Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EFh	ZZEF1 CIB3 RCN3	3.74e-03	158	37	3	SM00054
Domain	ARM-type_fold	TERB1 LYST PIK3CD TNPO3	4.39e-03	339	37	4	IPR016024
Domain	EF_HAND_2	ZZEF1 CIB3 RCN3	1.06e-02	231	37	3	PS50222
Domain	EF_hand_dom	ZZEF1 CIB3 RCN3	1.08e-02	232	37	3	IPR002048
Domain	-	ZZEF1 CIB3 RCN3	1.48e-02	261	37	3	1.10.238.10
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	ZNF536 TNRC18 MTREX SUPT5H TNPO3	1.19e-05	282	37	5	23667531
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MTREX PQBP1 CCDC174 SUPT5H GARRE1 PPP4R2	3.39e-05	588	37	6	38580884
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZBTB47 CNTN4 SGSM3 BRD2 MYH14 SUPT5H LRRFIP1 PEG3	5.04e-05	1285	37	8	35914814
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ASNSD1 GPATCH4 MTREX PQBP1 RRP1B MYH14 LRRFIP1 PEG3	7.95e-05	1371	37	8	36244648
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MTREX RRP1B MYH14 SUPT5H PPP4R2	9.89e-05	440	37	5	34244565
Pubmed	Human transcription factor protein interaction networks.	ASNSD1 ZNF536 GPATCH4 BRD2 RRP1B MYH14 CCDC174 GARRE1	1.06e-04	1429	37	8	35140242
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	GPATCH4 MTREX RRP1B POLR3E LRRFIP1	1.33e-04	469	37	5	37314180
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	L1TD1 RMDN3 ZNF536 GPATCH4 BRD2 ZZEF1 GARRE1	1.52e-04	1116	37	7	31753913
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	GPATCH4 MTREX BRD2 PQBP1 RRP1B POLR3E SUPT5H	3.76e-04	1294	37	7	30804502
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	MTREX RRP1B SUPT5H LRRFIP1	4.20e-04	332	37	4	25693804
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	GPATCH4 MTREX BRD2 RRP1B SUPT5H	4.31e-04	605	37	5	28977666
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	MTREX BRD2 RRP1B CCDC174	4.54e-04	339	37	4	30415952
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	ASNSD1 GPATCH4 MTREX RRP1B SUPT5H	4.64e-04	615	37	5	31048545
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	GPATCH4 MTREX RRP1B SUPT5H	5.07e-04	349	37	4	25665578
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	ASNSD1 RMDN3 RRP1B SUPT5H TNPO3 PPP4R2	5.26e-04	974	37	6	28675297
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	ASNSD1 MTREX PQBP1 RRP1B	5.75e-04	361	37	4	30344098
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	GPATCH4 MTREX RRP1B HJURP	5.93e-04	364	37	4	24778252
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MTREX BRD2 RRP1B SUPT5H LRRFIP1	6.39e-04	660	37	5	32780723
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MTREX BRD2 PQBP1 RRP1B MYH14 SUPT5H	6.84e-04	1024	37	6	24711643
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	CNTN4 RMDN3 GPATCH4 MYH14 SUPT5H	6.84e-04	670	37	5	22990118
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	L1TD1 SUPT5H UTP14C	8.87e-04	177	37	3	26206133
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PALM3 RMDN3 GPATCH4 MTREX BRD2 PQBP1 RRP1B	8.93e-04	1497	37	7	31527615
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	MTREX BRD2 RRP1B UTP14C	9.33e-04	411	37	4	35182466
Pubmed	Nucleolar proteome dynamics.	GPATCH4 MTREX PQBP1 RRP1B	1.00e-03	419	37	4	15635413
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TNRC18 MTREX PQBP1 CCDC174 TNPO3 PPP4R2	1.01e-03	1103	37	6	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TNRC18 BRD2 ZZEF1 LYST PIK3CD TNPO3	1.02e-03	1105	37	6	35748872
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NLRP12 MYH14 SUPT5H GARRE1 RCN3 PEG3	3.53e-04	1192	37	6	chr19q13
Cytoband	19p13.12	PALM3 CIB3	7.56e-04	50	37	2	19p13.12
Cytoband	19q13.33	MYH14 RCN3	3.34e-03	106	37	2	19q13.33
GeneFamily	EF-hand domain containing	ZZEF1 CIB3 RCN3	2.94e-03	219	24	3	863
Disease	p53 and DNA damage-regulated protein 1 measurement	ASNSD1 NLRP12	8.67e-06	4	36	2	EFO_0803313
Disease	response to atorvastatin, myopathy	ZNF536 GARRE1	1.12e-04	13	36	2	EFO_0004145, EFO_0010124
Disease	Growth Disorders	CNTN4 PQBP1	8.88e-04	36	36	2	C0018273

Protein segments in the cluster

Peptide	Gene	Start	Entry
DFDRDGDHFERVGGQ	CNTN4	541	Q8IWV2
GHGRNRYDEIKEEFD	HJURP	571	Q8NCD3
DFRDLNKDGHLDGSE	RCN3	251	Q96D15
EGHLRAEKEGDEEKR	PALM3	461	A6NDB9
DEKDGGAREAESRAH	GPATCH4	396	Q5T3I0
ELHGFEAAALRDEGE	MYH14	61	Q7Z406
FGDDKDNEREHERER	PEG3	586	Q9GZU2
SDRGHDKSDRDRERG	PQBP1	131	O60828
ERRENFLHGDDGKDE	GARRE1	621	O15063
FGRHIGLDEEFDLED	LYST	2401	Q99698
RDDRVIGDHGKEARF	ASNSD1	536	Q9NWL6
HRDSQKAGERDDDEE	CCDC174	131	Q6PII3
AFGGDQFEEKHAEER	SLC15A2	166	Q16348
DAKHREREAANEAGD	POLR3E	146	Q9NVU0
EGHEVKRLRFDKEGE	PPP4R2	241	Q9NY27
RDHNEEEGEETGLRD	LRRFIP1	496	Q32MZ4
EDEDKGQREKGYHEA	ARHGAP30	796	Q7Z6I6
DELHRGDEQGKREGF	RMDN3	246	Q96TC7
HSRKDGLSDERGRDD	RRP1B	271	Q14684
IGDEEFERFLERHKE	RSAD2	271	Q8WXG1
FERHDDDELGFRKND	SGSM3	491	Q96HU1
RHGGFILDEADVDDE	SUPT5H	71	O00267
EKHRGRAGADEDDKG	BRD2	561	P25440
KAEFDDLQREHGEGS	CENPBD1P	116	B2RD01
ADGDHDGRLSLEDFQ	CIB3	156	Q96Q77
VKGHGRADEDCVDDR	TNRC18	716	O15417
EDEGDSDGERKHQKL	UTP14C	31	Q5TAP6
DLRDGEREHEAAQRK	TRMT61B	46	Q9BVS5
DGLHLVVDENGDFRE	MTREX	326	P42285
ERRGSGELYEHEKDL	PIK3CD	516	O00329
LGREDGLQRHSDEEE	ZBTB47	266	Q9UFB7
GVANDHEEDFELRKE	TNPO3	806	Q9Y5L0
DRKGEEDGLHVGLDE	ZNF536	656	O15090
AEHGDLELDERGDRE	ZZEF1	2421	O43149
HADRIGRGSKAEDED	TERB1	451	Q8NA31
HLEFTERESRKDGED	L1TD1	191	Q5T7N2
FEEQDLRKHGLDGED	NLRP12	476	P59046