Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	ooplasm	PRKCA FAF1	1.13e-04	6	58	2	GO:1990917
Domain	PP2A_B56	PPP2R5B PPP2R5E	8.47e-05	5	55	2	IPR002554
Domain	B56	PPP2R5B PPP2R5E	8.47e-05	5	55	2	PF01603
Domain	PNT	ETS1 ETV6	4.60e-04	11	55	2	PS51433
Domain	Pointed_dom	ETS1 ETV6	4.60e-04	11	55	2	IPR003118
Domain	SAM_PNT	ETS1 ETV6	4.60e-04	11	55	2	PF02198
Domain	SAM_PNT	ETS1 ETV6	4.60e-04	11	55	2	SM00251
Pubmed	Protein kinase Calpha regulates Ets1 transcriptional activity in invasive breast cancer cells.	ETS1 PRKCA	2.73e-06	2	58	2	12632071
Pubmed	B56beta, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching.	PPP2R5B PPP2R5E	2.73e-06	2	58	2	18385213
Pubmed	Ets1 is an effector of protein kinase Calpha in cancer cells.	ETS1 PRKCA	2.73e-06	2	58	2	15531915
Pubmed	The double face of the histone variant H3.3.	H3Y2 H3Y1	2.73e-06	2	58	2	21263457
Pubmed	Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.	H3Y2 H3Y1	2.73e-06	2	58	2	20819935
Pubmed	The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells.	ETS1 ETV6	8.19e-06	3	58	2	19829305
Pubmed	DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression.	H3Y2 H3Y1	8.19e-06	3	58	2	31722199
Pubmed	The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.	ETS1 ETV6	1.64e-05	4	58	2	22615925
Pubmed	The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.	PPP2R5B PPP2R5E	2.72e-05	5	58	2	8694763
Pubmed	Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.	PPP2R5B PPP2R5E	2.72e-05	5	58	2	8812429
Pubmed	Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice.	PPP2R5B PPP2R5E	2.72e-05	5	58	2	15095873
Pubmed	The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.	PPP2R5B PPP2R5E	5.71e-05	7	58	2	8703017
Pubmed	Identification of a new family of protein phosphatase 2A regulatory subunits.	PPP2R5B PPP2R5E	5.71e-05	7	58	2	7592815
Pubmed	Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits.	PPP2R5B PPP2R5E	5.71e-05	7	58	2	35415460
Pubmed	Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression.	PPP2R5B PPP2R5E	9.77e-05	9	58	2	23345399
Pubmed	De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.	PPP2R5B PPP2R5E	9.77e-05	9	58	2	30595372
Pubmed	A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.	H3Y2 H3Y1	1.49e-04	11	58	2	25362550
Pubmed	Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.	PPP2R5B PPP2R5E	1.78e-04	12	58	2	15380617
Pubmed	Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.	PPP2R5B PPP2R5E	1.78e-04	12	58	2	16541024
Pubmed	Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.	ETS1 ETV6	2.11e-04	13	58	2	25802403
Pubmed	PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.	PPP2R5B PPP2R5E	2.11e-04	13	58	2	21072166
Pubmed	Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.	PPP2R5B PPP2R5E	2.46e-04	14	58	2	9013886
Pubmed	Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.	PPP2R5B PPP2R5E	2.46e-04	14	58	2	9400615
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP2R5B PPP2R5E	2.46e-04	14	58	2	16048649
Pubmed	Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.	ETS1 ETV6	2.46e-04	14	58	2	14635793
Pubmed	Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation.	ETS1 ETV6	3.23e-04	16	58	2	24727028
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP2R5B PPP2R5E	3.66e-04	17	58	2	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP2R5B PPP2R5E	3.66e-04	17	58	2	21351466
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	DNAJA3 THBS3 FOXRED2 AGO2 GAA	3.87e-04	371	58	5	15747579
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	STK11 CLK3 MINK1 PRKCA PRKG2	3.92e-04	372	58	5	22939624
Pubmed	Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.	PPP2R5B PPP2R5E	4.11e-04	18	58	2	23287597
Pubmed	Shugoshin collaborates with protein phosphatase 2A to protect cohesin.	PPP2R5B PPP2R5E	4.59e-04	19	58	2	16541025
Pubmed	Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.	ADAM18 PRKG2	5.09e-04	20	58	2	22174851
Pubmed	Sidekick 2 directs formation of a retinal circuit that detects differential motion.	KCNG4 PRKCA	6.76e-04	23	58	2	26287463
Pubmed	Type II cadherins guide assembly of a direction-selective retinal circuit.	KCNG4 PRKCA	7.37e-04	24	58	2	25126785
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	ETS1 ETV6	7.37e-04	24	58	2	22056786
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	DNAJA3 STK11 AGO2 CLK3 MINK1 PRKCA FKBP11	7.73e-04	910	58	7	36736316
Pubmed	HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.	PPP2R5B PPP2R5E	8.66e-04	26	58	2	11531413
Pubmed	ETS-family genes in pancreatic development.	ETS1 ETV6	1.08e-03	29	58	2	17907201
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	ETS1 ETV6	1.08e-03	29	58	2	26097038
Pubmed	Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.	PRKCA RAD21	1.31e-03	32	58	2	20056645
Pubmed	HIV gp120 induced gene expression signatures in vaginal epithelial cells.	CAPN14 PRKCA	1.57e-03	35	58	2	23867815
Cytoband	8q24	AGO2 RAD21	5.81e-04	28	58	2	8q24
Cytoband	5p15.1	H3Y2 H3Y1	8.08e-04	33	58	2	5p15.1
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R5B PPP2R5E	5.43e-04	15	42	2	696
GeneFamily	ETS transcription factor family	ETS1 ETV6	1.92e-03	28	42	2	534
Drug	thioridazine hydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	DNAJA3 STK11 RNF123 PRKCA PPIL2 GAA	8.15e-06	198	55	6	6189_DN
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; HL60; HG-U133A	RNF123 HPS1 ETV6 PRKCA PPIL2 FAF1	8.39e-06	199	55	6	2045_DN
Disease	Myeloid Leukemia	AGO2 RAD21	5.12e-04	18	55	2	C0023470
Disease	Leukemia, Monocytic, Chronic	AGO2 RAD21	5.12e-04	18	55	2	C0023466
Disease	HIV-1 infection, Susceptibility to viral and mycobacterial infections	ADAM18 PRKG2	7.00e-04	21	55	2	EFO_0000180, Orphanet_391311
Disease	Adenocarcinoma of large intestine	PRKCA PRKG2 RAD21	7.74e-04	96	55	3	C1319315
Disease	Left Ventricular Hypertrophy	STK11 GAA	9.96e-04	25	55	2	C0149721
Disease	PR interval	STK11 MINK1 PRKCA PPIL2 FAF1	2.27e-03	495	55	5	EFO_0004462
Disease	platelet component distribution width	CAPN14 SCN11A PLEKHG3 SYT5 TNXB GAA	2.75e-03	755	55	6	EFO_0007984
Disease	Primary Ciliary Dyskinesia	ODAD4 IFT122	3.49e-03	47	55	2	C4551720

Protein segments in the cluster

Peptide	Gene	Start	Entry
EYLKTILHRVYGKFL	PPP2R5B	211	Q15173
RDYLKTVLHRIYGKF	PPP2R5E	196	Q16537
LYLRYRPKVKFLFGI	ACER3	241	Q9NUN7
YRDRVIHLLALKAYK	ELL2	206	O00472
GFVLYLYKHRRRPKV	CSMD2	3426	Q7Z408
GLKYHYLIRLTKIAP	AFM	426	P43652
KGPLREYYSRLIHQK	ALG1L2	106	C9J202
IAYLLVYRKHPKYVG	ADAM18	271	Q9Y3Q7
RYKPGTLALREIRKY	H3Y2	41	P0DPK5
IHRTRKQKYFYKGGL	CLK3	546	P49761
TLYAAKKYIVPHLAR	BTBD3	196	Q9Y2F9
AKIILIHTLAKRFYY	ERMP1	501	Q7Z2K6
YFKDRHKLVLRYPHL	AGO2	311	Q9UKV8
CRKRKPLLAIGFYLY	CAPN14	411	A8MX76
LRYQFVKKKGYVRLH	PPIL2	271	Q13356
LGVVRIYHRKAKYLL	RAD21	61	O60216
ALLVRILHKSKLRYY	RADX	236	Q6NSI4
RALRHYYKLNIIRKE	ETV6	396	P41212
RHAYDKLRGLYIPAR	IFT122	1016	Q9HBG6
IKGLYYRRVRKVGAL	KCNG4	36	Q8TDN1
IYFKYHKNLPRARAI	MCF2L2	711	Q86YR7
VLTRPRFKYYLNKLH	FAM135A	1336	Q9P2D6
IIHKTAGKRYVYRFV	ETS1	401	P14921
RYKPGTLALREIRKY	H3Y1	41	P0DPK2
YIHILGRRKLYHVVK	PADI2	226	Q9Y2J8
RYPRHRKLISINKRY	FOXRED2	71	Q8IWF2
YLHRLGIIYRDLKPE	PRKG2	566	Q13237
LIGYHLYRKANRPKV	FKBP11	171	Q9NYL4
GRAPILYYVVKHRKV	BOC	501	Q9BWV1
LGPYARVKRVYRLAK	DEGS2	306	Q6QHC5
YVHKRYPGLVKVVRN	GALNT17	206	Q6IS24
RKALTLRYALLPHLY	GAA	696	P10253
YVKARDRKLLAIYLH	FAF1	366	Q9UNN5
RRKLYVLKYLFEVHF	HPS1	106	Q92902
YGDHYIHIKIRVPKR	DNAJA3	401	Q96EY1
CGHYRVVKYERIKFL	MINK1	1116	Q8N4C8
RYVAICKPLHYKRIL	OR52I1	126	Q8NGK6
GRIGSHIYVYERKLK	PIGB	531	Q92521
YLLPDKRRRYETKVH	SYT5	151	O00445
VRHYKVKREGPKYVI	STAP2	201	Q9UGK3
VIKKYLIGPYYRKLH	TMCO3	476	Q6UWJ1
FRKKRSEYYLIHVLG	TAS2R3	171	Q9NYW6
LFFLHKRGIIYRDLK	PRKCA	451	P17252
IYRGIHSYLRYLKPK	RNF113B	146	Q8IZP6
GSYLLKPVQRILKYH	PLEKHG3	221	A1L390
LVFYHRGYKLRPDRE	ODAD4	101	Q96NG3
YQPRRKRAKLIGKYL	STK11	36	Q15831
IPQIYVHRLIKGEKY	OXCT1	261	P55809
HVYYRRGLALKKIIP	RPF1	171	Q9H9Y2
VQRYRYFRKHGRKPG	SCAF1	1271	Q9H7N4
YRYTRLPHLLKTKLE	RNF123	981	Q5XPI4
KYRFLLYGLLGKKRH	TNXB	1736	P22105
LLHRPQVGYIRVKLY	THBS3	881	P49746
RKILKYPLLHTQYGR	ZNF677	241	Q86XU0
RKLRLHKYYPVFKQL	ZCCHC14	306	Q8WYQ9
LKIIALDPYHYFRRG	SCN11A	626	Q9UI33
GKKYHADLYVRRIPL	AGPAT4	246	Q9NRZ5
HILRRPIIVYGVKYY	ZRANB1	531	Q9UGI0