Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1D CACNB2	4.51e-05	5	43	2	GO:0086007
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1D CACNB2	1.62e-04	9	43	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1D CACNB2	1.62e-04	9	43	2	GO:0099626
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1C NCF1B	2.02e-04	10	43	2	GO:0016176
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1C NCF1B	2.95e-04	12	43	2	GO:0016175
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1D CACNB2	4.05e-04	14	43	2	GO:0008331
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	NCF1C NCF1B	8.40e-04	20	43	2	GO:0050664
GeneOntologyBiologicalProcess	negative regulation of smooth muscle contraction	GUCY1A1 NCF1C NCF1B	1.18e-05	22	42	3	GO:0045986
GeneOntologyBiologicalProcess	regulation of transporter activity	CACNA1D CACNB2 KLHL24 SGK1 WNK2 ABCB1	2.98e-05	299	42	6	GO:0032409
GeneOntologyBiologicalProcess	neutrophil-mediated killing of gram-positive bacterium	NCF1C NCF1B	4.03e-05	5	42	2	GO:0070946
GeneOntologyBiologicalProcess	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1D CACNB2	4.03e-05	5	42	2	GO:1904879
GeneOntologyBiologicalProcess	negative regulation of muscle contraction	GUCY1A1 NCF1C NCF1B	4.91e-05	35	42	3	GO:0045932
GeneOntologyBiologicalProcess	positive regulation of transporter activity	CACNB2 SGK1 WNK2 ABCB1	6.58e-05	107	42	4	GO:0032411
GeneOntologyBiologicalProcess	positive regulation of neuron maturation	GRIP2 OPA1	8.45e-05	7	42	2	GO:0014042
GeneOntologyBiologicalProcess	neutrophil-mediated killing of fungus	NCF1C NCF1B	8.45e-05	7	42	2	GO:0070947
GeneOntologyBiologicalProcess	NADP catabolic process	NCF1C NCF1B	8.45e-05	7	42	2	GO:0006742
GeneOntologyBiologicalProcess	muscle contraction	CACNA1D CACNB2 GRIP2 GUCY1A1 NCF1C NCF1B	1.49e-04	400	42	6	GO:0006936
GeneOntologyBiologicalProcess	smooth muscle contraction	GRIP2 GUCY1A1 NCF1C NCF1B	1.53e-04	133	42	4	GO:0006939
GeneOntologyBiologicalProcess	regulation of monoatomic ion transmembrane transporter activity	CACNA1D CACNB2 KLHL24 WNK2 ABCB1	1.66e-04	256	42	5	GO:0032412
GeneOntologyBiologicalProcess	regulation of transmembrane transporter activity	CACNA1D CACNB2 KLHL24 WNK2 ABCB1	1.98e-04	266	42	5	GO:0022898
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	CACNA1D CACNB2 SGK1 WNK2 ABCB1	1.98e-04	266	42	5	GO:0043270
GeneOntologyBiologicalProcess	regulation of respiratory burst involved in inflammatory response	NCF1C NCF1B	2.20e-04	11	42	2	GO:0060264
GeneOntologyBiologicalProcess	respiratory burst involved in inflammatory response	NCF1C NCF1B	3.11e-04	13	42	2	GO:0002536
GeneOntologyBiologicalProcess	positive regulation of cell maturation	GRIP2 OPA1	3.63e-04	14	42	2	GO:1903431
GeneOntologyBiologicalProcess	medium-chain fatty acid metabolic process	OLAH CRAT	4.18e-04	15	42	2	GO:0051791
GeneOntologyBiologicalProcess	neutrophil-mediated killing of bacterium	NCF1C NCF1B	4.77e-04	16	42	2	GO:0070944
GeneOntologyBiologicalProcess	regulation of smooth muscle contraction	GUCY1A1 NCF1C NCF1B	5.57e-04	79	42	3	GO:0006940
GeneOntologyBiologicalProcess	regulation of neuron maturation	GRIP2 OPA1	6.07e-04	18	42	2	GO:0014041
GeneOntologyBiologicalProcess	response to yeast	NCF1C NCF1B	6.07e-04	18	42	2	GO:0001878
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transmembrane transport	CACNA1D CACNB2 WNK2 ABCB1	6.18e-04	192	42	4	GO:0034767
GeneOntologyBiologicalProcess	regulation of system process	CACNA1D CACNB2 GRIP2 GUCY1A1 NCF1C NCF1B SGK1	6.39e-04	734	42	7	GO:0044057
GeneOntologyBiologicalProcess	neutrophil-mediated killing of symbiont cell	NCF1C NCF1B	6.77e-04	19	42	2	GO:0070943
GeneOntologyBiologicalProcess	regulation of muscle contraction	CACNB2 GUCY1A1 NCF1C NCF1B	7.47e-04	202	42	4	GO:0006937
GeneOntologyBiologicalProcess	respiratory burst involved in defense response	NCF1C NCF1B	7.51e-04	20	42	2	GO:0002679
GeneOntologyBiologicalProcess	muscle system process	CACNA1D CACNB2 GRIP2 GUCY1A1 NCF1C NCF1B	7.89e-04	547	42	6	GO:0003012
GeneOntologyBiologicalProcess	neutrophil mediated cytotoxicity	NCF1C NCF1B	8.29e-04	21	42	2	GO:0070942
GeneOntologyBiologicalProcess	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1D CACNB2	9.11e-04	22	42	2	GO:1902514
GeneOntologyBiologicalProcess	hydrogen peroxide biosynthetic process	NCF1C NCF1B	9.11e-04	22	42	2	GO:0050665
GeneOntologyBiologicalProcess	membrane depolarization during cardiac muscle cell action potential	CACNA1D CACNB2	9.97e-04	23	42	2	GO:0086012
GeneOntologyBiologicalProcess	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1D CACNB2	9.97e-04	23	42	2	GO:0061577
GeneOntologyBiologicalProcess	regulation of respiratory burst	NCF1C NCF1B	9.97e-04	23	42	2	GO:0060263
GeneOntologyBiologicalProcess	positive regulation of ion transmembrane transporter activity	CACNB2 WNK2 ABCB1	1.01e-03	97	42	3	GO:0032414
GeneOntologyBiologicalProcess	regulation of potassium ion transmembrane transport	CACNA1D KLHL24 WNK2	1.01e-03	97	42	3	GO:1901379
GeneOntologyBiologicalProcess	regulation of monoatomic ion transport	CACNA1D CACNB2 KLHL24 SGK1 WNK2 ABCB1	1.04e-03	577	42	6	GO:0043269
GeneOntologyBiologicalProcess	regulation of sodium ion transport	KLHL24 SGK1 WNK2	1.14e-03	101	42	3	GO:0002028
GeneOntologyBiologicalProcess	regulation of monoatomic ion transmembrane transport	CACNA1D CACNB2 KLHL24 WNK2 ABCB1	1.52e-03	417	42	5	GO:0034765
GeneOntologyCellularComponent	ribbon synapse	CACNA1D CACNB2 OTOF	3.86e-05	32	43	3	GO:0097470
GeneOntologyCellularComponent	cochlear hair cell ribbon synapse	CACNA1D OTOF	6.17e-05	6	43	2	GO:0098683
GeneOntologyCellularComponent	L-type voltage-gated calcium channel complex	CACNA1D CACNB2	2.69e-04	12	43	2	GO:1990454
GeneOntologyCellularComponent	NADPH oxidase complex	NCF1C NCF1B	6.19e-04	18	43	2	GO:0043020
GeneOntologyCellularComponent	dendrite	MAPK8IP1 CACNA1D GRIP2 NCF1C NCF1B CDH9 OPA1	1.70e-03	858	43	7	GO:0030425
GeneOntologyCellularComponent	dendritic tree	MAPK8IP1 CACNA1D GRIP2 NCF1C NCF1B CDH9 OPA1	1.72e-03	860	43	7	GO:0097447
MousePheno	decreased susceptibility to Orthomyxoviridae infection	OLAH NCF1C NCF1B	9.55e-06	18	33	3	MP:0020947
MousePheno	increased angiotensin I-converting enzyme activity	NCF1C NCF1B	8.06e-05	6	33	2	MP:0003184
MousePheno	abnormal angiotensin I-converting enzyme activity	NCF1C NCF1B	8.06e-05	6	33	2	MP:0013254
MousePheno	liver abscess	NCF1C NCF1B	1.13e-04	7	33	2	MP:0003332
MousePheno	abnormal inner hair cell synaptic ribbon morphology	CACNA1D OTOF	1.13e-04	7	33	2	MP:0004562
MousePheno	impaired granulocyte bactericidal activity	NCF1C NCF1B	2.40e-04	10	33	2	MP:0005074
MousePheno	abnormal susceptibility to Orthomyxoviridae infection	OLAH NCF1C NCF1B	2.74e-04	54	33	3	MP:0020945
Domain	ARM-type_fold	IPO5 WDFY4 STAG2 PI4KA	6.36e-03	339	41	4	IPR016024
Domain	SH3	MAP3K9 MAPK8IP1 CACNB2	1.18e-02	216	41	3	PS50002
Domain	SH3	MAP3K9 MAPK8IP1 CACNB2	1.18e-02	216	41	3	SM00326
Domain	SH3_domain	MAP3K9 MAPK8IP1 CACNB2	1.24e-02	220	41	3	IPR001452
Domain	SH3_9	MAP3K9 MAPK8IP1	1.27e-02	78	41	2	PF14604
Pubmed	Functional pseudogenes inhibit the superoxide production.	NCF1C NCF1B	1.56e-06	2	44	2	26086043
Pubmed	Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness.	CACNA1D OTOF	1.56e-06	2	44	2	33036242
Pubmed	Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells.	CACNA1D OTOF	1.56e-06	2	44	2	28193694
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1C NCF1B	4.69e-06	3	44	2	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1C NCF1B	4.69e-06	3	44	2	10678931
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1C NCF1B	4.69e-06	3	44	2	27044504
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1C NCF1B	4.69e-06	3	44	2	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1C NCF1B	4.69e-06	3	44	2	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1C NCF1B	4.69e-06	3	44	2	10891396
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1C NCF1B	4.69e-06	3	44	2	25474113
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1C NCF1B	4.69e-06	3	44	2	18787174
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1C NCF1B	4.69e-06	3	44	2	26209274
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1C NCF1B	4.69e-06	3	44	2	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1C NCF1B	4.69e-06	3	44	2	22184329
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1C NCF1B	4.69e-06	3	44	2	11018074
Pubmed	[PPARγ signal transduction pathway in the foam cell formation induced by visfatin].	SOAT1 ABCB1	4.69e-06	3	44	2	20945045
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1C NCF1B	4.69e-06	3	44	2	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1C NCF1B	4.69e-06	3	44	2	20142487
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1C NCF1B	4.69e-06	3	44	2	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1C NCF1B	4.69e-06	3	44	2	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1C NCF1B	4.69e-06	3	44	2	21570954
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1C NCF1B	4.69e-06	3	44	2	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1C NCF1B	4.69e-06	3	44	2	39357591
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1C NCF1B	4.69e-06	3	44	2	12958309
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1C NCF1B	4.69e-06	3	44	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1C NCF1B	4.69e-06	3	44	2	31118934
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1C NCF1B	4.69e-06	3	44	2	23482812
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1C NCF1B	4.69e-06	3	44	2	16041040
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1C NCF1B	4.69e-06	3	44	2	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1C NCF1B	4.69e-06	3	44	2	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1C NCF1B	4.69e-06	3	44	2	21435178
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1C NCF1B	4.69e-06	3	44	2	18703411
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1C NCF1B	4.69e-06	3	44	2	29228045
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1C NCF1B	4.69e-06	3	44	2	17307863
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1C NCF1B	4.69e-06	3	44	2	22155727
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1C NCF1B	4.69e-06	3	44	2	27829407
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1C NCF1B	4.69e-06	3	44	2	24576409
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1C NCF1B	4.69e-06	3	44	2	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1C NCF1B	4.69e-06	3	44	2	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1C NCF1B	4.69e-06	3	44	2	28274989
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1C NCF1B	4.69e-06	3	44	2	26645958
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1C NCF1B	4.69e-06	3	44	2	12364355
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1C NCF1B	4.69e-06	3	44	2	24549323
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1C NCF1B	4.69e-06	3	44	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1C NCF1B	4.69e-06	3	44	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1C NCF1B	4.69e-06	3	44	2	10670582
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1C NCF1B	4.69e-06	3	44	2	20881184
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1C NCF1B	4.69e-06	3	44	2	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1C NCF1B	4.69e-06	3	44	2	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1C NCF1B	4.69e-06	3	44	2	20864666
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1C NCF1B	4.69e-06	3	44	2	23328631
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1C NCF1B	4.69e-06	3	44	2	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1C NCF1B	4.69e-06	3	44	2	17114280
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1C NCF1B	4.69e-06	3	44	2	19168575
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1C NCF1B	4.69e-06	3	44	2	25989352
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1C NCF1B	4.69e-06	3	44	2	19503084
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1C NCF1B	4.69e-06	3	44	2	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1C NCF1B	4.69e-06	3	44	2	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1C NCF1B	4.69e-06	3	44	2	36592568
Pubmed	Genetic requirement of p47phox for superoxide production by murine microglia.	NCF1C NCF1B	4.69e-06	3	44	2	11156938
Pubmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	NCF1C NCF1B	4.69e-06	3	44	2	30504842
Pubmed	Genomic structure of the human p47-phox (NCF1) gene.	NCF1C NCF1B	4.69e-06	3	44	2	10772875
Pubmed	A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification.	NCF1C NCF1B	4.69e-06	3	44	2	27798190
Pubmed	Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.	NCF1C NCF1B	4.69e-06	3	44	2	20702812
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1C NCF1B	4.69e-06	3	44	2	33705493
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1C NCF1B	4.69e-06	3	44	2	23965970
Pubmed	Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.	NCF1C NCF1B	4.69e-06	3	44	2	26455429
Pubmed	Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.	NCF1C NCF1B	4.69e-06	3	44	2	15513930
Pubmed	Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.	NCF1C NCF1B	4.69e-06	3	44	2	15626477
Pubmed	Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.	NCF1C NCF1B	4.69e-06	3	44	2	15033459
Pubmed	NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.	NCF1C NCF1B	4.69e-06	3	44	2	19077231
Pubmed	Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.	NCF1C NCF1B	4.69e-06	3	44	2	20828610
Pubmed	p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.	NCF1C NCF1B	4.69e-06	3	44	2	20817944
Pubmed	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.	NCF1C NCF1B	4.69e-06	3	44	2	22319452
Pubmed	Early determinants of H2O2-induced endothelial dysfunction.	NCF1C NCF1B	4.69e-06	3	44	2	16895801
Pubmed	Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.	NCF1C NCF1B	4.69e-06	3	44	2	20690191
Pubmed	Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.	NCF1C NCF1B	4.69e-06	3	44	2	16772302
Pubmed	Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.	NCF1C NCF1B	4.69e-06	3	44	2	32504071
Pubmed	Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.	NCF1C NCF1B	4.69e-06	3	44	2	16280459
Pubmed	Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.	NCF1C NCF1B	4.69e-06	3	44	2	18185592
Pubmed	NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.	NCF1C NCF1B	4.69e-06	3	44	2	36853827
Pubmed	Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.	NCF1C NCF1B	4.69e-06	3	44	2	23024271
Pubmed	Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.	NCF1C NCF1B	4.69e-06	3	44	2	21253614
Pubmed	Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.	NCF1C NCF1B	4.69e-06	3	44	2	25873172
Pubmed	Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.	NCF1C NCF1B	4.69e-06	3	44	2	15310853
Pubmed	Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.	NCF1C NCF1B	4.69e-06	3	44	2	31393787
Pubmed	Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.	NCF1C NCF1B	4.69e-06	3	44	2	10725280
Pubmed	Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.	CACNA1D OTOF	4.69e-06	3	44	2	28696301
Pubmed	Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.	NCF1C NCF1B	4.69e-06	3	44	2	34970267
Pubmed	Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.	NCF1C NCF1B	4.69e-06	3	44	2	25689796
Pubmed	Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.	NCF1C NCF1B	4.69e-06	3	44	2	14993144
Pubmed	Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.	NCF1C NCF1B	4.69e-06	3	44	2	22050439
Pubmed	The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.	NCF1C NCF1B	4.69e-06	3	44	2	12031896
Pubmed	NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.	NCF1C NCF1B	4.69e-06	3	44	2	11249873
Pubmed	Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.	NCF1C NCF1B	4.69e-06	3	44	2	15936744
Pubmed	NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.	NCF1C NCF1B	4.69e-06	3	44	2	17220182
Pubmed	NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse.	NCF1C NCF1B	4.69e-06	3	44	2	25628043
Pubmed	The p47phox mouse knock-out model of chronic granulomatous disease.	NCF1C NCF1B	4.69e-06	3	44	2	7650482
Pubmed	Disseminated trichosporonosis in a murine model of chronic granulomatous disease.	NCF1C NCF1B	4.69e-06	3	44	2	12868577
Pubmed	A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.	CACNA1D OTOF	4.69e-06	3	44	2	26568308
Cytoband	12p13	TAS2R14 NOP2	1.74e-03	64	44	2	12p13
Cytoband	11p11.2	MAPK8IP1 ATG13	2.91e-03	83	44	2	11p11.2
Cytoband	7q11.23	NCF1C NCF1B	3.95e-03	97	44	2	7q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr4q32	TMEM144 GUCY1A1	5.97e-03	120	44	2	chr4q32
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	MAPK8IP1 ATG13	9.52e-03	153	44	2	chr11p11
GeneFamily	Calcium voltage-gated channel subunits	CACNA1D CACNB2	7.88e-04	26	29	2	253
Coexpression	NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_DN	RCN1 USP13 ATG13 OPA1 RBM19 PI4KA ZNF292	4.24e-06	399	44	7	M40939
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	USP13 CACNB2 KLHL24 GRIP2 WNK2	1.15e-06	188	44	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	LV\|World / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 ABCB1	2.97e-05	180	44	4	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 WNK2	3.44e-05	187	44	4	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP13 CACNB2 TMEM144 WNK2	3.52e-05	188	44	4	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP13 CACNB2 TMEM144 WNK2	3.52e-05	188	44	4	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 WNK2	3.59e-05	189	44	4	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 WNK2	3.59e-05	189	44	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 WNK2	3.67e-05	190	44	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 WNK2	3.67e-05	190	44	4	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	CACNB2 KLHL24 GRIP2 WNK2	3.74e-05	191	44	4	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	USP13 CACNB2 KLHL24 WNK2	3.82e-05	192	44	4	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NCF1C NCF1B WDFY4 DMXL1	3.98e-05	194	44	4	ff661419b697aef51a53fdeac8d37d870d65f491
Drug	YM-09730-5	CACNA1D CACNB2 ABCB1	1.16e-05	23	44	3	CID000002296
Drug	Clorgyline	CACNB2 STAG2 DMXL1 ZNF292 VCPIP1	1.77e-05	168	44	5	ctd:D003010
Drug	NSC-686960	CACNA1D CACNB2	2.18e-05	4	44	2	CID000192816
Drug	Nilvadipine	CACNA1D CACNB2	3.64e-05	5	44	2	DB06712
Drug	Nisoldipine	CACNA1D CACNB2	3.64e-05	5	44	2	DB00401
Drug	B 874-67	CACNA1D CACNB2	3.64e-05	5	44	2	CID000195466
Drug	methyl beta-aminocrotonate	CACNA1D CACNB2	3.64e-05	5	44	2	CID000084253
Drug	nemadipine-A	CACNA1D CACNB2	3.64e-05	5	44	2	CID002856102
Drug	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one	MAP3K9 PI4KA ABCB1	3.86e-05	34	44	3	ctd:C569670
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; HL60; HG-U133A	MAP3K9 KLHL24 ATG13 RBM19 SOAT1	3.90e-05	198	44	5	1588_UP
Drug	CPU-23	CACNA1D CACNB2	5.45e-05	6	44	2	CID003036051
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1C NCF1B	2.17e-05	5	44	2	DOID:3265 (implicated_via_orthology)
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1C NCF1B	1.42e-04	12	44	2	DOID:7148 (implicated_via_orthology)
Disease	Sinus Node Dysfunction (disorder)	CACNA1D CACNB2	2.25e-04	15	44	2	C0428908
Disease	Deaf Mutism	CACNA1D OTOF	4.06e-04	20	44	2	C4082305
Disease	Deafness, Acquired	CACNA1D OTOF	4.06e-04	20	44	2	C0751068
Disease	Hearing Loss, Extreme	CACNA1D OTOF	4.06e-04	20	44	2	C0086395
Disease	Complete Hearing Loss	CACNA1D OTOF	4.06e-04	20	44	2	C0581883
Disease	Prelingual Deafness	CACNA1D OTOF	4.06e-04	20	44	2	C0011052
Disease	Bilateral Deafness	CACNA1D OTOF	4.06e-04	20	44	2	C3665473
Disease	Deafness	CACNA1D OTOF	6.38e-04	25	44	2	C0011053
Disease	Beta blocking agent use measurement	CACNA1D CACNB2 GUCY1A1	6.63e-04	114	44	3	EFO_0009929
Disease	hypertension, COVID-19	CACNA1D GUCY1A1	7.45e-04	27	44	2	EFO_0000537, MONDO_0100096
Disease	response to angiotensin receptor blocker	CACNA1D CACNB2	9.21e-04	30	44	2	EFO_0010735
Disease	pelvic organ prolapse	CRAT SGK1 CDH9	1.10e-03	136	44	3	EFO_0004710

Protein segments in the cluster

Peptide	Gene	Start	Entry
HDDFVMIDFKPAFSK	ATG13	441	O75143
IFQDTKSFPMHFDEK	ERO1B	346	Q86YB8
VMVFHHFGKDFPKSE	CRAT	411	P43155
GKFAPFEIKEHMVLA	CHAF1A	466	Q13111
VHLMKFSPDGEFFAT	DMXL1	171	Q9Y485
PGMAISFEAKDFLHV	CACNB2	136	Q08289
FTAFLHPEEFEHMKE	RCN1	191	Q15293
KPKGFAFITFMFPEH	RBM19	441	Q9Y4C8
DFIMKLPHKFDTLVG	ABCB1	511	P08183
DMFPEEFDKTSFHKV	GNPTAB	971	Q3T906
PEFMFSINDFKVLKH	EPHX4	226	Q8IUS5
EPDVHFSKKFLNVFM	MAPK8IP1	451	Q9UQF2
DKKGHIIHIDFGFMF	PI4KA	1966	P42356
MATDFAPGFQKKFHE	IPO5	426	O00410
FHKTLKEMFPIEAGA	NCF1B	51	A6NI72
FHKTLKEMFPIEAGA	NCF1C	26	A8MVU1
FSRFMTEPKGKEHDD	OPA1	681	O60313
VFEMDPKSLTGHEFF	KLHL24	26	Q6TFL4
IHFPKDFLSVMLEKG	GSTK1	81	Q9Y2Q3
FFGDKTDFHPLMDQF	DNAAF9	1131	Q5TEA3
MFDPGHFLDKSGNFK	CYP2C18	406	P33260
KVTLHKDPMRHDFGF	GRIP2	941	Q9C0E4
GEFFKDLEAPMDETH	SAMD15	116	Q9P1V8
LMEFGGTPKHFAEAK	OLAH	156	Q9NV23
VMDKDDPPRGHKFFF	CDH9	511	Q9ULB4
ELFIGKMHKTCFFAD	CACNA1D	291	Q01668
IEESGFFEMPKDSFH	MAP3K9	406	P80192
FVFDFHVSPDVMFDK	OTOF	301	Q9HC10
FHDAKFMADIDLDPG	TARS1	641	P26639
MFKDGEPSGHKEFRE	TAS2R14	301	Q9NYV8
LKPFFMKEVGSHFDD	SOAT1	61	P35610
GAKDDFMEIKSHVFF	SGK1	341	O00141
PHTHNMDGFFIAKFK	NOP2	571	P46087
FMDQHPEMDFSKAKF	NUDC	316	Q9Y266
AMLHKDGIEFAFKEP	STAG2	971	Q8N3U4
FVPLKKFDTGDGMFL	TMEM144	26	Q7Z5S9
FKPMGFEVSFLKFLE	ZNF292	2586	O60281
KDHGMVPFIKIFLDD	WDFY4	566	Q6ZS81
AMKLVTKHFPGEFGS	VCPIP1	626	Q96JH7
HKMVTFKFDLDGDAP	WNK2	1211	Q9Y3S1
ESQPKFGHFLEFMDE	XRRA1	766	Q6P2D8
PRMFKAFVSKSHPEF	USP13	426	Q92995
FCFPEMKKDIHHFEF	ZNF816	101	Q0VGE8
LFCKTFPFHFMFDKD	GUCY1A1	281	Q02108