Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsphingolipid delta-4 desaturase activity

DEGS1 DEGS2

3.12e-0521122GO:0042284
GeneOntologyBiologicalProcessmembrane lipid metabolic process

ATG7 SFTPB HACD4 DPM1 DEGS1 DEGS2 ALDH3B1 ALDH3B2 LARGE1

3.57e-062291099GO:0006643
GeneOntologyBiologicalProcesssphingolipid metabolic process

ATG7 SFTPB HACD4 DEGS1 DEGS2 ALDH3B1 ALDH3B2 LARGE1

4.37e-061761098GO:0006665
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by hormone

AVPR1B ECE1 ACE2 AGTR2 SERPINF2

7.27e-06511095GO:0001990
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure mediated by a chemical signal

AVPR1B ECE1 ACE2 AGTR2 SERPINF2

1.77e-05611095GO:0003044
GeneOntologyBiologicalProcessresponse to platelet-derived growth factor

PDGFRB MARS1 ENPP1 HAS1

2.08e-05311094GO:0036119
GeneOntologyBiologicalProcessregulation of blood pressure

ERAP1 AVPR1B ECE1 ACE2 KL GNA13 AGTR2 SERPINF2

3.78e-052371098GO:0008217
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure

AVPR1B ECE1 ACE2 KL AGTR2 SERPINF2

5.11e-051241096GO:0003073
GeneOntologyBiologicalProcessmetanephric glomerulus development

PDGFRB LAMB2 AGTR2

6.24e-05151093GO:0072224
GeneOntologyBiologicalProcessaminoglycan biosynthetic process

PDGFRB PTGER4 B3GNT8 NDST3 HAS1

6.59e-05801095GO:0006023
GeneOntologyBiologicalProcessorganic hydroxy compound metabolic process

AVPR1B ENPP1 SRD5A1 DPM1 TG HSD3B7 KL AGTR2 DEGS2 ALDH3B1 ALDH3B2 MVD

1.47e-0464110912GO:1901615
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

ATG7 HACD4 DPM1 DEGS1 DEGS2 LARGE1

1.88e-041571096GO:0046467
MousePhenoabnormal resting posture

ENPP1 CNTNAP1 GRID2 DYNC1H1

1.15e-078914MP:0009393
MousePhenoabnormal central memory CD4-positive, alpha-beta T cell number

KLHL6 DOCK8 TG LMBR1L PI4KA

1.31e-0630915MP:0012771
MousePhenoabnormal central memory CD4-positive, alpha-beta T cell morphology

KLHL6 DOCK8 TG LMBR1L PI4KA

1.31e-0630915MP:0010840
MousePhenoincreased central memory CD4-positive, alpha-beta T cell number

DOCK8 TG LMBR1L PI4KA

1.62e-0524914MP:0010841
MousePhenoabnormal CD4-positive, alpha-beta memory T cell morphology

KLHL6 DOCK8 TG LMBR1L PI4KA

2.82e-0555915MP:0010834
MousePhenoabnormal CD4-positive, alpha-beta memory T cell number

KLHL6 DOCK8 TG LMBR1L PI4KA

1.18e-0474915MP:0012769
DomainPeptidase_S54_rhomboid

RHBDD1 RHBDF1 RHBDF2

1.12e-0581113IPR002610
DomainPeptidase_S54_rhomboid_dom

RHBDD1 RHBDF1 RHBDF2

1.67e-0591113IPR022764
DomainRhomboid

RHBDD1 RHBDF1 RHBDF2

1.67e-0591113PF01694
Domain-

RHBDD1 RHBDF1 RHBDF2

1.67e-05911131.20.1540.10
DomainLipid_DES

DEGS1 DEGS2

3.50e-0521112PF08557
DomainSphingolipid_d4-desaturase_N

DEGS1 DEGS2

3.50e-0521112IPR013866
DomainRhomboid_SP

RHBDF1 RHBDF2

3.50e-0521112PF12595
DomainLipid_DES

DEGS1 DEGS2

3.50e-0521112SM01269
DomainDES1/DES2

DEGS1 DEGS2

3.50e-0521112IPR011388
DomainRhomboid_SP

RHBDF1 RHBDF2

3.50e-0521112IPR022241
DomainNAP_family

TSPY26P TSPYL1 TSPYL5

1.31e-04171113IPR002164
DomainNAP

TSPY26P TSPYL1 TSPYL5

1.31e-04171113PF00956
DomainAldehyde_DH_NAD(P)

ALDH3B1 ALDH3B2

2.08e-0441112IPR012394
DomainFA_desaturase_dom

DEGS1 DEGS2

9.57e-0481112IPR005804
DomainFA_desaturase

DEGS1 DEGS2

9.57e-0481112PF00487
Domain-

GLB1L3 HPSE2 KL

1.16e-033511133.20.20.80
DomainPI3Ka

PIK3CA PI4KA

1.23e-0391112PF00613
DomainPI3Ka

PIK3CA PI4KA

1.23e-0391112SM00145
Domain-

PIK3CA PI4KA

1.23e-03911121.25.40.70
DomainGlyco_hydro_catalytic_dom

GLB1L3 HPSE2 KL

1.48e-03381113IPR013781
DomainPI_Kinase

PIK3CA PI4KA

1.53e-03101112IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3CA PI4KA

1.53e-03101112IPR001263
DomainPIK_HELICAL

PIK3CA PI4KA

1.53e-03101112PS51545
DomainCRAL-bd_toc_tran

SEC14L6 SEC14L5

2.22e-03121112IPR001071
DomainCRAL_TRIO_N

SEC14L6 SEC14L5

2.22e-03121112SM01100
DomainCRAL/TRIO_N_dom

SEC14L6 SEC14L5

3.49e-03151112IPR011074
DomainPI3/4_kinase_CS

PIK3CA PI4KA

3.49e-03151112IPR018936
DomainIBN_N

XPO1 RANBP17

3.49e-03151112PF03810
DomainGlycoside_hydrolase_SF

GLB1L3 HPSE2 KL

3.86e-03531113IPR017853
Domain-

PIK3CA PI4KA

3.98e-031611121.10.1070.11
DomainIBN_N

XPO1 RANBP17

3.98e-03161112SM00913
DomainPI3Kc

PIK3CA PI4KA

3.98e-03161112SM00146
DomainAld_DH_CS_GLU

ALDH3B1 ALDH3B2

3.98e-03161112IPR029510
DomainARM-type_fold

USP34 DOCK8 INTS1 XPO1 RANBP17 PIK3CA PI4KA

4.14e-033391117IPR016024
DomainImportin-beta_N

XPO1 RANBP17

4.49e-03171112IPR001494
DomainAld_DH_CS_CYS

ALDH3B1 ALDH3B2

4.49e-03171112IPR016160
DomainPI3_PI4_kinase

PIK3CA PI4KA

5.03e-03181112PF00454
DomainPI3_4_KINASE_1

PIK3CA PI4KA

5.03e-03181112PS00915
DomainPI3_4_KINASE_2

PIK3CA PI4KA

5.03e-03181112PS00916
DomainALDEHYDE_DEHYDR_CYS

ALDH3B1 ALDH3B2

5.03e-03181112PS00070
DomainALDEHYDE_DEHYDR_GLU

ALDH3B1 ALDH3B2

5.03e-03181112PS00687
DomainPI3/4_kinase_cat_dom

PIK3CA PI4KA

5.03e-03181112IPR000403
DomainPI3_4_KINASE_3

PIK3CA PI4KA

5.03e-03181112PS50290
Domainig

HLA-DMA PDGFRB LRRC4 CNTN2 LRIT1

5.56e-031901115PF00047
DomainImmunoglobulin

HLA-DMA PDGFRB LRRC4 CNTN2 LRIT1

5.56e-031901115IPR013151
Domain-

ALDH3B1 ALDH3B2

5.60e-031911123.40.605.10
DomainAldedh

ALDH3B1 ALDH3B2

5.60e-03191112PF00171
DomainGOLD_dom

SEC14L6 SEC14L5

5.60e-03191112IPR009038
DomainAld_DH_C

ALDH3B1 ALDH3B2

5.60e-03191112IPR016163
DomainAld_DH_N

ALDH3B1 ALDH3B2

5.60e-03191112IPR016162
DomainAld_DH/histidinol_DH

ALDH3B1 ALDH3B2

5.60e-03191112IPR016161
DomainAldehyde_DH_dom

ALDH3B1 ALDH3B2

5.60e-03191112IPR015590
Domain-

ALDH3B1 ALDH3B2

5.60e-031911123.40.309.10
DomainGOLD

SEC14L6 SEC14L5

5.60e-03191112PS50866
Pubmed

Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking.

RHBDF1 RHBDF2

1.07e-052114235585977
Pubmed

Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium.

ABCA4 ATG7

1.07e-052114226468292
Pubmed

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

RHBDF1 RHBDF2

1.07e-052114223969955
Pubmed

Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.

RHBDF1 RHBDF2

1.07e-052114232646486
Pubmed

Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.

ALDH3B1 ALDH3B2

1.07e-05211429161417
Pubmed

Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.

ACE2 AGTR2

1.07e-052114234428252
Pubmed

Dihydroceramide-based response to hypoxia.

DEGS1 DEGS2

1.07e-052114221914808
Pubmed

Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways.

RHBDF1 RHBDF2

1.07e-052114231661139
Pubmed

Identification and characterization of a sphingolipid delta 4-desaturase family.

DEGS1 DEGS2

1.07e-052114211937514
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

ABCA4 ATG7 PDGFRB SUN1 RBP3 PIK3CA LARGE1

1.24e-05233114732290105
Pubmed

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

ATG7 PIK3CA PI4KA

2.26e-0517114325327288
Pubmed

Defining the membrane proteome of NK cells.

HLA-DMA PDGFRB ERAP1 DOCK8 MARS1 INTS1 XPO1 ECE1 PRPF8 DPM1 GNA13 PI4KA PAM DYNC1H1

2.95e-0511681141419946888
Pubmed

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

RHBDF1 RHBDF2

3.19e-053114228104813
Pubmed

The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity and the Presence of COVID-19-Related Retinopathy.

ACE2 AGTR2

3.19e-053114235885894
Pubmed

Angiotensin II and III suppress food intake via angiotensin AT(2) receptor and prostaglandin EP(4) receptor in mice.

PTGER4 AGTR2

3.19e-053114218258202
Pubmed

The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1.

IL13RA2 AGTR2

3.19e-05311429725226
Pubmed

Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.

ENPP1 KL

3.19e-053114228798354
Pubmed

Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population.

TSPYL1 TSPYL5

3.19e-053114228847364
Pubmed

Role of iRhoms 1 and 2 in Endochondral Ossification.

RHBDF1 RHBDF2

3.19e-053114233227998
Pubmed

G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling.

ITGA2B GNA13

3.19e-053114220075254
Pubmed

Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.

ATG7 TG

3.19e-053114237345654
Pubmed

Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars.

PIK3CA AGTR2

3.19e-053114216522324
Pubmed

ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).

RHBDF1 RHBDF2

3.19e-053114232060096
Pubmed

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.

DOK1 ITGA2B

3.19e-053114226790499
Pubmed

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.

RHBDF1 RHBDF2

3.19e-053114228432785
Pubmed

Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade.

ACE2 AGTR2

3.19e-053114224379178
Pubmed

Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.

ATG7 GRID2

3.19e-053114228502476
Pubmed

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.

RHBDF1 RHBDF2

3.19e-053114221439629
Pubmed

Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression.

XPO1 MAPK6

3.19e-053114212915405
Pubmed

Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice.

RHBDF1 RHBDF2

3.19e-053114237282854
Pubmed

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

RHBDF1 RHBDF2

3.19e-053114226535007
Pubmed

Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.

XPNPEP2 PTGER4 ACE2

3.20e-0519114321052031
Pubmed

Interactome of the Autoimmune Risk Protein ANKRD55.

MARS1 XPO1 PRPF8 DPM1 PI4KA DYNC1H1

4.91e-05197114631620119
Pubmed

Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.

ACE2 AGTR2

6.36e-054114227612496
Pubmed

Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets.

ITGA2B GNA13

6.36e-054114212183468
Pubmed

Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo.

PDGFRB PIK3CA

6.36e-05411428702949
Pubmed

Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.

PDGFRB PIK3CA

6.36e-054114212933652
Pubmed

Induction of autophagy in axonal dystrophy and degeneration.

ATG7 GRID2

6.36e-054114216885219
Pubmed

Targeting protein-protein interactions: a promising avenue of anti-HIV drug discovery.

APOBEC3G XPO1

6.36e-054114220712566
Pubmed

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.

CNTNAP1 PTPRB

6.36e-05411429118959
Pubmed

Angiotensin-converting enzyme 2 protects from severe acute lung failure.

ACE2 AGTR2

6.36e-054114216001071
Pubmed

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.

RHBDF1 RHBDF2

6.36e-054114225918388
Pubmed

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation.

PDGFRB ITGA2B

6.36e-054114216690964
Pubmed

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.

ALDH3B1 ALDH3B2

6.36e-054114225286108
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

IL13RA2 HLA-DMA PTGER4 NFATC4 PIK3CA AGTR2 NFRKB HRH4 ALDH3B1 ALDH3B2 LRIT1

8.68e-058241141120237496
Pubmed

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

RHBDF1 RHBDF2

1.06e-045114229897336
Pubmed

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

RHBDF1 RHBDF2

1.06e-045114229897333
Pubmed

The lipid-binding SEC14 domain.

SEC14L6 SEC14L5

1.06e-045114217428729
Pubmed

Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets.

ITGA2B GNA13

1.06e-045114212297512
Pubmed

Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.

ITGA2B GNA13

1.06e-045114223640884
Pubmed

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

PIK3CA PI4KA

1.06e-04511428246987
Pubmed

Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.

DOK1 PDGFRB

1.06e-04511429737977
Pubmed

Integrin αIIb-mediated PI3K/Akt activation in platelets.

ITGA2B PIK3CA

1.06e-045114223082158
Pubmed

Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men.

ERAP1 CNR2

1.06e-045114217390085
Pubmed

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

AVPR1B ACE2

1.06e-045114233713620
Pubmed

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.

ABCA4 ABCG8

1.58e-046114212111378
Pubmed

Gene frequency of human platelet alloantigens-1 to -6 and -15 in Saudi blood donors.

HPSE2 ITGA2B

1.58e-046114227019315
Pubmed

Interactions among related genes of renin-angiotensin system associated with type 2 diabetes.

ACE2 AGTR2

1.58e-046114220592051
Pubmed

Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice.

ACE2 AGTR2

1.58e-046114218192335
Pubmed

The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins.

PDGFRB PIK3CA

1.58e-046114215377662
Pubmed

Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue.

ACE2 AGTR2

1.58e-046114233339432
Pubmed

Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.

HLA-DMA APOBEC3G XPO1

1.74e-0433114316354571
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

SYT12 ERAP1 DOCK8 CNTNAP1 OAS1 GRID2 SLC6A11 GNA13 DYNC1H1

2.14e-04621114922794259
Pubmed

Autophagy protects the retina from light-induced degeneration.

ABCA4 ATG7

2.21e-047114223341467
Pubmed

Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus-Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia.

PDGFRB PIK3CA

2.21e-047114225569182
Pubmed

Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.

PIK3CA PI4KA

2.21e-047114217242350
Pubmed

ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.

PDGFRB ITGA2B

2.21e-047114223091165
Pubmed

Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.

CNTNAP1 CNTN2

2.21e-047114219458237
Pubmed

Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.

CNTNAP1 CNTN2

2.21e-047114212975355
Pubmed

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

XPO1 DPM1 TTLL12 DYNC1H1

2.25e-0490114428978906
Pubmed

Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.

USP34 SUN1 XPO1

2.46e-0437114334147029
Pubmed

Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk.

ACE2 AGTR2

2.94e-048114219716087
Pubmed

The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.

RHBDF1 RHBDF2

2.94e-048114234613632
Pubmed

Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells.

ITGA2B AGTR2

2.94e-048114233480126
Pubmed

The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse.

ACE2 AGTR2

2.94e-048114225249154
Pubmed

Dissociation of heterotrimeric g proteins in cells.

AVPR1B GNA13 AGTR2 HRH4 CNR2

3.19e-04179114518577758
Pubmed

Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.

PIK3CA CNTN2

3.78e-049114218367611
Pubmed

Typing recombinant inbred mouse strains for microsatellite markers.

ENPP1 TG

3.78e-04911428507976
Pubmed

25 years of HIV-1 research - progress and perspectives.

APOBEC3G XPO1

3.78e-049114218976462
Pubmed

Mapping of transcription start sites of human retina expressed genes.

ABCA4 RBP3 LRIT1

4.40e-0445114317286855
Pubmed

Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling.

PDGFRB NFATC4

4.71e-0410114219710169
Pubmed

HDAC6 interacts with PTPN1 to enhance melanoma cells progression.

ERAP1 CNTNAP1

4.71e-0410114229278704
Pubmed

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

XPO1 PRPF8 DPM1 MAPK6

5.01e-04111114432683582
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

SFTPB RBP3 DYNC1H1

5.01e-044711438812413
Pubmed

Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.

ACE2 NFATC4 AGTR2

5.01e-0447114317198697
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

KCTD19 DOCK8 XPO1 PI4KA KDM2B

5.17e-04199114536688959
Pubmed

Charcot-Marie-Tooth Hereditary Neuropathy Overview

MARS1 CNTNAP1 DYNC1H1

5.33e-0448114320301532
Pubmed

Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.

CNTNAP1 CNTN2

5.75e-0411114218650339
Pubmed

Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.

PDGFRB PIK3CA

5.75e-0411114216135792
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

VMP1 USP34 RHBDD1 SYT12 ERAP1 ENPP1 SUN1 CNTNAP1 LAMB2 ECE1 DEGS1 PAM

5.91e-0412011141235696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

VMP1 USP34 RHBDD1 PDGFRB MARS1 SUN1 CNTNAP1 INTS1 LAMB2 XPO1 PRPF8 DEGS1

5.99e-0412031141229180619
Pubmed

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

ERAP1 PTGER4

6.88e-0412114221743469
Pubmed

Host proteins involved in HIV infection: new therapeutic targets.

APOBEC3G XPO1

6.88e-0412114220018238
Pubmed

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.

PAM DYNC1H1

6.88e-0412114229293652
Pubmed

Abnormal development of the intercostal muscles and the rib cage in Myf5-/- embryos leads to pulmonary hypoplasia.

PDGFRB SFTPB

6.88e-0412114215580568
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

USP34 INTS1 BTBD1 ECE1 PI4KA DYNC1H1

6.94e-04322114626514267
Pubmed

Global landscape of HIV-human protein complexes.

DOK1 MARS1 SUN1 CNTNAP1 XPO1 MAPK6 DYNC1H1

7.95e-04457114722190034
Pubmed

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure.

CNTNAP1 CNTN2

8.11e-0413114215601927
Pubmed

Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse.

CNTNAP1 CNTN2

8.11e-0413114236793543
Pubmed

Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning.

SERPINF2 CNTN2

8.11e-0413114229618843
InteractionCACNG4 interactions

RHBDF2 C2CD2 PLEKHH3 GNA13 PI4KA ALDH3B1

6.24e-07591056int:CACNG4
GeneFamilyRhomboid family

RHBDD1 RHBDF1 RHBDF2

2.14e-0514723926
GeneFamilyGlycosyltransferase family 2

DPM1 HAS1

2.32e-046722428
GeneFamilySEC14 family|PRELI domain containing

SEC14L6 SEC14L5

2.32e-0467221063
GeneFamilyFatty acid desaturases

DEGS1 DEGS2

4.31e-048722553
GeneFamilyINO80 complex |SRCAP complex

INO80C NFRKB

1.59e-0315722595
GeneFamilyAminopeptidases|CD molecules

ERAP1 XPNPEP2

2.05e-0317722104
GeneFamilyAldehyde dehydrogenases

ALDH3B1 ALDH3B2

2.56e-0319722398
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PDGFRB LRRC4 CNTN2 LRIT1

3.90e-03161724593
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF1 RHBDF2 DOCK8 FAM83E LAMB2 OAS1 FRK MAP4K2

4.87e-082001148aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF1 RHBDF2 DOCK8 FAM83E LAMB2 OAS1 FRK MAP4K2

4.87e-082001148a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOK1 RHBDF1 PDGFRB DOCK8 HPSE2 GRID2 C2CD2

2.32e-0716511474f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOK1 RHBDF1 PDGFRB DOCK8 HPSE2 GRID2 C2CD2

2.32e-071651147cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HPSE2 GRID2 MRGPRG CHRNA10 ABCG8 SEC14L5

1.45e-0613711464dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HPSE2 GRID2 MRGPRG CHRNA10 ABCG8 SEC14L5

1.45e-061371146c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCelldroplet-Fat-Bat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNK1 TMEM141 MPV17L B3GNT8 TG FRK

4.74e-0616811466fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCelldroplet-Fat-Bat-18m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNK1 TMEM141 MPV17L B3GNT8 TG FRK

4.74e-061681146794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCelldroplet-Fat-Bat-18m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNK1 TMEM141 MPV17L B3GNT8 TG FRK

4.74e-0616811461e23b634f96e88b976a523ca1f3fc08f6fe9b239
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ABCA4 ENPP1 CALHM6 XPNPEP2 FRK NFATC4

6.60e-061781146cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCellremission-B_naive|World / disease stage, cell group and cell class

CFAP251 HLA-DMA ENPP1 CALHM6 CNR2 LARGE1

7.49e-061821146cc1dfd2de35aee1a26f7efd78e108b60a3556ec5
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IL13RA2 ABCA4 ENPP1 CALHM6 XPNPEP2 NFATC4

7.97e-061841146235890e8b424f4386b6ea52d173d20a00898df73
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP34 PDGFRB ECE1 PTPRB DEGS2 MAP4K2

1.21e-0519811460a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RHBDF2 HLA-DMA DOCK8 OAS1 PTGER4 GNA13

1.25e-051991146e245851a5bddf56f7e13a7fb7c5fda2fd275dae3
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Rgs5_(Mural.Rgs5Acta2.Rgs5)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ACE2 FRK NFATC4 CNR2

2.98e-05691144a157b1582401cebd222343d94086dbea876140c2
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Rgs5_(Mural.Rgs5Acta2.Rgs5)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ACE2 FRK NFATC4 CNR2

2.98e-05691144cdd42abdd072aa438830d837ee857529269a81e0
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF22-AS1 CNTNAP1 LAMB2 ZNF804A HSD3B7

3.47e-051441145f769be4da268980ea7c06d7097ec39d06777e675
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HGD MPV17L DEGS2 SERPINF2 CNR2

5.41e-051581145ab707bfe782c667b252b488ad1d7efd49cf0a899
ToppCellControl-Myeloid-Monocytes,_Macrophages-Mast-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLHL6 DOCK8 HACD4 SWSAP1 TTLL12

5.57e-05159114581782e9e370558d61af5e0c760ac9759d69fb725
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C9orf40 MPV17L OAS1 ACE2 SEC14L5

5.91e-0516111459cfbbcd38ec2e75376bbc26001964b6991ad0e21
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Thalamus / BrainAtlas - Mouse McCarroll V32

HPSE2 ACE2 FRK SEBOX

6.16e-058311444017af9a4804a06d0f2cd0f285ebf1b582b751de
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Car4_(Mural.Rgs5Acta2.Car4)|Thalamus / BrainAtlas - Mouse McCarroll V32

HPSE2 ACE2 FRK SEBOX

6.16e-0583114459fce941d45f9763a8584f3fd5b7c0738de9f592
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Car4_(Mural.Rgs5Acta2.Car4)-|Thalamus / BrainAtlas - Mouse McCarroll V32

HPSE2 ACE2 FRK SEBOX

6.16e-05831144ebabce70dc01fdeda7fccebc2c4a0b686cda580f
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CFAP251 HLA-DMA KCTD19 OAS1 SERPINF2

6.83e-0516611459fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCellfacs-Marrow-T_cells-18m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HPSE2 HACD4 LRRC27 HRH4 ALDH3B1

6.83e-051661145fab4da2537904ad114218f720e18a600f14a00a1
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TG FRK NFATC4 CNR2

7.07e-0586114480aa7f0a7e43f8278b1af25ced8c069325ed3270
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM83E ACE2 DEGS2 ALDH3B2 ABCG8

7.43e-05169114508ac28c5ad8f5c5f9f54af341bf39e8f9417636e
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SFTPB ENPP1 ECE1 CHRNA10 SERPINF2

7.43e-051691145e3410ccb3f85811c75694e286115803911169a2f
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SFTPB ENPP1 ECE1 CHRNA10 SERPINF2

7.43e-051691145a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM83E ACE2 DEGS2 ALDH3B2 ABCG8

7.43e-051691145e5abd41db1e6724ad900e37658fa063b8e522908
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHBDF2 HLA-DMA DOCK8 MPV17L CALHM6

8.08e-051721145d40a8bd61114b49a5837c836136a13c37c8f7de0
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM83E ECE1 KL PTPRB LRRC27

8.08e-051721145fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM83E ECE1 KL PTPRB LRRC27

8.08e-051721145745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB LAMB2 ACE2 FRK NFATC4

8.30e-0517311452415b6ff49f334da570577d4e93484d024a3dbd5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB LAMB2 ACE2 FRK NFATC4

8.30e-0517311452acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMB2 HPSE2 XPNPEP2 SWSAP1 HAS1

8.53e-0517411451d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 ECE1 HSD3B7 PTPRB PAM

8.76e-0517511452e54961846c65b185d9bd6e305dd81205579d890
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HACD4 ITGA2B GTF2H3 FCRLB HRH4

8.76e-0517511451b35acece23712ab7e3f92d9d68266efd38b3ef5
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 ECE1 HSD3B7 PTPRB PAM

8.76e-051751145efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HACD4 ITGA2B GTF2H3 FCRLB HRH4

8.76e-051751145a9f88054e2c28d604c65ed785f63021aadb7f4c8
ToppCellControl-B_cells|Control / group, cell type (main and fine annotations)

KLHL6 RHBDD1 DOCK8 ZNF804A CNR2

9.00e-0517611459125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ABCA4 DOCK8 OAS1 PTPRB MAP4K2

9.75e-051791145ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ABCA4 DOCK8 OAS1 PTPRB MAP4K2

9.75e-05179114535fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-DC1|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-DMA AVPR1B ENPP1 CALHM6 SERPINF2

1.00e-041801145a7db1f00566c9acab8b239cbf2e053fb3f2f6a0d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 RHBDF2 DOCK8 ZNF804A CNR2

1.03e-0418111455a4fe0eca7cbc9cbc8a2fdbe795a7c5f4052a659
ToppCellremission-B_naive|remission / disease stage, cell group and cell class

CFAP251 HLA-DMA CALHM6 CNR2 LARGE1

1.08e-041831145280d55d67f1d44594206da2f3a332c9d799dbdf0
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)|Striatum / BrainAtlas - Mouse McCarroll V32

ACE2 FRK NFATC4 SEBOX

1.09e-04961144d98df92856840602a82d3f050bf0a1543445cac0
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)-|Striatum / BrainAtlas - Mouse McCarroll V32

ACE2 FRK NFATC4 SEBOX

1.09e-04961144bf62c29da66aa3eefdc59337dfb3cd0467f04f10
ToppCell15-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

KLHL6 HGD HLA-DMA DOCK8 CNR2

1.11e-041841145c294cd421f277992b56ae9c40b8f3948e33148fe
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IL13RA2 ABCA4 XPNPEP2 KL

1.13e-049711442cd5cafdf0a9a468baaafd4613d790fc048ee53e
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IL13RA2 ABCA4 XPNPEP2 KL

1.13e-04971144adda7a49b7754ed110e212346768bf52107c26fc
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IL13RA2 ABCA4 XPNPEP2 KL

1.13e-049711446d865ec3a413f595de17e0a5f8c61666ebb3e252
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KLHL6 HLA-DMA DOCK8 ANTXRL CNR2

1.14e-0418511458fc357ee041bfd588986730a52ea2021b5f88941
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-lymphatic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK8 OAS1 ITGA2B PTPRB MAP4K2

1.17e-0418611455d94e6dd2c92e0c46badeb1e6eb54b69af855a66
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK8 OAS1 ITGA2B PTPRB MAP4K2

1.17e-0418611451da52e13096dfe4eb08bd0e7461cb3809b3b3deb
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT12 SFTPB SRD5A1 ACE2 DEGS2

1.20e-04187114574112df9b34051ae5cd2427ccfa3399eccff0076
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB DOCK8 GRID2 C2CD2 LARGE1

1.20e-041871145ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB DOCK8 GRID2 C2CD2 KCNT1

1.20e-04187114548bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB DOCK8 GRID2 C2CD2 LARGE1

1.20e-041871145530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCellfacs-Lung-EPCAM-24m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT12 SFTPB SRD5A1 ACE2 DEGS2

1.20e-041871145214ce9b55fd6ce2fe7bd4cf4b1383517f5f0d759
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB DOCK8 GRID2 C2CD2 KCNT1

1.20e-041871145958402fcc78f4c7a7d13d659d776f3817137975f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB DOCK8 GRID2 C2CD2 KCNT1

1.26e-041891145fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCelldroplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB HPSE2 ZNF804A PLEKHH3 NDST3

1.29e-041901145e04f47705851563515b6a66a2634cf7a574f7bda
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZNF804A PLEKHH3 NDST3 NFATC4

1.29e-0419011451803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCellB_cell_maturation|World / Lineage and Cell class

RHBDF2 HLA-DMA CALHM6 CNR2 LARGE1

1.29e-041901145301782283d0c604fb3b428a8ddf1f7cd8e63a90b
ToppCellCOVID-19-Myeloid-DC1|Myeloid / Condition, Lineage and Cell class

TNK1 KCTD19 ENPP1 SERPINF2 CNR2

1.32e-0419111454be3c6287965fe3a2f109d26f68bdc2fa393f99b
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

KLHL6 ATG7 DOCK8 SLC22A15 ZNF804A

1.32e-041911145dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellB_cell_maturation-Naive_B_cell|World / Lineage and Cell class

RHBDF2 HLA-DMA CALHM6 CNR2 LARGE1

1.35e-04192114558267a11c938a380c6e26f4e4ce63f3b4be79fdc
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HGD XPNPEP2 ACE2 KL SERPINF2

1.35e-0419211453e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCellParenchymal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ENPP1 NFATC4 IGKV3D-20 TSPYL5 KCNT1

1.39e-041931145df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCellParenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ENPP1 NFATC4 IGKV3D-20 TSPYL5 KCNT1

1.39e-041931145ab36d684bde8fe77d11a5188425135328052c58b
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB LAMB2 PLEKHH3 NDST3 NFATC4

1.42e-04194114580be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCell(4)_Endothelial_cells-(4)_Lymph_vessel|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

ABCA4 CALHM6 NDST3 DEGS2 MAP4K2

1.42e-0419411459735b86d3b2480a0b34d8aab8e7bd609d83c2454
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 RHBDF2 DOCK8 ZNF804A GNA13

1.45e-04195114562dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HLA-DMA KCTD19 HACD4 XPNPEP2 SERPINF2

1.45e-041951145cb27f6ca8b02438c353c9dff2f76d2656bb5b29a
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFRB OAS1 HPSE2 ECE1 AGTR2

1.45e-041951145bad7f2162000f29488b3c4b903dcac9a818621f7
ToppCellmetastatic_Brain-Myeloid_cells-CD163+CD14+_DCs|metastatic_Brain / Location, Cell class and cell subclass

HLA-DMA HACD4 CALHM6 PTGER4 HAS1

1.49e-0419611453cd96d5729b7030ba57f21f5231096d93ef30e56
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 RHBDF2 ATG7 DOCK8 GNA13

1.53e-0419711458af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KLHL6 HLA-DMA CALHM6 PTGER4 GNA13

1.53e-041971145e27577a1fa553986044512f52c252a587f864510
ToppCellLPS_only-Hematopoietic_Myeloid-Dendritic_cells|LPS_only / Treatment groups by lineage, cell group, cell type

DOCK8 SRD5A1 PTGER4 CNTN2 CNR2

1.53e-04197114559ddd8ff7dddf3747b988374e1a4d80959db803e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KLHL6 RHBDF2 HLA-DMA DOCK8 GNA13

1.60e-041991145b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets|Control_saline / Treatment groups by lineage, cell group, cell type

HGD RHBDF1 HACD4 ITGA2B SEC14L5

1.60e-04199114586d4e5dd3bcc6bafa48fd0211dad39a2456b53be
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 DOCK8 OAS1 PTGER4 MAP4K2

1.64e-0420011450eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

HGD ANKRD9 HACD4 ITGA2B SEC14L5

1.64e-042001145e4be88bcef2738915f711b32c95e9c613e7edf96
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 DOCK8 OAS1 PTGER4 MAP4K2

1.64e-04200114501d707c4f8ee0daac635b7260937b1baebc6fc23
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

VMP1 RHBDF2 DOCK8 XPO1 DYNC1H1

1.64e-042001145e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 DOCK8 OAS1 XPO1 DYNC1H1

1.64e-04200114512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Lmcd1_(Mural.Rgs5Acta2.Lmcd1)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IL13RA2 ACE2 NFATC4 SEBOX

1.65e-0410711440b45241cc52d10225966b49941efb66997184158
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Lmcd1_(Mural.Rgs5Acta2.Lmcd1)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IL13RA2 ACE2 NFATC4 SEBOX

1.65e-0410711442f84089acc794b43ee59452dc8f90ca7261ebd41
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA2B RANBP17 HAS1

1.69e-0442114356bbec86001d43cc2c71d4dcd70b22ea41963fad
Diseasebreast angiosarcoma (is_implicated_in)

PTPRB PIK3CA

3.90e-0531072DOID:4511 (is_implicated_in)
Diseasehypertension (biomarker_via_orthology)

ATG7 PDGFRB ECE1 ACE2 KL AGTR2

1.84e-042271076DOID:10763 (biomarker_via_orthology)
DiseaseSjogren-Larsson syndrome (implicated_via_orthology)

ALDH3B1 ALDH3B2

1.94e-0461072DOID:14501 (implicated_via_orthology)
Diseaseprostate cancer (implicated_via_orthology)

PDGFRB SRD5A1 PRPF8

2.34e-04331073DOID:10283 (implicated_via_orthology)
DiseaseColorectal Carcinoma

ABCA4 SLC22A15 RBP3 GRID2 LRRC4 ZNF804A NDST3 KL SACS PIK3CA

2.41e-0470210710C0009402
Diseasedilated cardiomyopathy (is_marker_for)

IL13RA2 ECE1 AGTR2

3.85e-04391073DOID:12930 (is_marker_for)
DiseaseCharcot-Marie-Tooth disease

MARS1 CNTNAP1 DYNC1H1

4.80e-04421073cv:C0007959
Diseaserespiratory syncytial virus infectious disease (is_implicated_in)

SFTPB ACE2

5.75e-04101072DOID:1273 (is_implicated_in)
DiseaseAnkylosing spondylitis

ERAP1 PTGER4

7.01e-04111072C0038013
DiseaseMalformations of Cortical Development

PIK3CA DYNC1H1

1.15e-03141072C1955869
DiseaseCortical Dysplasia

PIK3CA DYNC1H1

1.15e-03141072C0431380
Diseasemyelodysplastic syndrome (implicated_via_orthology)

ATG7 PRPF8

1.33e-03151072DOID:0050908 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease type 2

MARS1 DYNC1H1

1.71e-03171072cv:C0270914
Diseasebipolar disorder, schizophrenia, response to lithium ion

HLA-DMA ZNF804A

2.37e-03201072GO_0010226, MONDO_0004985, MONDO_0005090
DiseaseRetinitis pigmentosa

ABCA4 RBP3 PRPF8

2.49e-03741073cv:C0035334
DiseaseCOVID-19 (is_implicated_in)

ACE2 SERPINF2

2.62e-03211072DOID:0080600 (is_implicated_in)
Diseasecolorectal carcinoma (is_implicated_in)

PTPRB PIK3CA

2.87e-03221072DOID:0080199 (is_implicated_in)
Diseaselung disease (is_marker_for)

SFTPB CNTN2

2.87e-03221072DOID:850 (is_marker_for)
Diseaseaspartate measurement

TTLL12 NDST3

3.41e-03241072EFO_0010462
Diseaseglioblastoma (is_implicated_in)

PDGFRB PTPRB

3.41e-03241072DOID:3068 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
IPSSLVWRPDIVLYN

CHRNA10

106

Q9GZZ6
FTARYIRIVPLAWNP

CNTNAP1

141

P78357
FRNWLYFVPLLLLVP

ANTXRL

351

A6NF34
FLVLIWLRNANPLYS

ABCA4

36

P78363
RTYPLRWFLLEQPEI

SERPINF2

271

P08697
LFEPWNNLPKYYILL

APOBEC3G

171

Q9HC16
QWLLRPLVLYAPLLN

HSD3B7

306

Q9H2F3
GLVLIIAPWNYPLNL

ALDH3B1

106

P43353
IAPWNYPLNLTLVPL

ALDH3B1

111

P43353
VIYPFLSQRRNPWQA

AGTR2

146

P50052
YWLANLRPGLQPFLL

ABCG8

516

Q9H221
NILYAWARNAPPTRL

PAM

131

P19021
LVLIIAPWNYPLNLT

ALDH3B2

26

P48448
APWNYPLNLTLVLLV

ALDH3B2

31

P48448
LPTYNERENLPLIVW

DPM1

31

O60762
WYPPLTRELFLLICN

CFAP251

801

Q8TBY9
ELFPLIPNDYLLSWL

CNR2

181

P34972
LGYLYLQWQPPLSLD

IL13RA2

46

Q14627
HIERWLVYFPPFQLL

NDST3

751

O95803
PTYLPLLQNAVERWY

RANBP17

746

Q9H2T7
KYPELLSNPQRVYWI

KCTD19

416

Q17RG1
AALPTSLLLLQWYEP

MAP4K2

616

Q12851
QWLPRDALTVFNPYN

PTPRB

1296

P23467
PFLVYQLPCFWNVQL

LARGE1

346

O95461
YVLENVRLPLLDPWY

KLHL6

256

Q8WZ60
WYQQKPGLAPRLLIY

IGKV3D-20

56

A0A0C4DH25
PNWAELVLPALQYLA

NFRKB

421

Q6P4R8
YQWLLRDLPRLPLFD

INTS1

1026

Q8N201
LPAWLQPRYRKNAYL

HACD4

6

Q5VWC8
LYLPLWDALSYLNEP

GLB1L3

416

Q8NCI6
PLRNLFIPVFLNCWL

KCNT1

211

Q5JUK3
RNPVGYPLAWQFLRK

ERAP1

841

Q9NZ08
GLLVYLLNWLNPPRL

GRID2

581

O43424
WYRSPRLLLSPNNYT

MAPK6

196

Q16659
RIASVNPILDPWIYI

PTGER4

316

P35408
ERLITWYNPLSAPEL

PI4KA

1501

P42356
FPPISYLNAISWRII

MVD

271

P53602
ELWLRNNPIESIPSY

LRRC4

151

Q9HBW1
YDLLLRLEPQVPEQW

LAMB2

621

P55268
RIEPLTFYLDPQWQL

ENPP1

506

P22413
TFYLDPQWQLALNPS

ENPP1

511

P22413
VFLQYLPAIRALWAD

GNA13

141

Q14344
LPPQYALELLTVYAW

OAS1

226

P00973
LVDQNFNPLPDYWLS

HPSE2

431

Q8WWQ2
WLNYDIYIPDLPRAA

PIK3CA

386

P42336
PLGRLEQLWLPYNAL

LRIT1

81

Q9P2V4
FYWSLQPLLNFLLPV

MRGPRG

216

Q86SM5
RALPWQLNDPNYFSI

INO80C

116

Q6PI98
QRLWEYLEPYLPCLS

FRK

6

P42685
FWLIPPTLHNLALYE

KDM2B

261

Q8NHM5
NLAQYPGWPLRNFLV

ATG7

236

O95352
LYLAQWALARARPQP

C2CD2

31

Q9Y426
LGYSWLPILLNERLQ

DOCK8

666

Q8NF50
QSQILEPLLSWPYTL

DOK1

191

Q99704
AWNLPYGLVFLLVPA

CALHM6

46

Q5R3K3
PLLPLQREPLYNWQA

BTBD1

36

Q9H0C5
WILCPQPLGDYQQLL

C19orf67

301

A6NJJ6
YWVPRNALPSDLLEN

HLA-DMA

216

P28067
IWVILQPLFYAFRPL

DEGS1

161

O15121
PARKLLWLVLQPFFY

DEGS2

156

Q6QHC5
LWLVLQPFFYSLRPL

DEGS2

161

Q6QHC5
VRPLLNYFEPLFTWL

ACE2

581

Q9BYF1
AFYQAVRDLLPVWLL

ANKRD9

36

Q96BM1
YRWLLNEFPNFIPTD

CNTN2

166

Q02246
LAANYVPLLPLALWA

HAS1

496

Q92839
LLEKQRFQFPPSWLY

DYNC1H1

1196

Q14204
QPVVTLYHWDLPQRL

KL

186

Q9UEF7
INWLPFLNTIFYPVE

ECE1

346

P42892
NTFQYWRNPLPPIDL

C9orf40

151

Q8IXQ3
SNDWLILQVPYAPVF

FCRLB

101

Q6BAA4
RLGQTIPLPFAYWNQ

B3GNT8

61

Q7Z7M8
LSLFIPESPRWLYSQ

SLC22A15

241

Q8IZD6
WLPVLGFLQLPYLDS

RNF103

371

O00237
LQTWQPPALLEEFYA

SEC14L5

301

O43304
PNPDDYFLLRWLQAR

SEC14L6

31

B5MCN3
ILAWQPPEVVRLYNA

SEC14L6

71

B5MCN3
NIIRWLYSNQIPASP

SACS

1361

Q9NZJ4
NWLQPTAELPFPQLY

PHYHD1

276

Q5SRE7
QLPYDSTWELPRDQL

PDGFRB

586

P09619
LANPRDFLIPIAWYE

HGD

221

Q93099
LQWFNSFVNPLLYPL

HRH4

346

Q9H3N8
LDLPLQPFSGWLYLQ

SYT12

261

Q8IV01
LPATQDPAALRYWQL

PLEKHH3

321

Q7Z736
ALNIWFFLNPQKPLY

RHBDD1

36

Q8TEB9
LSEQQFPIPLPYCWL

SFTPB

196

P07988
WVPVYLLLDRQQLPA

FAM83E

181

Q2M2I3
VLLSLPRNYYIQWLN

LMBR1L

91

Q6UX01
FFQLLPNLTWLDLRY

LRRC27

86

Q9C0I9
LDWPLPSQYEQLELR

NFATC4

406

Q14934
IPAIPSRIWYLYLQN

KERA

66

O60938
NPEVPDQFYRLWLSL

RHBDF1

646

Q96CC6
ALLQRYFPAQCWLQP

SWSAP1

156

Q6NVH7
LLELERAFAAWPYPN

SEBOX

31

Q9HB31
VLAFLWLPSLYQRPL

ITGA2B

936

P08514
WLPSLYQRPLDQFVL

ITGA2B

941

P08514
EDQLIPNLYRYIQPW

PRPF8

1361

Q6P2Q9
LETLLRFLNWIPLGY

XPO1

226

O14980
FQVLPQLLWDITYRF

AVPR1B

86

P47901
QLLWDITYRFQGPDL

AVPR1B

91

P47901
WQYLNPPQRTLYRDV

ZNF182

41

P17025
LAPYVLRQVWEPLQD

RBP3

456

P10745
NFNYVWLRLLERALP

MPV17L

61

Q2QL34
IKEDLWPNPLQYYLL

TSPYL1

396

Q9H0U9
WPNPLQYYLLREGVR

TSPYL1

401

Q9H0U9
LYPDLSRLSDPQVWV

SLC6A11

286

P48066
WLPRTFNLRTELPQF

TTLL12

386

Q14166
FIQRKFPYPLQWSLL

TMEM141

51

Q96I45
QFYWPILEELNVTRP

TNK1

21

Q13470
RPCFYLNWQDIPILT

TRIM49D1

36

C9J1S8
WVVQELPSLALPLYQ

SRD5A1

56

P18405
IPLWYFSQSPRVVIQ

SUN1

646

O94901
AWLFNLRASDIPYNP

XPNPEP2

246

O43895
PPFASYILQRIWEVI

USP34

2621

Q70CQ2
ETAYFPQILRFLRPW

ZNF22-AS1

56

Q5T742
DLWPNPLQYYLLGDR

TSPY26P

316

Q9H489
LNPEVPDQFYRLWLS

RHBDF2

646

Q6PJF5
QPRENILLEPYLFWQ

TG

856

P01266
IVLWGALYPLLQDPA

MARS1

146

P56192
PSLLQYLLWVFLPDQ

GTF2H3

221

Q13889
EELWPNPLQFYLLSE

TSPYL5

371

Q86VY4
WLRYNSGILNTQPPL

ZNF804A

991

Q7Z570
LWRQPLITLQYFSLE

VMP1

46

Q96GC9