Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine kinase activity	ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	2.64e-06	363	193	15	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 EEF2K RAF1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	7.39e-06	446	193	16	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 EEF2K RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	7.70e-05	600	193	17	GO:0004672
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	RIPK2 MAP3K3 TAOK2 RAF1	1.25e-04	27	193	4	GO:0004709
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	GALK1 ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 EEF2K RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	1.87e-04	709	193	18	GO:0016773
GeneOntologyMolecularFunction	odorant binding	OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14	2.38e-04	127	193	7	GO:0005549
GeneOntologyMolecularFunction	olfactory receptor activity	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14 OR10A3 OR51Q1 OR10A6	3.01e-04	431	193	13	GO:0004984
GeneOntologyMolecularFunction	kinase activity	GALK1 ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 EEF2K RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	4.59e-04	764	193	18	GO:0016301
GeneOntologyMolecularFunction	brain-derived neurotrophic factor binding	A2M HAP1	5.51e-04	4	193	2	GO:0048403
GeneOntologyMolecularFunction	triplex DNA binding	DDX11 DDX12P	5.51e-04	4	193	2	GO:0045142
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	GALK1 GALT ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 UGP2 EEF2K RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	7.83e-04	938	193	20	GO:0016772
GeneOntologyMolecularFunction	POZ domain binding	ATXN1 ZBTB21	9.12e-04	5	193	2	GO:0031208
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	TDRD9 DDX11 DDX12P DHX30 SNRNP200	1.07e-03	80	193	5	GO:0008186
Domain	S_TKc	NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	2.18e-05	359	192	14	SM00220
Domain	Pkinase	NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	4.17e-05	381	192	14	PF00069
Domain	Kinase-like_dom	ATR NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 EEF2K RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	4.67e-05	542	192	17	IPR011009
Domain	PROTEIN_KINASE_ATP	NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	8.38e-05	459	192	15	PS00107
Domain	Ser/Thr_kinase_AS	RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	8.63e-05	357	192	13	IPR008271
Domain	PROTEIN_KINASE_ST	RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	9.92e-05	362	192	13	PS00108
Domain	Med12	MED12L MED12	1.05e-04	2	192	2	PF09497
Domain	Mediator_Med12_catenin-bd	MED12L MED12	1.05e-04	2	192	2	IPR021989
Domain	Med12-PQL	MED12L MED12	1.05e-04	2	192	2	PF12144
Domain	Med12-LCEWAV	MED12L MED12	1.05e-04	2	192	2	PF12145
Domain	Med12	MED12L MED12	1.05e-04	2	192	2	SM01281
Domain	Mediator_Med12	MED12L MED12	1.05e-04	2	192	2	IPR019035
Domain	Mediator_Med12_LCEWAV	MED12L MED12	1.05e-04	2	192	2	IPR021990
Domain	ARM-like	ATR NEK10 MROH5 PSME4 NCAPD2 UTP20 GCN1 MED12 ELMO3 LTN1 PUM1	1.15e-04	270	192	11	IPR011989
Domain	IPT	NFATC1 NFKB1 EBF3 EBF1	1.58e-04	27	192	4	SM00429
Domain	Prot_kinase_dom	NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	1.68e-04	489	192	15	IPR000719
Domain	PROTEIN_KINASE_DOM	NEK10 RPS6KB1 RIPK2 OBSCN MAP3K3 TAOK2 RAF1 DDR1 RIPK3 CAMK1D HIPK2 LATS1 PRKCD PRKCQ MAPK6	1.84e-04	493	192	15	PS50011
Domain	Olfact_rcpt	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14 OR10A3 OR51Q1 OR10A6	2.23e-04	393	192	13	IPR000725
Domain	TIG	NFATC1 NFKB1 EBF3 EBF1	2.74e-04	31	192	4	PF01833
Domain	IPT	NFATC1 NFKB1 EBF3 EBF1	3.11e-04	32	192	4	IPR002909
Domain	KINESIN_LIGHT	KLC1 KLC2	3.13e-04	3	192	2	PS01160
Domain	Kinesin_light_repeat	KLC1 KLC2	3.13e-04	3	192	2	IPR015792
Domain	-	ATR NEK10 MROH5 PSME4 NCAPD2 UTP20 GCN1 MED12 PUM1	4.98e-04	222	192	9	1.25.10.10
Domain	Pkinase_C	RPS6KB1 LATS1 PRKCD PRKCQ	5.48e-04	37	192	4	IPR017892
Domain	Kinesin_light	KLC1 KLC2	6.22e-04	4	192	2	IPR002151
Domain	Prot_kin_PKC_delta	PRKCD PRKCQ	6.22e-04	4	192	2	IPR014376
Domain	COE	EBF3 EBF1	6.22e-04	4	192	2	PS01345
Domain	Transcription_factor_COE	EBF3 EBF1	6.22e-04	4	192	2	IPR003523
Domain	COE_HLH	EBF3 EBF1	6.22e-04	4	192	2	IPR032201
Domain	COE_DBD	EBF3 EBF1	6.22e-04	4	192	2	IPR032200
Domain	Transcription_factor_COE_CS	EBF3 EBF1	6.22e-04	4	192	2	IPR018350
Domain	COE1_HLH	EBF3 EBF1	6.22e-04	4	192	2	PF16423
Domain	COE1_DBD	EBF3 EBF1	6.22e-04	4	192	2	PF16422
Domain	TPR-like_helical_dom	ADCY10 ATR SRP72 PRMT9 EEF2K CFAP70 KLC1 CNOT10 KLC2	7.04e-04	233	192	9	IPR011990
Domain	Ig_E-set	A2M NFATC1 NFKB1 EBF3 EBF1 SNRNP200	7.19e-04	104	192	6	IPR014756
Domain	ARM-type_fold	ATR NEK10 MROH5 PSME4 NCAPD2 UTP20 GCN1 RNPEPL1 ELMO3 LTN1 PUM1	7.93e-04	339	192	11	IPR016024
Domain	Pkinase_C	RPS6KB1 LATS1 PRKCD PRKCQ	8.93e-04	42	192	4	PF00433
Domain	DAG/PE-bd	RAF1 PRKCD PRKCQ	1.24e-03	21	192	3	IPR020454
Domain	-	ADCY10 ATR SRP72 PRMT9 CFAP70 KLC1 CNOT10 KLC2	1.38e-03	207	192	8	1.25.40.10
Domain	HEAT	ATR NCAPD2 UTP20 GCN1	1.48e-03	48	192	4	PF02985
Domain	Rab5-bind	KLC1 KLC2	1.53e-03	6	192	2	PF09311
Domain	Rabaptin_Rab5-bd_dom	KLC1 KLC2	1.53e-03	6	192	2	IPR015390
Domain	TPR_10	KLC1 KLC2	1.53e-03	6	192	2	PF13374
Domain	Pentatricopeptide_repeat	MRPS27 KLC1 KLC2	1.63e-03	23	192	3	IPR002885
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR10A3 OR10A6	6.71e-06	70	143	7	MM14984
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	A2M GALK1 MRPS27 PSMD8 PGD HNRNPL GANAB PRMT9 BOP1 GCN1 SLC27A3 RAF1 RBBP7 DTNA MTHFD1L SHMT2 AMBRA1 CPD CPT1A LTN1 EDEM1 SNRNP200	4.62e-08	974	198	22	28675297
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14 OR10A3 OR51Q1 OR10A6	9.04e-08	340	198	13	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14 OR10A3 OR51Q1 OR10A6	9.04e-08	340	198	13	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14 OR10A3 OR51Q1 OR10A6	1.00e-07	343	198	13	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1A2 OR2AT4 OR1A1 OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14 OR10A3 OR51Q1 OR10A6	1.11e-07	346	198	13	14611657
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OBSCN ATG2A FHIP1B TAOK2 FZD1 TBC1D16 PSME4 NFATC1 PLEKHM2 NCAPD2 MFN2 GCN1 MED12 CREB3 MTHFD1L RNPEPL1 AMBRA1 FAM83H DHX30 RADIL PUM1 RASD2	4.00e-07	1105	198	22	35748872
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	RPS6KB1 PKD1L1 ATG2A FHIP1B LRP1B GANAB NFKB1 PIH1D1 KLC1 MTHFD1L ITSN1 KLC2 SHMT2 CPD FAM83H GLMN LATS1 DPH5 SNX18	4.96e-07	853	198	19	28718761
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	PKD1L1 OBSCN SRP72 MAP3K3 TAOK2 IVD TBC1D16 BNC1 NCAPD2 DDR1 SFRP2 RBBP7 HIPK2 KLC2 SHMT2 FAM83H RADIL AP5B1 LTN1 SNX18 TENM1 EDEM1 PUM1	5.13e-07	1215	198	23	15146197
Pubmed	A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.	KLF12 KLF5 NR5A2	1.80e-06	5	198	3	20101243
Pubmed	Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain.	RIPK2 NFKB1 RIPK3	1.80e-06	5	198	3	27045108
Pubmed	Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.	GALK1 GANAB GCN1 MTHFD1L AMBRA1 CPD HIF1AN ASS1 ASB2	2.22e-06	198	198	9	24337577
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ATR RPS6KB1 RIPK2 PEX1 MAP3K3 BOP1 PCDH18 KLC1 RAF1 DDR1 RBBP7 DTNA HIPK2 FAM83H LATS1 RTL1 PRKCD MAPK6	5.25e-06	910	198	18	36736316
Pubmed	14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.	RAF1 PRKCD PRKCQ	6.25e-06	7	198	3	10433554
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR1A1 OR5K1 OR5H1 OR5H15 OR5H14	6.45e-06	46	198	5	32126975
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	OBSCN BCAT2 PGD HNRNPL GANAB PSME4 SLC12A9 ATXN1 KLF5 UGP2 PIH1D1 CAMK1D RBBP7 HIPK2 EBF1 HIF1AN WASH3P WASH2P PUM1	6.79e-06	1021	198	19	26760575
Pubmed	SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.	NFATC1 NFKB1 PRKCQ	9.97e-06	8	198	3	15539155
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	A2M PGD HNRNPL HMG20A RBBP7 PRKCD SNRNP200	1.07e-05	131	198	7	34551306
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	XYLT1 KL GLMN FRY	1.38e-05	26	198	4	33905568
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PSME4 PIH1D1 TASOR UBR2 CPT1A HIF1AN TRMT6 LTN1	3.15e-05	212	198	8	33853758
Pubmed	Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease.	KL FGF23	3.22e-05	2	198	2	21852584
Pubmed	Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres.	OBSCN ANK1	3.22e-05	2	198	2	19002483
Pubmed	FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.	KL FGF23	3.22e-05	2	198	2	33257569
Pubmed	Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+.	RAF1 PRKCD	3.22e-05	2	198	2	11171046
Pubmed	Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.	KL FGF23	3.22e-05	2	198	2	20466874
Pubmed	Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL.	PRKCD PRKCQ	3.22e-05	2	198	2	17548619
Pubmed	Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury.	KL FGF23	3.22e-05	2	198	2	33220250
Pubmed	FGF23 induces left ventricular hypertrophy.	KL FGF23	3.22e-05	2	198	2	21985788
Pubmed	Fibroblast growth factor 23-Klotho and mineral metabolism in the first year after pediatric kidney transplantation: A single-center prospective study.	KL FGF23	3.22e-05	2	198	2	36471536
Pubmed	Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children.	KL FGF23	3.22e-05	2	198	2	27017221
Pubmed	NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.	MAP3K3 NFKB1	3.22e-05	2	198	2	15047705
Pubmed	Fibroblast Growth Factor 23 and α-Klotho Protein Are Associated with Adverse Clinical Outcomes in Non-Dialysis CKD Patients.	KL FGF23	3.22e-05	2	198	2	33040068
Pubmed	Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy.	KL FGF23	3.22e-05	2	198	2	27999806
Pubmed	Induction of RIP-2 kinase by proinflammatory cytokines is mediated via NF-kappaB signaling pathways and involves a novel feed-forward regulatory mechanism.	RIPK2 NFKB1	3.22e-05	2	198	2	19693652
Pubmed	A biophysical characterisation of factors controlling dimerisation and selectivity in the NF-kappaB and NFAT families.	NFATC1 NFKB1	3.22e-05	2	198	2	15178248
Pubmed	Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta.	NFATC1 PRKCQ	3.22e-05	2	198	2	11222731
Pubmed	A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy.	KL FGF23	3.22e-05	2	198	2	32527977
Pubmed	Ultraviolet B Radiation Stimulates the Interaction between Nuclear Factor of Activated T Cells 5 (NFAT5) and Nuclear Factor-Kappa B (NF-κB) in Human Lens Epithelial Cells.	NFATC1 NFKB1	3.22e-05	2	198	2	28632030
Pubmed	The role of Klotho and FGF23 in cardiovascular outcomes of diabetic patients with chronic limb threatening ischemia: a prospective study.	KL FGF23	3.22e-05	2	198	2	37061530
Pubmed	Obscurin is a ligand for small ankyrin 1 in skeletal muscle.	OBSCN ANK1	3.22e-05	2	198	2	12631729
Pubmed	Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells.	NFKB1 RIPK3	3.22e-05	2	198	2	34498705
Pubmed	Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status.	KL FGF23	3.22e-05	2	198	2	20685863
Pubmed	Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement.	NFATC1 NFKB1	3.22e-05	2	198	2	16237100
Pubmed	Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype.	KL FGF23	3.22e-05	2	198	2	18984852
Pubmed	FGF23 and klotho at the intersection of kidney and cardiovascular disease.	KL FGF23	3.22e-05	2	198	2	37443358
Pubmed	Influence of FGF23 and Klotho on male reproduction: Systemic vs direct effects.	KL FGF23	3.22e-05	2	198	2	32729975
Pubmed	Fibroblast growth factor 23 and Klotho contribute to airway inflammation.	KL FGF23	3.22e-05	2	198	2	29748308
Pubmed	Fibroblast growth factor 23 and Klotho serum levels in healthy children.	KL FGF23	3.22e-05	2	198	2	24880094
Pubmed	Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.	KL FGF23	3.22e-05	2	198	2	24991914
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	3.22e-05	2	198	2	34910522
Pubmed	Gender Specific Association between Serum Fibroblast Growth Factor 23/α-Klotho and Coronary Artery and Aortic Valve Calcification.	KL FGF23	3.22e-05	2	198	2	26279337
Pubmed	Cardiovascular remodeling as a result of fibroblast growth factor-23 (FGF-23)/Klotho imbalance in patients with CKD.	KL FGF23	3.22e-05	2	198	2	34718928
Pubmed	Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.	KLC1 KLC2	3.22e-05	2	198	2	22470497
Pubmed	Up-regulation of FGF23 release by aldosterone.	NFKB1 FGF23	3.22e-05	2	198	2	26773502
Pubmed	Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.	CADM1 NFATC1	3.22e-05	2	198	2	28414795
Pubmed	The Relationship Between Serum Fibroblast Growth Factor 23 and Klotho Protein and Low Bone Mineral Density in Middle-Aged and Elderly Patients with End-Stage Renal Disease.	KL FGF23	3.22e-05	2	198	2	37875141
Pubmed	NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells.	NFATC1 NFKB1	3.22e-05	2	198	2	37347664
Pubmed	α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells.	KL FGF23	3.22e-05	2	198	2	28463984
Pubmed	Mapping the binding site on small ankyrin 1 for obscurin.	OBSCN ANK1	3.22e-05	2	198	2	17720975
Pubmed	Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.	DDX11 DDX12P	3.22e-05	2	198	2	8833153
Pubmed	FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.	KL FGF23	3.22e-05	2	198	2	31801907
Pubmed	[Fibroblast growth factor 23/Klotho system in the context of cardiovascular damage].	KL FGF23	3.22e-05	2	198	2	23337450
Pubmed	Fibroblast Growth Factor 23 (FGF23) and Klotho Protein in Beta-Thalassemia.	KL FGF23	3.22e-05	2	198	2	32215890
Pubmed	Identification of new DNA markers of endometrial cancer in patients from the Ukrainian population.	NFKB1 DDR1	3.22e-05	2	198	2	17704737
Pubmed	Parathyroid function in chronic kidney disease: role of FGF23-Klotho axis.	KL FGF23	3.22e-05	2	198	2	23652554
Pubmed	Osteo-renal cross-talk and phosphate metabolism by the FGF23-Klotho system.	KL FGF23	3.22e-05	2	198	2	23652546
Pubmed	Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.	OR1A2 OR1A1	3.22e-05	2	198	2	17601748
Pubmed	Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus.	KL FGF23	3.22e-05	2	198	2	38622690
Pubmed	Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate.	KL FGF23	3.22e-05	2	198	2	25475745
Pubmed	Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system.	KL FGF23	3.22e-05	2	198	2	21406293
Pubmed	T-cell activation leads to poor activation of the HIV-1 clade E long terminal repeat and weak association of nuclear factor-kappaB and NFAT with its enhancer region.	NFATC1 NFKB1	3.22e-05	2	198	2	15466412
Pubmed	Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.	NFKB1 RNF213	3.22e-05	2	198	2	32139119
Pubmed	[Fibroblast Growth Factor 23-Klotho: a new axis of phosphate balance control].	KL FGF23	3.22e-05	2	198	2	19480830
Pubmed	Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in Chronic Kidney Disease: A systematic review with meta-analysis.	KL FGF23	3.22e-05	2	198	2	38169578
Pubmed	Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.	KL FGF23	3.22e-05	2	198	2	24348262
Pubmed	Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism.	KL FGF23	3.22e-05	2	198	2	23774819
Pubmed	[Regulation of calcium homeostasis by α-Klotho and FGF23].	KL FGF23	3.22e-05	2	198	2	21037388
Pubmed	[Discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis].	KL FGF23	3.22e-05	2	198	2	18591743
Pubmed	Plasmatic Klotho and FGF23 Levels as Biomarkers of CKD-Associated Cardiac Disease in Type 2 Diabetic Patients.	KL FGF23	3.22e-05	2	198	2	30934737
Pubmed	Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics.	KL FGF23	3.22e-05	2	198	2	28651327
Pubmed	Delayed activation of PKCdelta and NFkappaB and higher radioprotection in splenic lymphocytes by copper (II)-Curcumin (1:1) complex as compared to curcumin.	NFKB1 PRKCD	3.22e-05	2	198	2	17471506
Pubmed	Klotho expression in long bones regulates FGF23 production during renal failure.	KL FGF23	3.22e-05	2	198	2	28183805
Pubmed	Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.	KLC1 KLC2	3.22e-05	2	198	2	29036226
Pubmed	FGF23 and Klotho in relation to markers of endothelial dysfunction in kidney transplant recipients.	KL FGF23	3.22e-05	2	198	2	25380886
Pubmed	Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?	KL FGF23	3.22e-05	2	198	2	18528324
Pubmed	Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23.	KL FGF23	3.22e-05	2	198	2	22492635
Pubmed	Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.	KL NFKB1	3.22e-05	2	198	2	21389697
Pubmed	Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy.	KL FGF23	3.22e-05	2	198	2	33385780
Pubmed	Mechanism of the Fibroblast Growth Factor 23/α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer's Disease.	KL FGF23	3.22e-05	2	198	2	34503373
Pubmed	Serum α-Klotho and fibroblast growth factor 23 levels are not associated with non-proliferative diabetic retinopathy in type 1 diabetes mellitus.	KL FGF23	3.22e-05	2	198	2	38374169
Pubmed	Association between circulating FGF23, α-Klotho, and left ventricular diastolic dysfunction among patients with preserved ejection fraction.	KL FGF23	3.22e-05	2	198	2	25223536
Pubmed	Fibroblast growth factor 23 and soluble Klotho in patients with autosomal dominant polycystic kidney disease.	KL FGF23	3.22e-05	2	198	2	27450645
Pubmed	Correlation of serum levels of fibroblast growth factor 23 and Klotho protein levels with bone mineral density in maintenance hemodialysis patients.	KL FGF23	3.22e-05	2	198	2	29665846
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	3.22e-05	2	198	2	11687802
Pubmed	Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease.	KL FGF23	3.22e-05	2	198	2	23180879
Pubmed	FGF23, klotho and vitamin D interactions: What have we learned from in vivo mouse genetics studies?	KL FGF23	3.22e-05	2	198	2	22396163
Pubmed	FGF23-Klotho Axis and Fractures in Patients Without and With Early CKD: A Case-Cohort Analysis of CARTaGENE.	KL FGF23	3.22e-05	2	198	2	35139204
Pubmed	Association of serum levels of FGF23 and α-Klotho with glomerular filtration rate and proteinuria among cardiac patients.	KL FGF23	3.22e-05	2	198	2	25200959
Pubmed	[Significance of the morphogenetic proteins FGF-23 and Klotho as predictors of prognosis of chronic kidney disease].	KL FGF23	3.22e-05	2	198	2	24864466
Pubmed	Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies.	KL FGF23	3.22e-05	2	198	2	38459119
Pubmed	Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway.	KL FGF23	3.22e-05	2	198	2	37704925
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5K2 OR5K1 OR5H1 GPR15 OR5K3 OR5H15 OR5H14	3.72e-09	54	198	7	chr3q11
Cytoband	3q12.1	OR5K3 OR5H15 OR5H14	9.92e-05	21	198	3	3q12.1
Cytoband	3q11.2	OR5K2 OR5K1 OR5H1	1.91e-04	26	198	3	3q11.2
GeneFamily	Olfactory receptors, family 5	OR5K2 OR5K1 OR5H1 OR5K3 OR5T2 OR5H15 OR5H14	1.33e-05	112	126	7	152
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K3 TAOK2 RAF1	6.01e-04	24	126	3	654
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SRP72 CFAP70 KLC1 CNOT10 KLC2	1.26e-03	115	126	5	769
GeneFamily	Ankyrin repeat domain containing	ANKS1B NFKB1 ANK1 ANKRD44 ANKRA2 ANKEF1 ASB2	1.55e-03	242	126	7	403
GeneFamily	Cyclins\|Mediator complex	MED12L MED27 MED12	1.55e-03	33	126	3	1061
GeneFamily	C2 domain containing protein kinases	PRKCD PRKCQ	2.09e-03	10	126	2	835
GeneFamily	X-linked mental retardation\|RNA helicases	HELQ SNRNP200	2.54e-03	11	126	2	1168
Coexpression	MATSUDA_NATURAL_KILLER_DIFFERENTIATION	GALK1 B3GNT5 FHIP1B SESN1 BNC1 CADM1 ZBTB21 NCAPD2 DNAH8 SFRP2 RIPK3 ITSN1 SHMT2 CPD EBF1 DPH5	6.59e-07	486	192	16	M18517
Coexpression	MATSUDA_NATURAL_KILLER_DIFFERENTIATION	GALK1 B3GNT5 FHIP1B SESN1 BNC1 CADM1 ZBTB21 NCAPD2 DNAH8 SFRP2 RIPK3 ITSN1 SHMT2 CPD EBF1 DPH5	1.59e-06	520	192	16	MM1008
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA8 PCDH18 SFRP2 FMOD CILP EBF3 EBF1 RADIL CLMP	7.82e-08	172	197	9	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	droplet-Marrow-BM-1m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALK1 WDR46 DHODH RIPK3 MTHFD1L SHMT2 DPH5 ASS1 PUS7L	1.75e-07	189	197	9	b81540e097e95158851e07bfd78640ed6e64c2cf
ToppCell	droplet-Marrow-BM-1m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALK1 WDR46 DHODH RIPK3 MTHFD1L SHMT2 DPH5 ASS1 PUS7L	1.75e-07	189	197	9	0fda1a3f1e87fadf5309c8267beaa4501983b1dd
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRP1B ABCA8 PCDH18 FMOD CILP EBF3 ASS1 PRICKLE2 CLMP	2.48e-07	197	197	9	3bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRP1B ABCA8 PCDH18 FMOD CILP EBF3 ASS1 PRICKLE2 CLMP	2.48e-07	197	197	9	17344464fdcc5ba0c03959696b97c195f11e644c
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRP1B ABCA8 PCDH18 FMOD CILP EBF3 ASS1 PRICKLE2 CLMP	2.48e-07	197	197	9	5b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY10 ANKS1B F5 LRP1B USH2A USP26 TENM1 ATP12A	6.50e-07	162	197	8	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M ABCA8 PCDH18 SFRP2 FMOD CILP HMCN1 CLMP	2.24e-06	191	197	8	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 ITSN1 EBF1 CLMP	2.61e-06	195	197	8	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 ITSN1 EBF1 CLMP	2.61e-06	195	197	8	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 FZD1 PCDH18 FOXL1 SFRP2 FMOD HMCN1 CLMP	2.93e-06	198	197	8	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ABCA8 PCDH18 SFRP2 FMOD CILP EBF3 EBF1 CLMP	3.15e-06	200	197	8	2022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MARCHF10 TDRD9 NEK10 CFAP70 ERICH3 DNAI3 SLC9C2 ATP12A	3.15e-06	200	197	8	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Bronchus_Control_(B.)-Stromal-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ABCA8 PCDH18 SFRP2 FMOD CILP EBF3 EBF1 CLMP	3.15e-06	200	197	8	69b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M CPED1 ABCA8 SFRP2 EBF1 HMCN1 TENM1 CLMP	3.15e-06	200	197	8	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 GABRG2 LRP1B USH2A USP26 TENM1 ATP12A	3.84e-06	145	197	7	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M KLF12 ATG2A ATXN1 ERICH6B TENM1 PRKCQ	9.72e-06	167	197	7	abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPED1 ABCA8 XYLT1 CAMK1D EBF1 PLA2R1 CLMP	1.01e-05	168	197	7	d19a115365c5415e51c039718d7669de788fcf33
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M OBSCN ABCA8 TBC1D16 PCDH18 PRICKLE2 CLMP	1.27e-05	174	197	7	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GALK1 CPED1 XYLT1 PM20D1 SNX18 ASB2 ATP12A	1.32e-05	175	197	7	b80fe906043b3cb0b3ba761aadc9dc1c364aa1bf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GALK1 CPED1 XYLT1 PM20D1 SNX18 ASB2 ATP12A	1.32e-05	175	197	7	067c7d89cfdf6ebf70692df64b9b79d752f093dd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 ITSN1 EBF1 CLMP	1.47e-05	178	197	7	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	A2M ANKS1B CPED1 DTNA MTHFD1L EBF1 FRY	1.76e-05	183	197	7	818fd886e0188091310825f9145fa53328f2c979
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	A2M ANKS1B DTNA MTHFD1L HIPK2 OCA2 FRY	1.76e-05	183	197	7	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M OBSCN LRP1B USH2A ANK1 HMCN1 TENM1	1.82e-05	184	197	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M OBSCN LRP1B USH2A ANK1 HMCN1 TENM1	1.82e-05	184	197	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M OBSCN LRP1B USH2A ANK1 HMCN1 TENM1	1.82e-05	184	197	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	A2M KLF12 ANKS1B CPED1 DTNA MTHFD1L FRY	2.09e-05	188	197	7	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M OBSCN CPED1 PCDH18 FAM135B PRICKLE2 CLMP	2.09e-05	188	197	7	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	XYLT1 NFKB1 PRMT9 MTHFD1L PRICKLE2 CLMP MX2	2.16e-05	189	197	7	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN CPED1 ABCA8 EBF3 DTNA EBF1 FRY	2.24e-05	190	197	7	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.24e-05	190	197	7	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.24e-05	190	197	7	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.31e-05	191	197	7	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.39e-05	192	197	7	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.39e-05	192	197	7	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN MFN2 ERICH3 ANK1 YIPF7 LMOD3 ASB2	2.39e-05	192	197	7	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.39e-05	192	197	7	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN MFN2 ERICH3 ANK1 YIPF7 LMOD3 ASB2	2.39e-05	192	197	7	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 ATXN1 PCDH18 SFRP2 CLMP	2.39e-05	192	197	7	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.39e-05	192	197	7	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CPED1 ABCA8 SLC10A6 LRRC18 EBF3 DTX1 EBF1	2.47e-05	193	197	7	549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.47e-05	193	197	7	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ATR SRP72 GANAB CPD LATS1 PUM1 PUS7L	2.47e-05	193	197	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 ITSN1 EBF1 CLMP	2.47e-05	193	197	7	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	LA\|World / Chamber and Cluster_Paper	ANKS1B LRP1B ABCA8 XYLT1 CILP EBF1 PRICKLE2	2.47e-05	193	197	7	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 ITSN1 EBF1 CLMP	2.47e-05	193	197	7	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	SCFD2 KLF12 ATR MRPS27 IVD EBF1 GLMN	2.47e-05	193	197	7	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KLF12 CPED1 KLF5 ANK1 ASS1 TENM1 CLMP	2.47e-05	193	197	7	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	ANKS1B ABCA8 XYLT1 EBF1 ANKRD44 PRICKLE2 CLMP	2.56e-05	194	197	7	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 FOXL1 DTNA EBF1 FRY ASB2	2.56e-05	194	197	7	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 FOXL1 DTNA EBF1 FRY ASB2	2.56e-05	194	197	7	ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.64e-05	195	197	7	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	Bronchial_Biopsy-Mesenchymal-Fibroblasts\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	A2M CPED1 ABCA8 PCDH18 FOXL1 SFRP2 CLMP	2.64e-05	195	197	7	5870b2956d50d6550a3174a220a6cc70c5538d70
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CPED1 ABCA8 XYLT1 MTHFD1L EBF1 PLA2R1 CLMP	2.64e-05	195	197	7	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M ABCA8 PCDH18 SFRP2 FMOD HMCN1 CLMP	2.64e-05	195	197	7	51db90e7611f7d69980878c046505ff34212079b
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M ABCA8 FZD1 PCDH18 SFRP2 FMOD CLMP	2.73e-05	196	197	7	e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell	Bronchial_Biopsy-Mesenchymal\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	A2M CPED1 ABCA8 PCDH18 FOXL1 SFRP2 CLMP	2.73e-05	196	197	7	d37d821229dce716a05c2a5865415e10f79032de
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 ITSN1 EBF1 CLMP	2.73e-05	196	197	7	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 ITSN1 EBF1 CLMP	2.73e-05	196	197	7	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 ITSN1 EBF1 CLMP	2.82e-05	197	197	7	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.82e-05	197	197	7	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.82e-05	197	197	7	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	A2M ABCA8 DTNA EBF1 HMCN1 PRICKLE2 CLMP	2.82e-05	197	197	7	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CPED1 ABCA8 XYLT1 PCDH18 EBF1 CLMP	2.82e-05	197	197	7	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	A2M GABRG2 LRP1B XYLT1 NFATC1 FMOD FRY	2.91e-05	198	197	7	c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 FZD1 PCDH18 FMOD CILP HMCN1 CLMP	2.91e-05	198	197	7	7d2fe57e0f9311ac1e6854402ebc154306eb1ba5
ToppCell	COVID-19-kidney-Fibroblast-2\|kidney / Disease (COVID-19 only), tissue and cell type	A2M CPED1 ABCA8 PCDH18 EBF3 EBF1 CLMP	2.91e-05	198	197	7	ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	A2M GABRG2 LRP1B XYLT1 NFATC1 FMOD FRY	2.91e-05	198	197	7	55f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell	5'-Parenchyma_lung-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M ABCA8 PCDH18 SFRP2 FMOD CILP EBF1	2.91e-05	198	197	7	aae663c6da70b6e716edeed50cc7d3962d78e697
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M KLF12 UBR2 RNF213 ANKRD44 TENM1 SNRNP200	3.01e-05	199	197	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-3\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ABCA8 PCDH18 SFRP2 CILP EBF3 RADIL CLMP	3.01e-05	199	197	7	07b8c33342c62afd9c63ec2d757cfa3ba65d2a98
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 FZD1 FOXL1 SFRP2 HMCN1 TENM1 CLMP	3.01e-05	199	197	7	e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA8 PCDH18 SFRP2 CILP EBF3 EBF1 CLMP	3.01e-05	199	197	7	1fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M CPED1 XYLT1 DTNA MTHFD1L EBF1 ASB2	3.01e-05	199	197	7	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	Bronchial-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 PCDH18 SFRP2 FMOD CILP EBF1 CLMP	3.11e-05	200	197	7	5ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	A2M ABCA8 PCDH18 SFRP2 HMCN1 PRICKLE2 CLMP	3.11e-05	200	197	7	8ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	A2M ABCA8 PCDH18 SFRP2 FMOD HMCN1 CLMP	3.11e-05	200	197	7	4f7e26b27bd51c32420ed8c2f52d070aee542159
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-4\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ABCA8 PCDH18 SFRP2 FMOD CILP HMCN1 CLMP	3.11e-05	200	197	7	54b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCell	Biopsy_IPF-Mesenchymal-Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	A2M ABCA8 SFRP2 FMOD CILP EBF1 CLMP	3.11e-05	200	197	7	d8637f1e62d3fb9476dc51e1b1dc2f4b14b5fcd8
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_adventitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 PCDH18 SFRP2 FMOD CILP EBF1 CLMP	3.11e-05	200	197	7	b04831708fa20471a127b87e8db3728b6e729ce8
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M CPED1 ABCA8 SFRP2 EBF3 EBF1 CLMP	3.11e-05	200	197	7	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 PCDH18 SFRP2 FMOD CILP EBF1 CLMP	3.11e-05	200	197	7	6316c288022719b9e6c4332c5cb9041e1188d0e8
ToppCell	Biopsy_IPF-Mesenchymal\|Biopsy_IPF / Sample group, Lineage and Cell type	ABCA8 PCDH18 SFRP2 FMOD CILP EBF1 CLMP	3.11e-05	200	197	7	bb605b373caf3f873dc1b87d712704568e0d6040
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	A2M ABCA8 PCDH18 FOXL1 SFRP2 TENM1 CLMP	3.11e-05	200	197	7	16a3685c41194a0a4a772e4eee372160263480e0
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CPED1 ABCA8 SFRP2 EBF3 EBF1 TENM1 CLMP	3.11e-05	200	197	7	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	Biopsy_IPF-Mesenchymal-Myofibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	A2M ABCA8 PCDH18 SFRP2 FMOD HMCN1 CLMP	3.11e-05	200	197	7	c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR179 MEI4 MED12 PM20D1 KY	3.18e-05	82	197	5	89aff8676f98e062d0e69b38c7184e51aa1a915e
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR179 MEI4 MED12 PM20D1 KY	3.18e-05	82	197	5	6875a10abf1221b3dfd954c319b5e8e12fac1ff2
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR179 MEI4 MED12 PM20D1 KY	3.18e-05	82	197	5	259bb4ae0373d8352cb1c3bff08f66b89a298440
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RIPK2 PGD KCNU1 ATXN1 CAMK1D RASD2	4.24e-05	143	197	6	4a0f26eef935fe68a1da5d319503059a8a8682dd
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RIPK2 PGD KCNU1 ATXN1 CAMK1D RASD2	4.24e-05	143	197	6	65328a0a2f3972fac596e07933e74b2ef7cceb84
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B GDAP1L1 KL CILP EBF3 DOP1A	5.33e-05	149	197	6	7e295b2b82dea0754e98f8cef788e2781e5d641f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B GDAP1L1 KL CILP EBF3 DOP1A	5.33e-05	149	197	6	b4f77dc5f9d08b249fe5cd9a0acf86308c528ef4
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MARCHF10 NEK10 FAM120C DNAH8 OR5H14 DNAI3	5.53e-05	150	197	6	53de595376a9fc92491dfd58ff25938b0bf79903
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MARCHF10 NEK10 FAM120C DNAH8 OR5H14 DNAI3	5.53e-05	150	197	6	e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SLC12A9 PCDH18 FMOD DTX1 EBF1 HIF1AN	5.74e-05	151	197	6	8ba15ab24fe2e71df0a2a7511ca451ad2376bd91
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLF5 NMBR PCDH18 ANKRD44 ASS1 PRKCQ	6.40e-05	154	197	6	a2adaa4a6cd8708cd579b8efbeb4ff2131c5482e
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF12 CADM1 HPGDS ANK1 FAM135B ASB2	6.88e-05	156	197	6	5caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF12 CADM1 HPGDS ANK1 FAM135B ASB2	6.88e-05	156	197	6	758f57dc10fc5cad200bf5b310c10ec9b1405f23
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	4.12e-05	2	190	2	DOID:0110471 (implicated_via_orthology)
Disease	Alzheimer disease, APOE carrier status	SCFD2 ATG2A OR5K2 OR5K1 EBF1 FAM135B	4.24e-05	98	190	6	EFO_0007659, MONDO_0004975
Disease	hyperinsulinism (biomarker_via_orthology)	RPS6KB1 PRKCD PRKCQ	1.13e-04	15	190	3	DOID:2018 (biomarker_via_orthology)
Disease	Galactosemia	GALK1 GALT	1.23e-04	3	190	2	cv:C0016952
Disease	Galactosemias	GALK1 GALT	1.23e-04	3	190	2	C0016952
Disease	blood pressure, response to thiazide, response to beta blocker	OR5H1 OR5H14	1.23e-04	3	190	2	EFO_0004325, EFO_0007766, EFO_0007981
Disease	UDPglucose 4-epimerase deficiency disease	GALK1 GALT	1.23e-04	3	190	2	C0751161
Disease	TUMORAL CALCINOSIS, HYPERPHOSPHATEMIC, FAMILIAL, 1	KL FGF23	1.23e-04	3	190	2	C4692564
Disease	TUMORAL CALCINOSIS, HYPERPHOSPHATEMIC, FAMILIAL	KL FGF23	1.23e-04	3	190	2	C1876187
Disease	Classical galactosemia	GALK1 GALT	1.23e-04	3	190	2	C0268151
Disease	Deficiency of galactokinase	GALK1 GALT	1.23e-04	3	190	2	C0268155
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX11 DDX12P	1.23e-04	3	190	2	DOID:0060535 (implicated_via_orthology)
Disease	coronary artery calcification	MROH5 BCAT2 LRP1B ATXN1 UTP20 DMXL2 DTNA CPT1A FGF23 FRY PRICKLE2	1.74e-04	450	190	11	EFO_0004723
Disease	Colorectal Carcinoma	RPS6KB1 OBSCN F5 ABCA8 GDAP1L1 KL NFATC1 KLF5 DNAH8 SFRP2 MTHFD1L RNPEPL1 TENM1 SNRNP200	1.97e-04	702	190	14	C0009402
Disease	Hyperphosphatemia (disorder)	KL FGF23	2.45e-04	4	190	2	C0085681
Disease	cataract	SCFD2 NEK10 PKD1L1 LRP1B OCA2 CPT1A	3.14e-04	141	190	6	MONDO_0005129
Disease	asthma, Eczema	LRP1B OCA2	4.07e-04	5	190	2	HP_0000964, MONDO_0004979
Disease	portal hypertension (is_marker_for)	F5 PRKCD	6.08e-04	6	190	2	DOID:10762 (is_marker_for)
Disease	platelet-to-lymphocyte ratio	KLF12 PGD MED12L MFN2 KLC1 ANK1 RNPEPL1 EBF1 PLA2R1	6.11e-04	363	190	9	EFO_0008446
Disease	Alzheimer's disease 1 (implicated_via_orthology)	KLC1 KLC2	8.48e-04	7	190	2	DOID:0080348 (implicated_via_orthology)
Disease	Hereditary spherocytosis	DHODH ANK1	1.13e-03	8	190	2	C0037889
Disease	helping behavior measurement	KLF12 USH2A	1.13e-03	8	190	2	EFO_0008538
Disease	melanoma (is_implicated_in)	LRP1B NFKB1 ASS1	1.36e-03	34	190	3	DOID:1909 (is_implicated_in)
Disease	Abnormality of the face	UGP2 PUM1	1.44e-03	9	190	2	C4025871
Disease	Malignant neoplasm of breast	OBSCN HNRNPL CADM1 SLC10A6 UTP20 NMBR MED12 RAF1 SFRP2 ANK1 OCA2 CPT1A HELQ ANKEF1 TENM1 DOP1A	1.66e-03	1074	190	16	C0006142
Disease	comparative body size at age 10, self-reported	NEK10 RIPK2 ANKS1B LRP1B CADM1 NFATC1 GCN1 YIPF7 EBF1	1.69e-03	420	190	9	EFO_0009819
Disease	migraine disorder, Headache	NEMP1 CAMK1D RNF213 FGF23	2.34e-03	86	190	4	HP_0002315, MONDO_0005277
Disease	urate measurement, bone density	GABRG2 KLF12 ABCA8 HMG20A OR5K1 USH2A DNAH8 DDX12P MTHFD1L OR5K3 ASS1	2.36e-03	619	190	11	EFO_0003923, EFO_0004531
Disease	Tumoral calcinosis	KL RIPK3 FGF23	2.51e-03	42	190	3	C0263628
Disease	Calcinosis	KL RIPK3 FGF23	2.51e-03	42	190	3	C0006663
Disease	Microcalcification	KL RIPK3 FGF23	2.51e-03	42	190	3	C0521174
Disease	Amelogenesis Imperfecta	PEX1 FAM83H	2.61e-03	12	190	2	C0002452
Disease	velocity of sound measurement	CPED1 FOXL1	3.07e-03	13	190	2	EFO_0005654
Disease	cortisol measurement, response to corticosteroid, response to synacthen	ANKS1B LRP1B	3.07e-03	13	190	2	EFO_0005843, EFO_0009175, GO_0031960
Disease	skin melanoma (is_implicated_in)	DDR1 OCA2	3.57e-03	14	190	2	DOID:8923 (is_implicated_in)
Disease	rostral middle frontal gyrus volume measurement	PLA2R1 MAPK6	3.57e-03	14	190	2	EFO_0010328
Disease	Left ventricular noncompaction	PLEKHM2 DTNA	3.57e-03	14	190	2	C1960469
Disease	testosterone measurement	SCFD2 ANKS1B ABCA8 IVD NFATC1 NFKB1 USH2A MED12 RAF1 DDR1 AMPD3 SFRP2 EBF1 GLMN HMCN1 PRKCQ ATP12A	3.76e-03	1275	190	17	EFO_0004908
Disease	Common Variable Immunodeficiency	NFKB1 PRKCD	4.10e-03	15	190	2	C0009447
Disease	epilepsy (implicated_via_orthology)	GABRG2 LRP1B KCNU1 PRICKLE2 ATP12A	4.17e-03	163	190	5	DOID:1826 (implicated_via_orthology)
Disease	5-oxoproline measurement	GPAA1 DNAH8	4.66e-03	16	190	2	EFO_0010988
Disease	Drug-Induced Liver Disease	SRP72 GANAB RIPK3 NR5A2 SNX18 PRKCD EDEM1 PUM1	4.84e-03	404	190	8	C0860207
Disease	Drug-Induced Acute Liver Injury	SRP72 GANAB RIPK3 NR5A2 SNX18 PRKCD EDEM1 PUM1	4.84e-03	404	190	8	C3658290
Disease	Hepatitis, Toxic	SRP72 GANAB RIPK3 NR5A2 SNX18 PRKCD EDEM1 PUM1	4.84e-03	404	190	8	C0019193
Disease	Chemically-Induced Liver Toxicity	SRP72 GANAB RIPK3 NR5A2 SNX18 PRKCD EDEM1 PUM1	4.84e-03	404	190	8	C4279912
Disease	Chemical and Drug Induced Liver Injury	SRP72 GANAB RIPK3 NR5A2 SNX18 PRKCD EDEM1 PUM1	4.84e-03	404	190	8	C4277682
Disease	Hepatitis, Drug-Induced	SRP72 GANAB RIPK3 NR5A2 SNX18 PRKCD EDEM1 PUM1	4.84e-03	404	190	8	C1262760
Disease	response to cyclophosphamide	CAMK1D HIPK2	5.26e-03	17	190	2	GO_1902518
Disease	age at menarche	KLF12 LRP1B HMG20A TBC1D16 CADM1 HPGDS NEMP1 YIPF7 HELQ RTL1	5.35e-03	594	190	10	EFO_0004703
Disease	JT interval	KLF12 OBSCN FAM13B NFKB1 CFAP70 TASOR	5.55e-03	248	190	6	EFO_0007885
Disease	alcoholic hepatitis (biomarker_via_orthology)	NFKB1 CPT1A	5.90e-03	18	190	2	DOID:12351 (biomarker_via_orthology)
Disease	food allergy measurement, parental genotype effect measurement	SFRP2 CLMP	5.90e-03	18	190	2	EFO_0005939, EFO_0007016

Protein segments in the cluster

Peptide	Gene	Start	Entry
MNATGNPYLDDIGLL	USP26	241	Q9BXU7
HGMVYNDLLQNPLLV	BOP1	691	Q14137
QIHYPSGNLAMLILY	ERICH6B	496	Q5W0A0
MIYLGKNVHLSSDNP	ERICH3	291	Q5RHP9
ALLNNIPYHEGFKMA	PRMT9	526	Q6P2P2
PGIQSLMHEFYDVAN	CPED1	476	A4D0V7
AMPQNYQDSLGHEVI	AKAP4	746	Q5JQC9
TMQLLLDHGANIDAY	ASB2	456	Q96Q27
GFTPLYMAAQENHLE	ANK1	111	P16157
QAAQGPTISYPMLLH	DDR1	731	Q08345
QEHYLPSAILQLGME	GPR15	271	P49685
LIGSLPEQYMLEQGH	BNC1	256	Q01954
AMDLLYILPTHIQAA	CPT1A	256	P50416
DGYRHEMLPASLIQA	PGD	431	P52209
LISINGNTPLHYAAM	ANKEF1	246	Q9NU02
LQYLHAQPITCQGMF	DOP1A	1626	Q5JWR5
LSVHQLAAQGEMLYL	ANKRA2	151	Q9H9E1
QYHPTQLLELMDLGK	DMXL2	1346	Q8TDJ6
GPAIQDAYMHITSVL	ADCY10	311	Q96PN6
LAVYSLAPHNLGEML	AMBRA1	921	Q9C0C7
QAAYPAMVQAQIHLP	ATXN1	541	P54253
NNEPLTHAMYNLASL	DHX30	321	Q7L2E3
NPYHNLESGMANLLK	DNAI3	611	Q8IWG1
GYAQVIPMEEFNLHL	MTHFD1L	471	Q6UB35
VNLLQYVMSTGDLHP	ATG2A	1231	Q2TAZ0
MHISYEAGILENPKN	ASS1	186	P00966
QLQQYEMHGPEGLRV	A2M	691	P01023
PNLDYLVHMQGGILF	AMPD3	216	Q01432
LMTGELPYSHINNRD	RAF1	541	P04049
TQAVPLLMAHQYLRG	OCA2	311	Q04671
HTPMYIFLGNLALVD	OR5K2	56	Q8NHB8
MPEVGSLQHARVLQY	GDAP1L1	131	Q96MZ0
YTALLQPHDRIMGLD	SHMT2	151	P34897
HIPMYLLLGNLAFVD	OR5H15	56	A6NDH6
VSQLLSMLHQGQYQP	PCDH18	831	Q9HCL0
YLTHQNGSIMEGLAL	LTN1	1686	O94822
QGSDPSLQPYLLMAH	PM20D1	111	Q6GTS8
LQVHPEVASQMLAYL	RADIL	626	Q96JH8
SIGLPQYENHLMANG	ANKS1B	821	Q7Z6G8
LGIPYRVIHNASIMN	DPH5	101	Q9H2P9
QLVDYIHNGFLVPVM	FHIP1B	321	Q8N612
HIPMYLLLGNLAFVD	OR5H14	56	A6NHG9
HNPMYFLLANLSLVD	OR1A2	56	Q9Y585
NTMNNYGVLLHELGL	OGFOD2	171	Q6N063
LNQSLHVPMYLFLLN	OR10A3	51	P58181
GLPSALEQLYMEHNN	FMOD	241	Q06828
GVLLYEMLIGQSPFH	PRKCQ	566	Q04759
FNYNEIDPSLGHMIV	NMBR	291	P28336
YNPIMQQPALLTGHV	HIPK2	761	Q9H2X6
LLTNMAGEPYAIAVN	LRP1B	4021	Q9NZR2
QHGPLVYGLSCMLQT	MED12L	356	Q86YW9
AMGLALYVLPVLGQH	GPAA1	436	O43292
YMGIALHNELLLSAA	GPR179	576	Q6PRD1
LLLIGMEGNVTPAHY	HIF1AN	186	Q9NWT6
SHNMELYNISVPGLQ	LATS1	416	O95835
VLLYEMLIGQSPFHG	PRKCD	536	Q05655
ANNTLLKMGYHFELP	LMOD3	366	Q0VAK6
ENNHLEYLPVSLGSM	LRRIQ4	406	A6NIV6
YMNRLHSIILANPQD	HMG20A	316	Q9NP66
NYVDMGVQLPAELHQ	KY	436	Q8NBH2
NQPLAVYSYLHIGLM	ATP12A	861	P54707
PGSLHIHLMQLSQDY	FAM13B	111	Q9NYF5
FNELLTYNAPHLMQD	HPGDS	116	O60760
HYDRIQSLLMANLPQ	HPS4	606	Q9NQG7
ILHSLGGIENLAQYM	NEK10	151	Q6ZWH5
QGPLLEEHARLFMYQ	MAPK6	121	Q16659
SPLVHVIMANIYLLA	OR51Q1	271	Q8NH59
FMYSGIQIPHIALAI	NEMP1	291	O14524
PLYNHDLVSMAHGIQ	DNAH8	246	Q96JB1
IGEHTDYNQGLVLPM	GALK1	41	P51570
VQLHGYLENEPLMLQ	NFATC1	461	O95644
YRDLKPENIMLNHQG	RPS6KB1	216	P23443
HSNYIDKLPESIGQM	LRRC18	81	Q8N456
LGMSYHLPLVQHVQF	MED12	861	Q93074
VAGLSMQIFAPYVHL	GDPD4	96	Q6W3E5
AILSLEPNQNYAGML	GCN1	186	Q92616
NYHVLELLQMLVTGG	KCNU1	916	A8MYU2
QTPLMLAVAYGHIDA	ANKRD44	671	Q8N8A2
LIHGLAQLYQARPML	AP5B1	486	Q2VPB7
IEQRLHTPMYIFLGN	OR5K3	51	A6NET4
AGAYLAGNLHPMIEV	OR5K3	146	A6NET4
ATTALLHYQLPQMPD	MED27	246	Q6P2C8
AAQLVVLPYQMLLHA	DDX11	361	Q96FC9
VLPYQMLLHAATRQA	DDX11	366	Q96FC9
GLMQAVLDHTIPYLH	IVD	296	P26440
DAQLVPYIIDLQSMH	DTX1	66	Q86Y01
LDSELNMFTHQYLQP	MFN2	741	O95140
HTPMYIFLGNLALVD	OR5K1	56	Q8NHB7
NTPFLYDLVMTHALQ	RBBP7	26	Q16576
LIRLVAYTQDGVMHP	HMCN1	5551	Q96RW7
HPDVATMLNILALVY	KLC2	236	Q9H0B6
HIPMYLLLGNLAFVD	OR5H1	56	A6NKK0
YPNLQLREIAGHIME	PUM1	841	Q14671
SLNGMPLYNDSFHEI	OBSCN	2591	Q5VST9
NKLHVSLMENYPGTL	OBSCN	5876	Q5VST9
EMEGNLHQLSNPIGY	PRICKLE2	616	Q7Z3G6
IFIHMPNLIEYLQSL	B3GNT5	196	Q9BYG0
HIQMTYPLQGLTREG	CADM1	246	Q9BY67
DIAYNQTIMPNLLGH	FZD1	126	Q9UP38
QLDEHMGYLQSAPLQ	ATR	181	Q13535
LSFHGVAYVNMVPLL	CFAP70	336	Q5T0N1
QQAYKSQHGEPLLME	GALT	206	P07902
VDGAPHQTIYSALMI	FGF23	61	Q9GZV9
GDILSAQLPHMQPYI	ITSN1	1316	Q15811
GLGPSHLDMNYVLQQ	HAP1	616	P54257
MNFPIFAALLGNHIL	FAM120C	306	Q9NX05
LIHTDMYVNSIGPVN	GABRG2	91	P18507
EFLRGLVMNYPHITN	CPD	941	O75976
LVMNYPHITNLTNLG	CPD	946	O75976
AQLVVLPYQMLLHAA	DDX12P	381	Q92771
HLYVLQALMLGLLEP	ELMO3	281	Q96BJ8
VEALYGMPHNNQEII	EBF1	386	Q9UH73
KNPFYLHVGMDILQS	EDEM1	506	Q92611
NELMNSGLYLVLLLH	MARCHF10	741	Q8NA82
HVLIGLYVNMLRNNP	DTNA	406	Q9Y4J8
LETLGFLNHYQMKNP	HNRNPL	556	P14866
SLMLDPHVQGGFYQL	FOXL1	311	Q12952
LPMYIISNGIDDGLH	KL	866	Q9UEF7
HNYPDMEAVPLLLNN	KLF12	46	Q9Y4X4
GSQIPCIQMALQAHY	FAM172BP	136	A6NC97
GLMYSQLPHHILADV	EEF2K	571	O00418
PNTGNMHIVADLYAE	FRY	216	Q5TBA9
RHTGPVYAEMINNLL	FAM135B	1336	Q49AJ0
GYKSLMHLANANPEV	HELQ	1031	Q8TDG4
LVEALYGMPHNNQEI	EBF3	386	Q9H4W6
PVYILLDEMNAQHFL	FAM83H	176	Q6ZRV2
LYKDRNLHIPTMENG	BCAT2	351	O15382
VLQAPGNTSCLLHYM	CREB3	301	O43889
LYNAQLEALHGMLLS	PEX1	1051	O43933
DSALQYHLMLPQLVF	PKD1L1	2516	Q8TDX9
HLGMYLPNEAGLQDE	CYP4F22	71	Q6NT55
HPDVATMLNILALVY	KLC1	251	Q07866
VFGQPLDLHYMNNEL	MAP3K3	76	Q99759
LDQSLHVPMYLFLLN	OR10A6	51	Q8NH74
LPLDFHIMGNVVYAI	OR2AT4	271	A6NND4
TGHMEGNLQLLYVLL	PLEKHM2	616	Q8IWE5
HNPMYFLLANLSLVD	OR1A1	56	Q9P1Q5
QMHYVLELNLPSEPQ	MROH5	911	Q6ZUA9
HLNGDVPYNNLLIEM	NR5A2	521	O00482
YLVFVQGIHIDQLPM	GLMN	291	Q92990
VLSPLYLLQFNMGHI	GLMN	306	Q92990
PLSSHMQFLQYLLEL	MEI4	146	A8MW99
LQQGLRAVYHNMPLI	MRPS27	236	Q92552
YIQMIPELFDQLHGA	RTL1	646	A6NKG5
STELFQDHMLQYVLP	USH2A	2196	O75445
LIPVMHNCFYNLELG	UTP20	1471	O75691
VNPSHLMNLFTYEKG	RNPEPL1	431	Q9HAU8
HGIEYQNMRLPNLLG	SFRP2	51	Q96HF1
NKMQLPENYLHGRLT	TRIM42	201	Q8IWZ5
LDNITLVMVFHPQYL	SESN1	81	Q9Y6P5
ENRLVMGGPQQLYHL	PIH1D1	241	Q9NWS0
ALDVPHLSNYILNLM	TCP11X1	151	B4DZS4
ALDVPHLSNYILNLM	TCP11X2	56	Q5H9J9
FLPGLGEINYMHELL	TDRD9	391	Q8NDG6
LTPKHLQAGMQAYID	F5	311	P12259
ANMYAIHQVVLPVLG	PUS7L	586	Q9H0K6
NPMALYGSVPVLLAH	GANAB	291	Q14697
FYAEHLMPTLQGLLD	DHODH	36	Q02127
MSALYHIAQNESPVL	TAOK2	231	Q9UL54
AHLNDMNIYEIASPA	TENM1	1526	Q9UKZ4
NMNYTAEVFHVPLLL	SCFD2	146	Q8WU76
MQNILEPSYRGLLHA	SLC25A43	136	Q8WUT9
PQAELAIIHGQMAYI	SRP72	221	O76094
MPLINASYVAGILHA	OR5T2	181	Q8NGG2
PNHLYLVMQLVSGGE	CAMK1D	91	Q8IU85
MITGPLQYSVQVAHD	PLA2R1	121	Q13018
ALQILVQAYLHMPPE	STRC	726	Q7RTU9
YQSMEILHCLGPDNQ	ERVK-9	841	P63128
GLIYLFTPNMHILQN	SLC6A18	236	Q96N87
TYLIQSVPAELNMDH	SNF8	166	Q96H20
YADLLQANPLDTGAM	TASOR	221	Q9UK61
LGMAQLLHLDYDLNS	ABCA8	371	O94911
DYNHPGRVLLQNLTM	CLMP	186	Q9H6B4
ASVNPMLHEYLVNHL	CILP	1036	O75339
QGPLAMLQHFDTIYS	NCAPD2	51	Q15021
YVALALGDNLMALNH	CNOT10	541	Q9H9A5
GHSEVLPAALAVYMQ	RNF213	1836	Q63HN8
GATVDLYILNHLMNP	UGP2	256	Q16851
LKLHNGPLRNAYMEQ	XYLT1	856	Q86Y38
MEGLLHYINPAHAIS	ZBTB21	1	Q9ULJ3
LGMFYLHDQNPVLLH	RIPK3	126	Q9Y572
DLMQLYTHVSENLPP	SLC27A3	601	Q5K4L6
HEIALGVNYLHNMTP	RIPK2	126	O43353
DPVMDLLALYQGHLA	SNX18	516	Q96RF0
MQHSLAGQTYAVPLI	WASH2P	6	Q6VEQ5
HAGLLQALAMLLVAY	SLC12A9	66	Q9BXP2
YQHLVSLGEDGLQML	TBC1D16	591	Q8TBP0
HYLVLNTPLEDNIMT	SLC25A27	216	O95847
MQHSLAGQTYAVPLI	WASH3P	6	C4AMC7
MYQLDILDTSGNHPF	RASD2	66	Q96D21
EHLVQMLSFPLAYGL	SLC10A6	281	Q3KNW5
LSLMSQGLLYPHQVP	PSME4	1626	Q14997
DVMSQNPYNAVIHLG	WDR46	321	O15213
EPGKINHMRYDTLAQ	TRMT6	176	Q9UJA5
IYDVLQMVGHANRPL	SNRNP200	1681	O75643
QYGEAIHQMPDLTLH	ZNF57	116	Q68EA5
PQGIYLIISGMAILH	SLC9C2	901	Q5TAH2
ALQILVQAYLHMPPE	STRCP1	726	A6NGW2
PAFTMLGYLNEHLQL	TTC37	981	Q6PGP7
QLPESAYMHQLLGLN	PSMD8	181	P48556
IAALHMEGQQLLVAY	YIPF7	251	Q8N8F6
AMLETLQNAPYLEVH	UBR2	971	Q8IWV8
GHLYQLLNTPDLDMP	KLF5	226	Q13887
HQYIQQLVEPALSML	MX2	506	P20592
NMRNDLYQTPLHLAV	NFKB1	576	P19838
ASLLTLNKMPHDYGQ	NFKB1	946	P19838