Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnodal binding

CFC1B CFC1

1.47e-058152GO:0038100
GeneOntologyMolecularFunctionactivin receptor binding

CFC1B CFC1

4.77e-0514152GO:0070697
GeneOntologyMolecularFunctiontransmembrane receptor protein serine/threonine kinase binding

CFC1B CFC1

1.83e-0427152GO:0070696
GeneOntologyMolecularFunctionreceptor serine/threonine kinase binding

CFC1B CFC1

3.09e-0435152GO:0033612
GeneOntologyMolecularFunctionprotease binding

PZP SEMG2

7.94e-03181152GO:0002020
GeneOntologyBiologicalProcessleft lung morphogenesis

CFC1B CFC1

2.96e-064152GO:0060460
GeneOntologyBiologicalProcessleft lung development

CFC1B CFC1

4.93e-065152GO:0060459
GeneOntologyBiologicalProcessatrial septum morphogenesis

CFC1B CFC1

7.50e-0518152GO:0060413
GeneOntologyBiologicalProcessatrial septum development

CFC1B CFC1

1.47e-0425152GO:0003283
GeneOntologyBiologicalProcessnodal signaling pathway

CFC1B CFC1

1.59e-0426152GO:0038092
GeneOntologyBiologicalProcesscardiac atrium morphogenesis

CFC1B CFC1

2.90e-0435152GO:0003209
GeneOntologyBiologicalProcesscardiac atrium development

CFC1B CFC1

4.18e-0442152GO:0003230
GeneOntologyBiologicalProcessspleen development

CFC1B CFC1

6.41e-0452152GO:0048536
GeneOntologyBiologicalProcessdigestive tract morphogenesis

CFC1B CFC1

8.25e-0459152GO:0048546
GeneOntologyBiologicalProcessactivin receptor signaling pathway

CFC1B CFC1

8.53e-0460152GO:0032924
GeneOntologyCellularComponentCul4-RING E3 ubiquitin ligase complex

DCAF8L2 DCAF8

4.30e-0438172GO:0080008
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

HNRNPAB RSPH10B BRWD1

2.01e-03317173GO:0032838
GeneOntologyCellularComponentmotile cilium

RSPH10B2 RSPH10B BRWD1

2.77e-03355173GO:0031514
GeneOntologyCellularComponentcytoplasmic region

HNRNPAB RSPH10B BRWD1

2.88e-03360173GO:0099568
GeneOntologyCellularComponentside of membrane

FCGR3A MDGA2 CFC1B CFC1

4.69e-03875174GO:0098552
MousePhenototal anomalous pulmonary venous connection, intracardiac

CFC1B CFC1

7.98e-072132MP:0010443
MousePhenototal anomalous pulmonary venous connection

CFC1B CFC1

4.79e-064132MP:0010441
MousePhenounbalanced complete common atrioventricular canal

CFC1B CFC1

4.79e-064132MP:0011673
MousePhenosuperior-inferior ventricles

CFC1B CFC1

1.67e-057132MP:0011254
MousePhenoaccessory spleen

CFC1B CFC1

2.86e-059132MP:0003342
MousePhenoabnormal direction of embryo turning

CFC1B CFC1

6.19e-0513132MP:0004190
MousePhenod-loop transposition of the great arteries

CFC1B CFC1

6.19e-0513132MP:0011665
MousePhenoheart right ventricle hypoplasia

CFC1B CFC1

7.22e-0514132MP:0010422
MousePhenoanomalous pulmonary venous connection

CFC1B CFC1

8.33e-0515132MP:0010440
MousePhenoabnormal copulatory plug deposition

SEMG2 DCAF8

9.51e-0516132MP:0030982
MousePhenomesocardia

CFC1B CFC1

1.50e-0420132MP:0000650
MousePhenoabnormal azygos vein morphology

CFC1B CFC1

1.50e-0420132MP:0011569
MousePhenocommon atrium

CFC1B CFC1

2.18e-0424132MP:0010406
MousePhenoabnormal copulation behavior

SEMG2 DCAF8

2.18e-0424132MP:0009697
MousePhenoright pulmonary isomerism

CFC1B CFC1

2.37e-0425132MP:0000531
MousePhenodecreased heart right ventricle size

CFC1B CFC1

2.37e-0425132MP:0003649
MousePhenocomplete atrioventricular septal defect

CFC1B CFC1

2.56e-0426132MP:0010413
MousePhenoabnormal left lung morphology

CFC1B CFC1

2.98e-0428132MP:0009569
MousePhenoabsent spleen

CFC1B CFC1

3.20e-0429132MP:0000690
MousePhenoright-sided isomerism

CFC1B CFC1

3.42e-0430132MP:0000508
MousePhenoright-sided stomach

CFC1B CFC1

3.66e-0431132MP:0010808
MousePhenoleft-sided isomerism

CFC1B CFC1

4.40e-0434132MP:0000542
MousePhenovascular ring

CFC1B CFC1

4.67e-0435132MP:0010466
MousePhenoabnormal stomach position or orientation

CFC1B CFC1

4.94e-0436132MP:0010807
MousePhenoabnormal direction of heart looping

CFC1B CFC1

5.51e-0438132MP:0004252
MousePhenoabnormal right subclavian artery morphology

CFC1B CFC1

6.10e-0440132MP:0010487
MousePhenotransposition of great arteries

CFC1B CFC1

8.43e-0447132MP:0004110
MousePhenodextrocardia

CFC1B CFC1

9.92e-0451132MP:0000644
MousePhenodecreased heart ventricle size

CFC1B CFC1

1.11e-0354132MP:0031544
MousePhenoabnormal subclavian artery morphology

CFC1B CFC1

1.20e-0356132MP:0003395
MousePhenoabnormal digestive organ placement

CFC1B CFC1

1.24e-0357132MP:0003283
MousePhenoabnormal lung position or orientation

CFC1B CFC1

1.24e-0357132MP:0010853
MousePhenoright aortic arch

CFC1B CFC1

1.37e-0360132MP:0004158
MousePhenositus inversus

CFC1B CFC1

1.37e-0360132MP:0002766
MousePhenoabnormal left-right axis patterning

CFC1B CFC1

1.71e-0367132MP:0001706
MousePhenoabnormal inferior vena cava morphology

CFC1B CFC1

1.76e-0368132MP:0006063
MousePhenoabnormal heart position or orientation

CFC1B CFC1

2.08e-0374132MP:0006065
MousePhenoabnormal vena cava morphology

CFC1B CFC1

2.25e-0377132MP:0006062
MousePhenomuscular ventricular septal defect

CFC1B CFC1

2.25e-0377132MP:0010420
MousePhenoabnormal heart right ventricle size

CFC1B CFC1

2.30e-0378132MP:0010577
MousePhenohindlimb paralysis

UGT8 MDGA2

2.36e-0379132MP:0000755
MousePhenoabnormal interventricular septum muscular part morphology

CFC1B CFC1

2.36e-0379132MP:0010498
MousePhenolimb paralysis

UGT8 MDGA2

2.60e-0383132MP:0013147
MousePhenoatrioventricular septal defect

CFC1B CFC1

2.67e-0384132MP:0010412
MousePhenoabnormal truncus arteriosus septation

CFC1B CFC1

2.67e-0384132MP:0010454
MousePhenoabnormal atrioventricular septum morphology

CFC1B CFC1

2.86e-0387132MP:0010592
MousePhenosmall heart

DYRK1A CFC1B CFC1

2.89e-03321133MP:0002188
MousePhenoatrial septal defect

CFC1B CFC1

2.92e-0388132MP:0010403
MousePhenoheterotaxia

CFC1B CFC1

3.05e-0390132MP:0004133
MousePhenoabnormal sexual interaction

SEMG2 DCAF8

3.33e-0394132MP:0002566
MousePhenoventricular hypoplasia

CFC1B CFC1

3.68e-0399132MP:0000279
MousePhenoabnormal interatrial septum morphology

CFC1B CFC1

4.28e-03107132MP:0000282
MousePhenoabnormal aortic arch morphology

CFC1B CFC1

5.27e-03119132MP:0004113
MousePhenoparalysis

UGT8 MDGA2

5.27e-03119132MP:0000753
DomainCFC

CFC1B CFC1

2.06e-063162PF09443
DomainCryptic/Cripto_CFC-dom

CFC1B CFC1

2.06e-063162IPR019011
DomainWD40

DCAF8L2 DCAF8 BRWD1

1.29e-03259163PF00400
DomainWD40

DCAF8L2 DCAF8 BRWD1

1.42e-03268163SM00320
DomainWD40_repeat

DCAF8L2 DCAF8 BRWD1

1.49e-03272163IPR001680
DomainWD_REPEATS_2

DCAF8L2 DCAF8 BRWD1

1.60e-03279163PS50082
DomainWD_REPEATS_REGION

DCAF8L2 DCAF8 BRWD1

1.60e-03279163PS50294
DomainWD40_repeat_dom

DCAF8L2 DCAF8 BRWD1

1.91e-03297163IPR017986
Domain-

DCAF8L2 DCAF8 BRWD1

2.65e-033331632.130.10.10
DomainWD40/YVTN_repeat-like_dom

DCAF8L2 DCAF8 BRWD1

2.69e-03335163IPR015943
DomainImmunoglobulin

FCGR3A MDGA2

1.12e-02190162IPR013151
Domainig

FCGR3A MDGA2

1.12e-02190162PF00047
DomainEGF

CFC1B CFC1

1.68e-02235162SM00181
DomainEGF_3

CFC1B CFC1

1.68e-02235162PS50026
DomainEGF-like_dom

CFC1B CFC1

1.88e-02249162IPR000742
DomainEGF_1

CFC1B CFC1

1.96e-02255162PS00022
DomainEGF-like_CS

CFC1B CFC1

2.05e-02261162IPR013032
DomainEGF_2

CFC1B CFC1

2.11e-02265162PS01186
DomainWD_REPEATS_1

DCAF8 BRWD1

2.31e-02278162PS00678
PathwayWP_MIR127_IN_MESENDODERM_DIFFERENTIATION

CFC1B CFC1

5.15e-0512132MM15910
Pubmed

Identification of differentially expressed genes in mouse development using differential display and in situ hybridization.

CFC1B CFC1

2.25e-07217211327798
Pubmed

Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis.

CFC1B CFC1

2.25e-07217211024280
Pubmed

The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.

CFC1B CFC1

2.25e-07217211174844
Pubmed

Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.

CFC1B CFC1

2.25e-07217211062482
Pubmed

Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.

CFC1B CFC1

6.74e-07317216835440
Pubmed

Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.

CFC1B CFC1

1.35e-0641729576836
Pubmed

Cripto in tumors and embryo development.

CFC1B CFC1

1.35e-06417211825688
Pubmed

Role of the EGF-CFC gene cripto in cell differentiation and embryo development.

CFC1B CFC1

1.35e-06417211992720
Pubmed

A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.

CFC1B CFC1

2.25e-0651729053319
Pubmed

Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.

CFC1B CFC1

2.25e-06517225224222
Pubmed

GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.

CFC1B CFC1

3.37e-06617217991893
Pubmed

A role of the cryptic gene in the correct establishment of the left-right axis.

CFC1B CFC1

3.37e-06617210574770
Pubmed

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.

CFC1B CFC1

3.37e-06617212052855
Pubmed

Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.

CFC1B CFC1

4.72e-06717219906859
Pubmed

Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation.

CFC1B CFC1

4.72e-06717210521397
Pubmed

Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos.

CFC1B CFC1

6.29e-06817221419113
Pubmed

Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.

CFC1B CFC1

6.29e-06817215736223
Pubmed

Left-right patterning of the mouse lateral plate requires nodal produced in the node.

CFC1B CFC1

8.08e-06917212654299
Pubmed

Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic.

CFC1B CFC1

8.08e-06917218773496
Pubmed

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.

CFC1B CFC1

1.01e-051017217913787
Pubmed

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.

CFC1B CFC1

1.23e-051117215475956
Pubmed

Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

DYRK1A BRWD1

1.48e-051217227100087
Pubmed

BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.

CFC1B CFC1

1.75e-051317218550712
Pubmed

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

CFC1B CFC1

2.04e-051417217210915
Pubmed

Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.

CFC1B CFC1

2.35e-051517212361961
Pubmed

Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway.

CFC1B CFC1

2.35e-051517224780629
Pubmed

Maternal Cripto is critical for proper development of the mouse placenta and the placental vasculature.

CFC1B CFC1

2.35e-051517233730615
Pubmed

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.

CFC1B CFC1

2.35e-051517217360443
Pubmed

Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.

CFC1B CFC1

3.05e-051717218697220
Pubmed

Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.

CFC1B CFC1

3.05e-051717219716815
Pubmed

Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.

CFC1B CFC1

3.05e-051717222627279
Pubmed

Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.

CFC1B CFC1

3.42e-051817217936261
Pubmed

Tcf3: a transcriptional regulator of axis induction in the early embryo.

CFC1B CFC1

3.42e-051817214668413
Pubmed

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

PARP14 FCGR3A

3.42e-051817227001747
Pubmed

Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.

CFC1B CFC1

3.42e-051817220346354
Pubmed

Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.

CFC1B CFC1

3.83e-051917228126904
Pubmed

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.

CFC1B CFC1

4.25e-052017211517919
Pubmed

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.

CFC1B CFC1

4.25e-052017211440720
Pubmed

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.

CFC1B CFC1

4.70e-052117216291790
Pubmed

Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.

CFC1B CFC1

5.16e-052217218241853
Pubmed

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

CFC1B CFC1

5.66e-052317214623818
Pubmed

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.

CFC1B CFC1

6.17e-052417218171685
Pubmed

The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.

CFC1B CFC1

7.26e-052617223651855
Pubmed

Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.

CFC1B CFC1

7.26e-052617223034635
Pubmed

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.

CFC1B CFC1

8.44e-052817211412024
Pubmed

Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.

DYRK1A BRWD1

9.70e-053017211374901
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

HNRNPAB ILF3

9.70e-053017215782174
Pubmed

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

DCAF8 BRWD1

1.11e-043217216964240
Pubmed

Molecular composition of IMP1 ribonucleoprotein granules.

HNRNPAB ILF3

1.40e-043617217289661
Pubmed

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

CFC1B CFC1

1.40e-043617227606604
Pubmed

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

HNRNPAB ILF3

1.73e-044017223825951
Pubmed

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.

DCAF8 BRWD1

2.61e-044917231973889
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

HNRNPAB ILF3

2.94e-045217224591637
Pubmed

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

HNRNPAB ILF3

3.66e-045817221642987
Pubmed

The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.

HNRNPAB ILF3

4.59e-046517232521226
Cytoband7p22.1

RSPH10B2 RSPH10B

1.38e-04471727p22.1
Cytoband2q21.1

CFC1B CFC1

2.11e-04581722q21.1
CytobandEnsembl 112 genes in cytogenetic band chr7p22

RSPH10B2 RSPH10B

1.12e-03134172chr7p22
CytobandEnsembl 112 genes in cytogenetic band chr2q21

CFC1B CFC1

1.41e-03151172chr2q21
CytobandEnsembl 112 genes in cytogenetic band chr1q23

FCGR3A DCAF8

3.13e-03226172chr1q23
CytobandEnsembl 112 genes in cytogenetic band chr21q22

DYRK1A BRWD1

8.43e-03377172chr21q22
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF8 BRWD1

4.19e-0518102498
GeneFamilyWD repeat domain containing

DCAF8L2 DCAF8 BRWD1

3.35e-04262103362
GeneFamilyImmunoglobulin like domain containing

FCGR3A MDGA2

4.82e-03193102594
Diseasedouble outlet right ventricle (implicated_via_orthology)

CFC1B CFC1

8.27e-073162DOID:6406 (implicated_via_orthology)
Diseaseright atrial isomerism (implicated_via_orthology)

CFC1B CFC1

1.65e-064162DOID:0060856 (implicated_via_orthology)
Diseasedextro-looped transposition of the great arteries (implicated_via_orthology)

CFC1B CFC1

1.65e-064162DOID:0060770 (implicated_via_orthology)
Diseasevisceral heterotaxy (is_implicated_in)

CFC1B CFC1

1.81e-0512162DOID:0050545 (is_implicated_in)
Diseasevisceral heterotaxy (implicated_via_orthology)

CFC1B CFC1

1.82e-0437162DOID:0050545 (implicated_via_orthology)
Diseasestroke

DYRK1A ILF3

2.71e-03144162EFO_0000712
Diseasebasophil percentage of leukocytes

DYRK1A FCGR3A

7.51e-03243162EFO_0007992
Diseaseserum alanine aminotransferase measurement

DYRK1A FCGR3A BRWD1

1.07e-02869163EFO_0004735
DiseaseParkinson disease

DYRK1A MDGA2

1.28e-02321162MONDO_0005180
Diseaseage at first sexual intercourse measurement

MDGA2 BRWD1

1.79e-02383162EFO_0009749

Protein segments in the cluster

PeptideGeneStartEntry
NLGNSYQREKHNGGR

CFC1B

21

P0CG36
YYAKKKRRHQQGQGD

DYRK1A

111

Q13627
NLGNSYQREKHNGGR

CFC1

21

P0CG37
TGYQRQLNYKHQDGS

PZP

1016

P20742
GKRHGKGSIYYNQEG

RSPH10B

186

P0C881
GKRHGKGSIYYNQEG

RSPH10B2

186

B2RC85
GAQYSKRFKGHRNNT

DCAF8L2

456

P0C7V8
GAQYVKRYKGHRNNA

DCAF8

421

Q5TAQ9
QRHQGGRYYCKAENG

MDGA2

101

Q7Z553
HVNRNGFNRSYAGKN

PARP14

1691

Q460N5
NGHYHNGILNGKYKR

UGT8

516

Q16880
QGKQKGYNHGQGSYS

ILF3

771

Q12906
GRSGGRKYNTFHKNA

BRWD1

1796

Q9NSI6
YLQNGKGRKYFHHNS

FCGR3A

141

P08637
YGKSQRRGGHQNNYK

HNRNPAB

316

Q99729
HGQKGQHYFGQKDQQ

SEMG2

41

Q02383
GKNHGKKLRNYYAAN

ZMAT3

91

Q9HA38