Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PTBI	IRS4 IRS2	4.44e-04	11	54	2	SM00310
Domain	IRS_PTB	IRS4 IRS2	5.32e-04	12	54	2	PS51064
Domain	IRS_PTB	IRS4 IRS2	7.30e-04	14	54	2	IPR002404
Domain	IRS	IRS4 IRS2	7.30e-04	14	54	2	PF02174
Pubmed	The IRS-signalling system: a network of docking proteins that mediate insulin action.	IRS4 IRS2	2.83e-06	2	59	2	9609109
Pubmed	Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.	IRS2 FOXA2	8.48e-06	3	59	2	12869553
Pubmed	Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.	IRS4 IRS2	8.48e-06	3	59	2	15155816
Pubmed	IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.	IRS4 IRS2	8.48e-06	3	59	2	10594015
Pubmed	Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.	IRS4 IRS2	8.48e-06	3	59	2	24567904
Pubmed	53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.	IRS4 IRS2	1.69e-05	4	59	2	17965023
Pubmed	The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function.	PHOX2B FOXA2	1.69e-05	4	59	2	23988578
Pubmed	Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.	SOX11 FOXA2 MARCKS	2.44e-05	33	59	3	33951080
Pubmed	16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells.	RASA1 KDR	2.82e-05	5	59	2	10319320
Pubmed	Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung.	KDR FOXA2	2.82e-05	5	59	2	16494859
Pubmed	Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.	IRS4 IRS2	2.82e-05	5	59	2	18202124
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	CLCN6 DAZAP2 E2F3	5.08e-05	42	59	3	7584044
Pubmed	fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.	KDR FOXA2	5.91e-05	7	59	2	8001822
Pubmed	The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.	IRS2 FOXA2	5.91e-05	7	59	2	12488434
Pubmed	Differential roles of insulin receptor substrates in brown adipocyte differentiation.	IRS4 IRS2	5.91e-05	7	59	2	14966273
Pubmed	Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.	E2F3 JMY	7.87e-05	8	59	2	15706352
Pubmed	The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives.	KDR FOXA2	7.87e-05	8	59	2	9486531
Pubmed	Striking parallels between carotid body glomus cell and adrenal chromaffin cell development.	SOX11 PHOX2B	7.87e-05	8	59	2	29807017
Pubmed	Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.	PHOX2B FOXA2	1.01e-04	9	59	2	11076756
Pubmed	Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.	KDR FOXA2	1.01e-04	9	59	2	10079226
Pubmed	KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.	KDR FOXA2	1.01e-04	9	59	2	23746980
Pubmed	IRS2 signalling is required for the development of a subset of sensory spinal neurons.	IRS4 IRS2	1.01e-04	9	59	2	22288475
Pubmed	Endothelial cells are not required for specification of respiratory progenitors.	KDR FOXA2	1.01e-04	9	59	2	28501476
Pubmed	Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.	PHOX2B FOXA2	1.01e-04	9	59	2	25840610
Pubmed	Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.	KDR FOXA2	1.01e-04	9	59	2	9876179
Pubmed	Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development.	SOX11 BCL11B	1.26e-04	10	59	2	39095712
Pubmed	Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.	IRS4 IRS2	1.26e-04	10	59	2	20416304
Pubmed	Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.	KDR FOXA2	1.26e-04	10	59	2	9811571
Pubmed	MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2.	KDR FOXA2	1.26e-04	10	59	2	27072135
Pubmed	TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo.	KDR FOXA2	1.26e-04	10	59	2	11458389
Pubmed	Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.	IRS4 IRS2	1.26e-04	10	59	2	21852217
Pubmed	Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences.	GPD1 MARCKS	1.26e-04	10	59	2	8406449
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX11 BCL11B ERF SKOR2 E2F3 PHOX2B FOXA2 TCFL5	1.43e-04	908	59	8	19274049
Pubmed	LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.	SOX11 BCL11B	1.54e-04	11	59	2	28053041
Pubmed	Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system.	SOX11 PHOX2B	1.54e-04	11	59	2	20147379
Pubmed	Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.	KDR FOXA2	1.54e-04	11	59	2	27297885
Pubmed	scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse.	SOX11 BCL11B	1.54e-04	11	59	2	34184026
Pubmed	SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.	IRS4 IRS2	1.54e-04	11	59	2	12052866
Pubmed	The eed mutation disrupts anterior mesoderm production in mice.	KDR FOXA2	1.54e-04	11	59	2	7768172
Pubmed	Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse.	KDR FOXA2	1.85e-04	12	59	2	10964471
Pubmed	Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues.	SOX11 BCL11B	1.85e-04	12	59	2	26687222
Pubmed	Insulin receptor substrate 4 associates with the protein IRAS.	IRS4 IRS2	1.85e-04	12	59	2	11912194
Pubmed	Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization.	SOX11 BCL11B	2.18e-04	13	59	2	33579706
Pubmed	Cis-regulatory control of corticospinal system development and evolution.	SOX11 BCL11B	2.18e-04	13	59	2	22678282
Pubmed	Tgfβ signaling regulates temporal neurogenesis and potency of neural stem cells in the CNS.	PHOX2B FOXA2	2.18e-04	13	59	2	25467979
Pubmed	A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.	KDR FOXA2	2.18e-04	13	59	2	8565836
Pubmed	Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.	KDR FOXA2	2.18e-04	13	59	2	22040871
Pubmed	Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction.	PHOX2B FOXA2	2.54e-04	14	59	2	25530182
Pubmed	The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.	KDR FOXA2	2.54e-04	14	59	2	9851841
Pubmed	The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.	KDR FOXA2	2.54e-04	14	59	2	10804184
Pubmed	Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve.	PHOX2B FOXA2	2.54e-04	14	59	2	12571110
Pubmed	Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice.	BCL11B KDR	2.54e-04	14	59	2	25975775
Pubmed	FOXG1 sequentially orchestrates subtype specification of postmitotic cortical projection neurons.	SOX11 BCL11B	2.54e-04	14	59	2	35613274
Pubmed	Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes.	SOX11 BCL11B	2.93e-04	15	59	2	26203155
Pubmed	Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain.	BCL11B KDR	2.93e-04	15	59	2	29901792
Pubmed	Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.	ELN SMAD7	2.93e-04	15	59	2	23011393
Pubmed	Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.	BCL11B SLC12A2	2.93e-04	15	59	2	35379995
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	IRS4 HNRNPD SBSN	2.99e-04	76	59	3	36560452
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	BCL11B SKOR2 E2F3 PHOX2B FOXA2 TCFL5	3.18e-04	544	59	6	28473536
Pubmed	Interaction network of human early embryonic transcription factors.	RLF TNRC18 BCL11B ERF NUP214	3.26e-04	351	59	5	38297188
Pubmed	Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.	PHOX2B FOXA2	3.34e-04	16	59	2	10217145
Pubmed	Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.	KDR FOXA2	3.34e-04	16	59	2	11437453
Pubmed	Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.	KDR FOXA2	3.34e-04	16	59	2	14736742
Pubmed	Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.	KDR IRS2	3.34e-04	16	59	2	11897712
Pubmed	Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library.	DAZAP2 MARCKS	3.79e-04	17	59	2	7808216
Pubmed	Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.	SOX11 SNCB MARCKS	3.87e-04	83	59	3	19799774
Pubmed	Genetic lineage tracing identifies endocardial origin of liver vasculature.	KDR FOXA2	4.25e-04	18	59	2	27019112
Pubmed	Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.	KDR FOXA2	4.25e-04	18	59	2	28854362
Pubmed	LncCMRR Plays an Important Role in Cardiac Differentiation by Regulating the Purb/Flk1 Axis.	KDR FOXA2	4.25e-04	18	59	2	36318802
Pubmed	p120-catenin regulates WNT signaling and EMT in the mouse embryo.	KDR FOXA2	4.75e-04	19	59	2	31371508
Pubmed	The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.	KDR FOXA2	4.75e-04	19	59	2	15817462
Pubmed	Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.	BCL11B KDR	4.75e-04	19	59	2	23395374
Pubmed	Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers.	KDR ELN	4.75e-04	19	59	2	29665133
Pubmed	Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.	BCL11B ZSWIM6	4.75e-04	19	59	2	28433741
Pubmed	Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.	SOX11 SKOR2	5.27e-04	20	59	2	31291246
Pubmed	Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.	BCL11B ZSWIM6	5.27e-04	20	59	2	22028030
Pubmed	HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.	KDR FOXA2	5.27e-04	20	59	2	10498685
Pubmed	Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.	PHOX2B FOXA2	5.82e-04	21	59	2	19542360
Pubmed	Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis.	PHOX2B FOXA2	5.82e-04	21	59	2	17922007
Pubmed	Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function.	KDR ELN	5.82e-04	21	59	2	33372189
Pubmed	The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.	SOX11 BCL11B	5.82e-04	21	59	2	27600842
Pubmed	Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.	KDR FOXA2	6.39e-04	22	59	2	9136933
Pubmed	Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.	KDR FOXA2	6.39e-04	22	59	2	16912273
Pubmed	Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.	KDR SMAD7	6.39e-04	22	59	2	34184034
Pubmed	Cited2 is required for fetal lung maturation.	KDR FOXA2	6.39e-04	22	59	2	18358466
Pubmed	Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.	KDR FOXA2	7.00e-04	23	59	2	20934536
Pubmed	Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.	KDR POLR2M	7.00e-04	23	59	2	22535667
Pubmed	DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex.	SOX11 BCL11B	7.00e-04	23	59	2	30329130
Pubmed	p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.	COL7A1 BCL11B	7.62e-04	24	59	2	28604778
Pubmed	Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.	KDR FOXA2	7.62e-04	24	59	2	21693517
Pubmed	MesP1 and MesP2 are essential for the development of cardiac mesoderm.	KDR FOXA2	7.62e-04	24	59	2	10887078
Pubmed	Multiple knockout mouse models reveal lincRNAs are required for life and brain development.	BCL11B TUG1	7.62e-04	24	59	2	24381249
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	SOX11 KDR PHOX2B FOXA2 SMAD7	7.67e-04	424	59	5	21731673
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TNRC18 IRS4 SLC12A2 KDR NUP214	8.17e-04	430	59	5	35044719
Pubmed	Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis.	KDR FOXA2	8.28e-04	25	59	2	15136151
Pubmed	Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development.	KDR FOXA2	8.28e-04	25	59	2	36046192
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	TNRC18 CBX6 NUP214	8.80e-04	110	59	3	26841866
Pubmed	Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.	KDR FOXA2	8.96e-04	26	59	2	28087629
Pubmed	Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.	PHOX2B FOXA2	8.96e-04	26	59	2	21752929
Pubmed	SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms.	SOX11 SLC12A2	9.66e-04	27	59	2	36343245
Interaction	XKR6 interactions	XKR6 RETSAT SLC27A3	7.06e-07	7	56	3	int:XKR6
Cytoband	22q12.2	TBC1D10A SLC35E4 TUG1	5.92e-05	58	59	3	22q12.2
Cytoband	Xq22.3	IRS4 TEX13A	8.36e-04	33	59	2	Xq22.3
Cytoband	18q21.1	SKOR2 SMAD7	1.11e-03	38	59	2	18q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	IRS4 ARMCX4 TEX13A	1.44e-03	172	59	3	chrXq22
Cytoband	Ensembl 112 genes in cytogenetic band chr22q12	TBC1D10A SLC35E4 TUG1	3.49e-03	235	59	3	chr22q12
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KDR ELN SNCB MARCKS SLC27A3	2.36e-06	161	59	5	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KDR ELN SNCB MARCKS SLC27A3	2.36e-06	161	59	5	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KDR ELN SNCB MARCKS SLC27A3	2.43e-06	162	59	5	2ac02523348660e514d464f8f2434ee0c312d784
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DPEP1 KDR ELN MARCKS SLC27A3	3.08e-06	170	59	5	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERF CBX6 IRS2 HNRNPD SMAD7	4.78e-06	186	59	5	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERF CBX6 IRS2 HNRNPD SMAD7	5.17e-06	189	59	5	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	PND03-Endothelial-Endothelial_blood-vessel\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KDR ARMCX4 RGS12 MARCKS SMAD7	5.87e-06	194	59	5	f93f5148b136819d87faef89707dbaba07d6c2b5
ToppCell	PND03-Endothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KDR ARMCX4 RGS12 MARCKS SMAD7	6.17e-06	196	59	5	a529681d822a95dd1980b7b1c71dc61aaf0baecd
ToppCell	Epithelial_cells-Basal_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	COL7A1 BCL11B ELN RGS12 MARCKS	6.48e-06	198	59	5	4235005c49fc2b29ad3a0ee6b608f0109d04f775
Disease	amnestic disorder (implicated_via_orthology)	IRS4 IRS2 HRH3	5.69e-07	9	57	3	DOID:10914 (implicated_via_orthology)
Disease	uremia (implicated_via_orthology)	ANKS6 HNRNPD	2.19e-05	4	57	2	DOID:4676 (implicated_via_orthology)
Disease	pterygium (is_marker_for)	KDR ELN	1.31e-04	9	57	2	DOID:0002116 (is_marker_for)
Disease	chenodeoxycholate measurement	KCNK10 SMAD7	3.79e-04	15	57	2	EFO_0010471
Disease	Lung diseases	ELN PHOX2B FOXA2	4.69e-04	78	57	3	C0024115
Disease	Kuhnt-Junius degeneration (is_implicated_in)	KDR ELN	4.89e-04	17	57	2	DOID:10873 (is_implicated_in)
Disease	Epilepsy, Benign Psychomotor, Childhood	SLC12A2 KDR	9.04e-04	23	57	2	C0393672
Disease	Epilepsy, Lateral Temporal	SLC12A2 KDR	9.04e-04	23	57	2	C0393682
Disease	Uncinate Epilepsy	SLC12A2 KDR	9.04e-04	23	57	2	C0014558
Disease	Epilepsy, Temporal Lobe	SLC12A2 KDR	9.04e-04	23	57	2	C0014556
Disease	serum albumin measurement	DPEP1 COL7A1 SLC12A2 TBC1D10A E2F3 RGS12	9.69e-04	592	57	6	EFO_0004535
Disease	lifestyle measurement	SOX11 MFSD2B XKR6 RGS12	1.11e-03	235	57	4	EFO_0010724
Disease	type 2 diabetes mellitus (implicated_via_orthology)	BCL11B IRS4 IRS2	1.11e-03	105	57	3	DOID:9352 (implicated_via_orthology)
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	PGS1 XKR6 JMY RGS12	1.26e-03	243	57	4	EFO_0004612, EFO_0020944
Disease	glucose metabolism disease (implicated_via_orthology)	IRS4 IRS2	1.34e-03	28	57	2	DOID:4194 (implicated_via_orthology)
Disease	colorectal cancer (is_implicated_in)	KDR PHOX2B SMAD7	1.67e-03	121	57	3	DOID:9256 (is_implicated_in)
Disease	melanoma (is_marker_for)	KDR ELN	1.86e-03	33	57	2	DOID:1909 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VAGADKSGGSAGGLA	ERF	396	P50548
FEKVAAGVAGAAGGG	CBX6	391	O95503
AGAGAEAGAGAEAGA	ARMCX4	1811	Q5H9R4
TAAGVAGAAAGVAGA	RASA1	91	P20936
AGAAAGVAGAAVAGP	RASA1	96	P20936
GKGAAAAAAASGAAG	INTS3	6	Q68E01
DAGARFGAGATAGNI	DAZAP2	111	Q15038
QAGARGGAEAGGAAS	JMY	61	Q8N9B5
AIAGAATIGAGGNKG	GARIN4	311	Q8IYT1
AVAKAAGEGGGAGEA	PNMA6E	116	A0A0J9YXQ4
AGAAGEAGAVGEAGA	PNMA6E	256	A0A0J9YXQ4
AVGEAGAAGEAGAVG	PNMA6E	276	A0A0J9YXQ4
NGFFGAKGVAGAIPA	PGS1	416	Q32NB8
VFGEGTAAASAGGFG	NUP214	2011	P35658
GGKVSGAAADPVAGF	MFSD2B	86	A6NFX1
FLSGFVAGAVVGAAG	EXOG	16	Q9Y2C4
TVGFGDFVAGGNAGI	KCNK10	276	P57789
EGDGGAAAGAAAAGA	IRS2	366	Q9Y4H2
AAAGVAAAFGAPIGG	CLCN6	246	P51797
VPGAGGGAAKALADE	BCL11B	576	Q9C0K0
AGGGEGAAVVAAAAA	E2F3	16	O00716
AAEFGGAAGNVEAPG	POLR2M	56	Q6EEV4
GDVPAKAEAGAEAGG	HSD17B1	286	P14061
DGGGGAAVAARSDKG	EEF1AKMT2	6	Q5JPI9
GAGLGFEQAAFDVGR	JMJD4	406	Q9H9V9
GAEVAGPGAAAAGAV	ANKS6	51	Q68DC2
GGKDEAAGGAAAAAA	MARCKS	191	P29966
VVAVGAGFCDGLGFG	GPD1	206	P21695
LAGEAAAAGGARGFS	HRH3	16	Q9Y5N1
SATAKGERGFPGADG	COL7A1	1291	Q02388
KEVAGARAVGFGGDF	DPEP1	291	P16444
AKAAQFGLVGAAGLG	ELN	696	P15502
GSEAGKFGQGVDNAA	SBSN	146	Q6UWP8
SVAAAAAVASGGGVG	LRRC4B	631	Q9NT99
AAAPGIGAAAAAAGF	IRS4	1141	O14654
AAGAAGSGKKAAAGA	FOXA2	266	Q9Y261
FGGDGAAAAATAAVG	HNRNPD	6	Q14103
GFGGLAAAAILAKAG	RETSAT	76	Q6NUM9
LGGAVFSGAGNIAAA	SNCB	66	Q16143
AGAKAGAGKAAQSGD	SOX11	176	P35716
AFASGLGGEGADVFV	TMCO4	86	Q5TGY1
AKAFGREGSGAQGEA	TNRC18	661	O15417
MAAKSDGGGVGVGFA	XKR6	1	Q5GH73
GAGAAGGAEADLKAL	SMAD7	81	O15105
GINGAAADLFLVGGD	RGS12	996	O14924
VAGAGAEAPAVAGAG	RLF	11	Q13129
GAGDAAAGSGAEFAG	SLC27A3	136	Q5K4L6
AAGSGAEFAGGDGAA	SLC27A3	141	Q5K4L6
AGFKVAGIAAALGGG	STX17	251	P56962
AAGAGAGAKQTPADG	SLC12A2	106	P55011
PGEAAAAAAAGFGAA	TUG1	91	A0A6I8PU40
AAAAAGFGAAGEAGV	TUG1	96	A0A6I8PU40
TTGVLAGFFGAGEAG	TIMM23B	11	Q5SRD1
AAAVAAAAAVAGGGG	SKOR2	261	Q2VWA4
DAGAAAEALGGAGAG	SKOR2	426	Q2VWA4
AAAAGAGAPSVGAAG	ZSWIM6	181	Q9HCJ5
GLKAGAIGCGGFAAF	TIMM22	171	Q9Y584
AAAAGGEDAAAAGGG	UBR3	66	Q6ZT12
AVAAAGAAGGKGAEE	TEX13A	181	Q9BXU3
AEVGAAAGGAQAAGP	SLC35E4	16	Q6ICL7
GRGAFGQVIEADAFG	KDR	841	P35968
DKFGFIVGSQGAEGA	TBC1D10A	56	Q9BXI6
PGKGGAAAAAAAAAA	PHOX2B	236	Q99453
GAAKEGAGAAAAAAG	TCFL5	156	Q9UL49
AGEAGPVSKAAAGGA	PRRT1B	81	A0A1B0GWB2