Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P PAN2 USP17L22 USP27X USP17L15	7.99e-16	114	159	16	GO:0004843
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 HINT1 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P PAN2 USP17L22 USP27X USP17L15	8.08e-16	137	159	17	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 HINT1 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 SCRN2 USP17L17 USP17L6P PAN2 USP17L22 USP27X CTSK USP17L15	1.08e-15	192	159	19	GO:0008234
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P PAN2 USP17L22 USP27X USP17L15	3.15e-15	124	159	16	GO:0101005
GeneOntologyMolecularFunction	peptidase activity	ADAMTS19 USP17L21 HINT1 USP22 USP17L12 ERAP1 USP17L20 PRSS12 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 SCRN2 DPP9 USP17L17 USP17L6P PAN2 USP17L22 USP27X CTSK USP17L15	2.31e-09	654	159	23	GO:0008233
GeneOntologyMolecularFunction	triacylglycerol lipase activity	PNLIPRP2 LIPF LIPG LPL	5.05e-05	26	159	4	GO:0004806
GeneOntologyMolecularFunction	IMP dehydrogenase activity	IMPDH1 IMPDH2	6.30e-05	2	159	2	GO:0003938
GeneOntologyMolecularFunction	coenzyme A binding	HMGCR ALAS2	1.88e-04	3	159	2	GO:0120225
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP12 LRP8 STAB1	2.57e-04	16	159	3	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP12 LRP8 STAB1	5.93e-04	21	159	3	GO:0030228
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM SI	6.20e-04	5	159	2	GO:0004558
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 HINT1 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP27X USP17L15	2.35e-14	144	160	16	GO:0070646
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP27X USP17L15	4.95e-14	125	160	15	GO:0016579
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L21 HINT1 USP22 USP17L12 MID2 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 PARP14 ZZEF1 USP17L18 AHRR RACK1 USP17L17 ANAPC1 KLHDC3 USP17L6P HERC6 USP17L22 USP27X USP17L15	2.86e-06	1074	160	24	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L21 HINT1 USP22 USP17L12 MID2 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 ZZEF1 USP17L18 AHRR RACK1 USP17L17 ANAPC1 KLHDC3 USP17L6P HERC6 USP17L22 USP27X USP17L15	3.40e-06	1009	160	23	GO:0070647
GeneOntologyBiologicalProcess	GMP salvage	IMPDH1 IMPDH2 ADA	5.28e-05	10	160	3	GO:0032263
GeneOntologyBiologicalProcess	galactolipid metabolic process	GALC PNLIPRP2 UGT8	5.28e-05	10	160	3	GO:0019374
GeneOntologyBiologicalProcess	ribonucleotide metabolic process	MYH4 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL DHODH CTNS KYNU	7.30e-05	533	160	14	GO:0009259
GeneOntologyBiologicalProcess	triglyceride catabolic process	PNLIPRP2 LIPG PIK3CG LPL	8.17e-05	30	160	4	GO:0019433
GeneOntologyBiologicalProcess	ribose phosphate metabolic process	MYH4 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL DHODH CTNS KYNU	8.38e-05	540	160	14	GO:0019693
GeneOntologyBiologicalProcess	nucleotide metabolic process	MYH4 NMNAT2 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL DHODH ENPP5 CTNS KYNU	8.69e-05	684	160	16	GO:0009117
GeneOntologyBiologicalProcess	nucleoside phosphate metabolic process	MYH4 NMNAT2 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL DHODH ENPP5 CTNS KYNU	9.78e-05	691	160	16	GO:0006753
GeneOntologyBiologicalProcess	purine ribonucleotide metabolic process	MYH4 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL CTNS KYNU	1.85e-04	512	160	13	GO:0009150
GeneOntologyBiologicalProcess	organophosphate metabolic process	MYH4 NMNAT2 HINT1 IMPDH1 IMPDH2 PNLIPRP2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL LIPG PIK3CG LPL DHODH ENPP5 SERAC1 CTNS KYNU	2.08e-04	1142	160	21	GO:0019637
GeneOntologyBiologicalProcess	ribonucleoside monophosphate biosynthetic process	IMPDH1 IMPDH2 ADA DHODH	2.10e-04	38	160	4	GO:0009156
GeneOntologyBiologicalProcess	GMP biosynthetic process	IMPDH1 IMPDH2 ADA	2.38e-04	16	160	3	GO:0006177
GeneOntologyBiologicalProcess	purine ribonucleotide salvage	IMPDH1 IMPDH2 ADA	2.38e-04	16	160	3	GO:0106380
GeneOntologyBiologicalProcess	neutral lipid catabolic process	PNLIPRP2 LIPG PIK3CG LPL	2.82e-04	41	160	4	GO:0046461
GeneOntologyBiologicalProcess	acylglycerol catabolic process	PNLIPRP2 LIPG PIK3CG LPL	2.82e-04	41	160	4	GO:0046464
GeneOntologyBiologicalProcess	nucleobase-containing small molecule metabolic process	MYH4 NMNAT2 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL DHODH ENPP5 CTNS KYNU	3.18e-04	767	160	16	GO:0055086
GeneOntologyBiologicalProcess	purine nucleotide metabolic process	MYH4 NMNAT2 HINT1 IMPDH1 IMPDH2 GCDH HMGCR PFKL SLC25A16 ADA CS BPHL CTNS KYNU	3.42e-04	619	160	14	GO:0006163
GeneOntologyBiologicalProcess	disaccharide catabolic process	MGAM SI	3.55e-04	4	160	2	GO:0046352
GeneOntologyBiologicalProcess	galactolipid catabolic process	GALC PNLIPRP2	3.55e-04	4	160	2	GO:0019376
Domain	HABP4_PAI-RBP1	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22	1.15e-17	16	159	10	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22	1.15e-17	16	159	10	IPR006861
Domain	UCH	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 PAN2 USP17L22 USP27X	9.31e-16	71	159	14	PF00443
Domain	USP_3	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 PAN2 USP17L22 USP27X	1.15e-15	72	159	14	PS50235
Domain	USP_dom	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 PAN2 USP17L22 USP27X	1.15e-15	72	159	14	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 PAN2 USP17L22 USP27X	1.15e-15	72	159	14	IPR001394
Domain	USP_CS	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP27X	1.04e-14	66	159	13	IPR018200
Domain	USP_1	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP27X	2.34e-14	70	159	13	PS00972
Domain	USP_2	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP27X	2.85e-14	71	159	13	PS00973
Domain	-	SEMA4B CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 PAN2 WDR86 PLXNA2	1.02e-06	333	159	14	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA4B CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 PAN2 WDR86 PLXNA2	1.10e-06	335	159	14	IPR015943
Domain	LIPASE_SER	PNLIPRP2 LIPF BPHL LIPG LPL	2.39e-06	26	159	5	PS00120
Domain	-	PNLIPRP2 ESD LIPF DPP9 BPHL LIPG LPL SERAC1	8.15e-06	119	159	8	3.40.50.1820
Domain	AB_hydrolase	PNLIPRP2 ESD LIPF DPP9 BPHL LIPG LPL SERAC1	8.15e-06	119	159	8	IPR029058
Domain	WD40_repeat_dom	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 PAN2 WDR86	9.32e-06	297	159	12	IPR017986
Domain	WD40	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 WDR86	1.40e-05	259	159	11	PF00400
Domain	WD40	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 WDR86	1.92e-05	268	159	11	SM00320
Domain	WD40_repeat	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 WDR86	2.20e-05	272	159	11	IPR001680
Domain	WD_REPEATS_1	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 WDR86	2.69e-05	278	159	11	PS00678
Domain	WD_REPEATS_2	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 WDR86	2.78e-05	279	159	11	PS50082
Domain	WD_REPEATS_REGION	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 ZNF106 EML5 RACK1 CFAP52 WDR86	2.78e-05	279	159	11	PS50294
Domain	Lipase/vitellogenin	PNLIPRP2 LIPG LPL	6.95e-05	10	159	3	IPR013818
Domain	TAG_lipase	PNLIPRP2 LIPG LPL	6.95e-05	10	159	3	IPR000734
Domain	Lipase	PNLIPRP2 LIPG LPL	6.95e-05	10	159	3	PF00151
Domain	Lipase_N	PNLIPRP2 LIPG LPL	6.95e-05	10	159	3	IPR033906
Domain	Lipase_LIPH	PNLIPRP2 LIPG LPL	6.95e-05	10	159	3	IPR016272
Domain	Lipo_Lipase	LIPG LPL	7.20e-05	2	159	2	IPR002330
Domain	LC_transporter	MPDU1 CTNS	7.20e-05	2	159	2	IPR005282
Domain	IMP_DH	IMPDH1 IMPDH2	7.20e-05	2	159	2	IPR005990
Domain	EGF_LAM_2	HSPG2 STAB1 CELSR3 ATRNL1	1.17e-04	30	159	4	PS50027
Domain	EGF_LAM_1	HSPG2 STAB1 CELSR3 ATRNL1	1.17e-04	30	159	4	PS01248
Domain	SSD	NPC1 HMGCR PTCHD1	1.63e-04	13	159	3	IPR000731
Domain	SSD	NPC1 HMGCR PTCHD1	1.63e-04	13	159	3	PS50156
Domain	EGF_Lam	HSPG2 STAB1 CELSR3 ATRNL1	2.16e-04	35	159	4	SM00180
Domain	Laminin_EGF	HSPG2 STAB1 CELSR3 ATRNL1	2.98e-04	38	159	4	IPR002049
Domain	NIPSNAP	NIPSNAP3B NIPSNAP3A	4.27e-04	4	159	2	IPR012577
Domain	IMPDH	IMPDH1 IMPDH2	4.27e-04	4	159	2	PF00478
Domain	Glyco_hydro_31_CS	MGAM SI	4.27e-04	4	159	2	IPR030459
Domain	IMP_DH_GMPRt	IMPDH1 IMPDH2	4.27e-04	4	159	2	IPR001093
Domain	Gal_mutarotase_N	MGAM SI	4.27e-04	4	159	2	IPR031727
Domain	IMP_DH_GMP_RED	IMPDH1 IMPDH2	4.27e-04	4	159	2	PS00487
Domain	IMP_DH/GMP_Rdtase_CS	IMPDH1 IMPDH2	4.27e-04	4	159	2	IPR015875
Domain	NtCtMGAM_N	MGAM SI	4.27e-04	4	159	2	PF16863
Domain	NIPSNAP	NIPSNAP3B NIPSNAP3A	4.27e-04	4	159	2	PF07978
Domain	-	IMPDH1 IMPDH2 DUS2 DHODH	4.40e-04	42	159	4	3.20.20.70
Domain	LH2	PNLIPRP2 LIPG LPL	4.50e-04	18	159	3	SM00308
Domain	WD40_repeat_CS	CHAF1B NWD1 COPA EML5 RACK1 CFAP52 WDR86	5.17e-04	164	159	7	IPR019775
Domain	Aldolase_TIM	IMPDH1 IMPDH2 DUS2 DHODH	5.27e-04	44	159	4	IPR013785
Domain	Apc4_WD40_dom	NWD1 COPA EML5	6.21e-04	20	159	3	IPR024977
Domain	ANAPC4_WD40	NWD1 COPA EML5	6.21e-04	20	159	3	PF12894
Domain	EGF_CA	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3	6.21e-04	122	159	6	SM00179
Domain	EGF-like_Ca-bd_dom	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3	6.77e-04	124	159	6	IPR001881
Domain	PQ-loop	MPDU1 CTNS	7.08e-04	5	159	2	PF04193
Domain	GLYCOSYL_HYDROL_F31_2	MGAM SI	7.08e-04	5	159	2	PS00707
Domain	Sterol-sensing	NPC1 HMGCR	7.08e-04	5	159	2	PF12349
Domain	CTNS	MPDU1 CTNS	7.08e-04	5	159	2	SM00679
Domain	PQ-loop_rpt	MPDU1 CTNS	7.08e-04	5	159	2	IPR006603
Domain	-	PNLIPRP2 LIPG LPL	7.19e-04	21	159	3	2.60.60.20
Domain	PLAT	PNLIPRP2 LIPG LPL	7.19e-04	21	159	3	PF01477
Domain	PLAT/LH2_dom	PNLIPRP2 LIPG LPL	7.19e-04	21	159	3	IPR001024
Domain	PLAT	PNLIPRP2 LIPG LPL	7.19e-04	21	159	3	PS50095
Domain	EGF	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3	7.36e-04	126	159	6	PF00008
Domain	EGF	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3 ATRNL1 TENM1	9.27e-04	235	159	8	SM00181
Domain	EGF_3	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3 ATRNL1 TENM1	9.27e-04	235	159	8	PS50026
Domain	-	LRP12 CUBN ZZEF1 ATRNL1	9.96e-04	52	159	4	2.60.120.290
Domain	PQQ	ZNF106 WDR86	1.06e-03	6	159	2	SM00564
Domain	Glyco_hydro_31_AS	MGAM SI	1.06e-03	6	159	2	IPR030458
Domain	PQQ_beta_propeller_repeat	ZNF106 WDR86	1.06e-03	6	159	2	IPR018391
Domain	Kelch-typ_b-propeller	KLHDC3 ATRNL1 KLHL23 KLHDC8B	1.23e-03	55	159	4	IPR015915
Domain	EGF-like_dom	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3 ATRNL1 TENM1	1.34e-03	249	159	8	IPR000742
Domain	CUB_dom	LRP12 CUBN ZZEF1 ATRNL1	1.41e-03	57	159	4	IPR000859
Domain	Dimeric_a/b-barrel	NIPSNAP3B NIPSNAP3A	1.47e-03	7	159	2	IPR011008
Domain	Glyco_hydro_31	MGAM SI	1.47e-03	7	159	2	IPR000322
Domain	Glyco_hydro_31	MGAM SI	1.47e-03	7	159	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM SI	1.47e-03	7	159	2	PS00129
Domain	EGF_1	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3 ATRNL1 TENM1	1.56e-03	255	159	8	PS00022
Domain	EGF-like_CS	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3 ATRNL1 TENM1	1.81e-03	261	159	8	IPR013032
Domain	P_TREFOIL_1	MGAM SI	1.95e-03	8	159	2	PS00025
Domain	Trefoil	MGAM SI	1.95e-03	8	159	2	PF00088
Domain	P_trefoil_CS	MGAM SI	1.95e-03	8	159	2	IPR017957
Domain	EGF_2	HSPG2 CUBN LRP8 STAB1 FAT1 CELSR3 ATRNL1 TENM1	1.99e-03	265	159	8	PS01186
Domain	Acyl-CoA_DH_CS	ACADL GCDH	2.49e-03	9	159	2	IPR006089
Domain	P_TREFOIL_2	MGAM SI	2.49e-03	9	159	2	PS51448
Domain	Ptc/Disp	NPC1 PTCHD1	2.49e-03	9	159	2	IPR003392
Domain	Patched	NPC1 PTCHD1	2.49e-03	9	159	2	PF02460
Domain	PD	MGAM SI	2.49e-03	9	159	2	SM00018
Domain	Plexin_repeat	SEMA4B ATRNL1 PLXNA2	2.51e-03	32	159	3	IPR002165
Domain	PSI	SEMA4B ATRNL1 PLXNA2	2.51e-03	32	159	3	PF01437
Domain	Kelch_1	KLHDC3 ATRNL1 KLHL23 KLHDC8B	3.00e-03	70	159	4	PF01344
Domain	Kelch_1	KLHDC3 ATRNL1 KLHL23 KLHDC8B	3.00e-03	70	159	4	IPR006652
Domain	ACYL_COA_DH_1	ACADL GCDH	3.10e-03	10	159	2	PS00072
Domain	ACYL_COA_DH_2	ACADL GCDH	3.10e-03	10	159	2	PS00073
Domain	Laminin_EGF	HSPG2 STAB1 CELSR3	3.24e-03	35	159	3	PF00053
Domain	-	MGAM SI	3.77e-03	11	159	2	4.10.110.10
Domain	Acyl-CoA_dh_N	ACADL GCDH	3.77e-03	11	159	2	PF02771
Domain	LAM_G_DOMAIN	HSPG2 FAT1 CELSR3	4.11e-03	38	159	3	PS50025
Domain	EGF_dom	CUBN STAB1	4.49e-03	12	159	2	IPR024731
Domain	P_trefoil_dom	MGAM SI	4.49e-03	12	159	2	IPR000519
Domain	EGF_3	CUBN STAB1	4.49e-03	12	159	2	PF12947
Domain	LDLR_class-A_CS	HSPG2 LRP12 LRP8	4.75e-03	40	159	3	IPR023415
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.81e-15	45	124	12	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.27e-08	191	124	13	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15	7.19e-08	221	124	13	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	5.14e-07	262	124	13	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP22 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15	2.26e-06	299	124	13	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.35e-05	318	124	12	MM15278
Pathway	REACTOME_DIGESTION	MGAM PNLIPRP2 LIPF SI	3.04e-05	21	124	4	MM15526
Pathway	REACTOME_DIGESTION	MGAM PNLIPRP2 LIPF SI	4.44e-05	23	124	4	M27790
Pathway	REACTOME_DIGESTION_AND_ABSORPTION	MGAM PNLIPRP2 LIPF SI	6.25e-05	25	124	4	MM15557
Pathway	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	HSPG2 LRP12 NMNAT2 CUBN PARP14 SLC25A16 COQ2 LRP8 LPL	6.26e-05	198	124	9	M18311
Pathway	REACTOME_DIGESTION_AND_ABSORPTION	MGAM PNLIPRP2 LIPF SI	9.92e-05	28	124	4	M27837
Pathway	WP_FATTY_ACID_BETAOXIDATION	ACADL LIPF GCDH LPL	2.16e-04	34	124	4	M39596
Pathway	WP_FATTY_ACID_BETAOXIDATION	ACADL LIPF GCDH LPL	2.16e-04	34	124	4	MM15937
Pathway	REACTOME_NUCLEOTIDE_BIOSYNTHESIS	IMPDH1 IMPDH2 DHODH	2.25e-04	14	124	3	MM15551
Pathway	REACTOME_NUCLEOTIDE_BIOSYNTHESIS	IMPDH1 IMPDH2 DHODH	2.25e-04	14	124	3	M27830
Pathway	REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE	NPC1 A2M CUBN LIPG LPL	5.13e-04	75	124	5	M27032
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.81e-23	21	161	12	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.81e-23	21	161	12	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.81e-23	21	161	12	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.81e-23	21	161	12	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.81e-23	21	161	12	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.81e-23	21	161	12	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	3.96e-23	22	161	12	9154835
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.45e-22	33	161	13	20228807
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.64e-22	24	161	12	8995226
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	20403174
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	14699124
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	11941478
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	20388806
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	20368735
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	2.33e-22	34	161	13	21448158
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	3.15e-22	25	161	12	21115691
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	3.70e-22	35	161	13	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	3.70e-22	35	161	13	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	5.76e-22	36	161	13	20147298
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	5.82e-22	26	161	12	35816173
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	8.85e-22	37	161	13	20228808
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	3.09e-21	29	161	12	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	6.66e-18	50	161	12	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L21 ANK1 USP17L12 MID2 USP17L20 USP17L11 CEACAM7 USP17L5 STYXL2 USP17L10 USP17L19 USP17L18 USP17L17 KLHL23 USP17L6P USP17L22 USP17L15	1.82e-08	674	161	17	37196079
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TTC28 ERAP1 RALGAPB ALS2 ADGRV1 STAB1 PASK SYNE2 ERC2	1.15e-06	225	161	9	12168954
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	NPC1 HSPG2 FLNA HINT1 MID2 ESD NOX3 ADGRV1 PFKL CUBN CEMIP2 TIAM2 SCRN2 VPS13D FAT1 EML5 RACK1 CTNS	1.26e-06	1016	161	18	19056867
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 USP17L18 USP17L17	1.45e-06	119	161	7	28625976
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	NPC1 FLNA ABCC4 ZNF573 PNLIPRP2 SLC39A9 ERAP1 MPDU1 LIPF ZNF571 NIPSNAP3A ALS2 CUBN TIAM2 AIFM2 FAT1 UGT8 ALAS2 SEC23B ZNF345	2.49e-06	1293	161	20	15342556
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NPC1 HSPG2 SEMA4B LRP12 ABCC4 COPA ERAP1 RECQL HMGCR NECTIN3 MAGT1 ZZEF1 CEMIP2 LRP8 IGSF10 FAT1 CELSR3 LPL UGT8	3.28e-06	1201	161	19	35696571
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	HSPG2 FLNA RPL30 SEMA4B GALC ACADL COPA SLC39A9 NIPSNAP3B ERAP1 SPEG NIPSNAP3A PFKL MAGT1 ZDHHC17 FAT1 CS DPP9 RACK1 TRAPPC9 SEC23B	3.86e-06	1451	161	21	30550785
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNA MYH4 IMPDH2 COPA FRYL PARP14 ANAPC1 CNOT1	4.95e-06	202	161	8	33005030
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MYH4 USP22 ANK1 USP17L12 SLC26A9 ZNF226 PFKL PARP14 SLC25A16 ZZEF1 QRICH2 IGSF10 PCDH10 CNOT1	9.22e-06	736	161	14	29676528
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	A2M RPL30 IMPDH2 TTC28 RALGAPB PFKL ZDHHC17 ZZEF1 CEMIP2 AIFM2 LPL KYNU SEC23B	1.15e-05	650	161	13	38777146
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	LIPF HMGCR PFKL LIPG PIK3CG LPL	1.83e-05	117	161	6	18996102
Pubmed	Expression of IMPDH mRNA after mycophenolate administration in male volunteers.	IMPDH1 IMPDH2	2.13e-05	2	161	2	25105143
Pubmed	Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms.	LIPG LPL	2.13e-05	2	161	2	19780863
Pubmed	Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.	IMPDH1 IMPDH2	2.13e-05	2	161	2	20718729
Pubmed	Two distinct cDNAs for human IMP dehydrogenase.	IMPDH1 IMPDH2	2.13e-05	2	161	2	1969416
Pubmed	Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion.	LIPG LPL	2.13e-05	2	161	2	17093291
Pubmed	Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies.	LIPG LPL	2.13e-05	2	161	2	17356047
Pubmed	Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.	IMPDH1 IMPDH2	2.13e-05	2	161	2	12944494
Pubmed	Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1.	NIPSNAP3B NIPSNAP3A	2.13e-05	2	161	2	15177564
Pubmed	PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.	ITGA4 PIK3CG	2.13e-05	2	161	2	28963139
Pubmed	Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.	IMPDH1 IMPDH2	2.13e-05	2	161	2	2902093
Pubmed	Characterization of human type I and type II IMP dehydrogenases.	IMPDH1 IMPDH2	2.13e-05	2	161	2	7903306
Pubmed	Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.	IMPDH1 IMPDH2	2.13e-05	2	161	2	7763314
Pubmed	Expanding the genetic and phenotypic spectrum of TRAPPC9 and MID2-related neurodevelopmental disabilities: report of two novel mutations, 3D-modelling, and molecular docking studies.	MID2 TRAPPC9	2.13e-05	2	161	2	38467738
Pubmed	Interaction between the α-glucosidases, sucrase-isomaltase and maltase-glucoamylase, in human intestinal brush border membranes and its potential impact on disaccharide digestion.	MGAM SI	2.13e-05	2	161	2	36968271
Pubmed	Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.	IMPDH1 IMPDH2	2.13e-05	2	161	2	14766016
Pubmed	Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue.	LIPG LPL	2.13e-05	2	161	2	15630456
Pubmed	Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.	NOX3 TIAM2	2.13e-05	2	161	2	15014044
Pubmed	Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.	IMPDH1 IMPDH2	2.13e-05	2	161	2	7896827
Pubmed	Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.	IMPDH1 IMPDH2	2.13e-05	2	161	2	20679962
Pubmed	Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation.	IMPDH1 IMPDH2	2.13e-05	2	161	2	17713475
Pubmed	Contribution of the Individual Small Intestinal α-Glucosidases to Digestion of Unusual α-Linked Glycemic Disaccharides.	MGAM SI	2.13e-05	2	161	2	27480812
Pubmed	Mutants of purine metabolism in cultured mouse and hamster cells.	IMPDH1 IMPDH2	2.13e-05	2	161	2	988789
Pubmed	Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.	MGAM SI	2.13e-05	2	161	2	20356844
Pubmed	LRP12 is an endogenous transmembrane inactivator of α4 integrins.	LRP12 ITGA4	2.13e-05	2	161	2	37330909
Pubmed	Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1.	ITGA4 AOC3	2.13e-05	2	161	2	16111634
Pubmed	Biochemistry and neuropathology of mice doubly deficient in synthesis and degradation of galactosylceramide.	GALC UGT8	2.13e-05	2	161	2	10650875
Pubmed	Twitcher mice with only a single active galactosylceramide synthase gene exhibit clearly detectable but therapeutically minor phenotypic improvements.	GALC UGT8	2.13e-05	2	161	2	10650876
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TTC28 SPEG KHNYN PPM1E RALGAPB ALS2 ZDHHC17 ERC2 PCDH10 PLXNA2	2.18e-05	407	161	10	12693553
Pubmed	The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.	HINT1 RACK1 TENM1	2.69e-05	13	161	3	25648896
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	GALC ACADL NIPSNAP3B BAK1 NIPSNAP3A GCDH TST SLC25A16 COQ2 DUS2 AIFM2 CS BPHL DHODH KYNU	2.87e-05	926	161	15	20877624
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	GALC ACADL NIPSNAP3B BAK1 NIPSNAP3A GCDH TST SLC25A16 COQ2 DUS2 AIFM2 CS BPHL DHODH ALAS2 KYNU	3.11e-05	1047	161	16	18614015
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP22 USP17L6P PAN2 USP27X USP17L15	3.85e-05	81	161	5	12838346
Pubmed	Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.	NPC1 CUBN LIPG LPL	3.92e-05	41	161	4	19878569
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NPC1 FLNA STARD8 ALS2 FRYL PFKL CUBN ZDHHC17 TIAM2 EML5 RACK1 KLHDC3 ATRNL1 PAN2 CNOT1 PHACTR1	4.69e-05	1084	161	16	11544199
Pubmed	Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.	HMGCR LIPG LPL	5.22e-05	16	161	3	20691829
Pubmed	USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.	A2M RPL30 HINT1 RACK1	5.68e-05	45	161	4	35605301
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 HSPG2 FLNA SEMA4B ARHGEF19 ARSJ IMPDH1 SPEG KHNYN FRYL ZZEF1 TIAM2 FAT1 CELSR3 ZNF335 TRAPPC9	5.88e-05	1105	161	16	35748872
Pubmed	Partial characterization of murine intestinal maltase-glucoamylase.	MGAM SI	6.37e-05	3	161	2	12150962
Pubmed	Localization of mRNA for UDP-galactose: ceramide galactosyltransferase in the brain during mouse development.	GALC UGT8	6.37e-05	3	161	2	8911769
Pubmed	T cell activation triggers reversible inosine-5'-monophosphate dehydrogenase assembly.	IMPDH1 IMPDH2	6.37e-05	3	161	2	30154209
Pubmed	Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors.	LIPG LPL	6.37e-05	3	161	2	23991054
Pubmed	PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.	ITGA4 PIK3CG	6.37e-05	3	161	2	23565202
Pubmed	Higher order lipase gene association with plasma triglycerides.	LIPG LPL	6.37e-05	3	161	2	15961789
Pubmed	Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity.	LIPG LPL	6.37e-05	3	161	2	24458708
Pubmed	Characterization of the lipolytic activity of endothelial lipase.	LIPG LPL	6.37e-05	3	161	2	12032167
Pubmed	c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.	IMPDH1 IMPDH2	6.37e-05	3	161	2	36629054
Pubmed	Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.	IMPDH1 IMPDH2	6.37e-05	3	161	2	20061166
Pubmed	RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic fibrosis transmembrane conductance regulator.	FLNA RACK1	6.37e-05	3	161	2	23636454
Pubmed	Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis.	FLNA COPA	6.37e-05	3	161	2	29592874
Pubmed	Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis.	TST RACK1	6.37e-05	3	161	2	20099848
Pubmed	The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.	ACADL PFKL	6.37e-05	3	161	2	36810848
Pubmed	Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.	ITGA4 PIK3CG	6.37e-05	3	161	2	21665146
Pubmed	Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein.	A2M LPL	6.37e-05	3	161	2	8662686
Pubmed	Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.	STAB1 AOC3	6.37e-05	3	161	2	17006978
Pubmed	Genome-wide association with bone mass and geometry in the Framingham Heart Study.	ADGRV1 ERC2 PHACTR1	8.93e-05	19	161	3	17903296
Pubmed	Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.	HMGCR LIPG LPL	8.93e-05	19	161	3	19148283
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	PPM1E BAK1 LIPG	1.05e-04	20	161	3	23666239
Pubmed	Defining the membrane proteome of NK cells.	NPC1 FLNA RPL30 ABCC4 IMPDH2 COPA ERAP1 MPDU1 RECQL PFKL MAGT1 ITGA4 PARP14 LRP8 PIK3CG CNOT1	1.12e-04	1168	161	16	19946888
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	SEMA4B SPEG CEACAM7 HEPACAM2 NECTIN3 IGSF10	1.13e-04	162	161	6	25826454
Pubmed	Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes.	LIPF LPL	1.27e-04	4	161	2	18681781
Cytoband	4p16.1	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.74e-18	79	162	13	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P TMEM271 USP17L22 USP17L15	7.43e-14	222	162	14	chr4p16
Cytoband	Ensembl 112 genes in cytogenetic band chr4q26	SYNPO2 ARSJ PRSS12 UGT8	4.43e-05	55	162	4	chr4q26
Cytoband	19q13.12	ZNF573 NFKBID ZNF571 ZNF345	1.27e-04	72	162	4	19q13.12
Cytoband	4q26	SYNPO2 ARSJ UGT8	5.14e-04	44	162	3	4q26
GeneFamily	WD repeat domain containing	CHAF1B NWD1 DYNC2I2 COPA WDR54 DCAF12L2 EML5 RACK1 CFAP52 WDR86	1.57e-06	262	98	10	362
GeneFamily	Lipases\|Arylacetamide deacetylase family	PNLIPRP2 LIPF LIPG LPL	5.51e-06	22	98	4	464
GeneFamily	Acyl-CoA dehydrogenase family	ACADL GCDH	1.55e-03	11	98	2	974
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 SPEG HEPACAM2 NECTIN3 IGSF10	1.84e-03	161	98	5	593
GeneFamily	Low density lipoprotein receptors	LRP12 LRP8	2.18e-03	13	98	2	634
GeneFamily	Ubiquitin specific peptidases	USP22 PAN2 USP27X	3.48e-03	56	98	3	366
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.83e-13	86	160	12	MM1312
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 HMGCR USP17L19 USP17L18 USP17L17 LPL USP17L6P USP17L22 USP17L15	1.20e-12	160	160	14	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	4.60e-12	112	160	12	MM1095
Coexpression	BRUINS_UVC_RESPONSE_LATE	NPC1 USP17L21 CHAF1B USP17L12 ERAP1 USP17L20 USP17L11 ESD USP17L5 ALS2 USP17L10 USP17L19 NECTIN3 WDR54 SLC25A16 TIAM2 USP17L18 AIFM2 CELSR3 USP17L17 USP17L6P HERC6 USP17L22 USP17L15	2.96e-07	1198	160	24	MM1062
Coexpression	GSE43260_BTLA_POS_VS_NEG_INTRATUMORAL_CD8_TCELL_DN	IMPDH2 ESD RECQL COQ2 ADA CS RACK1 KLHDC3	3.19e-05	199	160	8	M9954
Coexpression	GSE21546_WT_VS_SAP1A_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP	ARHGEF19 ATP8B4 RHOJ HEPACAM2 NECTIN3 SLC25A16 CELSR3 NKG7	3.31e-05	200	160	8	M7519
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	MXD3 USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 ALS2 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	4.56e-05	647	160	14	MM981
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M MGAM ANK1 ABCA13 ADGRV1 FAT1 TENM1 PCDH10 UNC79	1.77e-08	184	155	9	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M MGAM ANK1 ABCA13 ADGRV1 FAT1 TENM1 PCDH10 UNC79	1.77e-08	184	155	9	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M MGAM ANK1 ABCA13 ADGRV1 FAT1 TENM1 PCDH10 UNC79	1.77e-08	184	155	9	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells-Low_Quality-14\|World / Primary Cells by Cluster	TCAF2 RPL30 HINT1 TTC28 LRP8 RACK1 SYNE2 PLXNA2 RBFOX2	2.33e-08	190	155	9	feadd834d843f952aa7ced93899fd1f0868743df
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells-Low_Quality\|World / Primary Cells by Cluster	TCAF2 RPL30 HINT1 TTC28 LRP8 RACK1 SYNE2 PLXNA2 RBFOX2	2.33e-08	190	155	9	31cf1367db5c04242621f7c98a10d094bc519e31
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells\|World / Primary Cells by Cluster	TCAF2 RPL30 HINT1 TTC28 LRP8 RACK1 SYNE2 PLXNA2 RBFOX2	2.33e-08	190	155	9	f0b82334375749d917e440c493f10340c52ea13c
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	A2M ABCC4 ATP8B4 FRYL HMGCR ITGA4 ZDHHC17 PARP14 CEMIP2	2.44e-08	191	155	9	9454f642c3621370fa23640b631301346b300950
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ABCC4 ITGA4 FAT1 ATRNL1 LPL ERC2 WDR86	2.77e-07	184	155	8	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CHAF1B SLC26A9 ADGRV1 ADA CNTF	2.72e-06	63	155	5	83e1c91f830aadaf13e13254ce30189fd434bcc9
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CHAF1B SLC26A9 ADGRV1 ADA CNTF	2.72e-06	63	155	5	f2532b1aa117eea550f0ae0b599780c4fe621407
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CHAF1B SLC26A9 ADGRV1 ADA CNTF	2.72e-06	63	155	5	71c3afda6534401320791b714e3e2fe83094c914
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CHAF1B SLC26A9 ADGRV1 ADA CNTF	2.72e-06	63	155	5	0643435edf3280daf38c950e5bec287a9d5cb517
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS19 SYNPO2 ARSJ RHOJ CEMIP2 LRP8 TENM1	2.95e-06	177	155	7	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 FAT1 LIPG ATRNL1 LPL ERC2 WDR86	3.81e-06	184	155	7	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NPC1 A2M ABCC4 ATP8B4 FRYL HMGCR ITGA4	3.95e-06	185	155	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	mild-unassigned\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARHGEF19 ESD PFKL TST PASK ENPP5 PHACTR1	4.09e-06	186	155	7	5b2e1a58916f392fa1156bf9210df528775248ff
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	A2M ABCC4 FRYL PARP14 SNCAIP SYNE2 PLXNA2	4.24e-06	187	155	7	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SYNPO2 SPEG PPM1E KLHL23 AOC3 KLHDC8B	4.87e-06	191	155	7	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SYNPO2 SPEG PPM1E KLHL23 AOC3 KLHDC8B	4.87e-06	191	155	7	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 SYNPO2 SPEG FAT1 LIPG KLHL23 AOC3	5.04e-06	192	155	7	2cc712186e37fb21a964c032765c36a8b4a852cf
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STARD8 ARSJ TTC28 RHOJ CEMIP2 STAB1	5.22e-06	193	155	7	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STARD8 ARSJ TTC28 RHOJ CEMIP2 STAB1	5.22e-06	193	155	7	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STARD8 TTC28 RHOJ CEMIP2 STAB1 PLXNA2	5.22e-06	193	155	7	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M TCAF2 HSPG2 STARD8 RHOJ CEMIP2 LIPG	5.22e-06	193	155	7	682ce63b73a7d02eef240673db67058d7507f744
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M TCAF2 HSPG2 STARD8 RHOJ CEMIP2 LIPG	5.22e-06	193	155	7	c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FLNA SYNPO2 SPEG ITGA4 FAT1 ATRNL1 KLHL23	5.22e-06	193	155	7	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPC1 ABCC4 ACADL SLC26A9 ADGRV1 CATSPERB PHACTR1	5.40e-06	194	155	7	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SYNPO2 SPEG PPM1E KLHL23 AOC3 KLHDC8B	5.40e-06	194	155	7	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M TCAF2 HSPG2 STARD8 RHOJ CEMIP2 LIPG	5.58e-06	195	155	7	53b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	TTC28 LRP8 SNCAIP RACK1 CBFA2T2 SYNE2 PLXNA2	5.77e-06	196	155	7	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	TTC28 LRP8 SNCAIP RACK1 CBFA2T2 SYNE2 PLXNA2	5.77e-06	196	155	7	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn\|World / Primary Cells by Cluster	RPL30 TTC28 PRSS12 TIAM2 LRP8 PLXNA2 RBFOX2	5.77e-06	196	155	7	9401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M FLNA ADA CEMIP2 SYNE2 TENM1 NKG7	5.97e-06	197	155	7	8e41e6cda38eace961cb1a56f4df24468c66b956
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	ATP8B4 ABCA13 QRICH2 IGSF10 TENM1 ALAS2	1.39e-05	149	155	6	e9974260a5f2999b363f306cae005698c912893a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SYNPO2 PRSS12 SLC26A9 NOX3 KYNU	1.67e-05	91	155	5	3f56358ff0dacdf6b8fc22cea64082231bceb851
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	FLNA NIPSNAP3B SPEG SNCAIP AOC3 CNOT1	1.67e-05	154	155	6	423f58fc7dcef068458cbf7b4ee989e37227041e
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ANK1 RHOJ SLC26A9 HEPACAM2 QRICH2 ALAS2	1.74e-05	155	155	6	a16e3a72badafa78a3efc4f4ab62396f0ce99d1e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 FAT1 LIPG ATRNL1 LPL ERC2	1.80e-05	156	155	6	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ITGA4 LIPG ATRNL1 LPL ERC2	1.87e-05	157	155	6	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	COVID-19_Severe-NK_CD56bright\|World / disease group, cell group and cell class	ATP8B4 NWD1 AHRR CELSR3 KLHL23 NKG7	1.87e-05	157	155	6	9dcbabb377da7e93ec9f9abf09576a92877a7e02
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ANK1 RHOJ SLC26A9 HEPACAM2 QRICH2 ALAS2	2.47e-05	165	155	6	ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|metastatic_Brain / Location, Cell class and cell subclass	FLNA SYNPO2 NIPSNAP3B SPEG SNCAIP AOC3	2.56e-05	166	155	6	0da2c6ea1e62f1aafabafbbfbbcc6f7011739346
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNPO2 ARSJ RHOJ CEMIP2 LRP8 TENM1	2.73e-05	168	155	6	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 RHOJ SPEG AHRR SNCAIP PLXNA2	2.83e-05	169	155	6	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	COVID-19_Severe-CD4+_CTL\|World / disease group, cell group and cell class	NMNAT2 NECTIN3 CEMIP2 SYNE2 CATSPERB NKG7	2.83e-05	169	155	6	8c8168ac93a808d7b4756e4491db2b2979df1c1f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	ABCC4 ADGRV1 PTCHD1 FAT1 SYNE2 WDR86	2.92e-05	170	155	6	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNPO2 ARSJ RHOJ CEMIP2 LRP8 TENM1	2.92e-05	170	155	6	417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MXD3 ZNF573 ANK1 NFKBID FAM118B PHACTR1	3.02e-05	171	155	6	23b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNA CEMIP2 DUS2 CELSR3 SYNE2 CTSK	3.12e-05	172	155	6	eee45759284baa3ed77da6a5fbcc4f8f6c553106
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 SYNPO2 PPM1E FAT1 KLHL23 AOC3	3.33e-05	174	155	6	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA SYNPO2 TTC28 PTCHD1 AOC3 TENM1	3.66e-05	177	155	6	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA SYNPO2 SPEG PTCHD1 AOC3 PCDH10	3.66e-05	177	155	6	88403b055eb9fdf96e4695fb6e0d78179e30a1e3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA SYNPO2 SPEG PTCHD1 AOC3 PCDH10	3.66e-05	177	155	6	8903aeaab61abd81a148ea623038c5114b8a183b
ToppCell	lung\|World / shred on tissue and cell subclass	A2M RPL30 HINT1 RACK1 SYNE2 ENPP5	3.78e-05	178	155	6	7b1e371272328d6b6c3994382d64281ffc737db2
ToppCell	Control-Myeloid-Dendritic_cells\|Control / group, cell type (main and fine annotations)	MGAM ATP8B4 NFKBID ITGA4 STAB1 KYNU	4.02e-05	180	155	6	25ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS19 SYNPO2 ARSJ CEMIP2 LRP8 TENM1	4.15e-05	181	155	6	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ABCC4 STARD8 CEMIP2 SNCAIP ATRNL1	4.15e-05	181	155	6	4df7972f88117108698efd06b124b232f8588981
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCC4 ABCA13 NECTIN3 LRP8 CATSPERB PLXNA2	4.15e-05	181	155	6	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ABCC4 STARD8 CEMIP2 SNCAIP ATRNL1	4.15e-05	181	155	6	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 LIPG ATRNL1 LPL ERC2 WDR86	4.41e-05	183	155	6	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M LRP12 CEMIP2 LRP8 SYNE2 NKG7	4.41e-05	183	155	6	90c66ffd2c1f87c91f9a9886e28aeec542f9df85
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 FAT1 LIPG KLHL23 AOC3 KLHDC8B	4.55e-05	184	155	6	7128a2be291544d3df3ed6c80f21ddda8437dcba
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 FAT1 LIPG ATRNL1 LPL WDR86	4.55e-05	184	155	6	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 FAT1 LIPG KLHL23 AOC3 KLHDC8B	4.55e-05	184	155	6	55dde9c4eebac2a33788c1ff1d8fe312d150fad4
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-ACTC+_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ADAMTS19 FLNA SYNPO2 PPM1E PTCHD1 TENM1	4.55e-05	184	155	6	39168ca2bbf1369c9fe87c67f0aaff5e3cd03151
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	LRP12 ATP8B4 TTC28 ITGA4 ZNF106 PIK3CG	4.55e-05	184	155	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 FAT1 LIPG KLHL23 AOC3 KLHDC8B	4.55e-05	184	155	6	d14238f7b0b55a4c8d7040bea854bd221a66ac30
ToppCell	COVID-CD4-naive_CD4\|COVID / Condition, Cell_class and T cell subcluster	RPL30 HINT1 ITGA4 PASK SYNE2 TENM1	4.55e-05	184	155	6	00db55970d336a301035efe43a4ab4db62627f38
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 SYNPO2 PPM1E FAT1 KLHL23 AOC3	4.69e-05	185	155	6	a6cd90f8f30c7bdf66958cf403e73c193aa32f5e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NMNAT2 SYNPO2 PRSS12 SNCAIP ATRNL1 ERC2	4.69e-05	185	155	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS19 ABCA13 HEPACAM2 PTCHD1 LIPG PIK3CG	4.69e-05	185	155	6	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-pericyte_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 SYNPO2 PPM1E FAT1 KLHL23 AOC3	4.69e-05	185	155	6	5053f932e2adfcf4d6faaecff2999ac53d8d7aa5
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NPC1 A2M ABCC4 ATP8B4 FRYL ITGA4	4.83e-05	186	155	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCC4 ABCA13 SLC26A9 NECTIN3 LRP8 CATSPERB	4.83e-05	186	155	6	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 ARHGEF19 SYNPO2 SPEG FAT1 AOC3	4.97e-05	187	155	6	218c9b4f28499389c43005d9626af2ac01066027
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 ARHGEF19 SYNPO2 SPEG FAT1 AOC3	4.97e-05	187	155	6	c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NMNAT2 SYNPO2 NWD1 RHOJ SNCAIP AOC3	4.97e-05	187	155	6	ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ARHGEF19 SYNPO2 SPEG FAT1 AOC3	5.12e-05	188	155	6	61f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNA SYNPO2 SPEG ATRNL1 KLHL23 AOC3	5.12e-05	188	155	6	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FLNA SYNPO2 RHOJ SPEG ATRNL1 PLXNA2	5.12e-05	188	155	6	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NWD1 RHOJ CEMIP2 STAB1 SNCAIP	5.12e-05	188	155	6	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	droplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ARHGEF19 SYNPO2 SPEG FAT1 AOC3	5.12e-05	188	155	6	7553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell	Entopeduncular-Endothelial\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	HSPG2 FLNA RHOJ ITGA4 PARP14 SYNE2	5.12e-05	188	155	6	94774652fd42bad5012356672ffac8b6d2c22d37
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NWD1 RHOJ CEMIP2 STAB1 SNCAIP	5.43e-05	190	155	6	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NWD1 RHOJ CEMIP2 STAB1 SNCAIP	5.43e-05	190	155	6	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	A2M HSPG2 ANK1 TTC28 CUBN LIPG	5.59e-05	191	155	6	27a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	A2M HSPG2 ANK1 TTC28 CUBN LIPG	5.59e-05	191	155	6	1dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	NPC1 FLNA LRP12 ACADL LPL CTSK	5.59e-05	191	155	6	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	Fibroblast-D_(Pericyte)\|World / shred on cell class and cell subclass (v4)	FLNA SYNPO2 ITGA4 LIPG KLHL23 AOC3	5.76e-05	192	155	6	8c13c351fcc3d88e8c2ffa017e71ff6272cc6fac
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-IPC_like-IPCs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	RPL30 LRP8 IGSF10 RACK1 CBFA2T2 SYNE2	5.76e-05	192	155	6	bd91bf0ceeac49dc5a18aa2e401244db0ca596ae
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-IPC_like\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	RPL30 LRP8 IGSF10 RACK1 CBFA2T2 SYNE2	5.76e-05	192	155	6	18fbf485ad762ba7a9ac3e19bad136b0cf3af3c5
ToppCell	P28-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLNA SYNPO2 SPEG ITGA4 LIPG AOC3	5.76e-05	192	155	6	87c7780cf72f4c204f2a5f6655309d47a23c08ae
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA SYNPO2 PPM1E LIPG KLHL23 AOC3	5.93e-05	193	155	6	d0dcc0c11ccf99ff6b07e456d25b9742649aadd8
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SYNPO2 SPEG KLHL23 AOC3 KLHDC8B	5.93e-05	193	155	6	b9e11cd0896c0868aab7faec4ab7ab4d4e4d1b47
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA SYNPO2 ITGA4 LIPG KLHL23 AOC3	5.93e-05	193	155	6	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	HSPG2 RHOJ PARP14 CEMIP2 SYNE2 PLXNA2	5.93e-05	193	155	6	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-22\|World / Primary Cells by Cluster	RPL30 TTC28 PRSS12 RACK1 PLXNA2 RBFOX2	5.93e-05	193	155	6	3b927d4b8ecb21a408424ef91a23746c21741f49
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	A2M HSPG2 ARSJ RHOJ PRSS12 ITGA4	5.93e-05	193	155	6	e1de67ddada87229f5db0ec193a6da8745a86a64
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal-choroid_plexus/mesenchymal-like_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	A2M HSPG2 ARSJ RHOJ PRSS12 ITGA4	5.93e-05	193	155	6	b6f5a85210e60798205eaf5884cdb540f549d08a
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	A2M FLNA RHOJ LPL AOC3 PLXNA2	5.93e-05	193	155	6	5896242f713ae5fd1a4ebb63827f15d7279dced2
Drug	hydroxyl radicals	MGAM NMNAT2 GALC ATP8B4 IMPDH1 IMPDH2 PNLIPRP2 ACADL COPA RHOJ ESD PPM1E LIPF SLC26A9 SI GCDH HMGCR PFKL COQ2 ADA CS ANAPC1 LIPG LPL DHODH AOC3 KYNU	1.85e-07	1341	150	27	CID000000961
Drug	propanidid	PNLIPRP2 ESD LIPF BPHL LIPG LPL	1.32e-06	53	150	6	CID000015004
Drug	trimethylamine-cyanoborane	IMPDH1 IMPDH2 HMGCR	1.53e-05	8	150	3	CID006328234
Drug	1,4-Aptd	IMPDH1 IMPDH2 HMGCR	1.53e-05	8	150	3	CID000152126
Drug	phthaloylhydrazine	IMPDH1 IMPDH2 CTSK	3.25e-05	10	150	3	CID000219401
Drug	dicyclohexyl phthalate	A2M MGAM MYH4 CHAF1B ABCC4 HINT1 PNLIPRP2 ALS2 HMGCR CUBN TST STAB1 AHRR LPL AOC3 CTSK CNOT1	3.82e-05	836	150	17	ctd:C036042
Drug	gadolinium oxide	ESD SLC25A16	4.31e-05	2	150	2	CID000159427
Drug	hydroxymethylphosphonate	IMPDH1 IMPDH2	4.31e-05	2	150	2	CID000075795
Drug	6-Chloropurine Riboside, 5'-Monophosphate	IMPDH1 IMPDH2	4.31e-05	2	150	2	DB03948
Drug	Mycophenolate mofetil	IMPDH1 IMPDH2	4.31e-05	2	150	2	DB00688
Drug	purinogen	IMPDH1 IMPDH2	4.31e-05	2	150	2	CID003081226
Drug	AC1L9X6T	IMPDH1 IMPDH2	4.31e-05	2	150	2	CID000477594
Drug	Mycophenolic acid	IMPDH1 IMPDH2	4.31e-05	2	150	2	DB01024
Drug	aminoacetonitrile-HCl	MGAM CTSK	4.31e-05	2	150	2	CID000022340
Drug	AC1L5176	PNLIPRP2 LIPF LIPG	4.45e-05	11	150	3	CID000168098
Drug	Tranexamic acid [1197-18-8]; Down 200; 25.4uM; PC3; HT_HG-U133A	COPA NECTIN3 ZDHHC17 VPS13D LIPG CBFA2T2 UGT8 CTNS	4.51e-05	194	150	8	5762_DN
Drug	Zoxazolamine [61-80-3]; Down 200; 23.8uM; HL60; HT_HG-U133A	LRP12 COPA GCDH ITGA4 ZDHHC17 VPS13D DHODH RBFOX2	4.67e-05	195	150	8	1270_DN
Drug	Dyclonine hydrochloride [536-43-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	MXD3 ABCC4 NECTIN3 LRP8 TBX19 PASK VPS13D CTNS	4.85e-05	196	150	8	7423_UP
Drug	Terconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A	MXD3 ZNF573 ERAP1 RECQL GCDH FRYL CEMIP2 RBFOX2	4.85e-05	196	150	8	2844_DN
Drug	selenazofurin	NMNAT2 IMPDH1 IMPDH2 RBFOX2	4.96e-05	31	150	4	CID000100665
Drug	Furosemide [54-31-9]; Up 200; 12uM; MCF7; HT_HG-U133A	HSPG2 SPEG NECTIN3 ZZEF1 VPS13D LPL TENM1 CTSK	5.39e-05	199	150	8	6841_UP
Drug	Conessine [546-06-5]; Down 200; 11.2uM; HL60; HT_HG-U133A	MXD3 HSPG2 STARD8 COPA PASK CELSR3 TRAPPC9 RBFOX2	5.39e-05	199	150	8	2135_DN
Drug	AC1LCV0V	IMPDH1 IMPDH2 ADA RBFOX2	5.64e-05	32	150	4	CID000656468
Drug	thiazole-4-carboxamide	NMNAT2 IMPDH1 IMPDH2	5.90e-05	12	150	3	CID000445276
Drug	F-ddA	IMPDH1 IMPDH2 ADA	5.90e-05	12	150	3	CID000072180
Drug	tributyrin	PNLIPRP2 ESD LIPF LIPG LPL	6.47e-05	64	150	5	CID000006050
Drug	capecitabine	PNLIPRP2 ESD LIPF BPHL LIPG LPL	6.60e-05	104	150	6	CID000060953
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	1.33e-19	46	156	13	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15	4.54e-17	69	156	13	DOID:1682 (implicated_via_orthology)
Disease	glycerophospholipid measurement	MXD3 ARSJ SYNE2 UGT8	1.32e-04	49	156	4	EFO_0007630
Disease	trypanosomiasis (biomarker_via_orthology)	A2M ADA	1.65e-04	4	156	2	DOID:10113 (biomarker_via_orthology)
Disease	coronary artery disease (is_implicated_in)	HMGCR CUBN LRP8 LIPG LPL	1.95e-04	100	156	5	DOID:3393 (is_implicated_in)
Disease	progression free survival, ovarian serous carcinoma	MGAM ABCA13 ERC2	2.07e-04	22	156	3	EFO_0004920, EFO_1001516
Disease	Mycoplasma pneumoniae pneumonia (is_marker_for)	GALC ADA	2.75e-04	5	156	2	DOID:13276 (is_marker_for)
Disease	chronotype measurement, sun exposure measurement	ARSJ UGT8	2.75e-04	5	156	2	EFO_0008328, EFO_0010729
Disease	cholesterol to total lipids in small LDL percentage	HMGCR LIPG LPL	3.86e-04	27	156	3	EFO_0022241
Disease	cholesterol to total lipids in medium LDL percentage	HMGCR LIPG LPL	3.86e-04	27	156	3	EFO_0022238
Disease	retinitis pigmentosa	ITGA4 TMEM271	4.11e-04	6	156	2	MONDO_0019200
Disease	muscular disease (is_implicated_in)	HMGCR LPL	4.11e-04	6	156	2	DOID:0080000 (is_implicated_in)
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 LIPG LPL DHODH	4.45e-04	67	156	4	EFO_0008595, EFO_0020946
Disease	peritonitis (biomarker_via_orthology)	A2M ADA	5.73e-04	7	156	2	DOID:8283 (biomarker_via_orthology)
Disease	endoplasmic reticulum aminopeptidase 1 measurement	ERAP1 ERC2	5.73e-04	7	156	2	EFO_0008119
Disease	Headache, HOMA-B	ZNF106 SNCAIP	5.73e-04	7	156	2	EFO_0004469, HP_0002315
Disease	nucleotide measurement	ATP8B4 HMGCR SYNE2 PLXNA2	6.16e-04	73	156	4	EFO_0010513
Disease	Mental Retardation, X-Linked 1	MID2 PTCHD1 USP27X	6.42e-04	32	156	3	C2931498
Disease	Hereditary spherocytosis	ANK1 DHODH	7.62e-04	8	156	2	C0037889
Disease	response to selective serotonin reuptake inhibitor	SLC26A9 PTCHD1 KYNU PHACTR1	9.54e-04	82	156	4	EFO_0005658
Disease	glioblastoma (implicated_via_orthology)	USP22 USP27X	9.76e-04	9	156	2	DOID:3068 (implicated_via_orthology)
Disease	uveitis	ERAP1 ERC2	9.76e-04	9	156	2	EFO_1001231
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	HMGCR ZNF106 LIPG LPL SYNE2	1.03e-03	144	156	5	EFO_0004611, EFO_0020943
Disease	Congenital disorder of glycosylation	MPDU1 MAGT1 COG6	1.07e-03	38	156	3	cv:C0282577
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	HMGCR ZNF106 LIPG ZNF335 LPL SYNE2	1.21e-03	222	156	6	EFO_0008317, EFO_0020943
Disease	cervix carcinoma (is_implicated_in)	ERAP1 BAK1	1.22e-03	10	156	2	DOID:2893 (is_implicated_in)
Disease	fibrinogen measurement, coronary artery disease	HINT1 FCHO1 LPL DHODH PHACTR1	1.39e-03	154	156	5	EFO_0001645, EFO_0004623
Disease	primary immunodeficiency disease (is_implicated_in)	FCHO1 DPP9 PIK3CG	1.43e-03	42	156	3	DOID:612 (is_implicated_in)
Disease	hip geometry	ADGRV1 ERC2 PHACTR1	1.64e-03	44	156	3	EFO_0004685
Disease	total lipids in very small VLDL measurement	HMGCR LIPG LPL	1.75e-03	45	156	3	EFO_0022156
Disease	dementia (is_implicated_in)	HMGCR LRP8	1.77e-03	12	156	2	DOID:1307 (is_implicated_in)
Disease	intracranial aneurysm (biomarker_via_orthology)	AOC3 CTSK	2.08e-03	13	156	2	DOID:10941 (biomarker_via_orthology)
Disease	Hyperlipoproteinemia Type IIb	HMGCR LPL	2.08e-03	13	156	2	C1704417
Disease	myopathy (implicated_via_orthology)	FLNA MYH4 HMGCR	2.11e-03	48	156	3	DOID:423 (implicated_via_orthology)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 LIPG LPL SYNE2	2.21e-03	103	156	4	EFO_0008595, EFO_0020944
Disease	apolipoprotein B to apolipoprotein A1 ratio	HMGCR LIPG LPL	2.23e-03	49	156	3	EFO_0021897
Disease	Autistic Disorder	ITGA4 ADA PASK PTCHD1 PIK3CG PCDH10	2.72e-03	261	156	6	C0004352
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	HMGCR ZNF106 LIPG ZNF335 LPL SYNE2	2.88e-03	264	156	6	EFO_0008317, EFO_0020944
Disease	metabolite measurement	ABCC4 ATP8B4 HINT1 PNLIPRP2 ACADL LIPF STAB1 LPL SYNE2	3.05e-03	560	156	9	EFO_0004725
Disease	Hyperlipoproteinemia Type IIa	HMGCR LPL	3.17e-03	16	156	2	C0745103
Disease	Spondyloepiphyseal Dysplasia	HSPG2 FLNA	3.17e-03	16	156	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	HSPG2 FLNA	3.17e-03	16	156	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	HSPG2 FLNA	3.17e-03	16	156	2	C4551479
Disease	Schwartz-Jampel Syndrome	HSPG2 FLNA	3.17e-03	16	156	2	C0036391
Disease	Melnick-Needles Syndrome	HSPG2 FLNA	3.17e-03	16	156	2	C0025237
Disease	Van Buchem disease	HSPG2 FLNA	3.59e-03	17	156	2	C0432272
Disease	cholesterol in IDL measurement	HMGCR LIPG LPL	3.61e-03	58	156	3	EFO_0021899
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 LIPG LPL SYNE2	3.96e-03	121	156	4	EFO_0008595, EFO_0020943
Disease	total lipids in IDL	HMGCR LIPG LPL	3.98e-03	60	156	3	EFO_0022161
Disease	Hypercholesterolemia, Familial	HMGCR LPL	4.02e-03	18	156	2	C0020445
Disease	osteochondrodysplasia (is_implicated_in)	HSPG2 FLNA	4.48e-03	19	156	2	DOID:2256 (is_implicated_in)
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	LIPG LPL	4.48e-03	19	156	2	EFO_0004612, EFO_0008589
Disease	Osteochondrodysplasias	HSPG2 FLNA	4.48e-03	19	156	2	C0029422
Disease	Dyschondroplasias	HSPG2 FLNA	4.48e-03	19	156	2	C0013366
Disease	triglycerides to total lipids in medium VLDL percentage	HMGCR ZNF335 LPL	4.56e-03	63	156	3	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	HMGCR ZNF335 LPL	4.56e-03	63	156	3	EFO_0022239
Disease	anti-Mullerian hormone measurement	MYH4 TTC28	4.96e-03	20	156	2	EFO_0004769
Disease	urinary microalbumin measurement	CUBN SLC25A16	4.96e-03	20	156	2	EFO_0010967
Disease	Multiple Epiphyseal Dysplasia	HSPG2 FLNA	4.96e-03	20	156	2	C0026760

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSRQQVYISHLGHGV	AHRR	581	A9YTQ3
YISIHNLEASLGVHT	CTSK	56	P43235
GYHQSASEHGLVVIA	ESD	66	P10768
GHVQAYQEAVKSGIH	ADA	196	P00813
TLHHGLNIYATEGTL	CATSPERB	136	Q9H7T0
IHSGIVMSYITNHGS	ACADL	136	P28330
HVYQHGLTGFLGQVT	BAK1	141	Q16611
VIHLEAGGYHSLALT	ALS2	561	Q96Q42
HENVVAHLINYGTKG	ANK1	156	P16157
GYSTVTLNVIRHHGT	ADGRV1	1881	Q8WXG9
VYSLDFQHGTAGRIH	CHAF1B	16	Q13112
LHQLHLTGYGISDTT	ABCA13	4136	Q86UQ4
TGDYALIINGHSLAH	ATP8B4	751	Q8TF62
QNVTHNDAGIYTLHV	CEACAM7	111	Q14002
GHTQTVQAHYILNGG	A2M	471	P01023
KYGNQVSEHTLGTVH	AOC3	506	Q16853
QVKGEHSYTGIIHAF	SLC25A16	161	P16260
EQTHGQLLVAHVLGY	NWD1	571	Q149M9
HVLGYIVSSRHGLSE	NWD1	581	Q149M9
VGVFHTEYGALNRVH	NIPSNAP3A	181	Q9UFN0
AYGVAQSVVNLSVHG	HSPG2	3096	P98160
TNHIGHTGYLNTVTV	RACK1	186	P63244
QHGLVSVSAYQHGMT	QRICH2	296	Q9H0J4
HTQDYAGQTGEHNLT	RBFOX2	56	O43251
EHNLTLYGSTQAHGE	RBFOX2	66	O43251
EHSGAFNLAGTTVHY	ADAMTS19	846	Q8TE59
YIHSLSVAVGHFLGS	ARHGEF19	391	Q8IW93
GIGLVYQGTAHRHTA	ANAPC1	1256	Q9H1A4
GSYAHSVEDTHVQIG	FCHO1	216	O14526
SNSHIHYSIIDGNQG	FAT1	3366	Q14517
GSLVAHIKVGETYHQ	PAN2	866	Q504Q3
ALGAVGAHLTHQIYT	COQ2	306	Q96H96
SSVHEGRVELYHAGQ	PRSS12	286	P56730
HGYVSGEDVAGQHIT	PASK	261	Q96RG2
YGNGALAEHSENVHI	LRP12	26	Q9Y561
LLRGFVAGQEHSYSH	MXD3	186	Q9BW11
YIHGSSQAQFVAETH	MAGT1	256	Q9H0U3
HQGRSVLHVAATYGL	NFKBID	116	Q8NI38
IGGYNAHAANIVTAI	HMGCR	746	P04035
TGKYQIHTGLQHSII	ARSJ	131	Q5FYB0
SAQVEGGVHSLHSYE	IMPDH2	496	P12268
HSYHVEGNLVNTNAG	MGAM	136	O43451
LSFYQHIITVGTGHG	DCAF12L2	356	Q5VW00
NLFLSAGTDGHVHLY	DYNC2I2	406	Q96EX3
EGHQFLVGTEESHIY	CFAP52	301	Q8N1V2
TVVIHYAGNLSETFH	ERAP1	146	Q9NZ08
TGQKQLHYVGHSQGT	LIPF	161	P07098
LHYVGHSQGTTIGFI	LIPF	166	P07098
HHSLGLNGGYQDELV	CBFA2T2	321	O43439
NHLTVHQGTGAVYVG	PLXNA2	51	O75051
DNVHLLGYSLGAHAA	LPL	151	P06858
AVRTGISHGHTVYVV	PFKL	421	P17858
HYTLVTGLFAENHGI	ENPP5	76	Q9UJA9
HKEGYSGTNTGNVHI	FRYL	161	O94915
AYVHTTGQVVSFGHG	HERC6	301	Q8IVU3
AHVNLGYTKVVGVFH	NIPSNAP3B	171	Q9BS92
GNVHLIGYSLGAHVA	LIPG	161	Q9Y5X9
HTDVLSYTDQHGGLT	ERC2	111	O15083
GSDGGQSVYHVHLHV	HINT1	101	P49773
HYTVQEEQEHGTFVG	PCDH10	21	Q9P2E7
DHYAVTVTVGGKQHL	RHOJ	56	Q9H4E5
VSHQYGALTFVDEVH	ALAS2	346	P22557
SAQIEGGVHGLHSYE	IMPDH1	496	P20839
QLQYGSHGQHLPSTT	PHACTR1	286	Q9C0D0
GGVDAAIYASIHLHV	PPM1E	276	Q8WY54
HAAYSSAVNILLGHG	NPC1	1016	O15118
HGLVSVHGRIAYVSQ	ABCC4	466	O15439
VRVLTGIYTHGNHSL	PARP14	1741	Q460N5
LKFYHHTISGIVGNS	COG6	381	Q9Y2V7
HLQGLSGHYLTISFE	CUBN	2366	O60494
YQENGIHHTVFIGET	IGSF10	576	Q6WRI0
SGIHHDILEGLVNYA	KLHL23	81	Q8NBE8
NTYEGTHDIHALILG	GCDH	411	Q92947
NNQHGYEAGSVALHV	DPP9	776	Q86TI2
EVYIQDHGDGTHTIT	FLNA	1206	P21333
SNHIKYAVTTGDHGI	COPA	546	P53621
RLYLTIHSDHEGGNV	CS	256	O75390
SHQTGIPARGSHYIA	CNTF	181	P26441
LSHGGLNSIFETIYH	UGT8	356	Q16880
TVLGHGQQYAVEGHS	ATRNL1	401	Q5VV63
THYILIQDGGALHIG	CEMIP2	176	Q9UHN6
LFGYSVVLHSHGANR	ITGA4	51	P13612
SVLHIHGVYTNPSGI	FAM118B	201	Q9BPY3
RVYGTVAHQDGHLLV	KLHDC8B	21	Q8IXV7
NHAAVAVGHRVYSFG	KLHDC3	16	Q9BQ90
HGLQHYFSSRGIAIA	KHNYN	451	O15037
VPSHTVHGVRGQALY	HEPACAM2	36	A8MVW5
GDDIIYHTASVGILH	EML5	1386	Q05BV3
YHTASVGILHNVATG	EML5	1391	Q05BV3
SQNVGQLTVYLHGNH	CTNS	91	O60931
QLTVYLHGNHSNQTG	CTNS	96	O60931
VIANGGSHDHIQQYS	DUS2	211	Q9NX74
HYNIISGNSRGHFAI	CELSR3	581	Q9NYQ7
LHYQQTGEGDHAVLL	BPHL	51	Q86WA6
VVDVIGAHYPGTHSA	GALC	246	P54803
HTQLHAYIGVSLVLG	SLC39A9	101	Q9NUM3
GHGDIISGYIHVTQT	NKG7	46	Q16617
TQLGYSLEDVHVIGH	PNLIPRP2	156	P54317
DELHIGRTAQIGHVY	LRP8	876	Q14114
TASYVAGILHATIHI	OR5T3	176	Q8NGG3
VHQHYQGAGTAVNGT	SOX3	426	P41225
YVHTVSLDKGENHGI	SERAC1	76	Q96JX3
TGALVLHNIGYSAQH	SYNE2	2486	Q8WXH0
NIHAQVYNDISHGGV	SLC26A9	701	Q7LBE3
VVVSHEGYLSHTGLA	TCAF2	61	A6NFQ2
HLQVEGHSNVYAIGD	AIFM2	271	Q9BRQ8
VYNGHQLGGVTVHSK	PTCHD1	186	Q96NR3
ALHVITGLLEHYGQG	SCRN2	131	Q96FV2
YGFNSHGLSVVEHRL	DHODH	146	Q02127
HRGLLYAASHSGVVQ	SEMA4B	506	Q9NPR2
DGNSAVHVASQHGYL	SNCAIP	456	Q9Y6H5
VHVASQHGYLGCIQT	SNCAIP	461	Q9Y6H5
LVGVNVSFLHHSDYG	TENM1	901	Q9UKZ4
GSIEIDHTQYKFGHT	MYH4	751	Q9Y623
ASYDTINLHVRGGHI	SI	1676	P14410
AYGIAVNATIHIVAH	NOX3	106	Q9HBY0
ASYVAGILHATIHTV	OR5T2	186	Q8NGG2
NYHNGHTGQLSAITV	MPDU1	176	O75352
SGGSYAHLDDILQHV	STARD8	301	Q92502
GGRGAIQFVTHYQHS	SEC23B	476	Q15437
YVGTQAIAHIHNKGS	CNOT1	2221	A5YKK6
GVTGYHEQLTIHGKD	PIK3CG	331	P48736
TVSLQNLGIHAGAYH	RECQL	331	P46063
TVYGQLTRHQSIHTG	ZNF30	326	P17039
TGSYLVQHQRIHTGE	ZNF30	411	P17039
VYGQLIGHQSVHTGE	ZNF30	551	P17039
LFAVVNHQGTLESGH	USP27X	366	A6NNY8
NHQGTLESGHYTSFI	USP27X	371	A6NNY8
FAVVNHQGTLESGHY	USP22	466	Q9UPT9
SGYQLTVHQRFHTGE	ZNF573	201	Q86YE8
AFGTSSQLGHLEHVY	ZNF19	421	P17023
HLTHGGYVESTTLQI	SYNPO2	106	Q9UMS6
QTYVHFQDNHGVTVG	TIAM2	811	Q8IVF5
EGLYAVSAVNTHGQA	SPEG	1131	Q15772
LAKTGVHHYSGNNIE	RPL30	66	P62888
THILNAAHGTGVYTG	STYXL2	161	Q5VZP5
HSKDTTLIHQIFGGY	USP17L18	186	D6R9N7
HSKDTTLIHQIFGGY	USP17L5	186	A8MUK1
HSKDTTLIHQIFGGY	USP17L21	186	D6R901
QVHAVSFYSKGHGVA	nan	151	A8MX80
YGHLLHEVQKATQTG	STAB1	356	Q9NY15
HSKDTTLIHQIFGGY	USP17L19	186	D6RCP7
VIQNDQGHTSVLHSY	RALGAPB	11	Q86X10
IHLAAQFGHTSIVAY	ZDHHC17	161	Q8IUH5
SLQAHQGVHTGEKSY	ZNF226	461	Q9NYT6
QVHAVSFYSKGHGVA	nan	121	A8MV72
HSKDTTLIHQIFGGY	USP17L12	186	C9JPN9
THGNLAVAYQALGAH	TTC28	556	Q96AY4
QVHAVSFYSKGHGVA	nan	151	Q8N9G6
QVHAVSFYSKGHGVA	nan	151	A8MUA0
HSKDTTLIHQIFGGY	USP17L24	186	Q0WX57
VVISNAGHLNETYHL	ZZEF1	2121	O43149
GVHNYDLHDTVSFVG	TRAPPC9	1071	Q96Q05
SGANLAYHQRIHTGE	ZNF345	101	Q14585
HSKDTTLIHQIFGGY	USP17L6P	186	Q6QN14
FAEYVGRLGISNHTH	TST	81	Q16762
GRLGISNHTHVVVYD	TST	86	Q16762
SNHTHVVVYDGEHLG	TST	91	Q16762
NHYTVHGLQSGTRYI	MID2	496	Q9UJV3
AISESQHVTYSHLGG	TBX19	231	O60806
HSKDTTLIHQIFGGY	USP17L22	186	D6RA61
AGTHYIMATDGTQLH	ZNF335	921	Q9H4Z2
HSKDTTLIHQIFGGY	USP17L15	186	C9J2P7
HSKDTTLIHQIFGGY	USP17L17	186	D6RBQ6
GFAAHHAVSYINVGV	TMEM271	316	A0A286YF58
IQVHGQVLYTASHDG	WDR86	321	Q86TI4
GSQLTYHQRIHSGEK	ZNF571	291	Q7Z3V5
YKGHNHAVTVVNILG	ZNF106	1736	Q9H2Y7
HSKDTTLIHQIFGGY	USP17L20	186	D6RJB6
HSKDTTLIHQIFGGY	USP17L10	186	C9JJH3
NGQVHLYEATTGNLH	WDR54	231	Q9H977
HSKDTTLIHQIFGGY	USP17L11	186	C9JVI0
HGQHDLGQSIFYTTT	UNC79	146	Q9P2D8
RYHAATSGEHLVAGI	VPS13D	4136	Q5THJ4
AVILFSGVHFYTGQH	KYNU	216	Q16719
ALQHGDGHVVDYLSQ	NMNAT2	276	Q9BZQ4
TVAVHHPQYGFSVQG	NECTIN3	101	Q9NQS3