Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC16A13 SLC4A7 TIMM23B SLC22A15 TIMM23 ABCC5 KCNK16 CALHM6 SLC35E2B CYB561A3 ABCA7 SLC35E2A TRPM8 CACNA1G RFT1 ATP1B3 ABCC10	2.13e-04	1289	100	17	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC16A13 SLC4A7 TIMM23B SLC22A15 TIMM23 ABCC5 KCNK16 CALHM6 SLC35E2B CYB561A3 ABCA7 SLC35E2A TRPM8 CACNA1G ATP1B3 ABCC10	2.45e-04	1180	100	16	GO:0022857
GeneOntologyMolecularFunction	glycerophosphodiester phosphodiesterase activity	GDPD2 GDPD5	3.68e-04	6	100	2	GO:0008889
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	TIMM23B TIMM23 ABCC5	6.52e-04	34	100	3	GO:0022884
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC16A13 SLC4A7 ABCC5 SLC35E2B CYB561A3 ABCA7 SLC35E2A ATP1B3 ABCC10	6.54e-04	477	100	9	GO:0022804
GeneOntologyMolecularFunction	dolichyl-phosphate-mannose-protein mannosyltransferase activity	POMT2 POMT1	6.82e-04	8	100	2	GO:0004169
Domain	Arp1	ACTR1B ACTR1A	2.73e-05	2	98	2	IPR029909
Domain	PMT_4TMC	POMT2 POMT1	2.73e-05	2	98	2	PF16192
Domain	PMT_4TMC	POMT2 POMT1	2.73e-05	2	98	2	IPR032421
Domain	PMT	POMT2 POMT1	2.73e-05	2	98	2	PF02366
Domain	Glyco_trans_39/83	POMT2 POMT1	2.73e-05	2	98	2	IPR003342
Domain	GlyclTrfase_39-like	POMT2 POMT1	1.62e-04	4	98	2	IPR027005
Domain	MAPEG-like_dom	TMEM79 LTC4S	5.63e-04	7	98	2	IPR023352
Domain	GP_PDE_dom	GDPD2 GDPD5	5.63e-04	7	98	2	IPR030395
Domain	-	TMEM79 LTC4S	5.63e-04	7	98	2	1.20.120.550
Domain	GlyceroP-diester-Pdiesterase	GDPD2 GDPD5	5.63e-04	7	98	2	IPR004129
Domain	GP_PDE	GDPD2 GDPD5	5.63e-04	7	98	2	PS51704
Domain	GDPD	GDPD2 GDPD5	5.63e-04	7	98	2	PF03009
Domain	MIR	POMT2 POMT1	1.19e-03	10	98	2	PS50919
Domain	MIR	POMT2 POMT1	1.19e-03	10	98	2	PF02815
Domain	Sugar_P_trans_dom	SLC35E2B SLC35E2A	1.19e-03	10	98	2	IPR004853
Domain	MIR	POMT2 POMT1	1.19e-03	10	98	2	SM00472
Domain	MIR_motif	POMT2 POMT1	1.19e-03	10	98	2	IPR016093
Domain	TPT	SLC35E2B SLC35E2A	1.19e-03	10	98	2	PF03151
Domain	ABC_transporter_CS	ABCC5 ABCA7 ABCC10	1.39e-03	42	98	3	IPR017871
Domain	ABC_tran	ABCC5 ABCA7 ABCC10	2.04e-03	48	98	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCC5 ABCA7 ABCC10	2.04e-03	48	98	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCC5 ABCA7 ABCC10	2.17e-03	49	98	3	PS00211
Domain	ABC_transporter-like	ABCC5 ABCA7 ABCC10	2.30e-03	50	98	3	IPR003439
Domain	LY	LDLR ROS1	2.74e-03	15	98	2	SM00135
Domain	LDLR_classB_rpt	LDLR ROS1	2.74e-03	15	98	2	IPR000033
Domain	Actin_CS	ACTR1B ACTR1A	3.12e-03	16	98	2	IPR004001
Domain	ACTINS_2	ACTR1B ACTR1A	3.52e-03	17	98	2	PS00432
Domain	Actin/actin-like_CS	ACTR1B ACTR1A	3.95e-03	18	98	2	IPR020902
Domain	ACTINS_ACT_LIKE	ACTR1B ACTR1A	4.40e-03	19	98	2	PS01132
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	SLC4A7 HM13 LDLR C2CD2 IGF2R LNPK PBXIP1	8.69e-07	176	101	7	28692057
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	POMT2 TMEM67 LAMC3 POMT1 HM13 ABCA7 LDLR DMXL1 IGF2R RNFT1 TMED9 RFT1 ATP1B3 PBXIP1 ADGRA3	2.01e-06	1201	101	15	35696571
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	TIMM23B HM13 ACTR1A ESYT2 FASN IGF2R CLNS1A TMED9 ATP1B3	3.11e-06	408	101	9	33766124
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	SLC4A7 TMEM237 AHCTF1 HM13 C2CD2 ESYT2 FASN LNPK RFT1 PBXIP1	6.34e-06	568	101	10	37774976
Pubmed	Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2.	POMT2 POMT1	8.35e-06	2	101	2	19880378
Pubmed	SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.	SLC35E2B SLC35E2A	8.35e-06	2	101	2	35247439
Pubmed	Physical and functional association of human protein O-mannosyltransferases 1 and 2.	POMT2 POMT1	8.35e-06	2	101	2	16698797
Pubmed	POMT1 and POMT2 mutations in CMD patients: a multicentric Italian study.	POMT2 POMT1	8.35e-06	2	101	2	18513969
Pubmed	POMT1 and POMT2 gene mutations result in 2 cases of alpha-dystroglycanopathy.	POMT2 POMT1	8.35e-06	2	101	2	34565739
Pubmed	Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland.	TIMM23B TIMM23	8.35e-06	2	101	2	11165051
Pubmed	Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.	ACTR1B ACTR1A	8.35e-06	2	101	2	7696711
Pubmed	Walker-Warburg syndrome.	POMT2 POMT1	8.35e-06	2	101	2	16887026
Pubmed	Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.	POMT2 POMT1	8.35e-06	2	101	2	28512129
Pubmed	Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.	POMT2 POMT1	8.35e-06	2	101	2	14699049
Pubmed	Effect of Tim23 knockdown in vivo on mitochondrial protein import and retrograde signaling to the UPRmt in muscle.	TIMM23B TIMM23	8.35e-06	2	101	2	29949403
Pubmed	Different roles of the two components of human protein O-mannosyltransferase, POMT1 and POMT2.	POMT2 POMT1	8.35e-06	2	101	2	21782786
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	SLC4A7 TMEM237 MARK1 ABCC5 HM13 ESYT2 IGF2R LNPK RFT1	9.21e-06	467	101	9	30194290
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SLC4A7 TMEM237 AHCTF1 HM13 LDLR ESYT2 FASN IGF2R TMED9 ZMYM1 LNPK CDC20 ATP1B3 PBXIP1	1.01e-05	1203	101	14	29180619
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TMPPE VPS18 TMEM237 POMT1 LDLR C2CD2 BLVRA IGF2R TMED9 RFT1 FITM2 ABCC10 ADGRA3	1.26e-05	1061	101	13	33845483
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TIMM23B LAMC3 SLC35E2B ABCA7 LDLR C2CD2 ACOX3 ACTR1A GDPD5 FASN IGF2R PCNX1 ABCC10	1.93e-05	1105	101	13	35748872
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	TIMM23B HM13 ACTR1A ESYT2 FASN IGF2R CLNS1A TMED9 PCNX1 ATP1B3	2.22e-05	657	101	10	36180527
Pubmed	Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6.	GDPD2 GDPD5	2.50e-05	3	101	2	15276213
Pubmed	Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes.	TIMM23B TIMM23	2.50e-05	3	101	2	12437925
Pubmed	Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction.	FLT4 LDLR	2.50e-05	3	101	2	30420641
Pubmed	Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions.	CLEC6A LDLR	2.50e-05	3	101	2	31868000
Pubmed	Mutant huntingtin does not cross the mitochondrial outer membrane.	TIMM23B TIMM23	2.50e-05	3	101	2	32821928
Pubmed	Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice.	TIMM23B TIMM23	2.50e-05	3	101	2	31326434
Pubmed	POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo.	POMT2 POMT1	2.50e-05	3	101	2	18490429
Pubmed	Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease.	TIMM23B TIMM23	2.50e-05	3	101	2	30405116
Pubmed	Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.	ABCA7 LDLR	2.50e-05	3	101	2	22403608
Pubmed	Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.	FLT4 LDLR	2.50e-05	3	101	2	24723556
Pubmed	POMGnT1, POMT1, and POMT2 mutations in congenital muscular dystrophies.	POMT2 POMT1	2.50e-05	3	101	2	20816175
Pubmed	The emerging physiological roles of the glycerophosphodiesterase family.	GDPD2 GDPD5	2.50e-05	3	101	2	24373430
Pubmed	Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion.	POMT2 POMT1	2.50e-05	3	101	2	24297939
Pubmed	Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF‑κB signaling.	LDLR ROS1	2.50e-05	3	101	2	33760160
Pubmed	Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice.	CLEC6A LDLR	2.50e-05	3	101	2	30867470
Pubmed	NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.	TIMM23B TIMM23	2.50e-05	3	101	2	37044213
Pubmed	Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements.	USP6 ROS1	2.50e-05	3	101	2	29617048
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCC5 ABCA7 ABCC10	4.04e-05	23	101	3	10708515
Pubmed	Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.	TIMM23B TIMM23	4.99e-05	4	101	2	19111522
Pubmed	The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix.	TIMM23B TIMM23	4.99e-05	4	101	2	10393182
Pubmed	Tight junction-based epithelial microenvironment and cell proliferation.	CLDN15 CLDN24	4.99e-05	4	101	2	19029935
Pubmed	Expression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndrome.	POMT2 POMT1	4.99e-05	4	101	2	17456771
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	LDLR IGF2R TMED9 ATP1B3	5.61e-05	71	101	4	12754519
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	POMT2 SLC4A7 LAMC3 POMT1 FAN1 MICU1 ACTR1A USP6 TAS2R14 ZMYM1 ABCC10	7.99e-05	925	101	11	28986522
Pubmed	Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.	CLEC6A LTC4S	8.30e-05	5	101	2	19124755
Pubmed	Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality.	POMT2 POMT1	8.30e-05	5	101	2	15383666
Pubmed	Refining genotype phenotype correlations in muscular dystrophies with defective glycosylation of dystroglycan.	POMT2 POMT1	8.30e-05	5	101	2	17878207
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	SLC4A7 TMEM237 TIMM23B TIMM23 ABCC5 HM13 ESYT2 IGF2R RFT1 ATP1B3 FITM2	1.03e-04	952	101	11	38569033
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	HM13 ESYT2 IGF2R RNFT1 LNPK RFT1 FITM2 PBXIP1	1.07e-04	499	101	8	22810586
Pubmed	Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice.	TIMM23B TIMM23	1.24e-04	6	101	2	15282315
Pubmed	Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals.	LDLR ROS1	1.24e-04	6	101	2	18097620
Pubmed	A spastic paraplegia mouse model reveals REEP1-dependent ER shaping.	TIMM23B TIMM23	1.24e-04	6	101	2	24051375
Pubmed	Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study.	POMT2 POMT1	1.24e-04	6	101	2	19299310
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	VPS18 MARK1 AHCTF1 ACTR1A STARD9 CLNS1A ADAMTS20 IGSF1	1.29e-04	513	101	8	25798074
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	HM13 ESYT2 FASN IGF2R CLNS1A TMED9 LNPK ATP1B3	1.34e-04	516	101	8	36610398
Pubmed	Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.	G6PC3 LNPK RFT1	1.58e-04	36	101	3	38070861
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	SLC4A7 MARK1 AHCTF1 HM13 IGF2R G6PC3 TMED9 LNPK CDC20 ATP1B3 PBXIP1	1.68e-04	1007	101	11	34597346
Pubmed	Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology.	TIMM23B TIMM23	1.74e-04	7	101	2	21984432
Pubmed	TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.	TMEM67 TMEM237	1.74e-04	7	101	2	26595381
Pubmed	Role of Bax and Bak in mitochondrial morphogenesis.	TIMM23B TIMM23	1.74e-04	7	101	2	17035996
Pubmed	Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.	ACTR1B ACTR1A	1.74e-04	7	101	2	12857853
Pubmed	Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.	TIMM23B TIMM23	2.31e-04	8	101	2	15044455
Pubmed	Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.	ABCC5 ABCC10	2.31e-04	8	101	2	15802388
Pubmed	The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice.	TIMM23B TIMM23	2.97e-04	9	101	2	19752021
Pubmed	Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice.	FLT4 LDLR	2.97e-04	9	101	2	36051444
Pubmed	Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice.	FASN IGF2R NANOS3	3.51e-04	47	101	3	32892421
Pubmed	Mitocytosis, a migrasome-mediated mitochondrial quality-control process.	TIMM23B TIMM23	3.70e-04	10	101	2	34048705
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SLC4A7 TMEM237 AHCTF1 HM13 DMXL1 MICU1 ESYT2 IGF2R CLNS1A MRPS9 LNPK ATP1B3 PBXIP1	3.74e-04	1487	101	13	33957083
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	AHCTF1 TIMM23 HM13 ESYT2 FASN IGF2R TMED9 LNPK RFT1 ATP1B3	4.22e-04	942	101	10	31073040
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SLC4A7 HM13 ESYT2 IGF2R LNPK RFT1 PBXIP1	4.43e-04	468	101	7	31056421
Pubmed	AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.	POMT2 POMT1	5.41e-04	12	101	2	24256719
Pubmed	Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.	TIMM23B TIMM23	6.38e-04	13	101	2	10920231
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	VPS18 SLC4A7 DMXL1 ESYT2 IGF2R LNPK DOP1B	6.86e-04	504	101	7	34432599
Pubmed	Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.	LDLR FASN	7.43e-04	14	101	2	22055502
Pubmed	Genetic and structural characterization of the human mitochondrial inner membrane translocase.	TIMM23B TIMM23	7.43e-04	14	101	2	10339406
Pubmed	Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.	KCNK16 FITM2	7.43e-04	14	101	2	22158537
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	SLC4A7 ESYT2 IGF2R LNPK RFT1 PBXIP1	8.09e-04	375	101	6	32788342
Pubmed	Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.	PRLHR GALR2	8.55e-04	15	101	2	26053317
Pubmed	LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line.	ABCC5 ABCC10	8.55e-04	15	101	2	28112518
Pubmed	Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.	TIMM23B TIMM23	1.10e-03	17	101	2	11709546
Pubmed	Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	POMT2 POMT1	1.10e-03	17	101	2	20301468
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	ABCC5 POMT1 HM13 C2CD2 IGF2R ATP1B3 FITM2 RNF182	1.20e-03	719	101	8	35337019
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	ACTR1A CACNA1G	1.24e-03	18	101	2	31910261
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	LDLR FASN	1.38e-03	19	101	2	26685326
Pubmed	Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.	LDLR FASN	1.38e-03	19	101	2	37541847
Pubmed	HIV-host interactome revealed directly from infected cells.	HM13 FASN IGF2R PBXIP1	1.62e-03	172	101	4	27375898
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	VPS18 SLC4A7 TIMM23 LDLR MICU1 FASN TMEM242 VSIG10L MRPS9 TMED9 FITM2	1.65e-03	1327	101	11	32694731
Pubmed	Multifunctional strands in tight junctions.	CLDN15 CLDN24	1.69e-03	21	101	2	11283726
Pubmed	Claudin-based barrier in simple and stratified cellular sheets.	CLDN15 CLDN24	1.69e-03	21	101	2	12231346
Pubmed	Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	POMT2 POMT1	1.69e-03	21	101	2	20301582
Pubmed	Tight junction proteins.	CLDN15 CLDN24	1.69e-03	21	101	2	12475568
Pubmed	Tight junctions of the blood-brain barrier.	CLDN15 CLDN24	1.69e-03	21	101	2	10690502
Pubmed	The roles of claudin superfamily proteins in paracellular transport.	CLDN15 CLDN24	1.69e-03	21	101	2	11247307
Pubmed	Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.	TIMM23B TIMM23	1.86e-03	22	101	2	11431695
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC5 ABCC10	1.86e-03	22	101	2	8894702
Pubmed	Structure and function of claudins.	CLDN15 CLDN24	2.03e-03	23	101	2	18036336
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	LDLR FASN	2.03e-03	23	101	2	26508642
Pubmed	The claudins.	CLDN15 CLDN24	2.03e-03	23	101	2	19706201
Pubmed	The DNA sequence and analysis of human chromosome 6.	KCNK16 CALHM6 MEI4 IGF2R ROS1 ABCC10 OR2H2	2.29e-03	622	101	7	14574404
GeneFamily	Dolichyl D-mannosyl phosphate dependent mannosyltransferases\|Phosphatidylinositol glycan anchor biosynthesis	POMT2 POMT1	3.97e-04	9	61	2	430
GeneFamily	ATP binding cassette subfamily C	ABCC5 ABCC10	8.53e-04	13	61	2	807
GeneFamily	Claudins	CLDN15 CLDN24	2.71e-03	23	61	2	488
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	POMT2 TMPPE SLC16A13 SLC4A7 ABCC5 SLC35E2B LDLR ESYT2 G6PC3 SLC35E2A TMED9 CDC20 FITM2 ADGRA3	5.23e-07	703	101	14	MM1055
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	POMT2 TMPPE SLC16A13 SLC4A7 ABCC5 SLC35E2B LDLR ESYT2 G6PC3 TMED9 CDC20 FITM2 ADGRA3	2.20e-06	681	101	13	M5314
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	POMT2 CLDN15 TAS2R14 VSIG10L CACNA1G ADGRA3	9.55e-07	144	101	6	5e948d4cb913ccd8f82262a1b4d20967aadab3ab
Drug	4-hydroxyderricin	LDLR ACOX3 FASN	2.76e-06	7	99	3	CID006438503
Disease	Cobblestone Lissencephaly	POMT2 POMT1	3.01e-05	3	94	2	C0431376
Disease	Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1	POMT2 POMT1	9.98e-05	5	94	2	cv:C4284790
Disease	lissencephaly (is_implicated_in)	POMT2 POMT1	9.98e-05	5	94	2	DOID:0050453 (is_implicated_in)
Disease	Walker-Warburg syndrome (is_implicated_in)	POMT2 POMT1	9.98e-05	5	94	2	DOID:0050560 (is_implicated_in)
Disease	MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 1	POMT2 POMT1	9.98e-05	5	94	2	236670
Disease	Qualitative or quantitative defects of alpha-dystroglycan	POMT2 POMT1	1.49e-04	6	94	2	cv:C2936406
Disease	Walker-Warburg syndrome (implicated_via_orthology)	POMT2 POMT1	2.09e-04	7	94	2	DOID:0050560 (implicated_via_orthology)
Disease	hemoglobin measurement, mean corpuscular hemoglobin concentration	TMPRSS6 TMEM79	2.78e-04	8	94	2	EFO_0004509, EFO_0004528
Disease	Congenital muscular dystrophy	POMT2 POMT1	6.49e-04	12	94	2	cv:C0699743
Disease	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K	POMT2 POMT1	8.91e-04	14	94	2	C1836373
Disease	nephroblastoma (is_implicated_in)	IGF2R BRCA2	8.91e-04	14	94	2	DOID:2154 (is_implicated_in)
Disease	alpha-Dystroglycanopathies	POMT2 POMT1	8.91e-04	14	94	2	C2936406
Disease	Muscle eye brain disease	POMT2 POMT1	8.91e-04	14	94	2	C0457133
Disease	Fukuyama Type Congenital Muscular Dystrophy	POMT2 POMT1	8.91e-04	14	94	2	C0410174
Disease	Muscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1	POMT2 POMT1	8.91e-04	14	94	2	C4284790
Disease	Walker-Warburg congenital muscular dystrophy	POMT2 POMT1	1.03e-03	15	94	2	C0265221
Disease	melanoma	FASN BRCA2 CLNS1A ADAMTS20 ROS1	1.20e-03	248	94	5	C0025202
Disease	muscular dystrophy (is_implicated_in)	POMT2 POMT1	1.32e-03	17	94	2	DOID:9884 (is_implicated_in)
Disease	Malignant Glioma	DMXL1 BRCA2 ROS1	1.47e-03	70	94	3	C0555198
Disease	mixed gliomas	DMXL1 BRCA2 ROS1	1.47e-03	70	94	3	C0259783
Disease	Familial aplasia of the vermis	TMEM67 TMEM237	1.84e-03	20	94	2	cv:C0431399
Disease	Joubert syndrome 1	TMEM67 TMEM237	2.03e-03	21	94	2	C4551568
Disease	hemoglobin measurement, mean corpuscular hemoglobin	TMPRSS6 TIMM23	2.23e-03	22	94	2	EFO_0004509, EFO_0004527
Disease	Glioma	DMXL1 BRCA2 ROS1	2.73e-03	87	94	3	C0017638
Disease	platelet component distribution width	VPS18 FLT4 SLC4A7 TMPRSS6 ABCC5 RPP14 CLNS1A NANOS3	2.85e-03	755	94	8	EFO_0007984
Disease	HMG CoA reductase inhibitor use measurement	LDLR BRCA2 NANOS3 PCNX1	3.17e-03	189	94	4	EFO_0009932

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLGLSFSWVLLALAL	ESYT2	131	A0FGR8
VYLWSASSGDILQLL	CDC20	206	Q12834
LSLLGWILSIITTYL	CLDN24	16	A6NM45
AVLGRLSALYALWSL	ACOX3	586	O15254
ALWSLSRHAALLYRG	ACOX3	596	O15254
LLALAVVSVGLWTLY	B4GALNT3	26	Q6L9W6
LLGASLTLLLYVALW	ADGRA3	996	Q8IWK6
RLYSTWIGGSILASL	ACTR1B	336	P42025
LLGDRWILTAAHTLY	C1R	491	P00736
TGSRLLTGSSYLQLW	DMXL1	121	Q9Y485
LKSWLIISLGLYSQV	FLRT2	16	O43155
WLTGLLYHLSLFITR	ADAMTS20	6	P59510
LSRSLPLFLTLAWIY	ABCA7	546	Q8IZY2
LWTDYLGLAHLVRAL	NANOS3	6	P60323
LSSSFLVLSYLLTRW	RFT1	411	Q96AA3
SRLRLLGNYSLWLEG	LY6G6F	81	Q5SQ64
WRTSTDYLLTRLLGE	MAB21L4	246	Q08AI8
LSRFSYAWLAPLLAR	ABCC10	221	Q5T3U5
LILVSYGAITWAVLR	OR2H2	211	O95918
SLLILSWIAISRYAT	GPR82	106	Q96P67
LLSRSYLAVWALSSL	LPAR2	181	Q9HBW0
YLAVWALSSLLVFLL	LPAR2	186	Q9HBW0
STYLWTGLLAISLFL	GPR155	456	Q7Z3F1
VYRSLAAIWILLGLA	KCNK16	231	Q96T55
SLNRRLYAWLLGSDI	DOP1B	291	Q9Y3R5
SLIYWTLFTLGLDLS	G6PC3	211	Q9BUM1
SLSALAELAVGSRWY	MICU1	6	Q9BPX6
LIWLLDYGSRNLTAT	PCNX1	1081	Q96RV3
APLYASARALWLLVA	LTC4S	106	Q16873
LATSSLAVYSILWSG	MT-ND1	106	P03886
LTFLLSLSWLYIGLV	GDPD2	46	Q9HCC8
LLLTFTFGLTLTWLY	GDPD5	46	Q8WTR4
LGLSSIVGVWYLLRK	HM13	166	Q8TCT9
VTLLWFLLLLGSYTV	OR4D6	206	Q8NGJ1
LGLAAYLWELTRSKT	PAGE3	66	Q5JUK9
ALAIYALLSLWYLLR	POMT1	606	Q9Y6A1
LALTWALNYRTGVRL	ABCC5	236	O15440
LVLGLTYARTLRYLW	GALR2	201	O43603
ASYRGSLLSDVLKIW	IGSF1	301	Q8N6C5
LYLLSLLWATAGTST	CBLIF	6	P27352
YADLGTLSRLWLAAL	HEATR5A	1441	Q86XA9
TLYIAESRLSWLDGS	CLNS1A	36	P54105
LATVGLYLAQWALAR	C2CD2	26	Q9Y426
ILSIWRPSSDLYSLL	BRCA2	2986	P51587
YLRSSWNVLDGLLVL	CACNA1G	1341	O43497
LALFLLGYVLSARTW	CALHM6	61	Q5R3K3
LGYVLSARTWRLLTG	CALHM6	66	Q5R3K3
LRRLSTLLVGTAIWY	FITM2	91	Q8N6M3
RLLLGALLVWTAAYV	CCDC188	346	H7C350
RLYSTWIGGSILASL	ACTR1A	336	P61163
ALYLGWSASLISILG	CLDN15	161	P56746
SRLTWLVSLFGELSL	BLVRA	171	P53004
WSLGVILYTLVSGSL	MARK1	241	Q9P0L2
GLLVLYILLASSWKR	CYB561A3	211	Q8NBI2
SSLGLLTGYIRRWIT	AHCTF1	556	Q8WYP5
YLSIVWKTLARALGL	FASN	891	P49327
LLGYFIRSWRTLAIL	SLC22A15	216	Q8IZD6
LWGQSLYILSSLLAE	PHKA2	401	P46019
LRYAVSAALWLAIGI	TMEM67	731	Q5HYA8
LTRLYLDKATLIWNG	NXT2	36	Q9NPJ8
STFSTLYGLLLWDII	FAN1	836	Q9Y2M0
WYLRTSKLALALAII	MEI4	6	A8MW99
KTYDLRLLSSLTGSW	IGF2R	2001	P11717
LAISRISLVWLIFGS	TAS2R14	51	Q9NYV8
QLSYLSLRTSIGLWT	SLC4A7	686	Q9Y6M7
ISLRLSAYAVLAIWA	PRLHR	171	P49683
LWYLFGDLSLSLVTV	POMT2	261	Q9UKY4
VTWYLLAGLRYLDLS	TLR10	111	Q9BXR5
GTYWALLRTLLTLAA	TMEM176A	111	Q96HP8
LILVLYLSTEIWGSS	SMIM23	41	A6NLE4
SDLGVWSSRALLYLT	SLC35E2A	66	P0CK97
SIRVLVWLLGLLYFS	RNF182	181	Q8N6D2
YRDSVLTWLLKDSLG	STARD9	336	Q9P2P6
RTAKSWGLILLFYLV	ATP1B3	31	P54709
LSLRLWSVAGISIAL	CLEC6A	16	Q6EIG7
ALLVGLSWLFLSYRP	TMEM237	366	Q96Q45
LLVLWLATRGSALYF	TMED9	26	Q9BVK6
TLWALSLLLGVARSL	PEX11G	131	Q96HA9
AWLLVFLAGSSVLLY	RNFT1	206	Q5M7Z0
TTGVLLLLAYREWTQ	TMEM212	56	A6NML5
YAWRGSLLLVSALSL	SLC16A13	166	Q7RTY0
ASLLRTYLARLPWAG	PBXIP1	616	Q96AQ6
AVSYRLLLWGRGSLA	MRPS9	11	P82933
TLLYAIEGGTWRLLR	KBTBD13	411	C9JR72
LTTWLTELYLSRLGA	VPS18	491	Q9P253
TYTLALWNSAAGLRR	FLT4	396	P35916
LTGLFAVSRLIYWLT	TMEM79	316	Q9BSE2
SSWLSLELFSFLRYL	KRT10-AS1	66	Q8N816
HLWTRLLSALAGLLY	TMEM44	261	Q2T9K0
SGLISSISIDWLYQR	ROS1	366	P08922
SDLGVWSSRALLYLT	SLC35E2B	66	P0CK96
LWANTLGSLALLYSA	TIMM23B	126	Q5SRD1
TNSSWLLRLAYLADI	ZBED5	466	Q49AG3
LSKLLYIALSWPITS	ZMYM1	1066	Q5SVZ6
LGRTSTYRDWVSLLI	VSIG10L	711	Q86VR7
SRLIYIAQSKGAWIL	TRPM8	166	Q7Z2W7
GLVKLWSSLTLLGSY	RPP14	81	O95059
SSLALRALGWGSLYA	TMEM242	76	Q9NWH2
LWANTLGSLALLYSA	TIMM23	126	O14925
ISLGLTLRLWDVYLV	USP6	276	P35125
ALLVLASAGVLLWYF	TMPRSS6	61	Q8IU80
FVNSLLLIGSLYIWR	TMPPE	51	Q6ZT21
LLIGSLYIWRSTVSN	TMPPE	56	Q6ZT21
ITLDLLSGRLYWVDS	LDLR	566	P01130
TSYALLWNLLEGRVA	LAMC3	1186	Q9Y6N6
LWVGRLILYSSVLYL	LNPK	41	Q9C0E8