Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3T6 kinase activity	PRKCA PRKCB	1.90e-06	2	28	2	GO:0035403
GeneOntologyMolecularFunction	histone H3 kinase activity	PRKCA PRKCB	1.24e-04	12	28	2	GO:0140996
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCA PRKCB	2.25e-04	16	28	2	GO:0004697
GeneOntologyMolecularFunction	histone kinase activity	PRKCA PRKCB	7.01e-04	28	28	2	GO:0035173
GeneOntologyMolecularFunction	protein serine kinase activity	DCLK3 ROCK2 PRKCA PRKCB	1.56e-03	363	28	4	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	DCLK3 ROCK2 PRKCA PRKCB	3.29e-03	446	28	4	GO:0004674
GeneOntologyMolecularFunction	chromatin binding	TRIM66 PRKCB FANCM ADNP PHF10	3.32e-03	739	28	5	GO:0003682
GeneOntologyBiologicalProcess	regulation of angiotensin-activated signaling pathway	ROCK2 PRKCA	1.06e-05	4	28	2	GO:0110061
GeneOntologyBiologicalProcess	response to carbohydrate	PRKCA PRKCB ADNP ABCA12 ADCY5	4.78e-05	301	28	5	GO:0009743
GeneOntologyBiologicalProcess	mitotic nuclear membrane disassembly	PRKCA PRKCB	4.95e-05	8	28	2	GO:0007077
GeneOntologyBiologicalProcess	mitotic cell cycle process	CKAP5 ROCK2 PRKCA PRKCB INTS3 PHF10 ANAPC2	1.12e-04	854	28	7	GO:1903047
GeneOntologyBiologicalProcess	cell morphogenesis	MKLN1 ROCK2 PRKCA SCN11A KLHL10 ADNP ANAPC2 SOS1	1.35e-04	1194	28	8	GO:0000902
GeneOntologyBiologicalProcess	nuclear membrane disassembly	PRKCA PRKCB	1.37e-04	13	28	2	GO:0051081
GeneOntologyBiologicalProcess	membrane disassembly	PRKCA PRKCB	1.60e-04	14	28	2	GO:0030397
GeneOntologyBiologicalProcess	membrane organization	UBAP1 ZNRF1 S100A10 PRKCA PRKCB PPM1K ABCA12	1.71e-04	914	28	7	GO:0061024
GeneOntologyBiologicalProcess	cellular response to carbohydrate stimulus	PRKCA PRKCB ABCA12 ADCY5	1.93e-04	215	28	4	GO:0071322
GeneOntologyBiologicalProcess	protein localization to early endosome	MKLN1 ROCK2	2.11e-04	16	28	2	GO:1902946
GeneOntologyBiologicalProcess	exocytosis	S100A10 PRKCA PRKCB SCN11A ABCA12	2.66e-04	434	28	5	GO:0006887
GeneOntologyBiologicalProcess	mitotic cell cycle	CKAP5 ROCK2 PRKCA PRKCB INTS3 PHF10 ANAPC2	3.24e-04	1014	28	7	GO:0000278
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	ROCK2 PRKCA SCN11A ADNP ANAPC2 SOS1	4.24e-04	748	28	6	GO:0048667
GeneOntologyBiologicalProcess	post-translational protein modification	ZNRF1 PRKCA PRKCB KLHL10 FANCM MKRN2 ANAPC2	4.59e-04	1074	28	7	GO:0043687
GeneOntologyBiologicalProcess	angiotensin-activated signaling pathway	ROCK2 PRKCA	4.81e-04	24	28	2	GO:0038166
GeneOntologyBiologicalProcess	cell cycle process	CKAP5 ROCK2 PRKCA PRKCB FANCM INTS3 PHF10 ANAPC2	4.89e-04	1441	28	8	GO:0022402
GeneOntologyBiologicalProcess	regulation of cell development	ROCK2 S100A10 PRKCA ADNP PHF10 ANAPC2 SOS1	5.16e-04	1095	28	7	GO:0060284
GeneOntologyBiologicalProcess	regulated exocytosis	PRKCA PRKCB SCN11A ABCA12	6.08e-04	291	28	4	GO:0045055
GeneOntologyBiologicalProcess	neuron projection morphogenesis	ROCK2 PRKCA SCN11A ADNP ANAPC2 SOS1	6.13e-04	802	28	6	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	ROCK2 PRKCA SCN11A ADNP ANAPC2 SOS1	6.85e-04	819	28	6	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	ROCK2 PRKCA SCN11A ADNP ANAPC2 SOS1	7.16e-04	826	28	6	GO:0048858
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	DCLK3 ROCK2 PRKCA PRKCB	7.43e-04	307	28	4	GO:0018105
GeneOntologyBiologicalProcess	negative regulation of D-glucose transmembrane transport	PRKCA PRKCB	7.55e-04	30	28	2	GO:0010829
GeneOntologyBiologicalProcess	regulation of cell junction assembly	ROCK2 S100A10 PRKCA ADNP	7.62e-04	309	28	4	GO:1901888
GeneOntologyBiologicalProcess	response to alcohol	PRKCA PRKCB SCN11A ADCY5	7.89e-04	312	28	4	GO:0097305
GeneOntologyBiologicalProcess	regulation of synapse maturation	ROCK2 ANAPC2	8.06e-04	31	28	2	GO:0090128
GeneOntologyBiologicalProcess	positive regulation of cell junction assembly	S100A10 PRKCA ADNP	8.14e-04	136	28	3	GO:1901890
GeneOntologyBiologicalProcess	peptidyl-serine modification	DCLK3 ROCK2 PRKCA PRKCB	8.57e-04	319	28	4	GO:0018209
GeneOntologyBiologicalProcess	axonogenesis	PRKCA SCN11A ADNP ANAPC2 SOS1	8.90e-04	566	28	5	GO:0007409
GeneOntologyBiologicalProcess	protein localization to endosome	MKLN1 ROCK2	9.14e-04	33	28	2	GO:0036010
GeneOntologyBiologicalProcess	positive regulation of cellular component biogenesis	CKAP5 ROCK2 S100A10 PRKCA ADNP	1.01e-03	582	28	5	GO:0044089
Domain	Protein_kinase_C_a/b/g	PRKCA PRKCB	6.50e-06	3	28	2	IPR014375
Domain	Pkinase_C	ROCK2 PRKCA PRKCB	2.27e-05	37	28	3	IPR017892
Domain	Pkinase_C	ROCK2 PRKCA PRKCB	3.33e-05	42	28	3	PF00433
Domain	AGC-kinase_C	ROCK2 PRKCA PRKCB	7.93e-05	56	28	3	IPR000961
Domain	AGC_KINASE_CTER	ROCK2 PRKCA PRKCB	7.93e-05	56	28	3	PS51285
Domain	S_TK_X	ROCK2 PRKCA PRKCB	7.93e-05	56	28	3	SM00133
Domain	C1_1	ROCK2 PRKCA PRKCB	8.36e-05	57	28	3	PF00130
Domain	ZF_DAG_PE_1	ROCK2 PRKCA PRKCB	1.18e-04	64	28	3	PS00479
Domain	ZF_DAG_PE_2	ROCK2 PRKCA PRKCB	1.18e-04	64	28	3	PS50081
Domain	C1	ROCK2 PRKCA PRKCB	1.24e-04	65	28	3	SM00109
Domain	PE/DAG-bd	ROCK2 PRKCA PRKCB	1.30e-04	66	28	3	IPR002219
Domain	DAG/PE-bd	PRKCA PRKCB	4.47e-04	21	28	2	IPR020454
Domain	Kinase-like_dom	DCLK3 ROCK2 PRKCA PRKCB SOS1	1.14e-03	542	28	5	IPR011009
Domain	Ser/Thr_kinase_AS	DCLK3 ROCK2 PRKCA PRKCB	1.87e-03	357	28	4	IPR008271
Domain	S_TKc	DCLK3 ROCK2 PRKCA PRKCB	1.91e-03	359	28	4	SM00220
Domain	PROTEIN_KINASE_ST	DCLK3 ROCK2 PRKCA PRKCB	1.97e-03	362	28	4	PS00108
Domain	Protein_kinase_ATP_BS	DCLK3 ROCK2 PRKCA PRKCB	2.32e-03	379	28	4	IPR017441
Domain	Pkinase	DCLK3 ROCK2 PRKCA PRKCB	2.37e-03	381	28	4	PF00069
Domain	Gal_Oxase/kelch_b-propeller	MKLN1 KLHL10	3.52e-03	59	28	2	IPR011043
Domain	-	ZNRF1 TRIM66 PHF10 MKRN2	4.27e-03	449	28	4	3.30.40.10
Domain	PROTEIN_KINASE_ATP	DCLK3 ROCK2 PRKCA PRKCB	4.62e-03	459	28	4	PS00107
Domain	Znf_RING/FYVE/PHD	ZNRF1 TRIM66 PHF10 MKRN2	4.62e-03	459	28	4	IPR013083
Domain	Kelch_1	MKLN1 KLHL10	4.91e-03	70	28	2	PF01344
Domain	Kelch_1	MKLN1 KLHL10	4.91e-03	70	28	2	IPR006652
Domain	PHD	TRIM66 PHF10	5.62e-03	75	28	2	PF00628
Domain	Prot_kinase_dom	DCLK3 ROCK2 PRKCA PRKCB	5.77e-03	489	28	4	IPR000719
Domain	PROTEIN_KINASE_DOM	DCLK3 ROCK2 PRKCA PRKCB	5.94e-03	493	28	4	PS50011
Domain	Znf_PHD-finger	TRIM66 PHF10	6.22e-03	79	28	2	IPR019787
Domain	PHD	TRIM66 PHF10	7.83e-03	89	28	2	SM00249
Domain	Znf_PHD	TRIM66 PHF10	8.17e-03	91	28	2	IPR001965
Domain	ZF_PHD_2	TRIM66 PHF10	8.88e-03	95	28	2	PS50016
Domain	ZF_PHD_1	TRIM66 PHF10	9.06e-03	96	28	2	PS01359
Pathway	BIOCARTA_TRKA_PATHWAY	PRKCA PRKCB SOS1	7.49e-07	14	19	3	M9134
Pathway	BIOCARTA_TRKA_PATHWAY	PRKCA PRKCB SOS1	9.35e-07	15	19	3	MM1523
Pathway	BIOCARTA_CCR3_PATHWAY	ROCK2 PRKCA PRKCB	1.98e-06	19	19	3	MM1361
Pathway	BIOCARTA_CCR3_PATHWAY	ROCK2 PRKCA PRKCB	1.98e-06	19	19	3	M9152
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB SOS1	2.33e-06	20	19	3	MM1520
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB SOS1	3.15e-06	22	19	3	M9070
Pathway	BIOCARTA_TPO_PATHWAY	PRKCA PRKCB SOS1	4.13e-06	24	19	3	M11520
Pathway	BIOCARTA_TPO_PATHWAY	PRKCA PRKCB SOS1	4.69e-06	25	19	3	MM1519
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB SOS1	5.29e-06	26	19	3	MM1346
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB SOS1	5.29e-06	26	19	3	MM1431
Pathway	KEGG_GAP_JUNCTION	PRKCA PRKCB ADCY5 SOS1	5.60e-06	90	19	4	M4013
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB SOS1	5.95e-06	27	19	3	M14899
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB SOS1	5.95e-06	27	19	3	M7739
Pathway	BIOCARTA_GH_PATHWAY	PRKCA PRKCB SOS1	5.95e-06	27	19	3	M9043
Pathway	BIOCARTA_EGF_PATHWAY	PRKCA PRKCB SOS1	5.95e-06	27	19	3	M1909
Pathway	BIOCARTA_EGF_PATHWAY	PRKCA PRKCB SOS1	6.66e-06	28	19	3	MM1386
Pathway	BIOCARTA_PDGF_PATHWAY	PRKCA PRKCB SOS1	6.66e-06	28	19	3	M2529
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	PRKCA PRKCB SOS1	7.42e-06	29	19	3	MM1356
Pathway	BIOCARTA_PDGF_PATHWAY	PRKCA PRKCB SOS1	7.42e-06	29	19	3	MM1452
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	PRKCA PRKCB SOS1	7.42e-06	29	19	3	M13494
Pathway	WP_PDGFRBETA_PATHWAY	PRKCA PRKCB SOS1	7.42e-06	29	19	3	M39616
Pathway	PID_RAS_PATHWAY	PRKCA PRKCB SOS1	8.24e-06	30	19	3	M269
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	PRKCA PRKCB ADCY5 SOS1	8.86e-06	101	19	4	M1979
Pathway	BIOCARTA_BCR_PATHWAY	PRKCA PRKCB SOS1	1.00e-05	32	19	3	MM1355
Pathway	BIOCARTA_BCR_PATHWAY	PRKCA PRKCB SOS1	1.10e-05	33	19	3	M9494
Pathway	BIOCARTA_GH_PATHWAY	PRKCA PRKCB SOS1	1.10e-05	33	19	3	MM1404
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	ROCK2 PRKCA PRKCB ADCY5	1.48e-05	115	19	4	M9387
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	1.72e-05	5	19	2	MM1574
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	1.72e-05	5	19	2	MM1587
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	1.72e-05	5	19	2	M22059
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	1.72e-05	5	19	2	M22080
Pathway	REACTOME_DISINHIBITION_OF_SNARE_FORMATION	PRKCA PRKCB	1.72e-05	5	19	2	M26920
Pathway	BIOCARTA_TCR_PATHWAY	PRKCA PRKCB SOS1	2.31e-05	42	19	3	MM1504
Pathway	PID_THROMBIN_PAR1_PATHWAY	ROCK2 PRKCA PRKCB	2.48e-05	43	19	3	M238
Pathway	BIOCARTA_TCR_PATHWAY	PRKCA PRKCB SOS1	2.65e-05	44	19	3	M19784
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	PRKCA PRKCB ADCY5	3.46e-05	48	19	3	M10775
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	3.60e-05	7	19	2	MM1563
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	3.60e-05	7	19	2	MM1572
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	3.60e-05	7	19	2	M22043
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	3.60e-05	7	19	2	M22057
Pathway	PID_CD8_TCR_PATHWAY	PRKCA PRKCB SOS1	4.66e-05	53	19	3	M88
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US27_TO_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	4.80e-05	8	19	2	M47555
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	4.80e-05	8	19	2	M47479
Pathway	KEGG_NON_SMALL_CELL_LUNG_CANCER	PRKCA PRKCB SOS1	4.93e-05	54	19	3	M19818
Pathway	WP_CHEMOKINE_SIGNALING	ROCK2 PRKCB ADCY5 SOS1	6.12e-05	165	19	4	M39400
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	6.16e-05	9	19	2	M22029
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	6.16e-05	9	19	2	MM1551
Pathway	REACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN	PRKCA SOS1	6.16e-05	9	19	2	M27156
Pathway	WP_KIT_RECEPTOR_SIGNALING	PRKCA PRKCB SOS1	6.43e-05	59	19	3	M39350
Pathway	BIOCARTA_SRCRPTP_PATHWAY	PRKCA PRKCB	7.70e-05	10	19	2	MM1341
Pathway	BIOCARTA_AGPCR_PATHWAY	PRKCA PRKCB	7.70e-05	10	19	2	MM1352
Pathway	KEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	7.70e-05	10	19	2	M47644
Pathway	PID_ENDOTHELIN_PATHWAY	PRKCA PRKCB ADCY5	7.83e-05	63	19	3	M8
Pathway	PID_TCR_PATHWAY	PRKCA PRKCB SOS1	8.21e-05	64	19	3	M34
Pathway	WP_ONCOSTATIN_M_SIGNALING	PRKCA PRKCB SOS1	8.60e-05	65	19	3	M39562
Pathway	KEGG_GLIOMA	PRKCA PRKCB SOS1	8.60e-05	65	19	3	M1835
Pathway	WP_CHEMOKINE_SIGNALING_PATHWAY	ROCK2 PRKCB ADCY5 SOS1	9.34e-05	184	19	4	MM15943
Pathway	BIOCARTA_CBL_PATHWAY	PRKCA PRKCB	9.40e-05	11	19	2	MM1360
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	9.40e-05	11	19	2	M47637
Pathway	BIOCARTA_SRCRPTP_PATHWAY	PRKCA PRKCB	9.40e-05	11	19	2	M10994
Pathway	BIOCARTA_MYOSIN_PATHWAY	PRKCA PRKCB	9.40e-05	11	19	2	M7014
Pathway	BIOCARTA_AGPCR_PATHWAY	PRKCA PRKCB	9.40e-05	11	19	2	M19829
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	ROCK2 PRKCB ADCY5 SOS1	1.02e-04	188	19	4	M4844
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	PRKCA PRKCB SOS1	1.12e-04	71	19	3	MM15947
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.13e-04	12	19	2	M47597
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.13e-04	12	19	2	M47649
Pathway	KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY	PRKCA PRKCB	1.13e-04	12	19	2	M47628
Pathway	BIOCARTA_CBL_PATHWAY	PRKCA PRKCB	1.13e-04	12	19	2	M16973
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	PRKCA PRKCB SOS1	1.17e-04	72	19	3	M39738
Pathway	WP_FOCAL_ADHESION	ROCK2 PRKCA PRKCB SOS1	1.26e-04	199	19	4	M39402
Pathway	KEGG_FOCAL_ADHESION	ROCK2 PRKCA PRKCB SOS1	1.26e-04	199	19	4	M7253
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	PRKCA PRKCB	1.33e-04	13	19	2	M47656
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	PRKCA PRKCB SOS1	1.54e-04	79	19	3	M11816
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.55e-04	14	19	2	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.55e-04	14	19	2	M47384
Pathway	PID_TCR_RAS_PATHWAY	PRKCA PRKCB	1.55e-04	14	19	2	M134
Pathway	BIOCARTA_CDMAC_PATHWAY	PRKCA PRKCB	1.79e-04	15	19	2	MM1358
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.79e-04	15	19	2	M47382
Pathway	REACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA	PRKCA PRKCB	1.79e-04	15	19	2	M27360
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	PRKCA PRKCB	1.79e-04	15	19	2	M27413
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	PRKCA PRKCB SOS1	1.85e-04	84	19	3	M39839
Pathway	BIOCARTA_MEF2D_PATHWAY	PRKCA PRKCB	2.04e-04	16	19	2	MM1483
Pathway	BIOCARTA_SPPA_PATHWAY	PRKCA PRKCB	2.04e-04	16	19	2	M8731
Pathway	BIOCARTA_CDMAC_PATHWAY	PRKCA PRKCB	2.04e-04	16	19	2	M4388
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	PRKCA SOS1	2.04e-04	16	19	2	M537
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	PRKCA PRKCB SOS1	2.05e-04	87	19	3	M12467
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	PRKCA PRKCB ADCY5	2.26e-04	90	19	3	MM15882
Pathway	BIOCARTA_CCR5_PATHWAY	PRKCA PRKCB	2.31e-04	17	19	2	M2349
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	PRKCA PRKCB	2.31e-04	17	19	2	M5488
Pathway	WP_G_PROTEIN_SIGNALING	PRKCA PRKCB ADCY5	2.34e-04	91	19	3	M39426
Pathway	WP_ERBB_SIGNALING	PRKCA PRKCB SOS1	2.42e-04	92	19	3	M39715
Pathway	BIOCARTA_CHEMICAL_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	MM1350
Pathway	BIOCARTA_CARDIACEGF_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	M7552
Pathway	BIOCARTA_MEF2D_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	M5290
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	PRKCA SOS1	2.60e-04	18	19	2	M657
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	MM1385
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	M3430
Pathway	BIOCARTA_CARDIACEGF_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	MM1479
Pathway	BIOCARTA_CHEMICAL_PATHWAY	PRKCA PRKCB	2.60e-04	18	19	2	M3873
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	PRKCA PRKCB	2.90e-04	19	19	2	M47596
Pubmed	Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.	PRKCA PRKCB	6.71e-07	2	29	2	26660275
Pubmed	Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.	PRKCA PRKCB	6.71e-07	2	29	2	25616575
Pubmed	PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.	PRKCA PRKCB	6.71e-07	2	29	2	23439007
Pubmed	Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.	PRKCA PRKCB	6.71e-07	2	29	2	16673150
Pubmed	Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.	PRKCA PRKCB	6.71e-07	2	29	2	16517978
Pubmed	Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2.	PRKCA PRKCB	6.71e-07	2	29	2	25693686
Pubmed	All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression.	PRKCA PRKCB	6.71e-07	2	29	2	33723318
Pubmed	Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC.	PRKCA PRKCB	6.71e-07	2	29	2	22993418
Pubmed	Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.	PRKCA PRKCB	6.71e-07	2	29	2	21658591
Pubmed	Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.	PRKCA PRKCB	6.71e-07	2	29	2	24151077
Pubmed	The essentiality of PKCalpha and PKCbetaI translocation for CD14+monocyte differentiation towards macrophages and dendritic cells, respectively.	PRKCA PRKCB	6.71e-07	2	29	2	17455194
Pubmed	Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.	PRKCA PRKCB	6.71e-07	2	29	2	27657532
Pubmed	Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-α and βI isozymes.	PRKCA PRKCB	6.71e-07	2	29	2	21323641
Pubmed	Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held.	PRKCA PRKCB	6.71e-07	2	29	2	23035091
Pubmed	Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells.	PRKCA PRKCB	6.71e-07	2	29	2	9486851
Pubmed	Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.	PRKCA PRKCB	6.71e-07	2	29	2	29307535
Pubmed	Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.	PRKCA PRKCB	6.71e-07	2	29	2	16080189
Pubmed	Receptor-specific regulation of atrial GIRK channel activity by different Ca2+-dependent PKC isoforms.	PRKCA PRKCB	6.71e-07	2	29	2	31525436
Pubmed	Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.	PRKCA PRKCB	6.71e-07	2	29	2	16430878
Pubmed	Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.	PRKCA PRKCB	6.71e-07	2	29	2	28415683
Pubmed	Inhibition of the calcium release-activated calcium (CRAC) current in Jurkat T cells by the HIV-1 envelope protein gp160.	PRKCA PRKCB	6.71e-07	2	29	2	11744714
Pubmed	cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.	PRKCA PRKCB	6.71e-07	2	29	2	14527960
Pubmed	Unravelling the different functions of protein kinase C isoforms in platelets.	PRKCA PRKCB	6.71e-07	2	29	2	21596041
Pubmed	Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.	PRKCA PRKCB	2.01e-06	3	29	2	1714454
Pubmed	Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.	PRKCA PRKCB	2.01e-06	3	29	2	32367578
Pubmed	Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.	PRKCA PRKCB	2.01e-06	3	29	2	23434935
Pubmed	Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.	PRKCA PRKCB	2.01e-06	3	29	2	1324914
Pubmed	A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells.	PRKCA PRKCB	2.01e-06	3	29	2	24316392
Pubmed	Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.	PRKCA PRKCB	2.01e-06	3	29	2	9814702
Pubmed	Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.	PRKCA PRKCB	2.01e-06	3	29	2	19895572
Pubmed	Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms.	PRKCA PRKCB	2.01e-06	3	29	2	22670899
Pubmed	Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.	PRKCA PRKCB	2.01e-06	3	29	2	19556521
Pubmed	Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans.	PRKCA PRKCB	2.01e-06	3	29	2	16775601
Pubmed	Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.	PRKCA PRKCB	2.01e-06	3	29	2	17936705
Pubmed	Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney.	PRKCA PRKCB	2.01e-06	3	29	2	16735462
Pubmed	Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.	PRKCA PRKCB	2.01e-06	3	29	2	30904392
Pubmed	Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.	PRKCA PRKCB	2.01e-06	3	29	2	23028752
Pubmed	PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport.	PRKCA PRKCB	2.01e-06	3	29	2	23977398
Pubmed	Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice.	PRKCA PRKCB	2.01e-06	3	29	2	7760054
Pubmed	Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling.	PRKCA PRKCB	2.01e-06	3	29	2	20237998
Pubmed	S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.	PRKCA PRKCB	2.01e-06	3	29	2	18162471
Pubmed	Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.	PRKCA PRKCB	2.01e-06	3	29	2	19066285
Pubmed	Mapping of a regulatory important site for protein kinase C phosphorylation in the N-terminal domain of annexin II.	S100A10 PRKCB	2.01e-06	3	29	2	8898866
Pubmed	The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.	PRKCA PRKCB	2.01e-06	3	29	2	12080070
Pubmed	Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates.	PRKCA PRKCB	2.01e-06	3	29	2	18313852
Pubmed	Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.	PRKCA PRKCB	2.01e-06	3	29	2	22819675
Pubmed	Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.	PRKCA PRKCB	2.01e-06	3	29	2	3755548
Pubmed	Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse.	PRKCA PRKCB	2.01e-06	3	29	2	27307229
Pubmed	Nanomolar amyloid beta protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells.	PRKCA PRKCB	4.02e-06	4	29	2	11930178
Pubmed	Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.	PRKCA PRKCB	4.02e-06	4	29	2	9244383
Pubmed	Phosphorylation of p300 at serine 89 by protein kinase C.	PRKCA PRKCB	4.02e-06	4	29	2	11020388
Pubmed	STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.	PRKCA PRKCB	4.02e-06	4	29	2	24493668
Pubmed	Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.	PRKCA PRKCB	4.02e-06	4	29	2	26404773
Pubmed	Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.	PRKCA PRKCB	4.02e-06	4	29	2	10856305
Pubmed	Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase.	PRKCA PRKCB	4.02e-06	4	29	2	19681907
Pubmed	Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.	PRKCA PRKCB	4.02e-06	4	29	2	15367584
Pubmed	Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.	PRKCA PRKCB	4.02e-06	4	29	2	15499829
Pubmed	Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.	PRKCA PRKCB	4.02e-06	4	29	2	10871288
Pubmed	PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.	PRKCA PRKCB	4.02e-06	4	29	2	8557118
Pubmed	Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.	PRKCA PRKCB	4.02e-06	4	29	2	12950453
Pubmed	Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.	PRKCA PRKCB	4.02e-06	4	29	2	8631738
Pubmed	Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.	PRKCA PRKCB	4.02e-06	4	29	2	22318721
Pubmed	Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKCα and βI to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol.	PRKCA PRKCB	4.02e-06	4	29	2	20618341
Pubmed	Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.	PRKCA PRKCB	4.02e-06	4	29	2	7499337
Pubmed	Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.	PRKCA PRKCB	4.02e-06	4	29	2	9694886
Pubmed	Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1.	PRKCA PRKCB	4.02e-06	4	29	2	34290081
Pubmed	Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.	PRKCA PRKCB	4.02e-06	4	29	2	8662663
Pubmed	Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition.	PRKCA PRKCB	4.02e-06	4	29	2	24401212
Pubmed	Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.	PRKCA PRKCB	4.02e-06	4	29	2	7873880
Pubmed	Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.	PRKCA PRKCB	4.02e-06	4	29	2	11063746
Pubmed	Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.	PRKCA PRKCB	4.02e-06	4	29	2	8080473
Pubmed	Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.	PRKCA PRKCB	4.02e-06	4	29	2	10531036
Pubmed	A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.	PRKCA PRKCB	6.70e-06	5	29	2	7513693
Pubmed	Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst.	PRKCA PRKCB	6.70e-06	5	29	2	11145703
Pubmed	Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.	PRKCA PRKCB	6.70e-06	5	29	2	12569090
Pubmed	Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.	PRKCA PRKCB	6.70e-06	5	29	2	11325528
Pubmed	Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth.	PRKCA PRKCB	6.70e-06	5	29	2	33917019
Pubmed	Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling.	PRKCA PRKCB	6.70e-06	5	29	2	11123317
Pubmed	Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.	PRKCA PRKCB	6.70e-06	5	29	2	2590242
Pubmed	PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity.	PRKCA PRKCB	6.70e-06	5	29	2	30013171
Pubmed	Protein kinase C activity regulates the onset of anaphase I in mouse oocytes.	PRKCA PRKCB	6.70e-06	5	29	2	15229137
Pubmed	Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.	PRKCA PRKCB	6.70e-06	5	29	2	1321150
Pubmed	Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.	PRKCA PRKCB	6.70e-06	5	29	2	28228266
Pubmed	Protein kinase C regulates the phosphorylation and cellular localization of occludin.	PRKCA PRKCB	6.70e-06	5	29	2	11502742
Pubmed	PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.	PRKCA PRKCB	6.70e-06	5	29	2	23824069
Pubmed	IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.	PRKCA PRKCB	6.70e-06	5	29	2	15488737
Pubmed	Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.	PRKCA PRKCB	6.70e-06	5	29	2	9030777
Pubmed	betaII protein kinase C is required for the G2/M phase transition of cell cycle.	PRKCA PRKCB	6.70e-06	5	29	2	8663071
Pubmed	PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K+ channel activity by mutant α1B-adrenergic receptors.	PRKCA PRKCB	6.70e-06	5	29	2	34958868
Pubmed	Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.	PRKCA PRKCB	6.70e-06	5	29	2	12519779
Pubmed	Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.	PRKCA PRKCB	6.70e-06	5	29	2	20392936
Pubmed	Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.	PRKCA PRKCB	1.00e-05	6	29	2	25313067
Pubmed	Specific protein kinase C isoforms are required for rod photoreceptor differentiation.	PRKCA PRKCB	1.00e-05	6	29	2	22171059
Pubmed	Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.	PRKCA PRKCB	1.00e-05	6	29	2	21190563
Pubmed	An immunohistochemical study of protein kinase C distribution in fetal mouse vertebral column.	PRKCA PRKCB	1.00e-05	6	29	2	7985811
Pubmed	Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts.	PRKCA PRKCB	1.00e-05	6	29	2	12782152
Pubmed	Protein kinase C isoform expression and activity in the mouse heart.	PRKCA PRKCB	1.00e-05	6	29	2	11668067
Pubmed	Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations.	PRKCA PRKCB	1.00e-05	6	29	2	20815813
Pubmed	Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.	PRKCA PRKCB	1.00e-05	6	29	2	11306676
Pubmed	Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.	PRKCA PRKCB	1.00e-05	6	29	2	15632189
Cytoband	3p22.2	DCLK3 SCN11A	1.05e-04	24	29	2	3p22.2
GeneFamily	C2 domain containing protein kinases	PRKCA PRKCB	8.20e-05	10	25	2	835
GeneFamily	PHD finger proteins	TRIM66 PHF10	6.82e-03	90	25	2	88
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ROCK2 SOS1	3.26e-02	206	25	2	682
Drug	12-hydroxydaphnetoxin	PRKCA PRKCB	1.57e-06	2	29	2	CID000099841
Drug	methoxamine	ROCK2 PRKCA PRKCB ADCY5	1.94e-06	71	29	4	CID000006081
Drug	octahydromezerein	PRKCA PRKCB	4.70e-06	3	29	2	CID000164152
Drug	daphnetoxin	PRKCA PRKCB	9.38e-06	4	29	2	CID000119454
Drug	AC1NSKHR	ROCK2 PRKCA PRKCB	1.08e-05	34	29	3	CID005311362
Drug	12-deoxyphorbolphenylacetate-20-acetate	PRKCA PRKCB	1.56e-05	5	29	2	ctd:C029705
Drug	12-deoxyphorbol 13-isobutyrate	ROCK2 PRKCA PRKCB	1.65e-05	39	29	3	CID000107855
Drug	thymeleatoxin	PRKCA PRKCB	2.34e-05	6	29	2	ctd:C080287
Drug	ruboxistaurin	PRKCA PRKCB	2.34e-05	6	29	2	ctd:C099154
Drug	(S)-1,2-Diolein	CKAP5 PRKCA PRKCB	3.50e-05	50	29	3	CID000001324
Drug	lead compounds	PRKCA PRKCB ADCY5 ANAPC2	3.78e-05	150	29	4	CID000073212
Drug	nM-1	ROCK2 PRKCA PRKCB ADCY5	4.30e-05	155	29	4	CID000445754
Drug	GGTI-297	ROCK2 PRKCA	4.37e-05	8	29	2	CID009956145
Drug	GDP-b-S	ROCK2 PRKCA PRKCB ADCY5	5.11e-05	162	29	4	CID000643998
Drug	aescine	ROCK2 PRKCA PRKCB	6.05e-05	60	29	3	CID004555259
Drug	sn-glycero-3-phosphoserine	PRKCA PRKCB	7.00e-05	10	29	2	CID000444182
Drug	Vitamin E	PRKCA PRKCB	7.00e-05	10	29	2	DB00163
Drug	puerarin	UBAP1 PRKCA PRKCB	7.01e-05	63	29	3	CID005281807
Drug	AC1L9HHR	ZNRF1 S100A10 PRKCA PRKCB ADCY5	7.72e-05	354	29	5	CID000445141
Drug	Phosphatidylserines	PRKCA PRKCB	8.55e-05	11	29	2	ctd:D010718
Drug	KT5720	ROCK2 PRKCA PRKCB ADCY5	9.29e-05	189	29	4	CID000003844
Drug	ONO-RS-082	ROCK2 PRKCA PRKCB	9.60e-05	70	29	3	CID006438389
Drug	bryostatin 1	PRKCA PRKCB	1.03e-04	12	29	2	ctd:C046785
Drug	AC1L1JVU	ROCK2 PRKCA PRKCB	1.04e-04	72	29	3	CID000005229
Drug	glibenclamide	ROCK2 PRKCA PRKCB ABCA12 ADCY5	1.10e-04	382	29	5	CID000003488
Drug	AC1L1B9H	PRKCA PRKCB ADCY5	1.33e-04	78	29	3	CID000001341
Drug	Fura-2AM	ROCK2 PRKCA PRKCB	1.38e-04	79	29	3	CID000105091
Drug	Pc 12	PRKCA PRKCB DUS4L SOS1	1.42e-04	211	29	4	CID003036508
Drug	1 Em	PRKCA PRKCB ADCY5	1.59e-04	83	29	3	CID000446621
Drug	RK-1409B	PRKCA PRKCB	1.63e-04	15	29	2	CID003036125
Drug	dansyl-DAG	PRKCA PRKCB	1.63e-04	15	29	2	CID000129493
Drug	1-stearoyl-2-arachidonylglycerol	PRKCA PRKCB	1.63e-04	15	29	2	CID006443869
Drug	1uu9	PRKCA PRKCB	1.86e-04	16	29	2	CID000002398
Drug	tert-Butyl Alcohol	PRKCA PRKCB	1.86e-04	16	29	2	ctd:D020002
Drug	AC1O517G	PRKCA PRKCB	1.86e-04	16	29	2	CID006450188
Drug	tetradotoxin	ROCK2 S100A10 PRKCA PRKCB SCN11A	1.88e-04	428	29	5	CID000020382
Drug	tetracaine	PRKCA PRKCB ADCY5	1.90e-04	88	29	3	CID000005411
Drug	diphenyleneiodonium	ROCK2 PRKCA PRKCB UQCRC1	2.04e-04	232	29	4	CID000003101
Drug	Ct-15	PRKCA PRKCB	2.11e-04	17	29	2	CID003034917
Drug	daphnoretin	PRKCA PRKCB	2.11e-04	17	29	2	CID005281406
Drug	AC1L1JQC	PRKCA PRKCB	2.11e-04	17	29	2	CID000005157
Drug	AT-8	PRKCA PRKCB	2.11e-04	17	29	2	CID000025566
Drug	1,3-DCG	PRKCA PRKCB ADCY5	2.30e-04	94	29	3	CID000150911
Drug	dipalmitin	PRKCA PRKCB	2.37e-04	18	29	2	CID000068149
Drug	Cgp-42700	PRKCA PRKCB	2.37e-04	18	29	2	CID000188390
Drug	dihydrosterculic acid	PRKCA PRKCB	2.37e-04	18	29	2	CID000160788
Drug	quin2	PRKCA PRKCB ADCY5	2.38e-04	95	29	3	CID000104841
Drug	Bq123	ROCK2 PRKCA PRKCB	2.38e-04	95	29	3	CID000443289
Drug	lead chromate	CKAP5 PRKCA PRKCB	2.60e-04	98	29	3	CID000024460
Drug	TAPP-Br	PRKCA PRKCB	2.64e-04	19	29	2	CID000160326
Drug	sapintoxin A	PRKCA PRKCB	2.64e-04	19	29	2	CID000108085
Drug	SR121463	PRKCA PRKCB	2.64e-04	19	29	2	CID000158348
Drug	diethylaminoethanol	UBAP1 SCN11A	2.64e-04	19	29	2	CID000007497
Drug	PDBu	ROCK2 PRKCA PRKCB ADCY5	2.67e-04	249	29	4	CID000037783
Drug	W7 hydrochloride	ROCK2 PRKCA PRKCB ADCY5	2.72e-04	250	29	4	CID000005681
Drug	4 alpha-phorbol	ROCK2 PRKCA PRKCB	3.02e-04	103	29	3	CID000028683
Drug	Ro 31-8830	ROCK2 PRKCA PRKCB	3.10e-04	104	29	3	CID000005084
Drug	KS-619-1	PRKCA PRKCB	3.24e-04	21	29	2	CID000128369
Drug	K-259-2	PRKCA PRKCB	3.24e-04	21	29	2	CID006438946
Drug	debromoaplysiatoxin	PRKCA PRKCB	3.24e-04	21	29	2	CID000002967
Drug	broussochalcone A	PRKCA PRKCB	3.24e-04	21	29	2	CID006438825
Drug	ALT-711	PRKCA PRKCB	3.24e-04	21	29	2	CID000216304
Drug	MDL 27,032	PRKCA PRKCB	3.24e-04	21	29	2	CID000163812
Drug	20-HETE	ROCK2 PRKCA PRKCB	3.28e-04	106	29	3	CID005283157
Drug	hypericin	PRKCA PRKCB UQCRC1	3.47e-04	108	29	3	CID005281051
Drug	HA1004	PRKCA PRKCB ADCY5	3.56e-04	109	29	3	CID000003546
Drug	1-aminocyclopentane-1,3-dicarboxylate	PRKCA PRKCB ADCY5	3.76e-04	111	29	3	CID000001310
Drug	L-656,224	PRKCA PRKCB	3.90e-04	23	29	2	CID000128132
Drug	AC1L4NFY	PRKCA PRKCB	3.90e-04	23	29	2	CID000160335
Drug	Quinpirole	ROCK2 ADCY5	4.25e-04	24	29	2	ctd:D019257
Drug	tyrphostin 23	ROCK2 PRKCA PRKCB	4.27e-04	116	29	3	CID000002052
Drug	H-8105	ROCK2 PRKCA PRKCB ADCY5	4.29e-04	282	29	4	CID000164531
Drug	DPCPX	PRKCA PRKCB ADCY5	4.38e-04	117	29	3	CID000001329
Drug	U46619	ROCK2 PRKCA PRKCB ADCY5	4.46e-04	285	29	4	CID000005618
Drug	tautomycin	ROCK2 PRKCA PRKCB	4.49e-04	118	29	3	CID000440646
Drug	BAPTA-AM	ROCK2 PRKCA PRKCB ADCY5	4.95e-04	293	29	4	CID000002293
Drug	C2-ceramide	PRKCA PRKCB UQCRC1 ADNP	5.02e-04	294	29	4	CID000002505
Drug	lithium chromate	PRKCA PRKCB ABCA12 ADCY5	5.14e-04	296	29	4	CID000026627
Drug	thiram	PRKCA PRKCB	5.39e-04	27	29	2	CID000005455
Drug	beta-tocopherol	PRKCA PRKCB	5.39e-04	27	29	2	CID000008989
Drug	IBDU	PRKCA PRKCB	5.39e-04	27	29	2	CID000022478
Drug	ilmofosine	PRKCA PRKCB	5.39e-04	27	29	2	CID000055008
Drug	pseudohypericin	PRKCA PRKCB	5.39e-04	27	29	2	CID005281751
Drug	C15720	PRKCA PRKCB	5.39e-04	27	29	2	CID000003979
Drug	AC1OAGFB	ROCK2 PRKCA PRKCB ADCY5 SOS1	5.42e-04	539	29	5	CID006857345
Drug	AC1L1DKK	ROCK2 PRKCA PRKCB	5.57e-04	127	29	3	CID000002390
Drug	2-aminoethyl diphenylborinate	ROCK2 PRKCA PRKCB	5.57e-04	127	29	3	CID000001598
Drug	bisindolylmaleimide II	PRKCA PRKCB	5.80e-04	28	29	2	CID000002397
Drug	bisindolylmaleimide V	PRKCA PRKCB	5.80e-04	28	29	2	CID000002400
Drug	aplysiatoxin	PRKCA PRKCB	5.80e-04	28	29	2	CID000040465
Drug	HBDDE	PRKCA PRKCB	5.80e-04	28	29	2	CID000003568
Drug	SC-10	PRKCA PRKCB	5.80e-04	28	29	2	CID000005175
Drug	NCDC	PRKCA PRKCB	5.80e-04	28	29	2	CID000001583
Drug	dibutyryl cyclic GMP	PRKCA PRKCB ADCY5	5.96e-04	130	29	3	CID000036095
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	ROCK2 PRKCA PRKCB ADCY5	5.97e-04	308	29	4	CID000001915
Drug	phloretin	PRKCA PRKCB PPM1K	6.10e-04	131	29	3	CID000004788
Drug	serotonin	ROCK2 PRKCA PRKCB SCN11A ADCY5	6.13e-04	554	29	5	CID000005202
Drug	AC1Q6DXY	PRKCA PRKCB	6.23e-04	29	29	2	CID000003719
Drug	Polychlorinated biphenyls	PRKCA PRKCB	6.23e-04	29	29	2	CID000006636
Drug	AC1L1B58	PRKCA PRKCB	6.23e-04	29	29	2	CID000001288
Disease	polycystic ovary syndrome, fasting blood glucose measurement	CKAP5 ADCY5	2.60e-06	3	28	2	EFO_0000660, EFO_0004465
Disease	Cardiac Hypertrophy	ROCK2 PRKCA PRKCB	6.44e-05	82	28	3	C1383860
Disease	Cardiomegaly	ROCK2 PRKCA PRKCB	6.44e-05	82	28	3	C0018800
Disease	Adenocarcinoma of large intestine	DCLK3 PRKCA PRKCB	1.03e-04	96	28	3	C1319315
Disease	gestational age, parental genotype effect measurement	ADCY5 SOS1	5.07e-04	35	28	2	EFO_0005112, EFO_0005939
Disease	dilated cardiomyopathy (is_implicated_in)	PRKCA PRKCB	7.65e-04	43	28	2	DOID:12930 (is_implicated_in)
Disease	alcohol use disorder (implicated_via_orthology)	PRKCA PRKCB PHF10	8.24e-04	195	28	3	DOID:1574 (implicated_via_orthology)
Disease	PR interval	MKLN1 PRKCA ABCA12 ADCY5	1.16e-03	495	28	4	EFO_0004462
Disease	plasminogen activator inhibitor 1 measurement	IFFO2 UBAP1	1.21e-03	54	28	2	EFO_0004792
Disease	Major Depressive Disorder	S100A10 PRKCB ADCY5	1.55e-03	243	28	3	C1269683
Disease	Unipolar Depression	S100A10 PRKCB ADCY5	1.86e-03	259	28	3	C0041696

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNDVEKMAAHMRMVH	ADNP	521	Q9H2P0
KMAAHMRMVHIDEEM	ADNP	526	Q9H2P0
EAPMHFCEVMLKDMA	ANAPC2	551	Q9UJX6
LHEYMKMMGVNSCSH	ABCA12	1096	Q86UK0
ADHAHCCVEMGMDMI	ADCY5	531	O95622
AHEKICMLTFEHEME	MKRN2	211	Q9H000
DFCHTHMEKCIMDLL	PPM1K	136	Q8N3J5
HTCLMMDMKACQEDD	INTS3	721	Q68E01
AVMLKEMMEQNCAHS	FANCM	1646	Q8IYD8
LMIMDLCKALVHMHD	DCLK3	456	Q9C098
IHQGMKCDTCMMNVH	PRKCB	126	P05771
AHFVCDRMKIDDMMF	UQCRC1	356	P31930
QPHHEEEMMFCDMCD	PHF10	441	Q8WUB8
EAHLCRMMKHSMDQT	CKAP5	1791	Q14008
HMERKMSAMACEIFN	KLHL10	16	Q6JEL2
KSDMNRHLHEYMEMC	IFFO2	446	Q5TF58
MCFHQHLMYMMEKIT	DUS4L	276	O95620
SGVMSEKDHMVTMHD	DKC1	251	O60832
FEQASHMMKLIEEHC	LINC00597	11	Q9H2U6
HIKIADFGMCKEHMM	PRKCA	476	P17252
LVFDHQMCMDSEKHM	MKLN1	386	Q9UL63
MCADKVLMDMFHQDV	SOS1	166	Q07889
EHAMETMMFTFHKFA	S100A10	6	P60903
KTDEMHTALMEACMD	ANKHD1	401	Q8IWZ3
ALEMHQCSEEKMMEF	UBAP1	446	Q9NZ09
CMKMDETGMVHCDTA	ROCK2	236	O75116
MEHHKMEASFEKMLN	SCN11A	596	Q9UI33
CSQNMDIMHHKFELE	TRIM66	501	O15016
SVASDEMEMHFIMCL	ZNRF1	151	Q8ND25
DHMMDAIARCEQMAQ	MYO7B	1256	Q6PIF6