Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	amyloid-beta binding	CACNA1A CACNA1B CALCR LILRB1	3.63e-04	102	66	4	GO:0001540
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1B	3.82e-04	9	66	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1B	3.82e-04	9	66	2	GO:0099626
GeneOntologyMolecularFunction	cytidine deaminase activity	APOBEC3D APOBEC3B	8.20e-04	13	66	2	GO:0004126
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1B SLC24A4 TMCO1	8.79e-04	129	66	4	GO:0005262
GeneOntologyMolecularFunction	MHC protein binding	MARCHF8 MARCHF1 LILRB1	9.35e-04	58	66	3	GO:0042287
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1B	9.54e-04	14	66	2	GO:0008331
GeneOntologyCellularComponent	Golgi membrane	RNF121 AP1S1 MARCHF8 ARFGEF2 AP1S2 ST3GAL3 RNF175 TMCO1 DOP1B	4.19e-04	721	66	9	GO:0000139
GeneOntologyCellularComponent	lysosomal membrane	AP1S1 MARCHF8 HGSNAT AP1S2 MARCHF1 LMBRD1 WDR59	6.23e-04	462	66	7	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	AP1S1 MARCHF8 HGSNAT AP1S2 MARCHF1 LMBRD1 WDR59	6.23e-04	462	66	7	GO:0098852
GeneOntologyCellularComponent	AP-1 adaptor complex	AP1S1 AP1S2	6.35e-04	12	66	2	GO:0030121
GeneOntologyCellularComponent	vacuolar membrane	AP1S1 MARCHF8 HGSNAT AP1S2 MARCHF1 LMBRD1 WDR59	1.07e-03	507	66	7	GO:0005774
Domain	VDCC_a1su_IQ	CACNA1A CACNA1B	2.55e-04	7	66	2	IPR014873
Domain	GPHH	CACNA1A CACNA1B	2.55e-04	7	66	2	PF16905
Domain	GPHH_dom	CACNA1A CACNA1B	2.55e-04	7	66	2	IPR031649
Domain	Ca_chan_IQ	CACNA1A CACNA1B	2.55e-04	7	66	2	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1B	2.55e-04	7	66	2	PF08763
Domain	AP_complex_ssu	AP1S1 AP1S2	2.55e-04	7	66	2	IPR016635
Domain	MARCH-like	MARCHF8 MARCHF1	3.40e-04	8	66	2	IPR033275
Domain	CLAT_ADAPTOR_S	AP1S1 AP1S2	4.36e-04	9	66	2	PS00989
Domain	VDCCAlpha1	CACNA1A CACNA1B	5.43e-04	10	66	2	IPR002077
Domain	RINGv	MARCHF8 MARCHF1	6.63e-04	11	66	2	PF12906
Domain	ZF_RING_CH	MARCHF8 MARCHF1	6.63e-04	11	66	2	PS51292
Domain	APOBEC_N	APOBEC3D APOBEC3B	7.93e-04	12	66	2	PF08210
Domain	Clathrin_sm-chain_CS	AP1S1 AP1S2	7.93e-04	12	66	2	IPR000804
Domain	APOBEC_N	APOBEC3D APOBEC3B	7.93e-04	12	66	2	IPR013158
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3D APOBEC3B	1.09e-03	14	66	2	IPR016192
Domain	Znf_RING/FYVE/PHD	RNF121 JADE2 MARCHF8 RNF175 ZNF598 MARCHF1 WDR59	1.15e-03	459	66	7	IPR013083
Domain	AP_mu_sigma_su	AP1S1 AP1S2	1.43e-03	16	66	2	IPR022775
Domain	Clat_adaptor_s	AP1S1 AP1S2	1.43e-03	16	66	2	PF01217
Domain	Znf_RING-CH	MARCHF8 MARCHF1	1.62e-03	17	66	2	IPR011016
Domain	RINGv	MARCHF8 MARCHF1	1.62e-03	17	66	2	SM00744
Domain	Cytidine_deaminase-like	APOBEC3D APOBEC3B	1.62e-03	17	66	2	IPR016193
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3D APOBEC3B	1.62e-03	17	66	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3D APOBEC3B	1.62e-03	17	66	2	IPR002125
Domain	Ig_2	FCRLB IL1R1 LILRB1	2.20e-03	73	66	3	PF13895
Domain	IQ	IQCA1 ASPM CAMTA2	2.95e-03	81	66	3	SM00015
Domain	TRYPSIN_SER	KLK8 TMPRSS11F KLK13	3.98e-03	90	66	3	IPR033116
Domain	IQ_motif_EF-hand-BS	IQCA1 ASPM CAMTA2	3.98e-03	90	66	3	IPR000048
Domain	IQ	IQCA1 ASPM CAMTA2	4.36e-03	93	66	3	PS50096
Domain	Longin-like_dom	AP1S1 AP1S2	4.38e-03	28	66	2	IPR011012
Domain	-	RNF121 JADE2 MARCHF8 RNF175 ZNF598 MARCHF1	5.02e-03	449	66	6	3.30.40.10
Domain	TRYPSIN_HIS	KLK8 TMPRSS11F KLK13	5.80e-03	103	66	3	IPR018114
Domain	Znf_RING	RNF121 MARCHF8 RNF175 ZNF598 MARCHF1	5.89e-03	326	66	5	IPR001841
Domain	TRYPSIN_SER	KLK8 TMPRSS11F KLK13	6.27e-03	106	66	3	PS00135
Domain	TRYPSIN_HIS	KLK8 TMPRSS11F KLK13	6.44e-03	107	66	3	PS00134
Domain	Peptidase_S1A	KLK8 TMPRSS11F KLK13	7.48e-03	113	66	3	IPR001314
Domain	TRYPSIN_DOM	KLK8 TMPRSS11F KLK13	7.85e-03	115	66	3	PS50240
Domain	zf-C3HC4	RNF121 MARCHF8 RNF175 MARCHF1	8.00e-03	223	66	4	PF00097
Domain	Tryp_SPc	KLK8 TMPRSS11F KLK13	8.23e-03	117	66	3	SM00020
Domain	Trypsin	KLK8 TMPRSS11F KLK13	9.02e-03	121	66	3	PF00089
Domain	Trypsin_dom	KLK8 TMPRSS11F KLK13	9.02e-03	121	66	3	IPR001254
Domain	Peptidase_S1_PA	KLK8 TMPRSS11F KLK13	9.43e-03	123	66	3	IPR009003
Pubmed	Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.	CACNA1A CACNA1B	3.66e-06	2	67	2	23426690
Pubmed	Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.	CACNA1A CACNA1B	3.66e-06	2	67	2	23376566
Pubmed	CaV 2.1 α1 subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.	CACNA1A CACNA1B	3.66e-06	2	67	2	38155373
Pubmed	MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.	MARCHF8 MARCHF1	3.66e-06	2	67	2	21757542
Pubmed	Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation.	SLC24A4 WDR72	3.66e-06	2	67	2	26247047
Pubmed	Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.	CACNA1A CACNA1B	3.66e-06	2	67	2	15050706
Pubmed	Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	32641479
Pubmed	APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	27602762
Pubmed	A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	22691411
Pubmed	Studies on the restriction of murine leukemia viruses by mouse APOBEC3.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	22666481
Pubmed	Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection.	MARCHF8 MARCHF1	1.10e-05	3	67	2	27503069
Pubmed	APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	24577894
Pubmed	APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	16648136
Pubmed	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	23533681
Pubmed	Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	1541833
Pubmed	In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	27356895
Pubmed	Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.	CACNA1A CACNA1B	1.10e-05	3	67	2	29466725
Pubmed	IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	23315078
Pubmed	Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	25589647
Pubmed	Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	23671100
Pubmed	Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	31518043
Pubmed	Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.	MARCHF8 MARCHF1	1.10e-05	3	67	2	23606747
Pubmed	APOBEC3 signature mutations in chronic lymphocytic leukemia.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	24840555
Pubmed	Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.	CACNA1A CACNA1B	1.10e-05	3	67	2	24394417
Pubmed	Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	9765497
Pubmed	Biochemical and biological studies of mouse APOBEC3.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	24453360
Pubmed	APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	23449789
Pubmed	APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	18434399
Pubmed	Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	19153238
Pubmed	Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	18772436
Pubmed	Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain.	MARCHF8 MARCHF1	1.10e-05	3	67	2	38299743
Pubmed	Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	18786991
Pubmed	Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	286744
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1B	1.10e-05	3	67	2	38996073
Pubmed	Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	24725948
Pubmed	The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	20702647
Pubmed	Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	20980520
Pubmed	Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	284359
Pubmed	Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	20617165
Pubmed	Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	31801862
Pubmed	Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	39208378
Pubmed	Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	31943071
Pubmed	Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1.	MARCHF8 MARCHF1	1.10e-05	3	67	2	23300075
Pubmed	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	20566830
Pubmed	Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	7884913
Pubmed	N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	25505062
Pubmed	Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	31595054
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1B	1.10e-05	3	67	2	24523520
Pubmed	Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	17967065
Pubmed	Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	20335265
Pubmed	Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	29593034
Pubmed	Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	31830125
Pubmed	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	21998583
Pubmed	Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.	CACNA1A CACNA1B	1.10e-05	3	67	2	29208674
Pubmed	Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	38115583
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1A CACNA1B	1.10e-05	3	67	2	26507659
Pubmed	Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	2157836
Pubmed	Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	35458563
Pubmed	Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	22275865
Pubmed	Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	293683
Pubmed	Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	19150103
Pubmed	Initial sequencing and comparative analysis of the mouse genome.	APOBEC3D APOBEC3B	1.10e-05	3	67	2	12466850
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1B	2.19e-05	4	67	2	32616470
Pubmed	Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.	CACNA1A CACNA1B	2.19e-05	4	67	2	26283199
Pubmed	Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	18983852
Pubmed	APOBEC3 regulates keratinocyte differentiation and expression of Notch3.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	31400166
Pubmed	Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.	MARCHF8 MARCHF1	2.19e-05	4	67	2	27503071
Pubmed	Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	23725696
Pubmed	APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	21985787
Pubmed	APOBEC3A functions as a restriction factor of human papillomavirus.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	25355878
Pubmed	Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	26253512
Pubmed	The HLA-DRalpha chain is modified by polyubiquitination.	MARCHF8 MARCHF1	2.19e-05	4	67	2	19117940
Pubmed	Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	17020885
Pubmed	Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	20375169
Pubmed	APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	21147467
Pubmed	Mice deficient in APOBEC2 and APOBEC3.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	16055735
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1A CACNA1B	2.19e-05	4	67	2	15728831
Pubmed	The incorporation of APOBEC3 proteins into murine leukemia viruses.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	18572219
Pubmed	Restriction of foamy viruses by APOBEC cytidine deaminases.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	16378963
Pubmed	Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	32893454
Pubmed	The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.	CACNA1A CACNA1B	2.19e-05	4	67	2	25483588
Pubmed	AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.	AP1S1 AP1S2	2.19e-05	4	67	2	2040623
Pubmed	Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	15269786
Pubmed	Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	24821801
Pubmed	Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	20363737
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1B	2.19e-05	4	67	2	37141091
Pubmed	Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	29343743
Pubmed	APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	15674295
Pubmed	Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	21873525
Pubmed	Interactions of Rabconnectin-3 with Cav2 calcium channels.	CACNA1A CACNA1B	2.19e-05	4	67	2	31253182
Pubmed	AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.	AP1S1 AP1S2	2.19e-05	4	67	2	27411398
Pubmed	APOBEC3 enzymes restrict marginal zone B cells.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	25501566
Pubmed	Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	18702815
Pubmed	HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	20538015
Pubmed	σ1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.	AP1S1 AP1S2	2.19e-05	4	67	2	24928897
Pubmed	The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	38049664
Pubmed	AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.	AP1S1 AP1S2	2.19e-05	4	67	2	20203623
Pubmed	Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	26846717
Pubmed	Vaccinia virus replication is not affected by APOBEC3 family members.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	17052331
Pubmed	Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.	APOBEC3D APOBEC3B	2.19e-05	4	67	2	28415995
Cytoband	1q31	ASPM PFKFB2	3.53e-04	19	67	2	1q31
GeneFamily	Ring finger proteins\|Membrane associated ring-CH-type fingers	MARCHF8 MARCHF1	3.74e-04	11	48	2	60
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3B	4.48e-04	12	48	2	406
GeneFamily	Kallikreins	KLK8 KLK13	8.09e-04	16	48	2	616
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1B	2.15e-03	26	48	2	253
GeneFamily	WD repeat domain containing	NWD1 WDR59 DCAF5 WDR72	5.09e-03	262	48	4	362
GeneFamily	Ring finger proteins	RNF121 MARCHF8 RNF175 MARCHF1	6.03e-03	275	48	4	58
GeneFamily	Proteases, serine	KLK8 TMPRSS11F	1.22e-02	63	48	2	738
ToppCell	Control-Lymphocyte-B-Plasmablast\|Control / Disease, Lineage and Cell Type	ABCC4 RASGRP3 ASPM APOBEC3B RGS13	4.59e-06	162	67	5	67b32c40cc180c5ebbfd901a417b5be469500110
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADCY4 PIK3C2B RASGRP3 GRB10 DGKH	8.75e-06	185	67	5	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ADCY4 SLC24A4 RASGRP3 DGKH	1.05e-05	192	67	5	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LIFR ADCY4 PIK3C2B DGKH BRINP1	1.10e-05	194	67	5	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIFR PIK3C2B RASGRP3 GRB10 DGKH	1.10e-05	194	67	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	Nasal_Brush-Immune\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SLC24A4 AP1S2 MARCHF1 LILRB1 RGS13	1.10e-05	194	67	5	3135bc4a8112c5dee108e3b8e775f508b65191f1
ToppCell	Sepsis-Int-URO-Lymphocyte-B-Plasmablast\|Int-URO / Disease, condition lineage and cell class	PIK3C2B RASGRP3 ASPM APOBEC3B RGS13	1.16e-05	196	67	5	e65b47d0ce1a5dd05f5f50e1639c8ec76fb42dc8
ToppCell	medial-Hematologic-Intermediate_Monocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC24A4 AP1S2 MARCHF1 LILRB1 APOBEC3B	1.21e-05	198	67	5	dbd7869483c5a67944cb94ced0ee2c7b999adc2e
ToppCell	medial-Hematologic-Intermediate_Monocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC24A4 AP1S2 MARCHF1 LILRB1 APOBEC3B	1.21e-05	198	67	5	8f64bb5cd8c3e2d5ef651821b0d59f67d1ca1a12
ToppCell	medial-2-Hematologic-Intermediate_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC24A4 AP1S2 MARCHF1 LILRB1 APOBEC3B	1.21e-05	198	67	5	432a26ace5b486695c9a933c0d44b73305b01ded
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-B-B_intermediate\|Leuk-UTI / Disease, condition lineage and cell class	C1orf220 RASGRP3 MARCHF1 RGS13 DOP1B	1.24e-05	199	67	5	e3edf3bcb381dbcf0092bdc2ee93ba852d32af3f
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ABCC4 SLC24A4 IQCA1 KLK8	9.45e-05	158	67	4	9e0589f770920f8ac41cfe5cd0a29e9e7a04a308
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1A CACNA1B NWD1 MARCHF1	9.68e-05	159	67	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ABCC4 SLC24A4 IQCA1 KLK8	1.04e-04	162	67	4	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC24A4 FCRLB TMPRSS11F MARCHF1	1.14e-04	166	67	4	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A CACNA1B NWD1 SLC34A1	1.17e-04	167	67	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCNX3 PIK3C2B POPDC3 SFI1	1.17e-04	167	67	4	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 CALCR MARCHF1 WDR72	1.22e-04	169	67	4	4b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 CALCR MARCHF1 WDR72	1.22e-04	169	67	4	a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	1.25e-04	170	67	4	3e52d40b0c36ab5b627a2dad025248901af8a320
ToppCell	facs-Lung-EPCAM-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LINS1 ADCY4 AP1S1 PRPF38A	1.25e-04	170	67	4	12203d4410f38cc933d9f160b5fb76828df94119
ToppCell	facs-Lung-EPCAM-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LINS1 ADCY4 AP1S1 PRPF38A	1.25e-04	170	67	4	f9decb3bf3bf6d4996b0ac27af768236e116aac5
ToppCell	Monocytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SLC24A4 AP1S2 MARCHF1 LILRB1	1.25e-04	170	67	4	4e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RASGRP3 GRB10 DGKH	1.28e-04	171	67	4	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	Immune_cells-B_cell\|Immune_cells / Lineage and Cell class	RASGRP3 PFKFB2 MARCHF1 LMBRD1	1.31e-04	172	67	4	b646894b691a99bf2742bd9da8e578dff0e87f1f
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.37e-04	174	67	4	2f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.37e-04	174	67	4	01eff218e71a04201189a0313aaf91437fffed95
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	LINS1 HGSNAT SFI1 PFKFB2	1.37e-04	174	67	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.37e-04	174	67	4	f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ASPM ARFGEF2 DGKH IL1R1	1.37e-04	174	67	4	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 RASGRP3 KLK13 RGS13	1.40e-04	175	67	4	c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 RASGRP3 KLK13 RGS13	1.40e-04	175	67	4	c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 RASGRP3 KLK13 RGS13	1.40e-04	175	67	4	2f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCell	Bronchial_Biopsy-Immune-Neutrophils\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	AP1S2 MARCHF1 LILRB1 RGS13	1.53e-04	179	67	4	8c50e13927c09de05c86cd90dd6f71cee004b0d3
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.56e-04	180	67	4	243622eee35d38748e945677ff115616e763e3b4
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASGRP3 ASPM MARCHF1 RGS13	1.56e-04	180	67	4	ce2fc270f9d9110c2544083f61936b0b7d3b7eb3
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.56e-04	180	67	4	3a8d9a71efe113d1df3933902a625c0a56812074
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IQCA1 ASPM KLK8 BRINP1	1.59e-04	181	67	4	3dcb74b28f93be35ddf4de1937f7e30b25e11927
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A NWD1 SLC34A1 BRINP1	1.59e-04	181	67	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IQCA1 ASPM KLK8 BRINP1	1.59e-04	181	67	4	7679a5980011d6dfb1aaca7abf678c29b6f819bb
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ADCY4 RASGRP3 KLK8	1.63e-04	182	67	4	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	LIFR ADCY4 GRB10 IL1R1	1.66e-04	183	67	4	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	Nasal_Brush-Immune-Dendritic_cells\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SLC24A4 MARCHF1 LILRB1 RGS13	1.66e-04	183	67	4	b1daec831990a53e846c089cebfcf4f8440820e4
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	CACNA1A ARFGEF2 MLXIP IL1R1	1.70e-04	184	67	4	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.73e-04	185	67	4	eb338fcda0b237c2e0b9b4b0daf51febbfe1d79c
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.73e-04	185	67	4	c31bb53852caf36964b83b28bcaee07b679da779
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIFR MARCHF8 PTPN21 DCAF5	1.77e-04	186	67	4	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.77e-04	186	67	4	664295cd508dc3894d55da7e9d9cd75bf1432f52
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ADCY4 PIK3C2B RASGRP3	1.77e-04	186	67	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.77e-04	186	67	4	b30eb0c1673ca1ebc9b6248877d86fd6d6d14470
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIFR MARCHF8 PTPN21 DCAF5	1.77e-04	186	67	4	02418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIK3C2B ESYT1 RASGRP3 DOP1B	1.81e-04	187	67	4	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	Control-Endothelial_cells-Endothelial_cells_(general)\|Control / group, cell type (main and fine annotations)	LIFR ADCY4 GRB10 BRINP1	1.81e-04	187	67	4	fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIK3C2B ESYT1 RASGRP3 DOP1B	1.81e-04	187	67	4	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADCY4 PIK3C2B RASGRP3 DGKH	1.81e-04	187	67	4	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LIFR ADCY4 RASGRP3 DGKH	1.84e-04	188	67	4	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP3 ASPM APOBEC3B RGS13	1.84e-04	188	67	4	ecba5d06cbf3254448255a2aeefffe711f43310e
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	LIFR ADCY4 PIK3C2B IL1R1	1.84e-04	188	67	4	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.84e-04	188	67	4	1f07e3ab87173426fe0c429f5c084fb3425effd3
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B RASGRP3 MARCHF1 LMBRD1	1.84e-04	188	67	4	85746f95319e494efdc1bbc24331698688d3a900
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CACNA1A RASGRP3 MARCHF1 RGS13	1.84e-04	188	67	4	ef05d2fb17fd427d46d454e67073e0e1b45bb24c
ToppCell	normal-na-Lymphocytic_B-B_atypical-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP3 MARCHF1 LILRB1 RGS13	1.84e-04	188	67	4	e5ab89030783461e9367ab87c353fb5c31911020
ToppCell	normal-na-Lymphocytic_B-B_atypical\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP3 MARCHF1 LILRB1 RGS13	1.84e-04	188	67	4	13653481d64c7a1ad833d738a3ee0bb9def7cec7
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP3 ASPM APOBEC3B RGS13	1.84e-04	188	67	4	8cf135da4d1d2500755d2809d60b41509af9fa8b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CACNA1A RASGRP3 MARCHF1 RGS13	1.88e-04	189	67	4	ebaf722738c71d5f33f72341f801c6880f4aee14
ToppCell	normal-na-Lymphocytic_B-B_plasma\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP3 ASPM APOBEC3B RGS13	1.88e-04	189	67	4	659deb617a560bcde67c75f477d30ce85aaec3c6
ToppCell	facs-Heart-LV-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 PIK3C2B RASGRP3 KLK8	1.88e-04	189	67	4	d424d2554595b2304219f7324406b401711af7c2
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 PIK3C2B RASGRP3 KLK8	1.88e-04	189	67	4	393ec5954a12d6cf67bb435dcc34ff0b14c81e9f
ToppCell	facs-Heart-LV-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 PIK3C2B RASGRP3 KLK8	1.88e-04	189	67	4	bec57459ad4bab15b2532b57722549fec2e771fb
ToppCell	Monocytes-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	SLC24A4 AP1S2 MARCHF1 LILRB1	1.88e-04	189	67	4	22d08c7dde697f385100f72e009eeac8d19d329d
ToppCell	normal-na-Lymphocytic_B-B_plasma-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP3 ASPM APOBEC3B RGS13	1.88e-04	189	67	4	67f9a9861d2dcc128b7a69432c6b31da185e2249
ToppCell	control-Myeloid-CD14_Monocytes_2\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SLC24A4 AP1S2 MARCHF1 LILRB1	1.92e-04	190	67	4	47513757e0059e8370e49672a577f25ca842e98c
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LIFR ADCY4 PIK3C2B IL1R1	1.92e-04	190	67	4	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	IPF-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	SLC24A4 AP1S2 MARCHF1 LILRB1	1.92e-04	190	67	4	f9c2a13c7f6460e3b348581be855b7281c8f70b5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B ABCC4 DGKH MARCHF1	1.96e-04	191	67	4	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ABCC4 ARFGEF2 SFI1 DOP1B	1.96e-04	191	67	4	9454f642c3621370fa23640b631301346b300950
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	1.96e-04	191	67	4	5d6ef70cc15ec5e983a953e547e40f9c06e355fb
ToppCell	Monocytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	SLC24A4 AP1S2 MARCHF1 LILRB1	1.96e-04	191	67	4	ca0a5dc82cdef02e88fed937ca5784761896af33
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	1.96e-04	191	67	4	1c7d31684654ca6a046d8cc816af1fdc42369c57
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	1.96e-04	191	67	4	d60d81d2045c6e624bbc8b17e13a32f7921d969f
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADCY4 PIK3C2B RASGRP3 GRB10	2.00e-04	192	67	4	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	LIFR ADCY4 PIK3C2B GRB10	2.00e-04	192	67	4	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY4 ABCC4 PIK3C2B RASGRP3	2.00e-04	192	67	4	5012cc3ec0766f06af447463413422b484446c43
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Granulocytic-Neutrophil\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC24A4 AP1S2 MARCHF1 LILRB1	2.00e-04	192	67	4	e2fa1ba26d28953f0d35d95764b5dbe0b93a1191
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Granulocytic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC24A4 AP1S2 MARCHF1 LILRB1	2.00e-04	192	67	4	161f4626571b1bce5758fad1fe5ce41a4621771d
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	2.04e-04	193	67	4	cb0fb21510124883e716780bea46575620c366b8
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIFR RASGRP3 GRB10 DGKH	2.04e-04	193	67	4	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LIFR ADCY4 GRB10 IL1R1	2.04e-04	193	67	4	9ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIFR RASGRP3 GRB10 DGKH	2.04e-04	193	67	4	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	Monocytes\|World / lung cells shred on cell class, cell subclass, sample id	SLC24A4 AP1S2 MARCHF1 LILRB1	2.04e-04	193	67	4	d66d3927f8fbe1544b5cfa5ee91a7f4a0ef1e810
ToppCell	IPF-Endothelial-VE_Venous\|IPF / Disease state, Lineage and Cell class	LIFR ADCY4 GRB10 IL1R1	2.04e-04	193	67	4	29a655fa80feaabe846c90a28363b037e22d24ae
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LIFR ADCY4 DGKH BRINP1	2.04e-04	193	67	4	ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	2.04e-04	193	67	4	0c207879f994c227dcd1322faa69ec9e3749cdaa
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RASGRP3 GRB10 AP1S2	2.04e-04	193	67	4	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	2.04e-04	193	67	4	0fbbfcc803edc3cd96b35467ad5cc573af07fd67
ToppCell	IPF-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	LIFR ADCY4 GRB10 IL1R1	2.04e-04	193	67	4	ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 PIK3C2B RASGRP3 GRB10	2.08e-04	194	67	4	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ADCY4 RASGRP3 DGKH	2.08e-04	194	67	4	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	2.08e-04	194	67	4	de9c7c602d886d0cd8bbd1d7e7744f84df951238
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC24A4 AP1S2 MARCHF1 LILRB1	2.08e-04	194	67	4	49441ca0a8fa34cb847fecbb4b809dd01d879ebb
Drug	Ethotoin [86-35-1]; Up 200; 19.6uM; MCF7; HT_HG-U133A	HNF1B AP1S1 CALCR SLC34A1 POPDC3 MLXIP KLK13	1.49e-06	194	66	7	4366_UP
Drug	Dihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	CACNA1A HNF1B AP1S1 JADE2 ZNF277 PTPN21	1.98e-05	192	66	6	4152_DN
Drug	6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A	AP1S1 ARFGEF2 CAMTA2 SMG5 PTPN21 WDR59	2.23e-05	196	66	6	6813_DN
Drug	Droperidol [548-73-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	HNF1B CALCR IQCA1 SFI1 PTPN21 WDR59	2.29e-05	197	66	6	2645_UP
Drug	Nabumetone [42924-53-8]; Up 200; 17.6uM; MCF7; HT_HG-U133A	HNF1B CALCR IQCA1 ZNF277 BRINP1 SFI1	2.36e-05	198	66	6	6487_UP
Drug	Gallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A	HNF1B ZNF277 BRINP1 PFKFB2 PTPN21 IL1R1	2.50e-05	200	66	6	5735_UP
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1B	1.48e-05	3	66	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1B	2.95e-05	4	66	2	DOID:6364 (implicated_via_orthology)
Disease	nephrolithiasis	SLC34A1 DGKH WDR72	5.56e-05	33	66	3	EFO_0004253
Disease	Amelogenesis imperfecta type 2	SLC24A4 WDR72	7.35e-05	6	66	2	cv:C0399372
Disease	Osteoporosis	CALCR SLC34A1	7.35e-05	6	66	2	cv:C0029456
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1B	1.03e-04	7	66	2	DOID:0050951 (implicated_via_orthology)
Disease	autoantibody measurement	DGKH DCAF5	1.03e-04	7	66	2	EFO_0004866
Disease	Amelogenesis Imperfecta hypomaturation type	SLC24A4 WDR72	1.37e-04	8	66	2	C0399372
Disease	kallikrein-11 measurement	KLK8 KLK13	1.76e-04	9	66	2	EFO_0010573
Disease	Hypercalcemia	CALCR SLC34A1	3.78e-04	13	66	2	C0020437
Disease	Milk-Alkali Syndrome	CALCR SLC34A1	3.78e-04	13	66	2	C0026141
Disease	urolithiasis	SLC34A1 DGKH WDR72	3.86e-04	63	66	3	MONDO_0024647
Disease	blood urea nitrogen measurement	HNF1B SLC34A1 GRB10 DGKH MLXIP WDR72	5.23e-04	452	66	6	EFO_0004741
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	VANGL2 FCRLB	6.56e-04	17	66	2	EFO_0021969
Disease	Amelogenesis imperfecta	SLC24A4 WDR72	6.56e-04	17	66	2	cv:C0002452
Disease	citrate measurement	SLC34A1 FBXO39 PFKFB2	7.49e-04	79	66	3	EFO_0010114
Disease	FEV change measurement, response to zileuton	GRB10 LMBRD1	1.43e-03	25	66	2	EFO_0005921, EFO_0007676
Disease	Bone Diseases, Developmental	SLC34A1 TMCO1	1.67e-03	27	66	2	C0005941
Disease	corpus callosum mid-anterior volume measurement	GRB10 WDR72	1.67e-03	27	66	2	EFO_0010297
Disease	body weight	CACNA1B HNF1B CALCR SLC24A4 JADE2 GRB10 DGKH BRINP1 WDR59	1.91e-03	1261	66	9	EFO_0004338
Disease	chronic kidney disease	SLC24A4 SLC34A1 MARCHF1 WDR72	1.92e-03	235	66	4	EFO_0003884

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSIQRVAVWILEKYY	VANGL2	266	Q9ULK5
LLRIFKVTKYWASLR	CACNA1A	586	O00555
KTYVSKKLTRYLNWI	PFKFB2	51	O60825
KLTLWYYSEERKLVS	ESYT1	976	Q9BSJ8
SYTWLCYEVKIKRGR	APOBEC3D	31	Q96AK3
SYTWLCYEVKIKRGR	APOBEC3B	31	Q9UH17
TTRYKIYREFARWKV	BRINP1	66	O60477
AVFTEKQRLRWYYLL	CALCR	251	P30988
RKFFLRIGVVYKIWI	ARFGEF2	1756	Q9Y6D5
EWRDLKVVYKRYASL	AP1S1	51	P61966
AVIQRCYRKYKQLTW	CAMTA2	1076	O94983
EYYCRLDFLWKKKLR	ADCY4	811	Q8NFM4
FYVWKRVFQRYAILK	ALG10B	356	Q5I7T1
RLLRIFKVTKYWSSL	CACNA1B	581	Q00975
DYASRYVLWKQIIER	IQCA1	706	Q86XH1
IRMIIAVTSYKRYLW	ASPM	1381	Q8IZT6
KYVYVGLKDRSILVW	NWD1	1446	Q149M9
WRLDRKLGVYVLVLY	SLC24A4	581	Q8NFF2
VSRYVLWIRETIRKY	KLK13	251	Q9UKR3
CSFLEWRDLKIVYKR	AP1S2	46	P56377
WRDLKIVYKRYASLY	AP1S2	51	P56377
LLLEYWKRKSATLAY	ANO7	436	Q6IWH7
LEYFVRYLKLLQKDW	LINS1	521	Q8NG48
LAFCWIYVRKYQSRR	LMBRD1	26	Q9NUN5
YAYTKRAWRKEVLEL	DOP1B	1961	Q9Y3R5
EALVDFIYQYWKLKR	JADE2	421	Q9NQC1
WDLLYKLRFVLTYIA	PCNX3	1236	Q9H6A9
LIISCRKLFYFKIWA	FBXO39	361	Q8N4B4
LRWLQLYIYKDREVT	HAO1	126	Q9UJM8
VERKIYKAYKWLRYS	DCAF5	656	Q96JK2
VYVQLWKRLKAYNRV	MARCHF8	221	Q5T0T0
RWKKRYFKLRGRTLY	DGKH	81	Q86XP1
YVQCKVYVQLWRRLK	MARCHF1	216	Q8TCQ1
KYIWRLCVARHKFYR	PTPN21	291	Q16825
KKRLWEKRYYCHSEV	PIK3C2B	836	O00750
KRTAKYRWFAVLYLL	SLC34A1	506	Q06495
TRAIIKCYWKSYLVL	ABCC4	81	O15439
EIVIREYHKWRTYFK	MLXIP	216	Q9HAP2
YVKRTWYRKFVGVVL	FNDC1	1786	Q4ZHG4
VYTNICRYLDWIKKI	KLK8	241	O60259
SWKKLYVCLRRSGLY	GRB10	306	Q13322
LWVLIAYILYRKKIF	HGSNAT	646	Q68CP4
VLRCRGWYDKVVYKL	FCRLB	121	Q6BAA4
GLWYCYLQVKKVRLR	C1orf220	6	Q5T0J3
LWIRYSQYLDRQLKV	SART3	346	Q15020
YKIFKIDIVLWYRDS	IL1R1	356	P14778
DCRYVSWRRKKLYLL	POPDC3	206	Q9HBV1
ILCYRKREWIKETFY	LIFR	856	P42702
RWSRISRAKKLYKIY	RGS13	76	O14921
KTQKRAALYTWYVRK	HNF1B	161	P35680
AALYTWYVRKQREIL	HNF1B	166	P35680
CIELWLQYTQKRRYK	SFI1	456	A8K8P3
ITWVLVYRTDKYKRL	TMCO1	76	Q9UM00
LLWRKVYYEVIQLIK	SMG5	81	Q9UPR3
QEYRLYREKKTALWI	LILRB1	56	Q8NHL6
RLKICYFMRYWILKF	RASGRP3	71	Q8IV61
FKWLKYIVYKERVSA	ST3GAL3	236	Q11203
KLVKEEVFWRNYFYR	SYAP1	191	Q96A49
ISKYRVRIRSKKWYS	PGBD1	746	Q96JS3
VRIRSKKWYSILVSY	PGBD1	751	Q96JS3
VYTRVTKYRDWIASK	TMPRSS11F	421	Q6ZWK6
RTPRLVYKWFLLIYK	RNF175	131	Q8N4F7
RLLLVVFSKCWKVYD	WDR72	226	Q3MJ13
VEKIIRTRIYESKYW	PRPF38A	21	Q8NAV1
RTRIYESKYWKEECF	PRPF38A	26	Q8NAV1
TPRLVYKWFLLIYKI	RNF121	131	Q9H920
VDTYIYIWDIKDTRK	WDR59	126	Q6PJI9
IFTYERKWYSRKDLA	ZNF598	156	Q86UK7
KLVADFQRYILYWRK	ZNF277	91	Q9NRM2
YSTIDWNKLYRREIK	RPS6KA1	321	Q15418
VFEKTRWIIEKYRLS	MYSM1	741	Q5VVJ2