Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

1.10e-07102757GO:0005249
GeneOntologyMolecularFunctiongated channel activity

ANO4 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5

4.74e-073347510GO:0022836
GeneOntologyMolecularFunctionbeta-galactosidase activity

GLB1L3 GLB1L GLB1L2

5.06e-075753GO:0004565
GeneOntologyMolecularFunctionpotassium channel activity

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

5.21e-07128757GO:0005267
GeneOntologyMolecularFunctionchannel activity

ANO4 GJA3 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5 PKD1L2

5.58e-075257512GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ANO4 GJA3 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5 PKD1L2

5.69e-075267512GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ANO4 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5 PKD1L2

1.09e-064597511GO:0005216
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

1.66e-06152757GO:0022843
GeneOntologyMolecularFunctiongalactosidase activity

GLB1L3 GLB1L GLB1L2

1.76e-067753GO:0015925
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

MAN2B2 GLB1L3 GLB1L HYAL3 GLB1L2 MYORG

2.45e-06103756GO:0004553
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

3.11e-06167757GO:0015079
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 PKD1L2

5.43e-06343759GO:0005261
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

5.48e-06182757GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

5.89e-06184757GO:0022832
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

9.12e-064657510GO:0046873
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

MAN2B2 GLB1L3 GLB1L HYAL3 GLB1L2 MYORG

1.69e-05144756GO:0016798
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO4 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

2.38e-057587512GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO4 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

3.71e-057937512GO:0015075
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO4 ASIC2 KCNH2 KCNJ3 KCNK1 ANO5

8.73e-05193756GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

ANO4 ASIC2 KCNH2 KCNJ3 KCNK1 ANO5

9.77e-05197756GO:0022834
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

1.14e-046277510GO:0022890
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNH2 KCNJ3 KCNK1

1.56e-0428753GO:0005242
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

1.82e-046647510GO:0008324
GeneOntologyMolecularFunctiontransporter activity

ANO4 GJA3 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 NPC1L1 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

2.78e-0412897514GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO4 GJA3 KCNQ5 ASIC2 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

4.13e-0411807513GO:0022857
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

KCNH2 KCNJ3

8.97e-0412752GO:1902282
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

KCNH2 KCNJ3

1.42e-0315752GO:0086008
GeneOntologyMolecularFunctionprotein phosphatase activator activity

PPP2R5B PPP2R5D

1.83e-0317752GO:0072542
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNQ5 KCNJ3

1.83e-0317752GO:0099508
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

ASIC2 KCNH2 KCNJ3 KCNK1

1.91e-03140754GO:0099094
GeneOntologyMolecularFunctionphosphatase activator activity

PPP2R5B PPP2R5D

2.53e-0320752GO:0019211
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO4 ANO5

2.53e-0320752GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO4 ANO5

2.53e-0320752GO:0005229
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

GXYLT2 GYS2 EXT2 EXTL3

2.64e-03153754GO:0008194
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO4 ANO5

3.35e-0323752GO:0017128
GeneOntologyMolecularFunctionglycosyltransferase activity

GXYLT2 GYS2 EXT2 EXTL3 POFUT2

4.57e-03288755GO:0016757
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

ANO4 KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

7.96e-0610177114GO:0098660
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

1.50e-05232717GO:0071805
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ANO4 KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

2.24e-0511157114GO:0034220
GeneOntologyBiologicalProcessregulation of action potential firing threshold

KCNQ2 KCNQ3

3.50e-053712GO:0099611
GeneOntologyBiologicalProcesssubstantia propria of cornea development

KCNQ2 KCNQ3

3.50e-053712GO:1903701
GeneOntologyBiologicalProcessapoptosome assembly

KCNQ2 KCNQ3

3.50e-053712GO:0097314
GeneOntologyBiologicalProcesspotassium ion transport

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

4.16e-05272717GO:0006813
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

6.65e-059227112GO:0098662
GeneOntologyBiologicalProcesscarbohydrate metabolic process

MAN2B2 GLB1L3 GLB1L HYAL3 GYS2 EXT2 GLB1L2 POFUT2 MYORG CHST3

6.99e-056467110GO:0005975
GeneOntologyBiologicalProcesssodium ion transmembrane transport

TMEM168 ASIC2 HECW2 KCNK1 KCNQ2 SLC34A3

8.12e-05208716GO:0035725
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

8.16e-059427112GO:0098655
GeneOntologyBiologicalProcessaction potential initiation

KCNQ2 KCNQ3

1.16e-045712GO:0099610
GeneOntologyBiologicalProcessmetal ion transport

KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

1.43e-0410007112GO:0030001
GeneOntologyBiologicalProcessmonoatomic ion transport

ANO4 KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 ANO5 SLC34A3 PKD1L2

2.11e-0413747114GO:0006811
GeneOntologyBiologicalProcessinhibitory chemical synaptic transmission

KCNQ2 KCNQ3

2.43e-047712GO:0098977
GeneOntologyBiologicalProcesspsychomotor behavior

KCNQ2 KCNQ3

2.43e-047712GO:0036343
GeneOntologyBiologicalProcessexocyst localization

EXOC3L4 RALGAPA2

3.23e-048712GO:0051601
GeneOntologyBiologicalProcesspositive regulation of neurotrophin TRK receptor signaling pathway

PPP2R5B PPP2R5D

3.23e-048712GO:0051388
GeneOntologyBiologicalProcesssodium ion transport

TMEM168 ASIC2 HECW2 KCNK1 KCNQ2 SLC34A3

3.69e-04275716GO:0006814
GeneOntologyBiologicalProcessmonoatomic cation transport

KCNQ5 TMEM168 ASIC2 KCNQ4 KCNH2 KCNJ3 HECW2 KCNK1 KCNQ2 KCNQ3 SLC34A3 PKD1L2

5.44e-0411577112GO:0006812
GeneOntologyBiologicalProcesssensory perception of sound

ASIC2 KCNQ4 KCNQ2 KCNQ3 PKHD1L1

6.04e-04198715GO:0007605
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

3.33e-0891747GO:0008076
GeneOntologyCellularComponentpotassium channel complex

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

8.42e-08104747GO:0034705
GeneOntologyCellularComponentinward rectifier potassium channel complex

KCNH2 KCNJ3 KCNK1

1.70e-074743GO:1902937
GeneOntologyCellularComponentcation channel complex

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

1.97e-05235747GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

3.80e-04378747GO:0034702
GeneOntologyCellularComponentplasma membrane protein complex

GJA3 KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 GPR156 KCNQ2 DUOX2 KCNQ3

4.30e-047857410GO:0098797
HumanPhenoFacial cyanosis

KCNQ2 KCNQ3

3.35e-052302HP:0034031
HumanPhenoCircumoral cyanosis

KCNQ2 KCNQ3

3.35e-052302HP:0032556
DomainK_chnl_volt-dep_KCNQ

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.07e-095734IPR003937
DomainK_chnl_volt-dep_KCNQ_C

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.07e-095734IPR013821
DomainKCNQ_channel

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.07e-095734PF03520
DomainGlyco_hydro_35

GLB1L3 GLB1L GLB1L2

2.29e-074733PF01301
DomainGly_Hdrlase_35_cat

GLB1L3 GLB1L GLB1L2

2.29e-074733IPR031330
DomainGlycoside_Hdrlase_35

GLB1L3 GLB1L GLB1L2

2.29e-074733IPR001944
DomainB-gal_1-like

GLB1L3 GLB1L GLB1L2

2.29e-074733IPR026283
DomainGLYCOSYL_HYDROL_F35

GLB1L3 GLB1L GLB1L2

2.29e-074733PS01182
DomainGlycoside_hydrolase_SF

GLB1L3 GLB1L HYAL3 GLB1L2 MYORG

1.97e-0653735IPR017853
DomainVG_K_chnl

KCNQ5 KCNQ4 KCNQ2 KCNQ3

8.07e-0633734IPR028325
DomainKCNQC3-Ank-G_bd

KCNQ2 KCNQ3

1.51e-052732PF11956
DomainK_chnl_volt-dep_KCNQ2

KCNQ5 KCNQ2

1.51e-052732IPR003947
DomainAnkyrin-G_BS

KCNQ2 KCNQ3

1.51e-052732IPR020969
DomainIon_trans_dom

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

8.37e-05114735IPR005821
DomainIon_trans

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

8.37e-05114735PF00520
DomainPP2A_B56

PPP2R5B PPP2R5D

1.50e-045732IPR002554
DomainB56

PPP2R5B PPP2R5D

1.50e-045732PF01603
DomainGlyco_transf_64

EXT2 EXTL3

1.50e-045732PF09258
DomainExostosin

EXT2 EXTL3

1.50e-045732IPR004263
DomainEXT_C

EXT2 EXTL3

1.50e-045732IPR015338
DomainExostosin

EXT2 EXTL3

1.50e-045732PF03016
DomainAnoct_dimer

ANO4 ANO5

3.12e-047732PF16178
DomainAnoct_dimer

ANO4 ANO5

3.12e-047732IPR032394
Domain-

GLB1L3 GLB1L GLB1L2

3.43e-04357333.20.20.80
DomainGlyco_hydro_catalytic_dom

GLB1L3 GLB1L GLB1L2

4.38e-0438733IPR013781
DomainAnoctamin

ANO4 ANO5

6.64e-0410732PF04547
DomainAnoctamin

ANO4 ANO5

6.64e-0410732IPR007632
Domain-

GLB1L3 GLB1L GLB1L2

2.93e-03737332.60.120.260
Domain-

GXYLT2 EXT2 EXTL3

3.93e-03817333.90.550.10
DomainNucleotide-diphossugar_trans

GXYLT2 EXT2 EXTL3

4.96e-0388733IPR029044
DomainGalactose-bd-like

GLB1L3 GLB1L GLB1L2

5.95e-0394733IPR008979
PathwayREACTOME_POTASSIUM_CHANNELS

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

1.21e-07103547M1073
PathwayBIOCARTA_RACC_PATHWAY

KCNQ5 KCNQ4 KCNQ2 KCNQ3

2.54e-0715544M22002
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

5.88e-0743545M1056
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

PPP2R5D MAN2B2 GLB1L3 GLB1L HYAL3 GYS2 EXT2 GLB1L2 CHST3

1.30e-06288549M16864
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

GLB1L3 GLB1L HYAL3 EXT2 GLB1L2 CHST3

7.16e-06123546MM14623
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

GLB1L3 GLB1L HYAL3 EXT2 GLB1L2 CHST3

8.23e-06126546M695
PathwayREACTOME_KERATAN_SULFATE_DEGRADATION

GLB1L3 GLB1L GLB1L2

2.34e-0515543M691
PathwayREACTOME_KERATAN_SULFATE_DEGRADATION

GLB1L3 GLB1L GLB1L2

2.34e-0515543MM14799
PathwayREACTOME_POTASSIUM_CHANNELS

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1

3.54e-0598545MM14545
PathwayWP_PROTEOGLYCAN_BIOSYNTHESIS

EXT2 EXTL3 CHST3

4.16e-0518543M39865
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

GLB1L3 GLB1L EXT2 GLB1L2

5.28e-0554544MM14633
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

GLB1L3 GLB1L EXT2 GLB1L2

6.53e-0557544M692
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

MAN2B2 GLB1L3 GLB1L HYAL3 EXT2 GLB1L2 CHST3

7.35e-05271547MM15406
PathwayREACTOME_HS_GAG_DEGRADATION

GLB1L3 GLB1L GLB1L2

8.91e-0523543MM14804
PathwayREACTOME_HS_GAG_DEGRADATION

GLB1L3 GLB1L GLB1L2

1.02e-0424543M636
PathwayREACTOME_GLYCOSPHINGOLIPID_CATABOLISM

GLB1L3 GLB1L GLB1L2

2.92e-0434543MM17076
PathwayWP_GLYCOGEN_METABOLISM

PPP2R5B PPP2R5D GYS2

2.92e-0434543MM15985
PathwayREACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

GLB1L3 GLB1L GLB1L2

3.47e-0436543M690
PathwayREACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

GLB1L3 GLB1L GLB1L2

3.47e-0436543MM14632
PathwayREACTOME_GLYCOSPHINGOLIPID_CATABOLISM

GLB1L3 GLB1L GLB1L2

4.40e-0439543M48042
PathwayWP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION

PPP2R5B PPP2R5D GYS2

4.75e-0440543M39595
PathwayWP_ACETAMINOPHEN_IN_ANALGESIA_AND_ANTIPYRESIS

KCNQ2 KCNQ3

5.10e-049542M48307
PathwayWP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS

EXT2 EXTL3 CHST3

5.11e-0441543M48095
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNQ5 KCNQ4 KCNH2

5.11e-0441543MM14546
PathwayKEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS

EXT2 EXTL3

7.75e-0411542M47921
PathwayREACTOME_NEURONAL_SYSTEM

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

9.24e-04411547M735
PathwayREACTOME_GLYCOSPHINGOLIPID_METABOLISM

GLB1L3 GLB1L GLB1L2

1.09e-0353543MM14647
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

ANO4 ANO5

1.09e-0313542M46426
PathwayREACTOME_GLYCOSPHINGOLIPID_METABOLISM

GLB1L3 GLB1L GLB1L2

1.41e-0358543M576
PathwayREACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS

PPP2R5B PPP2R5D

1.46e-0315542M27407
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE

PPP2R5B PPP2R5D

1.67e-0316542M47870
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

PPP2R5B PPP2R5D

1.89e-0317542MM15096
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2R5B PPP2R5D

1.89e-0317542M27083
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

PPP2R5B PPP2R5D

1.89e-0317542M919
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2R5B PPP2R5D

2.12e-0318542MM14759
PathwayWP_KCNQ2RELATED_EPILEPSIES

KCNQ2 KCNQ3

2.36e-0319542M48320
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2R5B PPP2R5D

2.36e-0319542M47525
PathwayKEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING

PPP2R5B PPP2R5D

2.62e-0320542M47876
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2R5B PPP2R5D

2.89e-0321542M5876
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2R5B PPP2R5D

2.89e-0321542MM14996
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2R5B PPP2R5D

3.17e-0322542M47919
Pubmed

The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.

KCNQ5 KCNQ4 KCNQ2 KCNQ3

9.95e-11575420132415
Pubmed

Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase.

KCNQ5 KCNQ4 KCNQ2 KCNQ3

9.95e-11575415304482
Pubmed

Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.

KCNQ5 KCNQ4 KCNQ3

9.63e-09375326969140
Pubmed

Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation.

KCNQ5 KCNQ2 KCNQ3

9.63e-09375312890507
Pubmed

Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.

KCNQ5 KCNQ4 KCNQ3

9.63e-09375318786918
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

2.21e-0813975716985003
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

2.53e-084075516382104
Pubmed

Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.

KCNQ4 KCNQ2 KCNQ3

3.85e-08475310713961
Pubmed

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.

KCNQ4 KCNQ2 KCNQ3

3.85e-08475312524525
Pubmed

The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels.

KCNQ5 KCNQ2 KCNQ3

1.92e-07675312032157
Pubmed

Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.

KCNQ5 KCNQ4 KCNQ3

1.92e-07675321730298
Pubmed

Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.

KCNQ2 KCNQ3

4.59e-06275215608631
Pubmed

Benign neonatal sleep myoclonus: an autosomal dominant form not allelic to KCNQ2 or KCNQ3.

KCNQ2 KCNQ3

4.59e-06275222447848
Pubmed

Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.

KCNQ2 KCNQ3

4.59e-06275216319223
Pubmed

Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.

KCNQ2 KCNQ3

4.59e-06275219453707
Pubmed

Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.

KCNQ2 KCNQ3

4.59e-06275223716673
Pubmed

Developmental changes in KCNQ2 and KCNQ3 expression in human brain: possible contribution to the age-dependent etiology of benign familial neonatal convulsions.

KCNQ2 KCNQ3

4.59e-06275218166285
Pubmed

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.

KCNQ4 KCNQ3

4.59e-06275210025409
Pubmed

Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.

KCNQ2 KCNQ3

4.59e-06275223650395
Pubmed

Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy.

KCNQ2 KCNQ3

4.59e-06275232580997
Pubmed

Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.

KCNQ2 KCNQ3

4.59e-06275218483067
Pubmed

Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.

KCNQ2 KCNQ3

4.59e-0627529872318
Pubmed

KCNQ channels show conserved ethanol block and function in ethanol behaviour.

KCNQ2 KCNQ3

4.59e-06275223209695
Pubmed

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.

KCNQ2 KCNQ3

4.59e-0627529836639
Pubmed

Impacted spike frequency adaptation associated with reduction of KCNQ2/3 exacerbates seizure activity in temporal lobe epilepsy.

KCNQ2 KCNQ3

4.59e-06275238049972
Pubmed

Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.

KCNQ2 KCNQ3

4.59e-06275224843134
Pubmed

Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.

KCNQ2 KCNQ3

4.59e-06275210684873
Pubmed

Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.

KCNQ2 KCNQ3

4.59e-06275225740509
Pubmed

Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.

KCNQ2 KCNQ3

4.59e-06275223002961
Pubmed

Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea.

KCNQ2 KCNQ3

4.59e-06275218827480
Pubmed

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.

KCNQ5 KCNQ4

4.59e-06275218536747
Pubmed

Functional analysis of novel KCNQ2 and KCNQ3 gene variants found in a large pedigree with benign familial neonatal convulsions (BFNC).

KCNQ2 KCNQ3

4.59e-06275216235065
Pubmed

Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.

KCNQ2 KCNQ3

4.59e-06275210953053
Pubmed

Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells.

KCNQ5 KCNQ3

4.59e-06275211159685
Pubmed

Does diacylglycerol regulate KCNQ channels?

KCNQ2 KCNQ3

4.59e-06275216721610
Pubmed

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.

KCNQ2 KCNQ3

4.59e-06275216990515
Pubmed

Novel role of KCNQ2/3 channels in regulating neuronal cell viability.

KCNQ2 KCNQ3

4.59e-06275220885443
Pubmed

The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits.

KCNQ2 KCNQ3

4.59e-06275210713399
Pubmed

Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.

KCNQ2 KCNQ3

4.59e-06275210908292
Pubmed

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.

KCNQ5 KCNQ2

4.59e-06275235320039
Pubmed

The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement.

KCNQ2 KCNQ3

4.59e-06275222334706
Pubmed

Calmodulin orchestrates the heteromeric assembly and the trafficking of KCNQ2/3 (Kv7.2/3) channels in neurons.

KCNQ2 KCNQ3

4.59e-06275224333508
Pubmed

Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation.

KCNQ2 KCNQ3

4.59e-06275215483133
Pubmed

Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium.

KCNQ2 KCNQ3

4.59e-06275212832524
Pubmed

C-terminal interaction of KCNQ2 and KCNQ3 K+ channels.

KCNQ2 KCNQ3

4.59e-06275212640002
Pubmed

Direct neurotransmitter activation of voltage-gated potassium channels.

KCNQ5 KCNQ3

4.59e-06275229748663
Pubmed

KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes.

KCNQ2 KCNQ3

4.59e-06275218625963
Pubmed

KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.

KCNQ2 KCNQ3

4.59e-06275226733196
Pubmed

Inactivation as a new regulatory mechanism for neuronal Kv7 channels.

KCNQ5 KCNQ4

4.59e-06275217237198
Pubmed

N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.

KCNQ2 KCNQ3

4.59e-06275218089837
Pubmed

Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.

KCNQ5 KCNQ4

4.59e-06275219389803
Pubmed

Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP2) Affinity and Signaling Sensitivities in Smooth Muscle Cells.

KCNQ5 KCNQ4

4.59e-06275231871302
Pubmed

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.

KCNQ5 KCNQ4

4.59e-06275223408425
Pubmed

KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.

KCNQ2 KCNQ3

4.59e-06275214534157
Pubmed

Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.

KCNQ2 KCNQ3

4.59e-06275210854243
Pubmed

Pharmacophore modeling, 3D-QSAR, and in silico ADME prediction of N-pyridyl and pyrimidine benzamides as potent antiepileptic agents.

KCNQ2 KCNQ3

4.59e-06275227607834
Pubmed

The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.

KCNQ2 KCNQ3

4.59e-06275226627826
Pubmed

KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.

KCNQ2 KCNQ3

4.59e-06275237607817
Pubmed

Regulation of Kv7.2/Kv7.3 channels by cholesterol: Relevance of an optimum plasma membrane cholesterol content.

KCNQ2 KCNQ3

4.59e-06275229474891
Pubmed

Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell.

KCNQ2 KCNQ3

4.59e-06275210479678
Pubmed

KCNQ2-Related Disorders

KCNQ2 KCNQ3

4.59e-06275220437616
Pubmed

Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.

KCNQ2 KCNQ3

4.59e-0627529677360
Pubmed

Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents.

KCNQ2 KCNQ3

4.59e-06275219060215
Pubmed

DNA methylation and expression of KCNQ3 in bipolar disorder.

KCNQ2 KCNQ3

4.59e-06275225041603
Pubmed

Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.

KCNQ2 KCNQ3

4.59e-06275210788442
Pubmed

Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures.

KCNQ2 KCNQ3

4.59e-06275221466805
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ERGIC1 GXYLT2 MAN2B2 BRI3BP HYAL3 EXT2 EXTL3 GLB1L2 POFUT2 MYORG DMXL1 CHST3

9.55e-061201751235696571
Pubmed

SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.

KCNQ2 KCNQ3

1.37e-05375228793216
Pubmed

Novel KCNQ2 and KCNQ3 mutations in a large cohort of families with benign neonatal epilepsy: first evidence for an altered channel regulation by syntaxin-1A.

KCNQ2 KCNQ3

1.37e-05375224375629
Pubmed

Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes.

KCNJ3 KCNQ2

1.37e-05375212458027
Pubmed

Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex.

KCNQ2 KCNQ3

1.37e-05375227564677
Pubmed

Identification of potassium channel proteins Kv7.2/7.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1.

KCNQ2 KCNQ3

1.37e-05375230885609
Pubmed

The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.

KCNQ2 KCNQ3

1.37e-05375234509475
Pubmed

Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.

KCNQ2 KCNQ3

1.37e-05375226312501
Pubmed

Sodium and potassium channel dysfunctions in rare and common idiopathic epilepsy syndromes.

KCNQ2 KCNQ3

1.37e-05375219464834
Pubmed

Kv7 channels can function without constitutive calmodulin tethering.

KCNQ2 KCNQ3

1.37e-05375221980481
Pubmed

KCNQ2 is a nodal K+ channel.

KCNQ2 KCNQ3

1.37e-05375214762142
Pubmed

Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.

KCNQ5 KCNQ4

1.37e-05375224297175
Pubmed

Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability.

KCNQ2 KCNQ3

1.37e-05375224719109
Pubmed

M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.

KCNQ2 KCNQ3

1.37e-05375211034315
Pubmed

Regulation of neuronal M-channel gating in an isoform-specific manner: functional interplay between calmodulin and syntaxin 1A.

KCNQ2 KCNQ3

1.37e-05375221976501
Pubmed

Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.

KCNQ5 KCNQ4

1.37e-05375217519950
Pubmed

Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.

PPP2R5B PPP2R5D

1.37e-05375225972378
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TBC1D16 CTC1 KCNH2 KMT5C KCNQ2 TWNK EXTL3 MBD5 RALGAPA2 MYORG WDR24

2.42e-051105751135748872
Pubmed

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.

EXT2 EXTL3

2.75e-05475217761672
Pubmed

Genetic testing in benign familial epilepsies of the first year of life: clinical and diagnostic significance.

KCNQ2 KCNQ3

2.75e-05475223360469
Pubmed

Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity.

PPP2R5D KCNQ2

2.75e-05475220592205
Pubmed

A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.

KCNQ2 KCNQ3

2.75e-05475216525039
Pubmed

Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1).

KCNJ3 KCNK1

2.75e-0547529506712
Pubmed

Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse.

KCNQ2 KCNQ3

2.75e-05475210087209
Pubmed

Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.

KCNQ2 KCNQ3

4.57e-05575223259949
Pubmed

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice.

PPP2R5B PPP2R5D

4.57e-05575215095873
Pubmed

Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.

KCNH2 KCNJ3

4.57e-05575228464250
Pubmed

Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.

PPP2R5B PPP2R5D

4.57e-0557528812429
Pubmed

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.

EXT2 EXTL3

4.57e-05575210639137
Pubmed

An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels.

KCNQ2 KCNQ3

4.57e-05575225998125
Pubmed

Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.

KCNQ2 KCNQ3

6.84e-05675210781098
Pubmed

Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels.

KCNQ2 KCNQ3

6.84e-05675212223552
Pubmed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

KCNQ2 KCNQ3

6.84e-05675227445338
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO4 ANO5

6.84e-05675215067359
InteractionKCNQ3 interactions

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.68e-0624744int:KCNQ3
InteractionKCNS1 interactions

KCNQ4 KCNQ2 KCNQ3

5.60e-0610743int:KCNS1
InteractionFAM43A interactions

PPP2R5B PPP2R5D PIPSL FAM43A

9.02e-0636744int:FAM43A
GeneFamilyPotassium voltage-gated channels

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

6.53e-0840485274
GeneFamilyExostosin glycosyltransferase family

EXT2 EXTL3

6.87e-055482431
GeneFamilyAnoctamins

ANO4 ANO5

3.06e-0410482865
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R5B PPP2R5D

7.09e-0415482696
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ASIC2 HECW2 RALGAPA2 PKHD1L1 FAM43A

1.43e-0518574536ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ASIC2 HECW2 RALGAPA2 PKHD1L1 FAM43A

1.43e-051857454a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell10x5'v1-week_17-19-Hematopoietic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KCNQ4 KCNH2 EXOC3L4 GYS2 PKHD1L1

1.54e-05188745c00ba0abd0c7bb2c8f9166a2ac6220aae4f4d857
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 GHSR KCNH2 KCNJ3 SLC34A3

1.98e-051987458f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 GHSR KCNH2 KCNJ3 SLC34A3

1.98e-05198745e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNQ5 ASIC2 KCNJ3 HECW2 KCNQ3

1.98e-051987450ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

KCNQ5 ASIC2 KCNJ3 HECW2 KCNQ3

2.07e-0520074548d801219bc771d6c7e151dc88ca4c179988de85
DrugThallium

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNQ2 KCNQ3

5.79e-1122726ctd:D013793
DrugQuinazolinones

KCNQ5 KCNQ4 KCNQ2 KCNQ3

4.58e-105724ctd:D052999
DrugN-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.37e-096724ctd:C476437
Drugisovaleramide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

6.37e-098724CID000010930
Drugvalrocemide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

6.37e-098724CID006918293
Drugeslicarbazepine acetate

KCNQ5 KCNQ4 KCNQ2 KCNQ3

6.37e-098724CID000179344
DrugCCD 1042

KCNQ5 KCNQ4 NPC1L1 KCNQ2 KCNQ3

1.39e-0825725CID000038022
DrugE 4031

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNQ2 KCNQ3

1.85e-0854726CID000003184
Drugezogabine

KCNQ4 KCNQ2 KCNQ3

3.03e-083723ctd:C101866
DrugXE991

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

6.08e-0833725CID000656732
DrugBMS-204352

KCNQ5 KCNQ4 KCNQ2 KCNQ3

6.43e-0813724CID000214350
Drugbenzanilide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.63e-0716724CID000007168
Drugcarisbamate

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.63e-0716724CID006918474
Druglinopirdine

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

2.41e-0743725CID000003932
DrugPro-val

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

3.80e-0747725CID000142984
DrugAC1Q646P

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

3.80e-0747725CID000005673
Drugretigabine

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

4.23e-0748725CID000121892
Drugrufinamide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

2.06e-0629724CID000129228
Drugvalnoctamide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

2.71e-0631724CID000020140
Drugniflumic acid

GJA3 KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

2.82e-06125726CID000004488
Drugsotalol

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

3.49e-0673725CID000005253
Drugdiazoxide

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

7.59e-06227727CID000003019
Drugtetraethylammonium

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

9.77e-06236727CID000005413
DrugLY 300164

KCNQ5 KCNQ4 KCNQ2 KCNQ3

1.03e-0543724CID000126756
Drug4-AP

KCNQ5 KCNQ4 KCNH2 KCNJ3 KCNK1 KCNQ2 KCNQ3

1.74e-05258727CID000001727
Druglacosamide

KCNQ5 KCNQ4 KCNQ2 KCNQ3

2.22e-0552724CID000219078
Drugglibenclamide

KCNQ5 KCNQ4 KCNH2 KCNJ3 GYS2 KCNK1 KCNQ2 KCNQ3

2.74e-05382728CID000003488
Druglinopirdine

KCNQ2 KCNQ3

2.95e-053722ctd:C061017
Drug(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide

KCNQ4 KCNQ2

2.95e-053722ctd:C576869
DrugFluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; PC3; HT_HG-U133A

PPP2R5B CTC1 TBC1D22A KCNH2 EXTL3 CHST3

3.67e-051967265741_DN
DrugAC1L9NAZ

ANO4 GHSR MMEL1 GYS2 DUOX2 ANO5

3.89e-05198726CID000449606
Drug1-chloro-1,2,2-trifluorocyclobutane

KCNH2 KCNJ3 KCNQ2

5.85e-0524723CID000079091
DrugQuinidine

KCNH2 KCNK1

5.89e-054722DB00908
Drug10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone

KCNQ2 KCNQ3

5.89e-054722ctd:C112297
DrugGDP-Man

ANO4 PIK3R4 MAN2B2 ANO5 POFUT2

8.22e-05140725CID000000732
Drugclofilium

KCNQ4 KCNH2 KCNK1 KCNQ2

8.95e-0574724CID000002798
Drugbarium

KCNQ5 KCNH2 KCNJ3 KCNK1 KCNQ3

1.07e-04148725CID000104810
Drugacotiamide

GHSR KCNH2 KCNJ3

2.18e-0437723CID005282338
Diseaselong QT syndrome (implicated_via_orthology)

KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

2.01e-1110735DOID:2843 (implicated_via_orthology)
Diseaseheart conduction disease (implicated_via_orthology)

MMEL1 KCNQ5 KCNQ4 KCNH2 KCNQ2 KCNQ3

1.60e-1032736DOID:10273 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ5 KCNQ4 KCNQ2 KCNQ3

2.42e-0813734DOID:0112202 (implicated_via_orthology)
DiseaseBenign neonatal seizures

KCNQ2 KCNQ3

6.04e-062732cv:C0220669
Diseasebenign neonatal seizures (implicated_via_orthology)

KCNQ2 KCNQ3

6.04e-062732DOID:14264 (implicated_via_orthology)
Diseasebenign neonatal seizures (is_implicated_in)

KCNQ2 KCNQ3

1.81e-053732DOID:14264 (is_implicated_in)
Diseasehereditary multiple exostoses (implicated_via_orthology)

EXT2 EXTL3

3.61e-054732DOID:206 (implicated_via_orthology)
DiseaseFamilial benign neonatal epilepsy

KCNQ2 KCNQ3

9.00e-056732C0220669
Disease4-acetamidobutanoate measurement

TBC1D22A DENND6B

7.08e-0416732EFO_0021003
DiseaseDisproportionate short stature

ANO5 EXT2 CHST3

9.32e-0477733C0878659
DiseaseBrain Diseases

CTC1 KCNQ2

1.75e-0325732C0006111
Diseaseintestinal permeability measurement

PPP2R5D ASIC2

1.89e-0326732EFO_0011031
DiseaseEncephalopathies

CTC1 KCNQ2

2.04e-0327732C0085584
DiseaseQT interval

ASIC2 KCNQ4 KCNH2 KCNQ3 MBD5 CNOT1

2.09e-03534736EFO_0004682
Disease1,5 anhydroglucitol measurement

RAB3GAP1 PKD1L2

2.35e-0329732EFO_0008009

Protein segments in the cluster

PeptideGeneStartEntry
SWPHLQLVYEFFLRF

PPP2R5B

161

Q15173
FPAWEVYLRAFHSAV

EXOC3L4

306

Q17RC7
GRTYFVKIHAPWEVL

ANO5

126

Q75V66
HVVFGRFFWIVRVVL

BRI3BP

151

Q8WY22
RWFEFLHPGQVYRLI

CTC1

806

Q2NKJ3
QVHFGRWLIEGSPYV

GYS2

101

P54840
AWPHLQLVYEFFLRF

PPP2R5D

206

Q14738
WHPRIVAALVGFLYD

ARMC5

386

Q96C12
IFVKLHAPWEVLGRY

ANO4

161

Q32M45
WLGLYRRFFKSPHFD

DENND6B

481

Q8NEG7
VYLAHPRAVNGFSWR

DMXL1

226

Q9Y485
LWPGRVGRHSLYFNV

ADAMTS14

96

Q8WXS8
HIFVYGPLTIRRVLW

ASIC2

31

Q16515
WYGLREFVVIAPAAH

RAB3GAP1

121

Q15042
HFGVVTARYRWVAGV

SLC34A3

476

Q8N130
PNWEARIDSHGRIFY

HECW2

811

Q9P2P5
RYEFLWGPRAHSEVI

MAGEC1

1066

O60732
HWARRYGLPYVVRVD

KMT5C

391

Q86Y97
GGSIHYFRVPREYWR

GLB1L3

91

Q8NCI6
RSPWFILVGRAFVYL

KIF1B

966

O60333
TRRPVLYFHIRWGFS

KCNK1

161

O00180
ERPRGWALLYHALVF

KCNQ3

116

O43525
RPRGWAFIYHAFVFL

KCNQ5

121

Q9NR82
PGRIAVHYFKGWFLI

KCNH2

486

Q12809
LERPRGWAFVYHVFI

KCNQ4

91

P56696
RYVPFDAAVDFHRWI

DUOX2

1116

Q9NRD8
PLFRELWRYHFATGV

KLHDC10

126

Q6PID8
ERPRGWAFIYHAYVF

KCNQ2

86

O43526
HTGRIIPAIWFRYDL

ERGIC1

221

Q969X5
IPKIGWYSRFARHPF

GXYLT2

246

A0PJZ3
PYLEQFRRIVFWLGD

TWNK

296

Q96RR1
YQFACGGWLRRHVIP

MMEL1

116

Q495T6
LPERIFFRWHYQSIG

RALGAPA2

96

Q2PPJ7
RWTFEEGIKRPYFHV

PRPF39

331

Q86UA1
VSVHRPGFYAEWFQR

PIPSL

376

A2A3N6
GWHPFVVAAELIYFL

PKD1L2

2181

Q7Z442
VYETPDRLWDLGRHF

KBTBD8

571

Q8NFY9
YAPFLLHWITRGVVL

NPC1L1

836

Q9UHC9
HLGRAAYIQPWRFRV

CCDC105

61

Q8IYK2
GTPWEFHAQRGYRVV

LACTBL1

301

A8MY62
AFILCWLPFHVGRYL

GHSR

271

Q92847
DRIVGFPGRYHAWDI

EXTL3

766

O43909
RVAQALRPHGLWGFY

HYAL3

186

O43820
GSLHYFRVPRVLWAD

GLB1L

51

Q6UWU2
DARLPKVFAWVYRHE

FAM43A

146

Q8N2R8
IIHEGPSVYRIFKRW

MARCHF4

291

Q9P2E8
LYETFGIRPQFSWHV

MAN2B2

136

Q9Y2E5
IHYRPRTFNVGDLVW

MBD5

1376

Q9P267
AGLLFVVTRYLHSWP

GPR156

271

Q8NFN8
GSIHYFRVPREYWRD

GLB1L2

66

Q8IW92
LHERYGPVVSFWFGR

CYP20A1

61

Q6UW02
YDRAFPISHIRFWAL

GJA3

66

Q9Y6H8
LTEPPFRWRFYLHET

ERVFC1

26

P60507
GIRRWNYFFPEELLV

PRIMPOL

396

Q96LW4
YVLSVLWDGLPRHFI

FES

491

P07332
VHFYWVRGEEIIPRG

MRPS30

206

Q9NP92
WVPRKGLHLFAVFYT

SFT2D2

56

O95562
GDLIEIFRPFYRHWA

PLAAT3

11

P53816
IFRPFYRHWAIYVGD

PLAAT3

16

P53816
GPYLGVHLRRKDFIW

POFUT2

286

Q9Y2G5
GNIFYLFEPLWHIER

CHST3

156

Q7LGC8
APGFVYAWLELISHR

CNOT1

2031

A5YKK6
HPNLWIRYGAVGFIT

PIK3R4

666

Q99570
RGHAAPILYAAWVEV

TKTL2

76

Q9H0I9
RGEVWPFLLRYYSHE

TBC1D16

431

Q8TBP0
FGYEVWREFPDRLVG

EXT2

551

Q93063
FGTIHVPYTRVWDFI

TRABD2A

56

Q86V40
RDTHLWYFVIPGFSI

TMEM168

286

Q9H0V1
WQTHPFLRGIGYRIF

PKHD1L1

1426

Q86WI1
TEWRGPRVLYFGDHL

NT5DC2

346

Q9H857
LFIWAIRHPASGYVQ

TBC1D22A

306

Q8WUA7
HNIYVWDVRRPFVPA

WDR24

276

Q96S15
LWYHTVVRPFFALDG

TTC39C

276

Q8N584
DWHIAYVLLYGPRRV

USP14

471

P54578
LHSVWRLIPAFRGYA

USP44

406

Q9H0E7
YTEDEVLWGHRFFPV

KCNJ3

316

P48549
RDAGFRVTLWVHPFV

MYORG

381

Q6NSJ0