05	180	89	5	755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPGRIP1 ANGPT2 MICAL2 KDR LRRC70	3.49e-05	185	89	5	fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBR3 NMNAT2 ANGPT2 KDR LRRC70	3.59e-05	186	89	5	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	RESF1 ARID2 LRCH1 SAP130 VPS13B	3.59e-05	186	89	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	RNASE2 KIF23 BMP2K LTBR QSER1	3.68e-05	187	89	5	3c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	NMNAT2 ANGPT2 PIEZO1 KDR LRRC70	3.68e-05	187	89	5	55aad84b992412e487a32f4970620189a7380ba6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABHD14A SEC24D KIF23 PIEZO1 SHMT2	3.77e-05	188	89	5	34873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NMNAT2 ANGPT2 PIEZO1 KDR LRRC70	3.87e-05	189	89	5	f0418851ad4042c4cd87c8729e4f0d43bdf8fccb
ToppCell	wk_08-11-Endothelial-Lymph_endothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ANGPT2 MICAL2 DOCK9 KDR LRRC70	3.97e-05	190	89	5	d7f1dc032d161529559e01832d1a3112c6f6cc1a
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NMNAT2 PIEZO1 DOCK9 KDR LRRC70	4.07e-05	191	89	5	d25ac3206fe205a100cfee26431ff32c14c1938f
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	HIVEP1 ARID2 MAGI3 MED13L PCM1	4.17e-05	192	89	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 PIEZO1 DOCK9 KDR LRRC70	4.17e-05	192	89	5	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPRJ ATXN1 MED13L MAML3 VPS13B	4.27e-05	193	89	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 PIEZO1 DOCK9 KDR LRRC70	4.27e-05	193	89	5	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	HIVEP1 ARID2 MAGI3 MED13L PCM1	4.27e-05	193	89	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NMNAT2 ANGPT2 DOCK9 KDR LRRC70	4.38e-05	194	89	5	937ee85ffd50869b60f0f6e91017ab77e8b24c0b
ToppCell	wk_15-18-Endothelial-Lymph_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ANGPT2 PIEZO1 DOCK9 KDR LRRC70	4.60e-05	196	89	5	ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ATXN1 MAGI3 MED13L MAML3 VPS13B	4.83e-05	198	89	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	RESF1 ANGPT2 DOCK9 TLN1 MED13L	5.06e-05	200	89	5	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RESF1 ITSN2 MED13L PCM1 PRDM2	5.06e-05	200	89	5	12f1685ce8f218433068e090c9d839cd5a1910bf
Computational	Neighborhood of IL9	RPGRIP1 SPAM1 ZNF264 LCT RFX1	1.39e-04	93	58	5	MORF_IL9
Computational	Neighborhood of FRK	RPGRIP1 SPAM1 ZNF264 LCT RFX1	3.05e-04	110	58	5	MORF_FRK
Computational	Neighborhood of DCC	RPGRIP1 PTPRJ ZNF264 LCT RFX1	3.31e-04	112	58	5	MORF_DCC
Computational	Neighborhood of LCAT	RPGRIP1 SPAM1 ZNF264 LCT RFX1	7.29e-04	133	58	5	MORF_LCAT
Computational	Neighborhood of EPHA7	RPGRIP1 SPAM1 ZNF264 LCT RFX1	8.89e-04	139	58	5	MORF_EPHA7
Drug	boron trichloride	DAZ4 DAZ1 DAZ3 DAZ2	3.25e-09	6	89	4	CID000025135
Drug	desmethylazelastine	DAZ4 DAZ1 DAZ3 DAZ2	3.83e-07	16	89	4	CID000162558
Drug	molybdenum disulfide	SPAM1 DAZ4 DAZ1 DAZ3 DAZ2	6.97e-07	43	89	5	CID000014823
Drug	propham	RNASE2 DAZ4 DAZ1 DAZ3 DAZ2	7.85e-07	44	89	5	CID000024685
Drug	dazmegrel	DAZ4 DAZ1 DAZ3 DAZ2	8.08e-07	19	89	4	CID000053555
Drug	YM 026	DAZ4 DAZ1 DAZ3 DAZ2	8.08e-07	19	89	4	CID000004443
Drug	AZFd	DAZ4 DAZ1 DAZ3 DAZ2	1.82e-06	23	89	4	CID000196489
Drug	dansylaziridine	DAZ4 DAZ1 DAZ3 DAZ2	1.82e-06	23	89	4	CID000104008
Drug	d-gluconhydroximo-1,5-lactam	DAZ4 DAZ1 DAZ3 DAZ2	6.33e-06	31	89	4	CID000003479
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	GALK2 ITSN2 SEC24B MED13L SAP130 VPS13B PRDM2	7.64e-06	183	89	7	7498_DN
Drug	(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A	HIVEP3 SEC24D POLDIP3 INPP5E QSER1 LRCH1 VPS13B	1.12e-05	194	89	7	3539_DN
Drug	Vistar	DAZ4 DAZ1 DAZ3 DAZ2	1.17e-05	36	89	4	CID000040896
Drug	3-bromo-7-nitroindazole	DAZ4 DAZ1 DAZ3 DAZ2	1.17e-05	36	89	4	CID000001649
Drug	2-chlorodideoxyadenosine	DAZ4 DAZ1 DAZ3 DAZ2	2.40e-05	43	89	4	CID000072194
Drug	bipy	DAZ4 DAZ1 DAZ3 DAZ2 ALPI	3.96e-05	97	89	5	CID000001474
Drug	ridogrel	DAZ4 DAZ1 DAZ3 DAZ2	5.12e-05	52	89	4	CID005362391
Drug	azafagomine	DAZ4 DAZ1 DAZ3 DAZ2	7.36e-05	57	89	4	CID011957435
Drug	arabinopyranose	TGFBR3 GALK2 MAN2B2 HGS LCT ALPI IMPG2	7.43e-05	261	89	7	CID000000229
Disease	Male sterility due to Y-chromosome deletions	DAZ4 DAZ1 DAZ3 DAZ2	4.89e-09	8	87	4	C2931163
Disease	Partial chromosome Y deletion	DAZ4 DAZ1 DAZ3 DAZ2	4.89e-09	8	87	4	C1507149
Disease	Spermatogenic Failure, Nonobstructive, Y-Linked	DAZ1 DAZ3 DAZ2	1.35e-05	16	87	3	C1839071
Disease	SPERMATOGENIC FAILURE, Y-LINKED, 2	DAZ1 DAZ3 DAZ2	1.35e-05	16	87	3	415000
Disease	Spermatogenic failure, Y-linked, 2	DAZ1 DAZ3 DAZ2	1.35e-05	16	87	3	cv:C1839071
Disease	monocyte count	HIVEP3 TGFBR3 NMNAT2 HIVEP1 BMP2K ATXN1 PIEZO1 TLN1 ITSN2 CDH23 LTBR MED13L LCT	1.27e-04	1320	87	13	EFO_0005091
Disease	hereditary lymphedema (is_implicated_in)	ANGPT2 PIEZO1	1.79e-04	7	87	2	DOID:0050580 (is_implicated_in)
Disease	colorectal cancer (is_implicated_in)	ERCC1 PTPRJ ARID2 KDR	4.61e-04	121	87	4	DOID:9256 (is_implicated_in)
Disease	endometrial adenocarcinoma (is_marker_for)	TGFBR3 ANGPT2	4.65e-04	11	87	2	DOID:2870 (is_marker_for)
Disease	retinopathy of prematurity (biomarker_via_orthology)	ANGPT2 KDR	5.56e-04	12	87	2	DOID:13025 (biomarker_via_orthology)
Disease	juvenile polyposis syndrome (implicated_via_orthology)	HIVEP3 HIVEP1	6.56e-04	13	87	2	DOID:0050787 (implicated_via_orthology)
Disease	serum IgE measurement	SYNPO2 TLN1 RNASE10	9.06e-04	64	87	3	EFO_0004579
Disease	cognitive function measurement	NMNAT2 SYNPO2 KMT2D A1CF HIVEP1 ATXN1 PIEZO1 ITSN2 ZFR LMBRD2 MAML3 GATAD2B	1.01e-03	1434	87	12	EFO_0008354
Disease	Hemangiosarcoma	ANGPT2 KDR	1.28e-03	18	87	2	C0018923
Disease	intellectual disability (implicated_via_orthology)	ITSN2 ZNF280B GATAD2B	1.43e-03	75	87	3	DOID:1059 (implicated_via_orthology)
Disease	esophagus adenocarcinoma (is_implicated_in)	ERCC1 KDR	1.74e-03	21	87	2	DOID:4914 (is_implicated_in)
Disease	myeloid white cell count	HIVEP3 PTPRJ ATXN1 MICAL2 INPP5E PIEZO1 CDH23 LTBR LCT	1.77e-03	937	87	9	EFO_0007988
Disease	lung squamous cell carcinoma (is_implicated_in)	KMT2D PTPRJ	2.27e-03	24	87	2	DOID:3907 (is_implicated_in)
Disease	obsessive-compulsive disorder, Tourette syndrome	NFATC2 ATP9A	2.67e-03	26	87	2	EFO_0004242, EFO_0004895

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNVSVPSNNVHAPYS	TWSG1	146	Q9GZX9
YRNSSPQVVPNNSSE	ZNF280B	126	Q86YH2
AAAQASAPAQTQAPT	AMOT	991	Q4VCS5
YAVPNATAPVSAAQL	A1CF	546	Q9NQ94
SSSPYVSNAVQRDAP	ANGPT2	56	O15123
RAPSPQVVYQVASNQ	ARID2	1091	Q68CP9
PAQQNQYVHISSSPQ	ATXN1	241	P54253
SQQQASPEYLTSPQE	BMP2K	556	Q9NSY1
ITPNPVTQHVQAYSA	DAZ2	156	Q13117
ITPNPVTQHVQAYSA	DAZ3	156	Q9NR90
QAFPAYPNSPVQVTT	DAZ3	406	Q9NR90
PPNNQITYSIVSASA	CDH23	591	Q9H251
SSQPAAYVAQPATAA	RBM14	426	Q96PK6
AQNLPDSSPTQNYIS	QSER1	481	Q2KHR3
EPLSSNQPASVTDYQ	ITSN2	846	Q9NZM3
VNVQPYSGSPANLAV	SHMT2	136	P34897
SQSSYIVHVAENNPP	PCDHGB4	451	Q9UN71
SPSVPALENSYAQIS	KAT6B	1616	Q8WYB5
YAQISPDQSAISVPS	KAT6B	1626	Q8WYB5
FVPIAPTSTQNYTQE	ABHD14A	191	Q9BUJ0
SSPDARYQQQNPAAV	NFATC2	736	Q13469
QASPVIHYSPTNQQL	NFATC2	806	Q13469
DPNSTAQYTRPSNVS	PTPRJ	616	Q12913
TSSTIQVAPANYPNE	MED13L	2001	Q71F56
NPSSSNVIYDEQSPL	MAGI3	1116	Q5TCQ9
APSSQSQAYERNAPQ	MAML3	1076	Q96JK9
NVPDTNPYRSSAADV	INPP5E	451	Q9NRR6
TQNNPVYQVSFSPQD	CFAP57	151	Q96MR6
NQQALVKTPSYSSAP	KIAA2026	1831	Q5HYC2
LPTVDTSAQAAPQTY	ERCC1	46	P07992
PYPTASLVSQNESEN	PCM1	466	Q15154
YTANPQLVAAEPSAS	PLXNB3	1011	Q9ULL4
NDNPPTFSQLVYTTS	FAT2	2266	Q9NYQ8
PLYPDFSTSANNIQI	GALK2	86	Q01415
ISNAPQNTCIPSYDT	LCT	691	P09848
SQYSPNEIRENSPAV	LRCH1	521	Q9Y2L9
YAAVNITTNQAAPSE	EPHB3	441	P54753
QVPLAAYNLAPESTS	KNL1	611	Q8NG31
PNVSNYVNSNEIVPV	MEIKIN	301	A0A087WXM9
FSIYTQQSQDPPAQK	ATP9A	426	O75110
INYQPQSSSSVPCQR	GATAD2B	296	Q8WXI9
SSAITLNIYCQNPPS	LRRC70	376	Q7Z2Q7
PDYQQQAAVPLSSET	ALPI	436	P09923
PAQSAQSQSSYNPFE	PACSIN2	351	Q9UNF0
AADTPAPFSRYQAQN	IGSF21	151	Q96ID5
ITPNPVTQHVQAYSA	DAZ1	486	Q9NQZ3
PYTTSTPNINSVRNA	DOCK9	1236	Q9BZ29
YQNATDVPRTSDPQI	GFY	266	I3L273
PSQIQNSTETPSAYD	MAN2B2	511	Q9Y2E5
PSIYLNTQQSPVAAT	SPAM1	261	P38567
YQAAVSAQATSNVNP	HERPUD2	206	Q9BSE4
ITPNPVTQHVQAYSA	DAZ4	321	Q86SG3
YSALYTVPTQNVTPN	SEC24B	91	O95487
PSIPSYNVSFISQTQ	PKD1L1	476	Q8TDX9
QRANSFQSPTPSKYQ	MICAL2	1231	O94851
AQATQNVYVPSTEPE	PRDM2	531	Q13029
VQNDAYTAPALPSSI	POLDIP3	231	Q9BY77
SPVPLSSNYIAQISN	KIF23	686	Q02241
NVYVNSSIPIPSSNS	TAS2R40	166	P59535
PSYPAAQSQAKAVAA	SKOR1	501	P84550
VNQDYFASVNAPSNP	USO1	346	O60763
QTKEQQSSPNTFAPY	TNRC6C	1251	Q9HCJ0
TAIIPASNNPYFRDQ	RPGRIP1	836	Q96KN7
NSNITGLYATANPVP	LMBRD2	76	Q68DH5
AAATPQPQYVTELQS	RFX1	46	P22670
LPSRQTSAVPSQQYA	RESF1	256	Q9HCM1
KFANSVPPNVNNAVY	IMPG2	966	Q9BZV3
PYNPQNFTATIQTAA	PPP1R15B	486	Q5SWA1
SPQNISNCRYAQTPA	RNASE2	116	P10153
NNVASSHAPYQPSAQ	SEC24D	91	O94855
NSIYPPSAAPTAVQQ	ZNF341	91	Q9BYN7
PQAAVASQNYTPKPT	SYNPO2	831	Q9UMS6
VNAASPTNVQASSVY	SYNPO2	1011	Q9UMS6
SQPDQVTPNCNYLTS	RNASE10	181	Q5GAN6
AQTSQPTNYTVAPAS	TFG	331	Q92734
AQAAYLVGVSDPNSQ	TLN1	1441	Q9Y490
EEAPYQQSTSPQRVS	ZNF256	61	Q9Y2P7
QYPVSAQAPNSAITA	SAP130	516	Q9H0E3
YQNVASQAPQSLPAI	HGS	671	O14964
EQQVSPPNTNAKSYA	HIVEP3	401	Q5T1R4
SANPALPSQQTQAAY	STAM	446	Q92783
AASQPQAVPPYASEN	LTBR	26	P36941
SASDQPYQRETPQVS	ZNF264	611	O43296
NLQVATYSKFQPQSP	UFD1	116	Q92890
VAAAAQPQPSVAETY	ZFR	171	Q96KR1
TAAPQYLQPFVSDRN	VPS13B	2501	Q7Z7G8
CANEPSQAVSVTNPY	KDR	466	P35968
PRPSAQSAFQLAYQA	PIEZO1	1436	Q92508
SAQQPSIIPFTAQAY	PIEZO1	2226	Q92508
SSPFYQSHQSPVAQQ	TRIM66	286	O15016
FQNTALPSVNAVPYQ	HIVEP1	1451	P15822
ELITPNSNPYSAFQV	TGFBR3	236	Q03167
QTTPDYSPQEAFTNA	POLR2J	76	P52435
STISPVLYANINFPN	KMT2D	2016	O14686
PIYQNSNVATKPTAA	NMNAT2	136	Q9BZQ4