Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribosomal protein S6 kinase activity	RPS6KA2 RPS6KA3 RPS6KA6	7.25e-07	7	56	3	GO:0004711
GeneOntologyMolecularFunction	protein-disulfide reductase activity	TXNRD1 QSOX1 TMX3 STAB1	3.06e-06	36	56	4	GO:0015035
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	TXNRD1 QSOX1 TMX3 STAB1	6.31e-06	43	56	4	GO:0015036
GeneOntologyMolecularFunction	histidine-tRNA ligase activity	HARS2 HARS1	7.73e-06	2	56	2	GO:0004821
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors	TXNRD1 QSOX1 TMX3 STAB1	1.96e-05	57	56	4	GO:0016667
GeneOntologyMolecularFunction	protein serine kinase activity	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	6.68e-05	363	56	7	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	2.39e-04	446	56	7	GO:0004674
GeneOntologyMolecularFunction	FAD binding	TXNRD1 QSOX1 NQO2	2.55e-04	44	56	3	GO:0071949
GeneOntologyMolecularFunction	G protein activity	RAB10 RAB1B RAB8A	6.08e-04	59	56	3	GO:0003925
GeneOntologyMolecularFunction	magnesium ion binding	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	6.35e-04	247	56	5	GO:0000287
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK G6PC1	7.65e-04	709	56	8	GO:0016773
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN2 CAPN6	1.02e-03	17	56	2	GO:0004198
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK G6PC1 PIGO	1.11e-03	938	56	9	GO:0016772
GeneOntologyMolecularFunction	oxidoreductase activity	TXNRD1 QSOX1 CYP27B1 ASPH TMX3 NQO2 F8 STAB1	1.26e-03	766	56	8	GO:0016491
GeneOntologyMolecularFunction	protein kinase activity	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	1.38e-03	600	56	7	GO:0004672
GeneOntologyMolecularFunction	myosin V binding	RAB10 RAB8A	1.42e-03	20	56	2	GO:0031489
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing S-S bonds	QSOX1 TMX3	1.72e-03	22	56	2	GO:0016864
GeneOntologyMolecularFunction	protein disulfide isomerase activity	QSOX1 TMX3	1.72e-03	22	56	2	GO:0003756
GeneOntologyMolecularFunction	myosin binding	RAB10 MYO19 RAB8A	1.75e-03	85	56	3	GO:0017022
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	MALT1 CAPN2 CAPN6	1.81e-03	86	56	3	GO:0004197
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	TXNRD1 QSOX1 NQO2	2.34e-03	94	56	3	GO:0050660
GeneOntologyMolecularFunction	GDP binding	RAB10 RAB8B RAB8A	3.03e-03	103	56	3	GO:0019003
GeneOntologyMolecularFunction	kinase activity	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	5.31e-03	764	56	7	GO:0016301
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RAB10 ABCA2 RAB8B MYO19 RAB1B DNAH7 RAB8A	5.73e-03	775	56	7	GO:0017111
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	HARS2 HARS1	6.19e-03	42	56	2	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	HARS2 HARS1	6.19e-03	42	56	2	GO:0004812
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC9A9 SLC8A1	6.48e-03	43	56	2	GO:0140828
GeneOntologyMolecularFunction	pyrophosphatase activity	RAB10 ABCA2 RAB8B MYO19 RAB1B DNAH7 RAB8A	8.72e-03	839	56	7	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RAB10 ABCA2 RAB8B MYO19 RAB1B DNAH7 RAB8A	8.77e-03	840	56	7	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RAB10 ABCA2 RAB8B MYO19 RAB1B DNAH7 RAB8A	8.77e-03	840	56	7	GO:0016818
GeneOntologyBiologicalProcess	histidyl-tRNA aminoacylation	HARS2 HARS1	6.98e-06	2	55	2	GO:0006427
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	RPS6KA5 RPS6KA2 RPS6KA3 TENM1 RPS6KA6 PRKCD DMPK	1.66e-05	307	55	7	GO:0018105
GeneOntologyBiologicalProcess	peptidyl-serine modification	RPS6KA5 RPS6KA2 RPS6KA3 TENM1 RPS6KA6 PRKCD DMPK	2.13e-05	319	55	7	GO:0018209
GeneOntologyBiologicalProcess	intracellular transport	RAB10 MALT1 ABCA2 DNAJC13 CDC42BPA RAB8B MYO19 ASPH TENM1 PRKCD CD81 RAB1B BBS12 RAB8A	2.71e-05	1496	55	14	GO:0046907
GeneOntologyBiologicalProcess	phospholipid metabolic process	TTC7A ABCA2 PLA2G4B CAPN2 PRKCD HMGCS2 PIGO	1.04e-04	410	55	7	GO:0006644
GeneOntologyBiologicalProcess	protein localization to cell periphery	TTC7A RAB10 ABCA2 LAMA5 CD81 NBEA RAB8A	1.24e-04	422	55	7	GO:1990778
GeneOntologyBiologicalProcess	regulation of phospholipid metabolic process	ABCA2 CAPN2 PRKCD	1.65e-04	40	55	3	GO:1903725
GeneOntologyBiologicalProcess	regulation of intracellular transport	ABCA2 DNAJC13 ASPH TENM1 PRKCD CD81	1.84e-04	314	55	6	GO:0032386
GeneOntologyCellularComponent	extracellular matrix of synaptic cleft	LAMA5 TNR	2.11e-05	3	56	2	GO:0098965
GeneOntologyCellularComponent	phagocytic vesicle membrane	RAB10 SLC9A9 RAB8B RAB8A	7.25e-05	83	56	4	GO:0030670
GeneOntologyCellularComponent	recycling endosome membrane	RAB10 SLC9A9 RAB8B RAB8A	2.31e-04	112	56	4	GO:0055038
GeneOntologyCellularComponent	endocytic vesicle membrane	RAB10 SLC9A9 RAB8B RAB8A STAB1	2.57e-04	212	56	5	GO:0030666
GeneOntologyCellularComponent	synapse-associated extracellular matrix	LAMA5 TNR	5.39e-04	13	56	2	GO:0099535
GeneOntologyCellularComponent	perinuclear region of cytoplasm	RAB10 MALT1 KLHL7 RAB8B CAPN2 CAPN6 TENM1 PRKCD RAB1B	7.81e-04	934	56	9	GO:0048471
GeneOntologyCellularComponent	phagocytic vesicle	RAB10 SLC9A9 RAB8B RAB8A	8.30e-04	157	56	4	GO:0045335
GeneOntologyCellularComponent	endosome membrane	RAB10 SLC9A9 ABCA2 DNAJC13 PLA2G4B RAB8B RAB8A	1.08e-03	602	56	7	GO:0010008
MousePheno	absent Z line	SLC8A1 DMPK	3.46e-05	3	48	2	MP:0004092
MousePheno	abnormal primitive streak formation	TXNRD1 RAB10 HARS2 RPS6KA6 UBIAD1	4.65e-05	116	48	5	MP:0002230
Domain	Pkinase_C	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	3.67e-11	42	56	7	PF00433
Domain	AGC-kinase_C	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	3.06e-10	56	56	7	IPR000961
Domain	AGC_KINASE_CTER	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	3.06e-10	56	56	7	PS51285
Domain	S_TK_X	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	3.06e-10	56	56	7	SM00133
Domain	Ribosomal_S6_kinase_II	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	1.08e-09	6	56	4	IPR016239
Domain	Pkinase_C	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD	1.19e-09	37	56	6	IPR017892
Domain	His-tRNA-ligase	HARS2 HARS1	8.83e-06	2	56	2	IPR015807
Domain	HisRS_anticodon	HARS2 HARS1	8.83e-06	2	56	2	IPR033656
Domain	HisRS/HisZ	HARS2 HARS1	8.83e-06	2	56	2	IPR004516
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPA DMPK	5.28e-05	4	56	2	IPR014930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPA DMPK	5.28e-05	4	56	2	PD011252
Domain	DMPK_coil	CDC42BPA DMPK	5.28e-05	4	56	2	PF08826
Domain	RAB	RAB10 RAB8B RAB1B RAB8A	6.76e-05	73	56	4	PS51419
Domain	Ser/Thr_kinase_AS	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	9.11e-05	357	56	7	IPR008271
Domain	S_TKc	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	9.44e-05	359	56	7	SM00220
Domain	PROTEIN_KINASE_ST	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	9.94e-05	362	56	7	PS00108
Domain	Protein_kinase_ATP_BS	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	1.32e-04	379	56	7	IPR017441
Domain	Pkinase	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	1.36e-04	381	56	7	PF00069
Domain	HGTP_anticodon	HARS2 HARS1	3.14e-04	9	56	2	PF03129
Domain	PROTEIN_KINASE_ATP	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	4.24e-04	459	56	7	PS00107
Domain	aa-tRNA-synt_IIb	HARS2 HARS1	4.77e-04	11	56	2	IPR002314
Domain	tRNA-synt_2b	HARS2 HARS1	4.77e-04	11	56	2	PF00587
Domain	-	HARS2 HARS1	4.77e-04	11	56	2	3.40.50.800
Domain	Calpain_III	CAPN2 CAPN6	5.72e-04	12	56	2	IPR022683
Domain	calpain_III	CAPN2 CAPN6	5.72e-04	12	56	2	SM00720
Domain	C2_III	CAPN2 CAPN6	5.72e-04	12	56	2	IPR033883
Domain	Prot_kinase_dom	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	6.18e-04	489	56	7	IPR000719
Domain	PROTEIN_KINASE_DOM	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	6.48e-04	493	56	7	PS50011
Domain	Calpain_domain_III	CAPN2 CAPN6	6.74e-04	13	56	2	IPR022682
Domain	Calpain_III	CAPN2 CAPN6	6.74e-04	13	56	2	PF01067
Domain	Ras	RAB10 RAB8B RAB1B RAB8A	7.37e-04	136	56	4	PF00071
Domain	EGF_extracell	TENM1 TNR STAB1	7.74e-04	60	56	3	IPR013111
Domain	EGF_2	TENM1 TNR STAB1	7.74e-04	60	56	3	PF07974
Domain	Calpain_cysteine_protease	CAPN2 CAPN6	7.85e-04	14	56	2	IPR022684
Domain	Anticodon-bd	HARS2 HARS1	7.85e-04	14	56	2	IPR004154
Domain	CysPc	CAPN2 CAPN6	9.04e-04	15	56	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN2 CAPN6	9.04e-04	15	56	2	IPR001300
Domain	Peptidase_C2	CAPN2 CAPN6	9.04e-04	15	56	2	PF00648
Domain	CALPAIN_CAT	CAPN2 CAPN6	9.04e-04	15	56	2	PS50203
Domain	Kinase-like_dom	CDC42BPA RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD DMPK	1.13e-03	542	56	7	IPR011009
Domain	aa-tRNA-synth_II	HARS2 HARS1	1.31e-03	18	56	2	IPR006195
Domain	AA_TRNA_LIGASE_II	HARS2 HARS1	1.31e-03	18	56	2	PS50862
Domain	Small_GTPase	RAB10 RAB8B RAB1B RAB8A	1.35e-03	160	56	4	IPR001806
Domain	Small_GTP-bd_dom	RAB10 RAB8B RAB1B RAB8A	1.58e-03	167	56	4	IPR005225
Domain	FA58C	RS1 F8	1.79e-03	21	56	2	SM00231
Domain	FA58C_3	RS1 F8	1.79e-03	21	56	2	PS50022
Domain	FA58C_1	RS1 F8	1.79e-03	21	56	2	PS01285
Domain	FA58C_2	RS1 F8	1.79e-03	21	56	2	PS01286
Domain	F5_F8_type_C	RS1 F8	2.34e-03	24	56	2	PF00754
Domain	FA58C	RS1 F8	2.34e-03	24	56	2	IPR000421
Domain	THIOL_PROTEASE_CYS	CAPN2 CAPN6	2.74e-03	26	56	2	PS00139
Domain	Galactose-bd-like	LAMA5 RS1 F8	2.82e-03	94	56	3	IPR008979
Domain	THIOL_PROTEASE_ASN	CAPN2 CAPN6	2.95e-03	27	56	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN2 CAPN6	2.95e-03	27	56	2	PS00639
Domain	Pept_cys_AS	CAPN2 CAPN6	3.17e-03	28	56	2	IPR000169
Domain	EGF_LAM_2	LAMA5 STAB1	3.64e-03	30	56	2	PS50027
Domain	EGF_LAM_1	LAMA5 STAB1	3.64e-03	30	56	2	PS01248
Domain	Thioredoxin	QSOX1 TMX3	3.88e-03	31	56	2	PF00085
Domain	Laminin_EGF	LAMA5 STAB1	4.93e-03	35	56	2	PF00053
Domain	EGF_Lam	LAMA5 STAB1	4.93e-03	35	56	2	SM00180
Domain	EGF	TENM1 LAMA5 TNR STAB1	5.38e-03	235	56	4	SM00181
Domain	Laminin_EGF	LAMA5 STAB1	5.79e-03	38	56	2	IPR002049
Domain	-	TXNRD1 QSOX1 TMX3	5.86e-03	122	56	3	3.40.30.10
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA2 RPS6KA3 RPS6KA6	3.69e-07	5	48	3	MM15108
Pathway	KEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING	RPS6KA2 RPS6KA3 RPS6KA6	7.36e-07	6	48	3	M47936
Pathway	REACTOME_RSK_ACTIVATION	RPS6KA2 RPS6KA3 RPS6KA6	1.28e-06	7	48	3	M27369
Pathway	REACTOME_CREB_PHOSPHORYLATION	RPS6KA5 RPS6KA2 RPS6KA3	1.28e-06	7	48	3	M27096
Pathway	REACTOME_CREB_PHOSPHORYLATION	RPS6KA5 RPS6KA2 RPS6KA3	1.28e-06	7	48	3	MM14784
Pathway	REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	RPS6KA2 RPS6KA3 RPS6KA6	1.64e-05	15	48	3	MM15103
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	2.24e-05	49	48	4	M891
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA5 RPS6KA2 RPS6KA3	3.46e-05	19	48	3	MM14780
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA5 RPS6KA2 RPS6KA3	5.45e-05	22	48	3	M13408
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD	6.63e-05	126	48	5	M16763
Pathway	REACTOME_RAB_GERANYLGERANYLATION	RAB10 RAB8B RAB1B RAB8A	6.88e-05	65	48	4	M27771
Pathway	REACTOME_RAB_GERANYLGERANYLATION	RAB10 RAB8B RAB1B RAB8A	6.88e-05	65	48	4	MM15511
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 G6PC1	8.27e-05	132	48	5	M39338
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	RPS6KA5 RPS6KA2 RPS6KA3	1.02e-04	27	48	3	MM14779
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	RPS6KA5 RPS6KA2 RPS6KA3	1.14e-04	28	48	3	MM15132
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA2 RPS6KA3 RPS6KA6	1.14e-04	28	48	3	M837
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	RPS6KA5 RPS6KA2 RPS6KA3	1.56e-04	31	48	3	M15195
Pathway	WP_INSULIN_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD	2.04e-04	160	48	5	M39482
Pathway	WP_INSULIN_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD	2.04e-04	160	48	5	MM15956
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	RPS6KA2 RPS6KA3 RPS6KA6	2.25e-04	35	48	3	MM15109
Pathway	REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS	RAB10 RAB8B RAB1B RAB8A	2.44e-04	90	48	4	M27779
Pathway	REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS	RAB10 RAB8B RAB1B RAB8A	2.54e-04	91	48	4	MM15518
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	RPS6KA2 RPS6KA3 RPS6KA6 NBEA	2.88e-04	94	48	4	M2843
Pathway	PID_ERBB1_DOWNSTREAM_PATHWAY	RPS6KA5 RPS6KA3 CAPN2 PRKCD	4.40e-04	105	48	4	M164
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	RPS6KA5 RPS6KA2 PRKCD	5.07e-04	46	48	3	M39805
Pathway	REACTOME_RAB_REGULATION_OF_TRAFFICKING	RAB10 RAB8B RAB1B RAB8A	6.83e-04	118	48	4	MM15589
Pathway	KEGG_MTOR_SIGNALING_PATHWAY	RPS6KA2 RPS6KA3 RPS6KA6	7.28e-04	52	48	3	M7561
Pathway	REACTOME_L1CAM_INTERACTIONS	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	7.51e-04	121	48	4	M872
Pathway	REACTOME_RAB_REGULATION_OF_TRAFFICKING	RAB10 RAB8B RAB1B RAB8A	7.74e-04	122	48	4	M27872
Pathway	REACTOME_ION_HOMEOSTASIS	SLC8A1 ASPH DMPK	8.14e-04	54	48	3	M27460
Pathway	REACTOME_ION_HOMEOSTASIS	SLC8A1 ASPH DMPK	8.14e-04	54	48	3	MM15202
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3	1.05e-03	59	48	3	MM15128
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	RPS6KA5 RPS6KA2 RPS6KA3	1.16e-03	61	48	3	M152
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	RPS6KA5 RPS6KA2 RPS6KA3	1.27e-03	63	48	3	MM14714
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	RPS6KA2 RPS6KA3	1.32e-03	16	48	2	MM15477
Pathway	REACTOME_INNATE_IMMUNE_SYSTEM	QSOX1 RAB10 MALT1 DNAJC13 RPS6KA5 RPS6KA2 RPS6KA3 PRKCD CD81 LTA4H	1.63e-03	995	48	10	MM14661
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	RPS6KA2 RPS6KA3	1.68e-03	18	48	2	M657
Pathway	KEGG_LONG_TERM_POTENTIATION	RPS6KA2 RPS6KA3 RPS6KA6	1.73e-03	70	48	3	M3115
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3	1.80e-03	71	48	3	M27382
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	RPS6KA5 PLA2G4B RPS6KA2 RPS6KA3 RPS6KA6	2.07e-03	267	48	5	M10792
Pathway	REACTOME_SIGNALING_BY_NTRKS	RPS6KA5 RPS6KA2 RPS6KA3	2.11e-03	75	48	3	MM14652
Pathway	BIOCARTA_MAPK_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3	2.19e-03	76	48	3	MM1433
Pathway	WP_EGFEGFR_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3 PRKCD	2.21e-03	162	48	4	M39334
Pathway	BIOCARTA_MAPK_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3	2.62e-03	81	48	3	M13863
Pathway	WP_EICOSANOID_SYNTHESIS	PLA2G4B LTA4H	2.74e-03	23	48	2	M39382
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	RPS6KA2 RPS6KA3 RPS6KA6	3.01e-03	85	48	3	M3578
Pathway	REACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE	RPS6KA5 RPS6KA2 RPS6KA3	3.01e-03	85	48	3	MM14645
Pathway	WP_CYTOPLASMIC_RIBOSOMAL_PROTEINS	RPS6KA2 RPS6KA3 RPS6KA6	3.32e-03	88	48	3	M39495
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	HARS2 CDC42BPA RPS6KA5 PLA2G4B RPS6KA2 RPS6KA3 CAPN2 CAPN6 RPS6KA6 PRKCD HARS1 DMPK	1.60e-09	730	56	12	34857952
Pubmed	Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.	RAB10 RAB8B RAB8A	1.58e-08	4	56	3	24213529
Pubmed	RSK2 is a modulator of craniofacial development.	RPS6KA2 RPS6KA3 RPS6KA6	3.94e-08	5	56	3	24416220
Pubmed	The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.	RPS6KA2 RPS6KA3 RPS6KA6	3.94e-08	5	56	3	37068088
Pubmed	Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.	RPS6KA2 RPS6KA3 RPS6KA6	3.94e-08	5	56	3	11160957
Pubmed	Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.	RPS6KA2 RPS6KA3 RPS6KA6	7.88e-08	6	56	3	12832467
Pubmed	GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.	RAB10 RAB8B RAB8A	3.30e-07	9	56	3	32344433
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	RAB10 RAB8B RAB1B RAB8A	3.83e-07	37	56	4	20937701
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	RAB10 DNAJC13 CDC42BPA RAB8B CAPN2 LAMA5 PRKCD CD81 LTA4H NQO2 RAB8A	5.60e-07	1016	56	11	19056867
Pubmed	Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.	RAB10 RAB1B RAB8A	8.61e-07	12	56	3	26824392
Pubmed	EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.	RAB10 RAB8B RAB8A	1.12e-06	13	56	3	26833786
Pubmed	Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.	RPS6KA5 RPS6KA2 RPS6KA3	1.42e-06	14	56	3	9687510
Pubmed	Cytoplasmic control of Rab family small GTPases through BAG6.	RAB10 RAB1B RAB8A	1.77e-06	15	56	3	30804014
Pubmed	Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.	RAB10 RAB8B RAB1B RAB8A	2.40e-06	58	56	4	11856727
Pubmed	RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.	RPS6KA2 RPS6KA6	2.55e-06	2	56	2	23635776
Pubmed	Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome.	HARS2 HARS1	2.55e-06	2	56	2	21464306
Pubmed	A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS.	HARS2 HARS1	2.55e-06	2	56	2	7755634
Pubmed	Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element.	HARS2 HARS1	2.55e-06	2	56	2	8406012
Pubmed	MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit.	RPS6KA2 RPS6KA3	2.55e-06	2	56	2	11495723
Pubmed	Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases.	HARS2 HARS1	2.55e-06	2	56	2	1549469
Pubmed	EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.	RAB10 RAB8B RAB8A	2.65e-06	17	56	3	37042948
Pubmed	Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.	RAB10 RAB8B RAB1B RAB8A	2.94e-06	61	56	4	12578829
Pubmed	The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.	RAB10 RAB8B RAB1B RAB8A	3.14e-06	62	56	4	11773082
Pubmed	Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.	RAB10 RAB8B RAB1B RAB8A	5.72e-06	72	56	4	16923123
Pubmed	The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.	RAB10 RAB8A	7.63e-06	3	56	2	38307024
Pubmed	Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.	RPS6KA5 RPS6KA2	7.63e-06	3	56	2	33709453
Pubmed	Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.	RAB8B RAB8A	7.63e-06	3	56	2	28076793
Pubmed	Protein LidA from Legionella is a Rab GTPase supereffector.	RAB1B RAB8A	7.63e-06	3	56	2	22011575
Pubmed	Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer.	RAB8B RAB8A	7.63e-06	3	56	2	31707148
Pubmed	EGF receptor and PKCδ kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases.	RPS6KA5 PRKCD	7.63e-06	3	56	2	30679314
Pubmed	Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning.	RPS6KA2 RPS6KA3	7.63e-06	3	56	2	12393804
Pubmed	Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.	RPS6KA2 RPS6KA3	7.63e-06	3	56	2	12016217
Pubmed	A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.	RAB8B RAB8A	7.63e-06	3	56	2	12221131
Pubmed	A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.	CAPN2 CAPN6	7.63e-06	3	56	2	9339374
Pubmed	Human rsk isoforms: cloning and characterization of tissue-specific expression.	RPS6KA2 RPS6KA3	7.63e-06	3	56	2	8141249
Pubmed	The Clinical Implications of RSK1-3 in Human Breast Cancer.	RPS6KA2 RPS6KA3	7.63e-06	3	56	2	26977024
Pubmed	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.	RAB8B RAB8A	1.52e-05	4	56	2	26471730
Pubmed	Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.	RPS6KA5 PRKCD	1.52e-05	4	56	2	14963018
Pubmed	Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli.	RAB10 RAB8A	1.52e-05	4	56	2	19116169
Pubmed	RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.	RPS6KA2 RPS6KA3	1.52e-05	4	56	2	7623830
Pubmed	Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.	RPS6KA2 RPS6KA3	1.52e-05	4	56	2	9770464
Pubmed	Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.	CDC42BPA DMPK	1.52e-05	4	56	2	21457715
Pubmed	RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.	RAB10 RAB8A	1.52e-05	4	56	2	31428781
Pubmed	p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.	RPS6KA2 RPS6KA3	1.52e-05	4	56	2	21527514
Pubmed	A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.	RAB10 RAB8A	1.52e-05	4	56	2	30398148
Pubmed	RAB GTPases expressed in human melanoma cells.	RAB8B RAB1B	1.52e-05	4	56	2	9030196
Pubmed	Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis.	RPS6KA3 RPS6KA6	1.52e-05	4	56	2	12711546
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	QSOX1 RAB10 DNAJC13 CDC42BPA ASPH PRKCD HARS1 RAB8A	2.16e-05	732	56	8	34732716
Pubmed	Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.	RPS6KA3 TMX3 DMPK TNR	2.37e-05	103	56	4	11752456
Pubmed	90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.	RPS6KA2 RPS6KA3	2.54e-05	5	56	2	10480933
Pubmed	Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.	RPS6KA2 RPS6KA3	2.54e-05	5	56	2	15526037
Pubmed	Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.	RAB10 RAB8A	2.54e-05	5	56	2	32017888
Pubmed	AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.	RAB10 RAB8A	2.54e-05	5	56	2	15971998
Pubmed	Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.	RPS6KA2 RPS6KA3	2.54e-05	5	56	2	16217014
Pubmed	Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.	RPS6KA2 RPS6KA3	2.54e-05	5	56	2	9915826
Pubmed	The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.	RPS6KA5 RPS6KA3	2.54e-05	5	56	2	17906627
Pubmed	The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.	RAB8B RAB8A	2.54e-05	5	56	2	18094055
Pubmed	Chromosomal protein HMGN1 modulates histone H3 phosphorylation.	RPS6KA5 RPS6KA3	2.54e-05	5	56	2	15327773
Pubmed	The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.	RPS6KA2 RPS6KA3	2.54e-05	5	56	2	15867353
Pubmed	Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.	RPS6KA5 RPS6KA2	2.54e-05	5	56	2	10635333
Pubmed	A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.	RAB1B RAB8A	2.54e-05	5	56	2	21378754
Pubmed	Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD).	IL1RAPL2 RPS6KA6	2.54e-05	5	56	2	21384559
Pubmed	Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.	RAB10 RAB8B CD81 RAB1B TNR	2.55e-05	215	56	5	36808153
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	RPS6KA5 RPS6KA2 RPS6KA3 LAMA5 PRKCD F8	2.93e-05	371	56	6	25241761
Pubmed	Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.	MALT1 PRKCD	3.80e-05	6	56	2	27926862
Pubmed	Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome.	MALT1 PRKCD	3.80e-05	6	56	2	22528498
Pubmed	STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.	RPS6KA5 PRKCD	3.80e-05	6	56	2	9343414
Pubmed	Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.	RPS6KA2 RPS6KA3	3.80e-05	6	56	2	8688081
Pubmed	Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK).	RPS6KA5 PRKCD	3.80e-05	6	56	2	9872331
Pubmed	Serine phosphorylation and negative regulation of Stat3 by JNK.	RPS6KA5 PRKCD	3.80e-05	6	56	2	10521505
Pubmed	Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.	RPS6KA5 RPS6KA3	3.80e-05	6	56	2	11297520
Pubmed	NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.	RPS6KA2 RPS6KA3	3.80e-05	6	56	2	11175347
Pubmed	The MAP kinase ERK5 binds to and phosphorylates p90 RSK.	RPS6KA2 RPS6KA3	3.80e-05	6	56	2	16626623
Pubmed	Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.	RPS6KA2 RPS6KA3	3.80e-05	6	56	2	8939914
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	TXNRD1 DNAJC13 ASPH SLC39A10 TMX3	3.89e-05	235	56	5	32614325
Pubmed	Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.	CD81 HMGCS2	5.32e-05	7	56	2	23665349
Pubmed	Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.	RAB1B RAB8A	5.32e-05	7	56	2	26209634
Pubmed	Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.	RPS6KA5 RPS6KA2	5.32e-05	7	56	2	10880354
Pubmed	Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.	RPS6KA5 RPS6KA3	5.32e-05	7	56	2	11157753
Pubmed	MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.	CDC42BPA DMPK	5.32e-05	7	56	2	29162624
Pubmed	Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.	RPS6KA5 PRKCD	5.32e-05	7	56	2	12763138
Pubmed	Structure and physiological function of calpains.	CAPN2 CAPN6	5.32e-05	7	56	2	9396712
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	RAB10 RAB8B RPS6KA2 CAPN2 PRKCD RAB1B RAB8A	6.08e-05	621	56	7	22794259
Pubmed	MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.	RPS6KA5 RPS6KA3	7.09e-05	8	56	2	12773393
Pubmed	Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.	RAB10 RAB8A	7.09e-05	8	56	2	9918381
Pubmed	Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.	RAB10 RAB8A	7.09e-05	8	56	2	29125462
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN2 CAPN6	7.09e-05	8	56	2	9473662
Pubmed	CREB is a regulatory target for the protein kinase Akt/PKB.	RPS6KA2 RPS6KA3	7.09e-05	8	56	2	9829964
Pubmed	Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.	RPS6KA5 RPS6KA3	7.09e-05	8	56	2	16223362
Pubmed	Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.	RPS6KA5 RPS6KA3	9.10e-05	9	56	2	17512525
Pubmed	P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.	RPS6KA2 RPS6KA3	9.10e-05	9	56	2	19555761
Pubmed	Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.	RPS6KA5 RPS6KA3	1.14e-04	10	56	2	29229781
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KBTBD3 RAB10 MALT1 DNAJC13 CDC42BPA RPS6KA2 ASPH TMX3 NQO2 NAALADL2	1.18e-04	1489	56	10	28611215
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RAB10 DNAJC13 RAB8B ASPH CD81 UBIAD1 SLC39A10 TMX3 RAB8A	1.21e-04	1203	56	9	29180619
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	RPS6KA2 RPS6KA3 RPS6KA6 SLC39A10	1.32e-04	160	56	4	31678930
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	QSOX1 ABCA2 LAMA5 TMX3	1.45e-04	164	56	4	32409323
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	QSOX1 DNAJC13 ASPH UBIAD1 TMX3 PIGO	1.50e-04	499	56	6	22810586
Pubmed	Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.	RAB8B RAB8A	1.66e-04	12	56	2	18329369
Pubmed	Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.	HMGCS2 G6PC1	1.66e-04	12	56	2	24717294
Pubmed	Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.	RPS6KA5 PRKCD	1.66e-04	12	56	2	12576423
Interaction	RABIF interactions	RAB10 RAB8B RPS6KA3 RAB1B RAB8A	3.01e-06	81	56	5	int:RABIF
Interaction	PRRT2 interactions	RAB10 RAB8B CD81 RAB1B DDI1 TNR	3.26e-05	220	56	6	int:PRRT2
Interaction	RPS6KB1 interactions	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 NQO2	4.79e-05	143	56	5	int:RPS6KB1
Interaction	MICAL1 interactions	RAB10 KLHL7 RPS6KA6 RAB1B	6.88e-05	79	56	4	int:MICAL1
Interaction	STRADB interactions	RPS6KA2 RPS6KA3 NBEA	7.05e-05	29	56	3	int:STRADB
Interaction	GGA2 interactions	RAB10 RPS6KA3 RPS6KA6 STAB1	8.75e-05	84	56	4	int:GGA2
Interaction	AKT3 interactions	RPS6KA5 RPS6KA2 RPS6KA3 PRKCD	9.16e-05	85	56	4	int:AKT3
Interaction	RHOB interactions	RAB10 CDC42BPA RAB8B PRKCD CD81 NBEA UBIAD1 SLC39A10 NQO2 RAB8A	9.36e-05	840	56	10	int:RHOB
Cytoband	2q32.3	SLC39A10 DNAH7	9.57e-05	12	56	2	2q32.3
Cytoband	1q24	QSOX1 TNR	2.74e-04	20	56	2	1q24
Cytoband	5q31.3	HARS2 HARS1	8.96e-04	36	56	2	5q31.3
Cytoband	11q22.3	KBTBD3 DDI1	1.34e-03	44	56	2	11q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	KBTBD3 DDI1	7.63e-03	107	56	2	chr11q22
Cytoband	Ensembl 112 genes in cytogenetic band chr2q32	SLC39A10 DNAH7	8.05e-03	110	56	2	chr2q32
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	6.70e-09	11	40	4	1156
GeneFamily	RAB, member RAS oncogene GTPases	RAB10 RAB8B RAB1B RAB8A	1.26e-05	65	40	4	388
GeneFamily	C2 domain containing\|Calpains	CAPN2 CAPN6	4.92e-04	15	40	2	975
GeneFamily	Aminoacyl tRNA synthetases, Class II	HARS2 HARS1	7.97e-04	19	40	2	132
Coexpression	XU_GH1_AUTOCRINE_TARGETS_DN	CDC42BPA LAMA5 NBEA SLC39A10 NAALADL2	8.99e-06	131	56	5	M16384
Coexpression	ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_UP	TTC7A QSOX1 RAB10 SLC9A9 SLC8A1 DNAJC13 PRKCD NQO2 RAB8A STAB1	4.98e-05	1012	56	10	M40868
Coexpression	RAF_UP.V1_UP	MALT1 KLHL7 CAPN2 CAPN6 ASPH	5.79e-05	193	56	5	M2728
Coexpression	GSE18281_CORTICAL_THYMOCYTE_VS_WHOLE_CORTEX_THYMUS_UP	IL1RAPL2 MYO19 CAPN6 RS1 TNR	6.23e-05	196	56	5	M7238
Coexpression	GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_UP	SLC8A1 KLHL7 LTA4H NBEA UBIAD1	6.38e-05	197	56	5	M6278
Coexpression	SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4	CDC42BPA RPS6KA2 CAPN2 PRKCD LTA4H	6.38e-05	197	56	5	M12824
Coexpression	GSE360_T_GONDII_VS_B_MALAYI_HIGH_DOSE_MAC_DN	ABCA2 PRKCD LTA4H PIGO STAB1	6.69e-05	199	56	5	M5255
Coexpression	GSE3982_MAST_CELL_VS_EFF_MEMORY_CD4_TCELL_UP	TXNRD1 CDC42BPA NBEA NQO2 STAB1	6.69e-05	199	56	5	M5441
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN6 NBEA TNR F8 STAB1	4.41e-06	193	56	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	QSOX1 RAB10 SLC8A1 LTA4H STAB1	4.87e-06	197	56	5	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
Drug	Ovta	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	3.22e-08	14	56	4	CID003081047
Drug	AD 288	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	3.22e-08	14	56	4	CID000073553
Drug	R165481	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	5.84e-08	16	56	4	CID005459348
Drug	AC1MS9WM	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	5.52e-07	27	56	4	CID003530978
Drug	K00085	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	5.52e-07	27	56	4	CID009549283
Drug	A61603	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	1.27e-06	33	56	4	CID004038180
Drug	clotrimazole	ABCA2 RPS6KA2 RPS6KA3 CYP27B1 RPS6KA6 LTA4H	1.39e-06	143	56	6	CID000002812
Drug	BI D1870	RPS6KA2 RPS6KA3 RPS6KA6	2.29e-06	11	56	3	ctd:C516541
Drug	DEAC	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6	1.02e-05	55	56	4	CID000007277
Drug	Les T	HARS2 CAPN2 CAPN6 HARS1 DMPK	1.30e-05	123	56	5	CID000003189
Drug	Kemptide	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 PRKCD	1.35e-05	124	56	5	CID000100074
Drug	I-Q-S	RPS6KA3 LAMA5 PRKCD DMPK TNR	4.08e-05	156	56	5	CID000003540
Drug	2-[(1R,2R,3S,4R,5R,6S)-2-[(2R,5S)-3-[(3S,4S,5R,6S)-4,5-dihydroxy-3-(methylamino)-6-methylol-tetrahydropyran-2-yl]-4-formyl-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine	HARS2 LAMA5 HARS1 F8	5.22e-05	83	56	4	CID011968896
Drug	AC1L1GZB	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 LTA4H	5.64e-05	167	56	5	CID000003908
Disease	Coffin-Lowry syndrome (implicated_via_orthology)	RPS6KA2 RPS6KA3 RPS6KA6	2.45e-08	4	55	3	DOID:3783 (implicated_via_orthology)
Disease	Dyggve-Melchior-Clausen disease (implicated_via_orthology)	RAB10 RAB8B RAB8A	2.45e-08	4	55	3	DOID:0111167 (implicated_via_orthology)
Disease	Smith-McCort dysplasia (implicated_via_orthology)	RAB10 RAB8B RAB8A	6.11e-08	5	55	3	DOID:0060247 (implicated_via_orthology)
Disease	Usher syndrome type 3B (implicated_via_orthology)	HARS2 HARS1	3.41e-06	2	55	2	DOID:0110842 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease, axonal type 2W (implicated_via_orthology)	HARS2 HARS1	3.41e-06	2	55	2	DOID:0110162 (implicated_via_orthology)
Disease	Perrault syndrome (implicated_via_orthology)	HARS2 HARS1	2.04e-05	4	55	2	DOID:0050857 (implicated_via_orthology)
Disease	sensory peripheral neuropathy (implicated_via_orthology)	HARS2 HARS1	2.04e-05	4	55	2	DOID:2491 (implicated_via_orthology)
Disease	Myocardial Ischemia	TXNRD1 SLC8A1 RAB1B HMGCS2	3.29e-04	176	55	4	C0151744
Disease	lysophosphatidylethanolamine 18:0 measurement	KBTBD3 TNR	3.53e-04	15	55	2	EFO_0010367
Disease	Common Variable Immunodeficiency	PRKCD CD81	3.53e-04	15	55	2	C0009447
Disease	Disorder of eye	KLHL7 HARS1 RS1 BBS12	6.63e-04	212	55	4	C0015397
Disease	blood pressure	SLC9A9 TNR	7.69e-04	22	55	2	EFO_0004325
Disease	stroke outcome severity measurement	RPS6KA2 TNR NAALADL2	1.27e-03	114	55	3	EFO_0009603

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDGIATGYLVLKELG	DNMT3B	581	Q9UBC3
LKNDLGVGYLLIGDN	ASPH	456	Q12797
LYYALKEEKVFLGGG	BBS12	526	Q6ZW61
DLFSGKLYLIGIAAI	CD81	196	P60033
YLLYDDKGVGLGEAL	RBM12B	431	Q8IXT5
YDLLFKLLLIGDSGV	RAB10	6	P61026
DYLFKLLLIGDSGVG	RAB1B	6	Q9H0U4
DYLFKLLLIGDSGVG	RAB8A	6	P61006
EYLALIFEKGGSYLG	QSOX1	186	O00391
DYLFKLLLIGDSGVG	RAB8B	6	Q92930
AIGIEDKIYILGGDY	KBTBD3	546	Q8NAB2
KGFALLFYLEQLLGG	LTA4H	386	P09960
YKFGLEGIAAVLLGS	CYP27B1	191	O15528
LGSYGLKDGDIVVLL	DDI1	61	Q8WTU0
YGGLAFLSLEALEGL	LRRC55	171	Q6ZSA7
DEFLLLLDKGVYGLL	MALT1	396	Q9UDY8
GKVLLGELKGRGEYF	PRKCD	361	Q05655
EFLGGEVLLYKLDDL	MYO19	26	Q96H55
GKLYLILDFLRGGDL	RPS6KA3	141	P51812
LYKGLEAFGGLKLED	HMGCS2	331	P54868
LLYGEVGDTLLIIFK	F8	471	P00451
GLGGLDNVEYYDIKL	KLHL7	491	Q8IXQ5
LLKVLGTGAYGKVFL	RPS6KA5	51	O75582
GKLYLILDFLRGGDV	RPS6KA6	146	Q9UK32
SLYGQLAGLKELGLL	PLA2G4B	311	P0C869
GSLVLLYDFGAGLKK	LAMA5	2996	O15230
GVLSIYYLGKKFLGD	MPND	91	Q8N594
GFYDSGLLQGKLALL	NQO2	131	P16083
YVGGDLLTLLSKFGE	DMPK	151	Q09013
IGFYLLLKGLGVDLL	G6PC1	221	P35575
DGLDYLALGKFFKGL	DNAH7	1356	Q8WXX0
LFLKGTYGDGYRLTL	ABCA2	1206	Q9BZC7
YLLKLLEGIGLENLD	DNAJC13	2136	O75165
SDGSGKLGLKEFYIL	CAPN2	586	P17655
AYAKLLGCYEALDGL	CAPN6	166	Q9Y6Q1
LKGLVALGGIYLLFI	SLC39A10	496	Q9ULF5
LEGLGDLKLLFEYLT	HARS1	296	P12081
LLKYFTSDGLPIGDL	MTBP	606	Q96DY7
ALEGLGDLKLLFEYL	HARS2	296	P49590
GDLKLLFEYLTLFGI	HARS2	301	P49590
LGLGGYELKLEQTLG	SLC9A9	626	Q8IVB4
LIYKIELAGGLGAIF	IL1RAPL2	351	Q9NP60
LGGKGFLVIGYLLEK	NBEA	546	Q8NFP9
FSLDKIYLIGGDLGP	GINS2	21	Q9Y248
GGLYDFLTKLVHLGQ	TENM1	2361	Q9UKZ4
YYVGGDLLTLLSKFE	CDC42BPA	156	Q5VT25
GFLLYELGDTGKLVA	TMX3	236	Q96JJ7
DLPKSYDYDLIIIGG	TXNRD1	156	Q16881
VDFILLKYGLVGGEG	TNR	531	Q92752
GYKIFSGLLKVAGLL	STAB1	1736	Q9NY15
KLEHLALIYFGGLSG	UBIAD1	156	Q9Y5Z9
EAGEFLPKGYLALGL	TTC7A	481	Q9ULT0
AYAGLLGTIELKLDL	PIGO	496	Q8TEQ8
EGFLLLLLFGYEATL	RS1	6	O15537
EGKLYLILDFLRGGD	RPS6KA2	131	Q15349
LLNELGGFTITGKYL	SLC8A1	641	P32418
SLEKAGFGGVLLYID	NAALADL2	316	Q58DX5