Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 UFSP2 USP17L12 USP17L20 USP17L24 USP17L5	1.31e-06	137	51	6	GO:0019783
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	6.40e-06	2	51	2	GO:0004572
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 UFSP2 USP17L12 USP17L20 USP17L24 USP17L5	9.19e-06	192	51	6	GO:0008234
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.06e-05	114	51	5	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.59e-05	124	51	5	GO:0101005
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	MAN2A2 MAN2A1	2.84e-04	10	51	2	GO:0015924
GeneOntologyMolecularFunction	transcription coregulator binding	TRERF1 FOXO1 PCLO PAX6	4.48e-04	140	51	4	GO:0001221
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN2A2 MAN2A1	6.57e-04	15	51	2	GO:0004559
GeneOntologyMolecularFunction	mannosidase activity	MAN2A2 MAN2A1	7.50e-04	16	51	2	GO:0015923
GeneOntologyBiologicalProcess	lacrimal gland development	SOX9 MUC19 PAX6	7.91e-07	8	51	3	GO:0032808
GeneOntologyBiologicalProcess	exocrine system development	SOX9 EGFR MUC19 PAX6	1.19e-05	57	51	4	GO:0035272
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.42e-05	125	51	5	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	2.81e-05	144	51	5	GO:0070646
GeneOntologyBiologicalProcess	astrocyte differentiation	SOX9 EGFR ROR2 PAX6	1.32e-04	105	51	4	GO:0048708
GeneOntologyBiologicalProcess	salivary gland development	EGFR MUC19 PAX6	1.64e-04	43	51	3	GO:0007431
GeneOntologyBiologicalProcess	negative regulation of lipoprotein lipase activity	SORT1 ANGPTL4	1.66e-04	8	51	2	GO:0051005
GeneOntologyBiologicalProcess	glial cell fate specification	SOX9 PAX6	2.13e-04	9	51	2	GO:0021780
Domain	HABP4_PAI-RBP1	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	5.30e-10	16	51	5	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	5.30e-10	16	51	5	IPR006861
Domain	USP_CS	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	9.78e-07	66	51	5	IPR018200
Domain	USP_1	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.31e-06	70	51	5	PS00972
Domain	UCH	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.41e-06	71	51	5	PF00443
Domain	USP_2	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.41e-06	71	51	5	PS00973
Domain	USP_3	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.51e-06	72	51	5	PS50235
Domain	USP_dom	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.51e-06	72	51	5	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.51e-06	72	51	5	IPR001394
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2A1 MGAM2	1.27e-05	17	51	3	IPR011013
Domain	-	MAN2A2 MAN2A1	7.27e-05	5	51	2	1.20.1270.50
Domain	-	MAN2A2 MAN2A1	7.27e-05	5	51	2	3.20.110.10
Domain	Glyco_hydro_38_C	MAN2A2 MAN2A1	7.27e-05	5	51	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	7.27e-05	5	51	2	SM00872
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	7.27e-05	5	51	2	PF09261
Domain	Glyco_hydro_38_N	MAN2A2 MAN2A1	7.27e-05	5	51	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2A1	7.27e-05	5	51	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2A1	7.27e-05	5	51	2	IPR015341
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2A1	7.27e-05	5	51	2	IPR028995
Domain	Glyco_hydro_38C	MAN2A2 MAN2A1	7.27e-05	5	51	2	PF07748
Domain	Glyco_hydro_38	MAN2A2 MAN2A1	7.27e-05	5	51	2	PF01074
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2A1	1.52e-04	7	51	2	IPR011330
Domain	Homeodomain-like	TRERF1 PKNOX2 ZFHX4 GBX1 PAX6 MIDEAS	2.77e-04	332	51	6	IPR009057
Domain	Hud_Sxl_RNA	RBMS3 RBMS1	3.24e-04	10	51	2	IPR002343
Domain	Integrin_alpha	ITGAD ITGAX	3.96e-04	11	51	2	PF00357
Domain	ELM2	TRERF1 MIDEAS	5.59e-04	13	51	2	PF01448
Domain	ELM2	TRERF1 MIDEAS	5.59e-04	13	51	2	PS51156
Domain	ELM2_dom	TRERF1 MIDEAS	5.59e-04	13	51	2	IPR000949
Domain	ELM2	TRERF1 MIDEAS	5.59e-04	13	51	2	SM01189
Domain	-	MAN2A2 MAN2A1	6.51e-04	14	51	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2A2 MAN2A1	7.50e-04	15	51	2	IPR013780
Domain	Integrin_alpha_C_CS	ITGAD ITGAX	8.56e-04	16	51	2	IPR018184
Domain	Integrin_alpha-2	ITGAD ITGAX	1.09e-03	18	51	2	IPR013649
Domain	Integrin_alpha2	ITGAD ITGAX	1.09e-03	18	51	2	PF08441
Domain	Integrin_alpha	ITGAD ITGAX	1.09e-03	18	51	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGAD ITGAX	1.09e-03	18	51	2	PS00242
Domain	Int_alpha_beta-p	ITGAD ITGAX	1.21e-03	19	51	2	IPR013519
Domain	Int_alpha	ITGAD ITGAX	1.21e-03	19	51	2	SM00191
Domain	FG_GAP	ITGAD ITGAX	1.63e-03	22	51	2	PS51470
Domain	FG-GAP	ITGAD ITGAX	1.94e-03	24	51	2	PF01839
Domain	FG-GAP	ITGAD ITGAX	1.94e-03	24	51	2	IPR013517
Domain	Integrin_dom	ITGAD ITGAX	2.11e-03	25	51	2	IPR032695
Domain	SANT_dom	TRERF1 MIDEAS	2.28e-03	26	51	2	IPR017884
Domain	SANT	TRERF1 MIDEAS	2.64e-03	28	51	2	PS51293
Domain	Homeobox	PKNOX2 ZFHX4 GBX1 PAX6	3.78e-03	234	51	4	PF00046
Domain	HOMEOBOX_1	PKNOX2 ZFHX4 GBX1 PAX6	3.90e-03	236	51	4	PS00027
Domain	HOX	PKNOX2 ZFHX4 GBX1 PAX6	3.96e-03	237	51	4	SM00389
Domain	HOMEOBOX_2	PKNOX2 ZFHX4 GBX1 PAX6	4.08e-03	239	51	4	PS50071
Domain	Homeobox_dom	PKNOX2 ZFHX4 GBX1 PAX6	4.08e-03	239	51	4	IPR001356
Domain	Myb_DNA-binding	TRERF1 MIDEAS	4.11e-03	35	51	2	PF00249
Domain	MYB_LIKE	TRERF1 MIDEAS	4.83e-03	38	51	2	PS50090
Domain	AAA+_ATPase	MCM7 ABCD1 DNAH6	7.13e-03	144	51	3	IPR003593
Domain	AAA	MCM7 ABCD1 DNAH6	7.13e-03	144	51	3	SM00382
Domain	-	PKNOX2 ZFHX4 GBX1 PAX6	7.38e-03	283	51	4	1.10.10.60
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L12 USP17L20 USP17L5	8.42e-06	45	41	4	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L20 HGS USP17L24 USP17L5	3.94e-05	221	41	6	M27578
Pathway	BIOCARTA_EEA1_PATHWAY	EGFR HGS	1.23e-04	6	41	2	MM1577
Pathway	BIOCARTA_EEA1_PATHWAY	EGFR HGS	1.72e-04	7	41	2	M22064
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L20 HGS USP17L24 USP17L5	2.08e-04	299	41	6	M27574
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L20 HGS USP17L5	2.19e-04	191	41	5	MM15289
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	FADS2 ABCD1	2.29e-04	8	41	2	MM14822
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	FADS2 ABCD1	2.29e-04	8	41	2	M27115
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	FOXO1 PAX6 MAML3	2.42e-04	42	41	3	M17541
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FOXO1 USP17L21 USP17L12 EGFR USP17L20 USP17L5	2.90e-04	318	41	6	MM15278
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	MAN2A2 MAN2A1	3.66e-04	10	41	2	M27955
Pathway	WP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION	SOX9 SLC6A9 PCLO PAX6	5.69e-04	132	41	4	M48110
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	FADS2 ABCD1	6.31e-04	13	41	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	FADS2 ABCD1	6.31e-04	13	41	2	M27114
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	MAN2A2 MAN2A1	6.31e-04	13	41	2	MM15701
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L20 HGS USP17L5	9.26e-04	262	41	5	MM15286
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS	MAN2A2 MAN2A1	9.65e-04	16	41	2	M47632
Pathway	WP_EGFEGFR_SIGNALING	FOXO1 EGFR ATXN2 HGS	1.22e-03	162	41	4	M39334
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.41e-09	33	52	5	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	20403174
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	14699124
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	11941478
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	20388806
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	20368735
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.65e-09	34	52	5	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.92e-09	35	52	5	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.92e-09	35	52	5	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	2.23e-09	36	52	5	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	2.58e-09	37	52	5	20228808
Pubmed	Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.	SOX9 ANGPTL4 PAX6	1.26e-08	4	52	3	29986868
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L12 USP17L20 USP17L5	2.61e-08	21	52	4	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L12 USP17L20 USP17L5	2.61e-08	21	52	4	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L12 USP17L20 USP17L5	2.61e-08	21	52	4	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L12 USP17L20 USP17L5	2.61e-08	21	52	4	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L12 USP17L20 USP17L5	2.61e-08	21	52	4	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L12 USP17L20 USP17L5	2.61e-08	21	52	4	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L12 USP17L20 USP17L5	3.19e-08	22	52	4	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L12 USP17L20 USP17L5	4.62e-08	24	52	4	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L12 USP17L20 USP17L5	5.49e-08	25	52	4	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L12 USP17L20 USP17L5	6.48e-08	26	52	4	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L12 USP17L20 USP17L5	1.03e-07	29	52	4	32527007
Pubmed	Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.	SOX9 SLC6A9 PAX6	6.87e-07	12	52	3	21743471
Pubmed	Interaction network of human early embryonic transcription factors.	SORT1 TRERF1 ZFHX4 ZMYM2 ARID1A MIDEAS YTHDF3	9.10e-07	351	52	7	38297188
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L12 USP17L20 USP17L5	9.72e-07	50	52	4	31806660
Pubmed	Human transcription factor protein interaction networks.	TRERF1 SOX9 ZFHX4 ATXN2 RBMS1 HGS ZMYM2 PAX6 ARID1A MIDEAS SMAP2 YTHDF3	9.92e-07	1429	52	12	35140242
Pubmed	A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.	SOX9 EGFR PAX6	1.74e-06	16	52	3	38713624
Pubmed	Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.	FOXO1 SOX9 PAX6	2.11e-06	17	52	3	36529318
Pubmed	Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma.	EGFR ANGPTL4	2.19e-06	2	52	2	23617883
Pubmed	Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.	ITGAD ITGAX	2.19e-06	2	52	2	9598326
Pubmed	Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma.	EGFR PCLO	2.19e-06	2	52	2	28263981
Pubmed	The UIM domain of Hrs couples receptor sorting to vesicle formation.	EGFR HGS	2.19e-06	2	52	2	12953068
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	2.19e-06	2	52	2	8524845
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	2.19e-06	2	52	2	16754854
Pubmed	Phosphorylation of Hrs downstream of the epidermal growth factor receptor.	EGFR HGS	2.19e-06	2	52	2	12180964
Pubmed	N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.	MAN2A2 MAN2A1	2.19e-06	2	52	2	17113875
Pubmed	Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.	MAN2A2 MAN2A1	2.19e-06	2	52	2	11778047
Pubmed	Sortilin limits EGFR signaling by promoting its internalization in lung cancer.	SORT1 EGFR	2.19e-06	2	52	2	29084952
Pubmed	Pten Regulates Retinal Amacrine Cell Number by Modulating Akt, Tgfβ, and Erk Signaling.	SOX9 SLC6A9 PAX6	2.53e-06	18	52	3	27605619
Pubmed	Lim1 is essential for the correct laminar positioning of retinal horizontal cells.	SOX9 SLC6A9 PAX6	4.76e-06	22	52	3	18094249
Pubmed	Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.	SOX9 SLC6A9 PAX6	5.47e-06	23	52	3	25966682
Pubmed	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.	SOX9 EGFR	6.57e-06	3	52	2	25623042
Pubmed	CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.	EGFR HGS	6.57e-06	3	52	2	21635887
Pubmed	Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer.	EGFR BMP2K	6.57e-06	3	52	2	32792513
Pubmed	Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.	SORT1 EGFR	6.57e-06	3	52	2	25037567
Pubmed	Glucose-Induced β-Cell Dysfunction In Vivo: Evidence for a Causal Role of C-jun N-terminal Kinase Pathway.	ANGPTL4 PAX6	6.57e-06	3	52	2	30215691
Pubmed	EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.	SOX9 EGFR	6.57e-06	3	52	2	26455392
Pubmed	Linkage of open eyelids with linkage group VII of the mouse.	EGFR HGS	6.57e-06	3	52	2	5690495
Pubmed	Lipid availability determines fate of skeletal progenitor cells via SOX9.	FOXO1 SOX9	6.57e-06	3	52	2	32103177
Pubmed	Brief report: requirement of TACE/ADAM17 for hair follicle bulge niche establishment.	SOX9 EGFR	6.57e-06	3	52	2	22696231
Pubmed	A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor.	EGFR HGS	6.57e-06	3	52	2	15212941
Pubmed	FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.	FOXO1 SOX9	6.57e-06	3	52	2	31601652
Pubmed	A critical role for Sox9 in notch-induced astrogliogenesis and stem cell maintenance.	SOX9 PAX6	6.57e-06	3	52	2	23307615
Pubmed	m6 A reader YTHDF3 triggers the progression of hepatocellular carcinoma through the YTHDF3/m6 A-EGFR/STAT3 axis and EMT.	EGFR YTHDF3	6.57e-06	3	52	2	37449789
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	SORT1 FADS2 PANK1	8.00e-06	26	52	3	19060910
Pubmed	Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain.	SOX9 EGFR PAX6	8.99e-06	27	52	3	36915679
Pubmed	Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.	SOX9 SLC6A9 PAX6	8.99e-06	27	52	3	22323600
Pubmed	Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.	FOXO1 SOX9 ZMYM2 PAX6	1.08e-05	91	52	4	21194568
Pubmed	Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	SOX9 SLC6A9 PAX6	1.24e-05	30	52	3	30127719
Pubmed	Arid1a is essential for intestinal stem cells through Sox9 regulation.	SOX9 ARID1A	1.31e-05	4	52	2	30635419
Pubmed	Spatial regulation of EGFR signaling by Sprouty2.	EGFR HGS	1.31e-05	4	52	2	17320394
Pubmed	Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.	FOXO1 EGFR	1.31e-05	4	52	2	22653055
Pubmed	Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties.	EGFR HGS	1.31e-05	4	52	2	15828871
Pubmed	The DNA replication licensing factor miniature chromosome maintenance 7 is essential for RNA splicing of epidermal growth factor receptor, c-Met, and platelet-derived growth factor receptor.	EGFR MCM7	1.31e-05	4	52	2	25425645
Pubmed	Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation.	EGFR HGS	1.31e-05	4	52	2	17714434
Pubmed	Single-cell, whole-embryo phenotyping of mammalian developmental disorders.	SOX9 PAX6	1.31e-05	4	52	2	37968388
Pubmed	UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation.	EGFR HGS	1.31e-05	4	52	2	24344129
Pubmed	Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH.	EGFR HGS	1.31e-05	4	52	2	22800866
Pubmed	TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4.	FOXO1 ANGPTL4	1.31e-05	4	52	2	28215713
Pubmed	Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms.	SOX9 SLC6A9 PAX6	1.38e-05	31	52	3	38089586
Pubmed	Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.	SOX9 SLC6A9 PAX6	1.67e-05	33	52	3	25179941
Pubmed	Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells.	SOX9 PAX6 YTHDF3	1.99e-05	35	52	3	37269288
Pubmed	Endosomal type Iγ PIP 5-kinase controls EGF receptor lysosomal sorting.	EGFR HGS	2.19e-05	5	52	2	23602387
Pubmed	CD11a regulates hematopoietic stem and progenitor cells.	ITGAD ITGAX	2.19e-05	5	52	2	37781399
Pubmed	Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.	SOX9 EGFR	2.19e-05	5	52	2	25902485
Pubmed	Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes.	ITGAD ITGAX	2.19e-05	5	52	2	15210787
Pubmed	Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex.	EGFR HGS	2.19e-05	5	52	2	20736164
Pubmed	Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.	EGFR HGS	2.19e-05	5	52	2	11687594
Pubmed	Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.	EGFR HGS	2.19e-05	5	52	2	18508924
Pubmed	Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.	FOXO1 EGFR	2.19e-05	5	52	2	18844239
Pubmed	Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively.	EGFR HGS	2.19e-05	5	52	2	23153581
Pubmed	CD11c regulates hematopoietic stem and progenitor cells under stress.	ITGAD ITGAX	2.19e-05	5	52	2	33351105
Pubmed	A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.	SOX9 PAX6 ARID1A	2.56e-05	38	52	3	32541003
Pubmed	Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	SOX9 SLC6A9 PAX6	2.77e-05	39	52	3	29922981
Pubmed	Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.	FOXO1 SOX9 PAX6	2.77e-05	39	52	3	28576773
Pubmed	The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.	SOX9 MCM7 PAX6	3.00e-05	40	52	3	26657772
Pubmed	ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.	SOX9 ARID1A	3.28e-05	6	52	2	29604291
Pubmed	H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline.	FOXO1 SOX9	3.28e-05	6	52	2	32679061
Pubmed	LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.	EGFR HGS	3.28e-05	6	52	2	25588945
Pubmed	Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.	SOX9 ROR2	3.28e-05	6	52	2	21316585
Pubmed	Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.	EGFR HGS	3.28e-05	6	52	2	23477725
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	TRERF1 ZMYM2 MIDEAS	4.28e-05	45	52	3	21258344
Pubmed	SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.	EGFR HGS	4.58e-05	7	52	2	19158374
Interaction	SMAP2 interactions	EGFR BMP2K ATXN2 RBMS1 ROR2 HGS SMAP2 YTHDF3	2.33e-08	189	51	8	int:SMAP2
Interaction	DUXB interactions	ZFHX4 ZMYM2 MIDEAS YTHDF3	1.08e-07	18	51	4	int:DUXB
Interaction	CRX interactions	SORT1 TRERF1 ZFHX4 ROR2 HGS ARID1A MIDEAS SMAP2	2.27e-07	254	51	8	int:CRX
Interaction	ALG13 interactions	EGFR ATXN2 RBMS1 ROR2 ARID1A SMAP2 YTHDF3	3.75e-07	183	51	7	int:ALG13
Interaction	DAZL interactions	EGFR ATXN2 RBMS3 RBMS1 SMAP2 YTHDF3	1.72e-06	145	51	6	int:DAZL
Interaction	LARP4 interactions	EGFR ATXN2 RBMS1 PAX6 SMAP2 YTHDF3	1.45e-05	210	51	6	int:LARP4
Interaction	YTHDF3 interactions	FOXO1 ATXN2 HECW2 RBMS1 SMAP2 YTHDF3	3.54e-05	246	51	6	int:YTHDF3
Interaction	PAX6 interactions	SOX9 ZFHX4 HGS ZMYM2 PAX6 ARID1A MIDEAS	3.58e-05	366	51	7	int:PAX6
Interaction	LSM14A interactions	SORT1 EGFR ATXN2 HECW2 RBMS1 YTHDF3	4.82e-05	260	51	6	int:LSM14A
Interaction	LSM12 interactions	EGFR ATXN2 RBMS1 SMAP2 YTHDF3	5.83e-05	164	51	5	int:LSM12
Interaction	R3HDM1 interactions	ATXN2 RBMS1 SMAP2 YTHDF3	6.04e-05	84	51	4	int:R3HDM1
Interaction	GGA2 interactions	SORT1 EGFR HGS SMAP2	6.04e-05	84	51	4	int:GGA2
Interaction	CHMP6 interactions	UFSP2 EGFR ARID1A	7.90e-05	33	51	3	int:CHMP6
Interaction	MORC2 interactions	SORT1 EGFR HECW2 PAX6	8.26e-05	91	51	4	int:MORC2
Interaction	DPF1 interactions	SOX9 EGFR PAX6 ARID1A	9.77e-05	95	51	4	int:DPF1
Interaction	UBAP2L interactions	FOXO1 EGFR ATXN2 RBMS1 SMAP2 YTHDF3	1.02e-04	298	51	6	int:UBAP2L
Interaction	SOX9 interactions	SOX9 PAX6 ARID1A MIDEAS	1.06e-04	97	51	4	int:SOX9
Interaction	YTHDF1 interactions	EGFR ATXN2 RBMS3 RBMS1 SMAP2 YTHDF3	1.10e-04	302	51	6	int:YTHDF1
Interaction	HNF1B interactions	SOX9 ZFHX4 PAX6 ARID1A MIDEAS	1.17e-04	190	51	5	int:HNF1B
Interaction	SMG7 interactions	EGFR ATXN2 RBMS1 ARID1A SMAP2 YTHDF3	1.48e-04	319	51	6	int:SMG7
Interaction	MIDEAS interactions	TRERF1 SOX9 PAX6 MIDEAS	1.61e-04	108	51	4	int:MIDEAS
Interaction	RBM47 interactions	ATXN2 RBMS1 FADS2 SMAP2 YTHDF3	1.63e-04	204	51	5	int:RBM47
Interaction	BEND3 interactions	EGFR UBTFL1 ZMYM2 PAX6	1.78e-04	111	51	4	int:BEND3
Interaction	ZC3H7A interactions	ATXN2 RBMS1 MCM7 SMAP2 YTHDF3	2.08e-04	215	51	5	int:ZC3H7A
Interaction	GPKOW interactions	TRERF1 EGFR ATXN2 AK7	2.26e-04	118	51	4	int:GPKOW
Cytoband	4p16.1	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	3.24e-08	79	52	5	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	5.46e-06	222	52	5	chr4p16
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2A1	3.63e-05	5	35	2	1194
GeneFamily	CD molecules\|Integrin alpha subunits	ITGAD ITGAX	5.46e-04	18	35	2	1160
GeneFamily	Ataxins\|Trinucleotide repeat containing	ATXN2 MAML3	1.06e-03	25	35	2	775
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	HECW2 PCLO	2.20e-03	36	35	2	823
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	TRERF1 MIDEAS	4.72e-03	53	35	2	532
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L12 USP17L20 ANGPTL4 USP17L5	1.35e-05	160	50	5	MM1155
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L12 USP17L20 USP17L5	2.22e-05	86	50	4	MM1312
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_DN	SLC7A3 RBMS1 UBTFL1 ARID1A YTHDF3	3.85e-05	199	50	5	M9744
Coexpression	GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_DN	MAN2A2 BMP2K HGS ABCD1 MIDEAS	3.94e-05	200	50	5	M9735
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L12 USP17L20 USP17L5	6.25e-05	112	50	4	MM1095
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L21 UFSP2 USP17L12 RBMS3 USP17L20 RBMS1 ANGPTL4 FADS2 USP17L5 ABCD1	7.41e-05	1198	50	10	MM1062
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PKNOX2 SOX9 ZFHX4 EGFR RBMS3 ROR2	7.30e-08	199	48	6	6200618e029063486719479c41eaf31798bd13cf
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR RBMS3 ROR2	1.33e-06	177	48	5	b75f519d72611b293d9684f7dcfb1b70fbf54a90
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 EGFR RBMS3 PAX6 MAML3	1.37e-06	178	48	5	08b4a497aca0aeabf4f6a8a55c05b56417b69e78
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ERICH3 ZFHX4 RBMS3 C3orf70 MAML3	1.40e-06	179	48	5	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR RBMS3 ROR2	1.61e-06	184	48	5	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR RBMS3 ROR2	1.61e-06	184	48	5	ae0a77e3e520a246b17776bb19503519636b02ee
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR RBMS3 ROR2	1.70e-06	186	48	5	77592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRERF1 ZFHX4 RBMS3 UBTFL1 ROR2	1.74e-06	187	48	5	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 EGFR RBMS3 PAX6 MAML3	1.79e-06	188	48	5	ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR RBMS3 ROR2	1.79e-06	188	48	5	4544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR RBMS3 ROR2	1.88e-06	190	48	5	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	facs-GAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 MAN2A1 RBMS3 ANGPTL4 FADS2	1.93e-06	191	48	5	1f5d1e8c313a8dc83c06d2ee45f369b0ec507fbf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 ZFHX4 RBMS3 ROR2	1.98e-06	192	48	5	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 ZFHX4 RBMS3 ROR2	1.98e-06	192	48	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A3 EGFR RBMS3 ROR2 MAML3	2.03e-06	193	48	5	294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FOXO1 PKNOX2 RBMS3 ROR2 ANGPTL4	2.03e-06	193	48	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A3 EGFR RBMS3 ROR2 MAML3	2.03e-06	193	48	5	3d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SOX9 ZFHX4 EGFR RBMS3 ANGPTL4	2.30e-06	198	48	5	a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SOX9 ZFHX4 EGFR RBMS3 ANGPTL4	2.30e-06	198	48	5	8b68fc887e5ad0a59ea4d93dfd1edda67030f142
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SOX9 ZFHX4 EGFR RBMS3 ANGPTL4	2.30e-06	198	48	5	4739b2e4ab141c66772e61686b45614a1839483e
ToppCell	stromal_cell\|World / Lineage and Cell class	SOX9 ZFHX4 EGFR RBMS3 ANGPTL4	2.36e-06	199	48	5	507a82d0529b5b1fa5aebcfe43db53f0b6e3f8f0
ToppCell	stromal_cell-stromal_cell\|World / Lineage and Cell class	SOX9 ZFHX4 EGFR RBMS3 ANGPTL4	2.36e-06	199	48	5	74262363a34da3a1eb55ab375fd61ddd7bb39b23
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXO1 EGFR RBMS3 PAX6 MAML3	2.42e-06	200	48	5	c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXO1 EGFR RBMS3 PAX6 MAML3	2.42e-06	200	48	5	ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXO1 ZFHX4 EGFR RBMS3 MAML3	2.42e-06	200	48	5	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXO1 EGFR RBMS3 PAX6 MAML3	2.42e-06	200	48	5	8a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SOX9 EGFR FADS2 PAX6	1.32e-05	134	48	4	a632d78890fcc20db81d2cf6b299470706d2e182
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SOX9 EGFR FADS2 PAX6	1.32e-05	134	48	4	8be2db71d9d29f9a57a64efdc89cf8c3e32b363b
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 ITGAD ITGAX MAML3	2.53e-05	158	48	4	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 RBMS3 RBMS1 MAML3	2.59e-05	159	48	4	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 ITGAD ITGAX MAML3	2.79e-05	162	48	4	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZFHX4 EGFR PCLO PAX6	3.06e-05	166	48	4	9fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	EGFR RBMS3 PCLO PANK1	3.29e-05	169	48	4	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	3.29e-05	169	48	4	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 RBMS3 RBMS1 MAML3	3.36e-05	170	48	4	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 RBMS3 RBMS1 MAML3	3.36e-05	170	48	4	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR BMP2K ITGAD ITGAX	3.44e-05	171	48	4	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR BMP2K ITGAD ITGAX	3.44e-05	171	48	4	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP2K ROR2 ITGAD SMAP2	3.68e-05	174	48	4	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	COVID-19-lung-MAST\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRERF1 BMP2K ITGAX MAML3	3.85e-05	176	48	4	473c45a381ca109207d66ed1635668b391ea0e1f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SLC7A3 EGFR ROR2	4.02e-05	178	48	4	f332c7a96844abecf05ca057480fbea9296688a2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 ZFHX4 RBMS3 ROR2	4.02e-05	178	48	4	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR BMP2K ITGAD ITGAX	4.20e-05	180	48	4	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR BMP2K ITGAD ITGAX	4.20e-05	180	48	4	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR BMP2K ITGAD ITGAX	4.20e-05	180	48	4	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR RBMS3 PAX6 MAML3	4.29e-05	181	48	4	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ERICH3 ZFHX4 C3orf70 MAML3	4.39e-05	182	48	4	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	droplet-Thymus-nan-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 RBMS3 ITGAX DNAH6	4.39e-05	182	48	4	f6717e97e87513384149800c9fd8dea821ab9393
ToppCell	droplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 RBMS3 ITGAX DNAH6	4.39e-05	182	48	4	c33b0d532822186a1e8e645500347972468718c0
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 EGFR RBMS3 ROR2	4.48e-05	183	48	4	f8b636391f752e379a5c5575fd898bdf0907a3b8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 MCM7 ITGAD ITGAX	4.48e-05	183	48	4	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	4.58e-05	184	48	4	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 EGFR RBMS3 MAML3	4.67e-05	185	48	4	487fa382232564f075960899d50afa0edae5d258
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SORT1 RBMS3 PCLO ITGAX	4.67e-05	185	48	4	b4af9ae4c358b48357cb135b740266e1652d886a
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PKNOX2 SOX9 RBMS3 ROR2	4.77e-05	186	48	4	7def03dd856b765bd3f493288641981c4f7fd26e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	2b1b2c3792d6c9ab69675ce88842bb589414b530
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	4.87e-05	187	48	4	93c78fc7f126132eb84feb47be2c4e8c568b9e91
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR RBMS3 PAX6 MAML3	4.87e-05	187	48	4	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 EGFR RBMS3 MAML3	4.87e-05	187	48	4	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.08e-05	189	48	4	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.08e-05	189	48	4	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A3 EGFR RBMS3 ROR2	5.18e-05	190	48	4	3b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	5.18e-05	190	48	4	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	5.18e-05	190	48	4	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 EGFR RBMS3 ROR2	5.18e-05	190	48	4	59720dfe9de1b980807644536c919d2a02ba69dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 RBMS3 ROR2 C3orf70	5.18e-05	190	48	4	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A3 EGFR RBMS3 ROR2	5.18e-05	190	48	4	dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 ZFHX4 ANGPTL4 PAX6	5.18e-05	190	48	4	1c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PKNOX2 RBMS3 RBMS1 ROR2	5.29e-05	191	48	4	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	SORT1 MAN2A1 ANGPTL4 ITGAX	5.29e-05	191	48	4	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SORT1 RBMS3 ANGPTL4 FADS2	5.29e-05	191	48	4	80484d39f34703a33b9bac09826b7a526e883cab
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.29e-05	191	48	4	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SORT1 RBMS3 ANGPTL4 FADS2	5.29e-05	191	48	4	5c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.29e-05	191	48	4	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A3 EGFR RBMS3 ROR2	5.40e-05	192	48	4	f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 EGFR FADS2 PAX6	5.40e-05	192	48	4	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SOX9 ZFHX4 ANGPTL4	5.40e-05	192	48	4	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	EGFR RBMS1 ANGPTL4 ITGAX	5.40e-05	192	48	4	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC7A3 EGFR RBMS3 ROR2	5.40e-05	192	48	4	690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SOX9 ZFHX4 ANGPTL4	5.51e-05	193	48	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 SOX9 ZFHX4 ANGPTL4	5.51e-05	193	48	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RBMS3 HECW2 RBMS1 C3orf70	5.51e-05	193	48	4	456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.62e-05	194	48	4	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FOXO1 PKNOX2 RBMS3 ROR2	5.62e-05	194	48	4	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR RBMS3 ROR2 MAML3	5.62e-05	194	48	4	6ac759828c41ffa974ee82842162caa959351dd1
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TRERF1 ZFHX4 EGFR ROR2	5.62e-05	194	48	4	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.62e-05	194	48	4	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 MCM7 DEPDC1 ITGAX	5.62e-05	194	48	4	effd38e51062b225ecabc7e1c50154e65495d559
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR RBMS3 ROR2 MAML3	5.62e-05	194	48	4	5d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.62e-05	194	48	4	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 PKNOX2 RBMS3 ROR2	5.62e-05	194	48	4	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PKNOX2 ZFHX4 RBMS3 ROR2	5.73e-05	195	48	4	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SORT1 MCM7 DEPDC1 ITGAX	5.73e-05	195	48	4	c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 ZFHX4 RBMS3 FADS2	5.73e-05	195	48	4	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TRERF1 ZFHX4 EGFR ROR2	5.73e-05	195	48	4	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.48e-08	46	50	5	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L12 USP17L20 USP17L24 USP17L5	1.18e-07	69	50	5	DOID:1682 (implicated_via_orthology)
Disease	triglycerides in large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.19e-04	56	50	3	EFO_0022178
Disease	triglycerides in very large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.19e-04	56	50	3	EFO_0022325
Disease	oleoyl-linoleoyl-glycerol (18:1/18:2) [2] measurement	ANGPTL4 FADS2	1.26e-04	10	50	2	EFO_0800333
Disease	triglycerides in VLDL measurement	ANGPTL4 FADS2 ARID1A	1.39e-04	59	50	3	EFO_0022326
Disease	triglycerides to total lipids in large HDL percentage	ANGPTL4 FADS2 ARID1A	1.46e-04	60	50	3	EFO_0022330
Disease	triglycerides in small VLDL measurement	ANGPTL4 FADS2 ARID1A	1.54e-04	61	50	3	EFO_0022145
Disease	free cholesterol in very large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.54e-04	61	50	3	EFO_0022274
Disease	wellbeing measurement	EGFR ATXN2 RBMS3 PCLO MUC19 PAX6 MAML3	1.57e-04	692	50	7	EFO_0007869
Disease	phospholipids in large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.61e-04	62	50	3	EFO_0022169
Disease	triglycerides in medium LDL measurement	ANGPTL4 FADS2 ARID1A	1.61e-04	62	50	3	EFO_0022322
Disease	total lipids in very large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.61e-04	62	50	3	EFO_0022313
Disease	phospholipids in very large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.61e-04	62	50	3	EFO_0022299
Disease	platelet crit	FOXO1 EGFR ATXN2 FADS2 ITGAD ARID1A ITGAX PANK1	1.84e-04	952	50	8	EFO_0007985
Disease	triglycerides in small LDL measurement	ANGPTL4 FADS2 ARID1A	1.86e-04	65	50	3	EFO_0022323
Disease	cholesterol in very large VLDL measurement	ANGPTL4 FADS2 ARID1A	1.86e-04	65	50	3	EFO_0022230
Disease	total lipids in large VLDL	ANGPTL4 FADS2 ARID1A	2.03e-04	67	50	3	EFO_0022175
Disease	triglycerides to phosphoglycerides ratio	ANGPTL4 FADS2 ARID1A	2.12e-04	68	50	3	EFO_0022327
Disease	free cholesterol in large VLDL measurement	ANGPTL4 FADS2 ARID1A	2.12e-04	68	50	3	EFO_0022265
Disease	triglycerides to total lipids in small HDL percentage	ANGPTL4 FADS2 ARID1A	2.51e-04	72	50	3	EFO_0022336
Disease	phospholipids in large HDL measurement	ANGPTL4 FADS2 ARID1A	2.62e-04	73	50	3	EFO_0022190
Disease	alcohol use disorder (implicated_via_orthology)	EGFR ANGPTL4 FADS2 ARID1A	3.36e-04	195	50	4	DOID:1574 (implicated_via_orthology)
Disease	reticulocyte count	FOXO1 BMP2K ATXN2 RBMS1 ANGPTL4 ITGAD MIDEAS ITGAX	3.45e-04	1045	50	8	EFO_0007986
Disease	level of Sphingomyelin (d38:2) in blood serum	ANGPTL4 FADS2	4.72e-04	19	50	2	OBA_2045179
Disease	mean corpuscular hemoglobin concentration	FOXO1 SLC6A9 EGFR BMP2K ATXN2 HECW2 FADS2 MIDEAS	5.00e-04	1105	50	8	EFO_0004528
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	ATXN2 ANGPTL4 FADS2 ARID1A	5.66e-04	224	50	4	EFO_0004574, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	ATXN2 ANGPTL4 FADS2 ARID1A	5.76e-04	225	50	4	EFO_0008317, EFO_0010351
Disease	triglyceride measurement, alcohol drinking	ANGPTL4 FADS2 ARID1A	6.40e-04	99	50	3	EFO_0004329, EFO_0004530
Disease	triglyceride measurement, alcohol consumption measurement	ANGPTL4 FADS2 ARID1A	6.79e-04	101	50	3	EFO_0004530, EFO_0007878
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	ATXN2 ANGPTL4 ARID1A	7.19e-04	103	50	3	EFO_0008595, EFO_0020944
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	ATXN2 ANGPTL4 FADS2	7.39e-04	104	50	3	EFO_0008591, EFO_0008595
Disease	basophil count, eosinophil count	TRERF1 FOXO1 ATXN2 FADS2	7.44e-04	241	50	4	EFO_0004842, EFO_0005090
Disease	Intrahepatic Cholangiocarcinoma	EGFR ARID1A	7.58e-04	24	50	2	C0345905
Disease	gamma-linolenic acid measurement	FADS2 MAML3	7.58e-04	24	50	2	EFO_0007762
Disease	Extrahepatic Cholangiocarcinoma	EGFR ARID1A	7.58e-04	24	50	2	C3805278
Disease	lipoprotein measurement	ANGPTL4 FADS2 ARID1A	7.60e-04	105	50	3	EFO_0004732
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	ANGPTL4 ARID1A MIDEAS	8.03e-04	107	50	3	EFO_0004614, EFO_0004615
Disease	Cholangiocarcinoma	EGFR ARID1A	8.91e-04	26	50	2	C0206698
Disease	cholesteryl ester measurement	ATXN2 ANGPTL4 FADS2 ARID1A	9.45e-04	257	50	4	EFO_0010351
Disease	eye measurement	FOXO1 ATXN2	9.61e-04	27	50	2	EFO_0004731
Disease	triacylglycerol 54:7 measurement	FADS2 MAML3	1.03e-03	28	50	2	EFO_0010425
Disease	serum IgA measurement	ATXN2 FADS2	1.27e-03	31	50	2	EFO_0004912
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	ATXN2 ANGPTL4 FADS2	1.32e-03	127	50	3	EFO_0008595, EFO_0020947
Disease	esterified cholesterol measurement	ATXN2 ANGPTL4 FADS2	1.35e-03	128	50	3	EFO_0008589
Disease	cholesteryl ester 22:6 measurement	EGFR FADS2	1.35e-03	32	50	2	EFO_0010350
Disease	Squamous cell carcinoma of lung	EGFR BMP2K	1.35e-03	32	50	2	C0149782
Disease	monocyte percentage of leukocytes	TRERF1 FOXO1 ATXN2 RBMS1 FADS2 ARID1A	1.42e-03	731	50	6	EFO_0007989
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	ATXN2 ANGPTL4 FADS2 ARID1A	1.49e-03	291	50	4	EFO_0008317, EFO_0020946
Disease	very low density lipoprotein particle size measurement	ANGPTL4 FADS2 ARID1A	1.50e-03	133	50	3	EFO_0008594
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	ATXN2 ANGPTL4 FADS2	1.64e-03	137	50	3	EFO_0004611, EFO_0008591
Disease	hepatocellular carcinoma (is_marker_for)	FOXO1 EGFR MCM7 ARID1A	1.69e-03	301	50	4	DOID:684 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYQLPNINSYMMPIP	ERICH3	221	Q5RHP9
RYYPLQATTMLIQPM	ANGPTL4	386	Q9BY76
CKYMYQPMTPVEQLP	C3orf70	66	A6NLC5
PQPSASQYPTMMPQY	BMP2K	526	Q9NSY1
VVMSYLQNPQPMTPP	WDR83OS	91	Q9Y284
MPATSAMQGAYLPQY	RBMS1	356	P29558
QYMTAAAPMQGTYIP	RBMS3	366	Q6XE24
LYPPNMSPTFINMSQ	ITGAX	381	P20702
PQRMFYIPQRPYMSV	ABCD1	536	P33897
PYGSQTPQRYPMTMQ	ARID1A	421	O14497
GYMQRNPQMPQYSSP	ARID1A	751	O14497
MFFNPDPYLKMSIQP	HECW2	201	Q9P2P5
YSALPPMPSFTMANN	PAX6	326	P26367
PPLLIPMYFQYQIIM	FADS2	271	O95864
PLQANVYPMTTMAYI	MAN2A1	911	Q16706
KPNSPMMYPQAFNNQ	MAML3	536	Q96JK9
MMYPQAFNNQNPIVP	MAML3	541	Q96JK9
SNEMLNNPPYMPYLE	MGAM2	1391	Q2M2H8
PVYTQPVCFAPNMMY	ATXN2	956	Q99700
PQPSYQLPSQMMVIQ	PCLO	3946	Q9Y6V0
VPVMQLYVSMPPNQF	MUC19	931	Q7Z5P9
INPKQVIPQYIMYNM	DEPDC1	211	Q5TB30
TYQPIQSPTFMPLIM	MCM7	191	P33993
YPPNMSPTFINMSQE	ITGAD	381	Q13349
PLMLYNPTTYQMDVN	EGFR	266	P00533
QMYKLMEQYQVPTPP	DNAH6	756	Q9C0G6
YPMFMPYRPLVLPQA	GBX1	46	Q14549
YGQSSMSPLPQMPIQ	FOXO1	426	Q12778
LPLQANFYPMPVMAY	MAN2A2	916	P49641
PQMPLFENFYSMPQQ	MIDEAS	266	Q6PJG2
LTMMATQNVPPPPYQ	PKNOX2	11	Q96KN3
LTLMMPYYQLQPESP	SLC7A3	306	Q8WY07
PYCLDNPYPMLLVNM	PANK1	401	Q8TE04
NLYLLMPPTMNPIVY	OR52N1	281	Q8NH53
PLTQMMYSPQNSDYL	SORT1	216	Q99523
NFYPVQIPMQMAPQQ	ROR2	836	Q01974
FTYMNPAQRPMYTPI	SOX9	466	P48436
VMDLNPAPNQYQMPL	ODF3L1	151	Q8IXM7
TYLNPPNMETGMIYV	UFSP2	266	Q9NUQ7
DQPMPYLTTYGQMSN	YTHDF3	81	Q7Z739
PYMIFDPNNPLMTGQ	ZFHX4	2491	Q86UP3
PQYSQMYPGMRSQEL	UBTFL1	116	P0CB47
VPSGYQNYRQMSMPT	SPEM3	1121	A0A1B0GUW6
MAPAQMAYPTAYPSF	SMAP2	286	Q8WU79
YQPYNMQNLMTTLPS	HGS	706	O14964
QYPECLDMQPYMSQP	USP17L5	296	A8MUK1
QYPECLDMQPYMSQP	USP17L21	296	D6R901
YFQDIQMMLGFPPPL	SLC6A9	556	P48067
VYIPVPMHMYSQNIP	ZMYM2	891	Q9UBW7
QYPECLDMQPYMSQP	USP17L12	296	C9JPN9
QYPECLDMQPYMSQP	USP17L24	296	Q0WX57
QYPECLDMQPYMSQP	USP17L20	296	D6RJB6
MQIPQYYQPQPMMQH	TRERF1	321	Q96PN7
MPVPVIVNNFGMYYS	KCNC4	466	Q03721
QSIPLRNYLMTYVMP	AK7	676	Q96M32