Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein light intermediate chain binding	HOOK2 RILPL1 DNAH14	8.84e-05	28	62	3	GO:0051959
GeneOntologyMolecularFunction	thioesterase binding	TRAF1 TRAF2	4.20e-04	10	62	2	GO:0031996
GeneOntologyBiologicalProcess	protein polyubiquitination	AMFR TRAF1 TRAF2 BRCA1 TRIM26 RNF213 RNF170	2.51e-05	289	62	7	GO:0000209
Domain	GRIP_dom	GCC2 TRIP11 GOLGA4	7.50e-06	12	62	3	IPR000237
Domain	GRIP	GCC2 TRIP11 GOLGA4	7.50e-06	12	62	3	PS50913
Domain	TRAF_BIRC3-bd	TRAF1 TRAF2	1.08e-05	2	62	2	IPR032070
Domain	TRAF_BIRC3_bd	TRAF1 TRAF2	1.08e-05	2	62	2	PF16673
Domain	Znf_C3HC4_RING-type	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	2.24e-05	172	62	6	IPR018957
Domain	zf-C3HC4	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	9.53e-05	223	62	6	PF00097
Domain	TNF_rcpt--assoc_TRAF	TRAF1 TRAF2	1.61e-04	6	62	2	IPR012227
Domain	ZF_RING_2	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	4.56e-04	298	62	6	PS50089
Domain	-	GCC2 GOLGA4	4.80e-04	10	62	2	1.10.220.60
Domain	RING	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	5.15e-04	305	62	6	SM00184
Domain	Grip	GCC2 GOLGA4	5.85e-04	11	62	2	SM00755
Domain	GRIP	GCC2 GOLGA4	5.85e-04	11	62	2	PF01465
Domain	MATH/TRAF_dom	TRAF1 TRAF2	7.00e-04	12	62	2	IPR002083
Domain	MATH	TRAF1 TRAF2	7.00e-04	12	62	2	PS50144
Domain	MATH	TRAF1 TRAF2	7.00e-04	12	62	2	SM00061
Domain	MATH	TRAF1 TRAF2	7.00e-04	12	62	2	PF00917
Domain	Znf_RING	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	7.30e-04	326	62	6	IPR001841
Domain	-	TRAF1 TRAF2	9.62e-04	14	62	2	2.60.210.10
Domain	PH	IQSEC2 PLEKHA2 PLEKHA7 RASAL1 EXOC8	2.28e-03	278	62	5	SM00233
Domain	PH_DOMAIN	IQSEC2 PLEKHA2 PLEKHA7 RASAL1 EXOC8	2.32e-03	279	62	5	PS50003
Domain	PH_domain	IQSEC2 PLEKHA2 PLEKHA7 RASAL1 EXOC8	2.35e-03	280	62	5	IPR001849
Domain	ZF_RING_1	AMFR TRAF2 BRCA1 TRIM26 RNF170	2.78e-03	291	62	5	PS00518
Domain	TRAF-like	TRAF1 TRAF2	2.85e-03	24	62	2	IPR008974
Domain	-	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	3.68e-03	449	62	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	4.10e-03	459	62	6	IPR013083
Domain	DEAD_ATP_HELICASE	DDX3Y DDX4	4.74e-03	31	62	2	PS00039
Domain	RNA-helicase_DEAD-box_CS	DDX3Y DDX4	5.36e-03	33	62	2	IPR000629
Domain	Myb_DNA-binding	RERE MYBL2	6.01e-03	35	62	2	PF00249
Domain	Q_MOTIF	DDX3Y DDX4	6.70e-03	37	62	2	PS51195
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRAF2 TCHH ACAD11 BRCA1 SFSWAP PCDH19 MTR RNF213 NUP188 RERE PPFIA3 SKIL	6.63e-07	1116	63	12	31753913
Pubmed	Prognostic Significance of TNFR-Associated Factor 1 and 2 (TRAF1 and TRAF2) in Glioblastoma.	TRAF1 TRAF2	3.23e-06	2	63	2	28926524
Pubmed	Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling.	TRAF1 TRAF2	3.23e-06	2	63	2	12370254
Pubmed	Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway.	TRAF2 BRCA1	3.23e-06	2	63	2	22167321
Pubmed	Expression of the tumor necrosis factor receptor-associated factors 1 and 2 and regulation of the nuclear factor-kappaB antiapoptotic activity in human gliomas.	TRAF1 TRAF2	3.23e-06	2	63	2	16304992
Pubmed	Gene expression of tumor necrosis factor receptor associated-factor (TRAF)-1 and TRAF-2 in inflammatory bowel disease.	TRAF1 TRAF2	3.23e-06	2	63	2	23414308
Pubmed	Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.	DDX3Y SKIL PSPC1 DDX4	6.09e-06	65	63	4	18729074
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	WBP11 NFATC3 IQSEC2 ZNFX1 JAKMIP3 SSH2 PPFIA3 TRIP11 GOLGA4 RASAL1	8.55e-06	963	63	10	28671696
Pubmed	A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.	TRAF1 TRAF2	9.68e-06	3	63	2	8069916
Pubmed	Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation.	TRAF1 TRAF2	9.68e-06	3	63	2	14557256
Pubmed	Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.	TRAF1 TRAF2	9.68e-06	3	63	2	16622006
Pubmed	Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus.	TRAF1 TRAF2	9.68e-06	3	63	2	20815704
Pubmed	Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.	TRAF1 TRAF2	9.68e-06	3	63	2	9151858
Pubmed	TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.	TRAF1 TRAF2	9.68e-06	3	63	2	29748372
Pubmed	T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.	TRAF1 TRAF2	9.68e-06	3	63	2	8627180
Pubmed	Loss of the HPV-infection resistance EVER2 protein impairs NF-κB signaling pathways in keratinocytes.	TRAF1 TRAF2	9.68e-06	3	63	2	24586810
Pubmed	The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.	TRAF1 TRAF2	9.68e-06	3	63	2	8692885
Pubmed	Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A.	TRAF1 TRAF2	9.68e-06	3	63	2	25766329
Pubmed	Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex.	TRAF1 TRAF2	9.68e-06	3	63	2	28155233
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WBP11 TRAF2 IQSEC2 TTC17 ZNFX1 JAKMIP3 RILPL1 SKIL FUT8 TRIP11 RYR3	1.77e-05	1285	63	11	35914814
Pubmed	Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B.	TRAF1 TRAF2	1.93e-05	4	63	2	9464265
Pubmed	TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.	TRAF1 TRAF2	1.93e-05	4	63	2	10903733
Pubmed	Asymmetric recruitment of cIAPs by TRAF2.	TRAF1 TRAF2	1.93e-05	4	63	2	20447407
Pubmed	Crystallographic analysis of CD40 recognition and signaling by human TRAF2.	TRAF1 TRAF2	1.93e-05	4	63	2	10411888
Pubmed	Glucocorticoid-induced TNF receptor, a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-kappa B activation.	TRAF1 TRAF2	1.93e-05	4	63	2	15944293
Pubmed	Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.	TRAF1 TRAF2	1.93e-05	4	63	2	9500555
Pubmed	Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.	NFATC3 ALOX15	1.93e-05	4	63	2	28724635
Pubmed	Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.	TRAF1 TRAF2	1.93e-05	4	63	2	20385093
Pubmed	A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.	TRAF1 TRAF2	1.93e-05	4	63	2	11804591
Pubmed	NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27.	TRAF1 TRAF2	1.93e-05	4	63	2	9794406
Pubmed	CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.	TRAF1 TRAF2	1.93e-05	4	63	2	9607925
Pubmed	CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins.	TRAF1 TRAF2	1.93e-05	4	63	2	8662842
Pubmed	Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers.	BRCA1 MTR	1.93e-05	4	63	2	17151928
Pubmed	Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling.	TRAF1 TRAF2	1.93e-05	4	63	2	20856938
Pubmed	The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex.	TRAF1 TRAF2	1.93e-05	4	63	2	10544141
Pubmed	The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.	GCC2 GOLGA4	1.93e-05	4	63	2	15654769
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NFATC3 RASSF2 IQSEC2 HJURP PLEKHA2 SSH2 PLEKHA7 TRIP11 GOLGA4	2.40e-05	861	63	9	36931259
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	AMFR TRAF2 RNF213 RNF170	2.75e-05	95	63	4	29643511
Pubmed	Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis.	TRAF1 TRAF2	3.22e-05	5	63	2	12411322
Pubmed	TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.	TRAF1 TRAF2	3.22e-05	5	63	2	17332487
Pubmed	Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.	TRAF1 TRAF2	3.22e-05	5	63	2	10037686
Pubmed	The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.	TRAF1 TRAF2	3.22e-05	5	63	2	8548810
Pubmed	The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B.	AMFR BAG6	3.22e-05	5	63	2	33241194
Pubmed	Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins.	TRAF1 TRAF2	3.22e-05	5	63	2	8702708
Pubmed	Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.	TRAF1 TRAF2	3.22e-05	5	63	2	10523854
Pubmed	Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer.	BRCA1 MTR	3.22e-05	5	63	2	18842997
Pubmed	TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.	TRAF1 TRAF2	3.22e-05	5	63	2	9104814
Pubmed	Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.	TRAF1 TRAF2	3.22e-05	5	63	2	9507120
Pubmed	TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.	TRAF1 TRAF2	3.22e-05	5	63	2	10809768
Pubmed	Expression of TNF-receptor-associated factor genes in murine tooth development.	TRAF1 TRAF2	3.22e-05	5	63	2	12711536
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TRAF2 GCC2 TRIP11 BAG6 CTTNBP2NL	4.23e-05	212	63	5	33853758
Pubmed	Defining the membrane proteome of NK cells.	AMFR SYNE3 GCC2 NVL RNF213 DDX3Y NUP188 FUT8 BAG6 EXOC8	4.45e-05	1168	63	10	19946888
Pubmed	The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.	TRAF1 TRAF2	4.82e-05	6	63	2	16891304
Pubmed	The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.	TRAF1 TRAF2	4.82e-05	6	63	2	11384837
Pubmed	The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.	TRAF1 TRAF2	4.82e-05	6	63	2	10837247
Pubmed	Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi.	GCC2 GOLGA4	4.82e-05	6	63	2	12972563
Pubmed	Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).	TRAF1 TRAF2	4.82e-05	6	63	2	11435475
Pubmed	Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase.	TRAF1 TRAF2	4.82e-05	6	63	2	10025951
Pubmed	Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.	TRAF1 TRAF2	4.82e-05	6	63	2	9488716
Pubmed	Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.	TRAF1 TRAF2	4.82e-05	6	63	2	15084608
Pubmed	TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.	TRAF1 TRAF2	4.82e-05	6	63	2	8565075
Pubmed	Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.	TRAF1 TRAF2	4.82e-05	6	63	2	9275204
Pubmed	Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.	TRAF1 TRAF2	4.82e-05	6	63	2	9168896
Pubmed	BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.	TRAF1 TRAF2	4.82e-05	6	63	2	20138174
Pubmed	Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.	TRAF1 TRAF2	4.82e-05	6	63	2	9705938
Pubmed	The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily.	TRAF1 TRAF2	4.82e-05	6	63	2	9852070
Pubmed	TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.	TRAF1 TRAF2	4.82e-05	6	63	2	15383523
Pubmed	Inducible tumor necrosis factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulation.	TRAF1 TRAF2	4.82e-05	6	63	2	23543740
Pubmed	Tumor necrosis factor receptor-associated factors (TRAFs).	TRAF1 TRAF2	4.82e-05	6	63	2	11607847
Pubmed	I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.	TRAF1 TRAF2	4.82e-05	6	63	2	8710854
Pubmed	The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.	TRAF1 TRAF2	4.82e-05	6	63	2	8943045
Pubmed	Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.	TRAF1 TRAF2	4.82e-05	6	63	2	9177772
Pubmed	Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death.	TRAF1 TRAF2	4.82e-05	6	63	2	11181075
Pubmed	BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.	TRAF2 BAG6	4.82e-05	6	63	2	36045679
Pubmed	TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.	TRAF1 TRAF2	4.82e-05	6	63	2	8612133
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	WBP11 RADX NVL MTR RNF213 TTC17 GOLGA4 MYBL2	5.22e-05	733	63	8	34672954
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	AMFR ACAD11 TRIM26 TTC17 HOOK2 NUP188 FUT8 BAG6 EXOC8	6.23e-05	974	63	9	28675297
Pubmed	A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.	AMFR BAG6	6.74e-05	7	63	2	23665563
Pubmed	A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.	TRAF1 TRAF2	6.74e-05	7	63	2	11728344
Pubmed	TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes.	TRAF1 TRAF2	6.74e-05	7	63	2	23918987
Pubmed	Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization.	TRAF1 TRAF2	6.74e-05	7	63	2	26969755
Pubmed	4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.	TRAF1 TRAF2	6.74e-05	7	63	2	9418902
Pubmed	Modulation of life and death by the TNF receptor superfamily.	TRAF1 TRAF2	6.74e-05	7	63	2	9916988
Pubmed	Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.	TRAF1 TRAF2	6.74e-05	7	63	2	9162022
Pubmed	Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.	TRAF1 TRAF2	6.74e-05	7	63	2	29875129
Pubmed	The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells.	TRAF1 TRAF2	6.74e-05	7	63	2	15941918
Pubmed	Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation.	TRAF1 TRAF2	6.74e-05	7	63	2	19287455
Pubmed	The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.	TRAF1 TRAF2	6.74e-05	7	63	2	9774460
Pubmed	CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.	TRAF1 TRAF2	6.74e-05	7	63	2	9718306
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 TRIM26 GCC2 RNF213 PLEKHA2 TTC17 HOOK2 RERE RILPL1 DNAH14 GOLGA4	6.77e-05	1489	63	11	28611215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TRAF2 TRIM26 MTR RNF213 TTC17 NUP188 RERE PSPC1 TRIP11 BAG6 DDX4	7.06e-05	1496	63	11	32877691
Pubmed	USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.	NCBP2 TRAF2 NUP188	8.68e-05	47	63	3	33903120
Pubmed	Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.	TRAF1 TRAF2	8.98e-05	8	63	2	19795416
Pubmed	ASK1 is essential for JNK/SAPK activation by TRAF2.	TRAF1 TRAF2	8.98e-05	8	63	2	9774977
Pubmed	USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue.	TRAF1 TRAF2	8.98e-05	8	63	2	31666375
Pubmed	TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.	TRAF1 TRAF2	8.98e-05	8	63	2	11907583
Pubmed	Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634.	TRAF1 TRAF2	8.98e-05	8	63	2	36185580
Pubmed	Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.	TRAF1 TRAF2	8.98e-05	8	63	2	11278268
Pubmed	Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.	AMFR BAG6	8.98e-05	8	63	2	27387505
Pubmed	The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.	TRAF1 TRAF2	8.98e-05	8	63	2	12529173
Interaction	CDK18 interactions	TRAF1 TRAF2 KRT40 MTR HOOK2 BAG6	3.37e-06	131	63	6	int:CDK18
Interaction	CCDC198 interactions	TRAF1 TRAF2 KRT40 HOOK2	4.22e-06	35	63	4	int:CCDC198
Interaction	CCHCR1 interactions	TRAF1 TRAF2 SYNE3 KRT40 HOOK2 PLEKHA7 EXOC8	7.19e-06	229	63	7	int:CCHCR1
Interaction	RBM41 interactions	TRAF1 TRAF2 KRT40 HOOK2	8.05e-06	41	63	4	int:RBM41
Interaction	ZNF844 interactions	TRAF1 KRT40 HOOK2	1.03e-05	14	63	3	int:ZNF844
Interaction	ZC2HC1C interactions	TRAF1 TRAF2 KRT40 HOOK2 CTTNBP2NL	1.52e-05	100	63	5	int:ZC2HC1C
Interaction	UTP14C interactions	TRAF1 TRAF2 KRT40 HOOK2	1.79e-05	50	63	4	int:UTP14C
Interaction	BEX2 interactions	TRAF1 TRAF2 ACAD11 KRT40 EXOC8	2.02e-05	106	63	5	int:BEX2
Interaction	RASSF5 interactions	TRAF1 TRAF2 RASSF2 KRT40	2.10e-05	52	63	4	int:RASSF5
Interaction	ANKRD36BP1 interactions	TRAF2 KRT40 HOOK2	3.72e-05	21	63	3	int:ANKRD36BP1
Interaction	PIP4P1 interactions	NFATC3 RNF213 ZNFX1 RILPL1	7.61e-05	72	63	4	int:PIP4P1
Interaction	TSGA10IP interactions	TRAF2 BRCA1 SZT2 KRT40 HOOK2	7.66e-05	140	63	5	int:TSGA10IP
Interaction	FAM107A interactions	TRAF2 KRT40 DDX3Y HOOK2	8.03e-05	73	63	4	int:FAM107A
Interaction	C2CD6 interactions	TRAF1 TRAF2 BRCA1 KRT40	8.92e-05	75	63	4	int:C2CD6
Interaction	TCEA2 interactions	TRAF1 TRAF2 BRCA1 KRT40 HOOK2	1.39e-04	159	63	5	int:TCEA2
Interaction	FLYWCH1 interactions	TRAF2 BRCA1 HOOK2	1.49e-04	33	63	3	int:FLYWCH1
Interaction	FBF1 interactions	TRAF1 TRAF2 SYNE3 TRIM26 KRT40	1.96e-04	171	63	5	int:FBF1
Interaction	EXOC3-AS1 interactions	TRAF2 KRT40	2.00e-04	7	63	2	int:EXOC3-AS1
Interaction	ARSJ interactions	TRAF1 TRAF2	2.00e-04	7	63	2	int:ARSJ
Interaction	LIN37 interactions	TRAF1 KRT40 HJURP MYBL2	2.06e-04	93	63	4	int:LIN37
Interaction	CEP57L1 interactions	TRAF2 BRCA1 KRT40 EXOC8	2.23e-04	95	63	4	int:CEP57L1
Interaction	KANSL1 interactions	TRAF1 TRAF2 HOOK2 RERE	2.32e-04	96	63	4	int:KANSL1
Interaction	THAP7 interactions	TRAF1 TRAF2 TRIM26 KRT40	2.42e-04	97	63	4	int:THAP7
Interaction	CWF19L2 interactions	TRAF2 BRCA1 KRT40 HOOK2 EXOC8	2.62e-04	182	63	5	int:CWF19L2
Interaction	ZMYM5 interactions	TRAF2 ACAD11 SKIL	2.65e-04	40	63	3	int:ZMYM5
Interaction	PIMREG interactions	ACAD11 KRT40 HOOK2	2.65e-04	40	63	3	int:PIMREG
Interaction	TMC8 interactions	TRAF1 TRAF2	2.66e-04	8	63	2	int:TMC8
Interaction	NOL4L-DT interactions	TRAF1 KRT40	2.66e-04	8	63	2	int:NOL4L-DT
Interaction	DTNB interactions	TRAF2 KRT40 PLEKHA2 GOLGA4	2.82e-04	101	63	4	int:DTNB
Interaction	ZNF35 interactions	TRAF2 HOOK2 EXOC8	2.85e-04	41	63	3	int:ZNF35
GeneFamily	Ring finger proteins	AMFR TRAF2 BRCA1 TRIM26 RNF213 RNF170	6.59e-05	275	46	6	58
GeneFamily	TNF receptor associated factors	TRAF1 TRAF2	1.32e-04	7	46	2	1056
GeneFamily	DEAD-box helicases	DDX3Y DDX4	5.11e-03	42	46	2	499
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	RERE MYBL2	8.04e-03	53	46	2	532
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHA2 PLEKHA7 RASAL1	1.54e-02	206	46	3	682
Coexpression	LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2	PRUNE2 RNF213 RERE SSH2 DNAH14	6.12e-05	176	62	5	M39223
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_DN	TNN IQSEC2 APLP1 DLEC1 MYBL2	1.09e-04	199	62	5	M5249
Coexpression	GSE23568_CTRL_VS_ID3_TRANSDUCED_CD8_TCELL_DN	BRCA1 NVL MTR BAG6 MYBL2	1.09e-04	199	62	5	M8507
Coexpression	GSE31082_DN_VS_CD8_SP_THYMOCYTE_DN	TRAF1 RNF213 RERE SSH2 SKIL	1.12e-04	200	62	5	M5063
Coexpression	GSE11961_FOLLICULAR_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN	BRCA1 RNF213 ZNFX1 HOOK2 DDX4	1.12e-04	200	62	5	M9341
Coexpression	GSE360_DC_VS_MAC_B_MALAYI_HIGH_DOSE_DN	IQSEC2 APLP1 DLEC1 NUP188 BAG6	1.12e-04	200	62	5	M5186
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_10H_DN	TRAF1 TRIM26 RNF213 ZNFX1 IFNA10	1.12e-04	200	62	5	M4269
Coexpression	GSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_DN	BRCA1 HJURP ZNFX1 RYR3 MYBL2	1.12e-04	200	62	5	M7162
Coexpression	GSE26351_UNSTIM_VS_WNT_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_UP	TRAF2 IQSEC2 TTC17 RERE CTTNBP2NL	1.12e-04	200	62	5	M8482
Coexpression	GSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4HIGH_BCELL_DN	TRAF1 TRIM26 PLEKHA2 ZNFX1 DDX4	1.12e-04	200	62	5	M9839
Coexpression	GSE17721_POLYIC_VS_PAM3CSK4_8H_BMDC_UP	PKD2L2 BRCA1 PLEKHA2 HOOK2 DDX4	1.12e-04	200	62	5	M3838
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ACAD11 RERE PPFIA3 CCDC144NL ALOX15	9.44e-07	125	63	5	9e98dcfdc768ae492f453efc08926164bbb0a909
ToppCell	droplet-Lung-LUNG-1m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 RADX DLEC1 DDX4 MYBL2	3.92e-06	167	63	5	e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 BRCA1 RADX DDX4 MYBL2	4.65e-06	173	63	5	15af4a0f7516dbf5c93ba66a19aca073ebe30d04
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	TRAF1 RADX RNF213 DDX3Y FUT8	5.80e-06	181	63	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MTR PLEKHA7 DNAH14 GOLGA4	7.92e-06	193	63	5	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDX3Y APLP1 RERE TRIP11 GOLGA4	8.33e-06	195	63	5	7796ea9247f4c63762f0de8490fed08b9717fa23
Disease	Mental Retardation, X-Linked	PCDH19 IQSEC2	1.70e-03	29	62	2	C1136249
Disease	allergic rhinitis	DLEC1 RERE ALOX15	2.79e-03	133	62	3	EFO_0005854
Disease	Cleft upper lip	MTR PLEKHA7	3.06e-03	39	62	2	C0008924
Disease	hepatocellular carcinoma	TRIM26 DLEC1	3.38e-03	41	62	2	EFO_0000182

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEERQRHAQDTAEGD	CTTNBP2NL	116	Q9P2B4
DNEREFISRELRGQH	ESYT3	91	A0FGR9
HGDREQREREQALGD	DDX4	571	Q9NQI0
NNHEGREEDQRLINL	BAG6	311	P46379
EEQQLRELQRHGYEN	APLP1	626	P51693
EGALDQLQHDVRLED	CCDC144NL	66	Q6NUI1
DNDNEENLIHGDFRL	ACAD11	211	Q709F0
HGENRQREIEIRFDQ	HJURP	426	Q8NCD3
DLDRAHEEFQQQERG	RASAL1	781	O95294
GQNLQLRHREEEDEF	RASSF2	36	P50749
EHLAKRARQGEEDNE	NVL	81	O15381
VEIQERNGKRHQDDE	RADX	591	Q6NSI4
LVDGRLDREQHDQYN	PCDH19	406	Q8TAB3
RHDFRIPQEEFDGNQ	IFNA10	56	P01566
NHEEEVNLLREQLGD	KRT40	226	Q6A162
RDQHFRGDNEEQEKL	NCBP2	21	P52298
EQEFREQIHNLEDRL	GOLGA4	2126	Q13439
HEQQAQRELGEVREK	KCNK4	31	Q9NYG8
ERNAGHAERTRQLED	HOOK2	336	Q96ED9
NKAEERHGNFEERLR	PPFIA3	386	O75145
QENRDLREESQLHRG	IQSEC2	56	Q5JU85
HEVQDARDQNELLEF	JAKMIP3	596	Q5VZ66
QGLFQKHREEELEER	ALOX15	121	P16050
DGDRDLQEHRQRIQA	EXOC8	36	Q8IYI6
EHDFEVRGDVVNGRN	BRCA1	1731	P38398
EKERANNFEHRIEDL	GCC2	1036	Q8IWJ2
FGGALNREDEHRENI	DNAH14	1776	Q0VDD8
GDRSQRDREEALHQF	DDX3Y	471	O15523
RGSENERHEEFVDQL	DLEC1	121	Q9Y238
EGNELQRHADEFLLD	FUT8	141	Q9BYC5
RQNRICGFLDIEEHE	PLEKHA2	6	Q9HB19
FEEQGEAERHVLRLQ	SZT2	3176	Q5T011
RDDERALAQEQGQHL	SFSWAP	46	Q12872
HDEEFVQRQDSPRDN	PRUNE2	566	Q8WUY3
DHAEADRQELQDELR	SKIL	641	P12757
RRANLLQEEEGSHED	SYNE3	791	Q6ZMZ3
HEEDEQLRALVRQFG	MYBL2	36	P10244
QERPHRFEDDGELNL	NFAM1	251	Q8NET5
IQREKLNEEHFRGQE	MTR	41	Q99707
HRGHDDIVNFERQEQ	PLEKHA7	326	Q6IQ23
GEDDQSQDVLRLHQD	RNF170	141	Q96K19
DNRDAQHVLERDLED	TEKT5	241	Q96M29
LVQDRHNENDSGREL	RERE	201	Q9P2R6
GNDFDNDHNRRIQVE	SSX1	81	Q16384
DNNRVREEHQGENLD	AMFR	386	Q9UKV5
DQNNREHVIDAFRPD	TRAF2	436	Q12933
RNDELNHLEEEGRFL	RNF213	4191	Q63HN8
HKEVQERFLADGNDR	UNC45B	791	Q8IWX7
LEFEERLRQEQEHHG	SSH2	871	Q76I76
RERLQGEHSQNGEEE	RILPL1	251	Q5EBL4
GEAREEQNIIFRHNI	TNN	76	Q9UQP3
HREQEELRRQQEGFK	PSPC1	366	Q8WXF1
DAFGELRDQQEQVRE	RYR3	4771	Q15413
AHEDDLQINDPEREF	NFATC3	126	Q12968
ALDDRRELHQFAQDG	NUP188	286	Q5SRE5
DQNNREHAIDAFRPD	TRAF1	351	Q13077
EFEQGHQFLREREEH	TRIM26	191	Q12899
AEQARREGFDENEIQ	PKD2L2	546	Q9NZM6
NEDRDTGLEQRHNKE	TTC17	96	Q96AE7
RRNQEGHASDEARDQ	ZNFX1	81	Q9P2E3
ENNHLQEELERLREE	TRIP11	861	Q15643
DEFVHRDNGERDNNE	WBP11	286	Q9Y2W2
DLQHLLGEQQERDRE	TCHH	1266	Q07283
ELRHQEQGRKFLEEE	TCHH	1366	Q07283