Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

PITPNM1 HSPG2 FBLN7 HMCN2 COMP PDP1 GNPTAB CRNN PCDH8 NOTCH1 NOTCH3 ALPL

2.78e-057497712GO:0005509
GeneOntologyMolecularFunctionphosphoglucomutase activity

PGM1 PGM5

4.39e-053772GO:0004614
MousePhenoPurkinje cell axonal dystrophy

GNPTAB HERC2

2.00e-052632MP:0013159
DomainLNR

GNPTAB NOTCH1 NOTCH3

6.70e-075773PS50258
DomainNotch_dom

GNPTAB NOTCH1 NOTCH3

2.33e-067773IPR000800
DomainNotch

GNPTAB NOTCH1 NOTCH3

2.33e-067773PF00066
DomainNL

GNPTAB NOTCH1 NOTCH3

2.33e-067773SM00004
DomainEGF_CA

HSPG2 FBLN7 HMCN2 COMP NOTCH1 NOTCH3

1.11e-05122776SM00179
DomainEGF-like_Ca-bd_dom

HSPG2 FBLN7 HMCN2 COMP NOTCH1 NOTCH3

1.22e-05124776IPR001881
DomainPhos_transporter

SLC20A1 SLC20A2

1.68e-052772IPR001204
DomainPHO4

SLC20A1 SLC20A2

1.68e-052772PF01384
DomainEGF_CA

FBLN7 HMCN2 COMP NOTCH1 NOTCH3

2.80e-0586775PF07645
DomainGrowth_fac_rcpt_

EPHB3 HSPG2 HMCN2 COMP NOTCH1 NOTCH3

4.48e-05156776IPR009030
DomainEGF_Ca-bd_CS

FBLN7 HMCN2 COMP NOTCH1 NOTCH3

5.01e-0597775IPR018097
DomainMYT1

MYT1L MYT1

5.02e-053772PF08474
DomainMyelin_TF

MYT1L MYT1

5.02e-053772IPR013681
DomainDUF3454

NOTCH1 NOTCH3

5.02e-053772PF11936
DomainDUF3454_notch

NOTCH1 NOTCH3

5.02e-053772IPR024600
DomainDUF3454

NOTCH1 NOTCH3

5.02e-053772SM01334
DomainEGF_3

HSPG2 FBLN7 HMCN2 COMP MUC4 NOTCH1 NOTCH3

5.20e-05235777PS50026
DomainEGF_CA

FBLN7 HMCN2 COMP NOTCH1 NOTCH3

5.52e-0599775PS01187
DomainRCC1

HERC3 HERC2 HERC6

7.30e-0520773PF00415
DomainEGF-like_dom

HSPG2 FBLN7 HMCN2 COMP MUC4 NOTCH1 NOTCH3

7.48e-05249777IPR000742
DomainRCC1_1

HERC3 HERC2 HERC6

8.49e-0521773PS00625
DomainRCC1_2

HERC3 HERC2 HERC6

8.49e-0521773PS00626
DomainRCC1_3

HERC3 HERC2 HERC6

8.49e-0521773PS50012
DomainEGF_1

HSPG2 FBLN7 HMCN2 COMP MUC4 NOTCH1 NOTCH3

8.68e-05255777PS00022
DomainReg_chr_condens

HERC3 HERC2 HERC6

9.81e-0522773IPR000408
Domain-

HERC3 HERC2 HERC6

9.81e-05227732.130.10.30
DomainNotch

NOTCH1 NOTCH3

1.00e-044772IPR008297
DomainNODP

NOTCH1 NOTCH3

1.00e-044772PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH3

1.00e-044772IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH3

1.00e-044772IPR010660
DomainPGM_PMM_III

PGM1 PGM5

1.00e-044772PF02880
DomainA-D-PHexomutase_CS

PGM1 PGM5

1.00e-044772IPR016066
DomainNOD

NOTCH1 NOTCH3

1.00e-044772PF06816
DomainNOD

NOTCH1 NOTCH3

1.00e-044772SM01338
DomainNODP

NOTCH1 NOTCH3

1.00e-044772SM01339
DomainA-D-PHexomutase_a/b/a-III

PGM1 PGM5

1.00e-044772IPR005846
DomainEGF-like_CS

HSPG2 FBLN7 HMCN2 COMP MUC4 NOTCH1 NOTCH3

1.00e-04261777IPR013032
DomainEGF_2

HSPG2 FBLN7 HMCN2 COMP MUC4 NOTCH1 NOTCH3

1.10e-04265777PS01186
DomainRCC1/BLIP-II

HERC3 HERC2 HERC6

1.12e-0423773IPR009091
DomainPGM_PMM

PGM1 PGM5

1.66e-045772PS00710
DomainPGM_PMM_II

PGM1 PGM5

1.66e-045772PF02879
DomainPGM_PMM_I

PGM1 PGM5

1.66e-045772PF02878
DomainPGM_PMM_IV

PGM1 PGM5

1.66e-045772PF00408
Domain-

PGM1 PGM5

1.66e-0457723.40.120.10
DomainA-D-PHexomutase_a/b/a-I/II/III

PGM1 PGM5

1.66e-045772IPR016055
Domain-

PGM1 PGM5

1.66e-0457723.30.310.50
DomainA-D-PHexomutase_a/b/a-I

PGM1 PGM5

1.66e-045772IPR005844
DomainA-D-PHexomutase_a/b/a-II

PGM1 PGM5

1.66e-045772IPR005845
DomainA-D-PHexomutase_C

PGM1 PGM5

1.66e-045772IPR005843
DomainAlpha-D-phosphohexomutase_SF

PGM1 PGM5

1.66e-045772IPR005841
DomainEGF

HSPG2 FBLN7 MUC4 NOTCH1 NOTCH3

1.73e-04126775PF00008
DomainHECT

HERC3 HERC2 HERC6

1.84e-0427773PF00632
DomainHECTc

HERC3 HERC2 HERC6

1.84e-0427773SM00119
DomainHECT_dom

HERC3 HERC2 HERC6

1.84e-0427773IPR000569
DomainHECT

HERC3 HERC2 HERC6

1.84e-0427773PS50237
DomainGOLGA6L

GOLGA6L9 GOLGA6L4

2.49e-046772IPR026737
DomainZnf_C2HC

MYT1L MYT1

2.49e-046772IPR002515
Domainzf-C2HC

MYT1L MYT1

2.49e-046772PF01530
DomainZF_CCHHC

MYT1L MYT1

3.48e-047772PS51802
DomainEGF

HSPG2 FBLN7 COMP MUC4 NOTCH1 NOTCH3

4.19e-04235776SM00181
DomainASX_HYDROXYL

FBLN7 HMCN2 NOTCH1 NOTCH3

7.76e-04100774PS00010
DomainWD40_repeat

WDR83 WDR18 WDR86 HERC2 WDR26 SHKBP1

9.01e-04272776IPR001680
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN7 HMCN2 NOTCH1 NOTCH3

9.65e-04106774IPR000152
DomainWD_REPEATS_1

WDR83 WDR18 WDR86 HERC2 WDR26 SHKBP1

1.01e-03278776PS00678
DomainWD_REPEATS_2

WDR83 WDR18 WDR86 HERC2 WDR26 SHKBP1

1.03e-03279776PS50082
DomainWD_REPEATS_REGION

WDR83 WDR18 WDR86 HERC2 WDR26 SHKBP1

1.03e-03279776PS50294
DomainPP2C_BS

PPM1D PDP1

1.08e-0312772IPR000222
DomainPPM_1

PPM1D PDP1

1.70e-0315772PS01032
DomainPP2C

PPM1D PDP1

2.19e-0317772IPR015655
DomainGOLGA2L5

GOLGA6L9 GOLGA6L4

2.46e-0318772PF15070
DomainGolgin_A

GOLGA6L9 GOLGA6L4

2.46e-0318772IPR024858
DomainPP2C

PPM1D PDP1

2.74e-0319772PF00481
DomainPP2Cc

PPM1D PDP1

3.04e-0320772SM00332
DomainPPM-type_phosphatase_dom

PPM1D PDP1

3.04e-0320772IPR001932
Domain-

PPM1D PDP1

3.04e-03207723.60.40.10
DomainPPM_2

PPM1D PDP1

3.04e-0320772PS51746
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH3

1.65e-045582M27411
PathwayREACTOME_SODIUM_COUPLED_PHOSPHATE_COTRANSPORTERS

SLC20A1 SLC20A2

1.65e-045582M27345
PathwayREACTOME_SODIUM_COUPLED_PHOSPHATE_COTRANSPORTERS

SLC20A1 SLC20A2

1.65e-045582MM15085
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH3

1.65e-045582MM14733
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH3

2.47e-046582M27068
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

HSPG2 MUC4 NOTCH1 PGM1 NOTCH3

2.98e-04143585M27275
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH3

3.45e-047582MM14734
PathwayWP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT

NOTCH1 NOTCH3 ALPL

3.61e-0434583M39390
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FAM120A HMCN2 TTC28 HMGXB4 FBRSL1 CRNN PEX1 OAS3 MTO1 WDR26 UNC80 ALPL ZNF646

1.14e-061116781331753913
Pubmed

Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2.

SLC20A1 SLC20A2

4.97e-06278229551636
Pubmed

Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.

SLC20A1 SLC20A2

4.97e-06278223968976
Pubmed

Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature.

NOTCH1 NOTCH3

4.97e-06278234878922
Pubmed

Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability.

SLC20A1 SLC20A2

4.97e-06278238195526
Pubmed

Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life.

SLC20A1 SLC20A2

4.97e-06278221586110
Pubmed

Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors.

MYT1L MYT1

4.97e-06278229291346
Pubmed

Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.

SLC20A1 SLC20A2

4.97e-06278212205090
Pubmed

The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance.

NOTCH1 NOTCH3

4.97e-06278226634853
Pubmed

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.

NOTCH1 NOTCH3

4.97e-06278221191019
Pubmed

Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.

ACVR1 NOTCH1

4.97e-06278211290335
Pubmed

Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk.

NOTCH1 NOTCH3

4.97e-06278217881497
Pubmed

A family of retroviruses that utilize related phosphate transporters for cell entry.

SLC20A1 SLC20A2

4.97e-0627827966619
Pubmed

Inorganic phosphate regulates Glvr-1 and -2 expression: role of calcium and ERK1/2.

SLC20A1 SLC20A2

4.97e-06278219232318
Pubmed

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

NOTCH1 NOTCH3

4.97e-06278229023469
Pubmed

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.

SLC20A1 SLC20A2

4.97e-06278232080237
Pubmed

Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer.

NOTCH1 NOTCH3

4.97e-06278224728738
Pubmed

Distinct roles for Notch1 and Notch3 in human adipose-derived stem/stromal cell adipogenesis.

NOTCH1 NOTCH3

4.97e-06278233021719
Pubmed

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations.

NOTCH1 NOTCH3

4.97e-06278226563570
Pubmed

Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation.

NOTCH1 NOTCH3

4.97e-06278214595837
Pubmed

Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.

NOTCH1 NOTCH3

4.97e-06278221768299
Pubmed

Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.

SLC20A1 SLC20A2

4.97e-06278217494632
Pubmed

Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway.

NOTCH1 NOTCH3

4.97e-06278225700162
Pubmed

Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage.

COMP NOTCH1

4.97e-06278229981303
Pubmed

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

SLC20A1 SLC20A2

4.97e-0627828041748
Pubmed

Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis.

NOTCH1 NOTCH3

4.97e-06278218069660
Pubmed

Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.

NOTCH1 NOTCH3

4.97e-06278216507912
Pubmed

A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily.

PGM1 PGM5

4.97e-0627828631316
Pubmed

Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.

SLC20A1 SLC20A2

4.97e-06278216790504
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

ARFGEF3 NHSL1 FAM120A DCP1B TTC28 MPDZ

7.85e-0620978636779422
Pubmed

Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.

EPHB3 NOTCH1 NOTCH3

1.40e-052178324583262
Pubmed

Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro.

NOTCH1 NOTCH3

1.49e-05378215987768
Pubmed

Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

COMP NOTCH3

1.49e-05378230502484
Pubmed

Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.

NOTCH1 NOTCH3

1.49e-0537827615640
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH1 NOTCH3

1.49e-05378225846406
Pubmed

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.

NOTCH1 NOTCH3

1.49e-0537827918097
Pubmed

Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

NOTCH1 NOTCH3

1.49e-0537828645602
Pubmed

A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9.

PGM1 PGM5

1.49e-0537828586438
Pubmed

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression.

NOTCH1 NOTCH3

1.49e-05378231346528
Pubmed

PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study.

NOTCH1 NOTCH3

1.49e-05378234846251
Pubmed

Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study.

NOTCH1 NOTCH3

1.49e-05378221471519
Pubmed

PACT increases mammalian embryonic neural stem cell properties by facilitating activation of the notch signaling pathway.

NOTCH1 PRKRA

1.49e-05378230967258
Pubmed

Smooth muscle Notch1 mediates neointimal formation after vascular injury.

NOTCH1 NOTCH3

1.49e-05378219433762
Pubmed

Effect of notch1,2,3 genes silicing on NF-κB signaling pathway of macrophages in patients with atherosclerosis.

NOTCH1 NOTCH3

1.49e-05378227697639
Pubmed

Assignment of the perlecan (heparan sulfate proteoglycan) gene to mouse chromosome 4.

HSPG2 ALPL

1.49e-0537821686572
Pubmed

NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.

NOTCH1 NOTCH3

1.49e-05378220801121
Pubmed

Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.

NOTCH1 NOTCH3

1.49e-05378218483410
Pubmed

Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.

MYT1L MYT1

1.49e-05378230312684
Pubmed

KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.

NOTCH1 NOTCH3

1.49e-05378234854382
Pubmed

Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease.

NOTCH1 NOTCH3

1.49e-05378229767458
Pubmed

The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.

NOTCH1 NOTCH3

1.49e-0537827698746
Pubmed

Genetic Factors Involved in Mandibular Prognathism.

HSPG2 ALPL

1.49e-05378228570402
Pubmed

Hepatitis B virus X protein and hypoxia‑inducible factor-1α stimulate Notch gene expression in liver cancer cells.

NOTCH1 NOTCH3

1.49e-05378227840976
Pubmed

Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification.

ASXL1 RNF2

1.49e-05378229967380
Pubmed

MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.

MYT1 NOTCH1

1.49e-05378227705795
Pubmed

Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells.

NOTCH1 NOTCH3

1.49e-05378233664344
Pubmed

Jagged1 is essential for osteoblast development during maxillary ossification.

ACVR1 NOTCH1 ALPL

1.62e-052278324491691
Pubmed

Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.

ACVR1 NOTCH1 ALPL

2.12e-052478325382630
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH1 NOTCH3

2.97e-05478228061457
Pubmed

Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.

NOTCH1 NOTCH3

2.97e-05478221673954
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH1 NOTCH3

2.97e-05478224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH1 NOTCH3

2.97e-05478220069356
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH1 NOTCH3

2.97e-05478219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH1 NOTCH3

2.97e-05478228669409
Pubmed

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.

NOTCH1 NOTCH3

2.97e-05478210551863
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH1 NOTCH3

2.97e-05478211466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH1 NOTCH3

2.97e-05478224151014
Pubmed

Activation of Notch signaling in human tongue carcinoma.

NOTCH1 NOTCH3

2.97e-05478220819128
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH1 NOTCH3

2.97e-05478211401408
Pubmed

Novel MIR143-NOTCH fusions in benign and malignant glomus tumors.

NOTCH1 NOTCH3

2.97e-05478223999936
Pubmed

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

NOTCH1 NOTCH3

2.97e-05478229170450
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH1 NOTCH3

2.97e-05478210194420
Pubmed

NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.

NOTCH1 NOTCH3

2.97e-05478218156632
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH1 NOTCH3

2.97e-0547828898100
Pubmed

Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.

NOTCH1 NOTCH3

2.97e-05478211978185
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH1 NOTCH3

2.97e-05478211459941
Pubmed

Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions.

PLG ALPL

2.97e-05478228686706
Pubmed

The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1.

SASH1 NOTCH1

2.97e-05478228823832
Pubmed

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.

NOTCH1 NOTCH3

2.97e-05478212391150
Pubmed

Myt/NZF family transcription factors regulate neuronal differentiation of P19 cells.

MYT1L MYT1

2.97e-05478221540077
Pubmed

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

NOTCH1 NOTCH3

2.97e-05478220829372
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH1 NOTCH3

2.97e-05478218184405
Pubmed

CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.

NOTCH1 NOTCH3

2.97e-05478222705236
Pubmed

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.

NOTCH1 NOTCH3

2.97e-05478220040020
Pubmed

Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 (Cldn10) in Cytodifferentiation of Stratum Intermedium.

NOTCH1 ALPL

2.97e-05478233195274
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH1 NOTCH3

2.97e-05478215917835
Pubmed

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

NOTCH1 NOTCH3

2.97e-05478223444212
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH1 NOTCH3

2.97e-05478217920003
Pubmed

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.

NOTCH1 NOTCH3

2.97e-05478211044625
Pubmed

ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.

HSPG2 NOTCH1 NOTCH3

4.66e-053178322274697
Pubmed

Myt1 family recruits histone deacetylase to regulate neural transcription.

MYT1L MYT1

4.94e-05578215935060
Pubmed

Notch signaling in bulge stem cells is not required for selection of hair follicle fate.

NOTCH1 NOTCH3

4.94e-05578219211676
Pubmed

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

NOTCH1 NOTCH3

4.94e-05578227040987
Pubmed

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.

NOTCH1 NOTCH3

4.94e-05578211006133
Pubmed

Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

NOTCH1 NOTCH3

4.94e-05578221124806
Pubmed

Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.

HERC3 HERC2

4.94e-05578222124266
Pubmed

Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells.

NOTCH1 NOTCH3

4.94e-05578215879553
Pubmed

Functional diversity of notch family genes in fetal lung development.

NOTCH1 NOTCH3

4.94e-05578215064243
Pubmed

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

NOTCH1 NOTCH3

4.94e-05578221562564
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

NOTCH1 NOTCH3

4.94e-05578223675950
GeneFamilyZinc fingers C2H2C-type

MYT1L MYT1

2.43e-0535221261
GeneFamilyFibulins

FBLN7 HMCN2

2.25e-048522556
GeneFamilyWD repeat domain containing

WDR83 WDR18 WDR86 WDR26 SHKBP1

9.17e-04262525362
GeneFamilyProtein phosphatases, Mg2+/Mn2+ dependent

PPM1D PDP1

1.07e-0317522701
CoexpressionGSE11961_FOLLICULAR_BCELL_VS_PLASMA_CELL_DAY7_DN

PHF20 SLC20A1 PDP1 HMGXB4 HERC2 KMT2E WDR26

2.27e-06200787M9315
CoexpressionKANG_AR_TARGETS_DN

SLC20A1 SLC20A2 ALPL

2.00e-0518783MM892
CoexpressionKANG_AR_TARGETS_DN

SLC20A1 SLC20A2 ALPL

2.00e-0518783M2225
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

MYT1L PITPNM1 ZBTB46 TTC28 TNFRSF18 WDR86

4.56e-07167776b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 ZBTB46 HMCN2 SASH1 TTC28 NRN1

8.56e-07186776a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SASH1 SLC20A2 PDP1 SUN1 CRNN MUC4

1.27e-06199776a8f4bd0e65f36b29535864fae4347369d5c864d2
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-squamous_epithelial_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SASH1 SLC20A2 PDP1 SUN1 CRNN MUC4

1.27e-06199776eacea42e973f073b410f54c0a1b3a7f2dc2b5a29
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 ZBTB46 NRN1 NOTCH1 ALPL

9.39e-0616377573c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HSPG2 SASH1 TTC28 PPM1D NRN1

2.02e-0519177550601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCellCF-Epithelial|CF / Disease state, Lineage and Cell class

SASH1 PDP1 CRNN TTC22 MUC4

2.12e-05193775518901c2e36a79c6189cd0d9e6d36dbd4f56a79c
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 TTC28 KIF26A NOTCH1 PGM5

2.12e-05193775d485634c564b268e344b6a2863c26f6adaec9e38
ToppCellCF-Epithelial-Epithelial_cell|CF / Disease state, Lineage and Cell class

SASH1 PDP1 CRNN TTC22 MUC4

2.12e-051937754e3dda27c71b7fdac90d081f0d8e9ca3a8ea7820
ToppCellMesenchymal_cells-Arteriolar_fibro.|World / Lineage and Cell class

HSPG2 FBLN7 HMCN2 COMP ZIC1

2.17e-05194775c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

TTC28 MYT1 NHLH1 KMT2E NRN1

2.28e-0519677538da0751941adca650fe9b383d9f343153978eb5
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

TTC28 MYT1 NHLH1 KMT2E NRN1

2.28e-05196775721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-tip_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 SASH1 MPDZ NRN1 PGM5

2.34e-05197775b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCellMesenchymal_cells-Arteriolar_fibro.|Mesenchymal_cells / Lineage and Cell class

HSPG2 FBLN7 HMCN2 COMP ZIC1

2.34e-05197775cb321836980e7b4efbb9284c6af7ccd34079d2be
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SASH1 SLC20A2 PDP1 SUN1 MUC4

2.46e-051997755a1557fe35aa48080d4967e8724bf27f9585a5fb
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SASH1 SLC20A2 PDP1 SUN1 MUC4

2.46e-051997750a657475b92aa3a713da62da364525249fdc3886
ToppCell5'-Adult-LargeIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 SASH1 NRN1 PGM5 ALPL

2.46e-05199775ffebd99d55d31cf51b4878b2690ed0b9b3799223
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

FAM120A MPDZ NOTCH1 PGM1 NOTCH3

2.46e-05199775358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|367C / Donor, Lineage, Cell class and subclass (all cells)

MYT1L PITPNM1 TNFRSF18 ANKMY1

1.30e-04149774f18bddc84b064f3d57a1281d5172c404d87f25da
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

HSPG2 ZBTB46 TNFRSF18 WDR86

1.43e-04153774aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYT1L ARFGEF3 MYT1 UNC80

1.66e-041597747747cef94c55144fddcd024a7495318357f1351b
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

EPHB3 HERC6 KMT2E NRN1

1.66e-0415977418e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EPHB3 ARFGEF3 BPIFB2 CABLES1

1.74e-041617747c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

COMP TNFRSF18 WDR86 CABLES1

1.74e-041617743e5a125a25d55bf27652f456239b00b315d54d91
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DAGLB WDR86 TTC22 MYRF

1.96e-04166774545f6c91102568791443717e522f89cb3bd1a070
ToppCellClub_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

EPHB3 BPIFB2 MUC4 NOTCH3

2.01e-04167774dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP|Hippocampus / BrainAtlas - Mouse McCarroll V32

FBLN7 COMP WDR86 ZIC1

2.05e-0416877426aa96b2b547d11941cb803995ea3d302ee0518c
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

RNF2 TTC28 OAS3 NOTCH3

2.05e-04168774ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 HMCN2 KIF26A NRN1

2.10e-04169774c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF26A FBRSL1 HERC6 PGM5

2.25e-041727748a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCellIIH-CD8-naive_CD4|IIH / Condition, Cell_class and T cell subcluster

FBLN7 PDP1 ANKMY1 TOMM40

2.30e-041737744f2843371d18af766c1892529ce286f56c956fde
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

COMP SLC20A2 WDR86 ALPL

2.35e-04174774430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PITPNM1 SLC20A1 MUC4 NOTCH3

2.35e-04174774207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF26A GNPTAB NOTCH1 PGM5

2.40e-0417577443be63976da5ad0764d24d90919a77ce46068f52
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ASXL1 DCP1B TNFRSF18 TTC22

2.45e-04176774856a8c4211ea33d926b18d8959a03909562aa563
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 COMP NRN1 CABLES1

2.50e-041777746b4fe717928814dafcd13090b1c90ea973938c6d
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

KIF26A MYRF NOTCH3 ALPL

2.56e-041787748f31b3fac51591f7f2bcb898c07708b3e9f93a16
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

FBLN7 COMP WDR86 ZIC1

2.56e-04178774cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC20A1 SUN1 GOLGA6L9 MUC4

2.61e-041797746e965e424eebef50f0202cff75f458be395cfca1
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF628 WDR18 CD163 CABLES1

2.61e-041797742c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCellCOVID-19_Mild-NK_CD56bright|COVID-19_Mild / Disease condition and Cell class

TNFRSF18 SLC49A3 NOTCH1 CABLES1

2.61e-0417977490e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF628 WDR18 CD163 CABLES1

2.61e-041797746eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

NHSL1 SASH1 CD163 NOTCH3

2.67e-041807747be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 NRN1 UNC80 ZIC1

2.67e-04180774d76349ecef7c5878bf215e946f032264161eb61b
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 TTC28 KMT2E PGM5

2.67e-04180774dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCellIIH-CD8-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

SLC20A1 GNPTAB ANKMY1 TTC22

2.67e-04180774d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 TTC28 KMT2E PGM5

2.67e-04180774423454e3390080ae03bb3cbb267255ebfe4df080
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 TTC28 KIF26A PGM5

2.73e-04181774fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB3 HSPG2 FBLN7 COMP

2.90e-04184774d754c3de621429b220ae4ac426cdfc619e848462
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

HSPG2 HMCN2 SASH1 TTC28

2.90e-041847740f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1L ARFGEF3 UNC80 ZIC1

2.90e-041847747d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellILEUM-inflamed-(7)_Lymphatics|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SASH1 MPDZ NRN1 PGM5

2.96e-04185774d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCellMesenchymal_cells-Osteo-CAR|World / Lineage and Cell class

COMP SLC20A2 WDR86 ALPL

2.96e-0418577416f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell21-Trachea-Epithelial-Goblet-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

ARFGEF3 BPIFB2 ACVR1 ALPL

3.02e-04186774f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 HMCN2 KIF26A NRN1

3.02e-041867742e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 HMCN2 KIF26A NRN1

3.02e-04186774c3449e54454009973818fc1101933c6f0168258c
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYT1L ARFGEF3 MYT1 UNC80

3.02e-04186774b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

ARFGEF3 WDR86 MUC4 NOTCH3

3.09e-04187774ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SASH1 TTC28 TNFRSF18 ALPL

3.09e-04187774689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Tumor_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

HSPG2 MPDZ NRN1 PGM5

3.09e-041877742713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SASH1 TTC28 TNFRSF18 ALPL

3.09e-041877744527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.09e-04187774d9943e65eedab73d141eae524e2411653a751705
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.09e-041877747b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 KIF26A NRN1 ALPL

3.09e-04187774d9d10ed7c905778a29a0dc3ced3eef02a6b1de5c
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 NRN1 NOTCH1 ALPL

3.09e-0418777425efb82afe863a853ecdd781ad89026c993aaa67
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.15e-041887744ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.15e-04188774e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

ASXL1 PHF20 COMP NOTCH3

3.15e-0418877414bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 KIF26A NOTCH1 ALPL

3.21e-04189774db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1L ARFGEF3 KIF26A MYT1

3.21e-04189774cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1L ARFGEF3 KIF26A MYT1

3.28e-04190774bdbfaced785db79ff965f332759be258dbf743cf
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

ARFGEF3 WDR86 MUC4 NOTCH3

3.28e-04190774756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC17A5 FAM120A SLC49A3 CD163

3.28e-0419077463018acb7ad80415e861643162abdc2e55968ee4
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC4 NOTCH1 CD163 NOTCH3

3.28e-041907740bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 SASH1 MPDZ NRN1

3.28e-04190774141266bf411ea675fbf889b20c1b08673c45ff95
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CBR4 SLC20A2 PEX1 HERC3

3.28e-041907743f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARFGEF3 MYT1 NHLH1 UNC80

3.28e-04190774b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCellBL-critical-LOC-Epithelial-Squamous|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPHB3 SASH1 CRNN MUC4

3.34e-041917743f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1L ARFGEF3 MYT1 UNC80

3.41e-04192774d8f5df2c2a50e567f24ebecc8033ac97ba89d9c5
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

HSPG2 ZBTB46 SASH1 TTC28

3.41e-0419277427ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CBR4 SLC20A2 PEX1 HERC3

3.41e-04192774c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1L ARFGEF3 MYT1 UNC80

3.48e-041937749661ea0ee7273928c7de2a9f49e853595fa77699
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 TTC28 NOTCH1 PGM5

3.48e-04193774826b8dd801298b3e0cd76232feae5a14026b8806
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 TTC28 NOTCH1 PGM5

3.48e-0419377487d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1L ARFGEF3 KIF26A MYT1

3.48e-041937748851275bcf4ecd6e87a91c8784fc5d76d246ff3b
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.55e-04194774c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 ZBTB46 HMCN2 TTC28

3.62e-041957746bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYT1L HMCN2 UNC80 ALPL

3.62e-04195774d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 TTC28 MUC4 UNC80

3.62e-04195774bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYT1L HMCN2 UNC80 ALPL

3.62e-0419577419853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.62e-04195774df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HSPG2 SASH1 TTC28 NRN1

3.62e-04195774023e3c97dd3696d74f002ff8da0c04d876c82aef
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 NRN1 NOTCH1 ALPL

3.69e-04196774ae46d4b00be92e64e46252dcc156161b171eded4
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

HSPG2 ZBTB46 SASH1 PGM5

3.69e-04196774e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 HMCN2 NRN1 NOTCH1

3.69e-04196774a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellBronchial-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIF26A MYT1 NRN1 UNC80

3.69e-04196774a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN7 HMCN2 COMP NOTCH3

3.69e-04196774614a07334707eafe238d5cb7b080a3ca796a1920
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP ACVR1 NOTCH1 PGM5

3.69e-04196774e386526332138e636aef2542c11316347a45689c
ToppCellBronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DAGLB ZBTB46 OAS3 CD163

3.69e-041967748862964090f9a679a548103bfbb12e91295aae62
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1L ARFGEF3 KIF26A MYT1

3.76e-04197774fd43fc1cbf0c17b370397d73dddc572565a759c7
DiseaseBicuspid aortic valve

HMCN2 MUC4

1.91e-053752HP_0001647
Diseaseprimary angle-closure glaucoma (is_implicated_in)

ACVR1 MYRF

1.91e-053752DOID:1405 (is_implicated_in)
DiseaseAortic valve calcification

SLC20A1 NOTCH1

1.33e-047752C0428791
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH3

1.33e-047752DOID:299 (implicated_via_orthology)
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH3

1.33e-047752DOID:3620 (implicated_via_orthology)
DiseaseCalcinosis

SLC20A2 NOTCH1 ALPL

1.69e-0442753C0006663
DiseaseMicrocalcification

SLC20A2 NOTCH1 ALPL

1.69e-0442753C0521174
DiseaseTumoral calcinosis

SLC20A2 NOTCH1 ALPL

1.69e-0442753C0263628
Diseasewaist-hip ratio, high density lipoprotein cholesterol measurement

DAGLB TOMM40

2.83e-0410752EFO_0004343, EFO_0004612
DiseaseConnective Tissue Diseases

ACVR1 NOTCH1

4.88e-0413752C0009782
Diseasetriglycerides to total lipids in medium VLDL percentage

TOMM40 PLG MYRF

5.61e-0463753EFO_0022335
Diseasecholesterol to total lipids in medium VLDL percentage

TOMM40 PLG MYRF

5.61e-0463753EFO_0022239
DiseaseMetabolic Bone Disorder

SLC20A1 ALPL

5.69e-0414752C0005944
Diseasecholesteryl esters to total lipids in medium VLDL percentage

TOMM40 PLG MYRF

5.88e-0464753EFO_0022253
DiseaseOsteopenia

SLC20A1 ALPL

6.55e-0415752C0029453
Diseasefatty liver disease (is_marker_for)

CD163 ALPL

8.46e-0417752DOID:9452 (is_marker_for)
Diseasefree cholesterol to total lipids in large LDL percentage

TOMM40 PLG MYRF

8.98e-0474753EFO_0022280
Diseaseosteochondrodysplasia (is_implicated_in)

HSPG2 COMP

1.06e-0319752DOID:2256 (is_implicated_in)
Diseasep-tau:beta-amyloid 1-42 ratio measurement

TTC28 TOMM40

1.06e-0319752EFO_0007709
Diseasealcohol drinking

OAS3 KMT2E PGM1

1.17e-0381753EFO_0004329
Diseaseerosive tooth wear measurement

MYT1L KIF26A PLG

1.58e-0390753EFO_0009331
DiseaseCarcinoma, Pancreatic Ductal

NOTCH1 NOTCH3

1.70e-0324752C0887833
DiseaseNeurodevelopmental Disorders

MYT1L PPM1D KMT2E

1.74e-0393753C1535926
DiseaseCerebral Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0750935
DiseaseIntracranial Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0750936
DiseasePilocytic Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0334583
DiseaseAstrocytoma

ACVR1 NOTCH1

1.84e-0325752C0004114
DiseaseJuvenile Pilocytic Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0280783
DiseaseDiffuse Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0280785
Diseaseresponse to gemcitabine

MCPH1 DCP1B

1.84e-0325752GO_0036272
DiseaseGrade I Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C1704230
DiseaseSubependymal Giant Cell Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0205768
DiseaseMixed oligoastrocytoma

ACVR1 NOTCH1

1.84e-0325752C0547065
DiseaseChildhood Cerebral Astrocytoma

ACVR1 NOTCH1

1.84e-0325752C0338070
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH3

1.99e-0326752DOID:1319 (implicated_via_orthology)
DiseaseGemistocytic astrocytoma

ACVR1 NOTCH1

1.99e-0326752C0334581
DiseaseProtoplasmic astrocytoma

ACVR1 NOTCH1

1.99e-0326752C0334580
DiseaseFibrillary Astrocytoma

ACVR1 NOTCH1

1.99e-0326752C0334582
DiseaseAnaplastic astrocytoma

ACVR1 NOTCH1

2.15e-0327752C0334579
DiseaseSeizures

MPDZ KMT2E NOTCH3 ALPL

2.34e-03218754C0036572
Diseasecerebral infarction (is_implicated_in)

TOMM40 MYRF

2.48e-0329752DOID:3526 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ASLGAFAGHSQAAAN

FBRSL1

316

Q9HCM7
AGCLGSHSRDSDLGA

CCDC116

166

Q8IYX3
AGFTGNGSHCTDVNE

COMP

116

P49747
ADLLDHSCTSGSGSG

ACVR1

181

Q04771
GAHVESASGFSGCHA

ASXL1

181

Q8IXJ9
SASGFSGCHADGESG

ASXL1

186

Q8IXJ9
LSLCGEESFGTGSDH

PGM1

371

P36871
AAGQAAHTCFLDTDG

HSPG2

1216

P98160
CNLCGEESFGTGSDH

PGM5

376

Q15124
SCEAGFHLSGAAGDS

FBLN7

206

Q53RD9
LTGDGRHCAALGSSF

MUC4

5101

Q99102
CHNGGSCTDGINTAF

NOTCH1

916

P46531
LHSSFDDLCGNSGCG

MCPH1

231

Q8NEM0
LSCGFDAGDCGQDHF

GNPTAB

526

Q3T906
VAAGGAHSACVTAAG

HERC2

4096

O95714
HAGTEAATAAARCGS

MTO1

46

Q9Y2Z2
AAGGAHSFALSLSGA

HERC3

196

Q15034
AGHYLCLASNSAGSD

HMCN2

3751

Q8NDA2
HGSGNLCNSSDGFGN

NHSL1

621

Q5SYE7
GSEGGSATGESACHF

PCDH8

851

O95206
VAAGGAHSFALSLCG

HERC6

186

Q8IVU3
HNGGTCFNTLGGHSC

NOTCH3

286

Q9UM47
PHASGSLSNNGDGCA

KMT2E

1186

Q8IZD2
GSSDFFCTGSGLGCH

LMLN2

451

A0A1B0GTW7
HGAGGASACSRCDDN

EPHB3

381

P54753
SVVSGADGCIFSFGH

KIF26A

456

Q9ULI4
SLFELCGSGNGAAGS

NRN1

106

Q9NPD7
TGEAAGGAGEAACHS

GOLGA6L4

546

A6NEF3
GGAGEAACHSFRAAE

GOLGA6L4

551

A6NEF3
EAAGGAGEAACHSFR

GOLGA6L9

406

A6NEM1
RVAAASGHCGAFSGS

FAM120A

911

Q9NZB2
SSVAFFAVCDGHGGR

PPM1D

96

O15297
GCGSDASQFAESHSA

HMGXB4

266

Q9UGU5
GVFDGHAGCACSQAV

PDP1

141

Q9P0J1
ACGSQESGSLHSGAS

CRNN

96

Q9UBG3
HGTFGAAACSIGFAV

POP5

41

Q969H6
GANLGHCAPASSAGS

ALPL

491

P05186
CENGSTHSAGEFFTG

DCP1B

316

Q8IZD4
HSETESGFSDCGGGA

NHLH1

16

Q02575
AACSSGSAGTDAAGA

CABLES1

11

Q8TDN4
EEGASGRFGCCSAAH

DAGLB

601

Q8NCG7
LGCFHSGTESFSGEG

ARFGEF3

1626

Q5TH69
AAAGDLGGDHLAFSC

CBR4

41

Q8N4T8
SGSHEGGHFQDTGQC

ANKMY1

406

Q9P2S6
GCGEAINATGSAHFG

CD163

761

Q86VB7
TLGGFCSSGFSINHL

SLC17A5

401

Q9NRA2
LTACFGSFAHGGNDV

SLC20A1

521

Q8WUM9
CFGSFAHGGNDVSNA

SLC20A2

496

Q08357
FLNHSSGSDDSAGDG

PEX1

1086

O43933
NGSGAEDNGDSSHCS

RNF2

166

Q99496
LNSGCQGGEHAACFT

OAS3

171

Q9Y6K5
SALTCHSFGDGSGAA

PHF20

381

Q9BVI0
AQGAGLESHGGSTFC

PGGT1B

211

P53609
LNSGSHFCGGSLISE

PRSS3P2

41

Q8NHM4
ALESADGHGGCSAGN

SHKBP1

481

Q8TBC3
CLQFTGDSSHFISGG

WDR18

126

Q9BV38
AGHLAGGTDSCQGDS

PLG

746

P00747
ACSLFSGHANEFDGS

BPIFB2

136

Q8N4F0
EQILCASGHSSGFSG

SLC49A3

271

Q6UXD7
GFDALCHSANAGTGS

PITPNM1

571

O00562
ISGCHRGNSFDGSLS

UNC80

286

Q8N2C7
SLHGSSCGDGLNYGS

MPDZ

861

O75970
DAHSGGCSADAYSGG

RBMXL3

561

Q8N7X1
GCSADAYSGGHDSSS

RBMXL3

566

Q8N7X1
CADCGKGFGHASSLS

ZNF747

211

Q9BV97
QAGAAHTCSDCGHSF

ZNF646

816

O15015
SHGRTCSFGGFDLTN

SASH1

401

O94885
SFDNSSLCSGGGDKA

WDR83

76

Q9BRX9
GSGISCGNAQSDAAH

PRKRA

286

O75569
ATASASGAAEDGACG

TOMM40

61

O96008
QCIDCASGTFSGGHE

TNFRSF18

111

Q9Y5U5
GFGDAAAAASAQHSL

ZIC1

106

Q15915
TGECRAHGNLGSAFF

TTC28

271

Q96AY4
DVGAAAATAHNGFSC

SUN1

171

O94901
SCFGGHNEDFIASGS

WDR26

576

Q9H7D7
LDDAGSSHTDGFGCL

TTC22

461

Q5TAA0
GSGDACARAFDAQSG

WDR86

291

Q86TI4
SGDSAIASCHDGGSS

ZBTB46

181

Q86UZ6
HSHGAAGGQAFRCGS

ZNF628

376

Q5EBL2
SGAFSHAGSQFSRAG

MYRF

721

Q9Y2G1
GCDGSGHVSGSFLTH

MYT1L

1011

Q9UL68
CDGSGHANGSFLTHR

MYT1

951

Q01538