Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

PGA4 PGA5 PGA3

1.77e-0437593GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

PGA4 PGA5 PGA3

1.92e-0438593GO:0070001
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNA3 PLXNA1

5.56e-0412592GO:0017154
GeneOntologyBiologicalProcessvesicle cargo loading

CTAGE8 CTAGE15 CTAGE6 CTAGE4

3.80e-0636614GO:0035459
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

8.60e-062612GO:0021628
GeneOntologyBiologicalProcessregulation of axonogenesis

PLXNA3 MAP1B PAK2 PAK3 MACF1 PLXNA1

2.18e-05192616GO:0050770
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

2.58e-053612GO:0021627
GeneOntologyBiologicalProcessGolgi vesicle transport

NBAS USO1 CTAGE8 CTAGE15 MACF1 CTAGE6 CTAGE4

6.20e-05339617GO:0048193
GeneOntologyBiologicalProcessendoplasmic reticulum to Golgi vesicle-mediated transport

USO1 CTAGE8 CTAGE15 CTAGE6 CTAGE4

1.07e-04159615GO:0006888
GeneOntologyBiologicalProcessgonadotrophin-releasing hormone neuronal migration to the hypothalamus

PLXNA3 PLXNA1

1.79e-047612GO:0021828
GeneOntologyBiologicalProcesshypothalamic tangential migration using cell-axon interactions

PLXNA3 PLXNA1

1.79e-047612GO:0021856
GeneOntologyBiologicalProcessolfactory nerve development

PLXNA3 PLXNA1

2.38e-048612GO:0021553
GeneOntologyBiologicalProcesshypothalamus cell migration

PLXNA3 PLXNA1

3.06e-049612GO:0021855
GeneOntologyBiologicalProcesshypothalamus gonadotrophin-releasing hormone neuron differentiation

PLXNA3 PLXNA1

3.06e-049612GO:0021886
GeneOntologyBiologicalProcesshypothalamus gonadotrophin-releasing hormone neuron development

PLXNA3 PLXNA1

3.06e-049612GO:0021888
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

PLXNA3 MAP1B MACF1 PLXNA1

3.62e-04114614GO:0050772
GeneOntologyBiologicalProcesscranial nerve formation

PLXNA3 PLXNA1

4.65e-0411612GO:0021603
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

PLXNA3 MAP1B PAK3 MACF1 MME PLXNA1

6.14e-04354616GO:0050769
GeneOntologyCellularComponentmultivesicular body lumen

PGA4 PGA5 PGA3

8.62e-077623GO:0097486
GeneOntologyCellularComponentlate endosome lumen

PGA4 PGA5 PGA3

4.03e-0611623GO:0031906
GeneOntologyCellularComponentendoplasmic reticulum exit site

CTAGE8 CTAGE15 CTAGE6 CTAGE4

7.21e-0642624GO:0070971
GeneOntologyCellularComponentendosome lumen

PGA4 PGA5 PGA3

2.82e-0443623GO:0031904
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNA3 PLXNA1

6.61e-0413622GO:0002116
DomainAspartic_peptidase_N

PGA4 PGA5 PGA3

9.35e-077573IPR012848
DomainA1_Propeptide

PGA4 PGA5 PGA3

9.35e-077573PF07966
DomainAspartic_peptidase_A1

PGA4 PGA5 PGA3

3.19e-0610573IPR001461
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

3.19e-0610573IPR033121
DomainAsp

PGA4 PGA5 PGA3

3.19e-0610573PF00026
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

3.19e-0610573PS51767
Domain-

PGA4 PGA5 PGA3

5.81e-06125732.40.70.10
DomainASP_PROTEASE

PGA4 PGA5 PGA3

5.81e-0612573PS00141
DomainAspartic_peptidase_AS

PGA4 PGA5 PGA3

7.54e-0613573IPR001969
DomainPeptidase_aspartic_dom

PGA4 PGA5 PGA3

1.78e-0517573IPR021109
DomainPAK_BD

PAK2 PAK3

1.36e-046572IPR033923
DomainPlexin_cytopl

PLXNA3 PLXNA1

3.25e-049572PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

3.25e-049572IPR013548
DomainPlexin

PLXNA3 PLXNA1

3.25e-049572IPR031148
Domain-

HMCN1 EGFL6

4.94e-04115722.40.155.10
DomainGFP-like

HMCN1 EGFL6

4.94e-0411572IPR023413
Domain-

PAK2 PAK3

5.92e-04125723.90.810.10
DomainPBD

PAK2 PAK3

1.07e-0316572SM00285
DomainPBD

PAK2 PAK3

1.21e-0317572PF00786
DomainCRIB

PAK2 PAK3

1.68e-0320572PS50108
DomainCRIB_dom

PAK2 PAK3

1.85e-0321572IPR000095
DomainActinin_actin-bd_CS

SPTBN5 MACF1

2.22e-0323572IPR001589
DomainSpectrin

SPTBN5 MACF1

2.22e-0323572PF00435
DomainACTININ_2

SPTBN5 MACF1

2.22e-0323572PS00020
DomainACTININ_1

SPTBN5 MACF1

2.22e-0323572PS00019
DomainEGF_CA

SCUBE2 HMCN1 EGFL6

2.31e-0386573PF07645
DomaincEGF

SCUBE2 HMCN1

2.84e-0326572IPR026823
DomaincEGF

SCUBE2 HMCN1

2.84e-0326572PF12662
DomainIPT

PLXNA3 PLXNA1

3.06e-0327572SM00429
DomainEGF_Ca-bd_CS

SCUBE2 HMCN1 EGFL6

3.24e-0397573IPR018097
DomainEGF_CA

SCUBE2 HMCN1 EGFL6

3.44e-0399573PS01187
DomainVWF_A

INTS6L HMCN1 ANAPC1

3.44e-0399573IPR002035
DomainSpectrin_repeat

SPTBN5 MACF1

3.52e-0329572IPR002017
DomainASX_HYDROXYL

SCUBE2 HMCN1 EGFL6

3.53e-03100573PS00010
DomainTIG

PLXNA3 PLXNA1

4.02e-0331572PF01833
DomainSema

PLXNA3 PLXNA1

4.02e-0331572SM00630
DomainSemap_dom

PLXNA3 PLXNA1

4.02e-0331572IPR001627
DomainSema

PLXNA3 PLXNA1

4.02e-0331572PF01403
DomainSEMA

PLXNA3 PLXNA1

4.02e-0331572PS51004
DomainEGF-type_Asp/Asn_hydroxyl_site

SCUBE2 HMCN1 EGFL6

4.16e-03106573IPR000152
DomainPSI

PLXNA3 PLXNA1

4.28e-0332572PF01437
DomainSpectrin/alpha-actinin

SPTBN5 MACF1

4.28e-0332572IPR018159
DomainIPT

PLXNA3 PLXNA1

4.28e-0332572IPR002909
DomainPlexin_repeat

PLXNA3 PLXNA1

4.28e-0332572IPR002165
DomainSPEC

SPTBN5 MACF1

4.28e-0332572SM00150
DomainConA-like_dom

SEL1L3 FSD2 ADGRG4 EGFL6

4.47e-03219574IPR013320
DomainSerpin_dom

SERPINA12 SERPINA7

5.39e-0336572IPR023796
DomainSERPIN

SERPINA12 SERPINA7

5.69e-0337572SM00093
DomainSERPIN

SERPINA12 SERPINA7

5.69e-0337572PS00284
DomainSerpin

SERPINA12 SERPINA7

6.00e-0338572PF00079
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PAK2 PAK3 PLXNA1

6.67e-0814424MM15029
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PAK2 PAK3 PLXNA1

1.21e-0716424M16498
PathwayWP_GASTRIC_ACID_PRODUCTION

PGA4 PGA5 PGA3

3.99e-0611423M39726
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNA3 PAK2 PAK3 PLXNA1

1.54e-0551424MM14967
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNA3 PAK2 PAK3 PLXNA1

3.80e-0564424M7923
PathwayREACTOME_SURFACTANT_METABOLISM

PGA4 PGA5 PGA3

9.44e-0530423M27566
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1

3.08e-049422MM15030
PathwayREACTOME_CD28_DEPENDENT_VAV1_PATHWAY

PAK2 PAK3

5.61e-0412422M13618
PathwayREACTOME_CD28_DEPENDENT_VAV1_PATHWAY

PAK2 PAK3

5.61e-0412422MM14994
PathwayKEGG_AXON_GUIDANCE

PLXNA3 PAK2 PAK3 PLXNA1

5.72e-04129424M5539
PathwayREACTOME_ACTIVATION_OF_RAC1

PAK2 PAK3

6.62e-0413422M6322
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1

7.71e-0414422M7578
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1

8.88e-0415422MM15031
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PPP2R5C PAK2 PAK3

9.88e-0466423MM14990
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1

1.01e-0316422M8245
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

SPTBN5 PLXNA3 PAK2 PAK3 PLXNA1

1.02e-03261425MM15676
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

PAK2 PAK3

1.15e-0317422MM15215
PathwayREACTOME_EPHRIN_SIGNALING

PAK2 PAK3

1.29e-0318422MM15024
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PPP2R5C PAK2 PAK3

1.38e-0374423M17386
PathwayREACTOME_EPHRIN_SIGNALING

PAK2 PAK3

1.43e-0319422M27310
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

PAK2 PAK3

1.76e-0321422M27485
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PAKS

PAK2 PAK3

1.76e-0321422M27494
PathwayREACTOME_RHO_GTPASE_CYCLE

NOXA1 FAM169A PAK2 PAK3 DNMBP PLXNA1

1.79e-03439426MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

NOXA1 FAM169A PAK2 PAK3 DNMBP PLXNA1

2.02e-03450426M27078
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PAKS

PAK2 PAK3

2.11e-0323422MM15222
Pubmed

Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.

PGA4 PGA5 PGA3

5.39e-0936232032552
Pubmed

Close linkage of human chromosomal pepsinogen A genes.

PGA4 PGA5 PGA3

5.39e-0936233017318
Pubmed

Serum pepsinogen test for early detection of gastric cancer in a European country.

PGA4 PGA5 PGA3

5.39e-09362321989121
Pubmed

Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.

PGA4 PGA5 PGA3

5.39e-0936238053437
Pubmed

Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.

PGA4 PGA5 PGA3

5.39e-0936239855083
Pubmed

Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.

PGA4 PGA5 PGA3

5.39e-0936239797498
Pubmed

The glomerular sieving of pepsinogen A and C in man.

PGA4 PGA5 PGA3

5.39e-0936232478370
Pubmed

Analysis of the promoter of a human pepsinogen A gene.

PGA4 PGA5 PGA3

5.39e-0936231812762
Pubmed

O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.

PGA4 PGA5 PGA3

5.39e-0936237923573
Pubmed

Family and population studies on the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

5.39e-0936232566575
Pubmed

Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.

PGA4 PGA5 PGA3

5.39e-0936239061458
Pubmed

Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.

PGA4 PGA5 PGA3

5.39e-09362312588289
Pubmed

Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.

PGA4 PGA5 PGA3

5.39e-0936233815274
Pubmed

Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.

PGA4 PGA5 PGA3

5.39e-0936232229438
Pubmed

Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.

PGA4 PGA5 PGA3

5.39e-09362325314140
Pubmed

Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.

PGA4 PGA5 PGA3

5.39e-09362319890696
Pubmed

Pepsinogens: physiology, pharmacology pathophysiology and exercise.

PGA4 PGA5 PGA3

5.39e-09362310675278
Pubmed

Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.

PGA4 PGA5 PGA3

5.39e-09362323897256
Pubmed

An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.

PGA4 PGA5 PGA3

5.39e-09362311566730
Pubmed

The effect of acute and chronic protein loading on urinary pepsinogen A excretion.

PGA4 PGA5 PGA3

5.39e-0936231956484
Pubmed

The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.

PGA4 PGA5 PGA3

5.39e-0936237926498
Pubmed

Transcription regulation of human and porcine pepsinogen A.

PGA4 PGA5 PGA3

5.39e-0936238540382
Pubmed

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.

PGA4 PGA5 PGA3

5.39e-0936233780036
Pubmed

Crystal structure of human pepsinogen A.

PGA4 PGA5 PGA3

5.39e-0936239561228
Pubmed

Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

PGA4 PGA5 PGA3

5.39e-0936238244094
Pubmed

The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.

PGA4 PGA5 PGA3

5.39e-09362321455714
Pubmed

Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.

PGA4 PGA5 PGA3

5.39e-09362321407214
Pubmed

Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.

PGA4 PGA5 PGA3

5.39e-09362319800305
Pubmed

Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.

PGA4 PGA5 PGA3

5.39e-0936232901984
Pubmed

Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.

PGA4 PGA5 PGA3

5.39e-09362322992016
Pubmed

The role of serum pepsinogen in the detection of gastric cancer.

PGA4 PGA5 PGA3

5.39e-09362320981206
Pubmed

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

PGA4 PGA5 PGA3

5.39e-0936233839486
Pubmed

Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.

PGA4 PGA5 PGA3

5.39e-0936236774973
Pubmed

Gastric chief cell-specific transcription of the pepsinogen A gene.

PGA4 PGA5 PGA3

5.39e-0936238504820
Pubmed

Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.

PGA4 PGA5 PGA3

5.39e-09362321970995
Pubmed

Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.

PGA4 PGA5 PGA3

5.39e-09362324170207
Pubmed

Primary structure of human pepsinogen gene.

PGA4 PGA5 PGA3

5.39e-0936236300126
Pubmed

Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.

PGA4 PGA5 PGA3

5.39e-09362322304859
Pubmed

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.

PGA4 PGA5 PGA3

5.39e-09362324004680
Pubmed

Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.

PGA4 PGA5 PGA3

5.39e-0936238038355
Pubmed

Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.

PGA4 PGA5 PGA3

5.39e-0936233467902
Pubmed

The pepsinogens of human gastric mucosa.

PGA4 PGA5 PGA3

5.39e-0936234586732
Pubmed

Serum pepsinogens in gastric cancer screening.

PGA4 PGA5 PGA3

5.39e-09362320428942
Pubmed

Relationships between the human pepsinogen DNA and protein polymorphisms.

PGA4 PGA5 PGA3

5.39e-0936233014868
Pubmed

Human pepsinogen A isozymogen patterns in serum and gastric mucosa.

PGA4 PGA5 PGA3

5.39e-0936232227273
Pubmed

Genomic structure and evolution of the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

5.39e-0936232892778
Pubmed

The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.

PGA4 PGA5 PGA3

5.39e-09362324383519
Pubmed

The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.

PGA4 PGA5 PGA3

5.39e-0936239525001
Pubmed

Gene structures of pepsinogens A and C.

PGA4 PGA5 PGA3

5.39e-0936231455184
Pubmed

Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.

PGA4 PGA5 PGA3

5.39e-0936237886402
Pubmed

Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.

PGA4 PGA5 PGA3

5.39e-0936232831884
Pubmed

Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.

PGA4 PGA5 PGA3

5.39e-09362323034090
Pubmed

A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.

PGA4 PGA5 PGA3

5.39e-09362324125879
Pubmed

Serum pepsinogen and gastric cancer screening.

PGA4 PGA5 PGA3

5.39e-09362317379991
Pubmed

Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.

PGA4 PGA5 PGA3

5.39e-0936238751234
Pubmed

Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.

PGA4 PGA5 PGA3

5.39e-0936233554488
Pubmed

The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.

PGA4 PGA5 PGA3

5.39e-0936232799289
Pubmed

CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.

PGA4 PGA5 PGA3

5.39e-09362319872561
Pubmed

Human pepsinogen A (PGA): an informative gene complex located at 11q13.

PGA4 PGA5 PGA3

5.39e-0936231968039
Pubmed

Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.

PGA4 PGA5 PGA3

5.39e-09362321547904
Pubmed

Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.

PGA4 PGA5 PGA3

5.39e-09362323521833
Pubmed

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.

PGA4 PGA5 PGA3

2.16e-08462323047493
Pubmed

Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.

PGA4 PGA5 PGA3

2.16e-0846238322031
Pubmed

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.

PGA4 PGA5 PGA3

2.16e-08462317136346
Pubmed

Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

PGA4 PGA5 PGA3

2.16e-08462312698190
Pubmed

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.

PGA4 PGA5 PGA3

2.16e-08462311915945
Pubmed

Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.

PGA4 PGA5 PGA3

5.38e-08562322066020
Pubmed

Plexin signaling via off-track and rho family GTPases.

PLXNA3 PAK2 PLXNA1

1.52e-061362311604131
Pubmed

Crystal structure of human pepsin and its complex with pepstatin.

PGA4 PGA5

3.13e-0626227663352
Pubmed

Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.

PGA4 PGA5

3.13e-0626222415509
Pubmed

Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.

PGA4 PGA5

3.13e-0626222714789
Pubmed

Activation of human pepsinogens.

PGA4 PGA5

3.13e-0626223197840
Pubmed

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.

PGA4 PGA5 PGA3

4.32e-061862336057966
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PLXNA3 DNAJC10 MAP1B MRPL47 CTAGE8 FAM169A CTAGE15 MACF1 CCAR2 CTAGE6 CTAGE4 SLC4A3

7.79e-061442621235575683
Pubmed

Prognostic significance of PAK family kinases in acute myeloid leukemia.

PAK2 PAK3

9.37e-06362230890765
Pubmed

Identification of plexin family molecules in mice.

PLXNA3 PLXNA1

9.37e-0636228806646
Pubmed

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.

PAK2 PAK3

9.37e-06362210075701
Pubmed

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.

PAK2 PAK3

9.37e-06362215182717
Pubmed

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

PAK2 PAK3

9.37e-06362223335370
Pubmed

Group I Paks as therapeutic targets in NF2-deficient meningioma.

PAK2 PAK3

9.37e-06362225596744
Pubmed

Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.

PAK2 PAK3

9.37e-06362238785043
Pubmed

Differential expression of plexin-A subfamily members in the mouse nervous system.

PLXNA3 PLXNA1

9.37e-06362211241833
Pubmed

Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.

PLXNA3 PLXNA1

9.37e-06362220138877
Pubmed

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.

PAK2 PAK3

9.37e-06362211278486
Pubmed

The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.

PAK2 PAK3

9.37e-06362218507705
Pubmed

A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.

PGA4 PGA5

9.37e-0636222515193
Pubmed

Pak to the future.

PAK2 PAK3

1.87e-05462210461188
Pubmed

Determination of cell adhesion sites of neuropilin-1.

PLXNA3 PLXNA1

1.87e-05462210725340
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA3 PLXNA1

1.87e-05462211306810
Pubmed

CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.

PAK2 PAK3

1.87e-05462219819308
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA3 PLXNA1

1.87e-05462225518740
Pubmed

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PLXNA3 PLXNA1

1.87e-0546228570614
Pubmed

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.

PAK2 PAK3

3.12e-05562223509247
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

PLXNA3 PLXNA1

3.12e-05562225313870
Pubmed

Multiple roles of epithelial heparan sulfate in stomach morphogenesis.

PGA4 PGA5 PGA3

3.39e-053562329700203
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

PGA4 PGA5 PGA3

4.01e-053762321362171
Pubmed

Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.

PAK2 PAK3

4.67e-05662212237306
Pubmed

Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.

PAK2 PAK3

4.67e-05662233482876
Pubmed

Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.

PAK2 PAK3

4.67e-05662212213441
Pubmed

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

PLXNA3 PLXNA1

4.67e-05662219480842
InteractionCTAGE1 interactions

CTAGE8 CTAGE15 CTAGE6 CTAGE4

1.68e-0810624int:CTAGE1
InteractionMIA2 interactions

CTAGE8 CTAGE15 CTAGE6 CTAGE4 SERPINA12

2.54e-05113625int:MIA2
Cytoband7q35

CTAGE8 CTAGE15 CTAGE6 CTAGE4

9.76e-07556247q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

CTAGE8 CTAGE15 CTAGE6 CTAGE4

2.04e-0666624chr7q35
Cytoband1q32.2

PTPN14 UTP25

6.16e-04276221q32.2
Cytoband11q12.2

PGA4 PGA3

1.29e-033962211q12.2
CytobandEnsembl 112 genes in cytogenetic band chrXq22

TAF7L TBC1D8B SERPINA7

1.66e-03172623chrXq22
GeneFamilyCTAGE family

CTAGE8 CTAGE15 CTAGE6 CTAGE4

1.99e-0815374907
GeneFamilyPlexins

PLXNA3 PLXNA1

1.45e-049372683
GeneFamilySerpin peptidase inhibitors

SERPINA12 SERPINA7

2.59e-0337372739
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP

ANAPC1 SEL1L3 PAK3 UGT8 CTAGE15 CTAGE6 CTAGE4 TBC1D8B ADGRG4 EGFL6

1.11e-065876210M40869
Diseaseexploratory eye movement measurement

UGT8 CCAR2 NLRP8

4.23e-0481533EFO_0007700
DiseaseInborn Errors of Metabolism

ITPA SERPINA7

4.23e-0417532C0025521
Diseasealcoholic pancreatitis

TBC1D8B PLXNA1 SERPINA7

7.38e-0498533EFO_1002013
Diseaseepisodic memory

NBAS UGT8

3.96e-0352532EFO_0004333

Protein segments in the cluster

PeptideGeneStartEntry
HPLKQIKFLLGRKEE

CCAR2

341

Q8N163
DGHRGKSLKLLEKIP

SLC4A3

496

P48751
GHKKDIGRLKLLLPD

EGFL6

441

Q8IUX8
NLDDPLKGALKKLIH

CTAGE4

306

Q8IX94
NLDDPLKGALKKLIH

CTAGE6

306

Q86UF2
NLDDPLKGALKKLIH

CTAGE8

306

P0CG41
NLDDPLKGALKKLIH

CTAGE15

306

A4D2H0
EKQLKPFSKLLHEGR

BCAR3

681

O75815
QEGLKKIFEHKLLTP

ADGRG4

3026

Q8IZF6
KFQDTDGKHLLPKIR

PGD

241

P52209
ALPLKEEHKIFLLKV

PPP2R5C

236

Q13362
GPHKLVQKRFDKLLD

DNMBP

1116

Q6XZF7
PGRKKQFDLLLAEHK

ATXN7L1

326

Q9ULK2
LLHDLQIGEKKLLVK

RBM25

146

P49756
LKHLEPVDFLGKAKV

NOXA1

191

Q86UR1
PVLLPLLDDLFKVHK

INTS6L

391

Q5JSJ4
LLDDLFKVHKLKPNL

INTS6L

396

Q5JSJ4
GLLKDFLKKHNLNPA

PGA5

36

P0DJD9
LLPELHLLKQIKVKG

ANAPC1

1656

Q9H1A4
KELLQHPFLKLAKPL

PAK3

526

O75914
LPPALYKLHLKNNKL

PODN

236

Q7Z5L7
GLEKLKHLDFLKQPL

MAP1B

501

P46821
LVLRFLAKLHKKDPQ

MAGEL2

1196

Q9UJ55
KQQKHKPLELLLCFL

GPR162

41

Q16538
FGNKRKLLKVIPLLH

NLRP8

581

Q86W28
IEKNLESKNHPKLLL

PLXNA1

1416

Q9UIW2
IEKNLESKNHPKLLL

PLXNA3

1391

P51805
EEKLLPGLDLNHKQL

MME

671

P08473
NRPGKLKDLILLIKH

OAS2

191

P29728
LAKGDLKFPLKIFQH

NBAS

961

A2RRP1
HIDKLLKIGPQLKEL

MACF1

5836

Q9UPN3
GLLKDFLKKHNLNPA

PGA3

36

P0DJD8
KLIKKGFGLHELLNI

HMCN1

266

Q96RW7
AKELLQHPFLKLAKP

PAK2

491

Q13177
HALIQGLKKEKFDLL

UGT8

121

Q16880
LHKHLDGYKPLELLK

FASTKD1

366

Q53R41
EEKLSLLPRKKAHLG

FAM169A

511

Q9Y6X4
FLEKLKPEGLHQLLA

ITPA

91

Q9BY32
DPELKKLKTLLKNDH

DNAJC10

381

Q8IXB1
KKLIKALFDVLAHPQ

SCUBE2

951

Q9NQ36
LKNVPEHLAKLFKIE

DSEL

1051

Q8IZU8
RLKDFHQLLLNPPKK

PPP6R2

311

O75170
GLLKDFLKKHNLNPA

PGA4

36

P0DJD7
LKEHLRKGDNLVNKP

RFXANK

106

O14593
KDKLKIDLLPDGRHA

TAF7L

126

Q5H9L4
LSLKNKLKDLGHPVE

USO1

921

O60763
FKPPKDIDLKSLHLQ

UTP25

236

Q68CQ4
KELKDKHPSLFQALL

SEL1L3

501

Q68CR1
PKKIGILLDYEHSKL

FSD2

686

A1L4K1
PLKKHLDKFANEPLL

PTPN14

81

Q15678
LKLFLVKDPLLDFKG

SHOC1

111

Q5VXU9
LAKHQELPGKKLLSE

MTG2

51

Q9H4K7
GHLDQKDKFTKLRPL

PGBD1

511

Q96JS3
AKILLKKFPHLAEAQ

MRPL47

231

Q9HD33
LRDKLKPLLKHQAFE

SPTBN5

2181

Q9NRC6
IFILPDEGKLKHLEK

SERPINA12

271

Q8IW75
ENIYLIKLKKLIGPH

SLC7A14

526

Q8TBB6
TEKLKLLFKLHIPPA

TBC1D8B

896

Q0IIM8
KHGPKKIAELNLEAL

REXO5

381

Q96IC2
IGKHLKPLAKFLNDV

SERPINA7

136

P05543
LKPFEKFLLKLEGQL

WASHC4

241

Q2M389
HKLLGDKFKGQLELL

SMYD5

206

Q6GMV2
SKLLLLHFLKQDIPA

UNC79

1146

Q9P2D8