Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	EPS8L2 PLEKHG4 GBP3 DIS3 TIAM2 ARHGEF33 LLGL1 PLEKHG3 ITSN2 TBCK PLCB1 DNMBP PREX1 ARHGAP33 ACAP3	4.81e-05	507	177	15	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	EPS8L2 PLEKHG4 GBP3 DIS3 TIAM2 ARHGEF33 LLGL1 PLEKHG3 ITSN2 TBCK PLCB1 DNMBP PREX1 ARHGAP33 ACAP3	4.81e-05	507	177	15	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	EPS8L2 PLEKHG4 DIS3 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	2.26e-04	231	177	9	GO:0005085
Domain	RhoGEF	PLEKHG4 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	3.63e-06	68	177	7	SM00325
Domain	RhoGEF	PLEKHG4 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	4.42e-06	70	177	7	PF00621
Domain	DH_2	PLEKHG4 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	4.42e-06	70	177	7	PS50010
Domain	-	PLEKHG4 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	4.86e-06	71	177	7	1.20.900.10
Domain	DH-domain	PLEKHG4 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	4.86e-06	71	177	7	IPR000219
Domain	NACHT	NLRX1 TEP1 NLRC5 NLRC3	6.00e-05	23	177	4	PS50837
Domain	NACHT_NTPase	NLRX1 TEP1 NLRC5 NLRC3	6.00e-05	23	177	4	IPR007111
Domain	CK1gamma_C	CSNK1G3 CSNK1G1	2.66e-04	3	177	2	PF12605
Domain	Runt	RUNX2 RUNX1	2.66e-04	3	177	2	PF00853
Domain	RUNT	RUNX2 RUNX1	2.66e-04	3	177	2	PS51062
Domain	TF_Runt-rel_RUNX	RUNX2 RUNX1	2.66e-04	3	177	2	IPR016554
Domain	RunxI	RUNX2 RUNX1	2.66e-04	3	177	2	PF08504
Domain	Casein_kinase-1_gamma_C	CSNK1G3 CSNK1G1	2.66e-04	3	177	2	IPR022247
Domain	Runt_dom	RUNX2 RUNX1	2.66e-04	3	177	2	IPR013524
Domain	RunxI_C_dom	RUNX2 RUNX1	2.66e-04	3	177	2	IPR013711
Domain	Runx_central_dom	RUNX2 RUNX1	2.66e-04	3	177	2	IPR027384
Domain	-	RUNX2 RUNX1	2.66e-04	3	177	2	4.10.770.10
Domain	AML1_Runt	RUNX2 RUNX1	2.66e-04	3	177	2	IPR000040
Domain	DH_1	PLEKHG4 TIAM2 PLEKHG3 DNMBP PREX1	3.26e-04	63	177	5	PS00741
Domain	USP_CS	USP17L7 USP17L2 USP38 USP32 USP7	4.05e-04	66	177	5	IPR018200
Domain	GDS_CDC24_CS	PLEKHG4 TIAM2 DNMBP PREX1	4.95e-04	39	177	4	IPR001331
Domain	USP_1	USP17L7 USP17L2 USP38 USP32 USP7	5.31e-04	70	177	5	PS00972
Domain	HEAT_REPEAT	SMG1 COPG1 EIF4G3 BRAT1 AP3D1	5.31e-04	70	177	5	PS50077
Domain	UCH	USP17L7 USP17L2 USP38 USP32 USP7	5.67e-04	71	177	5	PF00443
Domain	USP_2	USP17L7 USP17L2 USP38 USP32 USP7	5.67e-04	71	177	5	PS00973
Domain	USP_3	USP17L7 USP17L2 USP38 USP32 USP7	6.05e-04	72	177	5	PS50235
Domain	USP_dom	USP17L7 USP17L2 USP38 USP32 USP7	6.05e-04	72	177	5	IPR028889
Domain	Peptidase_C19_UCH	USP17L7 USP17L2 USP38 USP32 USP7	6.05e-04	72	177	5	IPR001394
Domain	BRO1	PTPN23 BROX	8.76e-04	5	177	2	PF03097
Domain	BRO1_dom	PTPN23 BROX	8.76e-04	5	177	2	IPR004328
Domain	BRO1	PTPN23 BROX	8.76e-04	5	177	2	SM01041
Domain	BRO1	PTPN23 BROX	8.76e-04	5	177	2	PS51180
Domain	-	PTPN23 BROX	8.76e-04	5	177	2	1.25.40.280
Domain	p53/RUNT-type_TF_DNA-bd	RUNX2 RUNX1	1.31e-03	6	177	2	IPR012346
Domain	-	RUNX2 RUNX1	1.31e-03	6	177	2	2.60.40.720
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCL SEMA4B MYO7A NLRX1 TWNK PAPLN TEP1 TIAM2 HIRA ITPR2 PCNX2 PRR12 PIM3 TNRC18 IGF2R USP7 NLRC5 BAMBI LRRC14 GPC2 DNMBP ESPL1 BRAT1 PREX1 AP3D1 ARHGAP33	1.29e-10	1105	180	26	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SMG1 IFT140 WAPL DIS3 TIAM2 CAPN10 USP38 NRXN2 ANAPC2 PLCB1 RPRD2 DNMBP ESPL1 KCNT1 ACAP3	1.26e-07	529	180	15	14621295
Pubmed	Molecular mapping within the mouse albino-deletion complex.	MYO7A OCA2 TYR	1.36e-07	3	180	3	2813427
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 KNTC1 SEMA4B PTPN23 PRR12 VPS13D TNRC18 PLEKHG3 LTN1 TXNDC16 ATP11A LRRC14 PREX1 SNRNP200	3.31e-07	493	180	14	15368895
Pubmed	A major gene controlling warfarin-resistance in the house mouse.	MYO7A OCA2 TYR	5.43e-07	4	180	3	1063212
Pubmed	Genetics of warfarin-resistance in house mice of three separate localities.	MYO7A OCA2 TYR	5.43e-07	4	180	3	621381
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 SP1 CTDSPL2 NUMA1 ITGB3 TASOR2 TNRC18 NFE2L1 CCDC87 USP7 ARRDC3 EIF4G3	2.81e-06	430	180	12	35044719
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 SMG1 PTPN23 DIS3 NRXN2 PLCB1 RPRD2 PREX1 SNRNP200	2.90e-06	225	180	9	12168954
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SEMA4B LRP12 PLEKHG4 NLRX1 TTC27 PCDHA12 GALNT12 EXT1 DIS3 MTFR1L RETREG3 BROX IGF2R TMTC4 LTN1 BAMBI LRRN2 DCBLD2 HSPA6	2.90e-06	1061	180	19	33845483
Pubmed	An Analysis of Translocations in the Mouse.	MYO7A OCA2 TYR	4.70e-06	7	180	3	17247190
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KNTC1 SMG1 DCAF13 CTDSPL2 NUMA1 CCNO TWNK DHX57 EPX ESF1 TASOR2 RPS6KC1 TNRC18 ITSN2 ATP11A EIF4G3 DNAH8 PREX1 HSPA6 AP3D1 PLXNA2 CFAP46	6.09e-06	1442	180	22	35575683
Pubmed	Dominance of SOX9 function over RUNX2 during skeletogenesis.	COL9A1 RUNX2 RUNX1	7.49e-06	8	180	3	17142326
Pubmed	Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.	RUNX2 RUNX1 SMAD3	7.49e-06	8	180	3	10531362
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF13 WAPL GALK1 COPG1 PLEKHG4 NUMA1 TTC27 PTPN23 DHX57 RUNX1 DIS3 ESF1 HIRA LLGL1 PLEKHG3 LTN1 USP7 SNRNP200 HSPA6 AP3D1	2.60e-05	1353	180	20	29467282
Pubmed	HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.	NLRX1 STING1	2.66e-05	2	180	2	31874109
Pubmed	The cDNA cloning of the transcripts of human PEBP2alphaA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia.	RUNX2 RUNX1	2.66e-05	2	180	2	9233771
Pubmed	Molecular basis of oculocutaneous albinism.	OCA2 TYR	2.66e-05	2	180	2	7963676
Pubmed	The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase.	OCA2 TYR	2.66e-05	2	180	2	12028586
Pubmed	Influence of gene duplication and X-inactivation on mouse mitochondrial malic enzyme activity and electrophoretic patterns.	MYO7A TYR	2.66e-05	2	180	2	863237
Pubmed	Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination.	RUNX2 SMAD3	2.66e-05	2	180	2	16227596
Pubmed	NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy.	NLRX1 STING1	2.66e-05	2	180	2	39357547
Pubmed	Oculocutaneous albinism (OCA) in Colombia: first molecular screening of the TYR and OCA2 genes in South America.	OCA2 TYR	2.66e-05	2	180	2	25455140
Pubmed	The Linkage of Dark-Eye and Color in Mice.	OCA2 TYR	2.66e-05	2	180	2	17246260
Pubmed	Molecular analysis of radiation-induced albino (c)-locus mutations that cause death at preimplantation stages of development.	MYO7A TYR	2.66e-05	2	180	2	8307326
Pubmed	Ins(1,4,5)P(3) regulates phospholipase Cbeta1 expression in cardiomyocytes.	ITPR2 PLCB1	2.66e-05	2	180	2	18692062
Pubmed	CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity.	SP1 SMAD3	2.66e-05	2	180	2	16021625
Pubmed	Variations of Linkage in Rats and Mice.	OCA2 TYR	2.66e-05	2	180	2	17246029
Pubmed	Linkage of a Dilute Color Factor and Dark-Eye in Mice.	OCA2 TYR	2.66e-05	2	180	2	17246039
Pubmed	Linkage of Albino Allelomorphs in Rats and Mice.	OCA2 TYR	2.66e-05	2	180	2	17246054
Pubmed	Genetic basis of susceptibility to splenic lipofuscinosis in mice.	OCA2 TYR	2.66e-05	2	180	2	7117836
Pubmed	A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.	WAPL HASPIN	2.66e-05	2	180	2	29138236
Pubmed	Genetic Causes of Oculocutaneous Albinism in Pakistani Population.	OCA2 TYR	2.66e-05	2	180	2	33800529
Pubmed	The cell cycle of early mammalian embryos: lessons from genetic mouse models.	UBA3 ANAPC2	2.66e-05	2	180	2	16481745
Pubmed	CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.	SEMA4B DCBLD2	2.66e-05	2	180	2	17213806
Pubmed	Runx2/Smad3 complex negatively regulates TGF-β-induced connective tissue growth factor gene expression in vascular smooth muscle cells.	RUNX2 SMAD3	2.66e-05	2	180	2	21986102
Pubmed	IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis.	STING1 IGF2R	2.66e-05	2	180	2	37863414
Pubmed	Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence.	MYO7A TYR	2.66e-05	2	180	2	19324852
Pubmed	A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2).	OCA2 TYR	2.66e-05	2	180	2	12727022
Pubmed	Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.	RUNX2 RUNX1	2.66e-05	2	180	2	16059634
Pubmed	A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer.	CCNP CCNO	2.66e-05	2	180	2	28860486
Pubmed	PlexinA2 mediates osteoblast differentiation via regulation of Runx2.	RUNX2 PLXNA2	2.66e-05	2	180	2	22095611
Pubmed	RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells.	RUNX2 RUNX1	2.66e-05	2	180	2	32180230
Pubmed	The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.	HSPA6 HSPA7	2.66e-05	2	180	2	1346391
Pubmed	Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.	SP1 TIAM2	2.66e-05	2	180	2	26763486
Pubmed	Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.	RUNX2 RUNX1	2.66e-05	2	180	2	17290219
Pubmed	Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: Increased carriage of TYR and OCA2 variants.	OCA2 TYR	2.66e-05	2	180	2	32966289
Pubmed	USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.	FBXO7 USP7	2.66e-05	2	180	2	37874827
Pubmed	Prenatal molecular diagnosis of oculocutaneous albinism (OCA) in a large cohort of Israeli families.	OCA2 TYR	2.66e-05	2	180	2	19626598
Pubmed	Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells.	RUNX2 RUNX1	2.66e-05	2	180	2	35551452
Pubmed	Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.	RUNX2 RUNX1	2.66e-05	2	180	2	23321257
Pubmed	Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation.	ABCC1 ATF4	2.66e-05	2	180	2	33782384
Pubmed	Linkage in Mice and Rats.	OCA2 TYR	2.66e-05	2	180	2	17245945
Pubmed	Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide.	OCA2 TYR	2.66e-05	2	180	2	11254699
Pubmed	Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma.	LAMP2 SMAD3	2.66e-05	2	180	2	35267139
Pubmed	Tail short variable: characterization of a new mouse mutant, and its possible analogy to certain human vascular disruption defects.	OCA2 TYR	2.66e-05	2	180	2	8278937
Pubmed	Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats).	SP1 RUNX2	2.66e-05	2	180	2	19017640
Pubmed	Mutational Analysis of the TYR and OCA2 Genes in Four Chinese Families with Oculocutaneous Albinism.	OCA2 TYR	2.66e-05	2	180	2	25919014
Pubmed	Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells.	RUNX2 RUNX1	2.66e-05	2	180	2	17533052
Pubmed	Pink-eyed dilution protein controls the processing of tyrosinase.	OCA2 TYR	2.66e-05	2	180	2	12058062
Pubmed	PRMT5 regulates ATF4 transcript splicing and oxidative stress response.	PRMT5 ATF4	2.66e-05	2	180	2	35305370
Pubmed	Studies on the mouse hemoglobin loci. II. Position of the hemoglobin locus with respect to albinism and shaker-1 loci.	MYO7A OCA2	2.66e-05	2	180	2	14487977
Pubmed	A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice.	RUNX2 RUNX1	2.66e-05	2	180	2	27634876
Pubmed	Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons.	LBX1 KCNT1	2.66e-05	2	180	2	35626730
Pubmed	Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon.	STING1 NLRC3	2.66e-05	2	180	2	30893587
Pubmed	Microdissection and microcloning from the proximal region of mouse chromosome 7: isolation of clones genetically linked to the pudgy locus.	OCA2 TYR	2.66e-05	2	180	2	3319884
Pubmed	Novel and recurrent mutations in the tyrosinase gene and the P gene in the German albino population.	OCA2 TYR	2.66e-05	2	180	2	10987646
Pubmed	Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3.	NLRX1 NLRC3	2.66e-05	2	180	2	22718770
Pubmed	Inheritance of the macrophage alloantigenic marker (Mph-1) in inbred mice.	OCA2 TYR	2.66e-05	2	180	2	1225761
Pubmed	Identification and expression of a novel 3'-exon of mouse Runx1/Pebp2alphaB/Cbfa2/AML1 gene.	RUNX2 RUNX1	2.66e-05	2	180	2	10903914
Pubmed	The core binding factor CBF negatively regulates skeletal muscle terminal differentiation.	RUNX2 RUNX1 PRMT5	2.90e-05	12	180	3	20195544
Pubmed	RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.	RUNX1 BAMBI ATF4 SMAD3	3.20e-05	35	180	4	32281291
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	USP17L7 ATG16L1 COPG1 MYO7A HSPBAP1 PIDD1 ITPR2 RPS6KC1 FRY RNF123 ARHGEF33 PRMT5 CCDC87 SNRNP200	3.24e-05	736	180	14	29676528
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	SEMA4B TMPRSS5 LRRN2 DCBLD2 PLXNA2 EPHA5	3.44e-05	117	180	6	17145500
Pubmed	Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.	F2 ITGB3 LIPC	3.75e-05	13	180	3	14557872
Pubmed	Platelet storage pool deficiency associated with inherited abnormalities of the inner ear in the mouse pigment mutants muted and mocha.	OSTM1 TYR AP3D1	4.76e-05	14	180	3	1912584
Pubmed	Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.	NLRX1 NLRC5 NLRC3	4.76e-05	14	180	3	26320999
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WAPL CNST STXBP4 PTPN23 DIS3 TIAM2 ESF1 RPS6KC1 IGF2R NFE2L1 CSNK1G3 LTN1 FBXO7 TMEM131 ATP11A ANKRD12 ESPL1	5.27e-05	1084	180	17	11544199
Pubmed	Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.	MYO7A TYR RABGGTA	5.93e-05	15	180	3	18715234
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	IFT140 VPS13D NRXN2 ITSN2 SNRNP200 PLXNA2	6.20e-05	130	180	6	12421765
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L7 USP17L2 USP38 USP32 USP7	6.55e-05	81	180	5	12838346
Pubmed	Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis.	CSNK1G1 KCNT1	7.96e-05	3	180	2	24463883
Pubmed	Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling.	BAMBI SMAD3	7.96e-05	3	180	2	15240101
Pubmed	Knockdown of NLRC5 inhibits renal fibroblast activation via modulating TGF-β1/Smad signaling pathway.	NLRC5 SMAD3	7.96e-05	3	180	2	29608899
Pubmed	Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors.	RUNX2 RUNX1	7.96e-05	3	180	2	19585539
Pubmed	Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development.	RUNX2 RUNX1	7.96e-05	3	180	2	14516670
Pubmed	Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.	SP1 USP7	7.96e-05	3	180	2	36759621
Pubmed	Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells.	SP1 PREX1	7.96e-05	3	180	2	21636851
Pubmed	Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection.	RUNX2 RUNX1	7.96e-05	3	180	2	12218099
Pubmed	NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.	NLRX1 STING1	7.96e-05	3	180	2	27078069
Pubmed	Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.	SP1 RUNX2	7.96e-05	3	180	2	19306294
Pubmed	Deletion mapping of four loci defined by N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7.	MYO7A TYR	7.96e-05	3	180	2	8307327
Pubmed	The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure.	NFE2L1 USP7	7.96e-05	3	180	2	33933455
Pubmed	Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling.	ITGB3 SMAD3	7.96e-05	3	180	2	26384307
Pubmed	SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-β signaling promotes prostate cancer bone metastasis.	SP1 SMAD3	7.96e-05	3	180	2	31925912
Pubmed	RUNX1 (RUNX family transcription factor 1), a target of microRNA miR-128-3p, promotes temozolomide resistance in glioblastoma multiform by upregulating multidrug resistance-associated protein 1 (MRP1).	ABCC1 RUNX1	7.96e-05	3	180	2	34895074
Pubmed	Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse.	OCA2 TYR	7.96e-05	3	180	2	5565073
Pubmed	Accumulation of murine amyloid-β mimics early Alzheimer's disease.	ABCC1 MMEL1	7.96e-05	3	180	2	25991605
Pubmed	Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese.	RUNX2 SMAD3	7.96e-05	3	180	2	25757091
Pubmed	Molecular analysis of Korean patients with oculocutaneous albinism.	OCA2 TYR	7.96e-05	3	180	2	22042571
Pubmed	HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia.	ITGB3 CD40LG	7.96e-05	3	180	2	21143381
Interaction	TOP3B interactions	MYCL SEMA4B TDRKH MYO7A NLRX1 TWNK DHX57 PAPLN TEP1 KANK2 TIAM2 HIRA ITPR2 PCNX2 PRR12 PIM3 TNRC18 IGF2R PRMT5 USP7 NLRC5 BAMBI LRRC14 GPC2 DNMBP ESPL1 BRAT1 PREX1 AP3D1 ARHGAP33	7.70e-06	1470	173	30	int:TOP3B
Interaction	SNX12 interactions	ATG16L1 PTPN23 LAMP2 STING1 TMTC4 USP7	8.35e-06	56	173	6	int:SNX12
Interaction	USP17L7 interactions	USP17L7 USP17L2 RNF123	1.22e-05	6	173	3	int:USP17L7
Interaction	GPIHBP1 interactions	GALNT12 PTPRU SELENON TXNDC16 TMEM131 DCBLD2 PLXNA2 RABGGTA	1.98e-05	133	173	8	int:GPIHBP1
Interaction	AP3S1 interactions	ATG16L1 DUSP6 LAMP2 STING1 ESF1 RNF123 CD14 AP3D1	3.01e-05	141	173	8	int:AP3S1
Interaction	CLEC12B interactions	LRP12 COPG1 GALNT12 EXT1 PTPRU TMEM131 GPC2 DCBLD2 PLXNA2	3.11e-05	184	173	9	int:CLEC12B
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 TIAM2 ARHGEF33 PLEKHG3 ITSN2 DNMBP PREX1	1.14e-07	66	106	7	722
GeneFamily	Ubiquitin specific peptidases	USP17L2 USP38 USP32 USP7	3.24e-04	56	106	4	366
GeneFamily	NLR family	NLRX1 NLRC5 NLRC3	4.10e-04	25	106	3	666
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL	ABCC1 SP1 SEMA4B IFT140 EPS8L2 OSTM1 NLRX1 MIF4GD GBP3 DPP3 PIM3 FRY MMEL1 NRXN2 ITSN2 PLCB1 MEDAG ATP11A DCBLD2 PLXNA2 RABGGTA SMAD3	5.48e-07	955	177	22	M45680
Coexpression	GSE11057_CD4_CENT_MEM_VS_PBMC_UP	ABCC1 CNST GALNT12 STING1 RUNX1 DALRD3 ESF1 PCNX2 ANKRD12 AMMECR1	1.04e-06	198	177	10	M3116
Coexpression	GSE27786_BCELL_VS_CD8_TCELL_DN	GABRR1 WAPL COPG1 GALNT12 MTFR1L IGF2R USP38 TMTC4 DNAH8 ACAP3	1.09e-06	199	177	10	M4802
Coexpression	GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP	LRP12 OSTM1 MYO7A NLRX1 RETREG3 PLEKHG3 NLRC3 AP3D1 SMAD3	4.14e-06	181	177	9	M6857
Coexpression	GSE11057_CD4_EFF_MEM_VS_PBMC_UP	ATG9B EPS8L2 CNST GALNT12 RUNX1 PCNX2 UNC5CL ANKRD12 AMMECR1	8.92e-06	199	177	9	M3113
Coexpression	GSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_6H_DN	SMG1 EPS8L2 WAPL CNST TTC27 CUZD1 NLRC5 DNMBP AP3D1	9.28e-06	200	177	9	M6404
Coexpression	GSE10147_IL3_VS_IL3_AND_HIVP17_STIM_PDC_UP	IFT140 CTDSPL2 ITPR2 CSNK1G1 USP32 RPRD2 ATP11A DNMBP	1.80e-05	166	177	8	M344
Coexpression	GSE27786_LSK_VS_CD4_TCELL_DN	SP1 STING1 RETREG3 VPS13D MTMR7 NLRC5 PREX1 NLRC3	6.77e-05	200	177	8	M4747
Coexpression	GSE42724_MEMORY_BCELL_VS_PLASMABLAST_DN	GALNT12 C1orf74 STING1 SELENON TMTC4 PLEKHG3 TXNDC16 EIF4G3	6.77e-05	200	177	8	M9791
Coexpression	GSE36392_EOSINOPHIL_VS_MAC_IL25_TREATED_LUNG_UP	ATG16L1 DUSP6 ITGB3 CD14 LBX1 SLC22A2 CUZD1 LRRN2	6.77e-05	200	177	8	M5280
ToppCell	IIF-Lymphocyte-T_NK-ILC\|IIF / Disease, Lineage and Cell Type	HSPBAP1 STING1 RUNX2 ITGB3 PIM3 SYCP2 TXNDC16	3.62e-06	159	178	7	55e4f21548f480ca414c00cbff5ec3b13bafd271
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	SP1 NUMA1 PTPN23 PCNX2 RNF123 RPRD2 MAP3K21	4.82e-06	166	178	7	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	droplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 LRP12 MYO7A RUNX1 MTMR7 RASEF PNPLA7	8.49e-06	181	178	7	8fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 LRP12 MYO7A RUNX1 MTMR7 RASEF PNPLA7	8.80e-06	182	178	7	be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell	(7)_DC_plasmacytoid\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	THEMIS2 MYCL ZAN PAPLN RUNX2 CFAP119 KCNK17	9.12e-06	183	178	7	2c6475c935b5a90931be6b3c53f1f707cfcd11f4
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 LRP12 MYO7A RUNX2 RUNX1 MTMR7 CUZD1	1.01e-05	186	178	7	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 LRP12 MYO7A RUNX2 RUNX1 MTMR7 CUZD1	1.01e-05	186	178	7	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	SMG1 SP1 WAPL VPS13D LTN1 TMEM131 ANKRD12	1.01e-05	186	178	7	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFT140 PTPN23 GBP3 FRY PLCB1 PREX1 SMAD3	1.05e-05	187	178	7	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFT140 PTPN23 GBP3 FRY PLCB1 PREX1 SMAD3	1.05e-05	187	178	7	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	MS-IIF-Lymphocyte-T/NK-ILC\|IIF / Disease, condition lineage and cell class	HSPBAP1 STING1 RUNX2 ITGB3 PIM3 SYCP2 TXNDC16	1.62e-05	200	178	7	edb0b252e6ff9824908d1ff7d0d42710b00949c8
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL PTPN23 C1orf74 RUNX2 TEP1 HASPIN	2.31e-05	142	178	6	0a87c0d74e281da5dc4f59e09a5e99c62b1ea801
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	DPF1 SP1 DUSP6 NUMA1 EXT1 PCNX2 VPS13D CCDC87 CUZD1 ATP11A LRRC14	3.86e-07	196	176	11	3837_UP
Drug	Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A	KPNA5 SP1 LRP12 HIRA ITPR2 CUZD1 PLCB1 PLXNA2 ARHGAP33 SMAD3	2.98e-06	195	176	10	4393_DN
Drug	Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; PC3; HT_HG-U133A	KPNA5 ABCC1 ATG16L1 NUMA1 RUNX1 DIS3 HIRA USP7 AP3D1 SMAD3	3.12e-06	196	176	10	6708_DN
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	NLRX1 DUSP6 PIDD1 ITPR2 VPS13D USP7 EIF4G3 SNRNP200 PLXNA2 ARHGAP33	3.27e-06	197	176	10	7521_UP
Drug	Ozagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; MCF7; HT_HG-U133A	KPNA5 IFT140 DUSP6 EXT1 RUNX1 DIS3 LBX1 CCDC87 CUZD1 ARHGAP33	3.74e-06	200	176	10	3503_UP
Drug	eptifibatide	F2 ITGB3 CD40LG	8.93e-06	6	176	3	ctd:C086648
Drug	Iocetamic acid [16034-77-8]; Down 200; 6.6uM; MCF7; HT_HG-U133A	KPNA5 DUSP6 PIDD1 RUNX1 DALRD3 HIRA VPS13D SYCP2 EIF4G3	2.01e-05	193	176	9	4425_DN
Drug	sodium 4-phenylbutyrate; Down 200; 1000uM; PC3; HG-U133A	MYCL DUSP6 CCNP NUMA1 CDKL3 TWNK RUNX1 AP3D1 SMAD3	2.19e-05	195	176	9	434_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; MCF7; HT_HG-U133A	MYCL CCNO PTPRU DALRD3 CAPN10 VPS13D RNF123 LRRC14 SMAD3	2.28e-05	196	176	9	3248_DN
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	SP1 IFT140 ATG16L1 MYO7A NLRX1 HIRA VPS13D PLCB1 LRRC14	2.28e-05	196	176	9	2210_DN
Drug	(d,l)-Tetrahydroberberine [522-97-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SP1 ATG16L1 LRP12 GALNT12 HIRA CAPN10 VPS13D PLCB1 LRRC14	2.28e-05	196	176	9	2818_DN
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A	IFT140 TDRKH GALK1 CCNO RUNX1 PCNX2 SYCP2 LRRC14 SMAD3	2.37e-05	197	176	9	3411_UP
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; HL60; HT_HG-U133A	KPNA5 MYCL DCAF13 GALK1 NUMA1 CAPN10 ANAPC2 ATP11A LRRC14	2.37e-05	197	176	9	2172_DN
Drug	Buspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; HL60; HT_HG-U133A	SP1 NLRX1 RUNX1 DIS3 VPS13D SYCP2 ATP11A ANKRD12 SMAD3	2.37e-05	197	176	9	1282_UP
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	SP1 NLRX1 CCNO ITPR2 RNF123 CUZD1 USP7 ARHGAP33 SMAD3	2.47e-05	198	176	9	5246_DN
Drug	Etodolac [41340-25-4]; Up 200; 14uM; MCF7; HT_HG-U133A	KPNA5 LRP12 CDKL3 RUNX1 TEP1 ITGB3 PCNX2 CUZD1 PLCB1	2.47e-05	198	176	9	7006_UP
Drug	colchicine; Down 200; 0.1uM; MCF7; HG-U133A	GALK1 CCNP DHX57 ITGB3 RLBP1 PCNX2 CSNK1G1 ITSN2 ARHGAP33	2.57e-05	199	176	9	644_DN
Drug	GBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	TDRKH DCAF13 NLRX1 EXT1 RUNX1 DIS3 ITPR2 PLCB1 AP3D1	2.67e-05	200	176	9	3240_DN
Disease	triacylglycerol 50:0 measurement	IGF2R PLCB1	3.30e-05	2	170	2	EFO_0021480
Disease	free cholesterol measurement	KANK2 LIPC IGF2R LLGL1 CSNK1G3 NYNRIN	5.08e-05	113	170	6	EFO_0008591
Disease	2-stearoyl-GPE (18:0) measurement	MYCL LIPC	9.86e-05	3	170	2	EFO_0800343
Disease	cholesteryl ester measurement, intermediate density lipoprotein measurement	KANK2 LIPC IGF2R LLGL1 CSNK1G3	2.17e-04	94	170	5	EFO_0008595, EFO_0010351
Disease	mean corpuscular hemoglobin concentration	KNTC1 ABCC1 SP1 IFT140 CTDSPL2 STXBP4 ALDH8A1 RUNX1 ITPR2 RP1L1 FBXO7 PLCB1 ATF4 ANKRD12 ARRDC3 EIF4G3 PREX1	2.32e-04	1105	170	17	EFO_0004528
Disease	oculocutaneous albinism (implicated_via_orthology)	OCA2 TYR	3.26e-04	5	170	2	DOID:0050632 (implicated_via_orthology)
Disease	N1-methyladenosine measurement	RUNX1 SLC22A2	4.88e-04	6	170	2	EFO_0021122
Disease	atherosclerosis (implicated_via_orthology)	F2 CD40LG	6.80e-04	7	170	2	DOID:1936 (implicated_via_orthology)
Disease	Albinism, Oculocutaneous	OCA2 TYR	6.80e-04	7	170	2	C0078918
Disease	Oculocutaneous albinism	OCA2 TYR	6.80e-04	7	170	2	cv:C0078918
Disease	cholesteryl esters to total lipids in large LDL percentage	LIPC SLC22A2 NLRC5	7.50e-04	31	170	3	EFO_0022249
Disease	obsolete_red blood cell distribution width	THEMIS2 MYCL ABCC1 SP1 GALK1 PAPLN RUNX1 KANK2 RLBP1 RNF123 NFE2L1 CSNK1G3 RP1L1 FBXO7 ATP11A LRRC14 ANKRD12 EIF4G3	8.06e-04	1347	170	18	EFO_0005192
Disease	esterified cholesterol measurement	LIPC IGF2R LLGL1 CSNK1G3 NYNRIN	8.95e-04	128	170	5	EFO_0008589
Disease	non-high density lipoprotein cholesterol measurement	SP1 GALK1 DPP3 EPX KANK2 LIPC IGF2R CSNK1G3 UNC5CL NYNRIN ITSN2 SMAD3	9.21e-04	713	170	12	EFO_0005689
Disease	Disproportionate short stature	IFT140 COL9A1 EXT1 RUNX2	1.04e-03	77	170	4	C0878659
Disease	free cholesterol in small HDL measurement	LIPC NYNRIN NLRC5	1.07e-03	35	170	3	EFO_0022270
Disease	Anti-Toxoplasma gondii IgG measurement	DCBLD2 HSPA6	1.16e-03	9	170	2	EFO_0009353
Disease	aplastic anemia (is_marker_for)	ANAPC2 CD40LG	1.16e-03	9	170	2	DOID:12449 (is_marker_for)
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	LIPC IGF2R LLGL1 CSNK1G3 NYNRIN	1.21e-03	137	170	5	EFO_0004611, EFO_0008591
Disease	platelet crit	THEMIS2 DPF1 STXBP4 RUNX1 EPX ITPR2 USP38 NFE2L1 CD40LG USP7 PLCB1 LRRN2 RPRD2 PREX1	1.28e-03	952	170	14	EFO_0007985
Disease	celiac disease (is_implicated_in)	F2 CD14	1.44e-03	10	170	2	DOID:10608 (is_implicated_in)
Disease	hair colour measurement, eye colour measurement, skin pigmentation measurement	OCA2 TYR	1.44e-03	10	170	2	EFO_0007009, EFO_0007822, EFO_0009764
Disease	thrombosis (implicated_via_orthology)	F2 CD40LG	1.44e-03	10	170	2	DOID:0060903 (implicated_via_orthology)
Disease	triglycerides to total lipids in large VLDL percentage	KANK2 LIPC NLRC5	1.47e-03	39	170	3	EFO_0022332
Disease	Disorder of eye	COL9A1 MYO7A OCA2 RLBP1 TYR SNRNP200	1.48e-03	212	170	6	C0015397
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	HIF3A LIPC IGF2R CSNK1G3 NYNRIN SLC22A2	1.59e-03	215	170	6	EFO_0008317, EFO_0008591
Disease	apolipoprotein B measurement	SP1 GALK1 KANK2 LIPC IGF2R LLGL1 CSNK1G3 NYNRIN SLC22A2 CSNK1G1 KCNK17	1.68e-03	663	170	11	EFO_0004615
Disease	retinitis pigmentosa (is_implicated_in)	IFT140 RLBP1 SNRNP200	1.71e-03	41	170	3	DOID:10584 (is_implicated_in)
Disease	1-stearoyl-GPE (18:0) measurement	MYCL LIPC	1.75e-03	11	170	2	EFO_0800227
Disease	pigmentation disease (is_implicated_in)	OCA2 TYR	1.75e-03	11	170	2	DOID:10123 (is_implicated_in)
Disease	triglycerides in large LDL measurement	LIPC IGF2R SLC22A2	1.96e-03	43	170	3	EFO_0022319
Disease	lymphocyte count	THEMIS2 MYCL ABCC1 ZAN HIF3A EPX F2 ITPR2 LIPC NRXN2 CD40LG USP7 PLCB1 NLRC5 PREX1 NLRC3 HSPA6 AP3D1	2.04e-03	1464	170	18	EFO_0004587
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	HIF3A LIPC IGF2R CSNK1G3 NYNRIN SLC22A2	2.18e-03	229	170	6	EFO_0004639, EFO_0008317
Disease	esophageal squamous cell carcinoma	STING1 RUNX1	2.47e-03	13	170	2	EFO_0005922
Disease	skin melanoma (is_implicated_in)	OCA2 TYR	2.87e-03	14	170	2	DOID:8923 (is_implicated_in)
Disease	sickle cell anemia (is_marker_for)	F2 CD40LG	2.87e-03	14	170	2	DOID:10923 (is_marker_for)
Disease	bacterial pneumonia (biomarker_via_orthology)	F2 ITGB3	2.87e-03	14	170	2	DOID:874 (biomarker_via_orthology)
Disease	Liver Cirrhosis	F2 CD14 BAMBI SMAD3	3.02e-03	103	170	4	C0023890
Disease	Retinitis Pigmentosa	IFT140 RLBP1 GARIN4 SNRNP200	3.13e-03	104	170	4	C0035334
Disease	Fibrosis, Liver	F2 CD14 BAMBI SMAD3	3.24e-03	105	170	4	C0239946
Disease	autoimmune thrombocytopenic purpura (is_implicated_in)	ITGB3 CD40LG	3.30e-03	15	170	2	DOID:8924 (is_implicated_in)
Disease	osteoarthritis (implicated_via_orthology)	COL9A1 SMAD3	3.30e-03	15	170	2	DOID:8398 (implicated_via_orthology)
Disease	cholesterol in small VLDL measurement	LIPC IGF2R SLC22A2	3.56e-03	53	170	3	EFO_0022228
Disease	remnant cholesterol measurement	LIPC IGF2R CSNK1G3 NYNRIN	3.58e-03	108	170	4	EFO_0010815
Disease	attempted suicide	DPF1 CNST RUNX1 DNAH8 PREX1	3.78e-03	178	170	5	EFO_0004321
Disease	very low density lipoprotein cholesterol measurement	HIF3A LIPC IGF2R CSNK1G3 NYNRIN SLC22A2	4.08e-03	260	170	6	EFO_0008317
Disease	allergic rhinitis (is_marker_for)	F2 CD40LG	4.24e-03	17	170	2	DOID:4481 (is_marker_for)
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	HSPA6 HSPA7	4.24e-03	17	170	2	EFO_0021969
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	LIPC IGF2R CSNK1G3 NYNRIN	4.34e-03	114	170	4	EFO_0004574, EFO_0004611
Disease	triglycerides in IDL measurement	LIPC IGF2R SLC22A2	4.60e-03	58	170	3	EFO_0022149
Disease	phospholipids in VLDL measurement	LIPC IGF2R SLC22A2	4.82e-03	59	170	3	EFO_0022301
Disease	basophil measurement	ABCC1 EXT1 RUNX1	5.05e-03	60	170	3	EFO_0803539
Disease	creatinine measurement	CCNP TTC27 FRY RNF123 LIPC IGF2R NRXN2 NFE2L1 SLC22A2 USP32 PNPLA7 NLRC3 SMAD3	5.18e-03	995	170	13	EFO_0004518
Disease	skin sensitivity to sun	OCA2 TYR	5.29e-03	19	170	2	EFO_0004795
Disease	glomerulonephritis (is_marker_for)	F2 ITGB3	5.29e-03	19	170	2	DOID:2921 (is_marker_for)
Disease	intrahepatic cholangiocarcinoma (is_marker_for)	RUNX1 TEP1	5.29e-03	19	170	2	DOID:4928 (is_marker_for)
Disease	free cholesterol in VLDL measurement	LIPC IGF2R SLC22A2	5.29e-03	61	170	3	EFO_0022276
Disease	cutaneous melanoma	OCA2 TASOR2 TYR ATP11A	5.36e-03	121	170	4	EFO_0000389

Protein segments in the cluster

Peptide	Gene	Start	Entry
DLLLCVARSPVFSSS	BRAT1	261	Q6PJG6
ANLDECIPATVRSSF	ALDH8A1	266	Q9H2A2
SADEPQCLLLLLDAF	ANAPC2	101	Q9UJX6
CSLNELEDAALTFPV	CTDSPL2	301	Q05D32
LDRFLTTTPVAADCF	CCNO	161	P22674
REASSQAPFIASLCL	CD40LG	181	P29965
LNPERTELLSCSRDD	ATG16L1	496	Q676U5
CLQIDPADRISSSDL	CDKL3	266	Q8IVW4
DLLTTLDDTCDLFAP	ATF4	111	P18848
CAERSLRLPFLDSQT	DPF1	31	Q92782
LCAALRTLLASPSNE	EPHA5	46	P54756
ASSESSLDICFLRPV	ARHGEF33	646	A8MVX0
SESFSPDLFVLCAEQ	CFAP46	41	Q8IYW2
LSFSLTCLLPENRAS	CD300LD-AS1	6	Q96MU5
FRRDSLFCPDELDSL	ACAP3	576	Q96P50
DDNCLALTPLRVFTA	C1orf74	191	Q96LT6
SLARIPETSLDCLEN	DNMBP	316	Q6XZF7
LFCDLSTPLAQFRED	CAPN10	26	Q9HC96
LETLSTRDFICPNSN	ANKRD12	1426	Q6UB98
ASLARDCTLFLTSPN	CCDC87	156	Q9NVE4
EPAFLCLLSADSFSR	CCNP	171	Q9H8S5
SSNPASLCLYDRVLE	CDHR4	381	A6H8M9
PIETFLLGSCASDRN	DCAF13	206	Q9NV06
NLAPVSACDDFERAL	ARRDC3	361	Q96B67
SCFVTPDLARDLAND	AP3D1	136	O14617
CLNVLSRLLFSSDPD	KPNA5	256	O15131
CSQDFLLFSPEVESL	NFE2L1	371	Q14494
PCLASAAEALTREFS	R3HCC1	361	Q9Y3T6
DSCFTENTPLLRNSL	OCA2	91	Q04671
LPESCFDSGLSTLRD	RASEF	431	Q8IZ41
VLCLTLFDRDQFSPD	ITSN2	1631	Q9NZM3
EACRALENPDTASLL	PTPN23	216	Q9H3S7
LFELDATTLQRADCL	ITPR2	366	Q14571
SDESLPFDLRASFCR	ITPR2	766	Q14571
SLSARNITEPLCSLD	LLGL1	936	Q15334
PSSEDLLLTLFQLCA	LTN1	841	O94822
EDIFLFSCNLSEASP	LTN1	1201	O94822
CLASARSSTDPIIFL	GPR82	296	Q96P67
FDVNDCSRPLLDLAS	LRP12	786	Q9Y561
LDECRTPLDFSNTVA	NLRC3	221	Q7RTR2
SQPLSGFSARCLEDE	MTMR7	206	Q9Y216
ANNTEESLFRICSPL	RPS6KC1	811	Q96S38
ESLFRICSPLSGANE	RPS6KC1	816	Q96S38
PDYLLCLSRLASSTD	GPC2	186	Q8N158
LQLCPALDTRDDLFA	GARIN4	151	Q8IYT1
SDARDCDFHALPQLL	LRRN2	106	O75325
LGPSLEDLFDLCDRT	CSNK1G1	121	Q9HCP0
LLSTPSQSDALRACF	DUX5	51	Q96PT3
SALLPCDLLSDQSED	KCNT1	701	Q5JUK3
NIVSDLFSPDECLDT	FSIP2	3701	Q5CZC0
SCSFIDLRFIPDDIT	ESF1	461	Q9H501
PDKLSDCDDSIALSF	EID3	136	Q8N140
DEDSPLVTLSFALCT	PCNX2	1621	A6NKB5
DDSALCAFPIRAINL	PLXNA2	351	O75051
FTCLDRPALDSLIRD	KCNK17	66	Q96T54
FDNLHDDPCLLTNRS	EPX	351	P11678
LDLFDNIALTPECAS	C19orf85	126	A0A1B0GUS0
TPFDVESDSFCLRNI	DNAH8	1371	Q96JB1
IDCRSLETSLVPLSD	GALK1	201	P51570
FTLSCAEPATLQLDT	NRXN2	91	Q9P2S2
FCSENTDDLLLRPTQ	LIPC	466	P11150
SLDCREAFRLLSPTE	DPP3	16	Q9NY33
CLLESLFQSDPESDE	FAM161B	81	Q96MY7
PLNDLFRCNSLSTLE	LAMP2	146	P13473
ASQAATICSPDFLLD	KNTC1	1136	P50748
CTDRSLSPDLQDALQ	LHX5	136	Q9H2C1
SFETLPNISDLCLRD	MTFR1L	41	Q9H019
SSDRCSALLQVIFSP	GBP3	401	Q9H0R5
SCLRALSPFAESSQL	TWNK	76	Q96RR1
FELLIPFSCEDLSSL	NLRX1	191	Q86UT6
DPECRELLLDFANSS	OSTM1	81	Q86WC4
TLLREDANLPRDSCL	MMEL1	286	Q495T6
PSLEDLFDLCDRTFS	CSNK1G3	121	Q9Y6M4
SVSCPLLSRDAVDFL	EPS8L2	366	Q9H6S3
DDVFNCNLSPRSSLT	MEDAG	266	Q5VYS4
CPNASFTDLAEIVSR	PNPLA7	1231	Q6ZV29
ELCSDLFRSTLEPVE	HSPA7	306	P48741
FLSDQSLETLLDCLP	NLRC5	1146	Q86WI3
DRCLPFLISTDGDSN	PTPRU	1216	Q92729
SPLESSFQLEVDVLC	KICS2	181	Q96MD2
DFAPLLELSCSDISV	OR5P2	176	Q8WZ92
SCPSTRLLTLEEAQA	ARHGAP33	536	O14559
PEQSLRDAITLDLFC	CFAP119	111	A1A4V9
PQTFISTDDLLDCLV	HSPBAP1	456	Q96EW2
SCEQVRAFPALTSLD	CD14	186	P08571
ALSFLVLLEDESTPC	ESPL1	171	Q14674
DFSRFPLDTQTCSLE	GABRR1	201	P24046
SDPSQACLFVLSLDT	EXT1	146	Q16394
ACLFVLSLDTLDRDQ	EXT1	151	Q16394
SELSACFSRLLDPQN	BAMBI	46	Q13145
SAVCRDLFTASNDPL	FBXO7	356	Q9Y3I1
LIAEASASDRCLTDP	GALNT8	546	Q9NY28
SIFRCLDPALTIAAS	DHX57	1076	Q6P158
DLRLCRAPDSDTASS	C2CD4D	131	B7Z1M9
SDSFVPLLRDCTNSD	GALNT12	556	Q8IXK2
LLGSFADNELSPECL	PRMT5	436	O14744
LLSTPSQSDALRACF	DUX3	51	Q96PT4
LSDAILPSAQCAERI	ATG9B	261	Q674R7
SLDRASLPCSQEEAT	HASPIN	211	Q8TF76
RDLPEELSLSFNATC	ITGB3	386	P05106
LLAVPSCDISLTDRD	KANK2	791	Q63ZY3
FPDLLSRTAVLDCTA	DALRD3	456	Q5D0E6
SATLFVDCNRIESLP	COL9A1	191	P20849
SRDSPLFDFIESCLR	COPG1	246	Q9Y678
DLITCLDTASNFLEP	DCBLD2	191	Q96PD2
SECPTLFVDAETLLS	FRY	2751	Q5TBA9
RALLSQTSPLCALEE	LBX1	76	P52954
ELCSDLFRSTLEPVE	HSPA6	306	P17066
SDPNLVVFLDTCRAS	CUZD1	431	Q86UP6
QDSLAQCADFRSSLP	HIRA	861	P54198
LDFERTLGLSSPCDN	DUSP6	341	Q16828
LLDSSENCDRLSSSP	RPRD2	896	Q5VT52
FDCVDPLASLDTNRS	SLC22A2	101	O15244
PIFTTAIDDRCELSS	EIF4G3	291	O43432
DLDETSDPALLARCS	IFT140	1116	Q96RY7
SDPALLARCSDFFIE	IFT140	1121	Q96RY7
SAARFCLNLTPEAVL	PRR18	131	Q8N4B5
NLPSDESCLSLDDLA	CNST	591	Q6PJW8
SSEDNLSLVCLPRSE	DRICH1	101	Q6PGQ1
DCLFRLAQPDSLSKE	MIF4GD	131	A9UHW6
DLSFNSLETLPACVL	PIDD1	131	Q9HB75
VASLSRDLQFPCLTS	NYNRIN	1701	Q9P2P1
PQLDLSIDSLDLSCE	NUMA1	1716	Q14980
AFSPSLQLSREDCLN	PCDHA12	771	Q9UN75
LVLSCFSDRSPLFSE	ABCC1	186	P33527
SDPDTSLFINVCRDI	IGF2R	201	P11717
ELVRTDSPNFLCSVL	RUNX1	61	Q01196
AELVRTDSPNFLCSV	RUNX2	111	Q13950
FCRTLEDILADAPES	STING1	291	Q86WV6
VPDALLASDTCLDIS	PRUNE2	2281	Q8WUY3
DTDCSVSRNLPSSFL	MAP3K21	856	Q5TCX8
LVDARICAPSSSLFS	PLEKHG4	251	Q58EX7
QLLRDLDSCNSDPVA	PLEKHG3	151	A1L390
SRDEACLTVSFSRPL	RABGGTA	251	Q92696
SLSEAALAADPRRFC	HIF3A	396	Q9Y2N7
LSSSLPDDLLQRCVD	SMG1	786	Q96Q15
NRLSTEDCLIPLFSE	SMG1	1366	Q96Q15
CPTIQESLSLSFEFD	NANOGNB	126	Q7Z5D8
TSFLKAQLLCSRPDD	SEMA4B	301	Q9NPR2
CDASLAEEASSLPLV	PREX1	1116	Q8TCU6
SICFPDSLLQDEERS	PRR12	931	Q9ULL5
LALLAATCSRIESPN	SP1	61	P08047
ILDSQLLPCDSSEAD	STXBP4	281	Q6ZWJ1
LTANPELIDRLACLS	DIS3	201	Q9Y2L1
ARLLELFTDLSCNPE	BROX	41	Q5VW32
PRLFCSVSLLTNFED	AMMECR1	211	Q9Y4X0
EDETFPCDLIFLSSN	ATP11A	156	P98196
FCASDAPERSLLADR	C17orf64	146	Q86WR6
AFCPQLDDSTVAREL	RETREG3	266	Q86VR2
CFLEEASSDQFLPSL	TNRC18	1321	O15417
FEPSTESLQFLLDTC	UBA3	56	Q8TBC4
SEEQLFRSALSVCPL	TMTC4	466	Q5T4D3
CQADSPRTSVFLEEL	TXNDC16	51	Q9P2K2
RSDFLSLPFQAIECS	TDRKH	406	Q9Y2W6
SDPTLAAIFEICREL	TEP1	266	Q99973
SSAPRCALFAEDSIV	TIAM2	561	Q8IVF5
FLALRDQVPTLASCS	MYCL	301	P12524
CLASLQLFEEDLGSP	RP1L1	1121	Q8IWN7
LVRLSCSDDTAPESQ	PAPLN	926	O95428
TDPSNSERFCLGLLS	SMAD3	261	P84022
ATSVLLADPCFQLRS	RNF123	1171	Q5XPI4
DAIRDNCLDLSPRSL	SYCP2	1091	Q9BX26
SLADLTAQFSLPCEV	THEMIS2	441	Q5TEJ8
LSLLRSTPAASCEEE	SELENON	131	Q9NZV5
DCTDSLKLREPNFTL	TMEM131	1001	Q92545
RLPSSADVEFCLSLT	TYR	311	P14679
FLSCQRSPAAAILEL	UNC5CL	446	Q8IV45
LSCSEASAEEALLPA	TMPRSS5	91	Q9H3S3
IRSEDCILSLDSDPL	WAPL	246	Q7Z5K2
ELFDSLSPEAVRCTI	RLBP1	126	P12271
LRLCTLDPDDVASTT	PIM3	306	Q86V86
SSSLRCADLTLPEDI	TBCK	291	Q8TEA7
PQLCARLSDLLTDFV	USP38	141	Q8NB14
ETALEACSLPSSRND	PLCB1	186	Q9NQ66
AALETDENLLLCAPT	SNRNP200	491	O75643
VCLPDRETAASLLQA	F2	481	P00734
SPLSSETRFDLCDDL	USP17L7	41	P0C7H9
LSPSEEVRCTQDFLS	TASOR2	1171	Q5VWN6
LEERSPLLFTLAENC	TTC27	196	Q6P3X3
DELLECLSPATSRTF	USP7	956	Q93009
EPINLDSCLRAFTSE	USP32	1231	Q8NFA0
SPLSSEARVDLCDDL	USP17L2	41	Q6R6M4
AQCASRIDLTPFLVD	ZAN	2151	Q9Y493
DCDVPLAELTFSRLN	VPS13D	2721	Q5THJ4
PFSQRCLEAVSLEDT	KLHL35	476	Q6PF15
TLQSPLESLELAFCA	LRRC14	306	Q15048
RTFENLDACEVLFSP	MYO7A	336	Q13402
LDACEVLFSPSLATA	MYO7A	341	Q13402