Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of translation at synapse, modulating synaptic transmission

FXR2 EIF4A3

6.83e-059292GO:0099547
GeneOntologyBiologicalProcessneuron development

RPGR KIDINS220 TENM4 GFAP HECW2 DISC1 GOLGA4 SRRM4 ARHGAP33

1.21e-041463299GO:0048666
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

TENM4 FXR2 GFAP DISC1 GOLGA4

1.22e-04354295GO:0050769
GeneOntologyBiologicalProcessregulation of translation at synapse

FXR2 EIF4A3

1.47e-0413292GO:0140243
GeneOntologyBiologicalProcessregulation of neuron projection development

KIDINS220 GFAP HECW2 DISC1 GOLGA4 ARHGAP33

1.77e-04612296GO:0010975
GeneOntologyBiologicalProcesspositive regulation of nervous system development

TENM4 FXR2 GFAP DISC1 GOLGA4

2.65e-04418295GO:0051962
DomainDOCK_C

DOCK2 DOCK6

1.18e-0411282IPR010703
DomainDHR-1_domain

DOCK2 DOCK6

1.18e-0411282IPR027007
DomainDHR_2

DOCK2 DOCK6

1.18e-0411282PS51651
DomainDHR_1

DOCK2 DOCK6

1.18e-0411282PS51650
DomainDOCK-C2

DOCK2 DOCK6

1.18e-0411282PF14429
DomainDHR-2

DOCK2 DOCK6

1.18e-0411282IPR027357
DomainDHR-2

DOCK2 DOCK6

1.18e-0411282PF06920
DomainDOCK

DOCK2 DOCK6

1.18e-0411282IPR026791
Domainzf-C2H2_jaz

ZNF638 HIVEP2

4.91e-0422282PF12171
DomainZnf_C2H2_jaz

ZNF638 HIVEP2

4.91e-0422282IPR022755
DomainAnk

KIDINS220 PPP1R27 PPP1R12C

4.70e-03228283PF00023
Domain-

KIDINS220 PPP1R27 PPP1R12C

5.93e-032482831.25.40.20
DomainANK

KIDINS220 PPP1R27 PPP1R12C

6.13e-03251283SM00248
DomainZnf_PHD-finger

KDM2A BAZ2B

6.22e-0379282IPR019787
DomainANK_REPEAT

KIDINS220 PPP1R27 PPP1R12C

6.27e-03253283PS50088
DomainAnkyrin_rpt-contain_dom

KIDINS220 PPP1R27 PPP1R12C

6.33e-03254283IPR020683
DomainANK_REP_REGION

KIDINS220 PPP1R27 PPP1R12C

6.33e-03254283PS50297
DomainAnkyrin_rpt

KIDINS220 PPP1R27 PPP1R12C

6.90e-03262283IPR002110
DomainSH3_2

DOCK2 ARHGAP33

7.33e-0386282IPR011511
DomainSH3_2

DOCK2 ARHGAP33

7.33e-0386282PF07653
DomainPHD

KDM2A BAZ2B

7.83e-0389282SM00249
DomainZnf_PHD

KDM2A BAZ2B

8.17e-0391282IPR001965
DomainZF_PHD_2

KDM2A BAZ2B

8.88e-0395282PS50016
DomainZF_PHD_1

KDM2A BAZ2B

9.06e-0396282PS01359
Pubmed

RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer.

SRRM3 SRRM4

7.19e-07230234312180
Pubmed

DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7.

GFAP DISC1

2.16e-06330227287808
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

ZNF638 KIDINS220 BCLAF1 EIF4A3 HECW2

6.77e-0631330538270169
Pubmed

Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.

GFAP DISC1

1.08e-05630220212127
Pubmed

Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.

GFAP DISC1

1.51e-05730215381924
Pubmed

Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors.

RPGR GFAP

1.51e-05730221212183
Pubmed

SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus.

GFAP DISC1

2.58e-05930238960088
Pubmed

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

GFAP DISC1

2.58e-05930219303846
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

KDM2A CDC25A BCLAF1 EIF4A3 HECW2 PPP1R27

3.24e-0573030634857952
Pubmed

A human MAP kinase interactome.

KDM2A CCDC97 HIVEP2 GFAP ARHGAP33

5.57e-0548630520936779
Pubmed

Gpr158 mediates osteocalcin's regulation of cognition.

GPR156 GFAP

6.50e-051430228851741
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK2 DOCK6

6.50e-051430212432077
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK6 BCLAF1 EIF4A3 HECW2 SRRM4

8.31e-0552930514621295
Pubmed

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.

DISC1 PPP1R12C

9.70e-051730222153077
Pubmed

Serological detection of cutaneous T-cell lymphoma-associated antigens.

ZNF638 GOLGA4

1.09e-041830211149944
Pubmed

Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.

SRRM3 SRRM4

1.09e-041830233087486
Pubmed

Interactome analysis of the human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein.

FXR2 BCLAF1 EIF4A3

2.29e-0413830330320910
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ZNF638 KDM2A BCLAF1 GOLGA4

2.50e-0436030433111431
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

ZNF638 BCLAF1 EIF4A3 PPP1R12C

2.53e-0436130430344098
Pubmed

TERRA transcripts are bound by a complex array of RNA-binding proteins.

FXR2 BCLAF1

2.68e-042830220975687
Pubmed

Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.

FXR2 GFAP

2.68e-042830233154347
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF638 KIDINS220 DOCK6 BCLAF1 EIF4A3 ARHGAP33

2.80e-04108230638697112
Pubmed

CRL4AMBRA1 is a master regulator of D-type cyclins.

KDM2A CDC25A

3.08e-043030233854235
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

TENM4 DOCK6 HECW2

3.11e-0415330310718198
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

ZNF638 FXR2 BCLAF1 EIF4A3 CLASRP

3.33e-0471330529802200
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

ZNF638 CCDC97 FXR2 EIF4A3

3.52e-0439430427248496
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

SRRM3 FXR2 EIF4A3 GOLGA4 SRRM4

3.55e-0472330534133714
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ZNF638 FXR2 BAZ2B BCLAF1

4.13e-0441130435182466
Pubmed

DNA Damage Regulates Translation through β-TRCP Targeting of CReP.

HIVEP2 CDC25A

4.20e-043530226091241
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

ZNF638 BCLAF1 EIF4A3

4.23e-0417030316159877
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ZNF638 RPGR KIDINS220 BCLAF1 GOLGA4

4.93e-0477730535844135
Pubmed

Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.

KDM2A FXR2

4.96e-043830223537643
Pubmed

Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.

KIDINS220 TENM4

5.23e-043930224095980
Pubmed

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.

HIVEP2 BAZ2B

6.06e-044230224997765
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

DOCK2 FXR2 CLASRP

6.49e-0419730320811636
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF638 KDM2A BAZ2B BCLAF1 EIF4A3 CLASRP

7.23e-04129430630804502
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

HIVEP2 DOCK6 DSTYK GOLGA4 PPP1R12C

7.83e-0486130536931259
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK2 KDM2A BAZ2B DSTYK

8.16e-0449330415368895
InteractionPRC1 interactions

DOCK2 ZNF638 CDC25A FXR2 BAZ2B BCLAF1 EIF4A3 ARHGAP33 PPP1R12C

7.84e-06973309int:PRC1
InteractionCIT interactions

ZNF638 KDM2A CDC25A FXR2 GFAP BCLAF1 EIF4A3 HECW2 DISC1 GOLGA4

2.85e-0514503010int:CIT
Cytoband17q25.3

EIF4A3 PPP1R27

2.00e-0310130217q25.3
Cytoband17p13.1

FXR2 SPEM1

2.72e-0311830217p13.1
CytobandEnsembl 112 genes in cytogenetic band chr19q13

CCDC97 ARHGAP33 PPP1R12C CLASRP

7.24e-031192304chr19q13
GeneFamilyAnkyrin repeat domain containing

KIDINS220 PPP1R27 PPP1R12C

9.57e-04242153403
GeneFamilyPHD finger proteins

KDM2A BAZ2B

2.47e-039015288
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R27 PPP1R12C

9.61e-03181152694
CoexpressionGSE39022_LN_VS_SPLEEN_DC_DN

HIVEP2 KIDINS220 BCLAF1 DSTYK

7.42e-05198304M9018
CoexpressionGSE28237_FOLLICULAR_VS_LATE_GC_BCELL_UP

ZNF638 DOCK6 BAZ2B DSTYK

7.57e-05199304M4886
CoexpressionGSE24574_BCL6_HIGH_TFH_VS_NAIVE_CD4_TCELL_DN

RPGR HIVEP2 BAZ2B EIF4A3

7.72e-05200304M8327
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

ZNF638 RPGR KIDINS220 BAZ2B BCLAF1 GOLGA4

8.54e-05656306M18979
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

KDM2A RPGR BCLAF1 GOLGA4

7.91e-061913041ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDM2A CACNG4 ARHGAP33

1.46e-04153303489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNG4 SRRM3 SRRM4

1.96e-0416930396a2aec9acf8a6f966973c035e5ade456cf47772
ToppCellnormal_Lung-Endothelial_cells-EPCs|normal_Lung / Location, Cell class and cell subclass

DOCK6 GFAP HECW2

2.21e-0417630371d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CDC25A SRRM3 GFAP

2.25e-04177303f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIDINS220 SRRM3 SRRM4

2.29e-04178303a9ba4089413b1c55d667ce836b6972ca572ee2b8
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIDINS220 SRRM3 SRRM4

2.29e-0417830313dfd28a80889c2dacdc65b94a41bb9762dc409d
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

DOCK2 TENM4 HECW2

2.32e-04179303cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 COLGALT2 HIVEP2

2.32e-0417930314fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 COLGALT2 HIVEP2

2.44e-041823037b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCellControl-APC-like|Control / group, cell type (main and fine annotations)

DOCK2 TENM4 DISC1

2.48e-04183303c313ac72cc9fa1583456d452393f61f0a4ca33a8
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF638 BCLAF1 GOLGA4

2.52e-041843031154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

RPGR DOCK6 HECW2

2.56e-0418530336ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

RPGR DOCK6 HECW2

2.56e-041853034a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNG4 HECW2 SPEM1

2.60e-04186303bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK6 NHSL2 HECW2

2.68e-041883030026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CDC25A NHSL2 HECW2

2.68e-041883035d166d9e71632edd059ff0a9f66f8763f259d40a
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

2.68e-04188303d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RPGR DOCK6 HECW2

2.77e-041903036e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNG4 SRRM3 SRRM4

2.77e-04190303bdbfaced785db79ff965f332759be258dbf743cf
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RPGR DOCK6 HECW2

2.77e-0419030306bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

RPGR DOCK6 HECW2

2.77e-041903039fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(general)|COVID-19 / group, cell type (main and fine annotations)

RPGR DOCK6 HECW2

2.77e-04190303812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCellwk_08-11-Epithelial-Proximal_epithelial-intermediate_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CACNG4 SRRM3 SRRM4

2.77e-041903035f1863bce9400b7c932f0e4d0e012ec4e8d7e555
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

2.77e-041903031caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellCOVID-19-kidney-Stressed_EC|kidney / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

2.81e-04191303d35aa842b813ea0eff7362abc894cca4e86b2fb2
ToppCellPBMC-Control-cDC_6|Control / Compartment, Disease Groups and Clusters

TENM4 BCLAF1 EIF4A3

2.85e-0419230341a7201febb7d88a39e4ee64df04cce18c691df8
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIDINS220 BAZ2B HECW2

2.90e-04193303aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK6 HECW2 DISC1

2.90e-04193303af5108260783e69a7d67896c5bf64f862525926d
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIDINS220 BAZ2B HECW2

2.90e-04193303c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP2 TENM4 SRRM3

2.90e-04193303be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP2 TENM4 SRRM3

2.90e-041933030c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP2 TENM4 SRRM3

2.90e-041933038689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BAZ2B DSTYK SRRM4

2.94e-04194303b111d10c99d7ff7eb261cd7786cd9d9a549049b1
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK6 BAZ2B HECW2

2.94e-041943030b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellnucseq-Endothelial-Endothelial_Vascular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPGR DOCK6 HECW2

3.03e-04196303686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCellCOVID-19-lung-Capillary_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

3.03e-04196303ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK6 NHSL2 HECW2

3.03e-04196303f0b106078212be1d0938f545707a004a1e830857
ToppCellCOVID-19-lung-Capillary_1|lung / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

3.08e-041973037e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPGR DOCK6 HECW2

3.08e-04197303ca6bce1a92c6326f41a6300c31da02386bafa152
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPGR DOCK6 HECW2

3.08e-04197303ebf9be068eaa658493fa7884fd19f34642922acb
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

KDM2A BCLAF1 GOLGA4

3.08e-041973035c33454b10023decd2f5ccda9229b6512659711e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SRRM3 SRRM4

3.08e-041973032d92b0483d57541aee382dda80e42cf66e813d6b
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RPGR DOCK6 HECW2

3.12e-04198303fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

KDM2A BCLAF1 GOLGA4

3.12e-0419830344417089b62056269cac38d3134ff209c05b7007
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

3.12e-0419830345419f2804b4be79bae6632e71c54e1af482d115
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KDM2A BCLAF1 GOLGA4

3.12e-0419830328ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HIVEP2 TENM4 SRRM3

3.12e-041983038ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_2|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SRRM3 SRRM4

3.12e-04198303b73b9feb82997b654718aa27f33ca7b454214802
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HIVEP2 SRRM3 SRRM4

3.12e-04198303c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SRRM3 HECW2 SRRM4

3.12e-041983030ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

KIDINS220 BAZ2B BCLAF1

3.12e-04198303de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RPGR DOCK6 HECW2

3.12e-04198303b3a020522e064bb61949d38e442f24026e339364
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK6 NHSL2 HECW2

3.17e-04199303da5a88749d859d535daa030d0974485906cc0ba7
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

RPGR DOCK6 HECW2

3.17e-04199303793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SRRM3 SRRM4

3.17e-041993035de2a32bc2e9c752eb19a013b1807949153728fc
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

RPGR BCLAF1 GOLGA4

3.17e-0419930361b1ed2db71b96157b92b7535d1955a4033098da
ToppCellParenchyma_COVID-19-Endothelial-TX-Lymphatic|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

RPGR DOCK6 HECW2

3.17e-0419930388f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

BAZ2B BCLAF1 GOLGA4

3.17e-04199303fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

BAZ2B BCLAF1 GOLGA4

3.17e-04199303c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellBronchial-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RPGR DOCK6 HECW2

3.17e-0419930336a230b80096455df26c2e2c8c05fd6b231508c5
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPGR DOCK6 HECW2

3.17e-0419930364b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SRRM3 SRRM4

3.17e-0419930377b4aa00f14b86ef5db0490be98787e063979541
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK6 NHSL2 HECW2

3.17e-04199303f0bf75bfae7b288ecb6801be458b03ebd0108ea7
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPGR DOCK6 HECW2

3.17e-041993032b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK6 NHSL2 HECW2

3.17e-041993038b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellNeuron-Postmitotic-Excitatory_Neuron_|World / Primary Cells by Cluster

HIVEP2 KIDINS220 SRRM4

3.17e-04199303058373b4ac3cec2108cb24265628ff0a50646e33
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

HIVEP2 KIDINS220 SRRM4

3.22e-0420030384e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal|10w / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SRRM3 SRRM4

3.22e-04200303979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCellParenchyma_COVID-19-Endothelial-TX-Capillary|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

RPGR DOCK6 HECW2

3.22e-042003036c0498a5868891e8e22c03469d00669b20249b1a
ToppCellParenchyma_COVID-19-Endothelial-TX-Endothelial-1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

RPGR DOCK6 HECW2

3.22e-04200303b65fb8d378abd91cdabf5faac5f4b90d527f8c44
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Capillary-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPGR DOCK6 HECW2

3.22e-042003037020045b933cb104fb99b79524cb0d4734b8636d
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

SRRM3 HECW2 SRRM4

3.22e-0420030348d801219bc771d6c7e151dc88ca4c179988de85
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPGR DOCK6 HECW2

3.22e-042003032cb6e35add34b9dc564ebcf5d3cbc761325ca9f4
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK6 NHSL2 HECW2

3.22e-0420030390061284a80d29a4ca6078f578e13d32b8cc80e1
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Capillary|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPGR DOCK6 HECW2

3.22e-04200303e9913511a129bb3cee85e7ebf565b951dab91542
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPGR DOCK6 HECW2

3.22e-04200303e9d5ba140cabae11c437012d519b85f5412dcc94
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

HIVEP2 KIDINS220 SRRM4

3.22e-04200303c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KDM2A BCLAF1 GOLGA4

3.22e-0420030312f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLung_Parenchyma-Severe-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPGR DOCK6 HECW2

3.22e-04200303d9d0ffa18e5b4647966e19ad9830cbba6120677e
ToppCellParenchyma_COVID-19-Endothelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

RPGR DOCK6 HECW2

3.22e-04200303abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SRRM3 SRRM4

3.22e-0420030368c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCellCOVID-19|World / Disease, condition lineage and cell class

KDM2A BCLAF1 GOLGA4

3.22e-042003037dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPGR DOCK6 HECW2

3.22e-0420030327507c4b41d45c7cc50e4993169c0302be22ee34
DrugCytisine (-) [485-35-8]; Down 200; 21uM; HL60; HG-U133A

KDM2A CACNG4 HIVEP2 BAZ2B DISC1

5.65e-061983051766_DN
DiseaseHeadache, glucose measurement

ZNF638 SRRM3

3.58e-059302EFO_0004468, HP_0002315
Diseaselean body mass

ZNF638 KDM2A COLGALT2 HIVEP2

5.64e-04379304EFO_0004995
Diseaseblood titanium measurement

BAZ2B HECW2

6.16e-0436302EFO_0021532
Diseasemajor depressive episode

TENM4 BAZ2B

1.05e-0347302EFO_0007634
Diseasecoronary artery disease

CCDC97 HIVEP2 CDC25A DOCK6 DSTYK SRRM4

1.12e-031194306EFO_0001645
Diseaseresponse to tenofovir

KIDINS220 CDC25A

1.24e-0351302EFO_0009279
DiseasePROSTATE CANCER, HEREDITARY, 1

DOCK2 KDM2A

1.71e-0360302C4722327
Diseaseplatelet-derived growth factor BB measurement

DOCK2 DSTYK

1.76e-0361302EFO_0008264
Diseaseschizophrenia (implicated_via_orthology)

HIVEP2 DISC1

2.18e-0368302DOID:5419 (implicated_via_orthology)
DiseaseProstate cancer, familial

DOCK2 KDM2A

2.25e-0369302C2931456
Diseasepreeclampsia

COLGALT2 TENM4

2.86e-0378302EFO_0000668
DiseaseDepression, Bipolar

TENM4 DISC1

2.93e-0379302C0005587

Protein segments in the cluster

PeptideGeneStartEntry
PDRQRAREESRMRRR

BAZ2B

851

Q9UIF8
RRRLARRPGYMRSST

DISC1

36

Q9NRI5
RRYQSIRRTMTNERP

HECW2

861

Q9P2P5
RDTYRRRQMQRTITR

KIDINS220

901

Q9ULH0
RRSRRRRTDEDRTVM

FXR2

546

P51116
QRLRRMERSLSSYRG

GOLGA4

141

Q13439
RVFDMIRRRSLRTRA

EIF4A3

166

P38919
RPRTLRTRLRNRRYA

CCDC97

146

Q96F63
MERRRITSAARRSYV

GFAP

1

P14136
SSTRRMESERSPLYR

DSTYK

291

Q6XUX3
TFMRSRPSRQRLRQR

ARHGAP33

291

O14559
ERIRYSQRLRGTMRR

KDM2A

6

Q9Y2K7
DDRRVGRPRSMLRSY

DOCK2

1626

Q92608
ARQEMVRRSRERSPF

DOCK6

1331

Q96HP0
ARMPSYRYRRRRSRS

CACNG4

231

Q9UBN1
RTYSRSRSRDRMYSR

BCLAF1

41

Q9NYF8
PYMVRRRRAAQRARS

GPR156

596

Q8NFN8
RRKDRRDRMLRTLYE

COLGALT2

351

Q8IYK4
ERGPRMCRYVRERDR

CDC25A

436

P30304
LSARMRRRERERSPD

RPGR

406

Q92834
RRRERERSPDSFSMR

RPGR

411

Q92834
RKRRRDSPSFMEPRR

SRRM3

561

A6NNA2
SRDRRRSYQMPVRDE

PPP1R12C

526

Q9BZL4
DSLYRRTVRLRRRLP

NHSL2

66

Q5HYW2
SSGRIVYDARDMRRR

SPEM1

256

Q8N4L4
MYSGRRSRRQRREFR

CLASRP

261

Q8N2M8
ARYARYSPRQRRRRM

PPP1R27

6

Q86WC6
YSPRQRRRRMLADRS

PPP1R27

11

Q86WC6
RRRRMLADRSVRFPN

PPP1R27

16

Q86WC6
ERARRRRRSYSPMRK

SRRM4

481

A7MD48
RRRSYSPMRKRRRDS

SRRM4

486

A7MD48
RKPYRSLTRRRDAER

TENM4

6

Q6N022
RRDLSPRRERRYMTT

HIVEP2

2126

P31629
PRRERRYMTTIRAPS

HIVEP2

2131

P31629
FRSVSPERMSRRSVR

ZNF638

556

Q14966