Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25 CTSD SPPL2C

6.13e-1137737GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25 CTSD SPPL2C

7.49e-1138737GO:0070001
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-8 ERVK-7 TERT

1.60e-0714734GO:0003964
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-6 AURKC STK36 FLT1 BMPR1B STK17A ERVK-8 PAK1 MAP3K9 DLG1 ERVK-7 PI4KAP2 TERT CASK

6.42e-069387314GO:0016772
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-8 ERVK-7

7.57e-0611733GO:0004523
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-8 ERVK-7 TERT

1.10e-0538734GO:0034061
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 LONP1 ERVK-8 ERVK-19 ERVK-7 ERVK-25 CTSD SPPL2C USP33

2.63e-05430739GO:0004175
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-8 ERVK-7

5.95e-0521733GO:0035613
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 LONP1 ERVK-8 ERVK-19 ERVK-7 ERVK-25 CTSD SPPL2C AGTPBP1 USP33

1.28e-046547310GO:0008233
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7

3.33e-0437733GO:0016891
GeneOntologyMolecularFunctionkinase activity

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 DLG1 PI4KAP2 CASK

4.45e-047647310GO:0016301
GeneOntologyMolecularFunctionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

ALDH4A1 ALDH7A1

4.67e-049732GO:0043878
GeneOntologyMolecularFunctionselenium binding

SELENBP1 GPX4

5.82e-0410732GO:0008430
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7

6.36e-0446733GO:0016893
GeneOntologyMolecularFunctionstructural constituent of postsynaptic density

DLG1 DLG3

7.10e-0411732GO:0098919
GeneOntologyMolecularFunctionguanylate kinase activity

DLG1 CASK

7.10e-0411732GO:0004385
GeneOntologyMolecularFunctionstructural constituent of postsynaptic specialization

DLG1 DLG3

1.00e-0313732GO:0098879
GeneOntologyMolecularFunctionkinesin binding

DLG1 CLSTN1 MAPK8IP3

1.07e-0355733GO:0019894
GeneOntologyMolecularFunctionPDZ domain binding

FZD4 DLG1 DLG3 CASK

1.07e-03123734GO:0030165
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

AURKC STK36 BMPR1B STK17A PAK1 MAP3K9 CASK

1.21e-03446737GO:0004674
GeneOntologyMolecularFunctionprotein kinase binding

MAG CACNB2 PAK1 DLG1 DLG3 TRIM6 BANK1 CRKL MAPK8IP3 CASK

1.24e-038737310GO:0019901
GeneOntologyMolecularFunctionaldehyde dehydrogenase (NAD+) activity

ALDH4A1 ALDH7A1

1.34e-0315732GO:0004029
GeneOntologyMolecularFunctionprotein kinase activity

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 CASK

1.53e-03600738GO:0004672
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 ERVK-8 ERVK-7 CNOT8

1.56e-03136734GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ENDOD1 ERVK-8 ERVK-7

1.56e-03136734GO:0004519
GeneOntologyMolecularFunctionnuclease activity

ERVK-6 ENDOD1 ERVK-8 ERVK-7 CNOT8

1.57e-03231735GO:0004518
GeneOntologyMolecularFunctionaldehyde dehydrogenase [NAD(P)+] activity

ALDH4A1 ALDH7A1

1.73e-0317732GO:0004030
GeneOntologyMolecularFunctionprotein serine kinase activity

AURKC STK36 STK17A PAK1 MAP3K9 CASK

2.12e-03363736GO:0106310
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 ERVK-8 ERVK-7 TERT

2.34e-03152734GO:0016779
GeneOntologyMolecularFunctionkinase binding

MAG CACNB2 PAK1 DLG1 DLG3 TRIM6 BANK1 CRKL MAPK8IP3 CASK

2.67e-039697310GO:0019900
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-8 ERVK-7

3.04e-0379733GO:0004521
GeneOntologyMolecularFunctionnucleoside monophosphate kinase activity

DLG1 CASK

3.17e-0323732GO:0050145
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 TYW1B ERVK-8 ERVK-7 TERT CNOT8

4.19e-03417736GO:0140098
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 CASK

4.27e-03709738GO:0016773
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 ERVK-8 ERVK-19 ALAD ERVK-7 TRIM6 AGTPBP1 USP33 ADH1B

5.06e-03891739GO:0008270
GeneOntologyMolecularFunctionstructural constituent of postsynapse

DLG1 DLG3

6.09e-0332732GO:0099186
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-8 ERVK-7

1.19e-0513733GO:0015074
MousePhenopremaxilla hypoplasia

IFT140 DLG1 CRKL

9.28e-0610613MP:0004871
DomainGuanylate_kin

CACNB2 DLG1 DLG3 CASK

2.26e-0626684PF00625
DomainGK/Ca_channel_bsu

CACNB2 DLG1 DLG3 CASK

2.26e-0626684IPR008145
DomainGuanylate_kin-like_dom

CACNB2 DLG1 DLG3 CASK

2.26e-0626684IPR008144
DomainGuKc

CACNB2 DLG1 DLG3 CASK

2.26e-0626684SM00072
DomainRT_dom

ERVK-6 TERT

1.31e-052682IPR000477
DomainRVT_1

ERVK-6 TERT

1.31e-052682PF00078
DomainRT_POL

ERVK-6 TERT

1.31e-052682PS50878
DomainGuanylate_kinase_CS

DLG1 DLG3 CASK

2.50e-0516683IPR020590
DomainCADHERIN_1

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

5.71e-05113685PS00232
DomainCadherin

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

5.71e-05113685PF00028
DomainCADHERIN_2

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

5.95e-05114685PS50268
Domain-

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

5.95e-051146852.60.40.60
DomainCA

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

6.20e-05115685SM00112
DomainCadherin-like

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

6.47e-05116685IPR015919
DomainCadherin

PCDHGB5 PCDH15 PCDHGB4 CLSTN1 PCDHGA8

7.01e-05118685IPR002126
DomainGUANYLATE_KINASE_2

DLG1 DLG3 CASK

7.76e-0523683PS50052
DomainGUANYLATE_KINASE_1

DLG1 DLG3 CASK

7.76e-0523683PS00856
DomainMAGUK_N_PEST

DLG1 DLG3

7.80e-054682PF10608
DomainPDZ_assoc

DLG1 DLG3

7.80e-054682PF10600
DomainDLG1_PEST_dom

DLG1 DLG3

7.80e-054682IPR019590
DomainPDZ_assoc

DLG1 DLG3

7.80e-054682IPR019583
DomainMAGUK_N_PEST

DLG1 DLG3

7.80e-054682SM01277
DomainDLG1

DLG1 DLG3

7.80e-054682IPR016313
DomainSH3

CACNB2 MAP3K9 DLG1 DLG3 CRKL CASK

1.34e-04216686SM00326
DomainSH3

CACNB2 MAP3K9 DLG1 DLG3 CRKL CASK

1.34e-04216686PS50002
DomainSH3_domain

CACNB2 MAP3K9 DLG1 DLG3 CRKL CASK

1.49e-04220686IPR001452
DomainPROTEIN_KINASE_ATP

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 CASK

2.54e-04459688PS00107
DomainSH3_2

MAP3K9 DLG1 CRKL CASK

2.73e-0486684IPR011511
DomainSH3_2

MAP3K9 DLG1 CRKL CASK

2.73e-0486684PF07653
DomainSer/Thr_kinase_AS

AURKC STK36 BMPR1B STK17A PAK1 MAP3K9 CASK

3.13e-04357687IPR008271
DomainS_TKc

AURKC STK36 BMPR1B STK17A PAK1 MAP3K9 CASK

3.24e-04359687SM00220
DomainCadherin_tail

PCDHGB5 PCDHGB4 PCDHGA8

3.28e-0437683PF15974
DomainCadherin_CBD

PCDHGB5 PCDHGB4 PCDHGA8

3.28e-0437683IPR031904
DomainPROTEIN_KINASE_ST

AURKC STK36 BMPR1B STK17A PAK1 MAP3K9 CASK

3.41e-04362687PS00108
DomainProt_kinase_dom

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 CASK

3.89e-04489688IPR000719
DomainPROTEIN_KINASE_DOM

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 CASK

4.10e-04493688PS50011
DomainProtein_kinase_ATP_BS

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9

4.48e-04379687IPR017441
DomainPkinase

AURKC STK36 BMPR1B STK17A PAK1 MAP3K9 CASK

4.63e-04381687PF00069
DomainCadherin_C

PCDHGB5 PCDHGB4 PCDHGA8

4.79e-0442683IPR032455
DomainCadherin_C_2

PCDHGB5 PCDHGB4 PCDHGA8

4.79e-0442683PF16492
DomainCadherin_CS

PCDHGB5 PCDH15 PCDHGB4 PCDHGA8

6.71e-04109684IPR020894
DomainKinase-like_dom

AURKC STK36 FLT1 BMPR1B STK17A PAK1 MAP3K9 CASK

7.65e-04542688IPR011009
DomainWWE

DDHD2 HUWE1

8.42e-0412682PS50918
DomainWWE

DDHD2 HUWE1

8.42e-0412682PF02825
DomainWWE-dom

DDHD2 HUWE1

8.42e-0412682IPR004170
DomainASP_PROTEASE

ERVK-6 CTSD

8.42e-0412682PS00141
DomainL27

DLG1 CASK

9.93e-0413682SM00569
DomainAspartic_peptidase_AS

ERVK-6 CTSD

9.93e-0413682IPR001969
DomainL27

DLG1 CASK

9.93e-0413682PS51022
DomainL27_dom

DLG1 CASK

9.93e-0413682IPR004172
DomainAld_DH_CS_GLU

ALDH4A1 ALDH7A1

1.52e-0316682IPR029510
DomainAld_DH_CS_CYS

ALDH4A1 ALDH7A1

1.71e-0317682IPR016160
DomainCadherin_2

PCDHGB5 PCDHGB4 PCDHGA8

1.72e-0365683PF08266
DomainCadherin_N

PCDHGB5 PCDHGB4 PCDHGA8

1.72e-0365683IPR013164
DomainALDEHYDE_DEHYDR_GLU

ALDH4A1 ALDH7A1

1.92e-0318682PS00687
DomainALDEHYDE_DEHYDR_CYS

ALDH4A1 ALDH7A1

1.92e-0318682PS00070
DomainAld_DH_C

ALDH4A1 ALDH7A1

2.15e-0319682IPR016163
DomainAld_DH_N

ALDH4A1 ALDH7A1

2.15e-0319682IPR016162
DomainAld_DH/histidinol_DH

ALDH4A1 ALDH7A1

2.15e-0319682IPR016161
Domain-

ALDH4A1 ALDH7A1

2.15e-03196823.40.605.10
DomainAldedh

ALDH4A1 ALDH7A1

2.15e-0319682PF00171
DomainAldehyde_DH_dom

ALDH4A1 ALDH7A1

2.15e-0319682IPR015590
Domain-

ALDH4A1 ALDH7A1

2.15e-03196823.40.309.10
DomainSH3_1

CACNB2 DLG1 DLG3 CRKL

3.02e-03164684PF00018
DomainG_patch

ERVK-6 GPATCH8

3.15e-0323682SM00443
DomainG_patch_dom

ERVK-6 GPATCH8

3.15e-0323682IPR000467
DomainG_PATCH

ERVK-6 GPATCH8

3.15e-0323682PS50174
DomainG-patch

ERVK-6 GPATCH8

3.15e-0323682PF01585
PathwayBIOCARTA_PDZS_PATHWAY

DLG1 DLG3 CASK

3.93e-0518533M22001
PathwayREACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS

CYP3A43 GPX4 PTGS2

7.35e-0522533MM15614
PathwayREACTOME_SYNTHESIS_OF_15_EICOSATETRAENOIC_ACID_DERIVATIVES

GPX4 PTGS2

2.06e-046532M27141
PathwayREACTOME_SYNTHESIS_OF_15_EICOSATETRAENOIC_ACID_DERIVATIVES

GPX4 PTGS2

2.06e-046532MM14862
PathwayREACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS

GPX4 PTGS2

2.06e-046532M27890
PathwayREACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS

GPX4 PTGS2

2.06e-046532MM15615
PathwayREACTOME_NRCAM_INTERACTIONS

DLG1 DLG3

2.88e-047532M27378
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

CYP3A43 PTGS2

3.83e-048532MM1547
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7

8.84e-08573312629516
Pubmed

Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97.

DLG1 DLG3 CASK

4.93e-07873312351654
Pubmed

The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.

DLG1 DLG3 CASK

7.38e-07973317938206
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25

1.68e-069473521542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19

1.93e-061273314557543
Pubmed

Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4.

SELENBP1 GPX4

4.35e-06273238518851
Pubmed

Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells.

TERT PTGS2

4.35e-06273218717758
Pubmed

hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions.

DLG1 CASK

4.35e-06273210993877
Pubmed

Cyclooxygenase-2 overexpression inhibits cathepsin D-mediated cleavage of plasminogen to the potent antiangiogenic factor angiostatin.

CTSD PTGS2

4.35e-06273212970159
Pubmed

Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure.

SLC15A2 ALAD

4.35e-06273219723536
Pubmed

p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus.

PAK1 PTGS2

4.35e-06273227296803
Pubmed

δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 and peptide transporter 2*2 haplotype may differentially mediate lead exposure in male children.

SLC15A2 ALAD

4.35e-06273221327641
Pubmed

Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.

SELENBP1 USP33

4.35e-06273219118533
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

4.35e-0627329060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

4.35e-0627329460924
Pubmed

δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children.

SLC15A2 ALAD

4.35e-06273225514583
Pubmed

Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102.

DLG1 DLG3

4.35e-06273218618587
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

PRPF31 LONP1 GTF2I SELENBP1 GPX4 DLG1 UNC45A HUWE1 CRKL USP33 CASK

7.70e-061005731119615732
Pubmed

Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.

DLG1 DLG3 CASK

8.39e-061973315024025
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

SLC15A2 ALDH4A1 PTGS2 ADH1B

1.17e-056673419898482
Pubmed

A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination.

TMEM106B CTSD

1.30e-05373232572497
Pubmed

Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.

DLG1 CASK

1.30e-05373212511555
Pubmed

Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1.

CTSD TERT

1.30e-05373226519755
Pubmed

Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.

DLG1 DLG3

1.30e-05373212175853
Pubmed

Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

DLG1 DLG3

1.30e-05373225268382
Pubmed

[Effect of GPX4 on proliferation and metastasis of renal clear cell carcinoma and its relationship with expression of IGF-1R and COX-2].

GPX4 PTGS2

1.30e-05373231818070
Pubmed

A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia.

DLG1 CASK

1.30e-05373211865057
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

1.30e-05373210516026
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

DLG1 DLG3 CASK

1.52e-052373316637659
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

CACNB2 ARHGAP15 TYW1B RNASEH2C MAP3K9 DLG1 GPATCH8 HUWE1 PTGS2 CNOT8 STAT6

1.56e-051084731111544199
Pubmed

SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.

DLG1 DLG3 CASK

1.97e-052573327480238
Pubmed

IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6.

PTGS2 STAT6

2.60e-05473221277633
Pubmed

Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting.

DLG1 DLG3

2.60e-05473210595517
Pubmed

Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.

DLG1 CASK

2.60e-05473212151521
Pubmed

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

HUWE1 CTSD

2.60e-05473221298030
Pubmed

CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors.

DLG1 CASK

2.60e-05473223864692
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7

2.60e-05473210469592
Pubmed

ArhGAP15, a novel human RacGAP protein with GTPase binding property.

ARHGAP15 PAK1

2.60e-05473212650940
Pubmed

Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.

DLG1 DLG3

2.60e-05473221031555
Pubmed

Synaptic scaffold evolution generated components of vertebrate cognitive complexity.

DLG1 DLG3

2.60e-05473223201973
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19

2.60e-0547327983737
Pubmed

The DNA sequence and biology of human chromosome 19.

MAG ERVK-6 PRPF31 AURKC GPX4 ERVK-19

3.03e-0528473615057824
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MAG CACNB2 LONP1 SELENBP1 LARP1 DLG1 DLG3 PTGS2 ALDH7A1 AGTPBP1 MAPK8IP3 CASK

4.04e-051431731237142655
Pubmed

Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.

DLG1 DLG3

4.33e-05573211134026
Pubmed

Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney.

DLG1 CASK

4.33e-05573216105026
Pubmed

Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.

DLG1 DLG3

4.33e-05573212713445
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

4.33e-05573211401426
Pubmed

Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling.

PAK1 CRKL

4.33e-0557329851874
Pubmed

Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.

IFT140 CRKL

4.33e-05573223469164
Pubmed

SAP90 binds and clusters kainate receptors causing incomplete desensitization.

DLG1 DLG3

4.33e-0557329808460
Pubmed

A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.

PAK1 CRKL

4.33e-05573224886428
Pubmed

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.

LONP1 GTF2I GPX4 PTGS2

4.53e-059373427689697
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

PRPF31 LONP1 GTF2I LARP1 GIGYF1 GPATCH8 HUWE1 CASK

5.85e-0563973823443559
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ENDOD1 CACNB2 BMPR1B GTF2I EXOC6B LARP1 DLG1 HUWE1 INTS8 PRDM15 MAPK8IP3 CASK

5.93e-051489731228611215
Pubmed

Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.

DLG1 DLG3

6.48e-05673211572861
Pubmed

Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect.

DLG1 DLG3

6.48e-05673214529713
Pubmed

Macrophages are essential for the early wound healing response and the formation of a fibrovascular scar.

FLT1 STAT6

6.48e-05673223602833
Pubmed

Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

DLG1 DLG3

6.48e-05673219118189
Pubmed

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers.

FZD4 DLG1

6.48e-05673231066677
Pubmed

Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.

DLG1 DLG3

6.48e-05673212070168
Pubmed

Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms.

FLT1 PTGS2

6.48e-05673218627789
Pubmed

Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.

DLG1 DLG3

6.48e-05673211274188
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19

6.48e-05673215063128
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PAK1 DLG1 ALAD HUWE1 INTS8 AGTPBP1 USP33 CNOT8 MAPK8IP3 STAT6 CASK

7.31e-051285731135914814
Pubmed

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

MAG DLG1 DLG3 ALAD CLSTN1 CRKL

8.33e-0534173629791485
Pubmed

A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.

DLG3 CASK

9.06e-0577329753324
Pubmed

SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.

DLG1 DLG3

9.06e-0577329115257
Pubmed

p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.

DLG1 CASK

9.06e-05773215729360
Pubmed

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.

MAG PAK1

9.06e-05773227583434
Pubmed

Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.

DLG1 DLG3

9.06e-05773211997254
Pubmed

A novel family of adhesion-like molecules that interacts with the NMDA receptor.

DLG1 DLG3

9.06e-05773216495444
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

BMPR1B MEX3A LARP1 DLG1 HUWE1 CASK

1.09e-0435873632460013
Pubmed

Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

LARP1 ALDH7A1 CNOT8

1.18e-044573323663784
Pubmed

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.

DLG1 DLG3

1.21e-04873223397623
Pubmed

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.

LARP1 UNC45A CRKL

1.26e-044673334265304
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

PRPF31 MEX3A LARP1 DLG1 GPATCH8 HUWE1 AGTPBP1 USP33

1.51e-0473373834672954
Pubmed

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.

FLT1 PAK1 CRKL

1.52e-044973323397142
Pubmed

Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.

FZD4 DLG1

1.55e-04973212067714
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

1.93e-041073212970426
Pubmed

A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.

DLG1 CASK

1.93e-041073214960569
Pubmed

Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA.

IFT140 MAPK8IP3

1.93e-041073210899141
Pubmed

Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

FLT1 GPX4 PTGS2 STAT6

2.27e-0414173418636124
Pubmed

DGKι regulates presynaptic release during mGluR-dependent LTD.

DLG1 DLG3

2.36e-041173221119615
Pubmed

Genomic analysis of mouse retinal development.

FZD4 COQ10A ENDOD1 CACNB2 RNASEH2C GPX4 UNC45A CLSTN1 USP33

2.53e-04100673915226823
Pubmed

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

TMEM106B GTF2I CTSD CRKL

2.80e-0414973426370502
Pubmed

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.

CIB3 PCDH15

2.83e-041273228663585
Pubmed

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.

ARHGAP15 PAK1

2.83e-041273233251042
Pubmed

NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.

DLG1 DLG3

2.83e-041273216980967
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

MAG GPX4 LARP1 DLG1 DLG3 CASK

2.92e-0443073632581705
Pubmed

A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.

PRPF31 GTF2I

3.34e-041373237408008
Pubmed

A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.

DLG1 CASK

3.34e-041373215673434
Pubmed

The DNA sequence of human chromosome 7.

ERVK-6 TMEM106B GTF2I STK17A CYP3A43 SGCE

3.34e-0444173612853948
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHGB5 PCDHGB4 PCDHGA8

4.03e-046873311230163
Pubmed

Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.

PCDHGB5 PCDHGB4

4.48e-041573223515096
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

ALDH4A1 ADH1B

4.48e-04157329726281
Pubmed

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.

LARP1 CNOT8

4.48e-041573231366290
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

CACNB2 BMPR1B PCDH15 DLG1

4.71e-0417173420201926
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHGB5 PCDHGB4 PCDHGA8

4.77e-047273310380929
Pubmed

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

SELENBP1 GPX4 TERT PTGS2

4.82e-0417273420628624
Pubmed

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

DLG1 DLG3

5.12e-041673221920314
Cytoband5q31

PCDHGB5 PCDHGB4 PCDHGA8 ALDH7A1

3.37e-051157245q31
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

CACNB2 DLG1 DLG3 CASK

4.81e-0726454904
GeneFamilyClustered protocadherins

PCDHGB5 PCDHGB4 PCDHGA8

5.40e-046445320
GeneFamilyCadherin related

PCDH15 CLSTN1

8.04e-041745224
GeneFamilyAldehyde dehydrogenases

ALDH4A1 ALDH7A1

1.01e-0319452398
Diseasenephroblastoma (is_marker_for)

FLT1 PAK1 TERT PTGS2

1.20e-0634694DOID:2154 (is_marker_for)
DiseaseSarcomatoid Renal Cell Carcinoma

FLT1 PAK1 ALAD CTSD PTGS2

1.28e-05128695C1266043
DiseaseChromophobe Renal Cell Carcinoma

FLT1 PAK1 ALAD CTSD PTGS2

1.28e-05128695C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

FLT1 PAK1 ALAD CTSD PTGS2

1.28e-05128695C1266044
DiseasePapillary Renal Cell Carcinoma

FLT1 PAK1 ALAD CTSD PTGS2

1.28e-05128695C1306837
DiseaseRenal Cell Carcinoma

FLT1 PAK1 ALAD CTSD PTGS2

1.28e-05128695C0007134
Diseasemelanoma

FLT1 SLC15A2 PAK1 MAP3K9 TERT PTGS2

2.55e-05248696C0025202
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

FLT1 PAK1 ALAD CTSD PTGS2

2.57e-05148695C0279702
Diseasemental development measurement

PCDHGB5 PCDHGB4 PCDHGA8

2.71e-0525693EFO_0008230
Diseaseprostate carcinoma in situ (is_marker_for)

FZD4 FLT1 PTGS2

3.84e-0528693DOID:8634 (is_marker_for)
DiseaseKidney Diseases

ALAD CTSD TERT PTGS2

5.51e-0588694C0022658
Diseaseleiomyosarcoma (is_marker_for)

FLT1 TERT

8.03e-056692DOID:1967 (is_marker_for)
Diseaseductal carcinoma in situ (is_marker_for)

FLT1 TERT PTGS2

1.05e-0439693DOID:0060074 (is_marker_for)
DiseaseCleft palate, isolated

FZD4 DLG1 CASK

1.32e-0442693C1837218
Diseasecervix uteri carcinoma in situ (is_marker_for)

DLG1 TERT PTGS2

1.32e-0442693DOID:8991 (is_marker_for)
Diseasesyndromic X-linked intellectual disability (implicated_via_orthology)

HUWE1 CASK

1.50e-048692DOID:0060309 (implicated_via_orthology)
Diseasebenign neoplasm (implicated_via_orthology)

DLG1 DLG3

1.50e-048692DOID:0060072 (implicated_via_orthology)
Diseaseidiopathic pulmonary fibrosis (is_implicated_in)

TERT PTGS2

1.92e-049692DOID:0050156 (is_implicated_in)
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

DLG1 DLG3 GIGYF1

2.09e-0449693DOID:0060037 (implicated_via_orthology)
DiseaseColorectal Carcinoma

FZD4 CACNB2 SELENBP1 GPX4 DLG3 PTGS2 AGTPBP1 ADH1B

2.30e-04702698C0009402
Diseaserenal cell carcinoma (is_marker_for)

FLT1 PAK1 TERT PTGS2

2.35e-04128694DOID:4450 (is_marker_for)
DiseaseLibman-Sacks Disease

TERT PTGS2 BANK1

3.44e-0458693C0242380
DiseaseDiverticular Bleeding

BMPR1B ARHGAP15

4.13e-0413692C4505353
DiseaseMental Retardation, X-Linked Nonsyndromic

DLG3 HUWE1

4.13e-0413692C3501611
DiseaseDiverticular Diseases

BMPR1B ARHGAP15

4.13e-0413692C4317009
Diseasetransitional cell carcinoma (is_marker_for)

PAK1 TERT PTGS2

4.40e-0463693DOID:2671 (is_marker_for)
Diseasecarcinoma (implicated_via_orthology)

FLT1 DLG1 DLG3

4.60e-0464693DOID:305 (implicated_via_orthology)
Diseasemean platelet volume

ENDOD1 ARHGAP15 PCDHGB5 PCDHGB4 DLG3 TERT PCDHGA8 BANK1 CRKL

6.00e-041020699EFO_0004584
DiseaseLupus Erythematosus, Systemic

TERT PTGS2 BANK1

6.24e-0471693C0024141
Diseasechildhood trauma measurement, alcohol consumption measurement

PCDHGB5 PCDHGB4 PCDHGA8

6.24e-0471693EFO_0007878, EFO_0007979
DiseaseCannabis use, age at onset

PCDHGB4 LARP1

8.98e-0419692EFO_0004847, EFO_0007585
Diseasehydrocephalus (implicated_via_orthology)

STK36 CCDC39

8.98e-0419692DOID:10908 (implicated_via_orthology)
DiseaseCleft Palate

FZD4 DLG1 CASK

9.16e-0481693C0008925
DiseaseSarcosine measurement

PCDHGB4 PCDHGA8

1.32e-0323692EFO_0021668
Diseasealcohol use disorder measurement, alcohol consumption measurement

ARHGAP15 PCDH15 ADH1B

1.54e-0397693EFO_0007878, EFO_0009458
DiseaseDisorder of eye

FZD4 PRPF31 PCDH15 CTSD

1.55e-03212694C0015397
Diseasealcohol use disorder measurement

CACNB2 ARHGAP15 BANK1 ADH1B

1.61e-03214694EFO_0009458
DiseaseEdema

PTGS2 STAT6

1.69e-0326692C0013604
DiseaseAnasarca

PTGS2 STAT6

1.69e-0326692C0151603
Diseaseretinitis pigmentosa (implicated_via_orthology)

PRPF31 AGTPBP1

1.82e-0327692DOID:10584 (implicated_via_orthology)
Diseasegastric adenocarcinoma (is_marker_for)

GPX4 STAT6

1.96e-0328692DOID:3717 (is_marker_for)
DiseaseMental Retardation, X-Linked

DLG3 CASK

2.10e-0329692C1136249

Protein segments in the cluster

PeptideGeneStartEntry
APPGNTKDIIMIYEE

BANK1

21

Q8NDB2
LPPEMIEGRTYDEKV

AURKC

206

Q9UQB9
PYMLVVGNIVIKPDS

ERVK-19

386

O71037
PYMLVVGNIVIKPDS

ERVK-8

386

Q902F8
VMDRPGNYVEPTIVT

ALDH7A1

401

P49419
PPKAYEVRIKMVAVG

ADH1B

31

P00325
VNYTRPVIILGPMKD

DLG1

711

Q12959
EPIMKEEIFGPVLSV

ALDH4A1

441

P30038
VDGYVMVLQPEEPKI

CLSTN1

641

O94985
RVGTKRYMPPEVLDE

BMPR1B

371

O00238
YIFKIVPMLNPDGVI

AGTPBP1

951

Q9UPW5
MRPVVLVGPSLKGYE

CACNB2

281

Q08289
RYEILTVVMLPPEGE

CCDC39

641

Q9UFE4
GKIPRDMYEDELVPV

RBM46

66

Q8TBY0
VPPDVYTDQVIKRMI

INTS8

871

Q75QN2
IYRVKVLENMPPGTR

PCDHGA8

246

Q9Y5G5
EQIRYRIPEEMPKGS

PCDHGB4

31

Q9UN71
MAPEVVKREPYGKPV

CASK

186

O14936
YPVVKEGRTLDAKMP

LARP1

801

Q6PKG0
VKYPPVIVEMNSSVE

MAG

236

P20916
VPMAVAILKEVESPY

GIGYF1

921

O75420
VPVYCRPLVEKDPTM

MAPK8IP3

691

Q9UPT6
VKPGMPYLDIVREVK

ALAD

251

P13716
PVYTMGAIPIVCKDI

ENDOD1

441

O94919
RTDPIPIVVKYDVMG

GPATCH8

66

Q9UKJ3
DPVAYRIEPMVVPGV

DDHD2

541

O94830
QIIDGEMYPPTVKDT

PTGS2

241

P35354
FTVERMYDVTPPGVV

LONP1

751

P36776
PIPVTSEEMYKKVVG

EXOC6B

456

Q9Y2D4
EQIRYRIPEEMPKGS

PCDHGB5

31

Q9Y5G0
KDGRVGMIPVPYVEK

CRKL

166

P46109
VGTEERIPIPLMDYI

HUWE1

756

Q7Z6Z7
PYMLVVGNIVIKPDS

ERVK-7

1146

P63135
PVLKVGVAMRFSPVE

ITGAD

616

Q13349
MAPEVVTRKAYGPKV

PAK1

431

Q13153
TVTVIVKDMNDYPPV

PCDH15

911

Q96QU1
VYVPMCTEKINIPIG

FZD4

101

Q9ULV1
VFIPKGLAVMVPIYA

CYP3A43

386

Q9HB55
PYMLVVGNIVIKPDS

ERVK-25

386

P61570
PYMLVVGNIVIKPDS

ERVK-6

386

Q69384
AVTEGPIPEVLKNYM

CTSD

61

P07339
KAQLEVGFPPVMERY

COQ10A

131

Q96MF6
YARPVIILGPMKDRV

DLG3

626

Q92796
YIAMDTEFPGVVVRP

CNOT8

36

Q9UFF9
PYMLVVGNIVIKPDS

HERVK_113

386

Q902F9
VVKRYGPMEEPLVIE

GPX4

176

P36969
STVVPVPYEKMLRDQ

GTF2I

131

P78347
YVPVKTEDMRGPADK

SLC15A2

696

Q16348
LYTVPPEGKAEEVMK

IFT140

256

Q96RY7
EIVVYEMPVSPVEAP

MAP3K9

856

P80192
EVIPMAYVPVSRAVS

RPIA

216

P49247
PRYSVLIMAEKPVGD

PTGFRN

581

Q9P2B2
IIGPLDMKQIDYTVP

TMEM106B

186

Q9NUM4
PITVAEYMKEVLTNP

NDUFAF7

56

Q7L592
PELGPVVMVKDSFVL

PRDM15

326

P57071
VIPPLEQLMVEKEGY

ARHGAP15

71

Q53QZ3
RGEAVVRVAMYAPPE

SPPL2C

166

Q8IUH8
LEAMKGPREEIVYLP

SELENBP1

16

Q13228
EPGPYMDVVVSLVTI

PI4KAP2

516

A4QPH2
VPLPINDLKEGVYVM

SGCE

211

O43556
KGTPLYMSPELVEER

STK36

161

Q9NRP7
REIMGTPEYVAPEIL

STK17A

221

Q9UEE5
DVKVPYELIGSMPEL

CIB3

51

Q96Q77
IKTPVRGEEPVFMVT

MEX3A

166

A1L020
YVPATIKMTVERDQP

STAT6

641

P42226
MGPVEAAPEYRVIVD

PRPF31

81

Q8WWY3
PPGLVGYVMVTEEKK

RNASEH2C

76

Q8TDP1
FVPIYIKAGVVTMPE

SLC5A1

116

P13866
TGRPFVEMYSEIPEI

FLT1

131

P17948
KPDGLRPIVNMDYVV

TERT

626

O14746
PEMTFPGERIYEVVR

UNC45A

721

Q9H3U1
VGEPIMYPEINRFLK

TYW1B

421

Q6NUM6
VPPRKAGYIEDLVLM

USP33

771

Q8TEY7
MTVPPRRVGVFLDYE

TRIM6

426

Q9C030