Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycosylceramidase activity	GBA3 LCT	8.88e-06	2	60	2	GO:0017042
GeneOntologyMolecularFunction	glucosylceramidase activity	GBA3 LCT	5.31e-05	4	60	2	GO:0004348
GeneOntologyMolecularFunction	dopamine receptor binding	DRD1 PTPN11 GNA12	6.38e-05	26	60	3	GO:0050780
GeneOntologyMolecularFunction	galactosylceramidase activity	GBA3 LCT	8.83e-05	5	60	2	GO:0004336
GeneOntologyMolecularFunction	phospholipase C activity	NOTUM CASR PLCB4	8.91e-05	29	60	3	GO:0004629
GeneOntologyMolecularFunction	beta-glucosidase activity	GBA3 LCT	1.32e-04	6	60	2	GO:0008422
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	NOTUM GDPD3 CASR PLCB4	2.07e-04	97	60	4	GO:0008081
GeneOntologyMolecularFunction	phospholipase activity	NOTUM GDPD3 CASR PLCB4	3.84e-04	114	60	4	GO:0004620
GeneOntologyMolecularFunction	protein phosphatase binding	DRD1 IKBKE TBK1 GNA12 CEACAM1	4.19e-04	210	60	5	GO:0019903
GeneOntologyMolecularFunction	lipase activity	NOTUM GDPD3 CASR PLCB4	7.89e-04	138	60	4	GO:0016298
GeneOntologyMolecularFunction	glucosidase activity	GBA3 LCT	9.09e-04	15	60	2	GO:0015926
GeneOntologyMolecularFunction	phosphatase binding	DRD1 IKBKE TBK1 GNA12 CEACAM1	1.17e-03	264	60	5	GO:0019902
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH2 DNAH9	1.32e-03	18	60	2	GO:0008569
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	CASR PLCB4	2.75e-03	26	60	2	GO:0004435
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH2 DNAH9	3.19e-03	28	60	2	GO:0051959
Domain	Glyco_hydro_1_N_CS	GBA3 LCT	6.06e-05	4	60	2	IPR033132
Domain	Glyco_hydro_1_AS	GBA3 LCT	6.06e-05	4	60	2	IPR018120
Domain	GLYCOSYL_HYDROL_F1_2	GBA3 LCT	1.01e-04	5	60	2	PS00653
Domain	GLYCOSYL_HYDROL_F1_1	GBA3 LCT	1.01e-04	5	60	2	PS00572
Domain	Glyco_hydro_1	GBA3 LCT	1.01e-04	5	60	2	PF00232
Domain	Glyco_hydro_1	GBA3 LCT	1.01e-04	5	60	2	IPR001360
Domain	DHC_N1	DNAH2 DNAH9	2.81e-04	8	60	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH2 DNAH9	2.81e-04	8	60	2	IPR013594
Domain	R3H	R3HCC1 YTHDC2	3.60e-04	9	60	2	SM00393
Domain	R3H	R3HCC1 YTHDC2	5.48e-04	11	60	2	PS51061
Domain	R3H	R3HCC1 YTHDC2	5.48e-04	11	60	2	PF01424
Domain	-	R3HCC1 YTHDC2	5.48e-04	11	60	2	3.30.1370.50
Domain	R3H_dom	R3HCC1 YTHDC2	5.48e-04	11	60	2	IPR001374
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH9	9.01e-04	14	60	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH9	9.01e-04	14	60	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH9	9.01e-04	14	60	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH9	9.01e-04	14	60	2	PF08393
Domain	MT	DNAH2 DNAH9	9.01e-04	14	60	2	PF12777
Domain	AAA_8	DNAH2 DNAH9	9.01e-04	14	60	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH9	9.01e-04	14	60	2	IPR011704
Domain	AAA_5	DNAH2 DNAH9	9.01e-04	14	60	2	PF07728
Domain	DHC_fam	DNAH2 DNAH9	1.04e-03	15	60	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH9	1.04e-03	15	60	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH9	1.04e-03	15	60	2	PF03028
Domain	DUF1605	YTHDC2 DHX34	1.34e-03	17	60	2	IPR011709
Domain	OB_NTP_bind	YTHDC2 DHX34	1.34e-03	17	60	2	PF07717
Domain	HA2	YTHDC2 DHX34	1.50e-03	18	60	2	SM00847
Domain	HA2	YTHDC2 DHX34	1.50e-03	18	60	2	PF04408
Domain	Helicase-assoc_dom	YTHDC2 DHX34	1.50e-03	18	60	2	IPR007502
Domain	-	GDPD3 PLCB4	2.90e-03	25	60	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	GDPD3 PLCB4	2.90e-03	25	60	2	IPR017946
Domain	-	GBA3 LCT	5.64e-03	35	60	2	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	GBA3 LCT	6.62e-03	38	60	2	IPR013781
Domain	DEAH_ATP_HELICASE	YTHDC2 DHX34	6.62e-03	38	60	2	PS00690
Pathway	REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_IKBKE	PTPN11 IKBKE TBK1	2.24e-05	18	44	3	M970
Pathway	REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_IKBKE	PTPN11 IKBKE TBK1	2.65e-05	19	44	3	MM15644
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	IKBKE TBK1 RBCK1	4.81e-05	23	44	3	MM15177
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	IKBKE TBK1 RBCK1	6.22e-05	25	44	3	M27435
Pathway	KEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION	POLE2 TOPBP1 MTBP	7.88e-05	27	44	3	M47858
Pathway	KEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY	CASR PLCB4	1.98e-04	7	44	2	M47505
Pathway	KEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY	IKBKE TBK1	3.38e-04	9	44	2	M47598
Pathway	WP_SARSCOV2_B117_VARIANT_ANTAGONISES_INNATE_IMMUNE_ACTIVATION	IKBKE TBK1	3.38e-04	9	44	2	M42581
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	IKBKE TBK1	3.38e-04	9	44	2	M47451
Pathway	REACTOME_REGULATION_OF_TNFR1_SIGNALING	IKBKE TBK1 RBCK1	4.18e-04	47	44	3	MM15179
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	SPTBN2 PLCB4	4.22e-04	10	44	2	M47661
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION	IKBKE TBK1	5.14e-04	11	44	2	M48241
Pathway	REACTOME_TNF_SIGNALING	IKBKE TBK1 RBCK1	7.01e-04	56	44	3	MM15453
Pathway	REACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7	IKBKE TBK1	7.27e-04	13	44	2	M27884
Pathway	REACTOME_TNF_SIGNALING	IKBKE TBK1 RBCK1	7.38e-04	57	44	3	M27713
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	IKBKE TBK1	8.46e-04	14	44	2	M48239
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	IKBKE TBK1	8.46e-04	14	44	2	MM15642
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	IKBKE TBK1	9.74e-04	15	44	2	MM17228
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	IKBKE TBK1	9.74e-04	15	44	2	M953
Pubmed	A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.	MALT1 IKBKE RBCK1	1.12e-06	12	61	3	35099607
Pubmed	Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.	IKBKE TBK1	3.03e-06	2	61	2	27123832
Pubmed	IKKε and TBK1 expression in gastric cancer.	IKBKE TBK1	3.03e-06	2	61	2	27145266
Pubmed	Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.	IKBKE TBK1	3.03e-06	2	61	2	30349097
Pubmed	Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.	IKBKE TBK1	3.03e-06	2	61	2	15367631
Pubmed	IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.	IKBKE TBK1	3.03e-06	2	61	2	32858764
Pubmed	Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.	IKBKE TBK1	3.03e-06	2	61	2	30082428
Pubmed	Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.	IKBKE TBK1	3.03e-06	2	61	2	16888014
Pubmed	Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.	IKBKE TBK1	3.03e-06	2	61	2	36936901
Pubmed	Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.	IKBKE TBK1	3.03e-06	2	61	2	23096996
Pubmed	The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.	IKBKE TBK1	3.03e-06	2	61	2	15210742
Pubmed	Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells.	CASR GNA12	3.03e-06	2	61	2	19716891
Pubmed	Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.	GBA3 LCT	3.03e-06	2	61	2	12594539
Pubmed	The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling.	MALT1 RBCK1	3.03e-06	2	61	2	27006117
Pubmed	Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.	IKBKE TBK1	3.03e-06	2	61	2	17056502
Pubmed	Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.	IKBKE TBK1	3.03e-06	2	61	2	22619329
Pubmed	Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice.	MALT1 RBCK1	3.03e-06	2	61	2	36479846
Pubmed	The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.	IKBKE TBK1	3.03e-06	2	61	2	30504235
Pubmed	Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production.	IKBKE TBK1	3.03e-06	2	61	2	24722368
Pubmed	Clustering-induced signaling of CEACAM1 in PC12 cells.	PTPN11 CEACAM1	3.03e-06	2	61	2	12108545
Pubmed	Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?	IKBKE TBK1	3.03e-06	2	61	2	18353649
Pubmed	The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.	IKBKE TBK1	3.03e-06	2	61	2	23157677
Pubmed	Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population.	CASR LCT	3.03e-06	2	61	2	18980667
Pubmed	Crystal structure and mechanism of activation of TANK-binding kinase 1.	IKBKE TBK1	3.03e-06	2	61	2	23453971
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ATG4B PDCD6IP PPP2R2D SMCHD1 TOPBP1 KDM3B DEPDC5 DHX34	3.94e-06	529	61	8	14621295
Pubmed	ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.	ATG4B TBK1	9.07e-06	3	61	2	37434364
Pubmed	Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.	IKBKE TBK1	9.07e-06	3	61	2	29755980
Pubmed	ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.	IKBKE TBK1	9.07e-06	3	61	2	22787218
Pubmed	ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling.	DRD1 PDCD6IP	9.07e-06	3	61	2	18380665
Pubmed	Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform.	IKBKE TBK1	9.07e-06	3	61	2	24706939
Pubmed	HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.	IKBKE TBK1	9.07e-06	3	61	2	25531185
Pubmed	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.	IKBKE TBK1	9.07e-06	3	61	2	17327220
Pubmed	The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.	MALT1 RBCK1	9.07e-06	3	61	2	26525107
Pubmed	TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.	IKBKE TBK1	9.07e-06	3	61	2	34518217
Pubmed	Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.	TOPBP1 MTBP	9.07e-06	3	61	2	23704573
Pubmed	SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.	IKBKE TBK1	9.07e-06	3	61	2	25939384
Pubmed	Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.	IKBKE TBK1	9.07e-06	3	61	2	16380379
Pubmed	Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.	IKBKE TBK1	9.07e-06	3	61	2	31662325
Pubmed	Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies.	IKBKE TBK1	9.07e-06	3	61	2	24335286
Pubmed	Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.	IKBKE TBK1	9.07e-06	3	61	2	34260286
Pubmed	IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.	IKBKE TBK1	9.07e-06	3	61	2	11839743
Pubmed	The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.	IKBKE TBK1	9.07e-06	3	61	2	32220666
Pubmed	A20 is a negative regulator of IFN regulatory factor 3 signaling.	IKBKE TBK1	9.07e-06	3	61	2	15661910
Pubmed	Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.	IKBKE TBK1	9.07e-06	3	61	2	24368730
Pubmed	Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS.	IKBKE TBK1	1.81e-05	4	61	2	37967220
Pubmed	Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.	IKBKE TBK1	1.81e-05	4	61	2	35289316
Pubmed	TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.	IKBKE TBK1	1.81e-05	4	61	2	32268090
Pubmed	SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.	IKBKE TBK1	1.81e-05	4	61	2	16281057
Pubmed	Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.	IKBKE TBK1	1.81e-05	4	61	2	24509444
Pubmed	TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.	IKBKE TBK1	1.81e-05	4	61	2	24562310
Pubmed	Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.	IKBKE TBK1	1.81e-05	4	61	2	19153231
Pubmed	IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.	IKBKE TBK1	1.81e-05	4	61	2	38167258
Pubmed	Estrogen receptor alpha inhibits RLR-mediated immune response via ubiquitinating TRAF3.	IKBKE TBK1	1.81e-05	4	61	2	26186972
Pubmed	TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.	IKBKE TBK1	1.81e-05	4	61	2	28011935
Pubmed	A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.	IKBKE TBK1	1.81e-05	4	61	2	15556946
Pubmed	The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination.	IKBKE TBK1	1.81e-05	4	61	2	31534043
Pubmed	Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.	IKBKE TBK1	1.81e-05	4	61	2	18467330
Pubmed	Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.	IKBKE TBK1	1.81e-05	4	61	2	27705791
Pubmed	Functional dissection of the TBK1 molecular network.	IKBKE TBK1	1.81e-05	4	61	2	21931631
Pubmed	TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.	IKBKE TBK1 RBCK1	2.02e-05	30	61	3	30420664
Pubmed	SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.	IKBKE TBK1 RBCK1	2.23e-05	31	61	3	27307491
Pubmed	TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.	IKBKE TBK1	3.02e-05	5	61	2	22851696
Pubmed	IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.	IKBKE TBK1	3.02e-05	5	61	2	22072751
Pubmed	The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.	IKBKE TBK1	3.02e-05	5	61	2	16393995
Pubmed	IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.	IKBKE TBK1	3.02e-05	5	61	2	21464307
Pubmed	Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.	IKBKE TBK1	3.02e-05	5	61	2	34257412
Pubmed	RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.	IKBKE TBK1	3.02e-05	5	61	2	23308279
Pubmed	A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.	IKBKE TBK1	3.02e-05	5	61	2	23396947
Pubmed	Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.	PTPN11 TBK1	3.02e-05	5	61	2	26358190
Pubmed	Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.	IKBKE TBK1	3.02e-05	5	61	2	17015689
Pubmed	The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.	IKBKE TBK1	3.02e-05	5	61	2	17468758
Pubmed	Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.	IKBKE TBK1	3.02e-05	5	61	2	22007846
Pubmed	The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.	IKBKE TBK1	3.02e-05	5	61	2	37130168
Pubmed	NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.	IKBKE TBK1	3.02e-05	5	61	2	20389019
Pubmed	A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages.	IKBKE TBK1	3.02e-05	5	61	2	25780039
Pubmed	Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.	IKBKE TBK1	3.02e-05	5	61	2	16914100
Pubmed	Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.	IKBKE TBK1	3.02e-05	5	61	2	25606824
Pubmed	ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.	IKBKE TBK1	4.52e-05	6	61	2	21885437
Pubmed	SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.	IKBKE TBK1	4.52e-05	6	61	2	24622840
Pubmed	The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.	IKBKE TBK1	4.52e-05	6	61	2	15695821
Pubmed	NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.	IKBKE TBK1	4.52e-05	6	61	2	17142768
Pubmed	UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS.	IKBKE TBK1	4.52e-05	6	61	2	36943869
Pubmed	Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.	IKBKE TBK1	4.52e-05	6	61	2	14560022
Pubmed	Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus.	IKBKE TBK1	4.52e-05	6	61	2	32511263
Pubmed	SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.	IKBKE TBK1	4.52e-05	6	61	2	34084167
Pubmed	FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.	IKBKE TBK1	4.52e-05	6	61	2	33822771
Pubmed	Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.	IKBKE TBK1	4.52e-05	6	61	2	34239064
Pubmed	MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex.	IKBKE TBK1	6.32e-05	7	61	2	29920243
Pubmed	IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.	IKBKE TBK1	6.32e-05	7	61	2	29563620
Pubmed	Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.	IKBKE TBK1	6.32e-05	7	61	2	29251827
Pubmed	A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.	IKBKE TBK1	6.32e-05	7	61	2	23950712
Pubmed	The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.	IKBKE TBK1	6.32e-05	7	61	2	18636086
Pubmed	TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.	IKBKE TBK1	6.32e-05	7	61	2	37023504
Pubmed	LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages.	PTPN11 TBK1	6.32e-05	7	61	2	17954568
Pubmed	Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.	IKBKE TBK1	6.32e-05	7	61	2	22252317
Pubmed	MIP-T3 is a negative regulator of innate type I IFN response.	IKBKE TBK1	6.32e-05	7	61	2	22079989
Pubmed	Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.	IKBKE TBK1	6.32e-05	7	61	2	19380580
Pubmed	The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene.	IKBKE TBK1	6.32e-05	7	61	2	27129230
Pubmed	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.	IKBKE TBK1	6.32e-05	7	61	2	12692549
Pubmed	E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.	IKBKE TBK1	6.32e-05	7	61	2	32298923
GeneFamily	Dyneins, axonemal	DNAH2 DNAH9	4.06e-04	17	32	2	536
ToppCell	severe_COVID-19-B_cell\|severe_COVID-19 / disease group, cell group and cell class (v2)	ZNF430 PRDM11 HAUS3 GNA12 CEACAM1	1.61e-06	144	61	5	c7f696e55e2d959c58ec32640c71ef86ee25203c
Disease	end stage renal disease (is_marker_for)	CASR MMP10 BDKRB1	1.20e-04	46	61	3	DOID:783 (is_marker_for)
Disease	blood phosphate measurement	PTPN11 SPTBN2 CASR ECE1	4.69e-04	174	61	4	EFO_0010972
Disease	facial asymmetry measurement	POLE2 EMP2	7.03e-04	19	61	2	EFO_0009751
Disease	Early Pregnancy Loss	CD69 FETUB CEACAM1	1.51e-03	109	61	3	C3830362
Disease	Miscarriage	CD69 FETUB CEACAM1	1.51e-03	109	61	3	C4552766
Disease	Spontaneous abortion	CD69 FETUB CEACAM1	1.51e-03	109	61	3	C0000786
Disease	Abortion, Tubal	CD69 FETUB CEACAM1	1.51e-03	109	61	3	C0000822
Disease	hypertension (is_implicated_in)	DRD1 ECE1 BDKRB1	2.04e-03	121	61	3	DOID:10763 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FQVQAVRGCFWEDFI	BDKRB1	276	P46663
FEDKVANIWCSFNVF	ALG6	271	Q9Y672
GFAKEFWEETFNCHL	CASR	346	P41180
FQWCFSQVKGAIDED	PPP2R2D	16	Q66LE6
DTLDFWFACNGFRQM	AXIN2	106	Q9Y2T1
KQENCSWTSFRDFFF	DDIT4L	141	Q96D03
ACFVLAEGWFEDQVF	POLE2	221	P56282
FCIDSNTFDVFVWFG	DRD1	306	P21728
FFCKTEDDFNDWCQQ	ATG4B	321	Q9Y4P1
ATFSEFQEKGFRIQW	R3HCC1	336	Q9Y3T6
DVFQVAKAEFRAFWC	MPEG1	451	Q2M385
FNNWFNVTGSDKCVF	CD69	161	Q07108
NSRDTVFIFKGNEFW	MMP10	346	P09238
AGVDDFASFQRKWFE	DEPDC5	1281	O75140
FTFEFSQWSQLDVCD	MALT1	196	Q9UDY8
CKGWCFFEDDVNEFT	RBCK1	376	Q9BYM8
CIFNFAFWGDTAVER	FPR3	176	P25089
EVEQAKCWGFDQFFA	IKBKE	286	Q14164
WEKFVSVTCDFFESQ	FETUB	246	Q9UGM5
ENQICLTFTWKDAFD	PDCD6IP	86	Q8WUM4
FEWNEGLCKVFVSTF	GPR153	76	Q6NV75
QDLAIFVEFDGCNWK	KDM3B	61	Q7LBC6
ADFCFQTFGDRVKFW	LCT	1046	P09848
NSESFAAWCRFGKRE	LRATD1	211	Q96KN4
GVQVVFWCLNEESDF	GDPD3	271	Q7L5L3
GFWEEFETLQQQECK	PTPN11	246	Q06124
VECSDVKFFQLAAQW	PACS2	856	Q86VP3
ADQDFSFKAGQWVDF	OXNAD1	86	Q96HP4
CRRQFQEGEEWNCFF	NOTUM	306	Q6P988
ERRVFAECNDESFWF	OCIAD1	31	Q9NX40
GDEFFADVWRICTNN	EMP2	31	P54851
SCRNEEGKAVDWFTF	DNASE2B	31	Q8WZ79
AQFCFSTFGDRVKQW	GBA3	146	Q9H227
VKREDAGTYWCEVFN	CEACAM1	386	P13688
WDEGKRNSGFRQCFF	FNDC3B	416	Q53EP0
VDFDQRDNGFCSWLT	TMEM63B	116	Q5T3F8
QKWFQCFDGITSILF	GNA12	236	Q03113
DESFLKWFCGNVNEQ	HAUS3	36	Q68CZ6
GAWGCFDEFNRISVE	DNAH9	1916	Q9NYC9
RWKFCVSDTENNLGF	ECE1	431	P42892
RQGSEECQKFWTFFE	DHX34	51	Q14147
AQTGAWGCFDEFNRI	DNAH2	1846	Q9P225
WERKFGFEISFPEFC	MTBP	246	Q96DY7
RGNQFWEKLCTAEFR	KBTBD12	361	Q3ZCT8
NKDLCFTWREFSDFI	SMCHD1	1231	A6NHR9
NCLFKVDEFGFFLTW	PLCB4	36	Q15147
CFCFQRAFKSFDDVW	TBC1D21	241	Q8IYX1
SFQQVDFWFCESCQE	PRDM11	101	Q9NQV5
FWTEFNCFQECLKQS	IARS1	21	P41252
DCTNVTFSKVQRFWE	RRP12	101	Q5JTH9
RSQNRGGSEFKFWFC	LINC00173	111	Q6ZV60
FECQWRDDTGNYKGV	ZNF160	141	Q9HCG1
EAFQKSAVAWEERFC	SPTBN2	2056	O15020
FREDCAFSSPFWKDE	STON1	176	Q9Y6Q2
GNLWENTRFTDCSFF	SPOPL	191	Q6IQ16
RWFFNFETGECELFA	SPINT3	51	P49223
EECGKVFNWFSTLTR	ZNF430	236	Q9H8G1
RSDGWERAFCEKNFL	YTHDC2	911	Q9H6S0
KSLEFWREYQFCDGA	ZMYM1	521	Q5SVZ6
WFFDSIEKGFCQDES	TOPBP1	266	Q92547
EADQEKCWGFDQFFA	TBK1	286	Q9UHD2