Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	2.79e-08	465	78	13	GO:0046873
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 SLC45A1 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	1.26e-07	627	78	14	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 SLC45A1 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	2.53e-07	664	78	14	GO:0008324
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 SLC45A1 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	1.23e-06	758	78	14	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 SLC45A1 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	2.09e-06	793	78	14	GO:0015075
GeneOntologyMolecularFunction	transmembrane transporter activity	ATP13A1 KCNV2 KCNG4 SLC22A23 SCN4A SCN9A NIPAL2 SLC6A15 SLC45A1 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	4.44e-05	1180	78	15	GO:0022857
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNV2 KCNG4 SCN4A SCN9A PKDREJ MCOLN1 KCNK4 RYR3	5.76e-05	343	78	8	GO:0005261
GeneOntologyMolecularFunction	transporter activity	ATP13A1 KCNV2 KCNG4 SLC22A23 SCN4A SCN9A NIPAL2 SLC6A15 SLC45A1 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	1.20e-04	1289	78	15	GO:0005215
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3CA PIK3CB	3.12e-04	7	78	2	GO:0035005
GeneOntologyMolecularFunction	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CA PIK3CB	3.12e-04	7	78	2	GO:0046934
GeneOntologyMolecularFunction	dolichyl-phosphate-mannose-protein mannosyltransferase activity	TMTC1 TMTC4	4.15e-04	8	78	2	GO:0004169
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNV2 KCNG4 SCN4A SCN9A PKDREJ MCOLN1 KCNK4 RYR3	4.21e-04	459	78	8	GO:0005216
GeneOntologyMolecularFunction	lipid kinase activity	PIK3CA PIK3CB DGKG	5.49e-04	41	78	3	GO:0001727
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	ATP13A1 MCOLN1 SLC30A6	6.77e-04	44	78	3	GO:0046915
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3CA PIK3CB	8.10e-04	11	78	2	GO:0016303
GeneOntologyMolecularFunction	channel activity	KCNV2 KCNG4 SCN4A SCN9A PKDREJ MCOLN1 KCNK4 RYR3	1.01e-03	525	78	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNV2 KCNG4 SCN4A SCN9A PKDREJ MCOLN1 KCNK4 RYR3	1.02e-03	526	78	8	GO:0022803
GeneOntologyMolecularFunction	sodium channel activity	SCN4A SCN9A MCOLN1	1.10e-03	52	78	3	GO:0005272
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	CYFIP1 CYFIP2	1.33e-03	14	78	2	GO:0000340
GeneOntologyMolecularFunction	ubiquitin-ubiquitin ligase activity	UBE4A UBE4B	1.33e-03	14	78	2	GO:0034450
GeneOntologyMolecularFunction	insulin receptor substrate binding	PIK3CA PIK3CB	1.53e-03	15	78	2	GO:0043560
GeneOntologyMolecularFunction	potassium channel activity	KCNV2 KCNG4 MCOLN1 KCNK4	1.59e-03	128	78	4	GO:0005267
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	MCOLN1 RYR3	2.21e-03	18	78	2	GO:0015278
GeneOntologyMolecularFunction	GTPase binding	TBC1D13 CYFIP1 DAAM2 DAAM1 GNB3 CYFIP2	2.84e-03	360	78	6	GO:0051020
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	PKDREJ MCOLN1 ATP2B1 RYR3	2.91e-03	151	78	4	GO:0015085
GeneOntologyMolecularFunction	RNA cap binding	CYFIP1 CYFIP2	3.01e-03	21	78	2	GO:0000339
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNV2 KCNG4 MCOLN1 KCNK4	4.16e-03	167	78	4	GO:0015079
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN4A SCN9A SLC6A15 MCOLN1	4.53e-03	171	78	4	GO:0015081
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3CA PIK3CB	4.61e-03	26	78	2	GO:0052742
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A SCN9A	4.61e-03	26	78	2	GO:0005248
GeneOntologyBiologicalProcess	metal ion transport	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 LILRA5 KCNK4 RYR3 SLC30A6	2.37e-05	1000	79	14	GO:0030001
GeneOntologyBiologicalProcess	regulation of neurotrophin TRK receptor signaling pathway	CYFIP1 ZDHHC17 CYFIP2	3.54e-05	17	79	3	GO:0051386
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	4.47e-05	922	79	13	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	5.56e-05	942	79	13	GO:0098655
GeneOntologyBiologicalProcess	calcium ion export	MCOLN1 ATP2B1	8.65e-05	4	79	2	GO:1901660
GeneOntologyBiologicalProcess	monoatomic cation transport	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 LILRA5 KCNK4 RYR3 SLC30A6	1.14e-04	1157	79	14	GO:0006812
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	ATP13A1 KCNV2 KCNG4 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 KCNK4 RYR3 SLC30A6	1.21e-04	1017	79	13	GO:0098660
GeneOntologyBiologicalProcess	monoatomic ion transport	ATP13A1 KCNV2 KCNG4 SLC22A23 SCN4A SCN9A NIPAL2 SLC6A15 PKDREJ MCOLN1 ATP2B1 LILRA5 KCNK4 RYR3 SLC30A6	1.97e-04	1374	79	15	GO:0006811
GeneOntologyCellularComponent	cation channel complex	KCNV2 KCNG4 SCN4A SCN9A KCNK4 RYR3	2.65e-04	235	79	6	GO:0034703
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class I	PIK3CA PIK3CB	4.99e-04	9	79	2	GO:0097651
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class IA	PIK3CA PIK3CB	4.99e-04	9	79	2	GO:0005943
Domain	Ion_trans_dom	KCNV2 KCNG4 SCN4A SCN9A MCOLN1 RYR3	8.76e-06	114	79	6	IPR005821
Domain	Ion_trans	KCNV2 KCNG4 SCN4A SCN9A MCOLN1 RYR3	8.76e-06	114	79	6	PF00520
Domain	Ufd2P_core	UBE4A UBE4B	1.77e-05	2	79	2	PF10408
Domain	Cytoplasmic_FMR1-int	CYFIP1 CYFIP2	1.77e-05	2	79	2	IPR008081
Domain	Ub_conjug_fac_E4_core	UBE4A UBE4B	1.77e-05	2	79	2	IPR019474
Domain	FragX_IP	CYFIP1 CYFIP2	1.77e-05	2	79	2	PF05994
Domain	PI3K_p85B	PIK3CA PIK3CB	5.29e-05	3	79	2	PF02192
Domain	PI3K_p85B	PIK3CA PIK3CB	5.29e-05	3	79	2	SM00143
Domain	Channel_four-helix_dom	KCNV2 KCNG4 SCN4A SCN9A	9.88e-05	57	79	4	IPR027359
Domain	-	KCNV2 KCNG4 SCN4A SCN9A	9.88e-05	57	79	4	1.20.120.350
Domain	DUF1394	CYFIP1 CYFIP2	1.05e-04	4	79	2	PF07159
Domain	DUF1736	TMTC1 TMTC4	1.05e-04	4	79	2	IPR013618
Domain	PI3K_ABD	PIK3CA PIK3CB	1.05e-04	4	79	2	PS51544
Domain	DUF1394	CYFIP1 CYFIP2	1.05e-04	4	79	2	IPR009828
Domain	PI3K_adapt-bd_dom	PIK3CA PIK3CB	1.05e-04	4	79	2	IPR003113
Domain	DUF1736	TMTC1 TMTC4	1.05e-04	4	79	2	PF08409
Domain	K_chnl_volt-dep_Kv9	KCNV2 KCNG4	3.66e-04	7	79	2	IPR003971
Domain	PI3K_Ras-bd_dom	PIK3CA PIK3CB	3.66e-04	7	79	2	IPR000341
Domain	PI3K_rbd	PIK3CA PIK3CB	3.66e-04	7	79	2	PF00794
Domain	U_BOX	UBE4A UBE4B	3.66e-04	7	79	2	PS51698
Domain	PI3K_RBD	PIK3CA PIK3CB	3.66e-04	7	79	2	PS51546
Domain	PI3K_rbd	PIK3CA PIK3CB	3.66e-04	7	79	2	SM00144
Domain	PI3K_C2_dom	PIK3CA PIK3CB	4.87e-04	8	79	2	IPR002420
Domain	DAD_dom	DAAM2 DAAM1	4.87e-04	8	79	2	IPR014767
Domain	Ubox	UBE4A UBE4B	4.87e-04	8	79	2	SM00504
Domain	PI3K_C2	PIK3CA PIK3CB	4.87e-04	8	79	2	PF00792
Domain	U-box	UBE4A UBE4B	4.87e-04	8	79	2	PF04564
Domain	DAD	DAAM2 DAAM1	4.87e-04	8	79	2	PS51231
Domain	PI3K_C2	PIK3CA PIK3CB	4.87e-04	8	79	2	PS51547
Domain	PI3K_C2	PIK3CA PIK3CB	4.87e-04	8	79	2	SM00142
Domain	PI3Ka	PIK3CA PIK3CB	6.24e-04	9	79	2	PF00613
Domain	Drf_GBD	DAAM2 DAAM1	6.24e-04	9	79	2	PF06371
Domain	FH3_dom	DAAM2 DAAM1	6.24e-04	9	79	2	IPR010472
Domain	GTPase-bd	DAAM2 DAAM1	6.24e-04	9	79	2	IPR010473
Domain	Drf_FH3	DAAM2 DAAM1	6.24e-04	9	79	2	PF06367
Domain	-	PIK3CA PIK3CB	6.24e-04	9	79	2	1.25.40.70
Domain	Drf_FH3	DAAM2 DAAM1	6.24e-04	9	79	2	SM01139
Domain	Drf_GBD	DAAM2 DAAM1	6.24e-04	9	79	2	SM01140
Domain	PI3Ka	PIK3CA PIK3CB	6.24e-04	9	79	2	SM00145
Domain	Na_channel_asu	SCN4A SCN9A	7.78e-04	10	79	2	IPR001696
Domain	Ubox_domain	UBE4A UBE4B	7.78e-04	10	79	2	IPR003613
Domain	Na_trans_assoc	SCN4A SCN9A	7.78e-04	10	79	2	IPR010526
Domain	PIK_HELICAL	PIK3CA PIK3CB	7.78e-04	10	79	2	PS51545
Domain	PI_Kinase	PIK3CA PIK3CB	7.78e-04	10	79	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3CA PIK3CB	7.78e-04	10	79	2	IPR001263
Domain	Na_trans_assoc	SCN4A SCN9A	7.78e-04	10	79	2	PF06512
Domain	GBD/FH3_dom	DAAM2 DAAM1	9.48e-04	11	79	2	IPR014768
Domain	PKD_channel	PKDREJ MCOLN1	9.48e-04	11	79	2	PF08016
Domain	GBD_FH3	DAAM2 DAAM1	9.48e-04	11	79	2	PS51232
Domain	PKD1_2_channel	PKDREJ MCOLN1	9.48e-04	11	79	2	IPR013122
Domain	EF-hand-dom_pair	CAPN9 SCN9A DGKG MACF1 STAT4 RYR3	1.36e-03	287	79	6	IPR011992
Domain	FH2	DAAM2 DAAM1	1.79e-03	15	79	2	PS51444
Domain	PI3/4_kinase_CS	PIK3CA PIK3CB	1.79e-03	15	79	2	IPR018936
Domain	FH2_Formin	DAAM2 DAAM1	1.79e-03	15	79	2	IPR015425
Domain	FH2	DAAM2 DAAM1	1.79e-03	15	79	2	PF02181
Domain	FH2	DAAM2 DAAM1	1.79e-03	15	79	2	SM00498
Domain	-	PIK3CA PIK3CB	2.04e-03	16	79	2	1.10.1070.11
Domain	PI3Kc	PIK3CA PIK3CB	2.04e-03	16	79	2	SM00146
Domain	Znf_RING-CH	RNF167 RNF145	2.31e-03	17	79	2	IPR011016
Domain	RINGv	RNF167 RNF145	2.31e-03	17	79	2	SM00744
Domain	PI3/4_kinase_cat_dom	PIK3CA PIK3CB	2.59e-03	18	79	2	IPR000403
Domain	PI3_PI4_kinase	PIK3CA PIK3CB	2.59e-03	18	79	2	PF00454
Domain	PI3_4_KINASE_3	PIK3CA PIK3CB	2.59e-03	18	79	2	PS50290
Domain	PI3_4_KINASE_1	PIK3CA PIK3CB	2.59e-03	18	79	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CA PIK3CB	2.59e-03	18	79	2	PS00916
Domain	ARM-type_fold	PIK3CA PIK3CB DAAM2 BTAF1 DAAM1 RYR3	3.13e-03	339	79	6	IPR016024
Domain	EF-hand_1	CAPN9 DGKG MACF1 RYR3	3.95e-03	152	79	4	PF00036
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY	CYFIP1 PIK3CA PIK3CB CYFIP2	6.08e-06	29	59	4	M47717
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY	CYFIP1 PIK3CA PIK3CB CYFIP2	6.99e-06	30	59	4	M47738
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP2A_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.71e-04	5	59	2	M48997
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.71e-04	5	59	2	M49020
Pathway	REACTOME_CARDIAC_CONDUCTION	SCN4A SCN9A ATP2B1 KCNK4 RYR3	2.07e-04	130	59	5	M27454
Pathway	WP_CANCER_PATHWAYS	IL12RB1 HEYL FZD3 PIK3CA PIK3CB GNB3 ADCY9 STAT4 BID	2.37e-04	507	59	9	M48302
Pathway	KEGG_MEDICUS_REFERENCE_CCR2_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CA PIK3CB GNB3	2.88e-04	31	59	3	M47540
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CA PIK3CB GNB3	2.88e-04	31	59	3	M47541
Pathway	REACTOME_SIGNALING_BY_LTK_IN_CANCER	PIK3CA PIK3CB	3.57e-04	7	59	2	M48255
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	3.57e-04	7	59	2	M47790
Pathway	KEGG_JAK_STAT_SIGNALING_PATHWAY	IL12RB1 PIK3CA PIK3CB STAT4 IFNL3	4.67e-04	155	59	5	M17411
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47399
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47395
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47404
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47405
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47803
Pathway	KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47482
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47498
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	4.74e-04	8	59	2	M47715
Pathway	REACTOME_PI3K_AKT_ACTIVATION	PIK3CA PIK3CB	4.74e-04	8	59	2	MM14776
Pathway	PID_IL23_PATHWAY	IL12RB1 PIK3CA STAT4	4.89e-04	37	59	3	M196
Pathway	PID_FAS_PATHWAY	PIK3CA PIK3CB BID	5.29e-04	38	59	3	M94
Pathway	WP_G13_SIGNALING	CYFIP1 PIK3CA PIK3CB	5.29e-04	38	59	3	M39606
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47397
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47392
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47391
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47402
Pathway	KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47802
Pathway	REACTOME_INTERLEUKIN_23_SIGNALING	IL12RB1 STAT4	6.08e-04	9	59	2	M27896
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	6.08e-04	9	59	2	M47481
Pathway	REACTOME_PI3K_AKT_ACTIVATION	PIK3CA PIK3CB	6.08e-04	9	59	2	M714
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNV2 KCNG4 GNB3 KCNK4	7.46e-04	98	59	4	MM14545
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	7.58e-04	10	59	2	M47400
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	7.58e-04	10	59	2	M47401
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	7.58e-04	10	59	2	M47615
Pathway	KEGG_MEDICUS_REFERENCE_IL12_23_TO_JAK_STAT_SIGNALING_PATHWAY	IL12RB1 STAT4	7.58e-04	10	59	2	M47907
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	PIK3CA PIK3CB STAT4	8.16e-04	44	59	3	M1012
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNV2 KCNG4 GNB3 KCNK4	8.99e-04	103	59	4	M1073
Pathway	REACTOME_SIGNALING_BY_VEGF	CYFIP1 PIK3CA PIK3CB CYFIP2	8.99e-04	103	59	4	MM14752
Pathway	REACTOME_SIGNALING_BY_LTK	PIK3CA PIK3CB	9.24e-04	11	59	2	MM17235
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47797
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47403
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47406
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47756
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	PIK3CA PIK3CB	9.24e-04	11	59	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	9.24e-04	11	59	2	M47501
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	SCN9A TAS1R1 GNB3	9.91e-04	47	59	3	M42524
Pathway	REACTOME_SIGNALING_BY_VEGF	CYFIP1 PIK3CA PIK3CB CYFIP2	1.00e-03	106	59	4	M27077
Pathway	REACTOME_SIGNALING_BY_LTK	PIK3CA PIK3CB	1.11e-03	12	59	2	M48256
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.11e-03	12	59	2	M47393
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350	PIK3CA PIK3CB	1.11e-03	12	59	2	M47798
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.11e-03	12	59	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.11e-03	12	59	2	M47559
Pathway	REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS	PIK3CA PIK3CB	1.11e-03	12	59	2	M29851
Pathway	WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION	PIK3CA PIK3CB	1.11e-03	12	59	2	M45559
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	PIK3CA PIK3CB	1.11e-03	12	59	2	M27905
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	PIK3CA PIK3CB	1.11e-03	12	59	2	MM15623
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.30e-03	13	59	2	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.30e-03	13	59	2	M47603
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	CYFIP1 PIK3CA PIK3CB CYFIP2	1.31e-03	114	59	4	MM14814
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.52e-03	14	59	2	M47390
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE	PIK3CA PIK3CB	1.52e-03	14	59	2	M39840
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.52e-03	14	59	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.52e-03	14	59	2	M47536
Pathway	REACTOME_MUSCLE_CONTRACTION	SCN4A SCN9A ATP2B1 KCNK4 RYR3	1.57e-03	203	59	5	M5485
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.75e-03	15	59	2	M47389
Pathway	BIOCARTA_NO2IL12_PATHWAY	IL12RB1 STAT4	1.75e-03	15	59	2	M6231
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.75e-03	15	59	2	M47663
Pathway	BIOCARTA_NO2IL12_PATHWAY	IL12RB1 STAT4	1.75e-03	15	59	2	MM1446
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA PIK3CB	1.75e-03	15	59	2	M47475
Pathway	REACTOME_TIE2_SIGNALING	PIK3CA PIK3CB	2.25e-03	17	59	2	MM14836
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	PIK3CA PIK3CB	2.25e-03	17	59	2	MM15584
Pathway	REACTOME_SIGNALING_BY_ALK	PIK3CA PIK3CB	2.25e-03	17	59	2	MM14790
Pathway	REACTOME_TIE2_SIGNALING	PIK3CA PIK3CB	2.52e-03	18	59	2	M11932
Pathway	BIOCARTA_IL12_PATHWAY	IL12RB1 STAT4	2.81e-03	19	59	2	MM1417
Pathway	BIOCARTA_IL12_PATHWAY	IL12RB1 STAT4	2.81e-03	19	59	2	M4319
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	CYFIP1 PIK3CA PIK3CB CYFIP2	3.00e-03	143	59	4	M27107
Pathway	REACTOME_SIGNALING_BY_PDGFR_IN_DISEASE	PIK3CA PIK3CB	3.12e-03	20	59	2	M29849
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY	CYFIP1 CYFIP2	3.12e-03	20	59	2	M47737
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	GNB3 ATP2B1 ADCY9 RYR3	3.31e-03	147	59	4	MM15854
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	PIK3CA PIK3CB BID	3.38e-03	72	59	3	M39738
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_CBL	PIK3CA PIK3CB	3.44e-03	21	59	2	MM15633
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	GNB3 ATP2B1 ADCY9 RYR3	3.65e-03	151	59	4	M39329
Pathway	WP_HEPATITIS_B_INFECTION	PIK3CA PIK3CB STAT4 BID	3.65e-03	151	59	4	M39801
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_CBL	PIK3CA PIK3CB	3.77e-03	22	59	2	M903
Pathway	REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING	PIK3CA PIK3CB	3.77e-03	22	59	2	MM15632
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PIK3CA PIK3CB DGKG	3.94e-03	76	59	3	M9052
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ENTPD7 KLHL11 THEM6 OSTC TMEM259 CAMLG MANEAL SLC6A15 TIMELESS EXT1 SEZ6L2 ATP2B1 FANCA	2.96e-06	1201	79	13	35696571
Pubmed	Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase.	PIK3CA PIK3CB	5.09e-06	2	79	2	18285463
Pubmed	State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.	SCN4A SCN9A	5.09e-06	2	79	2	18079277
Pubmed	Association of HLA-DP/DQ, STAT4 and IL-28B variants with HBV viral clearance in Tibetans and Uygurs in China.	STAT4 IFNL3	5.09e-06	2	79	2	25041342
Pubmed	Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells.	PIK3CA PIK3CB	5.09e-06	2	79	2	19509054
Pubmed	The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.	PIK3CA PIK3CB	5.09e-06	2	79	2	22802530
Pubmed	PIP3 abundance overcomes PI3K signaling selectivity in invadopodia.	PIK3CA PIK3CB	5.09e-06	2	79	2	34990021
Pubmed	Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer.	PIK3CA PIK3CB	5.09e-06	2	79	2	27903677
Pubmed	The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type.	PIK3CA PIK3CB	5.09e-06	2	79	2	24991009
Pubmed	The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy.	PIK3CA PIK3CB	5.09e-06	2	79	2	21059846
Pubmed	Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells.	PIK3CA PIK3CB	5.09e-06	2	79	2	23568272
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP1 CYFIP2	5.09e-06	2	79	2	38128786
Pubmed	Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.	PIK3CA PIK3CB	5.09e-06	2	79	2	31363081
Pubmed	The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.	PIK3CA PIK3CB	5.09e-06	2	79	2	21917798
Pubmed	Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2.	DAAM2 DAAM1	5.09e-06	2	79	2	38000028
Pubmed	The STAT4 and not the IFNL3 variant is associated with hepatitis B virus clearance in a population from the Khyber Pakhtunkhwa region of Pakistan.	STAT4 IFNL3	5.09e-06	2	79	2	32439233
Pubmed	The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.	PIK3CA PIK3CB	5.09e-06	2	79	2	16339315
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP1 CYFIP2	5.09e-06	2	79	2	24357318
Pubmed	Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis.	PIK3CA PIK3CB	5.09e-06	2	79	2	21464441
Pubmed	Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming.	PIK3CA PIK3CB	5.09e-06	2	79	2	24903091
Pubmed	Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus.	PIK3CA PIK3CB	5.09e-06	2	79	2	16380997
Pubmed	PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma.	PIK3CA PIK3CB	5.09e-06	2	79	2	25550888
Pubmed	Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.	PIK3CA PIK3CB	5.09e-06	2	79	2	22150431
Pubmed	PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts.	PIK3CA PIK3CB	5.09e-06	2	79	2	19834495
Pubmed	PI3K Catalytic Subunits α and β Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells.	PIK3CA PIK3CB	5.09e-06	2	79	2	31513749
Pubmed	The Phosphoinosotide 3-Kinase Catalytic Subunit p110α is Required for Normal Lens Growth.	PIK3CA PIK3CB	5.09e-06	2	79	2	27304846
Pubmed	The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome.	PIK3CA PIK3CB	5.09e-06	2	79	2	24131925
Pubmed	Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.	DAAM2 DAAM1	5.09e-06	2	79	2	15464228
Pubmed	Expression of Phosphoinositide 3-Kinase p110α and p110β Subunits and PIK3CA Mutation in Patients With Advanced Gastric Carcinoma.	PIK3CA PIK3CB	5.09e-06	2	79	2	28549032
Pubmed	Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase.	PIK3CA PIK3CB	5.09e-06	2	79	2	11919689
Pubmed	Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.	PIK3CA PIK3CB	5.09e-06	2	79	2	23051731
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP1 CYFIP2	5.09e-06	2	79	2	34327661
Pubmed	PIK3CA and PIK3CB silencing by RNAi reverse MDR and inhibit tumorigenic properties in human colorectal carcinoma.	PIK3CA PIK3CB	5.09e-06	2	79	2	26747178
Pubmed	The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma.	PIK3CA PIK3CB	5.09e-06	2	79	2	23318440
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP1 CYFIP2	5.09e-06	2	79	2	29752658
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP1 CYFIP2	5.09e-06	2	79	2	35567753
Pubmed	Distinct epithelial-to-mesenchymal transitions induced by PIK3CAH1047R and PIK3CB.	PIK3CA PIK3CB	5.09e-06	2	79	2	33526718
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP1 CYFIP2	5.09e-06	2	79	2	31324746
Pubmed	Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.	PIK3CA PIK3CB	5.09e-06	2	79	2	29902570
Pubmed	A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.	UBE4A UBE4B	5.09e-06	2	79	2	10089879
Pubmed	p110α and p110β isoforms of PI3K are involved in protection against H2O2 induced oxidative stress in cancer cells.	PIK3CA PIK3CB	5.09e-06	2	79	2	30499025
Pubmed	Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity.	PIK3CA PIK3CB	5.09e-06	2	79	2	24691033
Pubmed	Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.	PIK3CA PIK3CB	5.09e-06	2	79	2	15713620
Pubmed	Expression of PI3Kp110α and PI3Kp110β in the colorectal conventional adenoma, serrated lesions and adenoma with canceration and their significance.	PIK3CA PIK3CB	5.09e-06	2	79	2	26884879
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	CYFIP1 PIK3CA MACF1 SLC6A15 DAAM1 ATP2B1 ADCY9 CYFIP2	5.31e-06	421	79	8	36976175
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	THEM6 UBE4A AFTPH RPAP1 ATP13A1 RSL1D1 CAMLG MACF1 SLC6A15 DAAM1 ZDHHC17 ATP2B1 TOP3B ADCY9	5.90e-06	1487	79	14	33957083
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	THEM6 RPAP1 UBE4B TMEM259 ATP13A1 SLC6A15 TIMELESS BTAF1 ZDHHC17 VCPIP1 FANCA	9.15e-06	942	79	11	31073040
Pubmed	PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells.	PIK3CA PIK3CB	1.53e-05	3	79	2	36812307
Pubmed	Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors.	PIK3CA PIK3CB	1.53e-05	3	79	2	10358930
Pubmed	PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes.	PIK3CA PIK3CB	1.53e-05	3	79	2	21912691
Pubmed	PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.	PIK3CA PIK3CB	1.53e-05	3	79	2	25618408
Pubmed	Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate.	PIK3CA PIK3CB	1.53e-05	3	79	2	25398937
Pubmed	MiR-337-3p suppresses proliferation of epithelial ovarian cancer by targeting PIK3CA and PIK3CB.	PIK3CA PIK3CB	1.53e-05	3	79	2	31629932
Pubmed	Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.	IL12RB1 STAT4	1.53e-05	3	79	2	24238342
Pubmed	The role of different PI3K protein subtypes in the metastasis, angiogenesis and clinical prognosis of hepatocellular carcinoma.	PIK3CA PIK3CB	1.53e-05	3	79	2	34023498
Pubmed	Direct interaction of STAT4 with the IL-12 receptor.	IL12RB1 STAT4	1.53e-05	3	79	2	10415122
Pubmed	Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome.	PIK3CA PIK3CB	1.53e-05	3	79	2	22539774
Pubmed	Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence.	PIK3CA PIK3CB	1.53e-05	3	79	2	17908814
Pubmed	Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.	PIK3CA PIK3CB	1.53e-05	3	79	2	23873941
Pubmed	PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.	PIK3CA PIK3CB	1.53e-05	3	79	2	18187452
Pubmed	Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.	PIK3CA PIK3CB	1.53e-05	3	79	2	20713702
Pubmed	Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity.	PIK3CA PIK3CB	1.53e-05	3	79	2	24958106
Pubmed	Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.	PIK3CA PIK3CB	1.53e-05	3	79	2	20103642
Pubmed	Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.	PIK3CA PIK3CB	1.53e-05	3	79	2	21035500
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN9A	1.53e-05	3	79	2	20038812
Pubmed	Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.	PIK3CA PIK3CB	1.53e-05	3	79	2	15496927
Pubmed	Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophages.	PIK3CA PIK3CB	1.53e-05	3	79	2	17579043
Pubmed	Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.	PIK3CA PIK3CB	1.53e-05	3	79	2	19815551
Pubmed	Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.	PIK3CA PIK3CB	1.53e-05	3	79	2	19883613
Pubmed	A p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of EBV-related B cell origin cancer cells via regulation of NF-κB.	PIK3CA PIK3CB	1.53e-05	3	79	2	28339079
Pubmed	Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.	PIK3CA PIK3CB	1.53e-05	3	79	2	27176780
Pubmed	Purification and characterization of phosphoinositide 3-kinase from rat liver.	PIK3CA PIK3CB	1.53e-05	3	79	2	2174051
Pubmed	Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention.	PIK3CA PIK3CB	1.53e-05	3	79	2	23258246
Pubmed	Identification and comparative expression analyses of Daam genes in mouse and Xenopus.	DAAM2 DAAM1	1.53e-05	3	79	2	15533824
Pubmed	Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts.	PIK3CA PIK3CB	1.53e-05	3	79	2	26896753
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	SPATA7 PIK3CA PIK3CB KCNV2 MACF1 MCOLN1	1.57e-05	233	79	6	32290105
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	CYFIP1 PIK3CA CYFIP2	1.68e-05	22	79	3	21946561
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	THEM6 XRN2 PIK3CA PIK3CB GNB3 PKDREJ	2.66e-05	256	79	6	24189400
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	OSTC TMTC4 ATP13A1 MACF1 SLC6A15 TIMELESS EXT1 BTAF1 SLC45A1 RNF145 ADCY9	2.75e-05	1061	79	11	33845483
Pubmed	ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor.	PIK3CA PIK3CB	3.05e-05	4	79	2	28783168
Pubmed	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility.	PIK3CA PIK3CB	3.05e-05	4	79	2	25269483
Pubmed	Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.	PIK3CA PIK3CB	3.05e-05	4	79	2	21123564
Pubmed	Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury.	PIK3CA PIK3CB	3.05e-05	4	79	2	30496354
Pubmed	Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.	PIK3CA PIK3CB	3.05e-05	4	79	2	11676480
Pubmed	INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.	PIK3CA PIK3CB	3.05e-05	4	79	2	28196852
Pubmed	Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites.	TMTC1 TMTC4	3.05e-05	4	79	2	33436046
Pubmed	PI 3-kinase p110beta: a new target for antithrombotic therapy.	PIK3CA PIK3CB	3.05e-05	4	79	2	15834429
Pubmed	Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas.	PIK3CA PIK3CB	3.05e-05	4	79	2	32997991
Pubmed	CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells.	PIK3CA PIK3CB	3.05e-05	4	79	2	35459184
Pubmed	PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.	PIK3CA PIK3CB	3.05e-05	4	79	2	24737887
Pubmed	Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages.	PIK3CA PIK3CB	3.05e-05	4	79	2	19033389
Pubmed	Skeletal muscle PI3K p110β regulates expression of AMP-activated protein kinase.	PIK3CA PIK3CB	3.05e-05	4	79	2	27965101
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP1 CYFIP2	3.05e-05	4	79	2	15294869
Pubmed	Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.	TMTC1 TMTC4	3.05e-05	4	79	2	28973932
Pubmed	Activity of any class IA PI3K isoform can sustain cell proliferation and survival.	PIK3CA PIK3CB	3.05e-05	4	79	2	20534549
Pubmed	Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.	DAAM2 DAAM1	3.05e-05	4	79	2	33974241
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP1 CYFIP2	3.05e-05	4	79	2	27605705
Pubmed	Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.	PIK3CA PIK3CB	3.05e-05	4	79	2	18594509
Pubmed	PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter.	PIK3CA PIK3CB	3.05e-05	4	79	2	27022680
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP1 CYFIP2	3.05e-05	4	79	2	20228810
Interaction	RHOC interactions	THEM6 CYFIP1 TMEM185B RSL1D1 KIF14 MACF1 DAAM2 SLC6A15 DAAM1 ATP2B1 TOP3B ADCY9	2.38e-06	584	78	12	int:RHOC
Interaction	C3orf18 interactions	UBE4A ATP13A1 KIF14 TIMELESS BTAF1 TOP3B	5.57e-06	115	78	6	int:C3orf18
Interaction	LAMP1 interactions	RNF167 CYFIP1 ATP13A1 PIK3CA PIK3CB CAMLG MACF1 SLC6A15 ATP2B1 ADCY9 CYFIP2 SLC30A6	6.47e-06	644	78	12	int:LAMP1
Interaction	TPST2 interactions	ATP13A1 CAMLG SCN4A MCOLN1 ATP2B1 TOP3B	8.59e-06	124	78	6	int:TPST2
Interaction	GPR182 interactions	THEM6 RPAP1 TMEM259 TIMELESS BTAF1 ZDHHC17 ATP2B1 CYFIP2 SLC30A6 FANCA	9.95e-06	455	78	10	int:GPR182
Interaction	RHOA interactions	THEM6 CYFIP1 TMEM185B ATP13A1 RSL1D1 CAMLG KIF14 MACF1 SLC6A15 DAAM1 ATP2B1 TOP3B ADCY9 CYFIP2 SLC30A6 BID	1.16e-05	1199	78	16	int:RHOA
Interaction	AMZ1 interactions	CYFIP1 UBE4B CYFIP2 FANCA	2.51e-05	44	78	4	int:AMZ1
Interaction	RAC3 interactions	THEM6 CYFIP1 PIK3CA RSL1D1 KIF14 MACF1 SLC6A15 DAAM1 ATP2B1 ADCY9 CYFIP2	2.53e-05	619	78	11	int:RAC3
Interaction	ATP2A1 interactions	OSTC RNF167 ATP13A1 CAMLG KIF14 SLC6A15 EXT1 ATP2B1 ADCY9	3.68e-05	423	78	9	int:ATP2A1
Interaction	ERGIC1 interactions	ATP13A1 CAMLG KIF14 SLC6A15 ATP2B1 ADCY9 SLC30A6	7.31e-05	264	78	7	int:ERGIC1
Cytoband	12q21.3	SLC6A15 ATP2B1	8.76e-06	3	79	2	12q21.3
Cytoband	1p36.23	TAS1R1 SLC45A1	2.63e-04	14	79	2	1p36.23
Cytoband	5q33.3	RNF145 CYFIP2	1.77e-03	36	79	2	5q33.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q21	SLC6A15 ZDHHC17 ATP2B1	1.89e-03	141	79	3	chr12q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	IL12RB1 P2RY11 TMEM259 ATP13A1 FAM174C MCOLN1	2.55e-03	797	79	6	chr19p13
GeneFamily	U-box domain containing	UBE4A UBE4B	1.62e-04	7	51	2	365
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3CA PIK3CB	2.16e-04	8	51	2	831
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN9A	2.77e-04	9	51	2	1203
GeneFamily	EF-hand domain containing	CAPN9 DGKG MACF1 RYR3	3.35e-03	219	51	4	863
GeneFamily	Potassium voltage-gated channels	KCNV2 KCNG4	5.68e-03	40	51	2	274
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_500_k-means-cluster#4	FZD3 SLC22A23 MACF1 DAAM1 CYFIP2	3.05e-05	98	78	5	Facebase_RNAseq_e10.5_Olfactory Pit_500_K4
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	TMTC1 EXT1 LILRA5 CYFIP2 STAT4 BID	1.24e-06	193	79	6	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 NIPAL2 DGKG DAAM2 STAT4	9.44e-06	159	79	5	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPATA7 PCDHB10 KIF14 TIMELESS RYR3	1.10e-05	164	79	5	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPATA7 PCDHB10 KIF14 TIMELESS RYR3	1.10e-05	164	79	5	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 NIPAL2 DGKG DAAM2	1.31e-05	170	79	5	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 NIPAL2 DGKG DAAM2	1.31e-05	170	79	5	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 NIPAL2 DGKG DAAM2 STAT4	1.31e-05	170	79	5	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 NIPAL2 DGKG DAAM2 STAT4	1.31e-05	170	79	5	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 NIPAL2 DGKG DAAM2	1.31e-05	170	79	5	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATA7 DGKG TIMELESS STAT4 TGS1	1.96e-05	185	79	5	969248b63d4ce335f223528de756bcddffadbd77
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2 STAT4	2.07e-05	187	79	5	ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2 STAT4	2.07e-05	187	79	5	530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCell	Sepsis-Leuk-UTI-Others\|Leuk-UTI / Disease, condition lineage and cell class	OSTC FZD3 SCN9A DAAM1 ZDHHC17	2.78e-05	199	79	5	e45fe91f1d1c47a305b0f39d808730723852af00
ToppCell	Sepsis-Leuk-UTI-Others-RBC\|Leuk-UTI / Disease, condition lineage and cell class	OSTC FZD3 SCN9A DAAM1 ZDHHC17	2.78e-05	199	79	5	d9b517199a646c9461c615412ad5b58cf4bed7c8
ToppCell	LPS-antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEYL KIF14 DAAM2 RYR3	8.97e-05	132	79	4	02491930097b75aaeedab9e8200711b0dc610944
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Sc17a7.Tshz2-Smoc1_(Agranular_Retrosplenial_cortex_(RSG)_(Smoc1+))-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	OR5AU1 SCN4A GNB3	9.06e-05	49	79	3	4845246699a56fea657fd2697b612e93248f590f
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Sc17a7.Tshz2-Smoc1_(Agranular_Retrosplenial_cortex_(RSG)_(Smoc1+))\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	OR5AU1 SCN4A GNB3	9.06e-05	49	79	3	5f1c5ebb6f113513b7e6945dfab07c3c34ebab41
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GPR26 ATP2B1 KCNK4 RYR3	1.36e-04	147	79	4	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	TMEM259 MACF1 BTAF1 STAT4	1.36e-04	147	79	4	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 TAS1R1 DGKG DAAM2	1.39e-04	148	79	4	f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 TAS1R1 DGKG DAAM2	1.39e-04	148	79	4	4b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 TAS1R1 DGKG DAAM2	1.39e-04	148	79	4	55826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCN4A PCDHB10 KIF14 SEZ6L2	1.58e-04	153	79	4	c1335e7d7407412431ed4d8c7dfcb2c6086d8483
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEYL CLVS2 DGKG DAAM2	1.71e-04	156	79	4	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE4A FZD3 NIPAL2 CYFIP2	1.75e-04	157	79	4	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL11 SCN9A DAAM2 PKDREJ	1.79e-04	158	79	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL11 SCN9A DAAM2 PKDREJ	1.79e-04	158	79	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMTC4 DGKG DAAM2 TIMELESS	1.93e-04	161	79	4	bf70be1de418615b5442ec684552551edaf1f072
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TBC1D13 SLC22A23 SEZ6L2 LGALS4	2.07e-04	164	79	4	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	2.12e-04	165	79	4	4f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	2.12e-04	165	79	4	cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLVS2 SLC6A15 KCNK4 RYR3	2.21e-04	167	79	4	3dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLVS2 SLC6A15 KCNK4 RYR3	2.21e-04	167	79	4	95b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLVS2 SLC6A15 KCNK4 RYR3	2.21e-04	167	79	4	9480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENTPD7 TBC1D13 ZDHHC17 ADCY9	2.27e-04	168	79	4	de1042267407719f19eb3f580a5df0c9cd0e8273
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-Th17\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL12RB1 DET1 STAT4 SLC30A6	2.27e-04	168	79	4	97bf074b91c9ae0064edc31fa4a2658ffdcfefa3
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3CB MANEAL LGALS4 FANCA	2.32e-04	169	79	4	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 MANEAL CYFIP2 STAT4	2.32e-04	169	79	4	8028622ff362d70d1002e65a74ade46ea7f1f13f
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL11 IL12RB1 MANEAL KIF14	2.48e-04	172	79	4	e495efd25aec60b97ac2b5aa861651bd73174a17
ToppCell	367C-Lymphocytic-ILC-ILC-2\|367C / Donor, Lineage, Cell class and subclass (all cells)	TOP3B ITPRIPL1 STAT4 SLC30A6	2.53e-04	173	79	4	0451450605521fecb27a958628870d268adfb023
ToppCell	droplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLHL11 IL12RB1 MANEAL KIF14	2.70e-04	176	79	4	b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATA7 PIK3CA BTAF1 LILRA5	2.70e-04	176	79	4	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	(01)_Cycling_Basal_(homeostasis)-(1)_24hpi\|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint	THEM6 NAPRT ADCY9	2.73e-04	71	79	3	6aa56b0daaeb5e0ae30619f9c6945c8e42899b27
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	2.76e-04	177	79	4	4943d040eee0f9dceaddc7498171281d170e271f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	2.76e-04	177	79	4	3f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLVS2 SCN9A SLC45A1 SEZ6L2	2.82e-04	178	79	4	d3a75a8082e70543b84c35d53fe77625300d19fa
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	OR5AU1 CLVS2 MANEAL SCN9A	2.82e-04	178	79	4	38ffbd01230c99f52274424ee6c172381daffc73
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLVS2 SCN9A SLC45A1 SEZ6L2	2.82e-04	178	79	4	b2cda1df801b1a1a41e3dd2808baef37765cd804
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	TMTC1 NIPAL2 DGKG DAAM2	2.88e-04	179	79	4	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	Severe-Lymphoid-pDC\|Severe / Condition, Lineage, Cell class and cell subclass	TBC1D13 SCN9A ZDHHC17 CYFIP2	3.01e-04	181	79	4	2caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCell	Severe-Lymphoid-pDC-\|Severe / Condition, Lineage, Cell class and cell subclass	TBC1D13 SCN9A ZDHHC17 CYFIP2	3.01e-04	181	79	4	277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	HEYL TMTC1 CLVS2 DAAM2	3.14e-04	183	79	4	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEYL CLVS2 DGKG DAAM2	3.14e-04	183	79	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.14e-04	183	79	4	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CYFIP1 P2RY11 NAPRT VCPIP1	3.20e-04	184	79	4	2c2125b8030af83f7a6d59a7102d4de8e0ac1988
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN9A SLC6A15 SLC45A1 SEZ6L2	3.20e-04	184	79	4	3e5c68a99c10eb1ddc1048bea4aa9f6b8e2746ff
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEYL CLVS2 DGKG DAAM2	3.20e-04	184	79	4	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN9A SLC6A15 SLC45A1 SEZ6L2	3.20e-04	184	79	4	1e2f0cec50475a1cf2973a5082826bbc60fc9a68
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEYL CLVS2 DGKG DAAM2	3.20e-04	184	79	4	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.27e-04	185	79	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	Leuk-UTI-Other-RBC\|Leuk-UTI / Disease, Lineage and Cell Type	OSTC SCN9A DAAM1 ZDHHC17	3.27e-04	185	79	4	5b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMTC1 METTL22 CYFIP2 RYR3	3.27e-04	185	79	4	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.27e-04	185	79	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	Leuk-UTI-Other\|Leuk-UTI / Disease, Lineage and Cell Type	OSTC SCN9A DAAM1 ZDHHC17	3.27e-04	185	79	4	895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Monocytic-Nonclassical_monocytes\|lymph-node_spleen / Manually curated celltypes from each tissue	TMTC1 MCOLN1 LILRA5 BID	3.34e-04	186	79	4	d7da5edb2ee36f96cdd7e27eb9afcc1cbfd52bb6
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HEYL CLVS2 DGKG DAAM2	3.34e-04	186	79	4	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR26 PIK3CA SCN9A SLC45A1	3.34e-04	186	79	4	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR26 CLVS2 SLC6A15 SLC45A1	3.34e-04	186	79	4	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CLVS2 MANEAL SCN9A CYFIP2	3.40e-04	187	79	4	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.40e-04	187	79	4	48bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCell	CF-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	ENTPD7 FZD3 SCN9A LILRA5	3.40e-04	187	79	4	adc79e5804ab98006dbdf1d76ef0d8f85cc5cb0f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 NIPAL2 DGKG DAAM2	3.40e-04	187	79	4	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	COPD-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	HEYL DGKG DAAM2 STAT4	3.40e-04	187	79	4	406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	ENTPD7 SCN9A ZDHHC17 LILRA5	3.40e-04	187	79	4	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 NIPAL2 DGKG DAAM2	3.40e-04	187	79	4	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.40e-04	187	79	4	958402fcc78f4c7a7d13d659d776f3817137975f
ToppCell	Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, Lineage and Cell Type	OSTC SCN9A DAAM1 ZDHHC17	3.40e-04	187	79	4	e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-non-classical_monocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TMTC1 MCOLN1 LILRA5 BID	3.47e-04	188	79	4	3e94d105ca96ceb5fdcca39a8050217913bc02da
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	DGKG MACF1 EXT1 RYR3	3.47e-04	188	79	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 NIPAL2 DGKG DAAM2	3.47e-04	188	79	4	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HEYL TMTC1 SLC22A23 RYR3	3.54e-04	189	79	4	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	Int-URO-Myeloid-pDC\|Int-URO / Disease, Lineage and Cell Type	OSTC SCN9A DAAM1 ZDHHC17	3.54e-04	189	79	4	37aee7a0acd5fd5dd62f22608d72ff8afe210e5c
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	TMTC1 EXT1 LILRA5 CYFIP2	3.54e-04	189	79	4	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	CLVS2 SLC22A23 CYFIP2 RYR3	3.54e-04	189	79	4	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	DGKG MACF1 EXT1 RYR3	3.54e-04	189	79	4	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.54e-04	189	79	4	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	COPD-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	TMTC1 EXT1 LILRA5 BID	3.62e-04	190	79	4	aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	TMTC1 EXT1 LILRA5 CYFIP2	3.62e-04	190	79	4	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	COVID-19-kidney-vSMC/Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	HEYL TMTC1 DGKG DAAM2	3.69e-04	191	79	4	fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCell	Control-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	HEYL DGKG DAAM2 CYFIP2	3.69e-04	191	79	4	2da83c493e60ad0278848957645277d76737a188
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.69e-04	191	79	4	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.69e-04	191	79	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.69e-04	191	79	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	BAL-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBC1D13 SCN9A ZDHHC17 CYFIP2	3.76e-04	192	79	4	d9ff2293358c8b031ba212021012e058014ff472
ToppCell	Severe_COVID-19-Myeloid-pDC\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	TBC1D13 SCN9A ZDHHC17 CYFIP2	3.76e-04	192	79	4	f79424c643a375dfe4579eff7ac1ba191e28a283
ToppCell	BAL-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBC1D13 SCN9A ZDHHC17 CYFIP2	3.76e-04	192	79	4	2e8611d65090e39f1a6e74c972288e7b68376d15
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.76e-04	192	79	4	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	IPF-Myeloid-ncMonocyte\|IPF / Disease state, Lineage and Cell class	TMTC1 EXT1 LILRA5 BID	3.76e-04	192	79	4	e9fb8c57d8094f70fb492909b2bec40aa5f2e5b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEYL TMTC1 DGKG DAAM2	3.76e-04	192	79	4	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	Control-Myeloid-cMonocyte\|Control / Disease state, Lineage and Cell class	DAAM2 EXT1 ATP2B1 LILRA5	3.76e-04	192	79	4	ad04c9c4bdebf94615cee1904ca48197e62c923b
Drug	Methoxy-8-psoralen [298-81-7]; Up 200; 18.6uM; MCF7; HT_HG-U133A	ENTPD7 CAPN9 TMEM259 NIPAL2 ZDHHC17 MCOLN1 LILRA5	5.23e-06	195	79	7	5007_UP
Drug	enprofylline	P2RY11 PIK3CA PIK3CB ADCY9	7.27e-06	36	79	4	CID000001676
Drug	nsc25485	TMTC1 PIK3CA PIK3CB SCN4A SCN9A GNB3 ATP2B1 ADCY9	1.28e-05	312	79	8	CID000004605
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP1 CYFIP2	1.91e-05	3	75	2	DOID:0060393 (implicated_via_orthology)
Disease	Schizophrenia	CYFIP1 FZD3 PIK3CA PIK3CB CLVS2 DAAM2 GNB3 TOP3B BID IFNL3	7.81e-05	883	75	10	C0036341
Disease	Malignant neoplasm of breast	OSTC HEYL TMTC4 PIK3CA PIK3CB DGKG MACF1 TIMELESS PKDREJ MCOLN1 STAT4	8.20e-05	1074	75	11	C0006142
Disease	hepatocellular carcinoma	DET1 STAT4 IFNL3	1.57e-04	41	75	3	EFO_0000182
Disease	Malignant Head and Neck Neoplasm	PIK3CA PIK3CB FANCA	1.94e-04	44	75	3	C0278996
Disease	Head and Neck Carcinoma	PIK3CA PIK3CB	2.83e-04	10	75	2	C3887461
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN9A	2.83e-04	10	75	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN9A	2.83e-04	10	75	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN9A	4.14e-04	12	75	2	DOID:0060170 (implicated_via_orthology)
Disease	chronic obstructive pulmonary disease	HEYL TMTC1 CYP2B6 RPAP1 TMEM267 FZD3 DGKG	1.83e-03	688	75	7	EFO_0000341
Disease	glucose metabolism disease (implicated_via_orthology)	PIK3CB DGKG	2.31e-03	28	75	2	DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSFRIFRLVGCALLA	CAMLG	186	P49069
CLGEGIARAELFLFF	CYP2B6	436	P20813
TALLNRLERIFEACF	AFTPH	646	Q6ULP2
FCLALLADRVLQFFL	ATP13A1	1181	Q9HD20
LLELFENFCDLFRNA	DET1	386	Q7L5Y6
ASEGLRTICLAFRDF	ATP2B1	641	P20020
NRFLLLFIGFVCVLL	OSTC	116	Q9NRP0
GQFFDLSIRCGLDRF	LGALS4	271	P56470
CARSLLRGFLLQNEF	MCOLN1	316	Q9GZU1
VLLGQQRRFAVLDFC	CYFIP1	1166	Q7L576
TRFIELEGLTCLLNF	DAAM2	146	Q86T65
LLERAFEGFNTCLFA	KIF14	431	Q15058
ACRLERFLFTCNLLG	P2RY11	101	Q96G91
QCGSRLRFDRFILTE	LILRA5	161	A6NI73
RQRVAFLGLFFISCL	ENTPD7	26	Q9NQZ7
RGSFRCLVNLRFLDL	LRRIQ4	296	A6NIV6
CGLTALYFLIRAFRL	FAM174C	81	Q9BVV8
LRTDAGRLFCIFYAL	KCNK4	111	Q9NYG8
RCTREFGLLLLFLAV	KCNG4	366	Q8TDN1
DRLCRLAAFLDTFLA	GPR26	76	Q8NDV2
ALAVDFRSIGFRECL	HEYL	111	Q9NQ87
RLFDLRADQELICFS	GNB3	251	P16520
LCFPRQRQVLFLFLF	PCDHB10	6	Q9UN67
LLGQQRRFDLFDFCY	CYFIP2	1191	Q96F07
EFFDETRRLCDLRLF	PIK3CA	81	P42336
LEFIRILGADLIFAC	MACF1	6061	Q9UPN3
GLFCLFLVFELLRQN	ITPRIPL1	116	Q6GPH6
RFIDLDGLSCILNFL	DAAM1	151	Q9Y4D1
LNFFRDTPDFRVLAC	DGKG	476	P49619
DRFLLIRLKEFCGEF	KLHL11	181	Q9NVR0
RLGSFRFLEALQAAC	EXT1	341	Q16394
DLVIRLLCVFALDRF	BTAF1	341	O14981
LLCVFALDRFGDFVS	BTAF1	346	O14981
CEREELLVFLFFFSL	FANCA	1251	O15360
FNLFRLLTRDLNCVA	IFNL3	176	Q8IZI9
VGLLNDLFGRFDRLC	ADCY9	416	O60503
LRDECITNLLVFGFL	BID	11	P55957
LLFLFLLSRQGAACR	IL12RB1	11	P42701
RRACIALFLVLLFAF	MANEAL	6	Q5VSG8
CFGDRFSRLLLDEFL	TMEM259	246	Q4ZIN3
IFFIGFLLEDRVACN	FZD3	251	Q9NPG1
FLNCLVRLENASRVF	CAPN9	651	O14815
RSFRELLFNGCILFG	SLC45A1	116	Q9Y2W3
CVKGLELFSLFLFRD	DROSHA	641	Q9NRR4
ICFLIRAFLLNGSID	SLC6A15	266	Q9H2J7
ILARGFCVDDFTFLR	SCN4A	176	P35499
RFVSLRDGFVCALLR	THEM6	136	Q8WUY1
RDFCQFLLEIFPFLR	TMEM185B	276	Q9H7F4
LRFFEGFCLAGIILT	SLC22A23	286	A1A5C7
CFLSFLGVFLVTRNR	NIPAL2	316	Q9H841
CEILLFIFAGFNLLS	OR5AU1	246	Q8NGC0
CERNFIVSDRFSLFL	PKDREJ	466	Q9NTG1
RFFAFLCIAFGIILN	KCNV2	471	Q8TDN2
SVFIALLRRFDCNFD	RNF167	81	Q9H6Y7
ILARGFCVGEFTFLR	SCN9A	171	Q15858
LLSLRFEAFEEDRCF	SEZ6L2	451	Q6UXD5
YILFRQDLFRGCTAL	METTL22	196	Q9BUU2
FLDCALSRFLLERAL	PIK3CB	651	P42338
FLRTDDAFILRFLRA	CLVS2	46	Q5SYC1
RQELDLRIGCAFTRF	TOP3B	181	O95985
LNVRLFLRDFCSEFL	TIMELESS	336	Q9UNS1
GRADLLCALFFLLSF	TMTC4	171	Q5T4D3
GRADVLACLLFLLAF	TMTC1	166	Q8IUR5
CLLRQALFALGFTIF	TAS1R1	631	Q7RTX1
SFDFFLTDARIRRLL	RSL1D1	151	O76021
FTRDLFRFLQLLCEG	RYR3	3731	Q15413
CFTLLAESLFQLRRQ	STAT4	261	Q14765
DESFLRRCLNFYGLL	UBE4B	836	O95155
CAEGEFIFLRLNVLR	XRN2	296	Q9H0D6
LGLFSNRFLERLFER	SPATA7	381	Q9P0W8
LFADDNRFDFLLLVC	TBC1D13	341	Q9NVG8
LAAGLRDCVRFLRAF	NAPRT	56	Q6XQN6
AGFLFLLRFSLDDRV	RPAP1	441	Q9BWH6
ELFDCALLGDRAFLI	VCPIP1	156	Q96JH7
VRNIIDFFEFRCCGL	ZDHHC17	591	Q8IUH5
RLLVGTFVALCFNLF	SLC30A6	136	Q6NXT4
NLGDFLIFLRRFADD	UBE4A	631	Q14139
IEFICGDFLLLASFL	TGS1	741	Q96RS0
RERLLFLFLTSIAEC	RNF145	256	Q96MT1
LGAFCLVADRLLQFS	TMEM267	26	Q0VDI3