Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tRNA-4-demethylwyosine synthase activity	TYW1 TYW1B	3.72e-06	2	39	2	GO:0102521
GeneOntologyMolecularFunction	oxo-acid-lyase activity	TYW1 TYW1B	7.76e-05	7	39	2	GO:0016833
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO1 ABCA3 ATP8A2	1.34e-04	51	39	3	GO:0140303
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ABCA3 ATP8A2	3.33e-04	14	39	2	GO:0140333
GeneOntologyMolecularFunction	phospholipid transporter activity	ANO1 ABCA3 ATP8A2	4.06e-04	74	39	3	GO:0005548
GeneOntologyMolecularFunction	FMN binding	TYW1 TYW1B	4.38e-04	16	39	2	GO:0010181
GeneOntologyMolecularFunction	flippase activity	ABCA3 ATP8A2	4.96e-04	17	39	2	GO:0140327
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA3 ATP8A2	1.36e-03	28	39	2	GO:0140326
GeneOntologyBiologicalProcess	wybutosine metabolic process	TYW1 TYW1B	4.93e-05	6	38	2	GO:0031590
GeneOntologyBiologicalProcess	wybutosine biosynthetic process	TYW1 TYW1B	4.93e-05	6	38	2	GO:0031591
GeneOntologyCellularComponent	cell surface	KLRK1 TREM1 ANO1 PRND HHLA2 RORC NCR2 ADAM10 NTRK2	1.06e-04	1111	37	9	GO:0009986
HumanPheno	Howell-Jolly bodies	RPSA ABCB7	4.20e-05	4	14	2	HP:0032550
Domain	Wyosine_form	TYW1 TYW1B	4.03e-06	2	38	2	PF08608
Domain	tRNA_wybutosine-synth	TYW1 TYW1B	4.03e-06	2	38	2	IPR013917
Domain	Flavdoxin-like	TYW1 TYW1B	1.12e-04	8	38	2	IPR001094
Domain	FLAVODOXIN_LIKE	TYW1 TYW1B	1.12e-04	8	38	2	PS50902
Domain	Flavodoxin_1	TYW1 TYW1B	1.12e-04	8	38	2	PF00258
Domain	Flavodoxin/NO_synth	TYW1 TYW1B	1.12e-04	8	38	2	IPR008254
Domain	rSAM	TYW1 TYW1B	1.44e-04	9	38	2	IPR007197
Domain	Radical_SAM	TYW1 TYW1B	1.44e-04	9	38	2	PF04055
Domain	Flavoprotein-like_dom	TYW1 TYW1B	1.80e-04	10	38	2	IPR029039
Domain	-	TYW1 TYW1B	1.80e-04	10	38	2	3.40.50.360
Domain	IG	TREM1 HHLA2 NCR2 PXDNL NTRK2	1.55e-03	421	38	5	SM00409
Domain	Ig_sub	TREM1 HHLA2 NCR2 PXDNL NTRK2	1.55e-03	421	38	5	IPR003599
Domain	IG_LIKE	TREM1 HHLA2 NCR2 PXDNL NTRK2	3.02e-03	491	38	5	PS50835
Domain	ABC_transporter_CS	ABCA3 ABCB7	3.30e-03	42	38	2	IPR017871
Domain	-	TYW1 TYW1B	3.30e-03	42	38	2	3.20.20.70
Domain	Ig-like_dom	TREM1 HHLA2 NCR2 PXDNL NTRK2	3.35e-03	503	38	5	IPR007110
Domain	Aldolase_TIM	TYW1 TYW1B	3.61e-03	44	38	2	IPR013785
Domain	ABC_TRANSPORTER_2	ABCA3 ABCB7	4.29e-03	48	38	2	PS50893
Domain	ABC_tran	ABCA3 ABCB7	4.29e-03	48	38	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCA3 ABCB7	4.46e-03	49	38	2	PS00211
Domain	ABC_transporter-like	ABCA3 ABCB7	4.64e-03	50	38	2	IPR003439
Domain	V-set	TREM1 HHLA2 NCR2	6.16e-03	184	38	3	PF07686
Domain	Ig_V-set	TREM1 HHLA2 NCR2	7.64e-03	199	38	3	IPR013106
Pathway	REACTOME_DAP12_INTERACTIONS	KLRK1 TREM1 NCR2	1.24e-04	46	30	3	M27151
Pubmed	The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two-hybrid system.	PRND RPSA	1.29e-06	2	40	2	15158907
Pubmed	Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D.	KLRK1 NCR2	1.29e-06	2	40	2	16210654
Pubmed	Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.	TYW1 TYW1B	1.29e-06	2	40	2	16162496
Pubmed	Interaction of Doppel with the full-length laminin receptor precursor protein.	PRND RPSA	1.29e-06	2	40	2	15246873
Pubmed	High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.	KLRK1 ADAM10	3.87e-06	3	40	2	22167753
Pubmed	Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.	KLRK1 NCR2	7.73e-06	4	40	2	15657183
Pubmed	Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.	TYW1 TYW1B	7.73e-06	4	40	2	17150819
Pubmed	Tumor-associated MICA is shed by ADAM proteases.	KLRK1 ADAM10	1.93e-05	6	40	2	18676862
Pubmed	Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.	KLRK1 NCR2	1.93e-05	6	40	2	24673109
Pubmed	Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading.	MIS18A DNMT3B	3.60e-05	8	40	2	22516971
Pubmed	The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.	TREM1 NCR2	3.60e-05	8	40	2	12645956
Pubmed	Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).	ADAM10 SNX18	1.34e-04	15	40	2	25036101
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCA3 ABCB7	3.21e-04	23	40	2	10708515
Pubmed	Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.	ABCA3 ADAM10	4.12e-04	26	40	2	31562139
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	PTPRE DNMT3B	4.78e-04	28	40	2	26812015
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ANO1 ZNFX1 DENND3	7.18e-04	152	40	3	34299191
Cytoband	7p22.1	RSPH10B2 RSPH10B	7.81e-04	47	40	2	7p22.1
GeneFamily	Adenosine receptors\|V-set domain containing	TREM1 HHLA2 NCR2	1.79e-03	163	27	3	590
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	KLRK1 TREM1 NCR2 ADAM10	2.62e-03	394	27	4	471
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PXDNL NTRK2	2.39e-02	161	27	2	593
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 BRINP2 PRND TMEM54 NTRK2	6.18e-07	183	40	5	f55081068213cc1cdb2acad58ff10f6b48b44c72
Disease	response to methotrexate, drug-induced liver injury	ATP8A2 SNX18	5.15e-04	26	38	2	EFO_0004228, GO_0031427
Disease	oral squamous cell carcinoma (is_implicated_in)	BRINP2 DNMT3B	5.98e-04	28	38	2	DOID:0050866 (is_implicated_in)
Disease	hepatitis C (is_marker_for)	KLRK1 TREM1	9.35e-04	35	38	2	DOID:1883 (is_marker_for)
Disease	depressive disorder (biomarker_via_orthology)	TREM1 NTRK2	2.06e-03	52	38	2	DOID:1596 (biomarker_via_orthology)
Disease	Alzheimer's disease (biomarker_via_orthology)	ADAM10 NTRK2	2.55e-03	58	38	2	DOID:10652 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRKTRLWGLLWMLFV	TREM1	1	Q9NP99
WKATSKRQAMSGMRW	DNMT3B	246	Q9UBC3
AHWWAVLLMGIALIM	ADAM10	676	O14672
KEYMRMMGLSSWLHW	ABCA3	291	Q99758
CDLWHLMVKEMWAGK	DENND3	801	A2RUS2
VLRNGMWHTIMWKEV	ATP8A2	156	Q9NTI2
GWMDMTIHEGKRWSA	CHDH	226	Q8NE62
RRSWIMQALGSWKMS	MROH7	1306	Q68CQ1
HNRMLLWHGSRMSNW	PARP2	421	Q9UGN5
WEDNMRHGEGRMRWL	RSPH10B	231	P0C881
WEDNMRHGEGRMRWL	RSPH10B2	231	B2RC85
WRMIWEWKSHTIVML	PTPRE	511	P23469
GDIWWKTMMELRSLD	NCR2	216	O95944
AKSWKLHYRWTMALM	PDE1A	371	P54750
MGWIRGRRSRHSWEM	KLRK1	1	P26718
WTGRWTMKDGLHKMQ	HHLA2	221	Q9UM44
LRDAWGILMDMRWRW	KCNJ13	41	O60928
MALWAATFMEHWKRK	ANO1	416	Q5XXA6
RMLMHWGWFLEHDLD	PXDNL	801	A1KZ92
HVLWMLLTGKLWEML	GPR157	166	Q5UAW9
KGAHSVGLMWWMLAR	RPSA	166	P08865
WDRASHRGLVKMRIW	RTP5	76	Q14D33
HSLFLWLRWRMNGMI	TAS2R42	116	Q7RTR8
DMSGIMKWSEIWRLK	TRIM34	251	Q9BYJ4
LTLTWKRMSARRMQW	FAM120AOS	106	Q5T036
MALLAMHSWRWAAAA	ABCB7	1	O75027
MRLGSWFDPSWRKRM	BRINP2	536	Q9C0B6
MQWLMRFRTLWGIHK	ACSM1	1	Q08AH1
MSSWIRWHGPAMARL	NTRK2	1	Q16620
ELRPWWGKSSHHMMR	TMEM54	186	Q969K7
WHADVATVMWRRMLG	RALGAPA1	1056	Q6GYQ0
KSMWEMWERCAHHLT	RORC	311	P51449
RHQLLQKWASMWSSM	MIS18A	41	Q9NYP9
KRRKGLIWWMNHMAS	SNX18	351	Q96RF0
MRKHLSWWWLATVCM	PRND	1	Q9UKY0
RSWMNRWKSAVLHEG	VPS41	156	P49754
HWKHSMMLEWLGLGV	ZNFX1	776	Q9P2E3
DKWLWMLGAHRVMSR	TYW1	196	Q9NV66
RLWDRNMDIAMGWKG	TRMT10C	181	Q7L0Y3
KWLWMLGVHRVMSRG	TYW1B	151	Q6NUM6