Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	GMPR GMPR2	1.59e-05	2	80	2	GO:0046857
GeneOntologyMolecularFunction	GMP reductase activity	GMPR GMPR2	1.59e-05	2	80	2	GO:0003920
GeneOntologyMolecularFunction	calcium ion binding	JAG2 SNED1 EYS SCUBE1 PLA2G2D ACAN SCUBE3 MATN4 EGFLAM LTBP3 EGFL8 LRP8	4.12e-05	749	80	12	GO:0005509
GeneOntologyMolecularFunction	extracellular matrix structural constituent	TNC ACAN MATN4 MUC2 SSPOP IMPG2	1.08e-04	188	80	6	GO:0005201
GeneOntologyMolecularFunction	syndecan binding	TNC SEMA5A	5.60e-04	9	80	2	GO:0045545
GeneOntologyMolecularFunction	glycosaminoglycan binding	RSPO3 PLA2G2D ACAN SEMA5A EGFLAM IMPG2	7.24e-04	268	80	6	GO:0005539
GeneOntologyMolecularFunction	proteoglycan binding	PLA2G2D TNC SEMA5A	1.12e-03	51	80	3	GO:0043394
GeneOntologyBiologicalProcess	IMP biosynthetic process	ADSL GMPR GMPR2	2.47e-05	15	80	3	GO:0006188
GeneOntologyBiologicalProcess	purine ribonucleotide salvage	ADSL GMPR GMPR2	3.03e-05	16	80	3	GO:0106380
GeneOntologyBiologicalProcess	purine nucleotide salvage	ADSL GMPR GMPR2	5.21e-05	19	80	3	GO:0032261
GeneOntologyBiologicalProcess	purine-containing compound salvage	ADSL GMPR GMPR2	8.20e-05	22	80	3	GO:0043101
GeneOntologyBiologicalProcess	purine ribonucleoside monophosphate biosynthetic process	ADSL GMPR GMPR2	9.41e-05	23	80	3	GO:0009168
GeneOntologyBiologicalProcess	IMP metabolic process	ADSL GMPR GMPR2	1.07e-04	24	80	3	GO:0046040
GeneOntologyBiologicalProcess	detection of light stimulus involved in visual perception	EYS SEMA5B SEMA5A	1.22e-04	25	80	3	GO:0050908
GeneOntologyBiologicalProcess	detection of light stimulus involved in sensory perception	EYS SEMA5B SEMA5A	1.22e-04	25	80	3	GO:0050962
GeneOntologyBiologicalProcess	purine nucleoside monophosphate biosynthetic process	ADSL GMPR GMPR2	1.22e-04	25	80	3	GO:0009127
GeneOntologyBiologicalProcess	nucleotide salvage	ADSL GMPR GMPR2	1.37e-04	26	80	3	GO:0043173
GeneOntologyCellularComponent	extracellular matrix	SNED1 EYS FCGBP ZAN ADAMTS6 TNC ACAN MATN4 EGFLAM LTBP3 RTBDN MUC2 SSPOP OTOG IMPG2	2.87e-08	656	81	15	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	SNED1 EYS FCGBP ZAN ADAMTS6 TNC ACAN MATN4 EGFLAM LTBP3 RTBDN MUC2 SSPOP OTOG IMPG2	2.99e-08	658	81	15	GO:0030312
GeneOntologyCellularComponent	interphotoreceptor matrix	EYS RTBDN IMPG2	1.11e-06	6	81	3	GO:0033165
GeneOntologyCellularComponent	GMP reductase complex	GMPR GMPR2	1.48e-05	2	81	2	GO:1902560
GeneOntologyCellularComponent	collagen-containing extracellular matrix	EYS TNC ACAN MATN4 EGFLAM LTBP3 RTBDN MUC2 SSPOP IMPG2	3.77e-05	530	81	10	GO:0062023
GeneOntologyCellularComponent	perisynaptic extracellular matrix	TNC ACAN	7.97e-04	11	81	2	GO:0098966
GeneOntologyCellularComponent	synapse-associated extracellular matrix	TNC ACAN	1.13e-03	13	81	2	GO:0099535
GeneOntologyCellularComponent	interstitial matrix	TNC EGFLAM	1.94e-03	17	81	2	GO:0005614
Domain	EGF_3	JAG2 SNED1 EYS SCUBE1 NTNG2 ZAN TNC SCUBE3 ADAM33 MATN4 EGFLAM LTBP3 EGFL8 SSPOP MEGF11 OTOG IMPG2 LRP8	4.52e-18	235	79	18	PS50026
Domain	EGF-like_dom	JAG2 SNED1 EYS SCUBE1 NTNG2 FCGBP ZAN TNC SCUBE3 ADAM33 MATN4 EGFLAM LTBP3 EGFL8 MEGF11 OTOG IMPG2 LRP8	1.27e-17	249	79	18	IPR000742
Domain	EGF_1	JAG2 SNED1 EYS SCUBE1 NTNG2 ZAN TNC SCUBE3 ADAM33 MATN4 EGFLAM LTBP3 EGFL8 SSPOP ITGB7 MEGF11 IMPG2 LRP8	1.95e-17	255	79	18	PS00022
Domain	EGF_2	JAG2 SNED1 EYS SCUBE1 NTNG2 ZAN TNC SCUBE3 ADAM33 MATN4 EGFLAM LTBP3 EGFL8 SSPOP ITGB7 MEGF11 IMPG2 LRP8	3.87e-17	265	79	18	PS01186
Domain	EGF	JAG2 RSPO3 SNED1 EYS SCUBE1 NTNG2 FCGBP ZAN TNC SCUBE3 ADAM33 MATN4 EGFLAM LTBP3 EGFL8 MEGF11 LRP8	1.11e-16	235	79	17	SM00181
Domain	EGF-like_CS	JAG2 SNED1 EYS SCUBE1 NTNG2 ZAN TNC SCUBE3 ADAM33 MATN4 EGFLAM LTBP3 EGFL8 ITGB7 MEGF11 IMPG2 LRP8	6.46e-16	261	79	17	IPR013032
Domain	EGF	JAG2 SNED1 EYS NTNG2 ZAN TNC SCUBE3 MATN4 EGFLAM EGFL8 LRP8	5.18e-12	126	79	11	PF00008
Domain	Growth_fac_rcpt_	JAG2 RSPO3 EYS ERBB4 SCUBE1 TNC INSRR SCUBE3 MATN4 LTBP3 LRP8	5.37e-11	156	79	11	IPR009030
Domain	EGF_CA	JAG2 SNED1 EYS SCUBE1 SCUBE3 MATN4 EGFLAM LTBP3 EGFL8 LRP8	9.59e-11	122	79	10	SM00179
Domain	EGF-like_Ca-bd_dom	JAG2 SNED1 EYS SCUBE1 SCUBE3 MATN4 EGFLAM LTBP3 EGFL8 LRP8	1.13e-10	124	79	10	IPR001881
Domain	VWC_out	JAG2 FCGBP ZAN MUC2 SSPOP OTOG	1.23e-10	19	79	6	SM00215
Domain	ASX_HYDROXYL	JAG2 SNED1 EYS SCUBE1 SCUBE3 MATN4 LTBP3 EGFL8 LRP8	3.78e-10	100	79	9	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	JAG2 SNED1 EYS SCUBE1 SCUBE3 MATN4 LTBP3 EGFL8 LRP8	6.40e-10	106	79	9	IPR000152
Domain	TIL	FCGBP ZAN MUC2 SSPOP OTOG	9.21e-10	12	79	5	PF01826
Domain	C8	FCGBP ZAN MUC2 SSPOP OTOG	9.21e-10	12	79	5	PF08742
Domain	Unchr_dom_Cys-rich	FCGBP ZAN MUC2 SSPOP OTOG	1.49e-09	13	79	5	IPR014853
Domain	C8	FCGBP ZAN MUC2 SSPOP OTOG	1.49e-09	13	79	5	SM00832
Domain	TIL_dom	FCGBP ZAN MUC2 SSPOP OTOG	2.31e-09	14	79	5	IPR002919
Domain	VWD	FCGBP ZAN MUC2 SSPOP OTOG	5.01e-09	16	79	5	SM00216
Domain	VWF_type-D	FCGBP ZAN MUC2 SSPOP OTOG	5.01e-09	16	79	5	IPR001846
Domain	VWFD	FCGBP ZAN MUC2 SSPOP OTOG	5.01e-09	16	79	5	PS51233
Domain	VWD	FCGBP ZAN MUC2 SSPOP OTOG	5.01e-09	16	79	5	PF00094
Domain	EGF_Ca-bd_CS	JAG2 SNED1 EYS SCUBE1 SCUBE3 LTBP3 EGFL8 LRP8	7.61e-09	97	79	8	IPR018097
Domain	EGF_CA	JAG2 SNED1 EYS SCUBE1 SCUBE3 LTBP3 EGFL8 LRP8	8.95e-09	99	79	8	PS01187
Domain	VWF_dom	JAG2 FCGBP ZAN MUC2 SSPOP OTOG	2.19e-08	42	79	6	IPR001007
Domain	EGF_CA	JAG2 SCUBE1 SCUBE3 MATN4 LTBP3 EGFL8 LRP8	7.59e-08	86	79	7	PF07645
Domain	hEGF	JAG2 SNED1 EYS LTBP3 MEGF11	1.08e-07	28	79	5	PF12661
Domain	EGF_extracell	JAG2 NTNG2 TNC ADAM33 ITGB7 MEGF11	1.97e-07	60	79	6	IPR013111
Domain	EGF_2	JAG2 NTNG2 TNC ADAM33 ITGB7 MEGF11	1.97e-07	60	79	6	PF07974
Domain	TSP_1	RSPO3 SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	2.65e-07	63	79	6	PF00090
Domain	TSP1	RSPO3 SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	3.20e-07	65	79	6	SM00209
Domain	TSP1_rpt	RSPO3 SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	3.20e-07	65	79	6	IPR000884
Domain	TSP1	RSPO3 SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	3.20e-07	65	79	6	PS50092
Domain	VWC	JAG2 FCGBP ZAN MUC2 SSPOP	5.36e-07	38	79	5	SM00214
Domain	cEGF	SCUBE1 SCUBE3 MATN4 LTBP3	4.13e-06	26	79	4	IPR026823
Domain	cEGF	SCUBE1 SCUBE3 MATN4 LTBP3	4.13e-06	26	79	4	PF12662
Domain	VWFC_1	JAG2 ZAN MUC2 SSPOP	1.58e-05	36	79	4	PS01208
Domain	GMPR	GMPR GMPR2	1.77e-05	2	79	2	IPR005993
Domain	VWFC_2	JAG2 ZAN MUC2 SSPOP	1.96e-05	38	79	4	PS50184
Domain	EMI	EGFL8 SSPOP MEGF11	4.75e-05	17	79	3	PS51041
Domain	TILa	FCGBP ZAN	5.29e-05	3	79	2	PF12714
Domain	TILa_dom	FCGBP ZAN	5.29e-05	3	79	2	IPR025615
Domain	Furin_repeat	RSPO3 ERBB4 INSRR	5.68e-05	18	79	3	IPR006212
Domain	FU	RSPO3 ERBB4 INSRR	5.68e-05	18	79	3	SM00261
Domain	IMPDH	GMPR GMPR2	1.05e-04	4	79	2	PF00478
Domain	IMP_DH_GMPRt	GMPR GMPR2	1.05e-04	4	79	2	IPR001093
Domain	IMP_DH_GMP_RED	GMPR GMPR2	1.05e-04	4	79	2	PS00487
Domain	IMP_DH/GMP_Rdtase_CS	GMPR GMPR2	1.05e-04	4	79	2	IPR015875
Domain	Cys_knot_C	MUC2 SSPOP OTOG	1.57e-04	25	79	3	IPR006207
Domain	CTCK_2	MUC2 SSPOP OTOG	1.57e-04	25	79	3	PS01225
Domain	MANSC_N	KIAA0319 SPINT1	1.75e-04	5	79	2	IPR011106
Domain	MANEC	KIAA0319 SPINT1	1.75e-04	5	79	2	SM00765
Domain	ArfGap	AGAP5 AGAP9 AGAP3	2.46e-04	29	79	3	SM00105
Domain	ArfGap	AGAP5 AGAP9 AGAP3	2.46e-04	29	79	3	PF01412
Domain	ARFGAP	AGAP5 AGAP9 AGAP3	2.46e-04	29	79	3	PS50115
Domain	ArfGAP	AGAP5 AGAP9 AGAP3	2.46e-04	29	79	3	IPR001164
Domain	MANSC_dom	KIAA0319 SPINT1	2.62e-04	6	79	2	IPR013980
Domain	MANSC	KIAA0319 SPINT1	2.62e-04	6	79	2	PS50986
Domain	Furin-like	ERBB4 INSRR	3.66e-04	7	79	2	PF00757
Domain	Rcpt_L-dom	ERBB4 INSRR	3.66e-04	7	79	2	IPR000494
Domain	Furin-like_Cys-rich_dom	ERBB4 INSRR	3.66e-04	7	79	2	IPR006211
Domain	Recep_L_domain	ERBB4 INSRR	3.66e-04	7	79	2	PF01030
Domain	-	ERBB4 INSRR	3.66e-04	7	79	2	3.80.20.20
Domain	LDLR_class-A_CS	SPINT1 SSPOP LRP8	6.43e-04	40	79	3	IPR023415
Domain	PSI	SEMA5B SEMA5A ITGB7	8.51e-04	44	79	3	IPR016201
Domain	Ldl_recept_a	SPINT1 SSPOP LRP8	9.09e-04	45	79	3	PF00057
Domain	Fol_N	SNED1 FCGBP	9.48e-04	11	79	2	IPR003645
Domain	Ephrin_rec_like	SCUBE1 SCUBE3	9.48e-04	11	79	2	PF07699
Domain	Laminin_G_1	EYS EGFLAM	9.48e-04	11	79	2	PF00054
Domain	FOLN	SNED1 FCGBP	9.48e-04	11	79	2	SM00274
Domain	PSI	SEMA5B SEMA5A ITGB7	9.70e-04	46	79	3	SM00423
Domain	-	SPINT1 SSPOP LRP8	9.70e-04	46	79	3	4.10.400.10
Domain	LDLRA_1	SPINT1 SSPOP LRP8	1.10e-03	48	79	3	PS01209
Domain	FN3	KIAA0319 SNED1 TNC INSRR EGFLAM	1.13e-03	185	79	5	SM00060
Domain	EGF_3	SCUBE1 SCUBE3	1.13e-03	12	79	2	PF12947
Domain	EGF_dom	SCUBE1 SCUBE3	1.13e-03	12	79	2	IPR024731
Domain	LDLRA_2	SPINT1 SSPOP LRP8	1.17e-03	49	79	3	PS50068
Domain	LDrepeatLR_classA_rpt	SPINT1 SSPOP LRP8	1.17e-03	49	79	3	IPR002172
Domain	LDLa	SPINT1 SSPOP LRP8	1.17e-03	49	79	3	SM00192
Domain	FN3_dom	KIAA0319 SNED1 TNC INSRR EGFLAM	1.93e-03	209	79	5	IPR003961
Domain	EMI_domain	EGFL8 MEGF11	2.04e-03	16	79	2	IPR011489
Domain	CTCK_1	MUC2 SSPOP	2.59e-03	18	79	2	PS01185
Domain	Semaphorin	SEMA5B SEMA5A	3.19e-03	20	79	2	IPR027231
Domain	CT	MUC2 OTOG	3.86e-03	22	79	2	SM00041
Domain	-	CLIP3 AGAP5 PLA2G6 AGAP9 AGAP3	4.02e-03	248	79	5	1.25.40.20
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	3.91e-07	39	55	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	3.91e-07	39	55	5	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	SEMA5B ADAMTS6 SEMA5A THSD7B MUC2 SSPOP	3.96e-06	109	55	6	MM15164
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	6.49e-06	68	55	5	M27303
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	SEMA5B ADAMTS6 ACAN SEMA5A THSD7B SSPOP	1.89e-05	143	55	6	M27275
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	SCUBE1 TNC ACAN SCUBE3 MATN4 LTBP3 ITGB7	6.08e-05	258	55	7	MM14572
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	7.03e-05	111	55	5	M27416
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	SCUBE1 TNC ACAN SCUBE3 MATN4 LTBP3 ITGB7	1.56e-04	300	55	7	M610
Pathway	REACTOME_MET_RECEPTOR_ACTIVATION	HGF SPINT1	2.22e-04	6	55	2	M27644
Pathway	REACTOME_MET_RECEPTOR_ACTIVATION	HGF SPINT1	2.22e-04	6	55	2	MM15346
Pathway	REACTOME_DISEASES_OF_METABOLISM	SEMA5B ADAMTS6 ACAN SEMA5A THSD7B SSPOP	4.10e-04	250	55	6	M27554
Pathway	REACTOME_ECM_PROTEOGLYCANS	TNC ACAN MATN4	8.07e-04	47	55	3	MM14925
Pathway	REACTOME_PURINE_SALVAGE	GMPR GMPR2	1.13e-03	13	55	2	MM15438
Pathway	REACTOME_PURINE_SALVAGE	GMPR GMPR2	1.13e-03	13	55	2	M814
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	SEMA5B ADAMTS6 SEMA5A THSD7B SSPOP	9.18e-07	75	81	5	20637190
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP9 AGAP3	1.01e-06	9	81	3	12640130
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP9 AGAP3	1.98e-06	11	81	3	15381706
Pubmed	The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain.	SNED1 AFP ACAN MATN4	3.78e-06	45	81	4	34248495
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	ERBB4 INSRR ITGB7 IMPG2 LRP8	4.02e-06	101	81	5	23382219
Pubmed	Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.	FCGBP MUC2	5.36e-06	2	81	2	19432394
Pubmed	Regulation of arachidonic acid availability for eicosanoid production.	PLA2G2D PLA2G6	5.36e-06	2	81	2	15052324
Pubmed	Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac.	HGF TNC	5.36e-06	2	81	2	15059978
Pubmed	A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones.	SCUBE1 SCUBE3	5.36e-06	2	81	2	15234972
Pubmed	The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.	FCGBP MUC2	5.36e-06	2	81	2	34126068
Pubmed	Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators.	GMPR GMPR2	5.36e-06	2	81	2	218932
Pubmed	Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis?	SCUBE1 SCUBE3	5.36e-06	2	81	2	28238185
Pubmed	Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.	TNC ACAN	5.36e-06	2	81	2	7524681
Pubmed	Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer.	TNC MUC2	5.36e-06	2	81	2	29999571
Pubmed	NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.	GMPR GMPR2	5.36e-06	2	81	2	12009299
Pubmed	Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry.	PLA2G2D PLA2G6	1.60e-05	3	81	2	23533611
Pubmed	The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.	SCUBE1 SCUBE3	1.60e-05	3	81	2	31991528
Pubmed	TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.	HGF SPINT1	1.60e-05	3	81	2	20977675
Pubmed	Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.	SCUBE1 SCUBE3	1.60e-05	3	81	2	12270931
Pubmed	Behavioral abnormalities observed in Zfhx2-deficient mice.	ZFHX2 ZFHX3	3.20e-05	4	81	2	23300874
Pubmed	Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.	FCGBP MUC2	3.20e-05	4	81	2	28604600
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	JAG2 MUC2	3.20e-05	4	81	2	22691042
Pubmed	Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression.	AFP ZFHX3	3.20e-05	4	81	2	33368532
Pubmed	Cbl-b deficiency prevents functional but not phenotypic T cell anergy.	RNF128 ZAP70	3.20e-05	4	81	2	33974042
Pubmed	Evaluation of MYOC, ACAN, HGF, and MET as candidate genes for high myopia in a Han Chinese population.	HGF ACAN	3.20e-05	4	81	2	24766640
Pubmed	Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.	HGF SPINT1	3.20e-05	4	81	2	26165838
Pubmed	GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.	RSPO3 HGF TNC	3.82e-05	28	81	3	28218627
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	CNBP TES LPXN ZFHX2 ZFHX3 AIP TACC3 RNF128 PHIP	4.08e-05	709	81	9	22988430
Pubmed	Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants.	SEMA5B ACAN SEMA5A	5.22e-05	31	81	3	24014668
Pubmed	Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.	SCUBE1 SCUBE3	5.33e-05	5	81	2	23383134
Pubmed	Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.	AFP COA5	5.33e-05	5	81	2	36301669
Pubmed	Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.	SEMA5B SEMA5A	5.33e-05	5	81	2	25313870
Pubmed	A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis.	SEMA5B SEMA5A	5.33e-05	5	81	2	8817451
Pubmed	Hepatocyte migration during liver development requires Prox1.	HGF AFP	7.99e-05	6	81	2	10888866
Pubmed	Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein.	SNED1 TNC	1.12e-04	7	81	2	15162516
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SCUBE1 SCUBE3	1.12e-04	7	81	2	25639508
Pubmed	Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis.	TNC ACAN	1.49e-04	8	81	2	17336282
Pubmed	Invariant Sema5A inhibition serves an ensheathing function during optic nerve development.	SEMA5B SEMA5A	1.49e-04	8	81	2	12506007
Pubmed	Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.	ACAN LRP8	1.49e-04	8	81	2	11856531
Pubmed	Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.	ACAN MATN4	1.91e-04	9	81	2	15296947
Pubmed	The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins.	SEMA5B SEMA5A	1.91e-04	9	81	2	8812066
Pubmed	Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system.	SEMA5B SEMA5A	1.91e-04	9	81	2	15743826
Pubmed	Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.	HGF AFP	1.91e-04	9	81	2	10364163
Pubmed	Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway.	TNC ACAN	1.91e-04	9	81	2	18570250
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP9	2.38e-04	10	81	2	20664521
Pubmed	Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.	ACAN MATN4	2.38e-04	10	81	2	16877353
Pubmed	Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.	PLA2G2D PLA2G6	2.38e-04	10	81	2	26828067
Pubmed	Human ALKBH4 interacts with proteins associated with transcription.	TES ZFHX3	2.38e-04	10	81	2	23145062
Pubmed	An essential role in liver development for transcription factor XBP-1.	HGF AFP	2.38e-04	10	81	2	10652269
Pubmed	ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.	ACAN LRP8	2.91e-04	11	81	2	27909010
Pubmed	Matrilin-3 is dispensable for mouse skeletal growth and development.	ACAN MATN4	2.91e-04	11	81	2	14749384
Pubmed	Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.	FCGBP MUC2 PARP12	3.09e-04	56	81	3	20706999
Pubmed	The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.	RSPO3 LRP8	3.48e-04	12	81	2	30146491
Pubmed	The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver.	SPINT1 AFP	3.48e-04	12	81	2	12874218
Pubmed	Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids.	TNC ITGB7	3.48e-04	12	81	2	10090148
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 AGAP9	4.11e-04	13	81	2	27713690
Pubmed	Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.	ZAN UFSP1	4.11e-04	13	81	2	11239002
Pubmed	Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.	CNBP KDM2B ASXL2	4.37e-04	63	81	3	17672918
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	CNBP EYS ERBB4 TNC INSRR LRP8	4.53e-04	420	81	6	28065597
Pubmed	Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.	TNC ACAN	4.79e-04	14	81	2	15760903
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP9	4.79e-04	14	81	2	22453919
Pubmed	Differential gene expression during early murine yolk sac development.	CNBP AFP	4.79e-04	14	81	2	8562047
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CLIP3 AGAP5 TNC ACAN AGAP9 AGAP3	5.12e-04	430	81	6	32581705
Pubmed	Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.	ZFHX3 MEGF11	5.52e-04	15	81	2	31812516
Pubmed	Shox2 function couples neural, muscular and skeletal development in the proximal forelimb.	RSPO3 MATN4	7.12e-04	17	81	2	21156168
Pubmed	Identification of novel SHOX target genes in the developing limb using a transgenic mouse model.	ACAN MATN4	7.12e-04	17	81	2	24887312
Pubmed	Disrupted tenogenesis in masseter as a potential cause of micrognathia.	TNC ACAN	7.12e-04	17	81	2	36257937
Pubmed	TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts.	HGF TNC	8.00e-04	18	81	2	23041440
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS6 ACAN	8.00e-04	18	81	2	35503090
Pubmed	SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.	SCUBE1 SCUBE3	8.00e-04	18	81	2	33308444
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZCCHC4 ZNF776 ZNF792 ZNF441	8.64e-04	181	81	4	37372979
Pubmed	Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage.	SEMA5B SEMA5A	8.93e-04	19	81	2	15051154
Pubmed	HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.	PLA2G2D PLA2G6	8.93e-04	19	81	2	9377118
Pubmed	The protein tyrosine kinase family of the human genome.	ERBB4 INSRR ZAP70	9.78e-04	83	81	3	11114734
Pubmed	Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.	SEMA5B AFP	9.91e-04	20	81	2	15979417
Pubmed	Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.	HGF AFP	9.91e-04	20	81	2	28838957
Pubmed	Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development.	HGF AFP	9.91e-04	20	81	2	11438667
Pubmed	The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes.	AFP MUC2	1.09e-03	21	81	2	21670299
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	SEMA5B SEMA5A	1.09e-03	21	81	2	21835343
Pubmed	SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis.	TNC ACAN	1.09e-03	21	81	2	30021842
Pubmed	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.	TNC ACAN	1.20e-03	22	81	2	27527664
Pubmed	Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts.	RSPO3 ERBB4	1.20e-03	22	81	2	33898448
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	LIG3 ERBB4 CLCN4	1.24e-03	90	81	3	15033168
Pubmed	Detection of genes regulated by Lmx1b during limb dorsalization.	ACAN MATN4	1.31e-03	23	81	2	22417325
Pubmed	Hierarchical organization of cortical and thalamic connectivity.	ERBB4 NTNG2	1.43e-03	24	81	2	31666704
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	SEMA5B TNC SEMA5A LTBP3	1.49e-03	210	81	4	16537572
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	PLA2G2D PLA2G6	1.68e-03	26	81	2	9745929
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZFHX2 ASXL2 THSD7B	1.77e-03	102	81	3	11214970
Pubmed	Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.	ERBB4 ACAN	1.81e-03	27	81	2	25133637
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA5B SEMA5A	1.95e-03	28	81	2	18617019
Pubmed	Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.	TNC OTOG	1.95e-03	28	81	2	22808246
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	JAG2 TNC LTBP3 TACC3 MEGF11 AGAP3	1.99e-03	560	81	6	21653829
Pubmed	Noggin is required for correct guidance of dorsal root ganglion axons.	SEMA5B SEMA5A	2.09e-03	29	81	2	12435358
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	PHIP CFAP410	2.09e-03	29	81	2	21834987
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	EYS NTNG2 SPINT1 SEMA5B PLA2G2D ADAM33 EGFL8 MEGF11	2.09e-03	985	81	8	12975309
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP9 AGAP3	1.48e-05	17	52	3	1291
GeneFamily	ArfGAPs	AGAP5 AGAP9 AGAP3	1.15e-04	33	52	3	395
GeneFamily	Ankyrin repeat domain containing	CLIP3 AGAP5 PLA2G6 AGAP9 AGAP3	6.42e-04	242	52	5	403
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX2 ZFHX3	8.32e-04	15	52	2	529
GeneFamily	Fibronectin type III domain containing	SNED1 TNC INSRR EGFLAM	1.15e-03	160	52	4	555
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA5B SEMA5A	1.49e-03	20	52	2	736
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	CNBP ZCCHC4	2.33e-03	25	52	2	74
GeneFamily	Phospholipases	PLA2G2D PLA2G6	6.49e-03	42	52	2	467
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SNED1 ACAN	1.17e-02	57	52	2	1179
GeneFamily	LIM domain containing	TES LPXN	1.25e-02	59	52	2	1218
GeneFamily	Proteases, serine	TMPRSS12 PRSS48	1.42e-02	63	52	2	738
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF776 ZNF792 MAZ ZFHX2 ZFHX3 ZNF441	1.66e-02	718	52	6	28
Coexpression	NABA_MATRISOME	RSPO3 SNED1 HGF EYS SCUBE1 NTNG2 SEMA5B ADAMTS6 TNC ACAN SCUBE3 SEMA5A ADAM33 MATN4 EGFLAM LTBP3 EGFL8 MUC2 SSPOP MEGF11 OTOG IMPG2	3.62e-13	1026	81	22	M5889
Coexpression	NABA_MATRISOME	RSPO3 SNED1 HGF SCUBE1 NTNG2 SEMA5B ADAMTS6 TNC ACAN SCUBE3 SEMA5A ADAM33 MATN4 EGFLAM LTBP3 EGFL8 MUC2 SSPOP MEGF11 OTOG IMPG2	2.39e-12	1008	81	21	MM17056
Coexpression	NABA_CORE_MATRISOME	RSPO3 SNED1 EYS NTNG2 TNC ACAN MATN4 EGFLAM LTBP3 SSPOP OTOG IMPG2	5.20e-11	275	81	12	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	RSPO3 SNED1 EYS NTNG2 TNC MATN4 EGFLAM LTBP3 SSPOP OTOG	5.15e-10	196	81	10	M3008
Coexpression	NABA_CORE_MATRISOME	RSPO3 SNED1 NTNG2 TNC ACAN MATN4 EGFLAM LTBP3 SSPOP OTOG IMPG2	7.25e-10	270	81	11	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	RSPO3 SNED1 NTNG2 TNC MATN4 EGFLAM LTBP3 SSPOP OTOG	7.96e-09	191	81	9	MM17059
Coexpression	NABA_MATRISOME_ASSOCIATED	HGF SCUBE1 SEMA5B ADAMTS6 SCUBE3 SEMA5A ADAM33 EGFL8 MUC2 MEGF11	9.13e-05	738	81	10	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	HGF SCUBE1 SEMA5B ADAMTS6 SCUBE3 SEMA5A ADAM33 EGFL8 MUC2 MEGF11	1.05e-04	751	81	10	M5885
Coexpression	MARSON_FOXP3_TARGETS_STIMULATED_UP	LPXN KDM2B ZAP70	1.09e-04	30	81	3	M3146
Coexpression	MARSON_FOXP3_TARGETS_STIMULATED_UP	LPXN KDM2B ZAP70	1.09e-04	30	81	3	MM728
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	CCDC125 RSPO3 SNED1 SCUBE1 TES SEMA5B BHLHA9 SCUBE3 MATN4 EGFLAM THSD7B MEGF11	1.10e-04	1074	81	12	M1941
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP3 KCNC2 LPXN SCUBE3 ADAM33 ITGB7	7.32e-07	172	81	6	33c201aaa98acbf1901b6fa6ce0d3ff8012a4d94
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 SEMA5A ADAM33 GMPR THSD7B	8.10e-07	175	81	6	e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-NK_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	EYS LPXN HSD17B2 ITGB7 ZAP70 PYHIN1	8.37e-07	176	81	6	f0c01fc4f9c17c4d724642d9931731eef2b10258
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEMA5B ACAN SEMA5A ADAM33 EGFLAM THSD7B	8.94e-07	178	81	6	066dbc4cc2083c549d98122ed44707127f34d582
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 NTNG2 ADAMTS6 ADAM33 THSD7B MEGF11	1.05e-06	183	81	6	5e361be3ae3fe05098968e58427630127bd12675
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGF SEMA5B ACAN SEMA5A EGFLAM THSD7B	1.19e-06	187	81	6	b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.23e-06	188	81	6	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.31e-06	190	81	6	3f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.31e-06	190	81	6	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.31e-06	190	81	6	e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.43e-06	193	81	6	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RSPO3 CLIP3 SEMA5B TNC SEMA5A EGFLAM	1.61e-06	197	81	6	5fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SNED1 SCUBE1 SCUBE3 EGFLAM LTBP3 THSD7B	1.71e-06	199	81	6	fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RSPO3 CLIP3 TNC SEMA5A ADAM33 EGFLAM	1.71e-06	199	81	6	0cdbedf09ec72734b86ddab3fec562e066afed92
ToppCell	LPS_only-Hematopoietic_Lymphocytic-Lymphocytic_NK/T-T-cells\|LPS_only / Treatment groups by lineage, cell group, cell type	ADSL AIP TACC3 ITGB7 ZAP70 PYHIN1	1.71e-06	199	81	6	bd7f03bef4660c347da5f16db34d91d563908448
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.76e-06	200	81	6	c65e6336725856c4b5f6aeba1cf86a23ec815d34
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.76e-06	200	81	6	117a25b3b9cdbc2e198381350a8362bee25e82e7
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGF EYS ERBB4 KCNC2 ACAN LRP8	1.76e-06	200	81	6	d459e51507bf26865e6e7e04411379ec82a3edf8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_atypical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA5B ADAMTS6 TNC ACAN ITGB7	7.54e-06	148	81	5	b7b5521162effc1024e7c399f690cd86d0b2f750
ToppCell	LPS-IL1RA-Lymphocytic_NKT-T_cells-T-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LPXN TACC3 ITGB7 ZAP70 PYHIN1	1.52e-05	171	81	5	539ea88acc6f948efdeae8b69e5c5ffaee29f1d9
ToppCell	wk_20-22-Mesenchymal-Chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TNC ACAN SCUBE3 ZFHX3 MATN4	1.52e-05	171	81	5	d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCell	LPS-IL1RA-Lymphocytic_NKT-T_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LPXN TACC3 ITGB7 ZAP70 PYHIN1	1.56e-05	172	81	5	0fc692be845d4225ff8b63bf9195724fc8510c2c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 SEMA5A THSD7B MEGF11	1.65e-05	174	81	5	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells-T-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADSL LPXN ITGB7 ZAP70 PYHIN1	1.74e-05	176	81	5	9d4a4dfeebb5a8a0f3ab18c37c8ddc2cd2158575
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADSL LPXN ITGB7 ZAP70 PYHIN1	1.74e-05	176	81	5	bb41e9478373726eb460af764de0277b2d09928e
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADSL LPXN TACC3 ITGB7 PYHIN1	1.74e-05	176	81	5	ea27e18407b8a13e8212830da859efeb8f158690
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADSL LPXN TACC3 ITGB7 PYHIN1	1.74e-05	176	81	5	bfbab3c5b738b3b0b1540f2059d0245fbd8c0031
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADSL LPXN ITGB7 ZAP70 PYHIN1	1.79e-05	177	81	5	f1efd9c3074d5635700fe7fbebf3dd0b1e0a84f1
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNC LPXN RNF128 ITGB7 ZAP70	1.84e-05	178	81	5	888add8935ef3aef9b6693c5698e9d1842e66337
ToppCell	droplet-Skin-nan-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC125 LPXN SSPOP ITGB7 ZAP70	1.84e-05	178	81	5	12d5c6be6cfbf733e3cb02780606b3725eda7d2b
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNC LPXN RNF128 ITGB7 ZAP70	1.84e-05	178	81	5	43eda32af2e5e28a92421612d0a4c21e5427a772
ToppCell	droplet-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC125 LPXN SSPOP ITGB7 ZAP70	1.84e-05	178	81	5	e0769ad06f92423a3cb6c78a61da3ba5bd9b4eae
ToppCell	droplet-Skin-nan-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC125 LPXN SSPOP ITGB7 ZAP70	1.84e-05	178	81	5	11c2ce093b7538518c8d4497dc5b0b4da22bf1a8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	1.89e-05	179	81	5	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS LPXN ITGB7 ZAP70 PYHIN1	1.94e-05	180	81	5	3f0a692ad2823951e0ec23d0452f436c5f5c09c0
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZCCHC4 LPXN RNF128 ITGB7 ZAP70	1.94e-05	180	81	5	b28363626f4d2a552abde3434cc1df2e2121aba5
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZCCHC4 LPXN RNF128 ITGB7 ZAP70	1.94e-05	180	81	5	67b062f2ef7e20f392e00c646f4985c415d40de9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ACAN SEMA5A ADAM33 MEGF11	1.99e-05	181	81	5	70eff83dd85691e977972c660731394d2fcf5cdf
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.05e-05	182	81	5	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.05e-05	182	81	5	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	Pericytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CLIP3 SEMA5B ACAN ADAM33 ZFHX3	2.05e-05	182	81	5	46c213597445b1f4f09dc367f27702d24b201daf
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3-6_VIP_KCTD13\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 SEMA5A ADAM33 THSD7B	2.10e-05	183	81	5	f06c06c75aab55fa8c803665afaa399446aec5af
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 ACAN LRP8	2.10e-05	183	81	5	04d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS LPXN ITGB7 ZAP70 PYHIN1	2.10e-05	183	81	5	c7fedb5b0c1f17b3391ce1c4a6bfca7615c359c5
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.10e-05	183	81	5	6e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.10e-05	183	81	5	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B ACAN SEMA5A MATN4 MEGF11	2.16e-05	184	81	5	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	HGF SEMA5B SEMA5A ZFHX3 EGFLAM	2.16e-05	184	81	5	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G6 MATN4 EGFLAM EGFL8 RNF128	2.16e-05	184	81	5	e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B ACAN SEMA5A MATN4 MEGF11	2.16e-05	184	81	5	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.21e-05	185	81	5	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.21e-05	185	81	5	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO3 HGF CLIP3 SCUBE1 TNC	2.21e-05	185	81	5	f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.21e-05	185	81	5	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO3 HGF CLIP3 SCUBE1 TNC	2.21e-05	185	81	5	40e958511790e84321da5ccf735f9974c06a0263
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO3 HGF CLIP3 SCUBE1 TNC	2.21e-05	185	81	5	5f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell	15-Distal-Immune-Hematopoietic,_T_Cells\|Distal / Age, Tissue, Lineage and Cell class	EYS LPXN ITGB7 ZAP70 PYHIN1	2.21e-05	185	81	5	481e3d3b63f2e5b4783088523c3cf70a461aed27
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGF SEMA5B ACAN SEMA5A EGFLAM	2.27e-05	186	81	5	1e3ab663e4756975db6d802b2c6c054a94a79393
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LPXN ITGB7 ZAP70 IMPG2 PYHIN1	2.27e-05	186	81	5	ed265e52e4f9b6d277b489091ecc2e629436f791
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.33e-05	187	81	5	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 ADAM33 THSD7B MEGF11	2.33e-05	187	81	5	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA5B ACAN SEMA5A EGFLAM OTOG	2.39e-05	188	81	5	0a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCell	LPS_only-Lymphocytic_NKT\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LPXN TACC3 ITGB7 ZAP70 PYHIN1	2.39e-05	188	81	5	bbe65b1c11c88ab62d8485cfc3a913ff9da89aad
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B SEMA5A MATN4 RNF128 MEGF11	2.39e-05	188	81	5	a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B SEMA5A MATN4 RNF128 MEGF11	2.39e-05	188	81	5	c8530c9ff98666c64a94683261af4288cb790a7e
ToppCell	P07-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEMA5B SCUBE3 SEMA5A ADAM33 ZFHX3	2.39e-05	188	81	5	6ec22b79b19d57ea187f312907819dc2d01f3efe
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO3 SNED1 CLIP3 TNC EGFLAM	2.45e-05	189	81	5	a5306561026e4dfcc39beeb785e5108ac595d136
ToppCell	facs-Kidney-nan-3m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO3 SNED1 CLIP3 TNC EGFLAM	2.45e-05	189	81	5	381058f55908f84375b54601d617389ef43ab855
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.45e-05	189	81	5	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	P03-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEMA5B SCUBE3 SEMA5A ADAM33 ZFHX3	2.45e-05	189	81	5	b5439ef221106f6d54434f268485e9bb17b39102
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO3 SNED1 CLIP3 TNC EGFLAM	2.45e-05	189	81	5	302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.52e-05	190	81	5	d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS LPXN ITGB7 ZAP70 PYHIN1	2.52e-05	190	81	5	af39d2a46d9502cec69a69b7e8ffef78fc8311c3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.52e-05	190	81	5	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 ACAN LRP8	2.52e-05	190	81	5	39ab890104b4264c68a968f920f4ccd84f0bc681
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B SEMA5A MATN4 RNF128 MEGF11	2.52e-05	190	81	5	9b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B SEMA5A MATN4 RNF128 MEGF11	2.52e-05	190	81	5	d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	KCNC2 ZFHX2 SEMA5A MATN4 LTBP3	2.58e-05	191	81	5	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 SEMA5A GMPR THSD7B	2.58e-05	191	81	5	06760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ADAMTS6 SEMA5A ADAM33 GMPR	2.65e-05	192	81	5	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TES SEMA5B ACAN ZFHX3 EGFLAM	2.65e-05	192	81	5	71863f18a82394ed9f8e5ec8a4017215382a8284
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ERBB4 SEMA5B ACAN SEMA5A ZFHX3	2.65e-05	192	81	5	a7d08416f07f29ad920168a3b52ddf992f263bf4
ToppCell	ASK452-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	TES ITGB7 ZAP70 PYHIN1 FAM98C	2.65e-05	192	81	5	f04ee5aaa54c39b7493098fb3d2f78168d6b8060
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 KCNC2 ADAMTS6 ADAM33 THSD7B	2.65e-05	192	81	5	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.71e-05	193	81	5	4979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA5B ACAN SCUBE3 ADAM33 ZFHX3	2.71e-05	193	81	5	469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS LPXN ITGB7 ZAP70 PYHIN1	2.71e-05	193	81	5	d8e6a7f1da4506acaa06380b4aec3fe299ec8b7e
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RSPO3 SEMA5B TNC SEMA5A EGFLAM	2.71e-05	193	81	5	c5bd0ed6f57459e54d2463318e8d9b1879718e63
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.71e-05	193	81	5	53bcd50892c379b2a571751f6eb1062436339fe7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.71e-05	193	81	5	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGF EYS ERBB4 KCNC2 LRP8	2.78e-05	194	81	5	e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS LPXN ITGB7 ZAP70 PYHIN1	2.78e-05	194	81	5	da88e8c11e55df296d2533f1d1575779cdf3edd7
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RSPO3 SEMA5B TNC SEMA5A EGFLAM	2.78e-05	194	81	5	c45e9d09b5cd6973de6c3f1713b3bf36fa4bfe57
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS LPXN ITGB7 ZAP70 PYHIN1	2.85e-05	195	81	5	441345d33f839a9e9222e790752b5603ff572bf2
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA5B ACAN SCUBE3 ADAM33 ZFHX3	2.85e-05	195	81	5	43d372373367b71243c6ea958aedccde4478618f
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERBB4 ACAN SEMA5A RNF128 MEGF11	2.92e-05	196	81	5	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERBB4 ACAN SEMA5A RNF128 MEGF11	2.92e-05	196	81	5	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	LPS_only-Hematopoietic_Lymphocytic\|LPS_only / Treatment groups by lineage, cell group, cell type	LPXN AIP ITGB7 ZAP70 PYHIN1	3.07e-05	198	81	5	e4e362dca57adba90a2be38dce810857baa2f265
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	RSPO3 HGF TNC SEMA5A EGFLAM	3.07e-05	198	81	5	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-Lymphocytic_NK/T\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ADSL TACC3 ITGB7 ZAP70 PYHIN1	3.07e-05	198	81	5	22c412a8d370fabfe4ccfad0b4c24fc965b88b74
Drug	2-methylcarbazole	GMPR GMPR2	1.22e-05	2	80	2	CID000019290
Drug	m-nitrobenzamidine hydrochloride	GMPR GMPR2	1.22e-05	2	80	2	CID000165122
Drug	3-nitrofluoranthen-6-ol	GMPR GMPR2	1.22e-05	2	80	2	CID000146572
Drug	3-nitrofluoranthen-9-ol	GMPR GMPR2	1.22e-05	2	80	2	CID000146573
Drug	3-nitrofluoranthen-8-ol	GMPR GMPR2	1.22e-05	2	80	2	CID000146567
Drug	1,3,6-trinitropyrene	GMPR GMPR2	1.22e-05	2	80	2	CID000053229
Drug	2-nitrobenzofuran	GMPR GMPR2	1.22e-05	2	80	2	CID000036328
Drug	1,3,6,8-tetranitropyrene	GMPR GMPR2	1.22e-05	2	80	2	CID000034321
Drug	AC1L25J4	GMPR GMPR2	1.22e-05	2	80	2	CID000041328
Drug	thiopurinol	ADSL GMPR GMPR2	1.48e-05	14	80	3	CID000667510
Drug	1,3-dinitropyrene	GMPR GMPR2 PHIP	1.84e-05	15	80	3	CID000053230
Drug	2-py	ERBB4 MAZ ZAP70	1.84e-05	15	80	3	CID010126464
Drug	1,6-dinitropyrene	GMPR GMPR2 PHIP	4.56e-05	20	80	3	CID000039184
Drug	Ergocryptine-alpha [511-09-1]; Up 200; 7uM; PC3; HT_HG-U133A	HGF SEMA5A PLA2G6 GMPR MUC2 SLC4A5	6.31e-05	194	80	6	4552_UP
Drug	Tobramycin [32986-56-4]; Up 200; 8.6uM; PC3; HT_HG-U133A	LIG3 CLCN4 ACAN PLA2G6 IMPG2 PYHIN1	7.26e-05	199	80	6	4081_UP
Drug	anilino acetate	GMPR GMPR2	7.28e-05	4	80	2	CID000153367
Drug	c0458	GMPR GMPR2	7.28e-05	4	80	2	CID009543178
Drug	nitromethanamine	GMPR GMPR2	7.28e-05	4	80	2	CID000061148
Drug	1-amino-8-nitropyrene	GMPR GMPR2	7.28e-05	4	80	2	CID000108113
Drug	methyl p-nitrobenzoate	GMPR GMPR2	7.28e-05	4	80	2	CID000012083
Drug	chondroitin sulfate	RSPO3 HGF ADSL SEMA5B TNC ACAN SEMA5A IMPG2	1.02e-04	413	80	8	CID000024766
Drug	AC1LARMV	HGF GMPR GMPR2	1.02e-04	26	80	3	CID000493817
Drug	16alpha-hydroxyestrone	CNBP INSRR HSD17B2	1.15e-04	27	80	3	CID000114852
Drug	nitroquinoline	GMPR GMPR2	1.21e-04	5	80	2	CID000025551
Drug	musk tibetene	GMPR GMPR2	1.21e-04	5	80	2	CID000067350
Drug	2-hydroxylamino-4-nitrotoluene	GMPR GMPR2	1.21e-04	5	80	2	CID005488156
Drug	4-nitrohippuric acid	GMPR GMPR2	1.21e-04	5	80	2	CID000017549
Drug	dimetridazole	GMPR GMPR2	1.21e-04	5	80	2	CID000003090
Disease	mucinous adenocarcinoma (is_marker_for)	ZFHX3 MUC2	7.04e-05	5	79	2	DOID:3030 (is_marker_for)
Disease	severe acute respiratory syndrome, COVID-19	ZCCHC4 EYS SCUBE1 SEMA5B ZFHX3 LTBP3 MEGF11	1.98e-04	447	79	7	EFO_0000694, MONDO_0100096
Disease	health-related quality of life measurement	SEMA5A PARP12	2.52e-04	9	79	2	EFO_0011014
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP9	3.14e-04	10	79	2	DOID:1969 (implicated_via_orthology)
Disease	blood copper measurement	ERBB4 IZUMO3 PM20D2	3.31e-04	50	79	3	EFO_0007578
Disease	stenosing tenosynovitis	ADAMTS6 LTBP3	4.59e-04	12	79	2	EFO_0010822
Disease	cholangiocarcinoma (biomarker_via_orthology)	HGF TNC	5.42e-04	13	79	2	DOID:4947 (biomarker_via_orthology)
Disease	homostachydrine measurement	EYS ERBB4	5.42e-04	13	79	2	EFO_0021164
Disease	hypoxanthine mesurement	ERBB4 GMPR	6.31e-04	14	79	2	EFO_0010500
Disease	sexual dimorphism measurement	RSPO3 ACAN SCUBE3 TMPRSS12 ZFHX3 ASXL2 LTBP3 AIP TACC3 PHIP	7.26e-04	1106	79	10	EFO_0021796
Disease	response to peritoneal dialysis, peritoneal solute transfer rate	KCNC2 KDM2B	7.27e-04	15	79	2	EFO_0600089, EFO_0600090
Disease	cortical surface area measurement	JAG2 RSPO3 HGF SCUBE1 TES ZAN SEMA5A ZFHX3 TACC3 LRP8 AGAP3	8.89e-04	1345	79	11	EFO_0010736
Disease	unipolar depression, response to bupropion, mood disorder	ADAMTS6 TNC	1.18e-03	19	79	2	EFO_0003761, EFO_0004247, EFO_0006326
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	SEMA5B ZFHX3	1.30e-03	20	79	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	Osteoarthritis of hip	TNC LTBP3	1.30e-03	20	79	2	C0029410
Disease	Nonsyndromic Deafness	HGF TNC OTOG	1.36e-03	81	79	3	C3711374
Disease	longitudinal BMI measurement	ERBB4 ADAMTS6 IZUMO3	1.40e-03	82	79	3	EFO_0005937
Disease	Giant Cell Glioblastoma	JAG2 TES TACC3	1.51e-03	84	79	3	C0334588
Disease	FEV/FEC ratio	RSPO3 FCGBP CLCN4 ACAN BHLHA9 SCUBE3 ADAM33 ZFHX3 LTBP3 AGAP3	1.60e-03	1228	79	10	EFO_0004713
Disease	body composition measurement	JAG2 RSPO3 ADSL ACAN	1.82e-03	193	79	4	EFO_0005106
Disease	stomach carcinoma (is_marker_for)	ERBB4 SPINT1	1.88e-03	24	79	2	DOID:5517 (is_marker_for)
Disease	body weight	EYS ERBB4 NTNG2 ADSL ACAN PLA2G6 ZFHX3 LTBP3 THSD7B IZUMO3	1.94e-03	1261	79	10	EFO_0004338
Disease	osteoarthritis, hip	TNC LTBP3 TACC3	1.95e-03	92	79	3	EFO_1000786
Disease	colorectal health	EYS KCNC2 SEMA5A ZFHX3	2.11e-03	201	79	4	EFO_0008460

Protein segments in the cluster

Peptide	Gene	Start	Entry
DILIQHGCPGEGCGL	AGAP3	836	Q96P47
HRECAGGCSGPKDTD	ERBB4	231	Q15303
EREGTGHGGPKLCCT	CFAP410	146	O43822
FTCGCPHDLVLGVDG	EGFL8	166	Q99944
PLGFEGLHCQKECGN	EGFLAM	811	Q63HQ2
EGDGCTALHLACRKG	AGAP9	666	Q5VTM2
CGHLECHGPAARGDT	BHLHA9	131	Q7RTU4
GHFLPCAGRDALCGK	ADAM33	561	Q9BZ11
LGKEGPLVHVACCCG	CLCN4	221	P51793
KGCGAFCHDDCIGPS	ASXL2	1411	Q76L83
GECKHVGCDNILGSD	ADAMTS6	686	Q9UKP5
GKDPLEGQRHCCGVA	AIP	111	O00170
ACPDKGIVLCGDEEG	LRWD1	561	Q9UFC0
RCEELCAPGTHGKGC	MEGF11	171	A6BM72
GKLHCPADVCGPLFE	KCNC2	121	Q96PR1
SRLCGKDQCAEGGHG	MATN4	211	O95460
CGVTFHGICQDKGPA	EYS	461	Q5T1H1
PCHSGGLCEDLADGF	JAG2	506	Q9Y219
DGCGCPDHTFLDEKG	MUC2	696	Q02817
GPHHVCELCNKGTGE	MAZ	416	P56270
DLGIATVPKGHCASC	LPXN	141	O60711
GLKGHIISDGGCSCP	GMPR2	211	Q9P2T1
EICAGAEKIGSGPCE	HGF	656	P14210
SVLGECLDHFGPGCV	MTPAP	286	Q9NVV4
GLHVGLCSGPCEMAE	LIG3	76	P49916
EPCGAGTCKETEGHV	ACAN	2286	P16112
ISPEGGLCSGHGRCK	ITGB7	606	P26010
RAHQGSKPGCVGLCA	PARP12	76	Q9H0J9
LPHTAVCLVCGEAGK	KDM2B	656	Q8NHM5
LELAVLGACLCHGPG	CCDC125	271	Q86Z20
GGILSCVTKDPCHGV	FCGBP	4036	Q9Y6R7
VGKGECHNIPCEKGD	PYHIN1	356	Q6K0P9
LNECAKPHLCGDGGF	LTBP3	661	Q9NS15
KLGEECADVCPGVLG	INSRR	171	P14616
HCPDRALCGGDGAAA	FAM98C	91	Q17RN3
GLKGHIISDGGCTCP	GMPR	211	P36959
CKAGAHGVGDPAAAV	CLIP3	126	Q96DZ5
HGCLLDLGTCQAEPG	C9orf57	91	Q5W0N0
LVTGGDCGLGHALCK	HSD17B2	86	P37059
HGCAHICRETPKGGV	SCUBE1	171	Q8IWY4
HGCAHICRETPKGGI	SCUBE3	166	Q8IX30
ACGEGAADIIIGHLC	AFP	471	P02771
GGADEAGCATLCAPH	LRP8	156	Q14114
PLSAFHGVKGCLECD	IZUMO3	11	Q5VZ72
SKAQGHGLCGICDGD	OTOG	2241	Q6ZRI0
HGLCGICDGDAANDL	OTOG	2246	Q6ZRI0
EGAAGPKCDDCLPTH	NTNG2	431	Q96CW9
ADLGKGKLHLAGPCC	RTBDN	46	Q9BSG5
GAEEECRHGGVCAPA	TACC3	231	Q9Y6A5
GLGHEQGFGAPCLKC	TES	11	Q9UGI8
CGQHCGKPEDCGELG	SSPOP	841	A2VEC9
GKPEDCGELGSCVAG	SSPOP	846	A2VEC9
EGCFCPEGTLLHGGA	SSPOP	1311	A2VEC9
DGGHCEELVPACAEG	SSPOP	1366	A2VEC9
GHCCPKAAGIIHLGA	ADSL	96	P30566
GDKEIGPDGDSCAVC	RNF128	266	Q8TEB7
AHGFPCCGKGSVEVA	SPATA32	6	Q96LK8
EGCTPLHLACRKGDG	PLA2G6	151	O60733
CLNDGKCDIMPGHGA	IMPG2	1061	Q9BZV3
CHCGLGGRGQPKDAT	PLA2G2D	46	Q9UNK4
LCEYDALPGIGHACG	PM20D2	111	Q8IYS1
ADAHSCDCGPGFKGR	SNED1	1326	Q8TER0
GGDICLGLHTEEALC	SEMA5A	876	Q13591
EGDGCTALHLACRKG	AGAP5	621	A6NIR3
NCGRGGHIAKDCKEP	CNBP	76	P62633
GGACAGLKEDLGACL	COA5	11	Q86WW8
IAGGKAHCGPAELCE	ZAP70	71	P43403
HGDGPRICKLCGNAF	ZNF441	191	Q8N8Z8
PEALGGGDKLACGAC	ZFHX2	1471	Q9C0A1
GQGHGAVFDCKCSPD	PHIP	511	Q8WWQ0
GCVEASLCLAHFGGP	UFSP1	16	Q6NVU6
SDKGHCVDLPDTGLC	SPINT1	386	O43278
ADCGELKCPNGCSGH	TNC	401	P24821
EGGAHAEDCGTAPLK	TMPRSS12	56	Q86WS5
HLGKCLDNCPEGLEA	RSPO3	121	Q9BXY4
CGIDACFGLETPKLH	SLC4A5	791	Q9BY07
CGGLDCLGPAIHIAN	SEMA5B	646	Q9P283
CKGDSGGPLSCHIDG	PRSS48	216	Q7RTY5
HSCEGPKHGCFICGE	ZCCHC4	436	Q9H5U6
VHTGESPHVCGDCGK	ZNF792	331	Q3KQV3
GERPHGCGECGKAFS	ZNF792	446	Q3KQV3
LASEGICFPDHGKCG	THSD7B	546	Q9C0I4
ICFPDHGKCGLGHRI	THSD7B	551	Q9C0I4
QHAGSLCELGVGECP	ZFHX3	621	Q15911
QCGCKDAHGGSIPLG	ZAN	2266	Q9Y493
IHSGERPHECGECGK	ZNF776	481	Q68DI1
AGCLLKCSGHGHCDP	KIAA0319	911	Q5VV43