Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	failure of neuromuscular synapse postsynaptic differentiation	UTP14C UTP14A	3.21e-05	6	21	2	MP:0001055
MousePheno	impaired fibroblast cell migration	MTSS1 TGS1	7.69e-05	9	21	2	MP:0011707
MousePheno	abnormal liver development	MBTD1 MED1 PKD2	8.55e-05	58	21	3	MP:0000596
MousePheno	abnormal placenta vasculature	MLLT10 MED1 VPS4B PKD2	1.72e-04	192	21	4	MP:0003231
MousePheno	abnormal hepatobiliary system development	MBTD1 MED1 PKD2	1.77e-04	74	21	3	MP:0003943
MousePheno	increased kidney cell proliferation	MTSS1 PKD2	2.88e-04	17	21	2	MP:0011440
Domain	SSU_processome_Utp14	UTP14C UTP14A	2.01e-06	2	27	2	IPR006709
Domain	Utp14	UTP14C UTP14A	2.01e-06	2	27	2	PF04615
Domain	MBT	MBTD1 PHF20L1	8.99e-05	10	27	2	PF02820
Domain	Mbt	MBTD1 PHF20L1	8.99e-05	10	27	2	IPR004092
Domain	Zinc_finger_PHD-type_CS	MLLT10 PHF20L1	3.96e-03	65	27	2	IPR019786
Domain	ZF_PHD_1	MLLT10 PHF20L1	8.44e-03	96	27	2	PS01359
Domain	PDZ	MPP1 PPP1R9A	1.76e-02	141	27	2	PF00595
Domain	AAA+_ATPase	DYNC2H1 VPS4B	1.83e-02	144	27	2	IPR003593
Domain	AAA	DYNC2H1 VPS4B	1.83e-02	144	27	2	SM00382
Domain	Znf_FYVE_PHD	MLLT10 PHF20L1	1.90e-02	147	27	2	IPR011011
Domain	PDZ	MPP1 PPP1R9A	1.92e-02	148	27	2	SM00228
Domain	-	MPP1 PPP1R9A	1.97e-02	150	27	2	2.30.42.10
Domain	PDZ	MPP1 PPP1R9A	2.00e-02	151	27	2	PS50106
Domain	PDZ	MPP1 PPP1R9A	2.02e-02	152	27	2	IPR001478
Domain	-	MPP1 DYNC2H1 SMC1A VPS4B	2.13e-02	746	27	4	3.40.50.300
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	MED1 TGS1	3.19e-04	18	21	2	MM15034
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	MED1 TGS1	3.19e-04	18	21	2	M26942
Pathway	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION	MED1 TGS1	7.25e-04	27	21	2	M26943
Pathway	REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE	MED1 DYNC2H1 TGS1 PKD2	8.71e-04	297	21	4	M27050
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_TERMINATION	POLR1F TTF1	9.58e-04	31	21	2	MM15427
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_TERMINATION	POLR1F TTF1	9.58e-04	31	21	2	M496
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	MED1 TGS1	1.76e-03	42	21	2	M27172
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION	POLR1F TTF1	2.19e-03	47	21	2	MM15428
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION	POLR1F TTF1	2.19e-03	47	21	2	M1095
Pathway	REACTOME_HEME_SIGNALING	MED1 TGS1	2.38e-03	49	21	2	M41832
Pathway	REACTOME_CYTOPROTECTION_BY_HMOX1	MED1 TGS1	2.68e-03	52	21	2	MM15684
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	MED1 TGS1	2.99e-03	55	21	2	M27145
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	MED1 TGS1	2.99e-03	55	21	2	M27001
Pathway	REACTOME_RRNA_PROCESSING	RPL10A UTP14C UTP14A	3.32e-03	205	21	3	M27685
Pathway	REACTOME_RRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL	UTP14C UTP14A	3.55e-03	60	21	2	M27613
Pathway	REACTOME_CYTOPROTECTION_BY_HMOX1	MED1 TGS1	3.55e-03	60	21	2	M41830
Pathway	REACTOME_METABOLISM_OF_RNA	RPL10A TRMT6 UTP14C TGS1 UTP14A	3.61e-03	724	21	5	M16843
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RPL10A POLR1F ZCCHC9 MED1 COIL TTF1 SMC1A UTP14A	1.05e-07	759	28	8	35915203
Pubmed	Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice.	UTP14C UTP14A	6.25e-07	2	28	2	14500567
Pubmed	Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice.	UTP14C UTP14A	6.25e-07	2	28	2	11415997
Pubmed	Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment.	UTP14C UTP14A	6.25e-07	2	28	2	10499552
Pubmed	Testosterone suppresses spermatogenesis in juvenile spermatogonial depletion (jsd ) mice.	UTP14C UTP14A	6.25e-07	2	28	2	11466222
Pubmed	Restoration of spermatogenesis and fertility in azoospermic mutant mice by suppression and reelevation of testosterone followed by intracytoplasmic sperm injection.	UTP14C UTP14A	6.25e-07	2	28	2	11751268
Pubmed	Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice.	UTP14C UTP14A	6.25e-07	2	28	2	9354954
Pubmed	shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.	UTP14C UTP14A	6.25e-07	2	28	2	25790000
Pubmed	Defect in germ cells, not in supporting cells, is the cause of male infertility in the jsd mutant mouse: proliferation of spermatogonial stem cells without differentiation.	UTP14C UTP14A	6.25e-07	2	28	2	11168646
Pubmed	Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation.	UTP14C UTP14A	6.25e-07	2	28	2	1346141
Pubmed	Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.	UTP14C UTP14A	6.25e-07	2	28	2	21733828
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	RPL10A POLR1F BBX COIL TTF1 UTP14A	7.83e-07	410	28	6	26949251
Pubmed	Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids.	UTP14C UTP14A	1.87e-06	3	28	2	8529672
Pubmed	Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice.	UTP14C UTP14A	1.87e-06	3	28	2	3401545
Pubmed	Arrest of spermatogonial differentiation in jsd/jsd, Sl17H/Sl17H, and cryptorchid mice.	UTP14C UTP14A	1.87e-06	3	28	2	10456866
Pubmed	Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.	UTP14C UTP14A	1.87e-06	3	28	2	20650881
Pubmed	Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.	UTP14C UTP14A	1.87e-06	3	28	2	17475932
Pubmed	The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b.	UTP14C UTP14A	1.87e-06	3	28	2	15289605
Pubmed	Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.	UTP14C UTP14A	1.87e-06	3	28	2	17291484
Pubmed	Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations.	UTP14C UTP14A	1.87e-06	3	28	2	16627582
Pubmed	An X-to-autosome retrogene is required for spermatogenesis in mice.	UTP14C UTP14A	1.87e-06	3	28	2	15258580
Pubmed	FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells.	MED1 SMC1A	1.87e-06	3	28	2	27739523
Pubmed	Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.	UTP14C UTP14A	1.87e-06	3	28	2	30910870
Pubmed	Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice.	UTP14C UTP14A	1.87e-06	3	28	2	19136388
Pubmed	Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells.	UTP14C UTP14A	3.75e-06	4	28	2	7924983
Pubmed	Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway.	UTP14C UTP14A	3.75e-06	4	28	2	11900972
Pubmed	UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man.	UTP14C UTP14A	3.75e-06	4	28	2	16354793
Pubmed	Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis.	MED1 TGS1	3.75e-06	4	28	2	12754253
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL10A MBTD1 BBX MED1 LEO1 COIL TTF1 SMC1A	5.74e-06	1294	28	8	30804502
Pubmed	Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.	MED1 TGS1	6.24e-06	5	28	2	11912212
Pubmed	Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice.	UTP14C UTP14A	6.24e-06	5	28	2	2767687
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MCC BBX MED1 LEO1 DYNC2H1 SMC1A RASAL2 PKD2	6.68e-06	1321	28	8	27173435
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZCCHC9 TRMT6 BBX MED1 PHF20L1 SMC1A	7.56e-06	608	28	6	36089195
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RPL10A POLR1F BBX MED1 COIL SMC1A UTP14A	8.18e-06	954	28	7	36373674
Pubmed	Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.	MTSS1 PKD2	9.36e-06	6	28	2	20181743
Pubmed	p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.	UTP14C UTP14A	9.36e-06	6	28	2	18356279
Pubmed	Identification of a novel Sry-related gene and its germ cell-specific expression.	UTP14C UTP14A	9.36e-06	6	28	2	10359848
Pubmed	Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway.	UTP14C UTP14A	9.36e-06	6	28	2	15938716
Pubmed	Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription.	UTP14C UTP14A	9.36e-06	6	28	2	11733032
Pubmed	Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.	COIL TGS1	9.36e-06	6	28	2	16687569
Pubmed	Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.	BBX PHF20L1 TTF1	1.26e-05	56	28	3	26919559
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	RPL10A POLR1F ZCCHC9 MED1 VPS4B UTP14A	2.02e-05	723	28	6	34133714
Pubmed	Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.	MED1 TGS1	4.10e-05	12	28	2	12189208
Pubmed	Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes.	UTP14C UTP14A	4.85e-05	13	28	2	11700028
Pubmed	An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs.	UTP14C UTP14A	4.85e-05	13	28	2	2216762
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MBTD1 BBX PHF20L1 TTF1 SMC1A UTP14A	5.21e-05	857	28	6	25609649
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RPL10A MPP1 POLR1F COIL TTF1 SMC1A UTP14A	6.50e-05	1318	28	7	30463901
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BBX MED1 COIL UTP14A	7.53e-05	283	28	4	30585729
Pubmed	Mouse models of male infertility.	UTP14C UTP14A	8.44e-05	17	28	2	12360237
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	MED1 TGS1	8.44e-05	17	28	2	28291835
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	BBX UTP14C UTP14A	9.27e-05	109	28	3	33554859
Pubmed	Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.	MED1 TGS1	1.06e-04	19	28	2	22982455
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RPL10A TRMT6 COIL DYNC2H1 SMC1A RASAL2 UTP14A	1.06e-04	1425	28	7	30948266
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	RPL10A LEO1 COIL SMC1A UTP14A	1.11e-04	605	28	5	28977666
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYLC2 BBX LEO1 PHF20L1 PPP1R9A UTP14C UTP14A	1.14e-04	1442	28	7	35575683
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	POLR1F ZCCHC9 BBX MED1 TTF1 PPP1R9A UTP14A	1.44e-04	1497	28	7	31527615
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	RPL10A COIL SMC1A UTP14A	1.53e-04	340	28	4	29478914
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	MBTD1 MED1 UTP14A	1.71e-04	134	28	3	25452129
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RPL10A BBX MED1 COIL SMC1A UTP14A	1.87e-04	1082	28	6	38697112
Pubmed	Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.	MED1 SMC1A	2.01e-04	26	28	2	28087629
Pubmed	MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.	UTP14C UTP14A	2.01e-04	26	28	2	35920200
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	MLLT10 COIL UTP14C UTP14A	2.11e-04	370	28	4	22922362
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	RPL10A MPP1 TRMT6 COIL VPS4B	2.24e-04	704	28	5	32994395
Pubmed	Mediator and cohesin connect gene expression and chromatin architecture.	MED1 SMC1A	2.33e-04	28	28	2	20720539
Pubmed	Spermatogonia-dependent expression of testicular genes in mice.	UTP14C UTP14A	2.50e-04	29	28	2	12051830
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	RPL10A MED1 LEO1 COIL SMC1A TGS1	2.64e-04	1153	28	6	29845934
Pubmed	Nucleolar proteome dynamics.	RPL10A ZCCHC9 COIL SMC1A	3.38e-04	419	28	4	15635413
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	BBX COIL RASAL2 IQCE UTP14A	3.52e-04	777	28	5	35844135
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	MBTD1 UTP14C UTP14A	3.87e-04	177	28	3	26206133
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RPL10A TRMT6 COIL SMC1A RASAL2 UTP14A	4.19e-04	1257	28	6	36526897
Pubmed	Directed proteomic analysis of the human nucleolus.	RPL10A COIL SMC1A	6.19e-04	208	28	3	11790298
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DYNC2H1 SMC1A UTP14C UTP14A	6.23e-04	493	28	4	15368895
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	COIL TTF1 UTP14A	6.36e-04	210	28	3	16565220
Interaction	POLR1G interactions	MCC POLR1F BBX LEO1 COIL TTF1 SMC1A UTP14A	1.68e-07	489	27	8	int:POLR1G
Interaction	POLR1E interactions	MCC POLR1F BBX LEO1 COIL TTF1 UTP14A	2.96e-07	350	27	7	int:POLR1E
Interaction	MCC interactions	CYLC2 MCC BBX RASAL2 IQCE UTP14C	3.38e-07	215	27	6	int:MCC
Interaction	NIFK interactions	RPL10A ZCCHC9 BBX LEO1 COIL TTF1 UTP14A	1.20e-06	431	27	7	int:NIFK
Interaction	ANKS1B interactions	MCC COIL RASAL2	1.25e-05	34	27	3	int:ANKS1B
Interaction	GPATCH4 interactions	RPL10A ZCCHC9 BBX COIL TTF1	1.27e-05	232	27	5	int:GPATCH4
Interaction	MKI67 interactions	RPL10A POLR1F BBX COIL TTF1 SMC1A UTP14A	1.74e-05	648	27	7	int:MKI67
Interaction	RPL31 interactions	RPL10A BBX LEO1 COIL TTF1 VPS4B UTP14A	2.38e-05	680	27	7	int:RPL31
Interaction	HECTD1 interactions	RPL10A POLR1F ZCCHC9 MED1 COIL TTF1 SMC1A UTP14A	3.04e-05	984	27	8	int:HECTD1
Interaction	UTP14C interactions	MCC UTP14C UTP14A	4.03e-05	50	27	3	int:UTP14C
Interaction	TGS1 interactions	MED1 COIL TGS1	1.36e-04	75	27	3	int:TGS1
Interaction	NUP43 interactions	BBX LEO1 PHF20L1 COIL TTF1 SMC1A	1.47e-04	625	27	6	int:NUP43
Interaction	NFKBIB interactions	MCC RASAL2 TGS1	2.04e-04	86	27	3	int:NFKBIB
Interaction	ANKRD28 interactions	LEO1 SMC1A PPP1R9A TGS1	2.56e-04	235	27	4	int:ANKRD28
Interaction	SMC5 interactions	RPL10A POLR1F BBX MED1 COIL SMC1A UTP14A	2.69e-04	1000	27	7	int:SMC5
Interaction	ZNF330 interactions	TRMT6 BBX LEO1 COIL UTP14A	2.80e-04	446	27	5	int:ZNF330
Interaction	GCC1 interactions	COIL SMC1A UTP14C	3.09e-04	99	27	3	int:GCC1
Interaction	FGFBP1 interactions	ZCCHC9 BBX TTF1 UTP14A	3.60e-04	257	27	4	int:FGFBP1
Interaction	CEP70 interactions	COIL IQCE UTP14C UTP14A	3.87e-04	262	27	4	int:CEP70
Interaction	RBM4B interactions	RPL10A COIL TTF1 UTP14A	3.87e-04	262	27	4	int:RBM4B
Interaction	SOX2 interactions	RPL10A ZCCHC9 MED1 LEO1 PHF20L1 SMC1A IQCE UTP14A	3.98e-04	1422	27	8	int:SOX2
Interaction	BBX interactions	MCC BBX COIL	3.99e-04	108	27	3	int:BBX
Interaction	HMGB1 interactions	RPL10A CYLC2 COIL RASAL2 UTP14C	4.16e-04	486	27	5	int:HMGB1
Interaction	ADARB1 interactions	RPL10A BBX MED1 TTF1 SMC1A	4.28e-04	489	27	5	int:ADARB1
Interaction	RSRC1 interactions	SMC1A TGS1 UTP14A	4.43e-04	112	27	3	int:RSRC1
Interaction	BRD3 interactions	BBX MLLT10 MED1 COIL UTP14A	4.48e-04	494	27	5	int:BRD3
Interaction	H3C3 interactions	ZCCHC9 TRMT6 BBX MED1 SMC1A	4.52e-04	495	27	5	int:H3C3
Interaction	CIT interactions	RPL10A MED1 COIL DYNC2H1 SMC1A RASAL2 UTP14C UTP14A	4.54e-04	1450	27	8	int:CIT
GeneFamily	PHD finger proteins	MLLT10 PHF20L1	3.17e-03	90	17	2	88
GeneFamily	PDZ domain containing	MPP1 PPP1R9A	8.79e-03	152	17	2	1220
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ZCCHC9 PPP1R9A	1.23e-02	181	17	2	694
GeneFamily	EF-hand domain containing	MCC PKD2	1.76e-02	219	17	2	863
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	BBX MLLT10 LEO1 PHF20L1 UTP14C UTP14A	4.55e-05	532	27	6	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	DYNC2H1 SMC1A TGS1 UTP14A	9.66e-05	192	27	4	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlas	facebase_RNAseq_e8.5_FloorPlate_2500_K3	RPL10A POLR1F TRMT6 BBX MLLT10 LEO1 COIL TGS1	2.17e-04	1371	27	8	facebase_RNAseq_e8.5_FloorPlate_2500_K3
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#1_top-relative-expression-ranked_1000	BBX PHF20L1 SMC1A RASAL2	3.13e-04	261	27	4	gudmap_developingGonad_e12.5_epididymis_k1_1000
CoexpressionAtlas	dev gonad_e11.5_F_ReproVasc_Flk_k-means-cluster#2_top-relative-expression-ranked_500	RASAL2 MTSS1	3.22e-04	21	27	2	gudmap_dev gonad_e11.5_F_ReproVasc_Flk_k2_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	DYNC2H1 SMC1A RASAL2 TGS1 UTP14A	3.66e-04	498	27	5	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000	BBX PHF20L1 SMC1A RASAL2 TGS1 PKD2	4.38e-04	806	27	6	gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlas	facebase_RNAseq_e8.5_NeuroEpith_hindBrain_2500_K1	POLR1F TRMT6 LEO1 COIL DYNC2H1 TGS1 UTP14A	4.92e-04	1164	27	7	facebase_RNAseq_e8.5_NeuroEpith_hindBrain_2500_K1
Drug	Suloctidil [54063-56-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A	POLR1F MLLT10 DYNC2H1 IQCE TGS1	3.03e-06	195	27	5	5021_DN
Drug	Clindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; PC3; HT_HG-U133A	MCC MBTD1 SMC1A PPP1R9A IQCE	3.27e-06	198	27	5	2057_UP
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	BBX MLLT10 MED1 PPP1R9A	7.24e-05	191	27	4	4279_DN
Drug	Monobenzone [103-16-2]; Down 200; 20uM; HL60; HT_HG-U133A	MBTD1 SMC1A RASAL2 MTSS1	7.39e-05	192	27	4	3054_DN
Drug	PHA-00846566E [724718-26-7]; Up 200; 10uM; PC3; HT_HG-U133A	MBTD1 MED1 TTF1 SMC1A	7.69e-05	194	27	4	7086_UP
Drug	Pergolide mesylate [66104-23-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	BBX PHF20L1 DYNC2H1 SMC1A	7.85e-05	195	27	4	7434_UP
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; MCF7; HT_HG-U133A	MBTD1 PHF20L1 RASAL2 IQCE	7.85e-05	195	27	4	1505_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A	POLR1F SMC1A RASAL2 IQCE	7.85e-05	195	27	4	7377_UP
Drug	Salsolinol hydrobromide [38221-21-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	MCC POLR1F SMC1A RASAL2	7.85e-05	195	27	4	2791_DN
Drug	radicicol; Down 200; 0.1uM; MCF7; HT_HG-U133A	MBTD1 MLLT10 SMC1A RASAL2	8.00e-05	196	27	4	5947_DN
Drug	Loperamide hydrochloride [34552-83-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	POLR1F SMC1A TGS1 UTP14A	8.00e-05	196	27	4	5267_DN
Drug	Clioquinol [130-26-7]; Down 200; 13uM; PC3; HT_HG-U133A	MLLT10 SMC1A IQCE TGS1	8.00e-05	196	27	4	4663_DN
Drug	Chlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; PC3; HT_HG-U133A	MBTD1 MLLT10 MED1 TGS1	8.00e-05	196	27	4	6692_DN
Drug	Phenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; HL60; HT_HG-U133A	POLR1F MBTD1 MLLT10 SMC1A	8.00e-05	196	27	4	2537_DN
Drug	Dichlorphenamide [120-97-8]; Down 200; 13.2uM; HL60; HT_HG-U133A	SMC1A RASAL2 MTSS1 UTP14A	8.16e-05	197	27	4	3027_DN
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; PC3; HT_HG-U133A	MCC MBTD1 MLLT10 IQCE	8.16e-05	197	27	4	6620_DN
Drug	pioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A	MLLT10 SMC1A RASAL2 MTSS1	8.16e-05	197	27	4	5972_UP
Drug	Succinylsulfathiazole [116-43-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	MCC POLR1F MLLT10 RASAL2	8.16e-05	197	27	4	4265_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A	PHF20L1 SMC1A PPP1R9A TGS1	8.16e-05	197	27	4	6050_DN
Drug	Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A	MBTD1 MLLT10 SMC1A RASAL2	8.16e-05	197	27	4	7177_UP
Drug	estradiol, USP; Up 200; 0.01uM; HL60; HT_HG-U133A	SMC1A RASAL2 MTSS1 UTP14A	8.32e-05	198	27	4	2701_UP
Drug	Mesoridazine besylate [32672-69-8]; Up 200; 7.4uM; PC3; HT_HG-U133A	MBTD1 MLLT10 PPP1R9A IQCE	8.32e-05	198	27	4	7256_UP
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DYNC2H1 RASAL2 IQCE TGS1	8.32e-05	198	27	4	1538_DN
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; HL60; HT_HG-U133A	POLR1F MBTD1 DYNC2H1 SMC1A	8.49e-05	199	27	4	1337_DN
Drug	Benzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	MPP1 POLR1F DYNC2H1 PPP1R9A	8.49e-05	199	27	4	3169_UP
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Down 200; 21uM; MCF7; HT_HG-U133A	MED1 IQCE TGS1 PKD2	8.49e-05	199	27	4	7184_DN
Drug	Phenindione [83-12-5]; Up 200; 18uM; MCF7; HT_HG-U133A	MCC POLR1F RASAL2 MTSS1	8.65e-05	200	27	4	5991_UP
Drug	3-deazacytidine	COIL RASAL2 UTP14C UTP14A	9.70e-05	206	27	4	CID000001652
Drug	pseudouridine	TRMT6 UTP14C UTP14A	1.69e-04	91	27	3	CID000015047
Drug	archaeosine	UTP14C UTP14A	2.54e-04	20	27	2	CID000132841
Drug	glyphosine	DYNC2H1 PKD2	6.57e-04	32	27	2	CID000017112
Drug	Chloroprene	MCC BBX MLLT10 MED1 LEO1 PHF20L1 MTSS1	7.81e-04	1348	27	7	ctd:D002737
Drug	3-methylcrotonyl-CoA	MCC MTSS1	8.32e-04	36	27	2	CID000000099
Drug	AC1L1CRO	UTP14C UTP14A	1.03e-03	40	27	2	CID000002029
Drug	Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	POLR1F RASAL2 UTP14A	1.05e-03	170	27	3	6051_UP
Drug	4-vinyl-1-cyclohexene dioxide	MED1 SMC1A TGS1	1.05e-03	170	27	3	ctd:C012606
Drug	resveratrol; Down 200; 10uM; MCF7; HT_HG-U133A_EA	MLLT10 MED1 IQCE	1.18e-03	177	27	3	841_DN
Drug	U1-6	UTP14C UTP14A	1.30e-03	45	27	2	CID006914648
Drug	Ellipticine [519-23-3]; Up 200; 16.2uM; HL60; HG-U133A	BBX MED1 TTF1	1.32e-03	184	27	3	1765_UP
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A	BBX MED1 SMC1A	1.42e-03	189	27	3	6649_DN
Drug	Phenacetin [62-44-2]; Up 200; 22.4uM; MCF7; HT_HG-U133A	MCC MBTD1 PPP1R9A	1.42e-03	189	27	3	2832_UP
Drug	Nocodazole [31430-18-9]; Down 200; 13.2uM; PC3; HT_HG-U133A	MBTD1 MLLT10 MTSS1	1.44e-03	190	27	3	7145_DN
Drug	Acacetin [480-44-4]; Down 200; 14uM; HL60; HT_HG-U133A	POLR1F MLLT10 DYNC2H1	1.44e-03	190	27	3	2189_DN
Drug	Methotrexate [59-05-2]; Down 200; 8.8uM; PC3; HT_HG-U133A	MED1 SMC1A IQCE	1.44e-03	190	27	3	6318_DN
Drug	Dicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A	MBTD1 MLLT10 IQCE	1.44e-03	190	27	3	1483_UP
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A	BBX MED1 PPP1R9A	1.44e-03	190	27	3	4307_DN
Drug	Carbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	DYNC2H1 SMC1A UTP14A	1.49e-03	192	27	3	4110_DN
Drug	Methimazole [60-56-0]; Up 200; 35uM; MCF7; HT_HG-U133A	MBTD1 RASAL2 IQCE	1.49e-03	192	27	3	3432_UP
Drug	Clomipramine hydrochloride [17321-77-6]; Down 200; 11.4uM; PC3; HT_HG-U133A	MLLT10 SMC1A IQCE	1.49e-03	192	27	3	4487_DN
Drug	2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A	BBX DYNC2H1 MTSS1	1.49e-03	192	27	3	5206_UP
Drug	Hycanthone [3105-97-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	SMC1A RASAL2 UTP14A	1.51e-03	193	27	3	3229_DN
Drug	Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; PC3; HT_HG-U133A	MLLT10 SMC1A TGS1	1.51e-03	193	27	3	6704_DN
Drug	Bisacodyl [603-50-9]; Down 200; 11uM; PC3; HT_HG-U133A	MBTD1 IQCE TGS1	1.51e-03	193	27	3	4616_DN
Drug	2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A	BBX DYNC2H1 MTSS1	1.51e-03	193	27	3	5600_UP
Drug	Triamcinolone [124-94-7]; Up 200; 10.2uM; PC3; HT_HG-U133A	MBTD1 RASAL2 IQCE	1.51e-03	193	27	3	2078_UP
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A	MCC MBTD1 SMC1A	1.51e-03	193	27	3	2852_UP
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A	BBX MED1 UTP14A	1.51e-03	193	27	3	3906_DN
Drug	Procaine hydrochloride [51-05-8]; Down 200; 14.6uM; MCF7; HT_HG-U133A	POLR1F MBTD1 PKD2	1.51e-03	193	27	3	5430_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MBTD1 PHF20L1 IQCE	1.53e-03	194	27	3	3606_DN
Drug	Pimethixene maleate [13187-06-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A	MED1 UTP14A PKD2	1.53e-03	194	27	3	7468_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; HL60; HT_HG-U133A	MLLT10 MTSS1 UTP14A	1.53e-03	194	27	3	3015_DN
Drug	Glimepiride [93479-97-1]; Up 200; 8.2uM; PC3; HT_HG-U133A	MLLT10 RASAL2 UTP14A	1.53e-03	194	27	3	6628_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	MBTD1 DYNC2H1 PPP1R9A	1.53e-03	194	27	3	6589_UP
Drug	Pindolol [13523-86-9]; Down 200; 16.2uM; MCF7; HT_HG-U133A	MCC MBTD1 SMC1A	1.53e-03	194	27	3	2238_DN
Drug	Primaquine diphosphate [63-45-6]; Down 200; 8.8uM; PC3; HT_HG-U133A	POLR1F PPP1R9A IQCE	1.53e-03	194	27	3	4263_DN
Drug	2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A	RASAL2 PPP1R9A MTSS1	1.53e-03	194	27	3	6173_UP
Drug	2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A	BBX MTSS1 UTP14A	1.56e-03	195	27	3	6999_UP
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	POLR1F RASAL2 UTP14A	1.56e-03	195	27	3	3893_DN
Drug	Cyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	MBTD1 RASAL2 IQCE	1.56e-03	195	27	3	1521_DN
Drug	Drofenine hydrochloride [548-66-3]; Up 200; 11.4uM; MCF7; HT_HG-U133A	MED1 RASAL2 PPP1R9A	1.56e-03	195	27	3	3455_UP
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; PC3; HT_HG-U133A	MLLT10 MED1 TGS1	1.56e-03	195	27	3	2071_DN
Drug	Amoxapine [14028-44-5]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MLLT10 PHF20L1 UTP14A	1.56e-03	195	27	3	4996_DN
Drug	Homocysteine	BBX TTF1 IQCE	1.56e-03	195	27	3	ctd:D006710
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	MCC MLLT10 MED1	1.56e-03	195	27	3	1478_DN
Drug	ICI182,780; Up 200; 1uM; PC3; HT_HG-U133A	BBX MED1 PPP1R9A	1.56e-03	195	27	3	6918_UP
Drug	Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A	MBTD1 SMC1A MTSS1	1.56e-03	195	27	3	3710_DN
Drug	Clomiphene citrate (Z,E) [50-41-9]; Down 200; 6.6uM; PC3; HT_HG-U133A	MCC MBTD1 MLLT10	1.56e-03	195	27	3	6648_DN
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	MLLT10 IQCE TGS1	1.56e-03	195	27	3	1652_DN
Drug	PHA-00816795 [212631-79-3]; Up 200; 10uM; PC3; HT_HG-U133A	MBTD1 SMC1A IQCE	1.56e-03	195	27	3	7072_UP
Drug	Gentamicine sulfate [1405-41-0]; Up 200; 2.6uM; MCF7; HT_HG-U133A	MCC MLLT10 RASAL2	1.56e-03	195	27	3	7237_UP
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A	MLLT10 SMC1A UTP14A	1.56e-03	195	27	3	6200_DN
Drug	Antimycin A [1397-94-0]; Down 200; 7.2uM; PC3; HT_HG-U133A	MLLT10 SMC1A MTSS1	1.56e-03	195	27	3	5053_DN
Drug	Capsaicin [404-86-4]; Down 200; 13uM; HL60; HT_HG-U133A	DYNC2H1 SMC1A MTSS1	1.56e-03	195	27	3	3034_DN
Drug	Lisinopril [83915-83-7]; Up 200; 9uM; MCF7; HT_HG-U133A	MBTD1 DYNC2H1 IQCE	1.56e-03	195	27	3	7403_UP
Drug	oxaprozin; Down 200; 300uM; MCF7; HT_HG-U133A_EA	MLLT10 MED1 IQCE	1.56e-03	195	27	3	863_DN
Drug	Methoxamine hydrochloride [61-16-5]; Down 200; 16.2uM; HL60; HT_HG-U133A	MLLT10 DYNC2H1 TGS1	1.58e-03	196	27	3	2488_DN
Drug	Atractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT_HG-U133A	MCC RASAL2 IQCE	1.58e-03	196	27	3	3435_UP
Drug	Flunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; PC3; HT_HG-U133A	MBTD1 MLLT10 PPP1R9A	1.58e-03	196	27	3	7252_UP
Drug	Niacin [59-67-6]; Up 200; 32.4uM; MCF7; HT_HG-U133A	MLLT10 TTF1 DYNC2H1	1.58e-03	196	27	3	5301_UP
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; PC3; HT_HG-U133A	MPP1 IQCE TGS1	1.58e-03	196	27	3	5860_DN
Drug	Rapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A	MED1 RASAL2 UTP14A	1.58e-03	196	27	3	4445_DN
Drug	Betulinic acid [472-15-1]; Down 200; 8.8uM; PC3; HT_HG-U133A	MCC MBTD1 MLLT10	1.58e-03	196	27	3	4101_DN
Drug	Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Down 200; 11.8uM; HL60; HT_HG-U133A	MCC MLLT10 UTP14A	1.58e-03	196	27	3	2158_DN
Drug	Epicatechin-(-) [154-23-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	DYNC2H1 SMC1A UTP14A	1.58e-03	196	27	3	4419_DN
Drug	Methimazole [60-56-0]; Up 200; 35uM; HL60; HT_HG-U133A	MCC MBTD1 DYNC2H1	1.58e-03	196	27	3	2570_UP
Drug	Gemfibrozil [25812-30-0]; Down 200; 16uM; PC3; HT_HG-U133A	POLR1F MLLT10 SMC1A	1.58e-03	196	27	3	5069_DN
Drug	Enoxacin [74011-58-8]; Down 200; 12.4uM; HL60; HG-U133A	MCC MBTD1 MLLT10	1.58e-03	196	27	3	1597_DN
Disease	serum albumin measurement	MCC POLR1F BBX MLLT10	1.69e-03	592	26	4	EFO_0004535
Disease	brain volume measurement	MCC POLR1F MLLT10 PKD2	1.72e-03	595	26	4	EFO_0006930
Disease	small cell lung carcinoma	BBX DYNC2H1	2.26e-03	80	26	2	EFO_0000702
Disease	multisite chronic pain	BBX MLLT10	3.17e-03	95	26	2	EFO_0010100
Disease	Ciliopathies	DYNC2H1 PKD2	4.22e-03	110	26	2	C4277690
Disease	myeloid white cell count	MCC BBX RASAL2 TGS1	8.65e-03	937	26	4	EFO_0007988

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKKKKKKSNHQEFEA	TTF1	276	Q15361
PAYKNKSKKKKKKSN	TTF1	326	Q15361
KKNLFHKIVSKYKHK	BBX	741	Q8WY36
KNAKKDAKKDAKKNA	CYLC2	321	Q14093
LQAQWKVYKHKKKKA	IQCE	526	Q6IPM2
KAEDDDKANKKHKKY	LEO1	641	Q8WVC0
KKKAKSQQYKGHKKM	MBTD1	576	Q05BQ5
HAKEYKKARQEIKKK	MTSS1	126	O43312
KKKEKCEYKKKAKNP	COIL	186	P38432
IYKDVEKKKKKDKNN	RASAL2	231	Q9UJF2
EKYNDKKRKEEKKKN	DYNC2H1	2831	Q8NCM8
YEKAKKKHQNKLKKL	MCC	776	P23508
GKKKKYKDKYLAKHS	MPP1	246	Q00013
EYSTEKHKKHKKEKK	MED1	1491	Q15648
KKKKKKKSKQHDYSD	PHF20L1	571	A8MW92
HSKNLFLKDKKKKNY	PRORSD1P	46	A6NEY8
KYNKEMSKRKHKKKH	NANOGNB	156	Q7Z5D8
KHHEKEKKKYKEKDK	MLLT10	226	P55197
EKKKYKEKDKHKQKH	MLLT10	231	P55197
KLKEYLKNKEKKAQK	VPS4B	71	O75351
YHKVVKKGKAKKALK	UTP14C	251	Q5TAP6
KKSLQNAQKHYKKRK	SMC1A	316	Q14683
KYHKVVKKGKAKKAL	UTP14A	251	Q9BVJ6
GYQSDHKKKKKKRKH	POLR1F	301	Q3B726
KGYHKALVKLKLKKN	PKD2	706	Q13563
NKKLVKKLAKKYDAF	RPL10A	96	P62906
FAQDKYIKKKKKKYE	TRMT6	141	Q9UJA5
AKHKKNKKKKEYLNE	ZCCHC9	56	Q8N567
KVKIKKKKHQKKYLD	TGS1	121	Q96RS0
EKKYNKAKKLIKDFQ	PPP1R9A	761	Q9ULJ8