Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionankyrin binding

SPTB SPTBN1

2.63e-0423212GO:0030506
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETD1B DOT1L

9.70e-0444212GO:0140938
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SETD1B DOT1L

2.30e-0368212GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SETD1B DOT1L

2.37e-0369212GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETD1B DOT1L

2.51e-0371212GO:0042054
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTB SPTBN1

3.45e-059212GO:0014731
GeneOntologyCellularComponentspectrin

SPTB SPTBN1

3.45e-059212GO:0008091
HumanPhenoShort uvula

WDR35 SPTBN1

8.32e-06392HP:0010812
DomainSpectrin_bsu

SPTB SPTBN1

7.21e-064212IPR016343
DomainACTININ_2

SPTB SPTBN1

3.00e-0423212PS00020
DomainActinin_actin-bd_CS

SPTB SPTBN1

3.00e-0423212IPR001589
DomainACTININ_1

SPTB SPTBN1

3.00e-0423212PS00019
DomainSpectrin

SPTB SPTBN1

3.00e-0423212PF00435
DomainSpectrin_repeat

SPTB SPTBN1

4.80e-0429212IPR002017
DomainSpectrin/alpha-actinin

SPTB SPTBN1

5.85e-0432212IPR018159
DomainSPEC

SPTB SPTBN1

5.85e-0432212SM00150
DomainCH

SPTB SPTBN1

2.40e-0365212SM00033
DomainCH

SPTB SPTBN1

2.78e-0370212PF00307
Domain-

SPTB SPTBN1

2.86e-03712121.10.418.10
DomainCH

SPTB SPTBN1

3.02e-0373212PS50021
DomainCH-domain

SPTB SPTBN1

3.18e-0375212IPR001715
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTB SPTBN1

5.41e-0510162MM15112
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTB SPTBN1

5.51e-0431162M877
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTB SPTBN1

8.29e-0438162MM14969
PathwayKEGG_LYSINE_DEGRADATION

SETD1B DOT1L

1.11e-0344162M13720
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

SETD1B DOT1L

1.21e-0346162MM14933
Pubmed

A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.

SPTB SPTBN1

1.04e-06321211294830
Pubmed

β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.

SPTB SPTBN1

1.04e-06321232425157
Pubmed

Developmental expression of brain beta-spectrin isoform messenger RNAs.

SPTB SPTBN1

1.04e-0632121467942
Pubmed

Localization of the twitcher (twi) mutation on mouse chromosome 12.

GALC SPTB

1.04e-0632128281019
Pubmed

The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.

SPTB SPTBN1

1.04e-0632128479293
Pubmed

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

SPTB SPTBN1

2.08e-06421221566095
Pubmed

Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.

SPTB SPTBN1

2.08e-06421212820899
Pubmed

Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.

SPTB SPTBN1

2.08e-0642123862089
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTB SPTBN1

2.08e-06421221412925
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

SPTB SPTBN1

1.56e-051021222159418
Pubmed

Refinement of the DNA marker maps of mouse chromosome 12.

SPTB CHGA

1.56e-05102128088780
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTB SPTBN1

1.90e-051121217607528
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTB SPTBN1

2.70e-051321218796539
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTB SPTBN1

5.28e-051821212119179
Pubmed

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.

SPTB SPTBN1

6.55e-052021218723693
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTB SPTBN1

1.03e-04252128493579
Pubmed

New nomenclature for chromatin-modifying enzymes.

SETD1B DOT1L

5.43e-045721218022353
Pubmed

USP7 controls NGN3 stability and pancreatic endocrine lineage development.

SPTBN1 CHGA

5.62e-045821237117185
CytobandEnsembl 112 genes in cytogenetic band chr12q24

TCHP SETD1B

1.53e-02415212chr12q24
GeneFamilyEF-hand domain containing|Spectrins

SPTB SPTBN1

1.17e-0571421113
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD1B DOT1L

3.08e-0434142487
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTB SPTBN1

1.07e-02206142682
DrugLeupeptin hydrochloride

SPTB SPTBN1 SPPL2A CHGA CAPN3

4.38e-06276215CID000003910
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

GALC SPTB SPTBN1 GMIP

2.84e-051962147495_DN
Drugalph a-

SPTB SPTBN1 CAPN3

3.41e-0569213CID000234384
DrugDFT-D

FCGR3A CHGA

5.32e-0512212CID000124866
DrugAC1MMOKY

GALC CAPN3

5.32e-0512212CID003289210
DrugADPribulose

SPTB SPTBN1

6.28e-0513212CID000197570
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTB SPTBN1

2.36e-064192DOID:0050882 (implicated_via_orthology)
Diseasebasophil percentage of leukocytes

FCGR3A GALC SPTBN1 GMIP

1.58e-05243194EFO_0007992
Diseasegamma-linolenic acid measurement

CHGA DOT1L

1.08e-0424192EFO_0007762
DiseaseIgA glomerulonephritis (is_implicated_in)

FCGR3A CHGA

1.69e-0430192DOID:2986 (is_implicated_in)
Diseasebasophil count

FCGR3A GALC CAPN3 GMIP

2.26e-04483194EFO_0005090
Diseasemyeloid white cell count

SPTBN1 SPPL2A CHGA SETD1B DOT1L

2.56e-04937195EFO_0007988
Diseasefibrinogen measurement, tissue plasminogen activator measurement

SPPL2A CAPN3

3.83e-0445192EFO_0004623, EFO_0004791
Diseasefibrinogen measurement, plasminogen activator inhibitor 1 measurement

SPPL2A CAPN3

3.83e-0445192EFO_0004623, EFO_0004792
DiseaseIschemic stroke, fibrinogen measurement

SPPL2A CAPN3

5.72e-0455192EFO_0004623, HP_0002140
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

SPPL2A CAPN3

5.93e-0456192EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseasefibrinogen measurement, factor VII measurement

SPPL2A CAPN3

6.36e-0458192EFO_0004619, EFO_0004623
Diseasefasting blood insulin measurement

SPTB UBXN11

8.98e-0469192EFO_0004466
Diseasemonocyte count

FCGR3A SPTBN1 UBXN11 SPPL2A CAPN3

1.22e-031320195EFO_0005091
Diseasetriglyceride measurement, alcohol drinking

CAPN3 GMIP

1.84e-0399192EFO_0004329, EFO_0004530
Diseasetriglyceride measurement, alcohol consumption measurement

CAPN3 GMIP

1.91e-03101192EFO_0004530, EFO_0007878
Diseasefibrinogen measurement

SPPL2A CAPN3

2.22e-03109192EFO_0004623
Diseasecardiovascular disease

TCHP DDX23 TRIM48

2.97e-03457193EFO_0000319

Protein segments in the cluster

PeptideGeneStartEntry
WKEEKSFWEMEKSFR

CCDC70

101

Q6NSX1
ETMDREFRKWMKWYG

DOT1L

196

Q8TEK3
TEIEKWRKEFKEQWM

GMIP

186

Q9P107
RWDDRHWSQKKLDEM

DDX23

351

Q9BUQ8
ARKERPADMDKAWWK

C20orf144

16

Q9BQM9
WKSRSTMEKYFREWK

DCLRE1A

1021

Q6PJP8
STRDWKDHKFKWRKD

FCGR3A

236

P08637
DRWKDWSFVDKDEKA

CAPN3

371

P20807
FRGYEWWLMKEAKKR

GALC

126

P54803
KWKMEFDTRERWENP

NDUFS4

96

O43181
EWAAEEHWEKLLKKM

TRIM48

146

Q8IWZ4
RAFDEWWDKKERMAK

SETD1B

891

Q9UPS6
TEKRKEMIDKWEDRW

SPTBN1

1996

Q01082
GWDDMEKLWKHLFER

ACTRT1

81

Q8TDG2
RLSKEWEDSKRWSKM

CHGA

331

P10645
WEDSKRWSKMDQLAK

CHGA

336

P10645
ASVVAWRRKEMKKFW

SPPL2A

476

Q8TCT8
WKRKMEWWDKSEESE

SPDYE1

101

Q8NFV5
REEAKEMWEKREAEW

TCHP

351

Q9BT92
EMWEKREAEWARERS

TCHP

356

Q9BT92
RKEMNEKWEARWERL

SPTB

1991

P11277
LERRDVWDMKWAKDN

WDR35

591

Q9P2L0
EHGERDWMTAKKFWK

UBXN11

171

Q5T124