| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | nodal binding | 1.47e-05 | 8 | 15 | 2 | GO:0038100 | |
| GeneOntologyMolecularFunction | activin receptor binding | 4.77e-05 | 14 | 15 | 2 | GO:0070697 | |
| GeneOntologyMolecularFunction | transmembrane receptor protein serine/threonine kinase binding | 1.83e-04 | 27 | 15 | 2 | GO:0070696 | |
| GeneOntologyMolecularFunction | receptor serine/threonine kinase binding | 3.09e-04 | 35 | 15 | 2 | GO:0033612 | |
| GeneOntologyMolecularFunction | protease binding | 7.94e-03 | 181 | 15 | 2 | GO:0002020 | |
| GeneOntologyBiologicalProcess | left lung morphogenesis | 2.96e-06 | 4 | 15 | 2 | GO:0060460 | |
| GeneOntologyBiologicalProcess | left lung development | 4.93e-06 | 5 | 15 | 2 | GO:0060459 | |
| GeneOntologyBiologicalProcess | atrial septum morphogenesis | 7.50e-05 | 18 | 15 | 2 | GO:0060413 | |
| GeneOntologyBiologicalProcess | atrial septum development | 1.47e-04 | 25 | 15 | 2 | GO:0003283 | |
| GeneOntologyBiologicalProcess | nodal signaling pathway | 1.59e-04 | 26 | 15 | 2 | GO:0038092 | |
| GeneOntologyBiologicalProcess | cardiac atrium morphogenesis | 2.90e-04 | 35 | 15 | 2 | GO:0003209 | |
| GeneOntologyBiologicalProcess | cardiac atrium development | 4.18e-04 | 42 | 15 | 2 | GO:0003230 | |
| GeneOntologyBiologicalProcess | spleen development | 6.41e-04 | 52 | 15 | 2 | GO:0048536 | |
| GeneOntologyBiologicalProcess | digestive tract morphogenesis | 8.25e-04 | 59 | 15 | 2 | GO:0048546 | |
| GeneOntologyBiologicalProcess | activin receptor signaling pathway | 8.53e-04 | 60 | 15 | 2 | GO:0032924 | |
| GeneOntologyCellularComponent | Cul4-RING E3 ubiquitin ligase complex | 4.30e-04 | 38 | 17 | 2 | GO:0080008 | |
| GeneOntologyCellularComponent | plasma membrane bounded cell projection cytoplasm | 2.01e-03 | 317 | 17 | 3 | GO:0032838 | |
| GeneOntologyCellularComponent | motile cilium | 2.77e-03 | 355 | 17 | 3 | GO:0031514 | |
| GeneOntologyCellularComponent | cytoplasmic region | 2.88e-03 | 360 | 17 | 3 | GO:0099568 | |
| GeneOntologyCellularComponent | side of membrane | 4.69e-03 | 875 | 17 | 4 | GO:0098552 | |
| MousePheno | total anomalous pulmonary venous connection, intracardiac | 7.98e-07 | 2 | 13 | 2 | MP:0010443 | |
| MousePheno | total anomalous pulmonary venous connection | 4.79e-06 | 4 | 13 | 2 | MP:0010441 | |
| MousePheno | unbalanced complete common atrioventricular canal | 4.79e-06 | 4 | 13 | 2 | MP:0011673 | |
| MousePheno | superior-inferior ventricles | 1.67e-05 | 7 | 13 | 2 | MP:0011254 | |
| MousePheno | accessory spleen | 2.86e-05 | 9 | 13 | 2 | MP:0003342 | |
| MousePheno | abnormal direction of embryo turning | 6.19e-05 | 13 | 13 | 2 | MP:0004190 | |
| MousePheno | d-loop transposition of the great arteries | 6.19e-05 | 13 | 13 | 2 | MP:0011665 | |
| MousePheno | heart right ventricle hypoplasia | 7.22e-05 | 14 | 13 | 2 | MP:0010422 | |
| MousePheno | anomalous pulmonary venous connection | 8.33e-05 | 15 | 13 | 2 | MP:0010440 | |
| MousePheno | abnormal copulatory plug deposition | 9.51e-05 | 16 | 13 | 2 | MP:0030982 | |
| MousePheno | mesocardia | 1.50e-04 | 20 | 13 | 2 | MP:0000650 | |
| MousePheno | abnormal azygos vein morphology | 1.50e-04 | 20 | 13 | 2 | MP:0011569 | |
| MousePheno | common atrium | 2.18e-04 | 24 | 13 | 2 | MP:0010406 | |
| MousePheno | abnormal copulation behavior | 2.18e-04 | 24 | 13 | 2 | MP:0009697 | |
| MousePheno | right pulmonary isomerism | 2.37e-04 | 25 | 13 | 2 | MP:0000531 | |
| MousePheno | decreased heart right ventricle size | 2.37e-04 | 25 | 13 | 2 | MP:0003649 | |
| MousePheno | complete atrioventricular septal defect | 2.56e-04 | 26 | 13 | 2 | MP:0010413 | |
| MousePheno | abnormal left lung morphology | 2.98e-04 | 28 | 13 | 2 | MP:0009569 | |
| MousePheno | absent spleen | 3.20e-04 | 29 | 13 | 2 | MP:0000690 | |
| MousePheno | right-sided isomerism | 3.42e-04 | 30 | 13 | 2 | MP:0000508 | |
| MousePheno | right-sided stomach | 3.66e-04 | 31 | 13 | 2 | MP:0010808 | |
| MousePheno | left-sided isomerism | 4.40e-04 | 34 | 13 | 2 | MP:0000542 | |
| MousePheno | vascular ring | 4.67e-04 | 35 | 13 | 2 | MP:0010466 | |
| MousePheno | abnormal stomach position or orientation | 4.94e-04 | 36 | 13 | 2 | MP:0010807 | |
| MousePheno | abnormal direction of heart looping | 5.51e-04 | 38 | 13 | 2 | MP:0004252 | |
| MousePheno | abnormal right subclavian artery morphology | 6.10e-04 | 40 | 13 | 2 | MP:0010487 | |
| MousePheno | transposition of great arteries | 8.43e-04 | 47 | 13 | 2 | MP:0004110 | |
| MousePheno | dextrocardia | 9.92e-04 | 51 | 13 | 2 | MP:0000644 | |
| MousePheno | decreased heart ventricle size | 1.11e-03 | 54 | 13 | 2 | MP:0031544 | |
| MousePheno | abnormal subclavian artery morphology | 1.20e-03 | 56 | 13 | 2 | MP:0003395 | |
| MousePheno | abnormal digestive organ placement | 1.24e-03 | 57 | 13 | 2 | MP:0003283 | |
| MousePheno | abnormal lung position or orientation | 1.24e-03 | 57 | 13 | 2 | MP:0010853 | |
| MousePheno | right aortic arch | 1.37e-03 | 60 | 13 | 2 | MP:0004158 | |
| MousePheno | situs inversus | 1.37e-03 | 60 | 13 | 2 | MP:0002766 | |
| MousePheno | abnormal left-right axis patterning | 1.71e-03 | 67 | 13 | 2 | MP:0001706 | |
| MousePheno | abnormal inferior vena cava morphology | 1.76e-03 | 68 | 13 | 2 | MP:0006063 | |
| MousePheno | abnormal heart position or orientation | 2.08e-03 | 74 | 13 | 2 | MP:0006065 | |
| MousePheno | abnormal vena cava morphology | 2.25e-03 | 77 | 13 | 2 | MP:0006062 | |
| MousePheno | muscular ventricular septal defect | 2.25e-03 | 77 | 13 | 2 | MP:0010420 | |
| MousePheno | abnormal heart right ventricle size | 2.30e-03 | 78 | 13 | 2 | MP:0010577 | |
| MousePheno | hindlimb paralysis | 2.36e-03 | 79 | 13 | 2 | MP:0000755 | |
| MousePheno | abnormal interventricular septum muscular part morphology | 2.36e-03 | 79 | 13 | 2 | MP:0010498 | |
| MousePheno | limb paralysis | 2.60e-03 | 83 | 13 | 2 | MP:0013147 | |
| MousePheno | atrioventricular septal defect | 2.67e-03 | 84 | 13 | 2 | MP:0010412 | |
| MousePheno | abnormal truncus arteriosus septation | 2.67e-03 | 84 | 13 | 2 | MP:0010454 | |
| MousePheno | abnormal atrioventricular septum morphology | 2.86e-03 | 87 | 13 | 2 | MP:0010592 | |
| MousePheno | small heart | 2.89e-03 | 321 | 13 | 3 | MP:0002188 | |
| MousePheno | atrial septal defect | 2.92e-03 | 88 | 13 | 2 | MP:0010403 | |
| MousePheno | heterotaxia | 3.05e-03 | 90 | 13 | 2 | MP:0004133 | |
| MousePheno | abnormal sexual interaction | 3.33e-03 | 94 | 13 | 2 | MP:0002566 | |
| MousePheno | ventricular hypoplasia | 3.68e-03 | 99 | 13 | 2 | MP:0000279 | |
| MousePheno | abnormal interatrial septum morphology | 4.28e-03 | 107 | 13 | 2 | MP:0000282 | |
| MousePheno | abnormal aortic arch morphology | 5.27e-03 | 119 | 13 | 2 | MP:0004113 | |
| MousePheno | paralysis | 5.27e-03 | 119 | 13 | 2 | MP:0000753 | |
| Domain | CFC | 2.06e-06 | 3 | 16 | 2 | PF09443 | |
| Domain | Cryptic/Cripto_CFC-dom | 2.06e-06 | 3 | 16 | 2 | IPR019011 | |
| Domain | WD40 | 1.29e-03 | 259 | 16 | 3 | PF00400 | |
| Domain | WD40 | 1.42e-03 | 268 | 16 | 3 | SM00320 | |
| Domain | WD40_repeat | 1.49e-03 | 272 | 16 | 3 | IPR001680 | |
| Domain | WD_REPEATS_2 | 1.60e-03 | 279 | 16 | 3 | PS50082 | |
| Domain | WD_REPEATS_REGION | 1.60e-03 | 279 | 16 | 3 | PS50294 | |
| Domain | WD40_repeat_dom | 1.91e-03 | 297 | 16 | 3 | IPR017986 | |
| Domain | - | 2.65e-03 | 333 | 16 | 3 | 2.130.10.10 | |
| Domain | WD40/YVTN_repeat-like_dom | 2.69e-03 | 335 | 16 | 3 | IPR015943 | |
| Domain | Immunoglobulin | 1.12e-02 | 190 | 16 | 2 | IPR013151 | |
| Domain | ig | 1.12e-02 | 190 | 16 | 2 | PF00047 | |
| Domain | EGF | 1.68e-02 | 235 | 16 | 2 | SM00181 | |
| Domain | EGF_3 | 1.68e-02 | 235 | 16 | 2 | PS50026 | |
| Domain | EGF-like_dom | 1.88e-02 | 249 | 16 | 2 | IPR000742 | |
| Domain | EGF_1 | 1.96e-02 | 255 | 16 | 2 | PS00022 | |
| Domain | EGF-like_CS | 2.05e-02 | 261 | 16 | 2 | IPR013032 | |
| Domain | EGF_2 | 2.11e-02 | 265 | 16 | 2 | PS01186 | |
| Domain | WD_REPEATS_1 | 2.31e-02 | 278 | 16 | 2 | PS00678 | |
| Pathway | WP_MIR127_IN_MESENDODERM_DIFFERENTIATION | 5.15e-05 | 12 | 13 | 2 | MM15910 | |
| Pubmed | 2.25e-07 | 2 | 17 | 2 | 11327798 | ||
| Pubmed | 2.25e-07 | 2 | 17 | 2 | 11024280 | ||
| Pubmed | The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer. | 2.25e-07 | 2 | 17 | 2 | 11174844 | |
| Pubmed | 2.25e-07 | 2 | 17 | 2 | 11062482 | ||
| Pubmed | Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. | 6.74e-07 | 3 | 17 | 2 | 16835440 | |
| Pubmed | Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. | 1.35e-06 | 4 | 17 | 2 | 9576836 | |
| Pubmed | 1.35e-06 | 4 | 17 | 2 | 11825688 | ||
| Pubmed | Role of the EGF-CFC gene cripto in cell differentiation and embryo development. | 1.35e-06 | 4 | 17 | 2 | 11992720 | |
| Pubmed | 2.25e-06 | 5 | 17 | 2 | 9053319 | ||
| Pubmed | Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb. | 2.25e-06 | 5 | 17 | 2 | 25224222 | |
| Pubmed | 3.37e-06 | 6 | 17 | 2 | 17991893 | ||
| Pubmed | A role of the cryptic gene in the correct establishment of the left-right axis. | 3.37e-06 | 6 | 17 | 2 | 10574770 | |
| Pubmed | Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. | 3.37e-06 | 6 | 17 | 2 | 12052855 | |
| Pubmed | Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos. | 4.72e-06 | 7 | 17 | 2 | 19906859 | |
| Pubmed | Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. | 4.72e-06 | 7 | 17 | 2 | 10521397 | |
| Pubmed | 6.29e-06 | 8 | 17 | 2 | 21419113 | ||
| Pubmed | Two nodal-responsive enhancers control left-right asymmetric expression of Nodal. | 6.29e-06 | 8 | 17 | 2 | 15736223 | |
| Pubmed | Left-right patterning of the mouse lateral plate requires nodal produced in the node. | 8.08e-06 | 9 | 17 | 2 | 12654299 | |
| Pubmed | 8.08e-06 | 9 | 17 | 2 | 18773496 | ||
| Pubmed | 1.01e-05 | 10 | 17 | 2 | 17913787 | ||
| Pubmed | Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. | 1.23e-05 | 11 | 17 | 2 | 15475956 | |
| Pubmed | Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. | 1.48e-05 | 12 | 17 | 2 | 27100087 | |
| Pubmed | 1.75e-05 | 13 | 17 | 2 | 18550712 | ||
| Pubmed | 2.04e-05 | 14 | 17 | 2 | 17210915 | ||
| Pubmed | 2.35e-05 | 15 | 17 | 2 | 12361961 | ||
| Pubmed | 2.35e-05 | 15 | 17 | 2 | 24780629 | ||
| Pubmed | 2.35e-05 | 15 | 17 | 2 | 33730615 | ||
| Pubmed | Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. | 2.35e-05 | 15 | 17 | 2 | 17360443 | |
| Pubmed | 3.05e-05 | 17 | 17 | 2 | 18697220 | ||
| Pubmed | 3.05e-05 | 17 | 17 | 2 | 19716815 | ||
| Pubmed | 3.05e-05 | 17 | 17 | 2 | 22627279 | ||
| Pubmed | 3.42e-05 | 18 | 17 | 2 | 17936261 | ||
| Pubmed | Tcf3: a transcriptional regulator of axis induction in the early embryo. | 3.42e-05 | 18 | 17 | 2 | 14668413 | |
| Pubmed | 3.42e-05 | 18 | 17 | 2 | 27001747 | ||
| Pubmed | 3.42e-05 | 18 | 17 | 2 | 20346354 | ||
| Pubmed | 3.83e-05 | 19 | 17 | 2 | 28126904 | ||
| Pubmed | 4.25e-05 | 20 | 17 | 2 | 11517919 | ||
| Pubmed | 4.25e-05 | 20 | 17 | 2 | 11440720 | ||
| Pubmed | Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. | 4.70e-05 | 21 | 17 | 2 | 16291790 | |
| Pubmed | Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. | 5.16e-05 | 22 | 17 | 2 | 18241853 | |
| Pubmed | 5.66e-05 | 23 | 17 | 2 | 14623818 | ||
| Pubmed | 6.17e-05 | 24 | 17 | 2 | 18171685 | ||
| Pubmed | The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. | 7.26e-05 | 26 | 17 | 2 | 23651855 | |
| Pubmed | Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. | 7.26e-05 | 26 | 17 | 2 | 23034635 | |
| Pubmed | Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. | 8.44e-05 | 28 | 17 | 2 | 11412024 | |
| Pubmed | 9.70e-05 | 30 | 17 | 2 | 11374901 | ||
| Pubmed | Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. | 9.70e-05 | 30 | 17 | 2 | 15782174 | |
| Pubmed | Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. | 1.11e-04 | 32 | 17 | 2 | 16964240 | |
| Pubmed | 1.40e-04 | 36 | 17 | 2 | 17289661 | ||
| Pubmed | 1.40e-04 | 36 | 17 | 2 | 27606604 | ||
| Pubmed | Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. | 1.73e-04 | 40 | 17 | 2 | 23825951 | |
| Pubmed | PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. | 2.61e-04 | 49 | 17 | 2 | 31973889 | |
| Pubmed | Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. | 2.94e-04 | 52 | 17 | 2 | 24591637 | |
| Pubmed | IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. | 3.66e-04 | 58 | 17 | 2 | 21642987 | |
| Pubmed | 4.59e-04 | 65 | 17 | 2 | 32521226 | ||
| Cytoband | 7p22.1 | 1.38e-04 | 47 | 17 | 2 | 7p22.1 | |
| Cytoband | 2q21.1 | 2.11e-04 | 58 | 17 | 2 | 2q21.1 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr7p22 | 1.12e-03 | 134 | 17 | 2 | chr7p22 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr2q21 | 1.41e-03 | 151 | 17 | 2 | chr2q21 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr1q23 | 3.13e-03 | 226 | 17 | 2 | chr1q23 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr21q22 | 8.43e-03 | 377 | 17 | 2 | chr21q22 | |
| GeneFamily | WD repeat domain containing|DDB1 and CUL4 associated factors | 4.19e-05 | 18 | 10 | 2 | 498 | |
| GeneFamily | WD repeat domain containing | 3.35e-04 | 262 | 10 | 3 | 362 | |
| GeneFamily | Immunoglobulin like domain containing | 4.82e-03 | 193 | 10 | 2 | 594 | |
| Disease | double outlet right ventricle (implicated_via_orthology) | 8.27e-07 | 3 | 16 | 2 | DOID:6406 (implicated_via_orthology) | |
| Disease | right atrial isomerism (implicated_via_orthology) | 1.65e-06 | 4 | 16 | 2 | DOID:0060856 (implicated_via_orthology) | |
| Disease | dextro-looped transposition of the great arteries (implicated_via_orthology) | 1.65e-06 | 4 | 16 | 2 | DOID:0060770 (implicated_via_orthology) | |
| Disease | visceral heterotaxy (is_implicated_in) | 1.81e-05 | 12 | 16 | 2 | DOID:0050545 (is_implicated_in) | |
| Disease | visceral heterotaxy (implicated_via_orthology) | 1.82e-04 | 37 | 16 | 2 | DOID:0050545 (implicated_via_orthology) | |
| Disease | stroke | 2.71e-03 | 144 | 16 | 2 | EFO_0000712 | |
| Disease | basophil percentage of leukocytes | 7.51e-03 | 243 | 16 | 2 | EFO_0007992 | |
| Disease | serum alanine aminotransferase measurement | 1.07e-02 | 869 | 16 | 3 | EFO_0004735 | |
| Disease | Parkinson disease | 1.28e-02 | 321 | 16 | 2 | MONDO_0005180 | |
| Disease | age at first sexual intercourse measurement | 1.79e-02 | 383 | 16 | 2 | EFO_0009749 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| NLGNSYQREKHNGGR | 21 | P0CG36 | |
| YYAKKKRRHQQGQGD | 111 | Q13627 | |
| NLGNSYQREKHNGGR | 21 | P0CG37 | |
| TGYQRQLNYKHQDGS | 1016 | P20742 | |
| GKRHGKGSIYYNQEG | 186 | P0C881 | |
| GKRHGKGSIYYNQEG | 186 | B2RC85 | |
| GAQYSKRFKGHRNNT | 456 | P0C7V8 | |
| GAQYVKRYKGHRNNA | 421 | Q5TAQ9 | |
| QRHQGGRYYCKAENG | 101 | Q7Z553 | |
| HVNRNGFNRSYAGKN | 1691 | Q460N5 | |
| NGHYHNGILNGKYKR | 516 | Q16880 | |
| QGKQKGYNHGQGSYS | 771 | Q12906 | |
| GRSGGRKYNTFHKNA | 1796 | Q9NSI6 | |
| YLQNGKGRKYFHHNS | 141 | P08637 | |
| YGKSQRRGGHQNNYK | 316 | Q99729 | |
| HGQKGQHYFGQKDQQ | 41 | Q02383 | |
| GKNHGKKLRNYYAAN | 91 | Q9HA38 |