Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

1.52e-07459288GO:0005216
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

2.82e-07102285GO:0005249
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCU

3.60e-07343287GO:0005261
GeneOntologyMolecularFunctionchannel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

4.23e-07525288GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

4.29e-07526288GO:0022803
GeneOntologyMolecularFunctionpotassium channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

8.74e-07128285GO:0005267
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

2.04e-06152285GO:0022843
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

3.24e-06167285GO:0015079
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

4.94e-06182285GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

5.21e-06184285GO:0022832
GeneOntologyMolecularFunctiongated channel activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2

5.78e-06334286GO:0022836
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNG2 KCNS1 KCNS3

7.90e-0628283GO:0005251
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

9.15e-06793288GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCU

2.80e-05664287GO:0008324
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCU

3.76e-05465286GO:0046873
GeneOntologyMolecularFunctionpotassium channel regulator activity

KCNV1 KCNS1 KCNS3

6.87e-0557283GO:0015459
GeneOntologyMolecularFunctionion channel regulator activity

KCNV1 KCNS1 KCNS3 MCUB

7.34e-05162284GO:0099106
GeneOntologyMolecularFunctionchannel regulator activity

KCNV1 KCNS1 KCNS3 MCUB

9.68e-05174284GO:0016247
GeneOntologyMolecularFunctiontransporter regulator activity

KCNV1 KCNS1 KCNS3 MCUB

1.03e-04177284GO:0141108
GeneOntologyMolecularFunctiontransmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

1.56e-041180288GO:0022857
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCU

1.95e-04627286GO:0022890
GeneOntologyMolecularFunctiontransporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

2.86e-041289288GO:0005215
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCU

5.40e-04758286GO:0015318
GeneOntologyMolecularFunctionion channel inhibitor activity

KCNV1 MCUB

2.06e-0348282GO:0008200
GeneOntologyMolecularFunctionchannel inhibitor activity

KCNV1 MCUB

2.23e-0350282GO:0016248
GeneOntologyMolecularFunctiontransporter inhibitor activity

KCNV1 MCUB

2.32e-0351282GO:0141110
GeneOntologyBiologicalProcessregulation of membrane potential

KCNV1 FZD9 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 BAD

5.33e-07559288GO:0042391
GeneOntologyBiologicalProcessprotein complex oligomerization

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCU

2.40e-06296286GO:0051259
GeneOntologyBiologicalProcessaction potential

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

6.85e-06201285GO:0001508
GeneOntologyBiologicalProcessprotein homooligomerization

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.16e-05224285GO:0051260
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.37e-05232285GO:0071805
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

2.52e-05942288GO:0098655
GeneOntologyBiologicalProcesspotassium ion transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

2.95e-05272285GO:0006813
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

8.37e-051115288GO:0034220
GeneOntologyBiologicalProcessmonoatomic cation transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

1.08e-041157288GO:0006812
GeneOntologyBiologicalProcessmitochondrial transport

FZD9 MCUB MCU BAD

1.61e-04205284GO:0006839
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

1.81e-04922287GO:0098662
GeneOntologyBiologicalProcesscalcium import into the mitochondrion

MCUB MCU

2.68e-0418282GO:0036444
GeneOntologyBiologicalProcessmetal ion transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

2.98e-041000287GO:0030001
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

3.30e-041017287GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transport

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 PIEZO2 MCUB MCU

3.55e-041374288GO:0006811
GeneOntologyBiologicalProcessregulation of delayed rectifier potassium channel activity

KCNS1 KCNS2

3.67e-0421282GO:1902259
GeneOntologyBiologicalProcessmitochondrial calcium ion transmembrane transport

MCUB MCU

5.23e-0425282GO:0006851
GeneOntologyBiologicalProcessmitochondrial calcium ion homeostasis

MCUB MCU

7.05e-0429282GO:0051560
GeneOntologyBiologicalProcesspositive regulation of peptide hormone secretion

FGG MCU BAD

1.23e-03157283GO:0090277
GeneOntologyBiologicalProcesspositive regulation of peptide secretion

FGG MCU BAD

1.32e-03161283GO:0002793
GeneOntologyBiologicalProcessregulation of mitochondrion organization

FZD9 MCU BAD

1.35e-03162283GO:0010821
GeneOntologyCellularComponentcation channel complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

2.62e-08235297GO:0034703
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.53e-0791295GO:0008076
GeneOntologyCellularComponentpotassium channel complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

2.99e-07104295GO:0034705
GeneOntologyCellularComponentmonoatomic ion channel complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

6.62e-07378297GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

5.70e-06523297GO:1902495
GeneOntologyCellularComponenttransporter complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

7.93e-06550297GO:1990351
GeneOntologyCellularComponentuniplex complex

MCUB MCU

2.78e-056292GO:1990246
GeneOntologyCellularComponentmembrane protein complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 MCUB MCU

3.68e-031498297GO:0098796
GeneOntologyCellularComponentplasma membrane protein complex

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

4.14e-03785295GO:0098797
GeneOntologyCellularComponentcalcium channel complex

MCUB MCU

4.59e-0373292GO:0034704
HumanPhenoHyperlordosis

TMEM270 PIEZO2 RAB3GAP2 DNMT3B

4.92e-0522264HP:0003307
HumanPhenoLordosis

TMEM270 PIEZO2 RAB3GAP2 DNMT3B

4.92e-0522264HP:0002939
DomainK_chnl_volt-dep_Kv

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

3.37e-1027275IPR003968
DomainVG_K_chnl

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

9.85e-1033275IPR028325
DomainBTB_2

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.17e-0853275PF02214
DomainT1-type_BTB

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.17e-0853275IPR003131
DomainChannel_four-helix_dom

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.70e-0857275IPR027359
Domain-

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.70e-08572751.20.120.350
DomainK_chnl_volt-dep_Kv9

KCNS1 KCNS2 KCNS3

9.39e-087273IPR003971
DomainIon_trans_dom

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

5.62e-07114275IPR005821
DomainIon_trans

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

5.62e-07114275PF00520
DomainMCU

MCUB MCU

2.01e-062272PF04678
DomainCoiled-coil-dom_prot_109_C

MCUB MCU

2.01e-062272IPR006769
DomainBTB

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

5.35e-06180275SM00225
DomainBTB/POZ_dom

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

6.11e-06185275IPR000210
DomainSKP1/BTB/POZ

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

6.78e-06189275IPR011333
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

4.11e-0941225MM14546
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

5.26e-0943225M1056
PathwayREACTOME_POTASSIUM_CHANNELS

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

3.51e-0798225MM14545
PathwayREACTOME_POTASSIUM_CHANNELS

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

4.51e-07103225M1073
PathwayREACTOME_NEURONAL_SYSTEM

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.39e-04335225MM14503
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

FGG MCUB MCU

1.99e-0474223M48080
PathwayREACTOME_PROCESSING_OF_SMDT1

MCUB MCU

2.75e-0416222M27819
PathwayREACTOME_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT

MCUB MCU

3.12e-0417222MM15541
PathwayREACTOME_NEURONAL_SYSTEM

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

3.59e-04411225M735
PathwayWP_7Q1123_COPY_NUMBER_VARIATION_SYNDROME

FZD9 TMEM270 WNT2

5.74e-04106223M40052
PathwayREACTOME_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT

MCUB MCU

5.77e-0423222M27816
PathwayWP_ALZHEIMERS_DISEASE

FZD9 WNT2 MCU BAD

6.46e-04261224M42565
PathwayPID_WNT_SIGNALING_PATHWAY

FZD9 WNT2

8.57e-0428222M77
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

KCNG2 KCNS3

1.12e-0332222MM14983
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD9 WNT2

1.42e-0336222M39699
PathwayWP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS

FZD9 WNT2 MCU BAD

1.48e-03326224M39379
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

KCNG2 KCNS3

1.93e-0342222M791
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD9 WNT2

2.11e-0344222MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD9 WNT2

2.21e-0345222M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD9 WNT2

2.31e-0346222M47409
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.81e-104029516382104
Pubmed

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.

MCUB MCU

6.71e-07229223900286
Pubmed

MCUb Induction Protects the Heart From Postischemic Remodeling.

MCUB MCU

6.71e-07229232299299
Pubmed

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling.

MCUB MCU

6.71e-07229226828201
Pubmed

piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.

SOAT1 DNMT3B

6.71e-07229235354120
Pubmed

New modulatory alpha subunits for mammalian Shab K+ channels.

KCNS1 KCNS2

6.71e-0722929305895
Pubmed

Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9.

FZD9 WNT2

2.01e-06329228665975
Pubmed

MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.

MCUB MCU

2.01e-06329237976157
Pubmed

Electrically silent potassium channel subunits from human lens epithelium.

KCNS1 KCNS3

2.01e-06329210484328
Pubmed

MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.

MCUB MCU

4.02e-06429238514795
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNV1 KCNS1 KCNS2 KCNS3

5.37e-0613929416985003
Pubmed

Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.

FZD9 WNT2

6.70e-06529212138115
Pubmed

EMRE is an essential component of the mitochondrial calcium uniporter complex.

MCUB MCU

6.70e-06529224231807
Pubmed

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.

MCUB MCU

6.70e-06529231533452
Pubmed

GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.

SEMA3C WNT2

1.00e-05629219666519
Pubmed

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.

FZD9 WNT2

2.41e-05929219038973
Pubmed

Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.

MCUB MCU

3.01e-051029235302860
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

FZD9 SEMA3C LRRC4C

1.27e-0411729317145500
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD9 WNT2

1.53e-042229217064353
Pubmed

Dysregulation of TBX1 dosage in the anterior heart field results in congenital heart disease resembling the 22q11.2 duplication syndrome.

SEMA3C WNT2

1.99e-042529229509905
Pubmed

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.

FZD9 WNT2

2.33e-042729217804636
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD9 WNT2

2.69e-042929218364260
Pubmed

Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.

SEMA3C WNT2

2.88e-043029228346476
Pubmed

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.

SEMA3C WNT2

3.08e-043129225053429
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

KCNV1 KCNS1 KCNS2 ACSM3 BAD

3.14e-0473029534857952
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD9 WNT2

4.16e-043629224151333
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

FZD9 WNT2

4.39e-043729235831952
Pubmed

Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.

FGG CTSO

4.39e-043729216707424
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

FZD9 WNT2

4.39e-043729215342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

FZD9 WNT2

4.39e-043729218800919
Pubmed

USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.

SOAT1 MCU

4.39e-043729232133736
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

FZD9 WNT2

4.63e-043829218635608
Pubmed

Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.

FZD9 TMEM270

4.63e-043829211779826
Pubmed

Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.

FZD9 WNT2

4.63e-043829221041481
Pubmed

AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity.

SEMA3C WNT2

5.13e-044029224680892
Pubmed

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

FZD9 WNT2

7.09e-044729228813421
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD9 WNT2

7.09e-044729233141892
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

FZD9 WNT2

7.09e-044729218351675
Pubmed

Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.

FZD9 WNT2

7.71e-044929219562671
InteractionKCNB1 interactions

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

3.30e-0943285int:KCNB1
InteractionKCNS2 interactions

KCNV1 KCNS1 KCNS2

8.65e-0714283int:KCNS2
InteractionFZD9 interactions

FZD9 WNT2

5.19e-058282int:FZD9
InteractionKCNV1 interactions

KCNV1 KCNS2

6.66e-059282int:KCNV1
InteractionKCNS1 interactions

KCNS1 KCNS2

8.32e-0510282int:KCNS1
Cytoband7q11.23

FZD9 TMEM270

1.73e-03972927q11.23
CytobandEnsembl 112 genes in cytogenetic band chr4q32

FGG CTSO

2.63e-03120292chr4q32
GeneFamilyPotassium voltage-gated channels

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

4.65e-1040195274
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

SEMA3C LRRC4C

1.22e-02161192593
GeneFamilyEndogenous ligands

FGG WNT2

2.53e-02237192542
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNG2 KCNS3 SEMA3C FGG

9.81e-071172940602bbad908cb28c5093b74d717da5f2af577943
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-5|TCGA-Stomach / Sample_Type by Project: Shred V9

KCNV1 ERVMER34-1 DNMT3B

6.59e-05121293392700c5032b83d4d4e191fea9bcd170e4567b9d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Krt73|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNS3 SEMA3C PIEZO2

8.34e-051312939ca209a8652aae603c4a867ea06b06ac51e7d189
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-4|TCGA-Brain / Sample_Type by Project: Shred V9

KCNV1 KCNS1 KCNS2

1.15e-04146293632f52780607c638b5d3dd3fb9251c719f162a35
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

KCNV1 KCNG2 WNT2

1.17e-041472938f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-4|TCGA-Brain / Sample_Type by Project: Shred V9

KCNV1 KCNS1 KCNS2

1.22e-04149293ff472ad641efd655905e99a9a4cacd5245ab8854
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KCNV1 KCNS1 KCNS2

1.51e-04160293f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KCNV1 KCNS1 KCNS2

1.53e-04161293ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell3'_v3-bone_marrow-Lymphocytic_B-Pre-B|bone_marrow / Manually curated celltypes from each tissue

ACSM3 ZNF606 DNMT3B

1.56e-04162293e088e66aabc307dde5d2b9aa295c34ef68155b1a
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)|Hippocampus / BrainAtlas - Mouse McCarroll V32

KCNV1 KCNG2 WNT2

1.74e-041682936db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCellsevere-Myeloid-Eosinophils|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SEMA3C ASRGL1 ACSM3

1.80e-04170293863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCellIonocyte-iono-2|World / Class top

KCNS3 ACSM3 SOAT1

1.90e-04173293e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD9 MCUB DNMT3B

1.90e-041732935d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNV1 KCNG2 LNX2

1.96e-0417529306af6629766e2054e6995e8cdb3907658fec49d3
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FZD9 KCNG2 PIEZO2

2.03e-04177293b1775e05c28883a15c56628028770bc59d3233fb
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

KCNS3 SEMA3C LRRC4C

2.06e-04178293d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

KCNS3 SEMA3C LRRC4C

2.06e-04178293611504b0a9e6318b18fba83787b03f9245c82252
ToppCellfacs-SCAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3C MCUB WNT2

2.13e-041802936c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg|bone_marrow / Manually curated celltypes from each tissue

PIEZO2 ERVMER34-1 DNMT3B

2.13e-0418029344ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3C MCUB WNT2

2.38e-041872937beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PIEZO2 ZNF606 MCUB

2.42e-0418829388b808561ebde997ac8a8bbd1d9bbda49bbb6646
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PIEZO2 ACSM3 DNMT3B

2.46e-0418929356156325cc36b1329bf483f81bb74f371ef15e20
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

KCNS3 PIEZO2 WNT2

2.50e-0419029371e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-OPC_related-OPC|GW16 / Sample Type, Dataset, Time_group, and Cell type.

KCNS3 LRRC4C CTSO

2.58e-041922935d9bc234f01c73b2531edf8960588d5b6cf260a7
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

LNX2 ASRGL1 LRRC4C

2.58e-04192293cc9911e182a289779a2612bc213daae5607689e7
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-OPC_related|GW16 / Sample Type, Dataset, Time_group, and Cell type.

KCNS3 LRRC4C CTSO

2.58e-04192293e6d115143ced6a0d9fe7c98acd3f730bac83f66b
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3C MCUB WNT2

2.62e-0419329380380358f44c2f4781676ec0f1fa94d4c69080d6
ToppCellMesenchymal_cells-Endosteal_fibro.|Mesenchymal_cells / Lineage and Cell class

SEMA3C MCUB WNT2

2.66e-041942939a4b5de4d1d8a0aa76fed7b36548ea628f3009cc
ToppCell(5)_Fibroblast-C_(Myofibroblast)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

KCNS3 PIEZO2 WNT2

2.66e-0419429329a72e565c19407bbd198cfbc2a78106fe830d05
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KCNS3 SEMA3C LRRC4C

2.66e-04194293c992e3357f4bf3069f8d697803e5785e49a2ef0a
ToppCellIPF-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

SEMA3C MCUB SOAT1

2.66e-04194293da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCellMesenchymal_cells-Endosteal_fibro.|World / Lineage and Cell class

SEMA3C MCUB WNT2

2.70e-04195293d53974d1866e23c894ffd492ea11d20422919b11
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3C MCUB WNT2

2.70e-04195293d663d54a4bcc94e2c9b50ed931e2b2db4ca41373
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNV1 KCNS1 KCNS2

2.70e-04195293ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

KCNS3 PIEZO2 WNT2

2.74e-041962936730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SEMA3C LRRC4C WNT2

2.74e-04196293ee45e4de9d706ec87094e87f47d3e514539b8092
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SEMA3C LRRC4C WNT2

2.74e-04196293fa4a85a3cd52df0da5dfedc0e584e9df8c61ce89
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

KCNS3 PIEZO2 WNT2

2.74e-0419629321dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell368C-Fibroblasts-Fibroblast-G-|368C / Donor, Lineage, Cell class and subclass (all cells)

KCNS3 PIEZO2 WNT2

2.78e-04197293d5d9263451f6c10cb3b9c17740183ca334e24851
ToppCell368C-Fibroblasts-Fibroblast-G|368C / Donor, Lineage, Cell class and subclass (all cells)

KCNS3 PIEZO2 WNT2

2.78e-04197293156155c2f0c1a2461e45803da578af18ee221660
ToppCellControl-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

SEMA3C MCUB SOAT1

2.78e-0419729364cc5f61c88e9560b0f8f6f3151255dffb5c3d66
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|normal_Lung / Location, Cell class and cell subclass

KCNS3 PIEZO2 WNT2

2.78e-041972936c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

KCNS3 PIEZO2 WNT2

2.82e-04198293a9afedbc0556faf4a46f7bf28f4a9adb3bc859d8
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

KCNS3 PIEZO2 WNT2

2.82e-04198293e0e47cf65774191981840b22905b2094b95abe0f
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

KCNS3 PIEZO2 WNT2

2.82e-041982937b5350768f306ec528e271d2ac4470bf668ec6f0
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNS3 PIEZO2 WNT2

2.86e-041992937f4840ae6a888380feca722543e5e52783f3e35d
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNS3 PIEZO2 WNT2

2.86e-04199293fb23ecce41e31e2cc01814e3c0add756f489561f
ToppCellCOVID-19-COVID-19_Mild-Others-HSPC|COVID-19_Mild / Disease, condition lineage and cell class

SEMA3C ACSM3 DNMT3B

2.86e-041992930230103c37ae3aff58240739b89f2c36b1e39a69
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNS3 PIEZO2 WNT2

2.86e-04199293301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCellproximal-mesenchymal-Alveolar_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNS3 PIEZO2 WNT2

2.86e-041992939a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCelldistal-mesenchymal-Alveolar_Fibroblast|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNS3 PIEZO2 WNT2

2.86e-04199293655d07cf9a2fd9b945a2ed4f824cba0297de72a8
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KCNS3 PIEZO2 WNT2

2.90e-04200293cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial-Glia_progenitor_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

KCNS3 LRRC4C CTSO

2.90e-042002936c1b7b0f3cd35d8cfee181ea83c73127dbc41ac5
ToppCelldistal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCNS3 PIEZO2 WNT2

2.90e-0420029320112be28f80baffad92641c9cfd7c3718967dbb
Drugpyraclofos

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3

1.79e-07106285CID000093460
Drugdiazoxide

KCNV1 KCNG2 KCNS1 KCNS2 KCNS3 BAD

2.88e-07227286CID000003019
DrugIndapamide [26807-65-8]; Up 200; 10.6uM; HL60; HT_HG-U133A

KCNS1 SEMA3C ACSM3 ZNF606 CTSO

3.85e-061972852361_UP
Diseasebehavior or behavioral disorder measurement, personality trait

KCNS3 LRRC4C

1.13e-0418262EFO_0004365, EFO_0004782
DiseaseCCL24 measurement

TMEM270 SEMA3C

1.71e-0422262EFO_0009418
Diseasecentral nervous system cancer

PIEZO2 LRRC4C

3.42e-0431262EFO_0000326
Diseasecortical surface area measurement

FZD9 KCNS3 SEMA3C CTSO RAB3GAP2 SOAT1

9.30e-041345266EFO_0010736
Diseasestem Cell Growth Factor beta measurement

KCNS3 PIEZO2

1.99e-0375262EFO_0008292
Diseasevisual epilepsy (biomarker_via_orthology)

WNT2 BAD

2.85e-0390262DOID:11832 (biomarker_via_orthology)
DiseaseIschemic stroke, coronary artery disease

KCNS3 SEMA3C

2.98e-0392262EFO_0001645, HP_0002140
Diseasesuntan

PIEZO2 DNMT3B

3.71e-03103262EFO_0004279
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

FZD9 MCUB

3.93e-03106262EFO_0008317, EFO_0008596
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement

FZD9 MCUB

4.15e-03109262EFO_0004639, EFO_0008317, EFO_0008596
Diseasefree cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

FZD9 MCUB

4.22e-03110262EFO_0008317, EFO_0008591, EFO_0008596
Diseaselifestyle measurement, alcohol consumption measurement

FZD9 PIEZO2

4.60e-03115262EFO_0007878, EFO_0010724
Diseaseglycine measurement

FGG GVINP1

6.47e-03137262EFO_0009767
Diseaselifestyle measurement, anxiety disorder measurement

FZD9 PIEZO2

6.47e-03137262EFO_0007795, EFO_0010724
Diseaseascending aortic diameter

TMEM270 PIEZO2

6.74e-03140262EFO_0021787
Diseaseamyotrophic lateral sclerosis

KCNG2 KCNS3

7.21e-03145262MONDO_0004976
Diseasetriglyceride measurement, phospholipid measurement

FZD9 MCUB

7.31e-03146262EFO_0004530, EFO_0004639
Diseaseobesity (biomarker_via_orthology)

FGG BAD

7.41e-03147262DOID:9970 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YAESPWALSNWMSWV

nan

501

Q9N2J8
FSWWPAMVVSWKATS

DNMT3B

236

Q9UBC3
MRQSSSWTRVFQSWW

BAD

141

Q92934
TGDWVAKWTSTSMPW

ASRGL1

271

Q7L266
WSITPDTSIQLYWKW

GVINP1

2366

Q7Z2Y8
YLWQYMPTWAWWITN

DHRS7

296

Q9Y394
TWDSQSVSPWWQQMR

RAB3GAP2

811

Q9H2M9
TLRWMQNFWATWTSV

KIAA0100

1281

Q14667
WSSTVTTNPEYWLMW

MDN1

3021

Q9NU22
AWLTWWVYSWDIMEP

MCUB

236

Q9NWR8
ARLTWWEYSWDIMEP

MCU

251

Q8NE86
VPASASTWWTYSGQW

ERVMER34-1

61

Q9H9K5
STWWTYSGQWMYERV

ERVMER34-1

66

Q9H9K5
EYDASWSPSWVMWLG

LNX2

576

Q8N448
FTSVPCAWWWATTSM

KCNV1

376

Q6PIU1
CAWWWATTSMTTVGY

KCNV1

381

Q6PIU1
VPASYWWAVISMTTV

KCNG2

356

Q9UJ96
IPACWWWATVSMTTV

KCNS2

361

Q9ULS6
NTIPACWWWGTVSMT

KCNS1

406

Q96KK3
SIPICWWWATISMTT

KCNS3

356

Q9BQ31
WWWATISMTTVGYGD

KCNS3

361

Q9BQ31
WLSWWIKDMAPSNTA

LRRC4C

311

Q9HCJ2
YSISSSNWWGWIRQP

IGHV4-28

46

A0A0C4DH34
NGIIWATWKTRWYSM

FGG

391

P02679
VWVWSSKTFQTWQSL

FZD9

526

O00144
FPTVVWTWWIMFLST

SOAT1

181

P35610
WTWWIMFLSTFSVPY

SOAT1

186

P35610
MVAVVTDKWSPWTWA

SEMA3C

666

Q99985
STPYWIVRNSWGSSW

CTSO

281

P43234
VMWNTSDTGWAKSAW

ACSM3

271

Q53FZ2
YWWVETMTALTSWHL

TMEM270

186

Q6UE05
LTWLTPEVNSSWWYM

WNT2

16

P09544
MDWVWTDTTLSLSSW

PIEZO2

2351

Q9H5I5
VSHMPPSWIQWWSTS

TMEM239

81

Q8WW34
QSWGMTAVDPWASWA

ZNF606

16

Q8WXB4