Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chondroitin-glucuronate 5-epimerase activity	DSEL DSE	6.40e-06	2	51	2	GO:0047757
GeneOntologyMolecularFunction	racemase and epimerase activity, acting on carbohydrates and derivatives	DSEL DSE	3.47e-04	11	51	2	GO:0016857
GeneOntologyMolecularFunction	racemase and epimerase activity	DSEL DSE	9.53e-04	18	51	2	GO:0016854
GeneOntologyMolecularFunction	antigen binding	LPA IGHV4-39 IGHV3-64D IGHV3-64	1.40e-03	190	51	4	GO:0003823
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	MFSD4A MFSD4B	1.85e-03	25	51	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	MFSD4A MFSD4B	1.85e-03	25	51	2	GO:0015149
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	MFSD4A MFSD4B	2.16e-03	27	51	2	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	MFSD4A MFSD4B	2.48e-03	29	51	2	GO:0051119
HumanPheno	Persistent open anterior fontanelle	RUNX2 CTSK DSE	1.15e-06	8	15	3	HP:0004474
HumanPheno	Hypoplastic inferior ilia	SOX9 RUNX2	4.84e-05	4	15	2	HP:0008821
HumanPheno	Hypoplastic iliac wing	SOX9 RUNX2 CTSK	8.84e-05	31	15	3	HP:0002866
HumanPheno	Spondylolysis	RUNX2 CTSK	1.21e-04	6	15	2	HP:0003304
HumanPheno	Delayed closure of the anterior fontanelle	RUNX2 CTSK DSE	1.28e-04	35	15	3	HP:0001476
HumanPheno	Delayed cranial suture closure	SLC5A5 RUNX2 CTSK DSE	1.49e-04	98	15	4	HP:0000270
HumanPheno	Absent frontal sinuses	RUNX2 CTSK	2.24e-04	8	15	2	HP:0002688
HumanPheno	Abnormal fontanelle morphology	SLC5A5 SOX9 RUNX2 CTSK DSE	2.49e-04	211	15	5	HP:0011328
HumanPheno	Cervical kyphosis	SOX9 DSE	2.88e-04	9	15	2	HP:0002947
Domain	NIDO_dom	TECTA MUC4	6.71e-05	5	49	2	IPR003886
Domain	NIDO	TECTA MUC4	6.71e-05	5	49	2	PS51220
Domain	CAT3	SLC7A2 SLC7A14	6.71e-05	5	49	2	IPR015606
Domain	NIDO	TECTA MUC4	6.71e-05	5	49	2	SM00539
Domain	AA_permease_C	SLC7A2 SLC7A14	6.71e-05	5	49	2	PF13906
Domain	NIDO	TECTA MUC4	6.71e-05	5	49	2	PF06119
Domain	CAT_C	SLC7A2 SLC7A14	6.71e-05	5	49	2	IPR029485
Domain	CUB	ATRNL1 TMPRSS6 CUZD1	3.05e-04	50	49	3	SM00042
Domain	-	ATRNL1 TMPRSS6 CUZD1	3.43e-04	52	49	3	2.60.120.290
Domain	CUB	ATRNL1 TMPRSS6 CUZD1	3.62e-04	53	49	3	PS01180
Domain	CUB_dom	ATRNL1 TMPRSS6 CUZD1	4.49e-04	57	49	3	IPR000859
Domain	AA/rel_permease1	SLC7A2 SLC7A14	5.16e-04	13	49	2	IPR002293
Domain	AA_permease_2	SLC7A2 SLC7A14	5.16e-04	13	49	2	PF13520
Domain	ZP_1	CUZD1 TECTA	6.01e-04	14	49	2	PS00682
Domain	ZP_2	CUZD1 TECTA	6.01e-04	14	49	2	PS51034
Domain	ZP	CUZD1 TECTA	6.93e-04	15	49	2	SM00241
Domain	VWFD	TECTA MUC4	7.90e-04	16	49	2	PS51233
Domain	VWD	TECTA MUC4	7.90e-04	16	49	2	SM00216
Domain	VWF_type-D	TECTA MUC4	7.90e-04	16	49	2	IPR001846
Domain	VWD	TECTA MUC4	7.90e-04	16	49	2	PF00094
Domain	ZP_dom	CUZD1 TECTA	8.94e-04	17	49	2	IPR001507
Domain	Zona_pellucida	CUZD1 TECTA	8.94e-04	17	49	2	PF00100
Domain	MFS	SLC16A4 MFSD4A MFSD4B	1.08e-03	77	49	3	IPR011701
Domain	MFS_1	SLC16A4 MFSD4A MFSD4B	1.08e-03	77	49	3	PF07690
Domain	AA-permease/SLC12A_dom	SLC7A2 SLC7A14	1.51e-03	22	49	2	IPR004841
Domain	AA_permease	SLC7A2 SLC7A14	1.51e-03	22	49	2	PF00324
Domain	Plexin_repeat	ATRNL1 PLXNA2	3.18e-03	32	49	2	IPR002165
Domain	PSI	ATRNL1 PLXNA2	3.18e-03	32	49	2	PF01437
Domain	EGF	ATRNL1 TECTA MUC4 TENM2	3.32e-03	235	49	4	SM00181
Domain	EGF-like_dom	ATRNL1 TECTA MUC4 TENM2	4.08e-03	249	49	4	IPR000742
Domain	MFS_dom	SLC16A4 MFSD4A MFSD4B	5.23e-03	134	49	3	IPR020846
Domain	PSI	ATRNL1 PLXNA2	5.95e-03	44	49	2	IPR016201
Domain	PSI	ATRNL1 PLXNA2	6.48e-03	46	49	2	SM00423
Domain	CUB	ATRNL1 CUZD1	7.33e-03	49	49	2	PF00431
Domain	Kelch-typ_b-propeller	ATRNL1 KLHL23	9.16e-03	55	49	2	IPR015915
Pathway	REACTOME_CD22_MEDIATED_BCR_REGULATION	IGHV4-39 IGHV3-64D IGHV3-64	1.03e-04	35	37	3	MM17219
Pathway	REACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION	IGHV4-39 IGHV3-64D IGHV3-64	1.43e-04	39	37	3	MM17212
Pathway	REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION	IGHV4-39 IGHV3-64D IGHV3-64	2.19e-04	45	37	3	MM14912
Pathway	REACTOME_FCGR_ACTIVATION	IGHV4-39 IGHV3-64D IGHV3-64	2.65e-04	48	37	3	MM17214
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	DSEL DSE	2.98e-04	10	37	2	MM14801
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	IGHV4-39 IGHV3-64D IGHV3-64	3.56e-04	53	37	3	MM15716
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	DSEL DSE	3.63e-04	11	37	2	M27105
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	IGHV4-39 IGHV3-64D IGHV3-64	3.76e-04	54	37	3	MM14655
Pathway	REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS	IGHV4-39 IGHV3-64D IGHV3-64	4.19e-04	56	37	3	MM14815
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	IGHV4-39 IGHV3-64D IGHV3-64	4.65e-04	58	37	3	MM14914
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	IGHV4-39 IGHV3-64D IGHV3-64	5.14e-04	60	37	3	MM14913
Pathway	REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS	IGHV4-39 IGHV3-64D IGHV3-64	5.14e-04	60	37	3	MM14872
Pathway	REACTOME_COMPLEMENT_CASCADE	IGHV4-39 IGHV3-64D IGHV3-64	1.37e-03	84	37	3	MM14653
Pubmed	The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.	SOX9 RUNX2 CTSK	1.13e-06	14	52	3	11792318
Pubmed	PlexinA2 mediates osteoblast differentiation via regulation of Runx2.	RUNX2 PLXNA2	2.19e-06	2	52	2	22095611
Pubmed	Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2.	SOX9 RUNX2	2.19e-06	2	52	2	31779679
Pubmed	Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.	SOX9 RUNX2	2.19e-06	2	52	2	26777999
Pubmed	In vitro osteogenic potential of human mesenchymal stem cells is predicted by Runx2/Sox9 ratio.	SOX9 RUNX2	2.19e-06	2	52	2	24980654
Pubmed	SOX9 determines RUNX2 transactivity by directing intracellular degradation.	SOX9 RUNX2	2.19e-06	2	52	2	20593410
Pubmed	A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.	SLC7A2 SLC7A14	2.19e-06	2	52	2	22787143
Pubmed	Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells.	DSEL DSE	2.19e-06	2	52	2	23843960
Pubmed	Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.	DSEL DSE	2.19e-06	2	52	2	16505484
Pubmed	Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate.	DSEL DSE	2.19e-06	2	52	2	19188366
Pubmed	Biological functions of iduronic acid in chondroitin/dermatan sulfate.	DSEL DSE	2.19e-06	2	52	2	23441919
Pubmed	Mechanical load regulates bone growth via periosteal Osteocrin.	SOX9 RUNX2 CTSK	4.76e-06	22	52	3	34260913
Pubmed	Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.	IGHV4-39 IGHV3-64D IGHV3-64	4.76e-06	22	52	3	2499654
Pubmed	Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.	SOX9 RUNX2 CTSK	6.24e-06	24	52	3	32186512
Pubmed	Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.	SOX9 RUNX2	6.57e-06	3	52	2	19306868
Pubmed	Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors.	SOX9 RUNX2	6.57e-06	3	52	2	21078438
Pubmed	An immunohistochemistry study of Sox9, Runx2, and Osterix expression in the mandibular cartilages of newborn mouse.	SOX9 RUNX2	6.57e-06	3	52	2	23762831
Pubmed	β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.	SOX9 RUNX2 CTSK	8.99e-06	27	52	3	27621061
Pubmed	Cyclic tensile strain facilitates the ossification of ligamentum flavum through β-catenin signaling pathway: in vitro analysis.	SOX9 RUNX2	1.31e-05	4	52	2	22158061
Pubmed	SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.	SOX9 RUNX2	1.31e-05	4	52	2	22072985
Pubmed	Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area.	SOX9 RUNX2	1.31e-05	4	52	2	9636074
Pubmed	Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes.	SOX9 RUNX2	1.31e-05	4	52	2	20196777
Pubmed	Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.	SOX9 RUNX2	1.31e-05	4	52	2	27238423
Pubmed	Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis.	SOX9 RUNX2 CTSK	1.38e-05	31	52	3	36127325
Pubmed	Epigenetic regulation of Tbx18 gene expression during endochondral bone formation.	SOX9 RUNX2	2.19e-05	5	52	2	25380565
Pubmed	Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.	SOX9 RUNX2	2.19e-05	5	52	2	25594183
Pubmed	MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development.	SOX9 RUNX2	2.19e-05	5	52	2	23326237
Pubmed	Transcriptional mechanisms in osteoblast differentiation and bone formation.	SOX9 RUNX2	2.19e-05	5	52	2	12902164
Pubmed	A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones.	SOX9 RUNX2	2.19e-05	5	52	2	25419849
Pubmed	Possible roles of Runx1 and Sox9 in incipient intramembranous ossification.	SOX9 RUNX2	3.28e-05	6	52	2	15355562
Pubmed	Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development.	SOX9 RUNX2	3.28e-05	6	52	2	15389629
Pubmed	Effects of reduced connexin43 function on skull development in the Cx43I130T/+ mutant mouse that models oculodentodigital dysplasia.	SOX9 RUNX2	3.28e-05	6	52	2	32320893
Pubmed	The essential requirement for Runx1 in the development of the sternum.	SOX9 RUNX2	3.28e-05	6	52	2	20152828
Pubmed	An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis.	SOX9 RUNX2	3.28e-05	6	52	2	18624832
Pubmed	Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development.	SOX9 RUNX2	3.28e-05	6	52	2	22223437
Pubmed	Distinct function of P63 isoforms during embryonic skeletal development.	SOX9 RUNX2	4.58e-05	7	52	2	23481305
Pubmed	Downregulation of SOX9 expression in developing entheses adjacent to intramembranous bone.	SOX9 RUNX2	4.58e-05	7	52	2	38728328
Pubmed	Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest.	SOX9 RUNX2	4.58e-05	7	52	2	12878728
Pubmed	Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis.	DSEL DSE	4.58e-05	7	52	2	26488883
Pubmed	Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice.	SOX9 RUNX2	4.58e-05	7	52	2	31064775
Pubmed	A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.	SOX9 RUNX2	4.58e-05	7	52	2	38058151
Pubmed	Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.	RUNX2 CTSK	4.58e-05	7	52	2	20200944
Pubmed	Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.	LPA TMPRSS6	4.58e-05	7	52	2	21149283
Pubmed	Runx1 and Runx2 cooperate during sternal morphogenesis.	SOX9 RUNX2	4.58e-05	7	52	2	20181744
Pubmed	Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1.	SOX9 RUNX2	4.58e-05	7	52	2	29929043
Pubmed	Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog.	SOX9 RUNX2	6.10e-05	8	52	2	15107406
Pubmed	Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice.	SOX9 RUNX2	6.10e-05	8	52	2	30424580
Pubmed	Mice with an anterior cleft of the palate survive neonatal lethality.	SOX9 RUNX2	6.10e-05	8	52	2	18393307
Pubmed	Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects.	SOX9 RUNX2	6.10e-05	8	52	2	21807129
Pubmed	Tissue interaction is required for glenoid fossa development during temporomandibular joint formation.	SOX9 RUNX2	6.10e-05	8	52	2	21953591
Pubmed	Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model.	SOX9 RUNX2	6.10e-05	8	52	2	23383321
Pubmed	Chondrogenic potential of mouse calvarial mesenchyme.	SOX9 RUNX2	6.10e-05	8	52	2	15872058
Pubmed	Augmented Indian hedgehog signaling in cranial neural crest cells leads to craniofacial abnormalities and dysplastic temporomandibular joint in mice.	SOX9 RUNX2	6.10e-05	8	52	2	26553654
Pubmed	Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.	SOX9 RUNX2	6.10e-05	8	52	2	24917674
Pubmed	Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme.	SOX9 RUNX2	6.10e-05	8	52	2	28069589
Pubmed	Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis.	SOX9 RUNX2	6.10e-05	8	52	2	21256960
Pubmed	p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development.	SOX9 RUNX2	6.10e-05	8	52	2	12086466
Pubmed	Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.	SOX9 RUNX2	6.10e-05	8	52	2	20025746
Pubmed	A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration.	SOX9 RUNX2	6.10e-05	8	52	2	31949165
Pubmed	Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.	SOX9 RUNX2	6.10e-05	8	52	2	31439548
Pubmed	Dominance of SOX9 function over RUNX2 during skeletogenesis.	SOX9 RUNX2	6.10e-05	8	52	2	17142326
Pubmed	Ihh signaling regulates mandibular symphysis development and growth.	SOX9 RUNX2	7.84e-05	9	52	2	21297010
Pubmed	Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.	SOX9 RUNX2	7.84e-05	9	52	2	30008325
Pubmed	COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring.	SOX9 RUNX2	7.84e-05	9	52	2	28959031
Pubmed	G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development.	SOX9 RUNX2	7.84e-05	9	52	2	32344102
Pubmed	Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency.	SOX9 RUNX2	7.84e-05	9	52	2	22337375
Pubmed	Finding the Unicorn, a New Mouse Model of Midfacial Clefting.	SOX9 RUNX2	7.84e-05	9	52	2	31940751
Pubmed	Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development.	SOX9 RUNX2	7.84e-05	9	52	2	20980404
Pubmed	Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification.	SOX9 RUNX2	7.84e-05	9	52	2	22290230
Pubmed	TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development.	SOX9 RUNX2	7.84e-05	9	52	2	18684439
Pubmed	Dental niche cells directly contribute to tooth reconstitution and morphogenesis.	SOX9 RUNX2	7.84e-05	9	52	2	36476878
Pubmed	FGF9 can induce endochondral ossification in cranial mesenchyme.	SOX9 RUNX2	7.84e-05	9	52	2	16504022
Pubmed	The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development.	SOX9 RUNX2	7.84e-05	9	52	2	23792766
Pubmed	Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects.	SOX9 RUNX2	7.84e-05	9	52	2	30228104
Pubmed	ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.	SOX9 RUNX2 PLXNA2	9.66e-05	59	52	3	31924792
Pubmed	Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling.	SOX9 RUNX2	9.79e-05	10	52	2	24551245
Pubmed	Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.	SOX9 RUNX2	9.79e-05	10	52	2	15096597
Pubmed	Med23 Regulates Sox9 Expression during Craniofacial Development.	SOX9 RUNX2	9.79e-05	10	52	2	33155500
Pubmed	PRMT5 is necessary to form distinct cartilage identities in the knee and long bone.	SOX9 RUNX2	9.79e-05	10	52	2	31442442
Pubmed	Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation.	SOX9 RUNX2	9.79e-05	10	52	2	26058470
Pubmed	The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development.	SOX9 PLXNA2	9.79e-05	10	52	2	22300732
Pubmed	A unique stylopod patterning mechanism by Shox2-controlled osteogenesis.	SOX9 RUNX2	9.79e-05	10	52	2	27287812
Pubmed	The -KTS splice variant of WT1 is essential for ovarian determination in mice.	SOX9 RUNX2	9.79e-05	10	52	2	37917714
Pubmed	Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification.	SOX9 RUNX2	9.79e-05	10	52	2	19725955
Pubmed	Trps1 is necessary for normal temporomandibular joint development.	SOX9 RUNX2	9.79e-05	10	52	2	22427063
Pubmed	Foxp1/2/4 regulate endochondral ossification as a suppresser complex.	SOX9 RUNX2	1.20e-04	11	52	2	25527076
Pubmed	The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen.	SOX9 RUNX2	1.20e-04	11	52	2	10572046
Pubmed	Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates.	SOX9 RUNX2	1.20e-04	11	52	2	21228004
Pubmed	Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification.	SOX9 RUNX2	1.20e-04	11	52	2	23095887
Pubmed	Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.	SOX9 RUNX2	1.20e-04	11	52	2	20534695
Pubmed	SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes.	SOX9 RUNX2	1.20e-04	11	52	2	28983104
Pubmed	Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.	SOX9 RUNX2	1.20e-04	11	52	2	15866163
Pubmed	Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice.	SOX9 RUNX2	1.20e-04	11	52	2	18514492
Pubmed	Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development.	SOX9 RUNX2	1.20e-04	11	52	2	19501582
Pubmed	JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.	SOX9 RUNX2	1.20e-04	11	52	2	25587042
Pubmed	Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.	SOX9 RUNX2	1.20e-04	11	52	2	19356224
Pubmed	Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice.	SOX9 RUNX2	1.20e-04	11	52	2	24248941
Pubmed	miRNAs control tracheal chondrocyte differentiation.	SOX9 RUNX2	1.43e-04	12	52	2	21945074
Pubmed	The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties.	SOX9 RUNX2	1.43e-04	12	52	2	24080509
Pubmed	Regulation of bone formation and remodeling by G-protein-coupled receptor 48.	SOX9 RUNX2	1.43e-04	12	52	2	19605502
Cytoband	6q22	MFSD4B DSE	3.51e-05	8	52	2	6q22
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	OR1J4 OR1L3 OR1J2	5.27e-04	138	52	3	chr9q33
Cytoband	9q34.11	OR1J4 OR1J2	1.67e-03	53	52	2	9q34.11
GeneFamily	Olfactory receptors, family 1	OR1J4 OR1L3 OR1J2	4.76e-05	40	32	3	147
GeneFamily	Solute carriers	SLC5A5 SLC7A2 SLC16A4 SLC7A14	4.97e-03	395	32	4	752
ToppCell	Club_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	SLC5A5 TMEM130 KLHL23 MFSD4A MARVELD3 MUC4	3.40e-08	161	52	6	bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAOX HOXD3 MFSD4A PLXNA2 BOLL	1.41e-06	165	52	5	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 GPLD1 SLC7A2 TMPRSS6 ATP9A	2.35e-06	183	52	5	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAQR9 SOX9 PTCHD1 LPA TMPRSS6	2.47e-06	185	52	5	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 SLC7A2 LIPM TMPRSS6 MARVELD3	2.54e-06	186	52	5	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 SLC7A2 LIPM TMPRSS6 MARVELD3	2.54e-06	186	52	5	de88fafac51049ec1920695844d8ce8057940272
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 SLC7A2 LIPM TMPRSS6 MARVELD3	2.54e-06	186	52	5	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MANEA RUNX2 IGHV4-39 IGHV3-64D IGHV3-64	2.82e-06	190	52	5	79ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MANEA RUNX2 IGHV4-39 IGHV3-64D IGHV3-64	2.82e-06	190	52	5	18762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	PTCHD1 TMEM130 HTR7 MFSD4A TENM2	2.97e-06	192	52	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SLC5A5 KLHL23 MFSD4A RUNX2 MUC4	3.04e-06	193	52	5	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	SLC5A5 KLHL23 MFSD4A RUNX2 MUC4	3.04e-06	193	52	5	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	Epithelial_cells-Club_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	SLC5A5 KLHL23 MFSD4A RUNX2 MUC4	3.20e-06	195	52	5	b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MARVELD3 RUNX2 MUC4 PLXNA2	2.69e-05	148	52	4	9fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCell	AT1-AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SOX9 TMPRSS6 MGARP MUC4	3.48e-05	158	52	4	3bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCell	Club_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	TMEM130 MFSD4A RUNX2 MUC4	3.65e-05	160	52	4	b261a3a49c850d92bc9e04fc3527c752dfe37a1a
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PAQR9 SLC7A2 TECTA MGARP	4.21e-05	166	52	4	4d63c758d46e73311b864148c646bf081498dee7
ToppCell	facs-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 HTR7 TMPRSS6 KLHL23	4.21e-05	166	52	4	8d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PAQR9 SLC7A2 TECTA MGARP	4.21e-05	166	52	4	4160ccf9291072a6e2782f9ad141bc9a9747f3ad
ToppCell	facs-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 HTR7 TMPRSS6 KLHL23	4.21e-05	166	52	4	f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCell	facs-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 HTR7 TMPRSS6 KLHL23	4.21e-05	166	52	4	a5074c96c6561273029aceb93402a7e038140f50
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 PCDHB15 TENM2 SLC7A14	4.42e-05	168	52	4	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 PCDHB15 TENM2 SLC7A14	4.42e-05	168	52	4	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SOX9 SLC7A2 SLC16A4 DSEL	4.52e-05	169	52	4	58e22f9119240664515fe91ca53812611a8f17d6
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HTR7 LIPM TRPV2 RUNX2	4.62e-05	170	52	4	3cbeea6bfa500928c413b1c6129f6dedc769cd1e
ToppCell	facs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 MFSD4A MARVELD3 ATP9A	4.95e-05	173	52	4	295bfe1efa648173c2d5981025bc61c576baf53f
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 MFSD4A MARVELD3 MGARP	5.06e-05	174	52	4	cdfc50e5383c8670ce5109736aff36406f46c03d
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	PTCHD1 MFSD4A RUNX2 MUC4	5.29e-05	176	52	4	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TECTA DSEL OR1L3 OR1J2	5.41e-05	177	52	4	57033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Pre-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RIPOR2 OR13A1 IGHV4-39 IGHV3-64D	5.53e-05	178	52	4	34ef4d36ddfb1cdeaaaf5d952e1ad6dc2785ce1e
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TREX1 PTCHD1 HTR7 TRPV2	5.65e-05	179	52	4	33ed9270d257895ff3b40df2c1af878119c9f492
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TREX1 RUNX2 MGARP CTSK	5.77e-05	180	52	4	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 SLC7A2 TMPRSS6 MARVELD3	5.90e-05	181	52	4	3fd16229a63de0971db5d48860c01173d7db518f
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SLC7A2 TMPRSS6 ATP9A	6.03e-05	182	52	4	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 MFSD4A MUC4 TENM2	6.03e-05	182	52	4	b8be66a867ea1bbae0820b26dbd55b68611f5ad5
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TMEM130 HTR7 MFSD4A TENM2	6.03e-05	182	52	4	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SLC7A2 TMPRSS6 ATP9A	6.03e-05	182	52	4	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SLC7A2 TMPRSS6 ATP9A	6.03e-05	182	52	4	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 MFSD4A MUC4 TENM2	6.03e-05	182	52	4	cb488f9a9b200e2557335ccf22535cd247512cdc
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 MFSD4A MARVELD3 MGARP	6.29e-05	184	52	4	1e54fd372c6e6a298f427b807c14cc49aaaffe80
ToppCell	10x5'-Liver-Lymphocytic_B_plasma-Plasma_cells\|Liver / Manually curated celltypes from each tissue	MANEA IGHV4-39 IGHV3-64D IGHV3-64	6.29e-05	184	52	4	6f70d8f8ab8362d51f8a58735d42223e06566397
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A2 CUZD1 RUNX2 CTSK	6.56e-05	186	52	4	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPLD1 PTCHD1 ATP9A TMEM255B	6.56e-05	186	52	4	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	facs-BAT-Fat-24m-Epithelial-Epcam+\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SOX9 MARVELD3 MUC4	6.56e-05	186	52	4	b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A2 CUZD1 RUNX2 CTSK	6.56e-05	186	52	4	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	mild_COVID-19-Plasmablast\|mild_COVID-19 / disease group, cell group and cell class (v2)	GPLD1 MANEA IGHV3-64D IGHV3-64	6.56e-05	186	52	4	a639d2183b85b1be6e6da2b2e112aec5149d5bcd
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SOX9 SLC7A2 TMPRSS6	6.56e-05	186	52	4	ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCell	facs-SCAT-Fat-3m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 SOX9 SLC7A2 MARVELD3	6.69e-05	187	52	4	08f2ecce3c08f35d995187b21bb7407a99dee4c2
ToppCell	facs-SCAT-Fat-3m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 SOX9 SLC7A2 MARVELD3	6.69e-05	187	52	4	939a068ac0913b9eeb5da4a9cb267d51cb711999
ToppCell	facs-SCAT-Fat-3m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 SOX9 SLC7A2 MARVELD3	6.69e-05	187	52	4	e02e7f608506b9a48384f07727944f1cb8f7c575
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-9\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	HTR7 TENM2 ARSI DSE	6.69e-05	187	52	4	f002ff1a7cb7577f28acff008bc2aa561ac1a4bf
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	TMEM130 MFSD4A RUNX2 MUC4	7.12e-05	190	52	4	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PAQR9 TMEM130 TENM2 SLC7A14	7.12e-05	190	52	4	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	PBMC-Severe-cDC_2\|Severe / Compartment, Disease Groups and Clusters	SLC5A5 MARVELD3 ATP9A	7.23e-05	69	52	3	0fab02d29408415d3aa1f42a55a2e37b458c4030
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	PTCHD1 TMEM130 HTR7 TENM2	7.27e-05	191	52	4	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	PTCHD1 TMEM130 HTR7 TENM2	7.27e-05	191	52	4	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SOX9 SLC7A2 TMPRSS6	7.41e-05	192	52	4	d2161842a38146261847fc9061ba9322e0f087e0
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SOX9 SLC7A2 TMPRSS6	7.41e-05	192	52	4	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX9 PTCHD1 LPA TMPRSS6	7.41e-05	192	52	4	d6ea34391c3f730684b82e912d9cf55e928b3311
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	TMEM130 MFSD4A TENM2 SLC7A14	7.56e-05	193	52	4	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 LIPM MARVELD3 MUC4	7.72e-05	194	52	4	0ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 SOX9 SLC7A2 MARVELD3	7.72e-05	194	52	4	715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	PTCHD1 MFSD4A ATP9A MUC4	8.19e-05	197	52	4	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC5A5 TMEM130 RUNX2 MUC4	8.35e-05	198	52	4	fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell	distal-3-Epithelial-Mucous\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC5A5 SOX9 MARVELD3 MUC4	8.51e-05	199	52	4	64dc8a9b25cd52935bd3f956b5c65d2fd1bf4bf5
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MGARP TMEM255B BOLL	1.59e-04	90	52	3	a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MGARP TMEM255B BOLL	1.59e-04	90	52	3	ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Solid_Pattern_Predominant_Adenocarcinoma-1\|TCGA-Lung / Sample_Type by Project: Shred V9	SLC5A5 PAQR9 NR1H4	3.28e-04	115	52	3	891a2c68472c2a633fc1864a9c3debc3b5ae1b77
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	HTR7 RUNX2 OR1J4	4.39e-04	127	52	3	c4809d8502f460370f824719d69b13b400a2b202
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HTR7 LIPM TRPV2	4.49e-04	128	52	3	cfc73cb803ba50a4a8709e19e70e1e399118c849
ToppCell	LPS_only-Myeloid-Dendritic_cells-pDC\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMEM130 RUNX2 BOLL	5.24e-04	135	52	3	0afe232aa1a1e6c37a5b3183b67d7fa07e0ea791
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM130 CATSPERG TENM2	5.47e-04	137	52	3	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM130 CATSPERG TENM2	5.47e-04	137	52	3	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HTR7 TECTA TMEM255B	5.47e-04	137	52	3	5cb84392e4483f50e09fb7395e2ec98f3eb6ecf3
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-3\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	ATRNL1 MANEA MFSD4B	5.47e-04	137	52	3	a1e34ebbeda3d5a4f14917282d44fcb4dcbf3133
ToppCell	TCGA-Bile_Duct\|World / Sample_Type by Project: Shred V9	PAQR9 LPA TMPRSS6	5.83e-04	140	52	3	ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX9 ATRNL1 TECTA	6.20e-04	143	52	3	92ddc3e3f6ba78dd9daeb272c12503ec2650a874
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175\|Adult / Lineage, Cell type, age group and donor	SOX9 PTCHD1 MUC4	7.12e-04	150	52	3	b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX9 SLC7A2 TMPRSS6	7.54e-04	153	52	3	95b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX9 SLC7A2 TMPRSS6	7.54e-04	153	52	3	b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX9 SLC7A2 TMPRSS6	7.54e-04	153	52	3	3ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 MGARP ZFP62	7.69e-04	154	52	3	2d98bb7a784fc3215e0d4a1670d662e5df4716c3
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SLC7A2 TMPRSS6	7.69e-04	154	52	3	a5289000597068ee8d559f89bce7bce31f35dd57
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 MGARP ZFP62	7.69e-04	154	52	3	0dec222101530f1727184dbb7c03969d3884f111
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HTR7 TECTA ARSI	7.83e-04	155	52	3	cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 SLC7A2 TMPRSS6	7.98e-04	156	52	3	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX9 SLC7A2 TMPRSS6	8.13e-04	157	52	3	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX9 SLC7A2 TMPRSS6	8.13e-04	157	52	3	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX9 SLC7A2 TMPRSS6	8.13e-04	157	52	3	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A4 TMPRSS6 CUZD1	8.28e-04	158	52	3	12661763d1c309106801cb710c04cd2b62d16cba
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC7A2 RUNX2 CTSK	8.28e-04	158	52	3	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A4 TMPRSS6 CUZD1	8.28e-04	158	52	3	e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MANEA RUNX2 DSEL	8.28e-04	158	52	3	74aa4f75307575ac3b2b1aa9f727753692f88742
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A4 TMPRSS6 CUZD1	8.28e-04	158	52	3	0792c39e6fc0745095af7812de2d50949540d60f
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 TENM2 PLXNA2	8.28e-04	158	52	3	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 TENM2 PLXNA2	8.28e-04	158	52	3	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	COVID-19-kidney-Plasma\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MANEA IGHV4-39 IGHV3-64D	8.58e-04	160	52	3	f8d9e459976e711e9ad39ea2b6173140c0589d6e
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	MANEA RUNX2 DSEL	8.74e-04	161	52	3	58381131e651744b5141b202f9d6063f55432db5
ToppCell	Adult-Immune-mast_cell\|Adult / Lineage, Cell type, age group and donor	SLC5A5 TMPRSS6 SLC7A14	8.74e-04	161	52	3	44f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAQR9 PTCHD1 TMEM130	8.90e-04	162	52	3	ca1014e32996f777bff021830ce9a7cf4acf58d5
Disease	cholangiocarcinoma (biomarker_via_orthology)	MUC4 NR1H4	2.26e-04	13	51	2	DOID:4947 (biomarker_via_orthology)
Disease	Disproportionate short stature	SOX9 RUNX2 CTSK	3.25e-04	77	51	3	C0878659
Disease	otitis media (biomarker_via_orthology)	MUC4 CTSK	3.92e-04	17	51	2	DOID:10754 (biomarker_via_orthology)
Disease	Autosomal dominant nonsyndromic hearing loss	RIPOR2 TECTA	1.15e-03	29	51	2	cv:C5779548
Disease	Huntington disease, disease progression measurement	ATRNL1 TENM2	1.24e-03	30	51	2	EFO_0008336, MONDO_0007739

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASLTSFQFYSKGVYY	CTSK	251	P43235
QNQLVYYFTGTYTTL	CATSPERG	311	Q6ZRH7
LQSYGSVSYTGYRAS	C2orf78	226	A6NCI8
TFLGSLTGNVDYYTY	ARSI	166	Q5FYB1
GTMYLTTSTGYPYTY	BOLL	126	Q8N9W6
TGSAYLYTYVTVGEL	SLC7A2	96	P52569
ISSSSYYSNLGFYPQ	NR1H4	71	Q96RI1
TGRGTTFYQEYETFY	MUC4	4406	Q99102
SVVSLYYGSIFGQYL	OR1J2	246	Q8NGS2
EYVSAISSNGGSTYY	IGHV3-64	66	A0A075B6Q5
TDGLTGAYSAFVYSY	MFSD4A	321	Q8N468
YYVGYSQGTTMGFIA	LIPM	181	Q5VYY2
ASYVYNGYSVVFVGT	PLXNA2	436	O75051
IGSIYYSGSTYYNPS	IGHV4-39	76	P01824
YEGVAYGSYTTRSLF	DSE	256	Q9UL01
YVSAISSNGGSTYYA	IGHV3-64D	66	A0A0J9YX35
LYQGFLIIGYSTIYT	ATP9A	871	O75110
GYGYSKTTDTYGYST	HOXD3	31	P31249
TGTNGEISYSLYYSS	PCDHB15	271	Q9Y5E8
YTYFATNGFTYGSSH	MANEA	321	Q5SRI9
YVGAEVTYGSYVFSF	MFSD4B	241	Q5TF39
LDYASISYYGFGSTV	PAQR9	156	Q6ZVX9
SVVSLYYGTIIGLYF	OR1J4	246	Q8NGS1
YVTGGYSYSKGTYLQ	KLHL23	511	Q8NBE8
YHYGQSYRGTYSTTV	LPA	1056	P08519
IFGYSAIYGYTSSIQ	ATRNL1	431	Q5VV63
VSAGGYYAYKTVTSD	MGARP	56	Q8TDB4
YTGITSLGGIYYYQF	MARVELD3	226	Q96A59
YANSYRGFSASYTSI	CUZD1	251	Q86UP6
GVAYGSYTAKSVTQY	DSEL	276	Q8IZU8
TAVFYAYISPVSGYS	OR13A1	271	Q8NGR1
PYTRGSYSYVAVGST	PAOX	431	Q6QHF9
FYGSISYVYLQPLSS	OR1L3	251	Q8NH93
STPYLYYGTSSGSYQ	RUNX2	441	Q13950
FYSSGVGYLYDVYQT	TMEM255B	126	Q8WV15
YVLSFYGSSLVFTGY	PTCHD1	416	Q96NR3
YGSSLVFTGYIENNY	PTCHD1	421	Q96NR3
VSLVTGEYLYNFTYS	TENM2	1606	Q9NT68
YYSHAAGQGTGLYST	SOX9	451	P48436
VVTVFQYYSYFTSHG	RIPOR2	881	Q9Y4F9
DFGYTIYSTAVAFYI	HTR7	236	P34969
TGSAYTYSYVTVGEF	SLC7A14	116	Q8TBB6
VSDGSYTFTLFNYYE	TECTA	171	O75443
AVGYYIYVTFLGYSA	UNC50	201	Q53HI1
YTQTYNGSFYFSGIC	SLC16A4	451	O15374
ISYLYYGALGTLTTV	SLC5A5	526	Q92911
FDVQTGSSYIYYVSS	SPPL2A	426	Q8TCT8
GSSYIYYVSSTVAYA	SPPL2A	431	Q8TCT8
SEQLTYKGAVYVYFG	GPLD1	476	P80108
LYYTRGFQHTGIYSV	TRPV2	511	Q9Y5S1
IYVGSYSGTSQKRTY	ZFP62	871	Q8NB50
DSVVYYNYSIIGTFT	TMEM130	191	Q8N3G9
SYSLGSIYTRLYGQS	TREX1	176	Q9NSU2
LGTYYNSSSVYSFGE	TMPRSS6	131	Q8IU80