Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	U2-type precatalytic spliceosome	PRPF3 RBMX2 SRRM2	3.65e-04	51	57	3	GO:0071005
GeneOntologyCellularComponent	precatalytic spliceosome	PRPF3 RBMX2 SRRM2	4.32e-04	54	57	3	GO:0071011
Domain	cwf21	U2SURP SRRM2	8.51e-06	2	55	2	PF08312
Domain	mRNA_splic_Cwf21_dom	U2SURP SRRM2	8.51e-06	2	55	2	IPR013170
Domain	RPR	SCAF8 U2SURP	2.36e-04	8	55	2	SM00582
Domain	CID	SCAF8 U2SURP	2.36e-04	8	55	2	PS51391
Domain	CID_dom	SCAF8 U2SURP	2.36e-04	8	55	2	IPR006569
Domain	RRM_1	SAFB SRSF5 SCAF8 RBMX2 U2SURP	3.61e-04	208	55	5	PF00076
Domain	RRM	SAFB SRSF5 SCAF8 RBMX2 U2SURP	4.39e-04	217	55	5	SM00360
Domain	RRM_dom	SAFB SRSF5 SCAF8 RBMX2 U2SURP	5.38e-04	227	55	5	IPR000504
Domain	RRM	SAFB SRSF5 SCAF8 RBMX2 U2SURP	5.71e-04	230	55	5	PS50102
Domain	-	SAFB SRSF5 SCAF8 RBMX2 U2SURP	7.46e-04	244	55	5	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SAFB SRSF5 SCAF8 RBMX2 U2SURP	9.58e-04	258	55	5	IPR012677
Domain	ENTH_VHS	SCAF8 U2SURP	3.29e-03	29	55	2	IPR008942
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	SRSF5 PRPF3 RBMX2 U2SURP FIP1L1 SRRM2	8.87e-05	277	38	6	MM15414
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	SRSF5 PRPF3 RBMX2 U2SURP FIP1L1 SRRM2	9.98e-05	283	38	6	M13087
Pathway	REACTOME_MRNA_SPLICING	SRSF5 PRPF3 RBMX2 U2SURP SRRM2	1.92e-04	201	38	5	MM15411
Pathway	REACTOME_MRNA_SPLICING	SRSF5 PRPF3 RBMX2 U2SURP SRRM2	2.46e-04	212	38	5	M14033
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1E RYR2	3.83e-04	11	38	2	M47958
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	SAFB SRSF5 RSF1 FIP1L1 NKTR SRRM2 THRAP3	2.87e-08	188	58	7	29721183
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	SAFB SRSF5 RBMX2 KIF21A ZFP91 RSF1 NKTR THRAP3	7.66e-08	330	58	8	33301849
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SAFB PRPF3 U2SURP FIP1L1 SRRM2 THRAP3	8.38e-08	130	58	6	35545047
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SECISBP2L KIAA1671 CDKL5 SRSF5 FIP1L1 SPECC1L SRRM2 THRAP3	1.52e-07	361	58	8	30344098
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SYCP2 SAFB SRSF5 ZFP91 FIP1L1 SRRM2 ATP10A THRAP3	1.52e-07	361	58	8	26167880
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SAFB PRPF3 CLK2 RBMX2 RSF1 FIP1L1 THRAP3	2.06e-07	251	58	7	31076518
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK5 SRSF5 PRPF3 SCAF8 KIF21A U2SURP FIP1L1 SRRM2 THRAP3	4.97e-07	582	58	9	20467437
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCAPD3 SAFB SRSF5 SCAF8 RBMX2 ZFP91 FIP1L1 TOPORS SRRM2 THRAP3	5.60e-07	774	58	10	15302935
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	KIAA1671 DOCK5 CDKL5 CCDC88A CDC42EP4 FIP1L1 ABCC5 SPECC1L THRAP3 RYR2	5.80e-07	777	58	10	35844135
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	NCAPD3 SAFB SRSF5 PRPF3 U2SURP ZFP91 FIP1L1 SPECC1L SRRM2 THRAP3	1.26e-06	847	58	10	35850772
Pubmed	Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing.	CFAP47 CCDC187	2.73e-06	2	58	2	25751143
Pubmed	Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.	CDKL5 CACNA1E	2.73e-06	2	58	2	38081835
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	SRSF5 RBMX2 FIP1L1 NKTR SRRM2 THRAP3	4.71e-06	259	58	6	30404004
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	SAFB PRPF3 RBMX2 FIP1L1 THRAP3	4.98e-06	148	58	5	32538781
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SAFB RSF1 FIP1L1 SRRM2 THRAP3	7.97e-06	163	58	5	22113938
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DOCK5 NCAPD3 SAFB SRSF5 PRPF3 RBMX2 U2SURP FIP1L1 NKTR SRRM2 THRAP3	8.28e-06	1294	58	11	30804502
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SAFB SRSF5 PRPF3 U2SURP ZFP91 RSF1 FIP1L1 SRRM2	1.24e-05	653	58	8	33742100
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KIAA1671 SAFB SRSF5 PRPF3 U2SURP SPECC1L SRRM2 THRAP3	1.34e-05	660	58	8	32780723
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	NCAPD3 SAFB CCDC88A SRSF5 U2SURP FIP1L1 SRRM2 THRAP3	1.49e-05	670	58	8	22990118
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	NCAPD3 SRSF5 PRPF3 RBMX2 U2SURP SRRM2 THRAP3	1.62e-05	486	58	7	30940648
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CDKL5 ABL1 CDC42EP4 SRSF5 CLK2 FIP1L1 SRRM2 THRAP3	1.94e-05	695	58	8	23602568
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	SRSF5 PRPF3 RBMX2 U2SURP SRRM2	1.99e-05	197	58	5	22365833
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SAFB SRSF5 PRPF3 U2SURP FIP1L1 NKTR SRRM2 THRAP3	2.33e-05	713	58	8	29802200
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	SAFB SRSF5 PRPF3 SCAF8 RBMX2 U2SURP	2.47e-05	347	58	6	16033648
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	SAFB PRPF3 RBMX2 U2SURP ZFP91 FIP1L1 SPECC1L SRRM2 THRAP3	2.59e-05	949	58	9	36574265
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	SAFB SRSF5 PRPF3 RBMX2 U2SURP FIP1L1 SRRM2 THRAP3	2.78e-05	731	58	8	29298432
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	U2SURP SPECC1L SRRM2 WNK1	2.83e-05	104	58	4	9205841
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	PRPF3 SCAF8 U2SURP FIP1L1 THRAP3	3.38e-05	220	58	5	24550385
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	NCAPD3 CCDC88A U2SURP FIP1L1 SRRM2	3.52e-05	222	58	5	35941108
Pubmed	Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.	ABL1 FIP1L1	4.08e-05	6	58	2	22447844
Pubmed	A coactivator of pre-mRNA splicing.	SRSF5 SRRM2	4.08e-05	6	58	2	9531537
Pubmed	Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.	SAFB CLK2	4.08e-05	6	58	2	19282290
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	SRSF5 PRPF3 U2SURP SRRM2	4.19e-05	115	58	4	17332742
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SECISBP2L SAFB SRSF5 PRPF3 U2SURP FIP1L1 SRRM2 THRAP3	5.58e-05	807	58	8	22681889
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	SAFB PRPF3 RBMX2 ZFP91 FIP1L1	5.96e-05	248	58	5	27926873
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	SAFB SRSF5 PRPF3 U2SURP FIP1L1 SRRM2 THRAP3	6.49e-05	605	58	7	28977666
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	CLK2 SRRM2 WNK1 THRAP3 FARP2	6.80e-05	255	58	5	15324660
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SAFB SRSF5 PRPF3 RBMX2 U2SURP ZNF324 FIP1L1 SRRM2 THRAP3	7.15e-05	1082	58	9	38697112
Pubmed	SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.	SAFB CLK2	7.60e-05	8	58	2	9671816
Pubmed	KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.	SAFB SRSF5 RSF1	8.16e-05	50	58	3	32068487
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 USP31 CCDC88A ABL1 CDC42EP4 FIP1L1 SRRM2 WNK1	8.76e-05	861	58	8	36931259
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SAFB PRPF3 FIP1L1 SPECC1L THRAP3	9.53e-05	274	58	5	34244482
Pubmed	The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.	SPECC1L WNK1	9.77e-05	9	58	2	17289029
Pubmed	Regulation of alternative splicing by SRrp86 and its interacting proteins.	SAFB SRSF5 THRAP3	1.21e-04	57	58	3	14559993
Pubmed	Comparative mapping in the beige-satin region of mouse chromosome 13.	BMP6 RYR2	1.22e-04	10	58	2	9027500
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	PRPF3 FIP1L1 SRRM2 THRAP3	1.30e-04	154	58	4	16055720
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	ABL1 CLK2 RSF1 THRAP3	1.40e-04	157	58	4	30686591
Pubmed	Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.	FIP1L1 NKTR	1.49e-04	11	58	2	14729963
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	SAFB SRSF5 CLK2 RBMX2 FIP1L1 NKTR SPECC1L	1.62e-04	701	58	7	30196744
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	U2SURP BTBD10 FIP1L1 THRAP3 FARP2	1.77e-04	313	58	5	38270169
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	SAFB RSF1 FIP1L1 SRRM2 WNK1 THRAP3	1.90e-04	503	58	6	16964243
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	SAFB PRPF3 FIP1L1 SRRM2	1.90e-04	170	58	4	16159877
Pubmed	Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense.	CCDC88A ZFP91	2.46e-04	14	58	2	35320721
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	PRPF3 U2SURP SRRM2 THRAP3	2.47e-04	182	58	4	26527279
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NCAPD3 SRSF5 FIP1L1 SRRM2 THRAP3	2.63e-04	341	58	5	32971831
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	KIAA1671 SAFB PRPF3 U2SURP FIP1L1 SPECC1L SRRM2 THRAP3	2.86e-04	1024	58	8	24711643
Pubmed	Luzp4 defines a new mRNA export pathway in cancer cells.	KIAA1671 SPECC1L THRAP3	3.30e-04	80	58	3	25662211
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SECISBP2L GZF1 SRSF5 RBMX2 ZFP91 FIP1L1 NKTR SPECC1L THRAP3	4.18e-04	1371	58	9	36244648
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	NCAPD3 PRPF3 SRRM2 THRAP3	4.25e-04	210	58	4	16565220
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	GZF1 ZFP91	4.59e-04	19	58	2	30385546
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	NCAPD3 SAFB PRPF3 U2SURP ZFP91 FIP1L1 SRRM2 THRAP3	4.69e-04	1103	58	8	34189442
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KIAA1671 PRPF3 ZFP91 RSF1 ZNF324 FIP1L1 TOPORS SRRM2	5.06e-04	1116	58	8	31753913
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	SAFB SRSF5 U2SURP FIP1L1 SRRM2 THRAP3	5.54e-04	615	58	6	31048545
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1E SAFB RBMX2 KIF21A U2SURP RSF1 ABCC5 THRAP3 RYR2	6.02e-04	1442	58	9	35575683
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	SAFB RSF1 TOPORS SRRM2 THRAP3	6.16e-04	411	58	5	35182466
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CACNA1E TPH2 ABCC5 SRRM2	6.27e-04	233	58	4	37704626
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	CCDC88A GZF1 SRSF5 PRPF3 FARP2	6.58e-04	417	58	5	36537216
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF490 USP31 CCDC88A	6.91e-04	103	58	3	10574462
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	SRSF5 ZFP91 RSF1 FIP1L1 WNK1 THRAP3	7.10e-04	645	58	6	25281560
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SECISBP2L DOCK5 NCAPD3 CCDC88A SCAF8 FARP2	7.39e-04	650	58	6	38777146
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	SAFB SRSF5 U2SURP THRAP3	7.45e-04	244	58	4	29884807
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	SRSF5 U2SURP SRRM2 THRAP3	7.56e-04	245	58	4	21182205
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	KIAA1671 DOCK5 SRSF5 PRPF3 FIP1L1 NKTR FARP2	8.03e-04	916	58	7	32203420
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	PRPF3 U2SURP	8.66e-04	26	58	2	33298525
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SAFB SRSF5 FIP1L1	9.28e-04	114	58	3	31553912
Pubmed	Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.	KIF21A WNK1	1.00e-03	28	58	2	38324473
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SAFB PRPF3 U2SURP RSF1 FIP1L1 SRRM2 THRAP3	1.02e-03	954	58	7	36373674
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SRSF5 KIF21A U2SURP FIP1L1 SPECC1L TOPORS SRRM2 THRAP3	1.04e-03	1247	58	8	27684187
Pubmed	A genetic linkage map of the mouse: current applications and future prospects.	BMP6 NKTR	1.15e-03	30	58	2	8211130
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CACNA1E SAFB SCAF8 BTBD10 CCDC177	1.18e-03	475	58	5	31040226
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	U2SURP NKTR SPECC1L SRRM2 THRAP3	1.20e-03	477	58	5	31300519
Pubmed	A human MAP kinase interactome.	CCDC88A CDC42EP4 NKTR SPECC1L WNK1	1.30e-03	486	58	5	20936779
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	SAFB U2SURP SPECC1L THRAP3	1.34e-03	286	58	4	32041737
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	PRPF3 U2SURP FIP1L1	1.48e-03	134	58	3	25452129
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SAFB CLK2 SCAF8 RBMX2 U2SURP NKTR SRRM2 THRAP3	1.48e-03	1318	58	8	30463901
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SECISBP2L KIAA1671 DOCK5 CCDC88A SRSF5 PRPF3 NKTR WNK1	1.50e-03	1321	58	8	27173435
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	LNX2 ZFP91 FIP1L1 SPECC1L THRAP3	1.51e-03	503	58	5	36217030
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	PRPF3 FIP1L1 SRRM2	1.57e-03	137	58	3	37039823
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	PRPF3 SCAF8 U2SURP SRRM2	1.60e-03	300	58	4	28561026
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SECISBP2L CCDC88A SRSF5 FIP1L1 WNK1 THRAP3 FARP2	1.65e-03	1038	58	7	26673895
Interaction	SRPK2 interactions	SYCP2 SAFB ABL1 CDC42EP4 SRSF5 CLK2 RBMX2 U2SURP ZFP91 FIP1L1 NKTR SRRM2 THRAP3	6.05e-08	717	56	13	int:SRPK2
Interaction	SRSF4 interactions	GZF1 SRSF5 CLK2 KIF21A U2SURP NKTR TOPORS SRRM2 THRAP3	1.31e-07	300	56	9	int:SRSF4
Interaction	RNPS1 interactions	ZNF490 PRPF3 CLK2 ZFP91 FIP1L1 NKTR TOPORS SRRM2 THRAP3 FARP2	2.34e-07	425	56	10	int:RNPS1
Interaction	DHX8 interactions	SAFB PRPF3 RBMX2 U2SURP FIP1L1 NKTR SRRM2 THRAP3	1.37e-06	292	56	8	int:DHX8
Interaction	SNIP1 interactions	SRSF5 PRPF3 CLK2 RBMX2 FIP1L1 NKTR TOPORS SRRM2 THRAP3	2.04e-06	417	56	9	int:SNIP1
Interaction	SRSF8 interactions	CCDC88A SRSF5 CLK2 RBMX2 THRAP3	7.70e-06	98	56	5	int:SRSF8
Interaction	SRSF6 interactions	GZF1 SRSF5 CLK2 KIF21A U2SURP NKTR TOPORS SRRM2 THRAP3	9.34e-06	503	56	9	int:SRSF6
Interaction	SRPK3 interactions	GZF1 SRSF5 CLK2 U2SURP SRRM2 THRAP3	1.42e-05	190	56	6	int:SRPK3
Interaction	SAP18 interactions	SAFB SRSF5 CLK2 NKTR TOPORS SRRM2 THRAP3	2.09e-05	305	56	7	int:SAP18
Interaction	SRSF7 interactions	SAFB SRSF5 PRPF3 CLK2 U2SURP NKTR SRRM2 THRAP3	2.14e-05	425	56	8	int:SRSF7
Interaction	SON interactions	SAFB SRSF5 PRPF3 CLK2 NKTR SRRM2	2.38e-05	208	56	6	int:SON
Interaction	ZC3H18 interactions	SAFB SRSF5 PRPF3 CLK2 RBMX2 U2SURP FIP1L1 NKTR TOPORS SRRM2 THRAP3	2.46e-05	877	56	11	int:ZC3H18
Interaction	YWHAG interactions	KIAA1671 USP31 LNX2 CCDC88A ABL1 CLK2 FIP1L1 NKTR SPECC1L SRRM2 WNK1 THRAP3 FARP2	2.87e-05	1248	56	13	int:YWHAG
Interaction	PPP1CC interactions	SECISBP2L KIAA1671 CDKL5 SRSF5 BTBD10 FIP1L1 SPECC1L SRRM2 THRAP3 RYR2	3.16e-05	738	56	10	int:PPP1CC
Interaction	CLK1 interactions	SAFB SRSF5 CLK2 SRRM2 ATP10A THRAP3	3.17e-05	219	56	6	int:CLK1
Interaction	ZBTB2 interactions	SAFB SRSF5 RBMX2 KIF21A ZFP91 RSF1 NKTR THRAP3	3.22e-05	450	56	8	int:ZBTB2
Interaction	NKAP interactions	PRPF3 RBMX2 NKTR TOPORS SRRM2	3.26e-05	132	56	5	int:NKAP
Interaction	PURG interactions	GZF1 SRSF5 CLK2 RBMX2 U2SURP NKTR	3.51e-05	223	56	6	int:PURG
Interaction	RAD18 interactions	SAFB PRPF3 CLK2 RBMX2 RSF1 FIP1L1 SRRM2 THRAP3	3.60e-05	457	56	8	int:RAD18
Interaction	DDX23 interactions	SAFB PRPF3 RBMX2 U2SURP FIP1L1 NKTR SRRM2 THRAP3	5.09e-05	480	56	8	int:DDX23
Interaction	NUP43 interactions	SAFB CCDC88A ARGFX RBMX2 ZFP91 RSF1 NKTR SRRM2 RYR2	5.16e-05	625	56	9	int:NUP43
Interaction	HMGB1 interactions	SAFB SRSF5 KIF21A RSF1 FIP1L1 NKTR SRRM2 THRAP3	5.55e-05	486	56	8	int:HMGB1
Interaction	RPS19 interactions	GZF1 SRSF5 KIF21A U2SURP ZFP91 FIP1L1 SRRM2 THRAP3 FARP2	6.12e-05	639	56	9	int:RPS19
Interaction	ZRSR2 interactions	SRSF5 CLK2 U2SURP NKTR	6.22e-05	77	56	4	int:ZRSR2
Interaction	NKAPD1 interactions	PRPF3 CLK2 NKTR SRRM2 THRAP3	8.41e-05	161	56	5	int:NKAPD1
Interaction	LUZP4 interactions	KIAA1671 CLK2 SPECC1L THRAP3	1.65e-04	99	56	4	int:LUZP4
Interaction	PNN interactions	CLK2 RBMX2 NKTR TOPORS SRRM2 THRAP3	1.86e-04	302	56	6	int:PNN
Interaction	CLK2 interactions	CLK2 FIP1L1 NKTR SRRM2 THRAP3	2.06e-04	195	56	5	int:CLK2
Interaction	GSPT2 interactions	CLK2 U2SURP SRRM2 THRAP3	2.23e-04	107	56	4	int:GSPT2
Interaction	GPALPP1 interactions	CDKL5 CLK2 THRAP3	2.48e-04	44	56	3	int:GPALPP1
Interaction	GSK3A interactions	KIAA1671 CCDC88A KIF21A U2SURP TOPORS SRRM2 THRAP3	2.87e-04	464	56	7	int:GSK3A
Interaction	PRP4K interactions	SRSF5 PRPF3 CLK2 FIP1L1 SRRM2 THRAP3	2.95e-04	329	56	6	int:PRP4K
Interaction	TRA2A interactions	SRSF5 PRPF3 CLK2 U2SURP SRRM2 THRAP3	3.00e-04	330	56	6	int:TRA2A
Interaction	PRPF6 interactions	SRSF5 PRPF3 CLK2 U2SURP SRRM2 THRAP3	3.31e-04	336	56	6	int:PRPF6
Interaction	DOT1L interactions	NCAPD3 SAFB SRSF5 PRPF3 U2SURP FIP1L1 SPECC1L SRRM2 THRAP3	3.54e-04	807	56	9	int:DOT1L
Interaction	CLK3 interactions	SRSF5 CLK2 TOPORS SRRM2 THRAP3	3.60e-04	220	56	5	int:CLK3
Interaction	SNRPA interactions	SAFB PRPF3 CLK2 FIP1L1 NKTR SRRM2 THRAP3	3.61e-04	482	56	7	int:SNRPA
Interaction	RNF151 interactions	PRPF3 CLK2 NKTR SRRM2	3.80e-04	123	56	4	int:RNF151
Interaction	EP300 interactions	NUTM1 SAFB ABL1 ARGFX SRSF5 PRPF3 U2SURP ZFP91 RSF1 FIP1L1 SRRM2 THRAP3	3.87e-04	1401	56	12	int:EP300
Interaction	U2AF2 interactions	SAFB SRSF5 PRPF3 CLK2 U2SURP NKTR SRRM2 THRAP3	4.10e-04	651	56	8	int:U2AF2
Interaction	SEPTIN7 interactions	SAFB CDC42EP4 SRSF5 PRPF3 SRRM2	4.24e-04	228	56	5	int:SEPTIN7
Interaction	CTNND2 interactions	CDKL5 LNX2 ABL1	4.56e-04	54	56	3	int:CTNND2
Interaction	CD2BP2 interactions	PRPF3 U2SURP NKTR SRRM2 THRAP3	4.59e-04	232	56	5	int:CD2BP2
Interaction	PAXIP1 interactions	NCAPD3 CCDC88A SRSF5 U2SURP SRRM2 THRAP3	4.70e-04	359	56	6	int:PAXIP1
Interaction	ZCCHC10 interactions	PRPF3 CLK2 NKTR TOPORS SRRM2	4.96e-04	236	56	5	int:ZCCHC10
Interaction	LLGL2 interactions	FIP1L1 NKTR TOPORS THRAP3	5.10e-04	133	56	4	int:LLGL2
Interaction	LUC7L interactions	CLK2 ZFP91 NKTR SRRM2 THRAP3	5.56e-04	242	56	5	int:LUC7L
Interaction	NUPR1 interactions	KIAA1671 SAFB SRSF5 PRPF3 U2SURP SPECC1L SRRM2 THRAP3	5.64e-04	683	56	8	int:NUPR1
Interaction	FOXA1 interactions	KIAA1671 SAFB PRPF3 RBMX2 ZFP91 FIP1L1 THRAP3	6.01e-04	525	56	7	int:FOXA1
Interaction	CPSF6 interactions	SAFB PRPF3 CLK2 FIP1L1 NKTR SRRM2 THRAP3	6.08e-04	526	56	7	int:CPSF6
Interaction	RAPGEF5 interactions	DOCK5 CCDC88A WNK1	6.22e-04	60	56	3	int:RAPGEF5
Interaction	SNRPF interactions	SRSF5 PRPF3 U2SURP NKTR SRRM2 THRAP3	6.78e-04	385	56	6	int:SNRPF
Interaction	MECP2 interactions	CDKL5 SAFB SRSF5 PRPF3 RBMX2 U2SURP ZNF324 FIP1L1 NKTR SRRM2 THRAP3	7.17e-04	1287	56	11	int:MECP2
Interaction	APOBEC3D interactions	SAFB CLK2 U2SURP THRAP3	7.63e-04	148	56	4	int:APOBEC3D
Interaction	DDX21 interactions	SAFB SRSF5 PRPF3 RBMX2 U2SURP ZFP91 SRRM2 THRAP3	7.82e-04	718	56	8	int:DDX21
Interaction	CEP70 interactions	ZNF490 ZNF555 PRPF3 ZFP91 CCDC187	7.95e-04	262	56	5	int:CEP70
Interaction	YWHAH interactions	KIAA1671 USP31 CCDC88A ABL1 CDC42EP4 CLK2 NKTR SPECC1L SRRM2 WNK1	8.20e-04	1102	56	10	int:YWHAH
Interaction	RPSA2 interactions	GZF1 SRSF5 U2SURP ZFP91	8.42e-04	152	56	4	int:RPSA2
Interaction	ZNF816 interactions	NKTR TOPORS	8.88e-04	16	56	2	int:ZNF816
Interaction	JPH4 interactions	CLK2 RBMX2 RYR2	8.96e-04	68	56	3	int:JPH4
Interaction	SF3A2 interactions	SRSF5 PRPF3 U2SURP SRRM2 THRAP3	9.56e-04	273	56	5	int:SF3A2
Interaction	SRSF1 interactions	SRSF5 CLK2 RBMX2 U2SURP ZFP91 SRRM2 THRAP3	9.74e-04	570	56	7	int:SRSF1
GeneFamily	RNA binding motif containing	SAFB SRSF5 SCAF8 RBMX2 U2SURP	5.27e-05	213	35	5	725
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 USP31 SYCP2 CCDC177 FARP2	1.80e-06	155	58	5	441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	SYCP2 CCDC88A RSF1 NKTR SRRM2	5.81e-06	197	58	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
Disease	Involutional paraphrenia	GALR1 TPH2	1.03e-03	25	56	2	C1571983
Disease	Psychosis, Involutional	GALR1 TPH2	1.03e-03	25	56	2	C1571984
Disease	Involutional Depression	GALR1 TPH2	1.03e-03	25	56	2	C0011574
Disease	platelet component distribution width	ZNF490 DOCK5 LNX2 U2SURP ABCC5 WNK1	3.01e-03	755	56	6	EFO_0007984
Disease	mean platelet volume	DOCK5 DCANP1 LNX2 ARGFX U2SURP RSF1 ABCC5	3.06e-03	1020	56	7	EFO_0004584

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSERSHRSSCERTRH	C2orf16	1896	Q68DN1
DELHSSRRKTGQTRR	DCANP1	111	Q8TF63
RSSDRSRDSSHERTE	BTBD10	66	Q9BSF8
TERKHSSLERARSVH	CCDC187	431	A0A096LP49
SRHRRVRTEGKESSS	CACNA1E	921	Q15878
KHKRRRSRSWSSSSD	CLK2	26	P49760
GRTFTDKSTLRRHTS	GZF1	581	Q9H116
ATTAIRRRHKERTSF	ARGFX	71	A6NJG6
RVETSSHRVETSSRR	C17orf100	26	A8MU93
TSRHVRASSLRVETS	C17orf100	81	A8MU93
AKRSRSRTATECDVR	SPECC1L	151	Q69YQ0
SHRRTGSRAEAKRAS	ATP10A	501	O60312
HKSSSRREAREEKTR	RBMX2	251	Q9Y388
SDSDRHRSREKLTST	QRICH2	171	Q9H0J4
CRSVRERESHSRKSA	DEPDC5	481	O75140
HSLRRSRFSESESRS	KIAA1671	1661	Q9BY89
SHRRVALERRKTSRT	LNX2	141	Q8N448
YSVVHRTSKRSEARS	FCRL6	371	Q6DN72
TRRTSIHDFLTKDSR	CCDC88A	1816	Q3V6T2
KEETRHKSSRSNSRR	FIP1L1	536	Q6UN15
RRSEKDSSHSGRSVV	ILDR1	531	Q86SU0
RETSVSKTHRSADRA	NUTM1	986	Q86Y26
RERTSTSGTHRDRED	ABCC5	21	O15440
TSGTHRDREDSKFRR	ABCC5	26	O15440
AIVHSRRSSSLRVSR	GALR1	136	P47211
FRHRSSQETRDKSER	DOCK5	531	Q9H7D0
SEVHVRTTRSASSRR	BMP6	366	P22004
SVHSKRRSRADLTAE	CDC42EP4	11	Q9H3Q1
KTRTSRRAAEHRDTT	ABL1	531	P00519
TGRKSHSLDSLSRRR	CCDC177	226	Q9NQR7
HRPRTIRDRTSFSSK	ERCC6L2	1071	Q5T890
ERRHSKTHTSVRALT	FARP2	366	O94887
DSRRTTTRHSKTMEE	CDKL5	556	O76039
IRRVHKRRLSSSESE	RSF1	1236	Q96T23
AKKVAVRSRSRTHSR	SCAF8	391	Q9UPN6
SRSQHEESRTARVIR	RYR2	406	Q92736
FSTTRRCTTRRKHDD	CFAP47	2486	Q6ZTR5
CRSSHSERKSNIRTR	MAP3K19	701	Q56UN5
SRHSKSSSDRSRKRE	PRPF3	76	O43395
RSRSRSAAAKTHTTA	SRRM2	276	Q9UQ35
SSESELEHERSRRRK	NKTR	211	P30414
RRRRASHPTAESSSE	SECISBP2L	246	Q93073
KKRSEARRHRDSTSQ	SPATA3	6	Q8NHX4
LIEGSKRHSRSRSRS	SRSF5	176	Q13243
PRKSRDSESHSRVRE	SAFB	611	Q15424
DSESHSRVRERSERE	SAFB	616	Q15424
SERSERSERSHKESS	U2SURP	951	O15042
RSERSHKESSRSRSS	U2SURP	956	O15042
AVESKSRHRSRSLGV	NCAPD3	1361	P42695
KSRESVDSRDSSHSR	THRAP3	736	Q9Y2W1
RIHTGEKTVRRSRAS	ZNF324	501	O75467
SSSLRRHVRIHTTEK	ZNF555	576	Q8NEP9
KTFTRSSSIRTHERI	ZNF490	201	Q9ULM2
TRSSRSGHLAKETRV	RGS18	61	Q9NS28
ESDSSLSEVHRSSRR	KIF21A	1306	Q7Z4S6
AASLKSRSSEGRHRR	SYCP2	536	Q9BX26
RASLTRLKSRASHTR	nan	76	A8MUU9
ASLTRSKSRASHTRT	nan	361	A8MUU9
MVHIESRKSRRRSSE	TPH2	91	Q8IWU9
STSRSRSRSSDHGKR	TOPORS	666	Q9NS56
RTSVSRHRDTENTRS	ZFP91	156	Q96JP5
RHRDTENTRSSRSKT	ZFP91	161	Q96JP5
KSRTSDHSLSREGSR	USP31	1146	Q70CQ4
RSRRTICVKTHESGR	WSCD1	401	Q658N2
RTTKRHYRKSVRSRS	WNK1	1096	Q9H4A3
RRRTTVHSRDKQSGT	TMC7	51	Q7Z402