Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	1.38e-04	5	75	2	GO:0140444
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly	IQGAP3 IQGAP1	3.80e-05	3	74	2	GO:1903475
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	3.80e-05	3	74	2	GO:1903479
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in mitotic cytokinesis	IQGAP3 IQGAP1	3.80e-05	3	74	2	GO:1902407
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	7.58e-05	4	74	2	GO:2000689
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A1 CSNK2A3	7.38e-05	4	74	2	GO:0005956
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE1 SYNE2	6.66e-04	11	74	2	GO:0034992
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE1 SYNE2	6.66e-04	11	74	2	GO:0034993
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE1 SYNE2	6.66e-04	11	74	2	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE1 SYNE2	6.66e-04	11	74	2	GO:0106094
MousePheno	postnatal growth retardation	RELN ERCC2 RGS5 SH3RF2 SYNE1 LTN1 PKHD1 GOLGA8B CHD2 CHD7 GOLGA8A DYNC1H1 TG	1.80e-05	881	53	13	MP:0001732
MousePheno	abnormal postnatal growth	RELN ERCC2 RGS5 SH3RF2 SYNE1 LTN1 PKHD1 GOLGA8B CHD2 CHD7 GOLGA8A DYNC1H1 TG	2.45e-05	907	53	13	MP:0001731
MousePheno	hydrops fetalis	NF1 CSNK2A1 SYK RICTOR	4.70e-05	53	53	4	MP:0002192
Domain	RasGAP	NF1 IQGAP3 IQGAP1	1.94e-05	14	72	3	SM00323
Domain	RasGAP_CS	NF1 IQGAP3 IQGAP1	1.94e-05	14	72	3	IPR023152
Domain	RasGAP	NF1 IQGAP3 IQGAP1	2.42e-05	15	72	3	PF00616
Domain	RAS_GTPASE_ACTIV_1	NF1 IQGAP3 IQGAP1	2.42e-05	15	72	3	PS00509
Domain	RAS_GTPASE_ACTIV_2	NF1 IQGAP3 IQGAP1	2.42e-05	15	72	3	PS50018
Domain	RasGAP_dom	NF1 IQGAP3 IQGAP1	4.30e-05	18	72	3	IPR001936
Domain	RasGAP_C	IQGAP3 IQGAP1	4.39e-05	3	72	2	IPR000593
Domain	RasGAP_C	IQGAP3 IQGAP1	4.39e-05	3	72	2	PF03836
Domain	KASH	SYNE1 SYNE2	8.75e-05	4	72	2	PF10541
Domain	KASH	SYNE1 SYNE2	8.75e-05	4	72	2	IPR012315
Domain	KASH	SYNE1 SYNE2	8.75e-05	4	72	2	PS51049
Domain	KASH	SYNE1 SYNE2	8.75e-05	4	72	2	SM01249
Domain	CH	SYNE1 SYNE2 IQGAP3 IQGAP1	1.15e-04	65	72	4	SM00033
Domain	CH	SYNE1 SYNE2 IQGAP3 IQGAP1	1.54e-04	70	72	4	PF00307
Domain	-	SYNE1 SYNE2 IQGAP3 IQGAP1	1.62e-04	71	72	4	1.10.418.10
Domain	CH	SYNE1 SYNE2 IQGAP3 IQGAP1	1.81e-04	73	72	4	PS50021
Domain	CH-domain	SYNE1 SYNE2 IQGAP3 IQGAP1	2.01e-04	75	72	4	IPR001715
Domain	DNA/RNA_helicase_DEAH_CS	ERCC2 CHD2 CHD7	3.29e-04	35	72	3	IPR002464
Domain	DEAH_ATP_HELICASE	ERCC2 CHD2 CHD7	4.21e-04	38	72	3	PS00690
Domain	-	IQGAP3 IQGAP1	1.70e-03	16	72	2	1.10.506.10
Domain	GOLGA2L5	GOLGA8B GOLGA8A	2.15e-03	18	72	2	PF15070
Domain	Golgin_A	GOLGA8B GOLGA8A	2.15e-03	18	72	2	IPR024858
Domain	Actinin_actin-bd_CS	SYNE1 SYNE2	3.52e-03	23	72	2	IPR001589
Domain	Spectrin	SYNE1 SYNE2	3.52e-03	23	72	2	PF00435
Domain	ACTININ_2	SYNE1 SYNE2	3.52e-03	23	72	2	PS00020
Domain	ACTININ_1	SYNE1 SYNE2	3.52e-03	23	72	2	PS00019
Domain	Chromo_domain	CHD2 CHD7	3.83e-03	24	72	2	IPR023780
Domain	SEC14	NF1 SEC14L1	4.15e-03	25	72	2	SM00516
Domain	Chromo	CHD2 CHD7	4.49e-03	26	72	2	PF00385
Domain	Rho_GTPase_activation_prot	NF1 IQGAP3 IQGAP1	4.77e-03	88	72	3	IPR008936
Domain	CRAL_TRIO	NF1 SEC14L1	4.83e-03	27	72	2	PS50191
Domain	P-loop_NTPase	ERCC2 SAMD9L RNF213 CHD2 TOR1B CHD7 DYNC1H1 ARF3 IQGAP1	5.15e-03	848	72	9	IPR027417
Domain	CHROMO_1	CHD2 CHD7	5.19e-03	28	72	2	PS00598
Domain	CHROMO_2	CHD2 CHD7	5.19e-03	28	72	2	PS50013
Domain	CRAL-TRIO_dom	NF1 SEC14L1	5.19e-03	28	72	2	IPR001251
Domain	Spectrin_repeat	SYNE1 SYNE2	5.56e-03	29	72	2	IPR002017
Domain	SNF2_N	CHD2 CHD7	6.75e-03	32	72	2	IPR000330
Domain	Spectrin/alpha-actinin	SYNE1 SYNE2	6.75e-03	32	72	2	IPR018159
Domain	Chromodomain-like	CHD2 CHD7	6.75e-03	32	72	2	IPR016197
Domain	SNF2_N	CHD2 CHD7	6.75e-03	32	72	2	PF00176
Domain	SPEC	SYNE1 SYNE2	6.75e-03	32	72	2	SM00150
Domain	Chromo/shadow_dom	CHD2 CHD7	7.16e-03	33	72	2	IPR000953
Domain	CHROMO	CHD2 CHD7	7.16e-03	33	72	2	SM00298
Pathway	PID_LIS1_PATHWAY	RELN CSNK2A1 DYNC1H1 IQGAP1	5.62e-06	28	60	4	M163
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PDE4A NF1 CENPF GPR158 CSNK2A1 SYNE1 SYNE2 GOLGA8B WDR18 CHD7 GOLGA8A HOMER1 DYNC1H1 ARF3 IQGAP1 EPM2AIP1	2.42e-10	963	76	16	28671696
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NF1 CENPF CSNK2A1 SYNE2 XRN1 WDR18 CHD2 CHD7 PHIP DYNC1H1 ARF3 IQGAP1	1.80e-08	653	76	12	22586326
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NF1 SYNE1 MAPK10 HOMER1 DYNC1H1 ARF3 IQGAP1	2.83e-06	281	76	7	28706196
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	RELN SYNE1 SYNE2	3.59e-06	14	76	3	19874786
Pubmed	ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation.	ZNF674 KRBOX4	4.71e-06	2	76	2	16385466
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	4.71e-06	2	76	2	11792814
Pubmed	Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.	NF1 DYNC1H1	4.71e-06	2	76	2	23583712
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A1 CSNK2A3	4.71e-06	2	76	2	14646071
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	4.71e-06	2	76	2	24931616
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A1 CSNK2A3	4.71e-06	2	76	2	12860116
Pubmed	The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1.	PTPRM IQGAP1	4.71e-06	2	76	2	16380380
Pubmed	Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen.	GOLGA8B GOLGA8A	4.71e-06	2	76	2	10677249
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	4.71e-06	2	76	2	22768332
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A1 CSNK2A3	4.71e-06	2	76	2	1577469
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	4.71e-06	2	76	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	4.71e-06	2	76	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	4.71e-06	2	76	2	24586179
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	4.71e-06	2	76	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	4.71e-06	2	76	2	31578382
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A1 CSNK2A3	4.71e-06	2	76	2	2752008
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A1 CSNK2A3	4.71e-06	2	76	2	8420794
Pubmed	Identification and characterization of a novel Golgi protein, golgin-67.	GOLGA8B GOLGA8A	4.71e-06	2	76	2	10660574
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A1 CSNK2A3	1.41e-05	3	76	2	15684395
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A1 CSNK2A3	1.41e-05	3	76	2	2174700
Pubmed	Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.	CSNK2A1 CSNK2A3	1.41e-05	3	76	2	1766873
Pubmed	The biology of IQGAP proteins: beyond the cytoskeleton.	IQGAP3 IQGAP1	1.41e-05	3	76	2	25722290
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	1.41e-05	3	76	2	16079285
Pubmed	G-quadruplexes in the BAP1 promoter positively regulate its expression.	CHD2 CHD7	1.41e-05	3	76	2	29787736
Pubmed	Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.	IQGAP3 IQGAP1	1.41e-05	3	76	2	25229330
Pubmed	Crystallization and preliminary characterization of crystals of human protein kinase CK2.	CSNK2A1 CSNK2A3	1.41e-05	3	76	2	11092945
Pubmed	Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.	CSNK2A1 CSNK2A3	1.41e-05	3	76	2	12102635
Pubmed	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	CSNK2A1 CSNK2A3	1.41e-05	3	76	2	20625391
Pubmed	Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.	SAMD9L IQGAP1	1.41e-05	3	76	2	26078295
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	1.41e-05	3	76	2	10878022
Pubmed	IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.	IQGAP3 IQGAP1	1.41e-05	3	76	2	22493426
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	1.41e-05	3	76	2	12408964
Pubmed	The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons.	HOMER1 TBC1D24	1.41e-05	3	76	2	30335140
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	1.41e-05	3	76	2	17462627
Pubmed	Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.	CHD2 CHD7	1.41e-05	3	76	2	30277262
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	1.41e-05	3	76	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	1.41e-05	3	76	2	25516977
Pubmed	Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.	RELN GOLGA8B GOLGA8A	1.72e-05	23	76	3	21111240
Pubmed	Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.	RELN GOLGA8B GOLGA8A	1.96e-05	24	76	3	26060116
Pubmed	CDK5RAP2 expression during murine and human brain development correlates with pathology in primary autosomal recessive microcephaly.	RELN GOLGA8B GOLGA8A	2.51e-05	26	76	3	22806269
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	2.82e-05	4	76	2	16648470
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2	2.82e-05	4	76	2	28716842
Pubmed	Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase.	CSNK2A1 SYK	2.82e-05	4	76	2	3472906
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2	2.82e-05	4	76	2	23071752
Pubmed	Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.	CHD7 FAM124B	2.82e-05	4	76	2	23285124
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2	2.82e-05	4	76	2	20108321
Pubmed	Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.	IQGAP3 IQGAP1	2.82e-05	4	76	2	28970065
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	2.82e-05	4	76	2	19596800
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NF1 SETD1B LTN1 XRN1 RICTOR RAI14 CHD2 CHD7 PHIP DYNC1H1 POLR3A IQGAP1	3.55e-05	1353	76	12	29467282
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ZNF106 ANPEP CENPF SYNE1 WDR18 RAI14 IQGAP3 HOMER1 DYNC1H1 ARF3 IQGAP1	4.10e-05	1155	76	11	20360068
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2	4.69e-05	5	76	2	22632968
Pubmed	Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress.	CSNK2A1 DYNC1H1	4.69e-05	5	76	2	21486957
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2	4.69e-05	5	76	2	18396275
Pubmed	Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.	CSNK2A1 GRB14	4.69e-05	5	76	2	24535599
Pubmed	Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.	TCHH GOLGA8B GOLGA8A	5.71e-05	34	76	3	19956733
Pubmed	Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.	CSNK2A1 RICTOR RAI14	6.24e-05	35	76	3	30942445
Pubmed	Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.	MAPK10 DYNC1H1	7.03e-05	6	76	2	19525941
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	7.03e-05	6	76	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	7.03e-05	6	76	2	18827015
Pubmed	Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.	MYOM1 SYNE2	7.03e-05	6	76	2	38569934
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	NF1 LTN1 RNF213 RICTOR	8.20e-05	104	76	4	31240132
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	LTN1 XRN1 RICTOR IQGAP3 IQGAP1	8.32e-05	202	76	5	33005030
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRMT10C ERCC2 CSNK2A1 SYNE1 LTN1 XRN1 RICTOR RAI14 CHD2 CHD7 IQGAP3 IQGAP1	9.35e-05	1497	76	12	31527615
Pubmed	Genome-wide analysis of H4K5 acetylation associated with fear memory in mice.	SFI1 ZNF101	9.83e-05	7	76	2	23927422
Pubmed	Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain.	RELN HOMER1	9.83e-05	7	76	2	21664258
Pubmed	Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress.	XRN1 RICTOR	9.83e-05	7	76	2	21964062
Pubmed	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.	CSNK2A1 CSNK2A3	9.83e-05	7	76	2	11239457
Pubmed	Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.	RELN GOLGA8B GOLGA8A	1.08e-04	42	76	3	24210661
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ZNF106 CENPF CSNK2A1 RAI14 CHD2 CSNK2A3 HOMER1	1.09e-04	497	76	7	36774506
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	CSNK2A1 CSNK2A3	1.31e-04	8	76	2	12393879
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	RICTOR IQGAP3 ARF3 IQGAP1	1.43e-04	120	76	4	27320910
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	ERCC2 CENPF LTN1 WDR18 IQGAP3 DYNC1H1 POLR3A IQGAP1	1.52e-04	704	76	8	29955894
Pubmed	Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.	NF1 RICTOR	1.68e-04	9	76	2	27340174
Pubmed	Typing recombinant inbred mouse strains for microsatellite markers.	ANPEP TG	1.68e-04	9	76	2	8507976
Pubmed	Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome.	CHD7 KISS1	1.68e-04	9	76	2	21596839
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SAMD9L CENPF PKHD1 RNF213 CHD2 EEF1AKMT1 CHML DYNC1H1	2.06e-04	736	76	8	29676528
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE1 SYNE2	2.10e-04	10	76	2	28533284
Pubmed	Nuclear membrane proteins with potential disease links found by subtractive proteomics.	SYNE1 SYNE2	2.10e-04	10	76	2	12958361
Pubmed	Analysis of the DNA sequence and duplication history of human chromosome 15.	ANPEP GOLGA8B CHD2	2.56e-04	56	76	3	16572171
Pubmed	Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.	ANPEP CENPF HOMER1	2.56e-04	56	76	3	30104731
Pubmed	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.	RELN CHD7	2.56e-04	11	76	2	28165338
Pubmed	A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.	SYNE1 SYNE2	2.56e-04	11	76	2	22826121
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRMT10C ATP6V1H NF1 CENPF CSNK2A1 SYNE1 IQGAP3 PHIP DYNC1H1 POLR3A IQGAP1	2.61e-04	1425	76	11	30948266
Pubmed	IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.	IQGAP3 IQGAP1	3.07e-04	12	76	2	18604197
Pubmed	Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.	CSNK2A1 SFI1 DYNC1H1	3.29e-04	61	76	3	7790358
Pubmed	Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.	RELN TG	3.62e-04	13	76	2	22724066
Pubmed	KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.	SYNE1 SYNE2	3.62e-04	13	76	2	21177258
Pubmed	Globozoospermia and lack of acrosome formation in GM130-deficient mice.	GOLGA8B GOLGA8A	3.62e-04	13	76	2	28055014
Pubmed	GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells.	GOLGA8B GOLGA8A	3.62e-04	13	76	2	33740186
Pubmed	Loss of GM130 does not impair oocyte meiosis and embryo development in mice.	GOLGA8B GOLGA8A	3.62e-04	13	76	2	32873390
Pubmed	GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte.	GOLGA8B GOLGA8A	3.62e-04	13	76	2	21552007
Pubmed	Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice.	GOLGA8B GOLGA8A	3.62e-04	13	76	2	28028212
Pubmed	GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver.	GOLGA8B GOLGA8A	3.62e-04	13	76	2	29128360
Pubmed	Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation.	SYNE2 GOLGA8B GOLGA8A	3.80e-04	64	76	3	34174788
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NF1 CENPF CSNK2A1 SYNE1 SYNE2 WDR18 PHIP DYNC1H1 IQGAP1	3.91e-04	1024	76	9	24711643
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	SETD1B CSNK2A1 CHD2 CHD7	3.98e-04	157	76	4	30186101
GeneFamily	DNA helicases	ERCC2 CHD2 CHD7	1.02e-05	17	46	3	1167
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	3.79e-05	4	46	2	1252
Coexpression	GSE22601_DOUBLE_NEGATIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_DN	ZNF106 TAMM41 TLR5 XRN1 ZNF749 TBC1D24 SEC14L1	1.78e-06	198	76	7	M6230
Coexpression	GSE1566_WT_VS_EZH2_KO_LN_TCELL_DN	TAMM41 PTPRM TLR5 XRN1 TBC1D24 SEC14L1	2.43e-05	198	76	6	M6224
Coexpression	GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN	ZNF106 SETD1B SYK RICTOR PHIP ARF3	2.57e-05	200	76	6	M5851
Coexpression	GAUTAM_EYE_IRIS_CILIARY_BODY_ACTIVATED_T_CELLS	GOLGA8B RNF213 SFI1 GOLGA8A IQGAP1	3.59e-05	128	76	5	M43603
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN	SETD1B GOLGA8B RICTOR CHD2 CHD7 SFI1 ATG2A GOLGA8A	3.61e-05	432	76	8	M41149
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SYNE1 SYNE2 PKHD1 RNF213 CHD2 SFI1 ATG2A GOLGA8A	8.46e-11	135	76	8	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SYNE2 PAFAH2 GOLGA8B RNF213 SFI1 ATG2A GOLGA8A	1.71e-09	197	76	8	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SYNE2 GOLGA8B RNF213 RICTOR CHD2 SFI1 GOLGA8A	1.85e-09	199	76	8	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L SYNE2 XRN1 RNF213 CHD2 GOLGA8A PHIP DYNC1H1	1.93e-09	200	76	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPRM ANXA3 PKHD1 GRB14 GOLGA8B RAI14 GOLGA8A	3.66e-08	190	76	7	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9L SYNE1 SYNE2 XRN1 RNF213 RICTOR CHD2	4.86e-08	198	76	7	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SAMD9L NF1 PTPRM RGS5 RNF213 RAI14 SEC14L1	5.21e-08	200	76	7	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L SYNE1 SYNE2 XRN1 RNF213 ATG2A GOLGA8A	5.21e-08	200	76	7	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	SYNE1 SYNE2 GOLGA8B RNF213 SFI1 GOLGA8A	2.82e-07	156	76	6	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE1 SYNE2 RNF213 CHD2 SFI1 GOLGA8A	4.84e-07	171	76	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SYNE2 RNF213 CHD2 SFI1 GOLGA8A EPM2AIP1	6.75e-07	181	76	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RICTOR ATG2A CHML GOLGA8A HOMER1 SEC14L1	8.17e-07	187	76	6	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	NF1 SYNE2 RNF213 RICTOR CHD2 DYNC1H1	8.43e-07	188	76	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SYNE2 GOLGA8B RNF213 SFI1 GOLGA8A	9.82e-07	193	76	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	PTPRM RGS5 SYNE1 ANXA3 SYNE2 SEC14L1	9.82e-07	193	76	6	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	PTPRM RGS5 SYNE1 ANXA3 SYNE2 SEC14L1	1.01e-06	194	76	6	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	PTPRM RGS5 SYNE1 ANXA3 SYNE2 SEC14L1	1.04e-06	195	76	6	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SYNE2 XRN1 GOLGA8B RNF213 GOLGA8A	1.11e-06	197	76	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	PTPRM RGS5 SYNE1 ANXA3 SYNE2 SEC14L1	1.11e-06	197	76	6	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PTPRM SYNE2 RNF213 CHD7 FAM124B SEC14L1	1.21e-06	200	76	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L SYNE1 SYNE2 XRN1 RNF213 ATG2A	1.21e-06	200	76	6	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	SAMD9L PTPRM RGS5 SYNE2 XRN1 RNF213	1.21e-06	200	76	6	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SAMD9L PTPRM SYNE2 XRN1 RNF213 DYNC1H1	1.21e-06	200	76	6	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RNF213 CHD2 GOLGA8A DYNC1H1 EPM2AIP1	5.33e-06	147	76	5	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	CF-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	ANXA3 SYNE2 ATG2A SEC14L1 TG	1.24e-05	175	76	5	8020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCell	facs-Marrow-B-cells-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPF SYNE1 ANXA3 SYNE2 IQGAP3	1.50e-05	182	76	5	9025178ede571e3808d4657ad4892152f336c9b4
ToppCell	facs-Marrow-B-cells-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPF SYNE1 ANXA3 SYNE2 IQGAP3	1.50e-05	182	76	5	c075756cd4bb484ede1be2bcdb9eac60eab0573a
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L XRN1 CHD2 IQGAP1	1.50e-05	182	76	5	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	droplet-Spleen-nan-18m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L XRN1 CHD2 IQGAP1	1.54e-05	183	76	5	28cbf909424f3be4491d49832f0aca0386560814
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SAMD9L SYNE2 XRN1 RNF213 CHD2	1.54e-05	183	76	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L XRN1 CHD2 IQGAP1	1.54e-05	183	76	5	3fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SH3RF2 ANXA3 GOLGA8B GOLGA8A HOMER1	1.62e-05	185	76	5	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD9L XRN1 PKHD1 RNF213 CHD2	1.62e-05	185	76	5	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L XRN1 SYK IQGAP1	1.62e-05	185	76	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SH3RF2 ANXA3 GOLGA8B GOLGA8A HOMER1	1.71e-05	187	76	5	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRM SYNE1 ANXA3 SYNE2 SEC14L1	1.80e-05	189	76	5	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 SYNE2 GOLGA8B ATG2A GOLGA8A	1.85e-05	190	76	5	05e6af222d0ad97cb69f399a96c9038f9dd989b9
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L CSNK2A1 SYNE2 IQGAP1	1.89e-05	191	76	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANXA3 PKHD1 GRB14 GOLGA8B GOLGA8A	1.89e-05	191	76	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	PTPRM SYNE1 ANXA3 SYNE2 SEC14L1	1.89e-05	191	76	5	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L CSNK2A1 SYNE2 IQGAP1	1.89e-05	191	76	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SAMD9L CSNK2A1 SYNE2 IQGAP1	1.89e-05	191	76	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE2 RNF213 CHD2 SFI1 GOLGA8A	1.94e-05	192	76	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	PTPRM SYNE1 ANXA3 SYNE2 SEC14L1	1.94e-05	192	76	5	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CENPF SYK PKHD1 GRB14 IQGAP3	2.04e-05	194	76	5	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ANXA3 SYNE2 PKHD1 RNF213	2.04e-05	194	76	5	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRM RGS5 RAI14 HERC2P3 SEC14L1	2.04e-05	194	76	5	ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCell	COVID-19_Severe-CD8+_Tem\|World / disease group, cell group and cell class	PTPRM SYNE1 SYNE2 RNF213 ATG2A	2.04e-05	194	76	5	60aa16e166894e3fcd82f7a54607c2c02e55b614
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRM RGS5 RAI14 HERC2P3 SEC14L1	2.04e-05	194	76	5	cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SYNE2 GOLGA8B CHD2 ZNF101 GOLGA8A	2.09e-05	195	76	5	4bdedd924564a260841a9153604026b57487c83d
ToppCell	COVID-19_Severe-CD8+_Tem\|COVID-19_Severe / Disease condition and Cell class	PTPRM SYNE1 SYNE2 RNF213 ATG2A	2.09e-05	195	76	5	ff7ae62393e1c858a10592db8e6d9f36b8bae396
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	PTPRM SYNE1 ANXA3 SYNE2 SEC14L1	2.09e-05	195	76	5	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	PTPRM SYNE1 ANXA3 SYNE2 SEC14L1	2.09e-05	195	76	5	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN PTPRM SYNE1 ANXA3 SEC14L1	2.14e-05	196	76	5	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN PTPRM SYNE1 ANXA3 SEC14L1	2.14e-05	196	76	5	48b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN PTPRM SYNE1 ANXA3 SEC14L1	2.14e-05	196	76	5	473980c827443464d08a0be28c53e3536369b12a
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD9L SYNE1 SYNE2 RNF213 ATG2A	2.14e-05	196	76	5	17f17edadafdad9f24e88d708d7e1c765503131c
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SYNE1 SYNE2 GOLGA8B CHD2 GOLGA8A	2.20e-05	197	76	5	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_Tem\|COVID-19_Severe / Disease group, lineage and cell class	PTPRM SYNE1 SYNE2 RNF213 ATG2A	2.20e-05	197	76	5	f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SH3RF2 ANXA3 GOLGA8B GOLGA8A HOMER1	2.20e-05	197	76	5	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating2_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CENPF RGS5 ANXA3 FAM124B IQGAP3	2.20e-05	197	76	5	8e655db7c6f04d49927a1f0a75178e5955b4af08
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SYNE2 PKHD1 CHD7 PHIP HOMER1	2.20e-05	197	76	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Naive_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	GOLGA8B CHD7 SFI1 ZNF101 GOLGA8A	2.20e-05	197	76	5	836dd8110d5689f944ad1d301def38c32278b5b5
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	PTPRM SYNE1 ANXA3 SYNE2 SEC14L1	2.20e-05	197	76	5	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 SYNE2 RNF213 ATG2A GOLGA8A	2.25e-05	198	76	5	a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCell	systemic_lupus_erythematosus-treated\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9L SYNE1 SYNE2 XRN1 RNF213	2.25e-05	198	76	5	8165ff735095c52994fb5057d89be93cc378b7da
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ANPEP SYNE1 SYNE2 ATG2A IQGAP1	2.25e-05	198	76	5	e76061e66f6d60f5735962aa7777dda8958caed9
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 SYNE2 RNF213 ATG2A GOLGA8A	2.25e-05	198	76	5	76aff381403bc5a8a9cc73eb1e5dbdc0bac7de6c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 SYNE2 RNF213 ATG2A GOLGA8A	2.25e-05	198	76	5	a781fd35a7cda8b7760c2e3ddccaac7aac26c979
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 SYNE2 RNF213 ATG2A GOLGA8A	2.25e-05	198	76	5	df399674345c45738d765a8354ea8d1484572c34
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 SYNE2 GOLGA8B CHD7 GOLGA8A	2.25e-05	198	76	5	a3bd099ef0e606c2da690a6fcf6f79e9360c9c9f
ToppCell	COVID-19_Mild-Lymphoid_T/NK-gd_T\|COVID-19_Mild / Disease group, lineage and cell class	SYNE1 SYNE2 RNF213 ATG2A GOLGA8A	2.25e-05	198	76	5	6aea5d00c417708f05b6d2dfe5a962d80864f8eb
ToppCell	healthy_donor-Lymphocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNE1 SYNE2 GOLGA8B RNF213 GOLGA8A	2.30e-05	199	76	5	2841e16d54acd344ba454f024e285c28abc37319
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SYNE2 GOLGA8B RNF213 GOLGA8A	2.30e-05	199	76	5	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	COVID-19_Severe-immature_Neutrophil\|COVID-19_Severe / Disease condition and Cell class	CENPF SYNE1 ANXA3 SYNE2 CHD7	2.30e-05	199	76	5	f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCell	Control-NK\|Control / Disease condition and Cell class	SYNE1 SYNE2 SYK RNF213 IQGAP1	2.30e-05	199	76	5	f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	SAMD9L SYNE1 SYNE2 XRN1 RNF213	2.30e-05	199	76	5	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	COVID-19_Severe-immature_Neutrophil-\|COVID-19_Severe / Disease condition and Cell class	CENPF SYNE1 ANXA3 SYNE2 CHD7	2.30e-05	199	76	5	42ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PTPRM SYNE2 RNF213 DYNC1H1 SEC14L1	2.36e-05	200	76	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-gd_T\|COVID-19_Mild / Disease, condition lineage and cell class	SYNE1 SYNE2 RNF213 ATG2A GOLGA8A	2.36e-05	200	76	5	6560753d3df2f87860b52052d4881aa45410f666
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	ANPEP ANXA3 IQGAP3 IQGAP1 SEC14L1	2.36e-05	200	76	5	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_Tem\|COVID-19_Severe / Disease, condition lineage and cell class	PTPRM SYNE1 SYNE2 RNF213 ATG2A	2.36e-05	200	76	5	31859b8db7ea17e48b7b54e92f0d76aeb755e7ca
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PTPRM SYNE2 RNF213 DYNC1H1 SEC14L1	2.36e-05	200	76	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SAMD9L PTPRM SYNE2 RNF213 DYNC1H1	2.36e-05	200	76	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PTPRM RGS5 RNF213 FAM124B SEC14L1	2.36e-05	200	76	5	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PTPRM RGS5 RNF213 FAM124B SEC14L1	2.36e-05	200	76	5	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	SYNE2 XRN1 RNF213 DYNC1H1 IQGAP1	2.36e-05	200	76	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SAMD9L RGS5 SYNE2 RNF213 SEC14L1	2.36e-05	200	76	5	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	SYNE1 SYNE2 RNF213 GOLGA8A	5.50e-05	121	76	4	19333a660800b583fa27b495c1f7828e6636a257
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CENPF C7orf57 KISS1 IQGAP3	6.44e-05	126	76	4	8ae631694bbba40f64e55e2be8162d7a40eeadc5
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANXA3 PKHD1 IQGAP3 SEC14L1	6.84e-05	128	76	4	58639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ANXA3 PKHD1 IQGAP3 SEC14L1	6.84e-05	128	76	4	9b3c57d559a5ed8d590dd89b64a57a3227d8c684
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRM SYNE1 SYNE2 SEC14L1	1.11e-04	145	76	4	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	COVID-19_Moderate-multiplets\|COVID-19_Moderate / disease group, cell group and cell class	SH3RF2 SYNE1 SYNE2 GOLGA8B	1.17e-04	147	76	4	baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CENPF MCIDAS C7orf57 IQGAP3	1.23e-04	149	76	4	a6406c4c9404271a2f4c615c6cd3265b2d759b12
ToppCell	MS-CD4-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	SAMD9L SYNE2 RNF213 TG	1.33e-04	152	76	4	b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE2 GOLGA8B ZNF101 GOLGA8A	1.36e-04	153	76	4	7480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE2 GOLGA8B ZNF101 GOLGA8A	1.47e-04	156	76	4	53ded973358e3e48054130131e959f0d1f4ef60f
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	SYNE2 RNF213 RICTOR GOLGA8A	1.47e-04	156	76	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 SYK SFI1 IQGAP1	1.51e-04	157	76	4	ec433d2fe827abdb647be4176c231b7052482b6f
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SYNE1 SYNE2 CHD2 DYNC1H1	5.40e-05	49	46	4	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Disease	sucrose liking measurement	RELN GOLGA8B GOLGA8A	1.74e-05	20	75	3	EFO_0010157
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	3.81e-05	4	75	2	cv:CN293514
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	6.34e-05	5	75	2	C1450051
Disease	sleep efficiency	GOLGA8B GOLGA8A	6.34e-05	5	75	2	EFO_0803364
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	6.34e-05	5	75	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	9.50e-05	6	75	2	cv:C0410189
Disease	Lennox-Gastaut syndrome	CHD2 MAPK10	9.50e-05	6	75	2	C0238111
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	9.50e-05	6	75	2	C0410189
Disease	CHARGE syndrome (implicated_via_orthology)	CHD2 CHD7	1.33e-04	7	75	2	DOID:0050834 (implicated_via_orthology)
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.33e-04	7	75	2	C0751337
Disease	ankylosing spondylitis (is_marker_for)	TLR5 CRP	2.83e-04	10	75	2	DOID:7147 (is_marker_for)
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	4.14e-04	12	75	2	DOID:11726 (implicated_via_orthology)
Disease	Libman-Sacks Disease	ANXA3 TLR5 CRP	4.40e-04	58	75	3	C0242380
Disease	Unipolar Depression	RELN ANPEP HOMER1 CRP TG	5.24e-04	259	75	5	C0041696
Disease	Lupus Erythematosus, Systemic	ANXA3 TLR5 CRP	7.96e-04	71	75	3	C0024141
Disease	Moyamoya Disease	NF1 RNF213	8.46e-04	17	75	2	C0026654
Disease	Familial Progressive Myoclonic Epilepsy	CHD2 TBC1D24	8.46e-04	17	75	2	C0751777
Disease	Atypical Inclusion-Body Disease	CHD2 TBC1D24	8.46e-04	17	75	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	CHD2 TBC1D24	8.46e-04	17	75	2	C0751778
Disease	Biotin-Responsive Encephalopathy	CHD2 TBC1D24	8.46e-04	17	75	2	C0751780
Disease	May-White Syndrome	CHD2 TBC1D24	8.46e-04	17	75	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	CHD2 TBC1D24	8.46e-04	17	75	2	C0751781
Disease	Action Myoclonus-Renal Failure Syndrome	CHD2 TBC1D24	9.50e-04	18	75	2	C0751779
Disease	basophil percentage of granulocytes	CHD7 ZNF101 IQGAP1	1.25e-03	83	75	3	EFO_0007995
Disease	Autism Spectrum Disorders	RELN CHD2 IQGAP3	1.34e-03	85	75	3	C1510586
Disease	testosterone measurement	PDE4A NF1 RGS5 SYNE2 GRB14 CHD7 MAPK10 KISS1 PHIP IQGAP1	1.41e-03	1275	75	10	EFO_0004908
Disease	Down syndrome (is_marker_for)	RELN ERCC2	1.42e-03	22	75	2	DOID:14250 (is_marker_for)
Disease	Carcinoma of lung	RICTOR CSNK2A3	1.56e-03	23	75	2	C0684249
Disease	macular degeneration (is_implicated_in)	ERCC2 CRP	2.15e-03	27	75	2	DOID:4448 (is_implicated_in)
Disease	non-high density lipoprotein cholesterol measurement	FAM187B PDE4A TAMM41 SYNE2 XRN1 GRB14 CHD7	2.24e-03	713	75	7	EFO_0005689

Protein segments in the cluster

Peptide	Gene	Start	Entry
KQQADDLQWYHQELG	CCDC96	296	Q2M329
DLQWYHQELGQLKRQ	CCDC96	301	Q2M329
KQDAQILYKAGENRW	ANXA3	176	P12429
LYEGLDWLANQLKNK	ARF3	166	P61204
QQQDYWLIDVRAQND	ANPEP	596	P15144
DLQGLWQELYQLQAK	CCDC197	21	Q8NCU1
RKQQLQQEQWYLESL	CCDC121	226	Q6ZUS5
NATDGNVVRNKQWLY	CCDC163	16	A0A0D9SF12
NKLREYQLEGVNWLL	CHD7	966	Q9P2D1
GYALNEWLQDIRKNQ	ATG2A	1726	Q2TAZ0
RGLQQQNSDWYLKQL	IQGAP1	336	P46940
LSWLKEYQQNNDIGE	CHML	56	P26374
WNKNDDRLLQAVENG	RAI14	16	Q9P0K7
FLYQKLIGWLNEDQR	LTN1	661	O94822
LSRLEEEYQIQKWGN	ATPAF2	236	Q8N5M1
RDYIDQWNKVIEQLG	MAPK10	266	P53779
REQNLQDDLDWYQAL	GPR158	146	Q5T848
NLIREYVKQTWNLQG	SYK	126	P43405
AQELENLNKWGLNIF	PDE4A	366	P27815
DDKYNIGIIEENWQL	EEF1AKMT1	36	Q8WVE0
VLVQREKDLPNYNWN	KISS1	101	Q15726
SWYEQGILENIQRNK	ERCC2	551	P18074
SIYQNLQELKQKGRW	FAM161B	66	Q96MY7
KWPNVNLRNYKDEQL	RICTOR	556	Q6R327
WKQQLAAYQEEAERL	HOMER1	211	Q86YM7
ADWYLEQLNSDREQK	IQGAP3	331	Q86VI3
YWKEVADQNQRALGD	MCIDAS	181	D6RGH6
RDKQLYAWNEGNQII	OLFML1	376	Q6UWY5
FQWKQENLRVGEVYE	RELN	326	P78509
VEWGNQDDYQLVRKL	CSNK2A3	31	Q8NEV1
WQTQDYDGNKILLQV	FAM124B	231	Q9H5Z6
DCLRKQYLSENEQWQ	CENPF	1596	P49454
NLELRDYQLEGLNWL	CHD2	481	O14647
RSLEQKNNPDYNWNV	CHD2	1811	O14647
QANTNLWNEYRIKDL	EPM2AIP1	511	Q7L775
LISNGYKDEWLQQQQ	C7orf57	216	Q8NEG2
RKWGVQDVNQDNYID	FUT10	371	Q6P4F1
NVLNWRALKYEVQGE	CRP	201	P02741
VEWGNQDDYQLVRKL	CSNK2A1	31	P68400
ENIYNRLGEDLNKWQ	DYNC1H1	1066	Q14204
NWGIEEENKLYFRKN	GRB14	176	Q14449
EWQQLDSAQKNLYRD	KRBOX4	21	Q5JUW0
WNKNGRQVVQYEIDF	FAM187B	96	Q17R55
DQYAEQIKGERAQWQ	GOLGA8B	231	A8MQT2
NVQLIDKVWQLGRDY	SEC14L1	591	Q92503
KLIRQVDKWQEEYNG	PTPRM	1366	P28827
LDLKEDYNQWNNLIE	PAFAH2	361	Q99487
YAEQIKGERAQWQQR	GOLGA8A	261	A7E2F4
KARLQWALQAYQGQL	SFI1	871	A8K8P3
WLYLQDQNKAADAVG	SYT12	271	Q8IV01
WRENAVRLNEKNYEL	ATP6V1H	376	Q9UI12
VISQWNDYVERKNQL	SYNE1	2731	Q8NF91
ELWIYLQDADQQLQN	SYNE1	4141	Q8NF91
WDEEIENLKQILNNY	SYNE2	4001	Q8WXH0
WRDSLDKLLQNNYGL	RGS5	61	O15539
KWVNEDLKINEQYGQ	SAMD9L	21	Q8IVG5
NYSEDEQNGKQKWRE	NANOGNB	51	Q7Z5D8
NNIFYILLRDWGQNE	POLR3A	661	O14802
YERLLQQDNGMDWLN	SETD1B	1701	Q9UPS6
YISAWELQRKDQLQQ	WDR18	61	Q9BV38
TGNWKEGQEQLLRYQ	PKHD1	3996	P08F94
QWNGLINKYINSQLR	HERC2P3	871	Q9BVR0
ELQELKQLARQGYWA	TBC1D24	31	Q9ULP9
GQAQLWTDLQYREKE	RNF213	571	Q63HN8
DLLQQQVLNSGWKLY	ZNF749	166	O43361
QEEWQQLDPAQRLLY	ZNF334	21	Q9HCZ1
QQFDDAKYRRWNIGD	PHIP	1056	Q8WWQ0
YQINQNGEVRLEKQW	XRN1	806	Q8IZH2
LWNNQEKIGQYLSSN	NF1	1511	P21359
DLLNWNNLYIAGRLQ	TAMM41	121	Q96BW9
QWKDQDIENLYQNLG	ZNF101	46	Q8IZC7
RQLDENWYQGEINGI	SH3RF2	156	Q8TEC5
EWQQLDSAQKNLYRD	ZNF674	21	Q2M3X9
QKQQYLRWPEDFQDV	TLR5	811	O60602
VFELYQRWEAQNKGQ	TG	781	P01266
QRDGKYRWEEEQLQL	TCHH	1816	Q07283
YLQWEIGNKNLTLDQ	TRMT10C	341	Q7L0Y3
DRYNWQRQENDKLGT	ZNF106	276	Q9H2Y7
IKLYQDQLQKWIRGN	TOR1B	151	O14657
QWRGLNEAAIKNVYL	MYOM1	1086	P52179