Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH7 MYH13 MYO5B MYH15 TNNT2	3.93e-08	38	103	6	GO:0000146
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH1 MYH7 MYH13 MYO5B MYH15 TNNT2	3.36e-05	118	103	6	GO:0003774
GeneOntologyMolecularFunction	actin binding	MYH1 MYH7 KLHL1 MYH13 MYO5B SYNE1 PLEKHG3 MYH15 DMD TNNT2 PPP1R42	3.69e-05	479	103	11	GO:0003779
GeneOntologyMolecularFunction	lamin binding	SYNE1 PPP4C DMD	1.22e-04	19	103	3	GO:0005521
GeneOntologyMolecularFunction	calmodulin binding	MYH1 MYH7 MYH13 MYO5B USP6 ASPM MYH15	1.91e-04	230	103	7	GO:0005516
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	DLG5 CAND1 MYO5B SYNE1 DDR2 ATL3 DHX33 NPHP4 DCTN1 RUFY3 EHD2 PTPN5 NF1 AMIGO3 RAPGEF3 MCU EHD1 ERC2 FLRT2 DMD	8.75e-06	1366	101	20	GO:0051130
GeneOntologyBiologicalProcess	ribophagy	ARMC3 RB1CC1	2.37e-05	2	101	2	GO:0034517
GeneOntologyCellularComponent	myosin filament	MYH1 MYH7 MYH13 MYH15	6.49e-06	25	103	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH7 MYH13 MYH15	1.04e-05	28	103	4	GO:0016460
GeneOntologyCellularComponent	myosin complex	MYH1 MYH7 MYH13 MYO5B MYH15	1.07e-05	59	103	5	GO:0016459
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH7 MYH13	6.21e-05	16	103	3	GO:0005859
GeneOntologyCellularComponent	cell cortex region	MYO5B DCTN1 ERC2 PRKCZ	7.09e-05	45	103	4	GO:0099738
GeneOntologyCellularComponent	ciliary pocket membrane	EHD3 EHD1	7.19e-05	3	103	2	GO:0020018
GeneOntologyCellularComponent	ciliary pocket	EHD3 EHD1	7.19e-05	3	103	2	GO:0020016
GeneOntologyCellularComponent	myofibril	MYH1 MYH7 MYH13 SYNE1 MYH15 DMD TNNT2	4.09e-04	273	103	7	GO:0030016
GeneOntologyCellularComponent	axon	TRPA1 RASGRF1 DCTN1 RUFY3 PTPN5 C1QL1 OPTN NF1 SACS RAPGEF3 ERC2 PRKCZ DMD	4.33e-04	891	103	13	GO:0030424
GeneOntologyCellularComponent	contractile muscle fiber	MYH1 MYH7 MYH13 SYNE1 MYH15 DMD TNNT2	5.86e-04	290	103	7	GO:0043292
GeneOntologyCellularComponent	recycling endosome	MYO5B EHD3 EHD2 USP6 OPTN EHD1	8.14e-04	222	103	6	GO:0055037
GeneOntologyCellularComponent	apical cortex	MYO5B PRKCZ	1.05e-03	10	103	2	GO:0045179
Domain	IQ	MYH1 MYH7 MYH13 RASGRF1 MYO5B PPEF1 ASPM MYH15	4.49e-08	93	103	8	PS50096
Domain	Myosin-like_IQ_dom	MYH1 MYH7 MYH13 ASPM MYH15	5.06e-08	19	103	5	IPR027401
Domain	-	MYH1 MYH7 MYH13 ASPM MYH15	5.06e-08	19	103	5	4.10.270.10
Domain	IQ	MYH1 MYH7 MYH13 RASGRF1 MYO5B PPEF1 ASPM	3.14e-07	81	103	7	SM00015
Domain	IQ_motif_EF-hand-BS	MYH1 MYH7 MYH13 RASGRF1 MYO5B PPEF1 ASPM	6.48e-07	90	103	7	IPR000048
Domain	Myosin_N	MYH1 MYH7 MYH13 MYH15	1.14e-06	15	103	4	PF02736
Domain	Myosin_N	MYH1 MYH7 MYH13 MYH15	1.14e-06	15	103	4	IPR004009
Domain	EHD_N	EHD3 EHD2 EHD1	1.62e-06	5	103	3	IPR031692
Domain	EHD_N	EHD3 EHD2 EHD1	1.62e-06	5	103	3	PF16880
Domain	Myosin_head_motor_dom	MYH1 MYH7 MYH13 MYO5B MYH15	2.01e-06	38	103	5	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH7 MYH13 MYO5B MYH15	2.01e-06	38	103	5	PS51456
Domain	Myosin_head	MYH1 MYH7 MYH13 MYO5B MYH15	2.01e-06	38	103	5	PF00063
Domain	MYSc	MYH1 MYH7 MYH13 MYO5B MYH15	2.01e-06	38	103	5	SM00242
Domain	Myosin_tail_1	MYH1 MYH7 MYH13 MYH15	2.52e-06	18	103	4	PF01576
Domain	Myosin_tail	MYH1 MYH7 MYH13 MYH15	2.52e-06	18	103	4	IPR002928
Domain	IQ	MYH1 MYH13 RASGRF1 MYO5B PPEF1 ASPM	2.60e-06	71	103	6	PF00612
Domain	EF-hand_4	EHD3 EHD2 EHD1	1.90e-05	10	103	3	PF12763
Domain	EH	EHD3 EHD2 EHD1	2.60e-05	11	103	3	PS50031
Domain	EH	EHD3 EHD2 EHD1	2.60e-05	11	103	3	SM00027
Domain	EH_dom	EHD3 EHD2 EHD1	2.60e-05	11	103	3	IPR000261
Domain	EHD1/EHD3	EHD3 EHD1	3.01e-05	2	103	2	IPR029951
Domain	-	SAAL1 CAND1 ARMC3 HEATR4 PSMD1 NF1 ASPM TANGO6	3.17e-05	222	103	8	1.25.10.10
Domain	G_DYNAMIN_dom	EHD3 EHD2 EHD1	5.67e-05	14	103	3	IPR030381
Domain	G_DYNAMIN_2	EHD3 EHD2 EHD1	5.67e-05	14	103	3	PS51718
Domain	P-loop_NTPase	MYH1 DLG5 MYH7 MYH13 MYO5B DDX60 ATL3 DHX33 EHD3 EHD2 MDN1 UCKL1 EHD1 ASPM MYH15	6.20e-05	848	103	15	IPR027417
Domain	Dynamin_GTPase	EHD3 EHD2 EHD1	7.06e-05	15	103	3	IPR001401
Domain	Dynamin_SF	EHD3 EHD2 EHD1	7.06e-05	15	103	3	IPR022812
Domain	Dynamin_N	EHD3 EHD2 EHD1	7.06e-05	15	103	3	PF00350
Domain	ARM-type_fold	SAAL1 CAND1 ARMC3 HEATR4 PSMD1 VIRMA NF1 ASPM TANGO6	1.08e-04	339	103	9	IPR016024
Domain	ARM-like	SAAL1 CAND1 ARMC3 HEATR4 PSMD1 NF1 ASPM TANGO6	1.25e-04	270	103	8	IPR011989
Domain	LRRNT	LGR5 BGN AMIGO3 FLRT2	2.08e-04	53	103	4	PF01462
Domain	Spectrin	TRIO SYNE1 DMD	2.66e-04	23	103	3	PF00435
Domain	PUG	RNASEL NGLY1	2.98e-04	5	103	2	SM00580
Domain	DH_1	RASGRF1 TRIO PLEKHG3 ARHGEF1	4.05e-04	63	103	4	PS00741
Domain	EF_Hand_1_Ca_BS	EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1	4.19e-04	175	103	6	IPR018247
Domain	PUB_domain	RNASEL NGLY1	4.45e-04	6	103	2	IPR018997
Domain	Spectrin_repeat	TRIO SYNE1 DMD	5.36e-04	29	103	3	IPR002017
Domain	RhoGEF	RASGRF1 TRIO PLEKHG3 ARHGEF1	5.42e-04	68	103	4	SM00325
Domain	RhoGEF	RASGRF1 TRIO PLEKHG3 ARHGEF1	6.05e-04	70	103	4	PF00621
Domain	DH_2	RASGRF1 TRIO PLEKHG3 ARHGEF1	6.05e-04	70	103	4	PS50010
Domain	-	EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1 DMD	6.08e-04	261	103	7	1.10.238.10
Domain	-	RASGRF1 TRIO PLEKHG3 ARHGEF1	6.38e-04	71	103	4	1.20.900.10
Domain	DH-domain	RASGRF1 TRIO PLEKHG3 ARHGEF1	6.38e-04	71	103	4	IPR000219
Domain	SPEC	TRIO SYNE1 DMD	7.19e-04	32	103	3	SM00150
Domain	Spectrin/alpha-actinin	TRIO SYNE1 DMD	7.19e-04	32	103	3	IPR018159
Domain	EF_HAND_1	EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1	9.37e-04	204	103	6	PS00018
Domain	EF-hand-dom_pair	EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1 DMD	1.06e-03	287	103	7	IPR011992
Domain	GDS_CDC24_CS	RASGRF1 TRIO ARHGEF1	1.29e-03	39	103	3	IPR001331
Domain	EF_HAND_2	EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1	1.77e-03	231	103	6	PS50222
Domain	EF_hand_dom	EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1	1.81e-03	232	103	6	IPR002048
Domain	LRRNT	LGR5 BGN AMIGO3 FLRT2	2.12e-03	98	103	4	IPR000372
Domain	LRRNT	LGR5 BGN AMIGO3 FLRT2	2.12e-03	98	103	4	SM00013
Domain	PP2Ac	PPEF1 PPP4C	2.26e-03	13	103	2	SM00156
Domain	Ser/Thr-sp_prot-phosphatase	PPEF1 PPP4C	2.26e-03	13	103	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPEF1 PPP4C	2.26e-03	13	103	2	PS00125
Domain	Ras_G-nucl-exch_fac_CS	RASGRF1 RAPGEF3	2.62e-03	14	103	2	IPR019804
Domain	RasGEFN	RASGRF1 RAPGEF3	5.36e-03	20	103	2	SM00229
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH1 MYH7 MYH13 MYH15 DMD	3.23e-05	70	74	5	M12294
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	STARD13 ZC3HC1 XPNPEP1 DHX33 HRNR DCTN1 VIRMA OPTN NF1 MDN1 ARHGEF1 EHD1 ASPM USP4 TNFAIP1 PRKCZ IFT80 PPP1R42 RPAP2	4.70e-09	1242	104	19	30973865
Pubmed	C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?	EHD3 EHD2 EHD1	1.04e-07	4	104	3	16155252
Pubmed	Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.	EHD3 EHD2 EHD1	1.04e-07	4	104	3	15020713
Pubmed	Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.	EHD3 EHD2 EHD1	1.04e-07	4	104	3	17233914
Pubmed	EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.	EHD3 EHD2 EHD1	1.04e-07	4	104	3	10673336
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CAND1 TRIO MYO5B SYNE1 ZC3HC1 DCTN1 VIRMA RUFY3 EHD3 NF1 SACS ARHGEF1 MCU EHD1 ERC2 USP4 DMD TNNT2	2.37e-07	1431	104	18	37142655
Pubmed	EH domain proteins regulate cardiac membrane protein targeting.	EHD3 EHD2 EHD1	2.59e-07	5	104	3	20489164
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYH13 DDX60 SYNE1 HRNR VIRMA MDN1 ASPM DMD	5.51e-07	234	104	8	36243803
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH7 MYH13	9.01e-07	7	104	3	35210422
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STARD13 MYH1 MYH7 MYH13 ARMC3 MYO5B SYNE1 PSMD1 DCTN1 UBLCP1 MDN1 SACS ASPM ERC2 MYH15 NGLY1 DMD	1.30e-06	1442	104	17	35575683
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CAND1 ZC3HC1 PSMD1 DCTN1 ORC2 NF1 MDN1 ARHGEF1 EHD1 BUB1B CPSF1	1.44e-06	582	104	11	20467437
Pubmed	Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.	MYO5B EHD3 EHD1	1.44e-06	8	104	3	17507647
Pubmed	The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.	EHD3 EHD2 EHD1	4.21e-06	11	104	3	26455409
Pubmed	Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene.	MYH7 TNNT2	8.86e-06	2	104	2	15769782
Pubmed	Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice.	BGN DMD	8.86e-06	2	104	2	21187385
Pubmed	Troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy.	MYH7 TNNT2	8.86e-06	2	104	2	18029407
Pubmed	SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.	EHD3 EHD1	8.86e-06	2	104	2	26226295
Pubmed	Long-term follow-up of R403WMYH7 and R92WTNNT2 HCM families: mutations determine left ventricular dimensions but not wall thickness during disease progression.	MYH7 TNNT2	8.86e-06	2	104	2	17612745
Pubmed	PKC zeta controls DNA topoisomerase-dependent human caspase-2 pre-mRNA splicing.	CASP2 PRKCZ	8.86e-06	2	104	2	18166155
Pubmed	Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.	MYH1 MYH7	8.86e-06	2	104	2	2421254
Pubmed	Digenic inheritance of mutations in the cardiac troponin (TNNT2) and cardiac beta myosin heavy chain (MYH7) as the cause of severe dilated cardiomyopathy.	MYH7 TNNT2	8.86e-06	2	104	2	28642161
Pubmed	Mutation rates in the dystrophin gene: a hotspot of mutation at a CpG dinucleotide.	F9 DMD	8.86e-06	2	104	2	15643612
Pubmed	A Variant Detection Pipeline for Inherited Cardiomyopathy-Associated Genes Using Next-Generation Sequencing.	MYH7 TNNT2	8.86e-06	2	104	2	25937619
Pubmed	Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy.	MYH7 TNNT2	8.86e-06	2	104	2	11106718
Pubmed	Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.	MYH1 MYH7	8.86e-06	2	104	2	35759444
Pubmed	Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system.	MYH7 TNNT2	8.86e-06	2	104	2	27082122
Pubmed	Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin.	RASGRF1 NF1	8.86e-06	2	104	2	30337665
Pubmed	Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss.	DDR2 NF1	8.86e-06	2	104	2	24296828
Pubmed	Abnormal blood pressure response to exercise occurs more frequently in hypertrophic cardiomyopathy patients with the R92W troponin T mutation than in those with myosin mutations.	MYH7 TNNT2	8.86e-06	2	104	2	19880069
Pubmed	Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: a comprehensive outpatient perspective.	MYH7 TNNT2	8.86e-06	2	104	2	12084606
Pubmed	Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.	MYH1 MYH7 DMD	9.23e-06	14	104	3	28153048
Pubmed	Endothelial Cyp26b1 restrains murine heart valve growth during development.	ADAM15 BGN EHD3 EHD2 FLRT2 TNNT2	1.00e-05	163	104	6	35364055
Pubmed	Essential role of MESP1-RING1A complex in cardiac differentiation.	MYH7 PHC1 TNNT2	1.15e-05	15	104	3	36413948
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 CAND1 GNE ATL3 PSMD1 DHX33 ANKHD1 DCTN1 NF1 MDN1 PLEKHG3 ARHGEF1 EHD1 ASPM CPSF1	1.21e-05	1353	104	15	29467282
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MYH1 MYH7 MYH13 TRIO DDR2 RB1CC1 DCTN1 CCNT2 OPTN NF1 BUB1B MYH15	1.83e-05	910	104	12	36736316
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	CAND1 VPS39 DDX60 ANKHD1 DCTN1 CLCC1 RUFY3	2.49e-05	285	104	7	32838362
Pubmed	Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ.	LGR5 PRKCZ	2.65e-05	3	104	2	25660024
Pubmed	Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy.	MYH7 TNNT2	2.65e-05	3	104	2	12473556
Pubmed	Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion.	EHD2 EHD1	2.65e-05	3	104	2	21177873
Pubmed	Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.	EHD3 EHD1	2.65e-05	3	104	2	25686250
Pubmed	Mutation spectrum in a large cohort of unrelated Chinese patients with hypertrophic cardiomyopathy.	MYH7 TNNT2	2.65e-05	3	104	2	23711808
Pubmed	Mutations profile in Chinese patients with hypertrophic cardiomyopathy.	MYH7 TNNT2	2.65e-05	3	104	2	15563892
Pubmed	The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.	MYH1 MYH7	2.65e-05	3	104	2	21470888
Pubmed	A Next-Generation Sequencing Approach to Identify Gene Mutations in Early- and Late-Onset Hypertrophic Cardiomyopathy Patients of an Italian Cohort.	MYH7 TNNT2	2.65e-05	3	104	2	27483260
Pubmed	Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter.	DMD TNNT2	2.65e-05	3	104	2	31857666
Pubmed	Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy.	MYH7 TNNT2	2.65e-05	3	104	2	33588347
Pubmed	Structural and developmental analysis of two linked myosin heavy chain genes.	MYH1 MYH7	2.65e-05	3	104	2	1371481
Pubmed	EHD Proteins Cooperate to Generate Caveolar Clusters and to Maintain Caveolae during Repeated Mechanical Stress.	EHD2 EHD1	2.65e-05	3	104	2	28943089
Pubmed	Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.	EHD3 EHD1	2.65e-05	3	104	2	24019528
Pubmed	Dextrocardia and symmetric hypertrophic cardiomyopathy with multiple mutations of genes encoding the sarcomere proteins.	MYH7 TNNT2	2.65e-05	3	104	2	25863306
Pubmed	Prevalence and Phenotypic Expression of Mutations in the MYH7, MYBPC3 and TNNT2 Genes in Families with Hypertrophic Cardiomyopathy in the South of Brazil: A Cross-Sectional Study.	MYH7 TNNT2	2.65e-05	3	104	2	27737317
Pubmed	Screening of MYH7, MYBPC3, and TNNT2 genes in Brazilian patients with hypertrophic cardiomyopathy.	MYH7 TNNT2	2.65e-05	3	104	2	24093860
Pubmed	Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.	LGR5 PRKCZ	2.65e-05	3	104	2	25655195
Pubmed	EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.	EHD3 EHD1	2.65e-05	3	104	2	12121420
Pubmed	Mutations in sarcomere protein genes in left ventricular noncompaction.	MYH7 TNNT2	2.65e-05	3	104	2	18506004
Pubmed	[Study of mutations causing hypertrophic cardiomyopathy in a group of patients from Espirito Santo, Brazil].	MYH7 TNNT2	2.65e-05	3	104	2	20414521
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	MYH7 SYNE1 PSMD1 DCTN1	3.23e-05	60	104	4	20682791
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	MYH7 SYNE1 ANKHD1	3.84e-05	22	104	3	12812986
Pubmed	The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.	LGR5 PRKCZ	5.29e-05	4	104	2	29694894
Pubmed	Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.	EHD3 EHD1	5.29e-05	4	104	2	16251358
Pubmed	Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150(Glued) stops dynein-dependent membrane motility.	CASP2 DCTN1	5.29e-05	4	104	2	11425872
Pubmed	EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.	EHD3 EHD1	5.29e-05	4	104	2	27189942
Pubmed	Identification of pathogenic variants in genes related to channelopathy and cardiomyopathy in Korean sudden cardiac arrest survivors.	MYH7 TNNT2	5.29e-05	4	104	2	28202948
Pubmed	Impact of QT variables on clinical outcome of genotyped hypertrophic cardiomyopathy.	MYH7 TNNT2	5.29e-05	4	104	2	19149795
Pubmed	Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.	EHD3 EHD1	5.29e-05	4	104	2	29212907
Pubmed	Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy.	MYH7 TNNT2	5.29e-05	4	104	2	20624503
Pubmed	Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.	LGR5 PRKCZ	5.29e-05	4	104	2	38815584
Pubmed	Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.	MYH7 MYH15	5.29e-05	4	104	2	19948655
Pubmed	MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.	MCU DMD	5.29e-05	4	104	2	38514795
Pubmed	Targeted next-generation sequencing (NGS) of nine candidate genes with custom AmpliSeq in patients and a cardiomyopathy risk group.	MYH7 TNNT2	5.29e-05	4	104	2	25892673
Pubmed	In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1.	LGR5 HES5	5.29e-05	4	104	2	26224861
Pubmed	EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.	EHD2 EHD1	5.29e-05	4	104	2	15930129
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH13	5.29e-05	4	104	2	10388558
Pubmed	Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development.	MYH1 DMD	5.29e-05	4	104	2	28569755
Pubmed	Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation.	NF1 PRKCZ	5.29e-05	4	104	2	25070947
Pubmed	Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice.	MYH7 DMD	5.29e-05	4	104	2	25139234
Pubmed	Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.	LGR5 PRKCZ	5.29e-05	4	104	2	30552022
Pubmed	Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy.	MYH7 TNNT2	5.29e-05	4	104	2	20800588
Pubmed	SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.	MYH1 MYH7 TNNT2	6.42e-05	26	104	3	26586428
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	SAAL1 TRIO MYO5B PSMD1 RB1CC1 PPEF1 UBLCP1 CLCC1 PTPN5 PPP4C CPSF1 DMD	7.20e-05	1049	104	12	27880917
Pubmed	Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.	EHD3 EHD2 EHD1	8.06e-05	28	104	3	26884322
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	VPS39 USP6 NF1 USP4 IFT80	8.28e-05	147	104	5	29576527
Pubmed	EMRE is essential for mitochondrial calcium uniporter activity in a mouse model.	MCU DMD	8.80e-05	5	104	2	32017711
Pubmed	Mapping of FMR1, the gene implicated in fragile X-linked mental retardation, on the mouse X chromosome.	F9 DMD	8.80e-05	5	104	2	1572655
Pubmed	Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.	LGR5 HES5	8.80e-05	5	104	2	24496619
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH7	8.80e-05	5	104	2	12919077
Pubmed	The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis.	USP6 USP4	8.80e-05	5	104	2	31748695
Pubmed	Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice.	MYH1 TNNT2	8.80e-05	5	104	2	29653945
Pubmed	Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy.	MYH7 TNNT2	8.80e-05	5	104	2	12974739
Pubmed	Somatic MYH7, MYBPC3, TPM1, TNNT2 and TNNI3 mutations in sporadic hypertrophic cardiomyopathy.	MYH7 TNNT2	8.80e-05	5	104	2	23782526
Pubmed	Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi.	EHD2 EHD1	8.80e-05	5	104	2	21115825
Pubmed	[Mutations in sarcomeric genes MYH7, MYBPC3, TNNT2, TNNI3, and TPM1 in patients with hypertrophic cardiomyopathy].	MYH7 TNNT2	8.80e-05	5	104	2	19150014
Pubmed	Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse.	NF1 TNFAIP1	8.80e-05	5	104	2	9804998
Pubmed	Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice.	MYH1 MYH7	8.80e-05	5	104	2	17584907
Pubmed	HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis.	MYH7 PRKCZ TNNT2	8.97e-05	29	104	3	31201155
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	TRIO SYNE1 XPNPEP1 DCTN1 DMD	9.39e-05	151	104	5	17043677
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH7 TNNT2	1.10e-04	31	104	3	21985497
Pubmed	Dilated Cardiomyopathy Overview	MYH7 DMD TNNT2	1.21e-04	32	104	3	20301486
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH7	1.32e-04	6	104	2	1728586
Pubmed	Common susceptibility variants examined for association with dilated cardiomyopathy.	MYH7 TNNT2	1.32e-04	6	104	2	20201937
Interaction	RHOA interactions	DLG5 RASGRF1 TRIO ATL3 PSMD1 XPNPEP1 VIRMA CLCC1 SLC4A2 EHD2 OPTN NF1 MDN1 PLEKHG3 ARHGEF1 MCU TNFAIP1 PRKCZ FLRT2	9.29e-06	1199	103	19	int:RHOA
Interaction	EPN3 interactions	VPS39 CASP2 EHD2 EHD1 TNFAIP1	9.82e-06	56	103	5	int:EPN3
Interaction	MYL2 interactions	MYH1 MYO5B USP6 ASPM	1.82e-05	31	103	4	int:MYL2
Interaction	RBSN interactions	MYH1 MYH7 EHD3 EHD2 EHD1	2.05e-05	65	103	5	int:RBSN
Interaction	KCTD13 interactions	CAND1 TRIO MYO5B SYNE1 ZC3HC1 DCTN1 VIRMA RUFY3 EHD3 NF1 SACS ARHGEF1 MCU EHD1 ERC2 USP4 TNFAIP1 GFPT2 DMD TNNT2	2.23e-05	1394	103	20	int:KCTD13
Interaction	RSPH6A interactions	MYH1 MYH7 MYH13 ASPM	2.65e-05	34	103	4	int:RSPH6A
Interaction	CDC5L interactions	CAND1 USB1 TRIO SYNE1 TRIM31 ZC3HC1 PSMD1 VIRMA ORC2 NF1 PPP4C MDN1 ARHGEF1 EHD1 BUB1B	2.88e-05	855	103	15	int:CDC5L
Interaction	SLC39A3 interactions	MYH1 MYH7 CAND1 MAN2A1 PLEKHG3	2.94e-05	70	103	5	int:SLC39A3
Interaction	ILVBL interactions	SAAL1 RB1CC1 PPEF1 VIRMA TBC1D32 OPTN MDN1	4.32e-05	183	103	7	int:ILVBL
Interaction	RPN2 interactions	GNE SYNE1 DDR2 TRIM31 RB1CC1 PPEF1 DCTN1 VIRMA CLCC1 SLC4A2 EHD3 PTPN5 ARHGEF1 PRKCZ	4.38e-05	782	103	14	int:RPN2
Interaction	EHD4 interactions	RASGRF1 ZC3HC1 RB1CC1 EHD3 EHD2 EHD1	5.04e-05	128	103	6	int:EHD4
Interaction	SCP2D1 interactions	EHD3 EHD1	7.73e-05	3	103	2	int:SCP2D1
GeneFamily	Myosin heavy chains	MYH1 MYH7 MYH13 MYH15	3.05e-07	15	72	4	1098
GeneFamily	EF-hand domain containing	LETM2 EFCAB6 HRNR PPEF1 EHD3 EHD2 EHD1	2.63e-05	219	72	7	863
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 TRIO PLEKHG3 ARHGEF1	1.38e-04	66	72	4	722
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPEF1 PPP4C	1.19e-03	13	72	2	693
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	STARD13 CAND1 MAN2A1 TRIO GNE DDR2 RB1CC1 ORC2 USP6 MDN1 SACS ARNT2 BUB1B FLRT2 DMD	1.45e-06	856	104	15	M4500
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ARMC3 SYNE1 FHAD1 CFAP54 DMD PPP1R42	3.58e-07	193	104	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN CFAP54 RAPGEF3 ARNT2 TNNT2	4.27e-06	181	104	6	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN CFAP54 RAPGEF3 ARNT2 TNNT2	4.27e-06	181	104	6	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARMC3 SYNE1 CFAP54 RAPGEF3 ARNT2 TNNT2	4.84e-06	185	104	6	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARMC3 SYNE1 CFAP54 RAPGEF3 ARNT2 TNNT2	4.84e-06	185	104	6	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH13 DDR2 PTGIS BGN QPRT GFPT2	5.99e-06	192	104	6	859a32c9e4ed6961897b2ccaecde73a599471df9
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH13 DDR2 PTGIS BGN QPRT GFPT2	5.99e-06	192	104	6	89e1da82fa2069dac7adb9cba3e8b6c0179e0dc5
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	MYH13 DDR2 PTGIS BGN FLRT2 GFPT2	6.35e-06	194	104	6	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SYNE1 DDR2 BGN C1QL1 QPRT DMD	7.35e-06	199	104	6	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SYNE1 DDR2 BGN C1QL1 QPRT DMD	7.56e-06	200	104	6	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	SYNE1 DDR2 BGN C1QL1 QPRT DMD	7.56e-06	200	104	6	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STARD13 MYH1 KLHL1 MYH13 IFIT2	2.23e-05	144	104	5	71107275767a0728541a3695715c44874b3e5efc
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EFCAB6 NPHP4 FHAD1 CFAP54 PPP1R42	2.99e-05	153	104	5	fc0d2d50aa3b6b2772bbf3626c9df5c5e8d7d11e
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EFCAB6 NPHP4 FHAD1 CFAP54 PPP1R42	2.99e-05	153	104	5	2482247d9c39c7b99bb45fb9153442f64fd6012f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN SACS RAPGEF3 TNNT2	3.28e-05	156	104	5	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN SACS RAPGEF3 TNNT2	3.28e-05	156	104	5	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	Leuk-UTI-Lymphocyte-T_NK-gdT\|Leuk-UTI / Disease, Lineage and Cell Type	DLG5 SYNE1 BTBD17 OPTN HES5	3.48e-05	158	104	5	c4b0af25608cee3d0d2b0193f5ff45d9dc87078b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STARD13 MYH1 KLHL1 MYH13 IFIT2	4.94e-05	170	104	5	8ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCell	T_cells-GNLY+GZMB+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SYNE1 IFIT2 BFSP1 FHAD1 PLEKHG3	5.08e-05	171	104	5	04c811817cfec45af5f2891793106cc7ddb0300e
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	SYNE1 CFAP54 SACS ARNT2 TNNT2	5.22e-05	172	104	5	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPHP4 PTGIS PLEKHG3 ARNT2 TNNT2	5.98e-05	177	104	5	4553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	SYNE1 DDR2 PTGIS BGN GFPT2	6.14e-05	178	104	5	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 DDR2 PTGIS BGN GFPT2	6.30e-05	179	104	5	6f51a4580c06fc55cc764052c9b26f7c55660282
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ARMC3 SYNE1 CFAP54 ARNT2 TNNT2	6.30e-05	179	104	5	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 DDR2 PTGIS BGN GFPT2	6.30e-05	179	104	5	f14440f6ce9b4fcdd4bcb2488b949f9a0e17bc23
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN2A1 PTGIS BFSP1 SACS FLRT2	6.30e-05	179	104	5	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 DDR2 PTGIS BGN GFPT2	6.30e-05	179	104	5	a6ce1fa338d4905bd6afef00763ac83e916a0b37
ToppCell	Pericytes-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DDR2 BGN EHD3 C1QL1 TMEM179	6.64e-05	181	104	5	35c470988a93381eefa300831aabb813fa1b90bd
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EFCAB6 ARMC3 FHAD1 CFAP54 PPP1R42	6.64e-05	181	104	5	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	EFCAB6 ARMC3 FHAD1 CFAP54 PPP1R42	6.82e-05	182	104	5	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KLHL1 MAN2A1 PPEF1 DMD TNNT2	6.82e-05	182	104	5	205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCell	18-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	ARMC3 MYO5B ADAM15 CFAP54 PPP1R42	7.00e-05	183	104	5	a75cda2131755931117c387f2e0ae3394efa8e80
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTGIS F9 BGN PLEKHG3 TNNT2	7.00e-05	183	104	5	b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EFCAB6 ARMC3 FHAD1 CFAP54 PPP1R42	7.37e-05	185	104	5	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	DDR2 PTGIS BGN FLRT2 GFPT2	7.37e-05	185	104	5	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHP4 LGR5 EHD2 BUB1B ASPM	7.56e-05	186	104	5	3993f1ef8a33b8a75dfd3db8d4845b5afbb0bb3d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHP4 LGR5 EHD2 BUB1B ASPM	7.56e-05	186	104	5	ec6d0c29e196e374baa96dd3d506f489c959e77e
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	7.75e-05	187	104	5	7beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 RAPGEF3 PLEKHG3 ARNT2 TNNT2	7.95e-05	188	104	5	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 RAPGEF3 PLEKHG3 ARNT2 TNNT2	7.95e-05	188	104	5	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN2A1 PTGIS BGN GFPT2 TNNT2	8.15e-05	189	104	5	562f8bf5a7d38afb4a8f2415d617d5f79cfb7e3f
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.15e-05	189	104	5	6b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.15e-05	189	104	5	344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN2A1 PTGIS BGN GFPT2 TNNT2	8.15e-05	189	104	5	270dd4a0fc5260288fe6829837942c78b40ecec4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 DDR2 MDN1 GFPT2 DMD	8.35e-05	190	104	5	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	8.35e-05	190	104	5	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	8.35e-05	190	104	5	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 DDR2 MDN1 GFPT2 DMD	8.35e-05	190	104	5	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR2 PTGIS C1QL1 FLRT2 GFPT2	8.35e-05	190	104	5	f39ce1678fc375eb2a3af781ddb772b0f12c5744
ToppCell	facs-GAT-Fat-24m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN2A1 DDR2 PTGIS BGN GFPT2	8.35e-05	190	104	5	3720e64129f3f3268b1dc14031a76f41c38241c2
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN2A1 DDR2 PTGIS BGN GFPT2	8.35e-05	190	104	5	73a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN2A1 DDR2 PTGIS BGN GFPT2	8.35e-05	190	104	5	b55cf1fb586b724295b7b038483249847bb344fc
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.77e-05	192	104	5	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 EHD2 RAPGEF3 EHD1 TNFAIP1	8.77e-05	192	104	5	24d28e28a5c54ca7770f7e5ad7f4d00039e0aaf9
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	8.77e-05	192	104	5	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.77e-05	192	104	5	d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR2 PTGIS BGN FLRT2 GFPT2	8.77e-05	192	104	5	32acd89617934016cd135d2cc797e8e79ae1b37f
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.77e-05	192	104	5	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR2 PTGIS BGN FLRT2 GFPT2	8.99e-05	193	104	5	9d0b966d13cbce97beb43de6dc77f006c363a181
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.99e-05	193	104	5	80380358f44c2f4781676ec0f1fa94d4c69080d6
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	8.99e-05	193	104	5	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TRPA1 DDR2 PTGIS BGN DMD	8.99e-05	193	104	5	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR2 PTGIS BGN FLRT2 GFPT2	8.99e-05	193	104	5	e27885a9e1a2a3e165c5366d4cfcda05c5454483
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	8.99e-05	193	104	5	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR2 PTGIS C1QL1 FLRT2 GFPT2	9.21e-05	194	104	5	c578cf7c6b4d6f31f87dde8845de5b3891f16822
ToppCell	facs-MAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN EHD2 GFPT2	9.21e-05	194	104	5	f906b090f67df4cfe3498cdbb52cc0efa08e06cc
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR2 PTGIS BGN FLRT2 GFPT2	9.21e-05	194	104	5	c9e589fe7df6a9b377654581a2aebb607cbb03b9
ToppCell	facs-MAT-Fat-18m-Mesenchymal\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN EHD2 GFPT2	9.21e-05	194	104	5	944cdb0403d80a10a2eea2a3516a9343dbccc32c
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	9.21e-05	194	104	5	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR2 PTGIS C1QL1 FLRT2 GFPT2	9.21e-05	194	104	5	f4286ae7bb8350c42d50727ee8688b80129714f6
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	9.21e-05	194	104	5	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR2 PTGIS C1QL1 FLRT2 GFPT2	9.21e-05	194	104	5	87461bd6d7f702c0a0f5e0c8ace3049125a51f9a
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR2 PTGIS C1QL1 FLRT2 GFPT2	9.21e-05	194	104	5	421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MYO5B CFAP54 ERC2 PRKCZ DMD	9.21e-05	194	104	5	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFCAB6 ARMC3 SYNE1 FHAD1 CFAP54	9.21e-05	194	104	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	facs-MAT-Fat-18m-Mesenchymal-mesenchymal_progenitor\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN EHD2 GFPT2	9.21e-05	194	104	5	85081d255fcc1e9854c0073321dd9f0feaa48866
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN C1QL1 RAPGEF3 TNNT2	9.21e-05	194	104	5	1374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR2 PTGIS BGN FLRT2 GFPT2	9.44e-05	195	104	5	0866aaf053762d1a021fcbccff058526078a99da
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTGIS BGN PLEKHG3 DMD TNNT2	9.44e-05	195	104	5	c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DDR2 PTGIS BGN FLRT2 DMD	9.44e-05	195	104	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTGIS BGN PLEKHG3 DMD TNNT2	9.44e-05	195	104	5	43d372373367b71243c6ea958aedccde4478618f
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	9.44e-05	195	104	5	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN C1QL1 RAPGEF3 TNNT2	9.67e-05	196	104	5	34e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN C1QL1 RAPGEF3 TNNT2	9.67e-05	196	104	5	8f82e01ca50aa4cd6149547505b4474a02fad618
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	DDR2 BGN BUB1B ASPM GFPT2	9.67e-05	196	104	5	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN C1QL1 RAPGEF3 TNNT2	9.67e-05	196	104	5	023477a499a2c190f363cfdbc9d9c646733a6541
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	EFCAB6 TRIO ADAM15 KCNH6 MCU	9.67e-05	196	104	5	7be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN C1QL1 RAPGEF3 TNNT2	9.67e-05	196	104	5	3cb74f1a333a82cac2b459f2f1517e2acf22b5fd
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRIO DDR2 PTGIS FLRT2 GFPT2	9.67e-05	196	104	5	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	9.67e-05	196	104	5	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	9.90e-05	197	104	5	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFCAB6 SYNE1 FHAD1 CFAP54 DMD	9.90e-05	197	104	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM15 PTGIS C1QL1 BUB1B ASPM	9.90e-05	197	104	5	76b61e60a757e58b465569538e632d6d9953e89a
ToppCell	droplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 PTGIS BGN FLRT2 GFPT2	1.01e-04	198	104	5	d4f74320ea6c1a7e568ee5bc48bb66cb45e1004d
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARMC3 SYNE1 FHAD1 CFAP54 PPP1R42	1.01e-04	198	104	5	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 MDN1 FLRT2 GFPT2 DMD	1.01e-04	198	104	5	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	STARD13 TRIO NF1 MCU DMD	1.01e-04	198	104	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	DDR2 BGN EHD2 FLRT2 GFPT2	1.01e-04	198	104	5	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	356C-Fibroblasts-Fibroblast-F\|356C / Donor, Lineage, Cell class and subclass (all cells)	DDR2 PTGIS BGN FLRT2 GFPT2	1.04e-04	199	104	5	59fe5f3c6338e019a149ab135acf9cc5657298bf
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 BGN C1QL1 RAPGEF3 TNNT2	1.04e-04	199	104	5	b9338b739162cd8e5661c9a4dcb41a31219b5723
Drug	fast white	MYH1 MYH7 MYH13 MYO5B TNNT2	1.34e-06	42	104	5	CID000024008
Drug	AC1NRBPQ	MYH1 MYH7 MYH13 MYO5B CASP2 TNNT2 THAP12	3.20e-06	137	104	7	CID005288569
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.89e-08	10	103	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	6.78e-08	12	103	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	6.78e-08	12	103	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	9.77e-08	13	103	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	1.86e-07	15	103	4	DOID:0050646 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MCU MYH15 TNNT2	1.86e-07	71	103	6	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15 DMD	9.18e-06	80	103	5	DOID:12930 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH7 MYH13 MYH15	2.42e-05	48	103	4	DOID:423 (implicated_via_orthology)
Disease	Distal Muscular Dystrophies	MYH7 GNE	1.20e-04	5	103	2	C0751336
Disease	Idiopathic hypertrophic subaortic stenosis	MYH7 TNNT2	2.51e-04	7	103	2	C0700053
Disease	Obstructive asymmetric septal hypertrophy	MYH7 TNNT2	2.51e-04	7	103	2	C0597124
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	MYH7 SYNE1	2.51e-04	7	103	2	C0751337
Disease	Meckel syndrome (implicated_via_orthology)	NPHP4 TBC1D32	3.33e-04	8	103	2	DOID:0050778 (implicated_via_orthology)
Disease	Embryonal Rhabdomyosarcoma	BUB1B DMD	3.33e-04	8	103	2	C0206656
Disease	Cardiomyopathy, Hypertrophic, Familial	MYH7 TNNT2	4.28e-04	9	103	2	C0949658
Disease	dilated cardiomyopathy (is_implicated_in)	MYH7 DMD TNNT2	4.61e-04	43	103	3	DOID:12930 (is_implicated_in)
Disease	Familial dilated cardiomyopathy	MYH7 DMD TNNT2	4.93e-04	44	103	3	C0340427
Disease	Cardiomyopathy, Dilated	MYH7 DMD TNNT2	6.37e-04	48	103	3	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	MYH7 DMD TNNT2	7.19e-04	50	103	3	C1449563
Disease	Left ventricular noncompaction	MYH7 TNNT2	1.07e-03	14	103	2	C1960469
Disease	Germ Cell Cancer	PHC1 BUB1B	1.23e-03	15	103	2	C0740345
Disease	Germ cell tumor	PHC1 BUB1B	1.23e-03	15	103	2	C0205851
Disease	Neoplasms, Embryonal and Mixed	PHC1 BUB1B	1.23e-03	15	103	2	C0205852
Disease	Embryonal Neoplasm	PHC1 BUB1B	1.23e-03	15	103	2	C0027654
Disease	Neoplasms, Germ Cell and Embryonal	PHC1 BUB1B	1.23e-03	15	103	2	C0027658
Disease	Cancer, Embryonal	PHC1 BUB1B	1.23e-03	15	103	2	C0751364
Disease	Cancer, Embryonal and Mixed	PHC1 BUB1B	1.23e-03	15	103	2	C0751365
Disease	Autosomal recessive primary microcephaly	PHC1 ASPM	1.23e-03	15	103	2	cv:C3711387
Disease	bipolar I disorder	SYNE1 XPNPEP1 ANKHD1 TMEM179	1.53e-03	141	103	4	EFO_0009963
Disease	Amyotrophic lateral sclerosis	DCTN1 OPTN	1.59e-03	17	103	2	cv:C0002736
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	MYH13 DDR2 ERC2	1.99e-03	71	103	3	EFO_0004735, EFO_0007965
Disease	temporal lobe epilepsy (is_marker_for)	RASGRF1 CASP2	2.20e-03	20	103	2	DOID:3328 (is_marker_for)
Disease	Myopia	KLHL1 RASGRF1 MYO5B BTBD17 PTPN5 ERC2	2.35e-03	385	103	6	HP_0000545
Disease	Primary microcephaly	PHC1 ASPM	2.66e-03	22	103	2	C0431350
Disease	hypertrophic cardiomyopathy (is_implicated_in)	MYH7 TNNT2	2.66e-03	22	103	2	DOID:11984 (is_implicated_in)
Disease	Autosomal Recessive Primary Microcephaly	PHC1 ASPM	2.66e-03	22	103	2	C3711387
Disease	Primary familial hypertrophic cardiomyopathy	MYH7 TNNT2	2.66e-03	22	103	2	cv:C0949658
Disease	Cardiac Hypertrophy	PRKCZ DMD TNNT2	3.00e-03	82	103	3	C1383860
Disease	Cardiomegaly	PRKCZ DMD TNNT2	3.00e-03	82	103	3	C0018800
Disease	congenital heart disease (is_implicated_in)	MYH7 NPHP4	3.17e-03	24	103	2	DOID:1682 (is_implicated_in)
Disease	Colorectal Carcinoma	SYNE1 LGR5 NF1 SACS ARHGEF1 BUB1B PRKCZ DMD	3.23e-03	702	103	8	C0009402
Disease	Hypertrophic obstructive cardiomyopathy	MYH7 TNNT2	3.44e-03	25	103	2	C4551472

Protein segments in the cluster

Peptide	Gene	Start	Entry
IADLAHLLLFKEHLQ	BUB1B	956	O60566
HEVFVELNELLLDKN	SLC4A2	321	P04920
DKAVEVHVLLLDDLL	ARHGEF1	661	Q92888
EKINEQLALLETHLL	CFAP54	1276	Q96N23
ELLDELTHEFLQILE	CCNT2	231	O60583
ERSLDFLIELLHKDQ	DCTN1	696	Q14203
FLIELLHKDQLDETV	DCTN1	701	Q14203
EALIELLEKFVLHLT	TBC1D32	966	Q96NH3
DDHLLKNIELFDKLS	TNFAIP1	176	Q13829
IKLELDGDSHILELL	ADAM15	71	Q13444
RVDLIILLFDAHKLE	EHD2	181	Q9NZN4
ILLFDAHKLEISDEF	EHD2	186	Q9NZN4
DLVLQDELELFHALE	BTBD17	221	A6NE02
ILHLDAGDEVFIKLD	C1QL1	221	O75973
LETKELNDLHIEALA	ARMC3	241	Q5W041
LEKKLEDLEEQLNHL	DMD	2326	P11532
EKLLLFNNRLVHLDE	AMIGO3	136	Q86WK7
QLLKLEELHLDDNSI	FLRT2	131	O43155
LNLDQLKEEIAFLKH	ASPM	1061	Q8IZT6
SFLTEQELKHLILEA	ARNT2	131	Q9HBZ2
EHIDDKIALLLDLLQ	PAAT	406	Q9H8K7
QAEELHEKALDPFLL	PTPN5	286	P54829
KDLQHRLDEAEQIAL	MYH7	1791	P12883
HVENDEKLQLLRAEL	RB1CC1	966	Q8TDY2
FSKLFEDQLALEHLD	LETM2	276	Q2VYF4
HLAKDFIDKLLILEA	PSKH2	291	Q96QS6
IHLDNLDKRELNEVL	MDN1	471	Q9NU22
IDLLLLDDFKLVIND	MCU	141	Q8NE86
INISDEDFLLLELLH	NGLY1	221	Q96IV0
LQEKIDHLERLLAEN	MAN2A1	51	Q16706
DDLKEFLQIDLHTLH	DDR2	81	Q16832
DLHKIQRADLLEVLD	KCNH6	681	Q9H252
HLSDLNDELLLKNIA	DDX60	371	Q8IY21
FVDLIEHLLSELSKN	CAND1	211	Q86VP6
LDEKLLNIIDLQFLH	CPSF1	196	Q10570
DLLEEAADLLVVHLD	PEX26	36	Q7Z412
LDHNKIQAIELEDLL	BGN	236	P21810
KYNHDIALLELDEPL	F9	311	P00740
AELKELLENEFHQIL	HRNR	31	Q86YZ3
LLKLLLAKERDHFQD	DLG5	56	Q8TDM6
DLQHRLDEAEQLALK	MYH1	1796	P12882
ADLVLLDNFKPEELH	QPRT	216	Q15274
LQAEHDRQAKELFLL	ERC2	266	O15083
SLEKFEEELLELHVQ	NPHP4	251	O75161
HDAFEILVELLQALV	THAP12	431	O43422
ALLNINFDIKHDLDL	THAP12	721	O43422
EHLIDDLLAAQKEIL	FHAD1	991	B1AJZ9
FLSHKNEILEIALDQ	IFT80	456	Q9P2H3
EHLAKIFDEILLQVF	C2orf92	71	A0A1B0GVN3
VLSLEEKIHDLALEL	GFPT2	521	O94808
LQREAKKLHDEDLLL	GNE	596	Q9Y223
LHLLLNLKDDEFERF	EFCAB6	771	Q5THR3
LERLNKEADEALLHN	BFSP1	141	Q12934
LDVLLLENHDAVLKE	HEATR4	836	Q86WZ0
DLLGALEHKDDQLTL	DHX33	476	Q9H6R0
LDEKALASILLQDHI	ATL3	41	Q6DD88
EALHVLAFLQELNEK	IFIT2	431	P09913
ILLFDAHKLDISDEF	EHD1	186	Q9H4M9
LDDEEFALANHLIKV	EHD1	496	Q9H4M9
LTQDDFHLKILKDIL	SAAL1	386	Q96ER3
QLFEKLESLLIIHDA	SACS	3516	Q9NZJ4
LLLSELLEHLLEKDI	CASP2	51	P42575
LLDFEEDLKALHSVQ	LGR5	526	O75473
IDLLLEAFKEQQILH	PPEF1	121	O14829
HDLLLNEKLDREELC	PCDHB6	81	Q9Y5E3
HEEKEQLALQLAVLL	OPTN	486	Q96CV9
KEDSSLELFLLIHNL	ORC2	381	Q13416
QQLDDLRALKHELAF	RUFY3	396	Q7L099
DLEKDDLFPHLDDIL	STARD13	476	Q9Y3M8
ELLHQVLEEEKNFLL	TRIM31	186	Q9BZY9
NLDNHLRAEELLKEF	SYNE1	2226	Q8NF91
LLLQEIAKHFDEEED	PLEKHG3	236	A1L390
FLVLVHLDLELINAD	PTGIS	456	Q16647
NESKILHFQLELLEA	MYH15	1566	Q9Y2K3
LHFQLELLEAKAELE	MYH15	1571	Q9Y2K3
VDNQLLHVKDLEFLL	PPP1R42	176	Q7Z4L9
LLDEDEPQLKEFALH	PSMD1	11	Q99460
DLLKFIRNLGEHIDE	RNASEL	661	Q05823
EIAEQLTLLDHLVFK	RASGRF1	1041	Q13972
ILLFDAHKLDISDEF	EHD3	186	Q9NZN3
LDDDEFALANHLIKV	EHD3	496	Q9NZN3
IEQLKLLLEQEFARH	HES5	36	Q5TA89
DIVKLLLLHDADVNS	ANKHD1	286	Q8IWZ3
LDDALSDILINFKFH	CLCC1	151	Q96S66
EDKISLLLHLLEDEL	ZC3HC1	211	Q86WB0
EELDLIFEELLHIKA	RAPGEF3	231	O95398
ELLAFLLDGLHEDLN	USP4	396	Q13107
LKDLTFLLEKQHELI	TRPA1	1051	O75762
SVKEHLLLDLGLEAE	XPNPEP1	246	Q9NQW7
EEDLEKLIDHQGLYL	ZSCAN20	691	P17040
HSKEEILELLVLEQF	ZSCAN32	71	Q9NX65
LDKGLEHNLDLLRYE	ZNF568	181	Q3ZCX4
QEDLLDSLIHEKELL	TMEM179	201	Q6ZVK1
LHLKNEDLESLTIIF	RPAP2	591	Q8IXW5
LLLNELAKFRSEHEL	SOGA1	301	O94964
EKDLNELQALIEAHF	TNNT2	106	P45379
QEKLLKIFLENLEHE	TANGO6	876	Q9C0B7
AKLHAQLALEELDDI	TANGO6	1061	Q9C0B7
DLQHRLDEAEQLALK	MYH13	1796	Q9UKX3
LALEEDLKVFHNALK	NF1	1731	P21359
EIDGQALLLLKEEHL	PHC1	966	P78364
AKEEFLDLLDVLLPH	USB1	91	Q9BQ65
LKEIAKLDDFLDLNH	UBLCP1	291	Q8WVY7
DHDVPEDKIFLLSLL	UCKL1	471	Q9NWZ5
AILELDEHLQKDFII	PPP4C	271	P60510
DIVHRDLKCENLLLD	TSSK2	131	Q96PF2
NLFLELEKLVLEHSK	VIRMA	1451	Q69YN4
ELLAFLLDGLHEDLN	USP6	626	P35125
LLEFLHEKQQELDLA	TRIO	881	O75962
LKNLLHAEFLRVQEE	VPS39	821	Q96JC1
LADLENHALFKNDLE	KLHL1	411	Q9NR64
DLKLDNVLLDADGHI	PRKCZ	376	Q05513
SLLLNQLKLAHEELE	MYO5B	1241	Q9ULV0