Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H4K8 acetyltransferase activity

BRPF3 BRPF1

2.89e-0511152GO:0043996
GeneOntologyMolecularFunctionhistone H4K5 acetyltransferase activity

BRPF3 BRPF1

2.89e-0511152GO:0043995
GeneOntologyMolecularFunctionhistone H4K12 acetyltransferase activity

BRPF3 BRPF1

3.46e-0512152GO:0043997
GeneOntologyMolecularFunctionhistone H4 acetyltransferase activity

BRPF3 BRPF1

1.32e-0423152GO:0010485
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

UBE2Q1 ATG3

4.67e-0443152GO:0061650
GeneOntologyMolecularFunctionhistone acetyltransferase activity

BRPF3 BRPF1

6.57e-0451152GO:0004402
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

BRPF3 BRPF1

7.64e-0455152GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

BRPF3 BRPF1

9.09e-0460152GO:0034212
GeneOntologyMolecularFunctionhistone binding

BPTF SUPT6H SPTY2D1

9.34e-04265153GO:0042393
GeneOntologyMolecularFunctionN-acetyltransferase activity

BRPF3 BRPF1

1.53e-0378152GO:0008080
GeneOntologyMolecularFunctionacyltransferase activity

UBE2Q1 ATG3 BRPF3 BRPF1

2.18e-03775154GO:0016746
GeneOntologyMolecularFunctionN-acyltransferase activity

BRPF3 BRPF1

2.60e-03102152GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

BRPF3 BRPF1

2.70e-03104152GO:0016407
GeneOntologyMolecularFunctionhistone modifying activity

BRPF3 BRPF1

1.25e-02229152GO:0140993
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

BRPF3 BRPF1

1.34e-02238152GO:0016747
GeneOntologyBiologicalProcessprotein-DNA complex organization

BPTF SUPT6H SPTY2D1 BRPF3 BRPF1 BRF1

4.36e-05999156GO:0071824
GeneOntologyBiologicalProcesschromatin remodeling

BPTF SUPT6H SPTY2D1 BRPF3 BRPF1

1.31e-04741155GO:0006338
GeneOntologyBiologicalProcesschromatin organization

BPTF SUPT6H SPTY2D1 BRPF3 BRPF1

3.19e-04896155GO:0006325
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

BRPF3 BRPF1

1.01e-057152GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

BRPF3 BRPF1

1.34e-058152GO:0070775
GeneOntologyCellularComponentphagophore assembly site

ATG3 VMP1

3.51e-0439152GO:0000407
GeneOntologyCellularComponenthistone acetyltransferase complex

BRPF3 BRPF1

2.02e-0394152GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

BRPF3 BRPF1

2.47e-03104152GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

BRPF3 BRPF1

2.71e-03109152GO:1902493
GeneOntologyCellularComponentfilopodium

UBE2Q1 TUBB3

3.43e-03123152GO:0030175
GeneOntologyCellularComponenttransferase complex

ATG3 ANAPC15 BRPF3 BRPF1

4.06e-03963154GO:1990234
GeneOntologyCellularComponentintracellular protein-containing complex

ATG3 ANAPC15 BRPF3 BRPF1

4.20e-03972154GO:0140535
DomainBromodomain_CS

BPTF BRPF3 BRPF1

1.33e-0626163IPR018359
DomainBROMODOMAIN_1

BPTF BRPF3 BRPF1

3.94e-0637163PS00633
DomainBromodomain

BPTF BRPF3 BRPF1

4.27e-0638163PF00439
DomainBROMODOMAIN_2

BPTF BRPF3 BRPF1

5.39e-0641163PS50014
DomainBROMO

BPTF BRPF3 BRPF1

5.80e-0642163SM00297
DomainBromodomain

BPTF BRPF3 BRPF1

5.80e-0642163IPR001487
Domain-

BPTF BRPF3 BRPF1

5.80e-06421631.20.920.10
DomainEnhancer_polycomb-like_N

BRPF3 BRPF1

1.92e-058162IPR019542
DomainEPL1

BRPF3 BRPF1

1.92e-058162PF10513
DomainZinc_finger_PHD-type_CS

BPTF BRPF3 BRPF1

2.18e-0565163IPR019786
DomainZnf_PHD-finger

BPTF BRPF3 BRPF1

3.92e-0579163IPR019787
DomainPHD

BPTF BRPF3 BRPF1

5.60e-0589163SM00249
DomainZnf_PHD

BPTF BRPF3 BRPF1

5.98e-0591163IPR001965
DomainZF_PHD_2

BPTF BRPF3 BRPF1

6.80e-0595163PS50016
DomainZF_PHD_1

BPTF BRPF3 BRPF1

7.02e-0596163PS01359
DomainPWWP

BRPF3 BRPF1

1.30e-0420162SM00293
DomainEPHD

BRPF3 BRPF1

1.57e-0422162PS51805
DomainPWWP

BRPF3 BRPF1

1.72e-0423162PF00855
DomainPWWP_dom

BRPF3 BRPF1

1.72e-0423162IPR000313
DomainPWWP

BRPF3 BRPF1

1.88e-0424162PS50812
DomainZnf_FYVE_PHD

BPTF BRPF3 BRPF1

2.48e-04147163IPR011011
DomainPHD

BPTF BRPF3

1.84e-0375162PF00628
Domain-

BPTF BRPF3 BRPF1

6.12e-034491633.30.40.10
DomainZnf_RING/FYVE/PHD

BPTF BRPF3 BRPF1

6.51e-03459163IPR013083
PathwayWP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH

ATG3 VMP1

1.66e-0423122M39325
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

BRPF3 BRPF1

2.66e-0429122MM15340
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

BRPF3 BRPF1

2.85e-0430122M27637
PathwayREACTOME_HATS_ACETYLATE_HISTONES

BRPF3 BRPF1

6.73e-0446122MM14935
Pubmed

The chromatin regulator Brpf1 regulates embryo development and cell proliferation.

TUBB3 BRPF3 BRPF1

7.81e-074016325773539
Pubmed

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.

BRPF3 BRPF1

1.19e-06416226677226
Pubmed

Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points.

MNX1 TUBB3

2.97e-06616212575949
Pubmed

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

BRPF3 BRPF1

4.16e-06716218794358
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

BPTF ZC3H4 SUPT6H SPTY2D1

4.50e-0625116431076518
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

BPTF BRPF3 BRPF1

5.29e-067516325593309
Pubmed

Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner.

MNX1 TUBB3

5.55e-06816221709239
Pubmed

Species-specific pace of development is associated with differences in protein stability.

MNX1 TUBB3

7.13e-06916232943498
Pubmed

Regulation of motor neuron specification by phosphorylation of neurogenin 2.

MNX1 TUBB3

8.91e-061016218400164
Pubmed

Slit/Robo signals prevent spinal motor neuron emigration by organizing the spinal cord basement membrane.

MNX1 TUBB3

8.91e-061016231356769
Pubmed

p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding.

ATG3 VMP1

8.91e-061016221220506
Pubmed

The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice.

MNX1 TUBB3

1.09e-051116231754024
Pubmed

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.

TUBB3 SPRYD3

1.31e-051216229293652
Pubmed

Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis.

MNX1 TUBB3

1.80e-051416219797899
Pubmed

Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction.

MNX1 TUBB3

1.80e-051416225530182
Pubmed

The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.

TUBB3 BRPF1

1.80e-051416225757017
Pubmed

Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.

MNX1 TUBB3

2.37e-051616219800948
Pubmed

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.

MNX1 TUBB3

2.37e-051616210217145
Pubmed

TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation.

MNX1 TUBB3

2.37e-051616231995756
Pubmed

Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.

MNX1 TUBB3

2.37e-051616230661738
Pubmed

Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation.

MNX1 TUBB3

2.69e-051716222318233
Pubmed

Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons.

MNX1 TUBB3

2.69e-051716218065432
Pubmed

Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.

MNX1 TUBB3

2.69e-051716212954718
Pubmed

Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal.

MNX1 TUBB3

3.38e-051916231461644
Pubmed

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.

MNX1 TUBB3

3.38e-051916211567614
Pubmed

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.

MNX1 TUBB3

4.15e-052116219542360
Pubmed

Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.

MNX1 TUBB3

4.15e-052116236240771
Pubmed

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

BRPF3 BRPF1

4.15e-052116227270040
Pubmed

A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons.

MNX1 TUBB3

4.15e-052116216129397
Pubmed

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation.

MNX1 TUBB3

4.56e-05221628565076
Pubmed

Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system.

MNX1 TUBB3

4.99e-052316219806666
Pubmed

Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.

MNX1 TUBB3

5.44e-052416217537790
Pubmed

Directed differentiation of telencephalic precursors from embryonic stem cells.

MNX1 TUBB3

5.92e-052516215696161
Pubmed

Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.

MNX1 TUBB3

5.92e-052516219389377
Pubmed

Motor innervation directs the correct development of the mouse sympathetic nervous system.

MNX1 TUBB3

5.92e-052516239152112
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

TSR1 BPTF ZC3H4 SUPT6H SPTY2D1

6.19e-0598916536424410
Pubmed

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.

MNX1 TUBB3

6.41e-052616228684471
Pubmed

Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.

MNX1 TUBB3

6.92e-052716225843547
Pubmed

Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains.

MNX1 TUBB3

8.00e-052916230177510
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TSR1 ZC3H4 SUPT6H BRPF3

8.33e-0552916414621295
Pubmed

Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression.

MNX1 TUBB3

8.57e-053016234974536
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

TSR1 BPTF ZC3H4 TUBB3 SUPT6H

9.47e-05108216538697112
Pubmed

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.

MNX1 TUBB3

9.76e-053216219286674
Pubmed

The transcriptional control of trunk neural crest induction, survival, and delamination.

MNX1 TUBB3

1.10e-043416215691760
Pubmed

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.

MNX1 TUBB3

1.10e-043416218590716
Pubmed

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

BRPF3 BRPF1

1.69e-044216216387653
Pubmed

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.

ZC3H4 SUPT6H

1.77e-044316234672947
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

ATG3 TSR1 ZC3H4 SUPT6H

1.87e-0465316433742100
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

MNX1 BPTF ZC3H4

2.76e-0428316330585729
Pubmed

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.

BRPF3 BRPF1

3.57e-046116232911434
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

VMP1 ZC3H4 BRPF1

4.40e-0433216337433992
Pubmed

Tagging genes with cassette-exchange sites.

TSR1 BPTF BRF1

4.52e-0433516315741177
InteractionH2BC21 interactions

ATG3 BPTF ZC3H4 SUPT6H BRPF3 BRPF1

9.89e-06696166int:H2BC21
InteractionZNF330 interactions

TSR1 SUPT6H SPTY2D1 CHIC2 BRPF1

1.85e-05446165int:ZNF330
InteractionCOIL interactions

MNX1 TUBB3 SUPT6H SPTY2D1 BRPF1

5.15e-05552165int:COIL
InteractionH3-3B interactions

BPTF SUPT6H SPTY2D1

9.36e-05114163int:H3-3B
InteractionCLEC4C interactions

TUBB3 BRF1

1.35e-0422162int:CLEC4C
InteractionTOP1 interactions

TSR1 ZC3H4 SUPT6H SPTY2D1 BRPF1

1.54e-04696165int:TOP1
InteractionCSNK2A2 interactions

TSR1 ZC3H4 BRPF3 BRPF1 BRF1

1.78e-04718165int:CSNK2A2
InteractionH3C8 interactions

SUPT6H SPTY2D1

2.05e-0427162int:H3C8
InteractionLRRFIP1 interactions

VMP1 TSR1 BRF1

2.23e-04153163int:LRRFIP1
InteractionNFE2L2 interactions

BPTF BRPF3 BRPF1

2.50e-04159163int:NFE2L2
GeneFamilyPHD finger proteins

BPTF BRPF3 BRPF1

1.91e-059011388
GeneFamilyPWWP domain containing

BRPF3 BRPF1

7.72e-05221121147
CoexpressionGSE37416_CTRL_VS_3H_F_TULARENSIS_LVS_NEUTROPHIL_DN

MNX1 SUPT6H SPTY2D1 BRPF3

5.04e-06195164M5330
CoexpressionGSE9960_HEALTHY_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_UP

MNX1 BRPF1 BRF1

1.87e-04187163M7123
CoexpressionGSE11864_CSF1_VS_CSF1_IFNG_PAM3CYS_IN_MAC_DN

ATG3 TSR1 SPRYD3

2.21e-04198163M3140
CoexpressionGSE12366_GC_VS_NAIVE_BCELL_UP

TUBB3 CHIC2 ANAPC15

2.21e-04198163M3168
CoexpressionGSE45365_NK_CELL_VS_BCELL_UP

TSR1 SPTY2D1 CHIC2

2.21e-04198163M10031
CoexpressionGSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP

ZC3H4 SUPT6H BRF1

2.24e-04199163M7254
CoexpressionGSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_CORTICOSTERONE_TREATED_DN

ATG3 TSR1 SUPT6H

2.28e-04200163M7748
CoexpressionANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_6HR_UP

ATG3 SPTY2D1

2.30e-0437162M41003
CoexpressionLINSLEY_MIR16_TARGETS

UBE2Q1 TSR1 SPRYD3

2.48e-04206163M2284
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

ATG3 VMP1 BPTF CHIC2

6.61e-07200164e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

VMP1 BPTF SPTY2D1

4.37e-051961637bced0cc2112697593c478fa291b8ed3941fb811
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

VMP1 BPTF

7.48e-045092GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Diseasemetabolic syndrome

BPTF ZC3H4

4.53e-03200152EFO_0000195
Diseasenon-high density lipoprotein cholesterol measurement

BPTF ZC3H4 SPTY2D1

5.15e-03713153EFO_0005689

Protein segments in the cluster

PeptideGeneStartEntry
KPASEHYDDEEEEDD

ANAPC15

56

P60006
EDLDAEVEYDMDEED

BRPF3

146

Q9ULD4
YDDHESEEEEEEEDM

BPTF

126

Q12830
MEEDDDDSDYPEEME

BPTF

166

Q12830
DDSDYPEEMEDDDDD

BPTF

171

Q12830
EEDEDEGEAADMEEY

ATG3

146

Q9NT62
PEEDEDEDDEDHFPY

MNX1

356

P50219
MADFDEIYEEEEDEE

CHIC2

1

Q9UKJ5
DDDDDEYDSEMEDFI

SPTY2D1

591

Q68D10
AEELDEEVEYDMDEE

BRPF1

206

P55201
DDEDDDEEEYGKEEH

SUPT6H

126

Q7KZ85
MYLHQEGEEEEEEEE

SPRYD3

366

Q8NCJ5
GDEYEYDDMEHEDFM

TSR1

416

Q2NL82
EEEGEMYEDDEEESE

TUBB3

431

Q13509
YHADEEADEEEPDEE

BRF1

636

Q92994
DHPEDEEDFYEEEMD

ZC3H4

276

Q9UPT8
DEEMPEDTEDLDHYE

UBE2Q1

191

Q7Z7E8
DEEYQEFEEMLEHAE

VMP1

221

Q96GC9